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243 results on '"Scheer I"'

1. What harm does a second delivery to the pelvic floor?

Author

Jundt K, Scheer I, von Bodungen V, Krumbachner F, Friese K, and Peschers UM

Subjects
second delivery, pelvic floor, urinary incontinence, anal incontinence, levator ani muscle, Medicine
Abstract

Abstract Objective To compare the pelvic floor function of primiparous women to women after a second delivery regarding symptoms of urinary and anal incontinence, anal sphincter ruptures and bladder-neck mobility. Methods A questionnaire evaluating symptoms of urinary and anal incontinence was used in nulliparous women before and 27 months after childbirth. Furthermore these symptoms were correlated with functional changes of the pelvic floor based on a careful gynecologic examination as well as perineal and endoanal ultrasound. Results 112 nulliparous women were included, 49 women returned for follow-up on average 27 months (SD 4.4 months) after the first delivery. 39 women (group A) had just one delivery, 10 women (group B - 10/49) had had a second delivery. Apart from levator ani muscle strength, no significant difference between pelvic floor function of group A vs group B was demonstrable. Furthermore, we could show no significant difference for symptoms of urinary (11 (28.2%) vs. 5 (50.0%)) and anal incontinence (14 (35.9%) vs. 4 (40.0%)) between both groups. However, we found a lasting increase of stress urinary and anal incontinence as well as overactive bladder symptoms after one or more deliveries. The position of the bladder neck at rest was lower in both groups compared to the position before the first delivery and bladder neck mobility increased after one or more deliveries. Discussion Our study shows several statistically significant changes of the pelvic floor function even on average 27 months after delivery, but a subsequent delivery did not compromise the pelvic floor any further.

Published
2010
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2. Incontinence, bladder neck mobility, and sphincter ruptures in primiparous women

Author

Jundt K, Scheer I, Schiessl B, Karl K, Friese K, and Peschers UM

Subjects
pelvic floor, childbirth, urinary incontinence, anal incontinence, levator ani muscle, Medicine
Abstract

Abstract Objective To compare the function of the pelvic floor in primiparae before and during pregnancy with the status post partum concerning symptoms of incontinence, sphincter ruptures, bladder-neck mobility and the influence of the different modes of deliveries. Methods Questionnaire evaluating symptoms of urinary and anal incontinence in nulliparous women before and after delivery and correlating these symptoms with functional changes of the pelvic floor based on a careful gynaecologic examination as well as perineal and endoanal ultrasound. Results 112 women were included in our study and came for the first visit, 99 women returned for follow-up 6 months after childbirth. Stress and flatus incontinence significantly increased from before pregnancy (3 and 12%) to after childbirth (21 and 28%) in women with spontaneous delivery or vacuum extraction. No new symptoms occurred after c-section. There was no significant difference between the bladder neck position before and after delivery. The mobility of the bladder neck was significantly higher after vaginal delivery using a vacuum extraction compared to spontaneous delivery or c-section. The bladder neck in women with post partum urinary stress incontinence was significantly more mobile than in continent controls. The endoanal ultrasound detected seven occult sphincter defects without any correlation to symptoms of anal incontinence. Conclusion Several statistically significant changes of the pelvic floor after delivery were demonstrated. Spontaneous vaginal delivery or vacuum extraction increases the risk for stress or anal incontinence, delivery with vacuum extraction leads to higher bladder neck mobility and stress incontinent women have more mobile bladder necks than continent women.

Published
2010
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5. Données d’efficacité et de survie en vie réelle de patients atteints d’un carcinome épidermoïde cutané évolué sous anti-PD(L)-1 en première ligne de traitement

Author

Quéreux, G., Scheer, I., Leroy, M., Zehou, O., Gaudy-Marqueste, C., Beylot-Barry, M., Peuvrel, L., Montaudié, H., Lesage, C., Mansard, S., Granel-Brocard, F., Aubin, F., Duval-Modeste, A.B., Bens, G., Beneton, N., Basset-Seguin, N., Mortier, L., and Maubec, E.

Abstract

Notre base recueille les cas de carcinomes épidermoïdes cutanés (CEC) traités par voie systémique depuis 2020. Nous avions montré chez les 142 premiers patients que ceux-ci étaient caractérisés par une fréquence élevée de patients immunodéprimés et de patients avec un PS altéré et que les anti-PD-1 étaient administrés en 1religne dans la majorité des cas. Nous actualisons les données et présentons pour la première fois les données de réponse et de survie des patients sous anti-PD(L)-1.

