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1,198 results on '"Schetelig, Johannes"'

1. Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT

Author

Guièze, Romain, Eikema, Diderik-Jan, Koster, Linda, Schetelig, Johannes, Sengeloev, Henrik, Passweg, Jakob, Finke, Jürgen, Arat, Mutlu, Broers, Annoek E. C., Stölzel, Friedrich, Byrne, Jenny, Castilla-Llorente, Cristina, Dreger, Peter, Eder, Matthias, Gedde-Dahl, Tobias, Kröger, Nicolaus, Ribera Santasusana, Josep Maria, Richardson, Deborah, Rambaldi, Alessandro, Yañez, Lucrecia, Van Gelder, Michel, Drozd-Sokolowska, Joanna, Raj, Kavita, Yakoub-Agha, Ibrahim, Tournilhac, Olivier, and McLornan, Donal P.

Published
2024
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2. Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: a report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT

Author

Sureda, Anna, Carpenter, Paul A., Bacigalupo, Andrea, Bhatt, Vijaya Raj, de la Fuente, Josu, Ho, Aloysius, Kean, Leslie, Lee, Jong Wook, Sánchez-Ortega, Isabel, Savani, Bipin N., Schetelig, Johannes, Stadtmauer, Edward A., Takahashi, Yoshiyuki, Atsuta, Yoshiko, Koreth, John, Kröger, Nicolaus, Ljungman, Per, Okamoto, Shinichiro, Popat, Uday, Soiffer, Robert, Stefanski, Heather E., and Kharfan-Dabaja, Mohamed A.

Published
2024
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3. Chronic Lymphocytic Leukemia

Author

Schetelig, Johannes, Dreger, Peter, Sureda, Anna, editor, Corbacioglu, Selim, editor, Greco, Raffaella, editor, Kröger, Nicolaus, editor, and Carreras, Enric, editor

Published
2024
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4. Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial

Author

Al-Sawaf, Othman, Ligtvoet, Rudy, Robrecht, Sandra, Stumpf, Janina, Fink, Anna-Maria, Tausch, Eugen, Schneider, Christof, Boettcher, Sebastian, Mikusko, Martin, Ritgen, Matthias, Schetelig, Johannes, von Tresckow, Julia, Vehling-Kaiser, Ursula, Gaska, Tobias, Wendtner, Clemens Martin, Chapuy, Bjoern, Fischer, Kirsten, Kreuzer, Karl-Anton, Stilgenbauer, Stephan, Staber, Philipp, Niemann, Carsten, Hallek, Michael, and Eichhorst, Barbara

Published
2024
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6. Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Petzold, Andreas, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Oelschlägel, Uta, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Dahl, Andreas, Schetelig, Johannes, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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7. Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification

Author

Eckardt, Jan-Niklas, Bill, Marius, Rausch, Christian, Metzeler, Klaus, Spiekermann, Karsten, Stasik, Sebastian, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Krug, Utz, Wörmann, Bernhard, Hiddemann, Wolfgang, Görlich, Dennis, Sauerland, Cristina, Steffen, Björn, Einsele, Hermann, Neubauer, Andreas, Burchert, Andreas, Schäfer-Eckart, Kerstin, Berdel, Wolfgang E., Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Fransecky, Lars, Braess, Jan, Ruhnke, Leo, Schetelig, Johannes, Middeke, Jan Moritz, Serve, Hubert, Baldus, Claudia D., Platzbecker, Uwe, Müller-Tidow, Carsten, Bornhäuser, Martin, Herold, Tobias, Thiede, Christian, and Röllig, Christoph

Published
2023
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8. Anti-CD3/CD7 immunoconjugate (T-Guard) for severe, steroid-refractory GVHD: final report of BMT CTN 2002

Author

Meyers, Gabrielle, Hamadani, Mehdi, Martens, Michael, Ali, Haris, Chevallier, Patrice, Choe, Hannah, Harris, Andrew C., Holler, Ernst, van Hooren, Eric, Klaassen, Willem, Leifer, Eric, van Oosterhout, Ypke, Perez, Lia, Pusic, Iskra, Stelljes, Matthias, van der Velden, Walter, Ammatuna, Emanuele, Beauvais, David, Cornillon, Jérôme, Maziarz, Richard T., Schetelig, Johannes, Romeril, Jennifer, MacMillan, Margaret L., Levine, John E., and Socié, Gérard

Published
2023
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9. UBTF tandem duplications are rare but recurrent alterations in adult AML and associated with younger age, myelodysplasia, and inferior outcome

