Search

Your search keyword '"Scheel, Amy"' showing total 44 results
Start Over Author "Scheel, Amy"
44 results on '"Scheel, Amy"'

3. Refining Risk Stratification Among Children With Latent Rheumatic Heart Disease

Author

Beaton, Andrea, Okello, Emmy, Rwebembera, Joselyn, Grobler, Anneke, Engelman, Daniel, Alepere, Juliet, Carapetis, Jonathan, DeWyer, Alyssa, Lwabi, Peter, Mirabel, Mariana, Mocumbi, Ana Olga, Nakitto, Miriam, Ndagire, Emma, Nunes, Maria Carmo P., Omara, Isaac Otim, Sarnacki, Rachel, Scheel, Amy, Wilson, Nigel, Zühlke, Liesl, Karthikeyan, Ganesan, Sable, Craig A., and Steer, Andrew C.

Published
2023
Full Text
View/download PDF

5. Abstract 15349: Factors Associated With Progression of Latent Rheumatic Heart Disease

Author

Beaton, Andrea Z, Okello, Emmy, Rwebembera, Joselyn, Engelman, Daniel, Carapetis, Jonathan, DEWYER, ALYSSA, Fall, Ndate, Lwabi, Peter, Mirabel, Mariana, Mocumbi, Ana O, nakitto, miriam, Ndagire, Emma, Nunes, Maria D, Pulle, Jafesi, Omara, Isaac, Sarnacki, Rachel, Scheel, Amy, Wilson, Nigel, Zimmerman, Meghan, Zuhlke, Liesl, Karthikeyan, Ganesan, Sable, Craig A, Grobler, Anneke, and Steer, Andrew

Published
2022
Full Text
View/download PDF

7. Incidence of Sexually Transmitted Infections in Youth with HIV During Pre-COVID and COVID Era.

Author

Khan, Firdous, Loerinc, Leah B., Scheel, Amy, Gillespie, Scott E., and Camacho-Gonzalez, Andres F.

Subjects
PREVENTION of sexually transmitted diseases, EPIDEMIOLOGY of sexually transmitted diseases, SEXUALLY transmitted disease risk factors, RISK assessment, BACTERIAL vaginitis, HIV-positive persons, LYMPHOGRANULOMA venereum, RETROSPECTIVE studies, PAPILLOMAVIRUSES, DESCRIPTIVE statistics, REINFECTION, CHLAMYDIA infections, SYPHILIS, MEDICAL records, ACQUISITION of data, GONORRHEA, COMPARATIVE studies, TRICHOMONIASIS, HERPES simplex, HEPATITIS C, COVID-19 pandemic, CHANCROID
Abstract

Adolescents and young adults (AYAs) living with HIV have high rates of co-sexually transmitted infections (STIs). During the coronavirus disease (COVID) pandemic, STI prevention strategies, including access to testing/treatment facilities, availability of health care workers, and condom availability, may have decreased. This study aimed to determine if differences in STI incidence for first infection and reinfection existed between the pre-COVID and COVID eras in a cohort of AYAs living with HIV in Atlanta, GA. Retrospective chart review was conducted for all patients between ages 13 and 24 at the Grady Ponce Clinic. Two eras were identified: a pre-COVID era (January 1, 2009–December31, 2019) and a COVID era (January 1, 2020–June 30, 2021). STIs recorded included gonorrhea, chlamydia, human papillomavirus, syphilis, trichomonas, herpes simplex virus, lymphogranuloma venereum, hepatitis C, bacterial vaginosis, and chancroid. First and recurrent incidence rates for any STIs were reported. Our sample included 766 sexually active AYAs with HIV. A total of 721 patients were included in the pre-COVID era and 583 (80.9%) had at least one STI. A total of 337 patients were included in the COVID era, and 158 had at least one STI (46.9%). The overall first STI incidence rate increased from 42.47 to 58.67 per 100 person-years (PY) and the recurrent STI incidence rate increased from 121.50 to 169.85 per 100 PY from the pre-COVID to the COVID era (p < 0.001). Our study demonstrated significantly higher incidence rates of first and recurrent STIs in AYAs living with HIV in the COVID era. We urge continuation of existing STI prevention programs to avoid secondary clinical and economic adverse effects of increased infections. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Prevalence of group A β-hemolytic streptococcal throat carriage and prospective pilot surveillance of streptococcal sore throat in Ugandan school children