Published
2024
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11. Anti-PD-1 pour le traitement d’un carcinome épidermoïde avancé chez les transplantés d’organes

Author

Gaudy-Marqueste, C., Lesage, C., Leroy, M., Scheer, I., Quéreux, G., Beylot-Barry, M., Montaudié, H., Mortier, L., and Maubec, E.

Abstract

Les transplantés d’organes (TP) ont un risque accru de carcinomes épidermoïdes avancés (CECa). En raison du risque de rejet de greffe, les TP sont souvent exclus des essais. Il y a peu de données chez les TP atteints de CECa traités par anti-PD-1.

Published
2024
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12. CRIM-negative infantile Pompe disease: 42-month treatment outcome

Author

Rohrbach, M, Klein, A, Köhli-Wiesner, A, Veraguth, D, Scheer, I, Balmer, C, Lauener, R, Baumgartner, M R, University of Zurich, and Rohrbach, M

Subjects
2716 Genetics (clinical), 1311 Genetics, 10036 Medical Clinic, 610 Medicine & health, 10045 Clinic for Otorhinolaryngology
Abstract

Pompe disease is a rare lysosomal glycogen storage disorder characterized by deficiency of acid α-glucosidase enzyme (GAA) and caused by mutations in the GAA gene. Infantile-type Pompe disease is a multiorgan disorder presenting with cardiomyopathy, hypotonia, and muscular weakness, which is usually fatal. Enzyme replacement therapy (ERT) with recombinant human GAA (rhGAA) has recently been shown to be effective and subsequently yielded promising results in cross-reactive immunologic material (CRIM)-positive patients. CRIM-negative patients showed a limited response to ERT and died or were ventilator dependant. Over a period of 44months, we monitored cognitive and motor development, behavior, auditory function, and brain imaging of a CRIM-negative infantile Pompe disease patient on rhGAA and monoclonal anti-immunoglobulin E (anti-IgE) antibody (omalizumab) treatment due to severe allergic reaction. Cardiorespiratory and skeletal muscle response was significant, with almost normal motor development. Cognitive development—in particular, speech and language—deviated increasingly from normal age-appropriate development and was markedly delayed at 44months, unexplained by moderate sensorineural hearing impairment. Brain magnetic resonance imaging (MRI) at 18, 30, and 44months of age revealed symmetrical signal alteration of the deep white matter. Titer values of IgG antibodies to rhGAA always remained

Published
2018

16. SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

Author

Shaw, N.D., Brand, H., Kupchinsky, Z.A., Bengani, H., Plummer, L., Jones, T.I., Erdin, S., Williamson, K.A., Rainger, J., Stortchevoi, A., Samocha, K., Currall, B.B., Dunican, D.S., Collins, R.L., Willer, J.R., Lek, A., Lek, M., Nassan, M., Pereira, S., Kammin, T., Lucente, D., Silva, A., Seabra, C.M., Chiang, C., An, Y., Ansari, M., Rainger, J.K., Joss, S., Smith, J.C., Lippincott, M.F., Singh, S.S., Patel, N., Jing, J.W., Law, J.R., Ferraro, N., Verloes, A., Rauch, A., Steindl, K., Zweier, M., Scheer, I., Sato, D., Okamoto, N., Jacobsen, C., Tryggestad, J., Chernausek, S., Schimmenti, L.A., Brasseur, B., Cesaretti, C., Garcia-Ortiz, J.E., Buitrago, T.P., Silva, O.P., Hoffman, J.D., Muhlbauer, W., Ruprecht, K.W., Loeys, B.L., Shino, M., Kaindl, A.M., Cho, C.H., Morton, C.C., Meehan, R.R., Heyningen, V. van, Liao, E.C., Balasubramanian, R., Hall, J.E., Seminara, S.B., Macarthur, D., Moore, S.A., Yoshiura, K.I., Gusella, J.F., Marsh, J.A., Graham, J.M., Lin, A.E., Katsanis, N., Jones, P.L., Crowley, W.F., Davis, E.E., FitzPatrick, D.R., Talkowski, M.E., Shaw, N.D., Brand, H., Kupchinsky, Z.A., Bengani, H., Plummer, L., Jones, T.I., Erdin, S., Williamson, K.A., Rainger, J., Stortchevoi, A., Samocha, K., Currall, B.B., Dunican, D.S., Collins, R.L., Willer, J.R., Lek, A., Lek, M., Nassan, M., Pereira, S., Kammin, T., Lucente, D., Silva, A., Seabra, C.M., Chiang, C., An, Y., Ansari, M., Rainger, J.K., Joss, S., Smith, J.C., Lippincott, M.F., Singh, S.S., Patel, N., Jing, J.W., Law, J.R., Ferraro, N., Verloes, A., Rauch, A., Steindl, K., Zweier, M., Scheer, I., Sato, D., Okamoto, N., Jacobsen, C., Tryggestad, J., Chernausek, S., Schimmenti, L.A., Brasseur, B., Cesaretti, C., Garcia-Ortiz, J.E., Buitrago, T.P., Silva, O.P., Hoffman, J.D., Muhlbauer, W., Ruprecht, K.W., Loeys, B.L., Shino, M., Kaindl, A.M., Cho, C.H., Morton, C.C., Meehan, R.R., Heyningen, V. van, Liao, E.C., Balasubramanian, R., Hall, J.E., Seminara, S.B., Macarthur, D., Moore, S.A., Yoshiura, K.I., Gusella, J.F., Marsh, J.A., Graham, J.M., Lin, A.E., Katsanis, N., Jones, P.L., Crowley, W.F., Davis, E.E., FitzPatrick, D.R., and Talkowski, M.E.

