1. Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD
- Author
-
Leitao Filho, Fernando Sergio, Ra, Seung Won, Mattman, Andre, Schellenberg, Robert S, Criner, Gerard J, Woodruff, Prescott G, Lazarus, Stephen C, Albert, Richard, Connett, John E, Han, Meilan K, Martinez, Fernando J, Leung, Janice M, Paul Man, SF, Aaron, Shawn D, Reed, Robert M, Sin, Don D, and for the Canadian Respiratory Research Network (CRRN)
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Trials and Supportive Activities ,Prevention ,Clinical Research ,Lung ,Chronic Obstructive Pulmonary Disease ,Respiratory ,Aged ,Biomarkers ,Double-Blind Method ,Female ,Hospitalization ,Humans ,IgG Deficiency ,Immunoglobulin G ,Male ,Middle Aged ,Pulmonary Disease ,Chronic Obstructive ,Retrospective Studies ,Risk Factors ,IgG ,IgG subclass deficiency ,COPD ,Exacerbation ,Canadian Respiratory Research Network ,Cardiorespiratory Medicine and Haematology ,Respiratory System ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
BackgroundThe literature is scarce regarding the prevalence and clinical impact of IgG subclass deficiency in COPD. We investigated the prevalence of IgG subclass deficiencies and their association with exacerbations and hospitalizations using subjects from two COPD cohorts.MethodsWe measured IgG subclass levels using immunonephelometry in serum samples from participants enrolled in two previous COPD trials: Macrolide Azithromycin for Prevention of Exacerbations of COPD (MACRO; n = 976) and Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD (STATCOPE; n = 653). All samples were collected from clinically stable participants upon entry into both studies. IgG subclass deficiency was diagnosed when IgG subclass levels were below their respective lower limit of normal: IgG1
- Published
- 2018