Author

DeWyer, Alyssa, Scheel, Amy, Webel, Allison R., Longenecker, Chris T., Kamarembo, Jennipher, Aliku, Twalib, Engel, Mark E., Bowen, Asha C., Bwanga, Freddie, Hovis, Ian, Chang, Aileen, Sarnacki, Rachel, Sable, Craig, Dale, James B., Carapetis, Jonathan, Rwebembera, Joselyn, Okello, Emmy, and Beaton, Andrea

Published
2020
Full Text
View/download PDF

13. Comparison of approaches to determine echocardiographic outcomes for children with latent rheumatic heart disease

Author

Rwebembera, Joselyn, primary, Beaton, Andrea, additional, Okello, Emmy, additional, Engelman, Daniel, additional, Fall, Ndate, additional, Mirabel, Mariana, additional, Nakitto, Miriam, additional, Pereira Nunes, Maria Carmo, additional, Pulle, Jafesi, additional, Sarnacki, Rachel, additional, Scheel, Amy, additional, Zuhlke, Liesl, additional, Grobler, Anneke, additional, Steer, Andrew Craig, additional, and Sable, Craig, additional

Published
2022
Full Text
View/download PDF

15. Standardization of Epidemiological Surveillance of Acute Rheumatic Fever

Author

Scheel, Amy, primary, Beaton, Andrea Z, additional, Katzenellenbogen, Judith, additional, Parks, Tom, additional, Miller, Kate M, additional, Cherian, Thomas, additional, Van Beneden, Chris A, additional, Cannon, Jeffrey W, additional, Moore, Hannah C, additional, Bowen, Asha C, additional, and Carapetis, Jonathan R, additional

Published
2022
Full Text
View/download PDF

16. Standardization of Epidemiological Surveillance of Acute Poststreptococcal Glomerulonephritis

Author

Miller, Kate M, primary, Van Beneden, Chris, additional, McDonald, Malcolm, additional, Hla, Thel K, additional, Wong, William, additional, Pedgrift, Helen, additional, Kaslow, David C, additional, Cherian, Thomas, additional, Carapetis, Jonathan R, additional, Scheel, Amy, additional, Seale, Anna, additional, Bowen, Asha C, additional, Moore, Hannah C, additional, Lamagni, Theresa, additional, and Rodriguez-Iturbe, Bernardo, additional

Published
2022
Full Text
View/download PDF

18. Rheumatic Heart Disease Treatment Cascade in Uganda

Author

Longenecker, Chris T., Morris, Stephen R., Aliku, Twalib O., Beaton, Andrea, Costa, Marco A., Kamya, Moses R., Kityo, Cissy, Lwabi, Peter, Mirembe, Grace, Nampijja, Dorah, Rwebembera, Joselyn, Sable, Craig, Salata, Robert A., Scheel, Amy, Simon, Daniel I., Ssinabulya, Isaac, and Okello, Emmy

Published
2017
Full Text
View/download PDF

19. Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Rwebembera, Joselyn, additional, Grobler, Anneke, additional, Engelman, Daniel, additional, Alepere, Juliet, additional, Canales, Lesley, additional, Carapetis, Jonathan, additional, DeWyer, Alyssa, additional, Lwabi, Peter, additional, Mirabel, Mariana, additional, Mocumbi, Ana O., additional, Murali, Meghna, additional, Nakitto, Miriam, additional, Ndagire, Emma, additional, Nunes, Maria C.P., additional, Omara, Isaac O., additional, Sarnacki, Rachel, additional, Scheel, Amy, additional, Wilson, Nigel, additional, Zimmerman, Meghan, additional, Zühlke, Liesl, additional, Karthikeyan, Ganesan, additional, Sable, Craig A., additional, and Steer, Andrew C., additional