Author

Georgi, Julia-Annabell, Stasik, Sebastian, Eckardt, Jan-Niklas, Zukunft, Sven, Hartwig, Marita, Röllig, Christoph, Middeke, Jan Moritz, Oelschlägel, Uta, Krug, Utz, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Kroschinsky, Frank, and Thiede, Christian

Published
2023
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10. Unsupervised meta-clustering identifies risk clusters in acute myeloid leukemia based on clinical and genetic profiles

Author

Eckardt, Jan-Niklas, Röllig, Christoph, Metzeler, Klaus, Heisig, Peter, Stasik, Sebastian, Georgi, Julia-Annabell, Kroschinsky, Frank, Stölzel, Friedrich, Platzbecker, Uwe, Spiekermann, Karsten, Krug, Utz, Braess, Jan, Görlich, Dennis, Sauerland, Cristina, Woermann, Bernhard, Herold, Tobias, Hiddemann, Wolfgang, Müller-Tidow, Carsten, Serve, Hubert, Baldus, Claudia D., Schäfer-Eckart, Kerstin, Kaufmann, Martin, Krause, Stefan W., Hänel, Mathias, Berdel, Wolfgang E., Schliemann, Christoph, Mayer, Jiri, Hanoun, Maher, Schetelig, Johannes, Wendt, Karsten, Bornhäuser, Martin, Thiede, Christian, and Middeke, Jan Moritz

Published
2023
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11. Alterations of cohesin complex genes in acute myeloid leukemia: differential co-mutations, clinical presentation and impact on outcome

Author

Eckardt, Jan-Niklas, Stasik, Sebastian, Röllig, Christoph, Sauer, Tim, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Cerqueira, Tiago, Kroschinsky, Frank, Berdel, Wolfgang E., Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Siepmann, Timo, Bornhäuser, Martin, Middeke, Jan Moritz, and Thiede, Christian

Published
2023
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12. Acalabrutinib, venetoclax, and obinutuzumab in relapsed/refractory CLL: final efficacy and ctDNA analysis of the CLL2-BAAG trial

Author

Fürstenau, Moritz, Giza, Adam, Weiss, Jonathan, Kleinert, Fanni, Robrecht, Sandra, Franzen, Fabian, Stumpf, Janina, Langerbeins, Petra, Al-Sawaf, Othman, Simon, Florian, Fink, Anna-Maria, Schneider, Christof, Tausch, Eugen, Schetelig, Johannes, Dreger, Peter, Böttcher, Sebastian, Fischer, Kirsten, Kreuzer, Karl-Anton, Ritgen, Matthias, Schilhabel, Anke, Brüggemann, Monika, Stilgenbauer, Stephan, Eichhorst, Barbara, Hallek, Michael, and Cramer, Paula

Published
2024
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14. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, Wendelin, Knut, Middeke, Jan Moritz, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Krause, Stefan W, Klein, Stefan A, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Kriege, Oliver, Berdel, Wolfgang E, Ehninger, Gerhard, and Schmidt, Alexander H

Published
2024
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15. Six-year follow-up and subgroup analyses of a phase 2 trial of venetoclax for del(17p) chronic lymphocytic leukemia

Author

Stilgenbauer, Stephan, Tausch, Eugen, Roberts, Andrew W., Davids, Matthew S., Eichhorst, Barbara, Hallek, Michael, Hillmen, Peter, Schneider, Christof, Schetelig, Johannes, Böttcher, Sebastian, Kater, Arnon P., Jiang, Yanwen, Boyer, Michelle, Popovic, Relja, Ghanim, Majd T., Moran, Michael, Sinai, Wendy J., Wang, Xifeng, Mukherjee, Nabanita, Chyla, Brenda, Wierda, William G., and Seymour, John F.

Published
2024
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17. Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML

Author

Fein, Joshua A., Shouval, Roni, Krieger, Elizabeth, Spellman, Stephen R., Wang, Tao, Baldauf, Henning, Fleischhauer, Katharina, Kröger, Nicolaus, Horowitz, Mary, Maiers, Martin, Miller, Jeffrey S, Mohty, Mohamad, Nagler, Arnon, Weisdorf, Daniel, Malmberg, Karl-Johan, Toor, Amir A., Schetelig, Johannes, Romee, Rizwan, and Koreth, John

Published
2024
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18. Donor selection for KIR alloreactivity is associated with superior survival in haploidentical transplant with PTCy