Abstract

Item does not contain fulltext, Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders. CRISPR/Cas9-mediated alteration of smchd1 in zebrafish yielded arhinia-relevant phenotypes. Transcriptome and protein analyses in arhinia probands and controls showed no differences in SMCHD1 mRNA or protein abundance but revealed regulatory changes in genes and pathways associated with craniofacial patterning. Mutations in SMCHD1 thus contribute to distinct phenotypic spectra, from craniofacial malformation and reproductive disorders to muscular dystrophy, which we speculate to be consistent with oligogenic mechanisms resulting in pleiotropic outcomes.

Published
2017

17. Currarino-Syndrom: Variabilität der bildgebenden Befunde bei 22 molekulargenetisch identifizierten (HLXB9-Mutation) Patienten aus fünf Familien

Author

Scheer I, André Reis, Oellinger J, Riebel T, and Joachim Köchling

Subjects
medicine.medical_specialty, business.industry, Radiography, Coccyx, Lipoma, Sacrum, medicine.disease, Surgery, medicine.anatomical_structure, Atresia, Medicine, Radiology, Nuclear Medicine and imaging, Differential diagnosis, business, Lumbosacral joint, Currarino syndrome
Abstract

Purpose: The imaging documents, obtained in connection with a primarily molecular genetic study on Currarino syndrome, should be evaluated with special respect to the constancy resp. the variability of findings in patients with proven HLBX9 mutations. Methods: In five female non-related index patients with clinicoradiologically diagnosed Currarino syndrome and further 53 members of their families, changes of the homeobox gene HLXB9 had been analysed. Variable mutations of this gene were found in a total of 23 individuals including the five index patients. In 22 of them the preexisting radiological documents could be collected as well as further imaging (plain sacrococcygeal radiography and/or lumbosacral MRI at least) initiated. This was followed by a detailed evaluation of pathological findings in the os sacrum/coccyx as well as in the presacral, the intraspinal, the anorectal, and the urogenital region, finally. Results: Imaging investigations revealed concomitant phenotypic abnormalities in all and even nine clinically asymptomatic individuals with proven HLXB9 mutations. A sacrococcygeal defect of varying intensity was depicted in every case. Complete Currarino triad (i. e. sacrococcygeal defect, presacral mass = anterior meningocele and/or tumor, anorectal malformation) was only found in the five index patients and three further relatives. In all other cases, one or more of the following anomalies were detected with variable combination and with decreasing frequency: anterior meningocele (12), presacral tumor (11), tethered cord (10), intraspinal lipoma (8), anorectal stenosis/atresia (8), syringocele (5), rectal fistula (3), urogenital (2). Conclusion: Currarino syndrome should be considered as a differential diagnosis in all patients with chronic constipation since early infancy and its imaging index finding, i.e. a sacrococcygeal defect, should be looked for with plain radiography, first. In positive cases or other phenotypic suspicious constellations molecular genetic analysis for HLBX9 mutations should be the next step. If positive again, this should be followed by complete adequate imaging in the patient as well as by plain sacrococcygeal radiography in, at least, symptomatic family members.