Published
2022
Full Text
View/download PDF

20. Abstract 12503: A Randomized Controlled Trial of Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Author

Beaton, Andrea Z, primary, Okello, Emmy, additional, Rwebembera, Joselyn, additional, Grobler, Anneke, additional, Engelman, Daniel, additional, Carapetis, Jonathan, additional, Canales, Lesley, additional, DEWYER, ALYSSA, additional, Lwabi, Peter, additional, Mirabel, Mariana, additional, Mocumbi, Ana O, additional, Murali, Meghna, additional, nakitto, miriam, additional, Ndagire, Emma, additional, Nunes, Maria, additional, Omara, Isaac, additional, Sarnacki, Rachel, additional, Scheel, Amy, additional, Wilson, Nigel, additional, Zimmerman, Meghan, additional, Zuhlke, Liesl, additional, Karthikeyan, Ganesan, additional, Sable, Craig A, additional, and Steer, Andrew, additional

Published
2021
Full Text
View/download PDF

22. Establishment of a cardiac telehealth program to support cardiovascular diagnosis and care in a remote, resource-poor setting in Uganda

Author

DeWyer, Alyssa, primary, Scheel, Amy, additional, Kamarembo, Jenipher, additional, Akech, Rose, additional, Asiimwe, Allan, additional, Beaton, Andrea, additional, Bobson, Bua, additional, Canales, Lesley, additional, DeStigter, Kristen, additional, Kazi, Dhruv S., additional, Kwan, Gene F., additional, Longenecker, Chris T., additional, Lwabi, Peter, additional, Murali, Meghna, additional, Ndagire, Emma, additional, Namuyonga, Judith, additional, Sarnacki, Rachel, additional, Ssinabulya, Isaac, additional, Okello, Emmy, additional, Aliku, Twalib, additional, and Sable, Craig, additional

Published
2021
Full Text
View/download PDF

23. Standardization of Epidemiological Surveillance of Rheumatic Heart Disease.

Author

Scheel, Amy, Miller, Kate M, Beaton, Andrea, Katzenellenbogen, Judith, Parks, Tom, Cherian, Thomas, Beneden, Chris A Van, Cannon, Jeffrey W, Moore, Hannah C, Bowen, Asha C, Carapetis, Jonathan R, and Group, for the Strep A Vaccine Global Consortium (SAVAC) Burden of Disease Working

Subjects
*RHEUMATIC heart disease, *RHEUMATIC fever, *HEART valves, *STREPTOCOCCUS pyogenes, *YOUNG adults, *MIDDLE-income countries
Abstract

Rheumatic heart disease (RHD) is a long-term sequela of acute rheumatic fever (ARF), which classically begins after an untreated or undertreated infection caused by Streptococcus pyogenes (Strep A). RHD develops after the heart valves are permanently damaged due to ARF. RHD remains a leading cause of morbidity and mortality in young adults in resource-limited and low- and middle-income countries. This article presents case definitions for latent, suspected, and clinical RHD for persons with and without a history of ARF, and details case classifications, including differentiating between definite or borderline according to the 2012 World Heart Federation echocardiographic diagnostic criteria. This article also covers considerations specific to RHD surveillance methodology, including discussions on echocardiographic screening, where and how to conduct active or passive surveillance (eg, early childhood centers/schools, households, primary healthcare), participant eligibility, and the surveillance population. Additional considerations for RHD surveillance, including implications for secondary prophylaxis and follow-up, RHD registers, community engagement, and the negative impact of surveillance, are addressed. Finally, the core elements of case report forms for RHD, monitoring and audit requirements, quality control and assurance, and the ethics of conducting surveillance are discussed. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

24. The inter-rater reliability and individual reviewer performance of the 2012 world heart federation guidelines for the echocardiographic diagnosis of latent rheumatic heart disease

Author

Scheel, Amy, primary, Mirabel, Mariana, additional, Nunes, Maria Carmo Pereira, additional, Okello, Emmy, additional, Sarnacki, Rachel, additional, Steer, Andrew C., additional, Engelman, Daniel, additional, Zimmerman, Meghan, additional, Zühlke, Liesl, additional, Sable, Craig, additional, and Beaton, Andrea, additional

Published
2021
Full Text
View/download PDF

30. Determining the impact of Benzathine penicillin G prophylaxis in children with latent rheumatic heart disease (GOAL trial): Study protocol for a randomized controlled trial

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Engelman, Daniel, additional, Grobler, Anneke, additional, Scheel, Amy, additional, DeWyer, Alyssa, additional, Sarnacki, Rachel, additional, Omara, Isaac Otim, additional, Rwebembera, Joselyn, additional, Sable, Craig, additional, and Steer, Andrew, additional

Published
2019
Full Text
View/download PDF

31. Improving the accuracy of heart failure diagnosis in low-resource settings through task sharing and decentralization

Author

DeWyer, Alyssa, primary, Scheel, Amy, additional, Otim, Isaac Omara, additional, Longenecker, Christopher T., additional, Okello, Emmy, additional, Ssinabulya, Isaac, additional, Morris, Stephen, additional, Okwir, Mark, additional, Oyang, William, additional, Joyce, Erine, additional, Nabongo, Betty, additional, Sable, Craig, additional, Alencherry, Ben, additional, Tompsett, Alison, additional, Aliku, Twalib, additional, and Beaton, Andrea, additional

Published
2019
Full Text
View/download PDF

32. Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Scheel, Amy, additional, DeWyer, Alyssa, additional, Ssembatya, Renny, additional, Baaka, Olivia, additional, Namisanvu, Henrietor, additional, Njeri, Angela, additional, Matovu, Alphons, additional, Namagembe, Imelda, additional, Mccarter, Robert, additional, Carapetis, Jonathan, additional, DeStigter, Kristen, additional, and Sable, Craig, additional

Published
2018
Full Text
View/download PDF

34. Community study to uncover the full spectrum of rheumatic heart disease in Uganda

Author

Scheel, Amy, primary, Ssinabulya, Isaac, additional, Aliku, Twalib, additional, Bradley-Hewitt, Tyler, additional, Clauss, Alexa, additional, Clauss, Sarah, additional, Crawford, Lexi, additional, DeWyer, Alyssa, additional, Donofrio, Mary T, additional, Jacobs, Marni, additional, Klein, Jennifer, additional, Moore, Teresa E, additional, Okello, Emmy, additional, Scheel, Janet, additional, Shaw, Rebekah, additional, Sable, Craig, additional, Lwabi, Peter, additional, Watkins, David A, additional, and Beaton, Andrea, additional

Published
2018
Full Text
View/download PDF

37. Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting.

Author

Beaton, Andrea, Okello, Emmy, Scheel, Amy, DeWyer, Alyssa, Ssembatya, Renny, Baaka, Olivia, Namisanvu, Henrietor, Njeri, Angela, Matovu, Alphons, Namagembe, Imelda, Mccarter, Robert, Carapetis, Jonathan, Destigter, Kristen, and Sable, Craig

Subjects
NEONATAL mortality, HEART diseases, RHEUMATIC heart disease, FETAL diseases, HEART disease related mortality, PRENATAL care, LOW-income countries
Abstract

Background: The burden of pre-existing cardiovascular disease and the contribution to adverse pregnancy outcomes are not robustly quantified, particularly in low-income countries. We aimed to determine both the prevalence of maternal heart disease through active case finding and its attributable risk to adverse pregnancy outcomes.Methods: We conducted a 24-month prospective longitudinal investigation in three Ugandan health centres, using echocardiography for active case finding during antenatal care. Women with and without heart disease were followed to 6 weeks post partum to determine pregnancy outcomes. Prevalence of heart disease was calculated. Per cent attributable risk estimates were generated for maternal, fetal and neonatal mortality.Results: Screening echocardiography was performed in 3506 women. The prevalence of heart disease was 17 per 1000 women (95% CI 13 to 21); 15 per 1000 was rheumatic heart disease. Only 3.4% of women (2/58) had prior diagnosis. Cardiovascular complications occurred in 51% of women with heart disease, most commonly heart failure. Per cent attributable risk of heart disease on maternal mortality was 88.6% in the exposed population and 10.8% in the overall population. Population attributable risk of heart disease on fetal death was 1.1% and 6.0% for neonatal mortality CONCLUSIONS: Occult maternal heart disease may be responsible for a substantial proportion of adverse pregnancy outcomes in low-resource settings. Rheumatic heart disease is, by far, the most common condition, urging global prioritisation of this neglected cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