Published
2004
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32. Incidental findings of mass lesions on neuroimages in children

Author

Perret, C, Boltshauser, E, Scheer, I, Kellenberger, C J; https://orcid.org/0000-0001-9122-2431, Grotzer, M A, Perret, C, Boltshauser, E, Scheer, I, Kellenberger, C J; https://orcid.org/0000-0001-9122-2431, and Grotzer, M A

Abstract

Increasing use of neuroimaging in children has led to more incidental findings of CNS mass lesions, the management of which is uncertain. The authors' aims in this study are to describe these mass lesions and their evolution, as well as to discuss the management options and determine the prevalence of incidental CNS mass lesions at their pediatric clinic. A retrospective study was undertaken in children with primary CNS tumors who were younger than 18 years old and were admitted to the University Children's Hospital of Zurich, Switzerland, between January 1995 and December 2010. In 19 (5.7%) of 335 patients with newly diagnosed CNS tumors, the diagnosis of a CNS mass lesion was an incidental finding. Reasons for obtaining neuroimages in these 19 patients were head trauma (in 6 patients); research protocols (in 3); nasal/orbital malformations (in 2); endocrinological and psychiatric evaluations (in 2); and vertebral bone anomaly without neurological signs, absence seizures, congenital ataxia, recurrent vomiting, developmental delay, and "check-up" at the explicit request of the parents (in 1 patient each). Seven patients underwent immediate surgery for low-grade glioma (4 patients) and craniopharyngioma, ependymoma, and choroid plexus papilloma (1 patient each); and 12 were treated conservatively or were observed. Ten of 12 conservatively treated patients remained stable (median follow-up time 1.8 years) and the other 2 underwent delayed surgery because of tumor progression (medulloblastoma in one patient and fibrillary astrocytoma in the other). Clinicians are increasingly challenged by the discovery of incidental CNS mass lesions. A subgroup of such lesions (with typical imaging patterns such as tectal glioma and dysembryoplastic neuroepithelial tumor) can be monitored conservatively, clinically, and radiographically. Future prospective studies are needed to define optimal management strategies based on larger collections of natural histories, as well as to assess

Published
2011

33. CRIM-negative infantile Pompe disease: 42-month treatment outcome

Author

Rohrbach, M, Klein, A, Köhli-Wiesner, A, Veraguth, D, Scheer, I, Balmer, C, Lauener, R, Baumgartner, Matthias R; https://orcid.org/0000-0002-9270-0826, Rohrbach, M, Klein, A, Köhli-Wiesner, A, Veraguth, D, Scheer, I, Balmer, C, Lauener, R, and Baumgartner, Matthias R; https://orcid.org/0000-0002-9270-0826