38. Community study to uncover the full spectrum of rheumatic heart disease in Uganda.

Author

Scheel, Amy, Ssinabulya, Isaac, Aliku, Twalib, Bradley-Hewitt, Tyler, Clauss, Alexa, Clauss, Sarah, Crawford, Lexi, DeWyer, Alyssa, Donofrio, Mary T., Jacobs, Marni, Klein, Jennifer, Moore, Teresa E., Okello, Emmy, Scheel, Janet, Shaw, Rebekah, Sable, Craig, Lwabi, Peter, Watkins, David A., and Beaton, Andrea

Subjects
RHEUMATIC heart disease, RHEUMATISM, RHEUMATIC fever, AORTIC valve insufficiency, MITRAL valve insufficiency
Published
2019
Full Text
View/download PDF

42. Abstract 14563: The Reliability of the World Heart Federation Guidelines for the Echocardiographic Diagnosis of Rheumatic Heart Disease

Author

Beaton, Andrea Z, Scheel, Amy, Zimmerman, Meghan, Sarnacki, Rachel, Mirabel, Mariana, Nunes, Maria Do Carmo P, Steer, Andrew, Okello, Emmy, Zuhlke, Liesl, and Sable, Craig A

Abstract

Background:In 2012, the World Heart Federation (WHF) published guidelines for the echocardiographic diagnosis of rheumatic heart disease (RHD). This study assesses the reliability of the 2012 WHF criteria in the context of a randomized clinical trial (ClinicalTrials.gov: NCT03346525).Methods:Four cardiologists with experience in the WHF criteria were selected to review echocardiograms and to participate in a blinded adjudication panel. Echocardiograms were systematically assigned to two members of the panel for pre-review. All echocardiograms subsequently underwent in-person panel adjudication with consensus determination. The panel decision was considered the ?gold standard? for diagnosis. Sensitivity and specificity analyses were used to compare the performance of independent reviewers to the panel adjudication.Results:Echocardiograms from 784 children had both double pre-review and panel adjudication (1568 independent reviews). The overall diagnostic breakdown reflected mild RHD with panel determination of 78 normal/other, 578 borderline RHD, 132 mild definite RHD, and 5 moderate/severe RHD. Independent reviewers had high sensitivity (94%; 95% CI 93-95%) but lower specificity (62%; 95% CI 53-70%) for overall diagnosis (RHD vs. normal). Similarly, for diagnosis of pathological mitral regurgitation, independent reviewers showed high sensitivity (94%; 95% CI 93-95%) but lower specificity (78%, 95% CI 72-82%). In contrast, across all four morphological mitral valve abnormalities in the WHF guidelines, independent reviewers showed lower sensitivity and higher specificity (range 42-64% and 91-97%, respectively). Independent reviewers were quite consistent with the panel on pathological aortic insufficiency (sensitivity 93%, specificity 99%) and abnormal aortic valve morphology (sensitivity 96%, specificity 97%).Conclusions:Compared to the gold standard of panel adjudication of echocardiograms, independent reviewers were more likely to over-diagnose RHD and pathological mitral regurgitation and under-diagnose morphological mitral valve abnormalities. Further work is needed to increase the reliability of the 2012 WHF criteria in order to facilitate consistent implementation for RHD diagnosis around the world.

Published
2019
Full Text
View/download PDF

43. Abstract 15544: Determining the Risk of Developing Rheumatic Heart Disease Following a Negative Screening Echocardiogram

Author

Zimmerman, Meghan, Scheel, Amy, Dewyer, Alyssa, Okello, Emmy, Sable, Craig A, and beaton, Andrea Z

Abstract

Introduction:Active case detection using screening echocardiography (echo) has high sensitivity for rheumatic heart disease (RHD). Most children with echo-detected RHD have mild disease, offering a chance to limit progression through secondary prophylaxis. However, implementation of screening programs in RHD endemic areas presents challenges given limited resources. Timing of screening remains an unexplored question. Here, we begin to address screening intervals by assessing risk of RHD among previous screen-negative children in Northern Uganda.Methods:Between June and October 2018, a large school-based echo screening was conducted in Gulu, Uganda and surrounding districts. Prior echo screenings had occurred in the same region in 2013 and 2014. A short 4-question interview was conducted, allowing children to self-identify as having prior screening. All children who self-reported were verified by checking the class and school they reported attending at the prior screening. Additionally, a subset (33%) of the sample was manually cross-checked by name, age, school and grade, to ensure adequacy of recall. Relative risk of RHD was calculated for those with a prior negative screening compared to those undergoing first screening.Results:Echo screening was completed in 102,400 children with 1,608 reporting a previous screening (44-61 months prior). Of the 528 children manually cross-checked, all were confirmed to have participated in a prior program. RHD was diagnosed in 1,099 children (1.1%), 10 (10/1608, 0.6%) of whom were previously screen-negative. The relative risk of RHD in children who have had a negative screening echo compared to those who were never previously screened was 0.58 (95% CI 0.3-1).Conclusions:Children who have a screen-negative echo have a low likelihood of developing RHD over a 4-5 year timeframe. While not reaching significance, prior screen-negative children in our cohort had a nearly 50% lower risk of RHD, indicating a strategy focused on a single screening may be practical. While verification is needed with larger sample sizes, these data provide the first information about a child?s risk of RHD following a negative echo screen and add to the growing implementation literature around this public health approach.

Published
2019
Full Text
View/download PDF

44. Quality of Life in Ugandan Children and Young Adults After Surgery for Congenital Heart Disease: Mixed Methods Approach.

Author

Searchinger C, Nalubwama H, Pulle J, Mehta R, Tumwbaze H, Kyarimpa R, Mwima R, Atukunda E, Bua B, Sarnacki R, Sherman MG, Oketcho M, Zimmerman M, Nakitto M, Longenecker CT, Webel A, Scheel A, Lwabi PS, and Sable CA

Subjects
Humans, Child, Young Adult, Adolescent, Adult, Child, Preschool, Uganda epidemiology, Cross-Sectional Studies, Health Status, Surveys and Questionnaires, Quality of Life psychology, Heart Defects, Congenital surgery
Abstract

Background: Health-related quality of life (HRQOL) is a critical issue for patients undergoing surgery for congenital heart disease (CHD) but has never been assessed in a low-income country. We conducted a cross-sectional mixed methods study with age-matched healthy siblings serving as controls at the Uganda Heart Institute., Methods: One-hundred fifteen CHD pediatric and young adult patients and sibling control participants were recruited. Health-related quality of life was assessed using the Pediatric Quality of Life Inventory Version 4.0 in participants ages 5-17 and 36-Item Short Form Survey for young adults aged 18-25. A subset of 27 participants completed face-to-face interviews to supplement quantitative findings., Results: Eighty-six pediatric (age 5-17) sibling and parent pairs completed Peds QOL surveys, and 29 young adult (age 18-25) sibling pairs completed SF-36 surveys. One third of patients had surgery in Uganda. Ventricular septal defects and tetralogy of Fallot were the most common diagnoses. Health-related quality of life scores in patients were lower across all domains compared to control participants in children. Reductions in physical and emotional domains of HRQOL were also statistically significant for young adults. Variables associated with lower HRQOL score on multivariate analysis in pediatric patients were younger age in the physical and emotional domains, greater number of surgeries in the physical domain and surgery outside Uganda in the school domain. The only predictor of lower HRQOL score in young adults was surgery outside Uganda in the social domain. Qualitative interviews identified a number of themes that correlated with survey results including abandonment by family, isolation from peers and community, financial hardship and social stigmatization., Conclusion: Health-related quality of life was lower in Ugandan patients after CHD surgery than siblings. Younger patients and those who had surgery outside of Uganda had lower HRQOL. These data have important implications for patients undergoing CHD surgery in LMIC and have potential to inform interventions., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2024 The Author(s).)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results