Published
2010

44. RADIOLOGY

Author

Murray, J., primary, Braly, E., additional, Head, H., additional, Donahue, D., additional, Rush, S., additional, Stence, N., additional, Liu, A., additional, Kleinhenz, J., additional, Bison, B., additional, Pietsch, T., additional, von Hoff, K., additional, von Bueren, A., additional, Rutkowski, S., additional, Warmuth-Metz, M., additional, Jaspan, T., additional, Brisse, H., additional, Potepan, P., additional, Berg, F., additional, Gerber, N., additional, Sugiyama, K., additional, Kurisu, K., additional, Kajiwara, Y., additional, Takayasu, T., additional, Saito, T., additional, Hanaya, R., additional, Yamasaki, F., additional, Vicente, J., additional, Fuster-Garcia, E., additional, Tortajada, S., additional, Garcia-Gomez, J. M., additional, Davies, N., additional, Natarajan, K., additional, Wilson, M., additional, Grundy, R. G., additional, Wesseling, P., additional, Monleon, D., additional, Celda, B., additional, Robles, M., additional, Peet, A. C., additional, Perret, C., additional, Boltshauser, E., additional, Scheer, I., additional, Kellenberger, C., additional, Grotzer, M., additional, Steffen-Smith, E., additional, Venzon, D., additional, Bent, R., additional, Baker, E., additional, Shandilya, S., additional, Warren, K., additional, Shih, C.-S., additional, West, J., additional, Ho, C., additional, Porter, D., additional, Wang, Y., additional, Saykin, A., additional, McDonald, B., additional, Arfanakis, K., additional, Vezina, G., additional, Hargrave, D., additional, Poussaint, T. Y., additional, Goldman, S., additional, Packer, R., additional, Wen, P., additional, Pollack, I., additional, Zurakowski, D., additional, Kun, L., additional, Prados, M., additional, Kieran, M., additional, Eckel, L., additional, Keating, G., additional, Giannini, C., additional, Wetjen, N., additional, Patton, A., additional, Sarlls, J., additional, Pierpaoli, C., additional, Walker, L., additional, Perreault, S., additional, Lober, R., additional, Yeom, K., additional, Carret, A.-S., additional, Vogel, H., additional, Partap, S., additional, Fisher, P., additional, Gill, S. K., additional, Davies, N. P., additional, MacPherson, L., additional, Arvanitis, T. N., additional, Gill, S., additional, Arvanitis, T., additional, Peet, A., additional, Hayes, L., additional, Jones, R., additional, Mazewski, C., additional, Aguilera, D., additional, Palasis, S., additional, Bendel, A., additional, Patterson, R., additional, Petronio, J., additional, Meijer, L., additional, Grundy, R. G. G., additional, Walker, D. A., additional, Robison, N., additional, Grant, F., additional, Treves, S. T., additional, Bandopadhayay, P., additional, Manley, P., additional, Chi, S., additional, Zimmerman, M. A., additional, Chordas, C., additional, Goumnerova, L., additional, Smith, E., additional, Scott, M., additional, Ullrich, N. J., additional, Poussaint, T., additional, Yang, J. C., additional, Lightner, D. D., additional, Khakoo, Y., additional, Wolden, S. L., additional, Smee, R., additional, Zhao, C., additional, Spencer-Trotter, B., additional, Hallock, A., additional, Konski, A., additional, Bhambani, K., additional, Mahajan, A., additional, Jones, J., additional, Ketonen, L., additional, Paulino, A., additional, Ater, J., additional, Grosshans, D., additional, Dauser, R., additional, Weinberg, J., additional, Chintagumpala, M., additional, Dvir, R., additional, Elhasid, R., additional, Corn, B., additional, Tempelhoff, H., additional, Matceyevsky, D., additional, Makrin, V., additional, Shtraus, N., additional, Yavetz, D., additional, Constantini, S., additional, Gez, E., additional, Yu, E.-S., additional, Kim, Y.-J., additional, Park, H. J., additional, Kim, H. J., additional, Shin, S. H., additional, Kim, J.-H., additional, Kim, J.-Y., additional, Lee, Y. K., additional, Fiore, M. R., additional, Sanne, C., additional, Mandeville, H. C., additional, Saran, F. H., additional, Greenspoon, J., additional, Duckworth, J., additional, Singh, S., additional, Scheinemann, K., additional, Whitton, A., additional, Gauvain, K., additional, Geller, T., additional, Elbabaa, S., additional, Dombrowski, J., additional, Wong, K., additional, Olch, A., additional, Davidson, T. B., additional, Venkatramani, R., additional, Haley, K., additional, Zaky, W., additional, Dhall, G., additional, Finlay, J., additional, Bishop, M. W., additional, Hummel, T. R., additional, Leach, J., additional, Minturn, J., additional, Breneman, J., additional, Stevenson, C., additional, Wagner, L., additional, Sutton, M., additional, Miles, L., additional, and Fouladi, M., additional

Published
2012
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47. OP14.03: The International Fetal Neurology Network (IFN): a 3-year summary of an online academic videoconferencing collaboration

Author

Rotmensch, S., primary, Prayer, D., additional, Malinger, G., additional, Lerman-Sagie, T., additional, Kainer, F., additional, Pistorius, L., additional, Whitby, E., additional, Scheer, I., additional, Timor-Tritsch, I. E., additional, Sarnat, H., additional, Guibaud, L., additional, Pugash, D., additional, Solt, I., additional, de Vries, J. I., additional, Frisova, V., additional, Aksoy, U., additional, and Lau, G., additional

Published
2011
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