Author

Zou, Jun, Kongtim, Piyanuch, Srour, Samer A, Greenbaum, Uri, Schetelig, Johannes, Heidenreich, Falk, Baldauf, Henning, Moore, Brandt, Saengboon, Supawee, Carmazzi, Yudith, Rondon, Gabriela, Ma, Qing, Rezvani, Katayoun, Shpall, Elizabeth J, Champlin, Richard E, Ciurea, Stefan O, and Cao, Kai

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Regenerative Medicine, Transplantation, Clinical Research, Humans, Middle Aged, Donor Selection, Transplantation Conditioning, Transplantation, Haploidentical, Receptors, KIR, Cyclophosphamide, haplo-HSCT, NK cell alloreactivity, KIR, donor selection, overall survival, progression-free survival, Immunology, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

With the continuous increase in the use of haploidentical donors for transplantation, the selection of donors becomes increasingly important. Haploidentical donors have been selected primarily based on clinical characteristics, while the effects of killer cell immunoglobulin-like receptors (KIRs) on outcomes of haploidentical-hematopoietic stem cell transplantation (haplo-HSCT) with post-transplant cyclophosphamide (PTCy) remain inconclusive. The present study aimed to thoroughly evaluate the effect of KIRs and binding ligands assessed by various models, in addition to other patient/donor variables, on clinical outcomes in haplo-HSCT. In a cohort of 354 patients undergoing their first haplo-HSCT, we found that a higher Count Functional inhibitory KIR score (CF-iKIR) was associated with improved progression-free survival (adjusted hazard ratio [HR], 0.71; P = .029) and overall survival (OS) (HR, 0.66; P = .016), while none of the other models predicted for survival in these patients. Moreover, using exploratory classification and regression tree analysis, we found that donor age 58 years was associated with the worst OS. In the rest of our cohort (80%), cytomegalovirus-reactive recipients with a donor

Published
2022

20. Genetics of HLA Peptide Presentation and Impact on Outcomes in HLA-Matched Allogeneic Hematopoietic Cell Transplantation

Author

Story, Charlotte McIlwaine, Wang, Tao, Bhatt, Vijaya Raj, Battiwalla, Minoo, Badawy, Sherif M, Kamoun, Malek, Gragert, Loren, Brown, Valerie, Baxter-Lowe, Lee Ann, Marsh, Steven GE, Gadalla, Shahinaz M, Schetelig, Johannes, Mytilineos, Joannis, Miklos, David, Waller, Edmund K, Kuxhausen, Michelle, Spellman, Stephen, Lee, Stephanie, Paczesny, Sophie, Lansford, Jefferson L, Vincent, Benjamin G, Riches, Marcie L, Armistead, Paul M, and Committee, Center for International Blood and Marrow Transplant Research Immunobiology Working

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Immunology, Prevention, Transplantation, Clinical Research, Good Health and Well Being, Hematopoietic Stem Cell Transplantation, Humans, Neoplasm Recurrence, Local, Peptides, Retrospective Studies, Unrelated Donors, Center for International Blood and Marrow Transplant Research Immunobiology Working Committee, Graft-versus-host disease, HLA, Minor histocompatibility antigen, Peptide epitope binding, Clinical Sciences, Cardiovascular medicine and haematology
Abstract

Minor histocompatibility antigens (mHAs), recipient-derived peptide epitopes presented on the cell surface, are known to mediate graft-versus-host disease (GVHD); however, there are no current methods to associate mHA features with GVHD risk. This deficiency is due in part to the lack of technological means to accurately predict, let alone confirm, the tremendous number of potential mHAs in each individual transplant. Previous studies have shown that different HLA molecules present varying fractions of candidate peptide epitopes; however, the genetic "distance" between HLA-matched donors and recipients is relatively constrained. From these 2 observations, it is possible that the HLA type for a donor-recipient pair (DRP) would provide a surrogate measurement of the number of predicted mHAs, which could be related to GVHD risk. Because different HLA molecules present variable numbers of peptide antigens, a predicted cumulative peptide-binding efficiency can be calculated for individual DRP based on the pair's HLA type. The purpose of this study was to test whether cumulative peptide-binding efficiency is associated with the risk of acute GVHD (aGVHD) or relapse. In this retrospective Center for International Blood and Marrow Transplant Research study, a total of 3242 HLA-matched DRPs were analyzed for predicted cumulative peptide-binding efficiency using their HLA types and were divided into tertiles based on their scores. Univariable and multivariable analyses was performed to test for associations between cumulative peptide-binding efficiency for DRPs, divided into the HLA-matched related donor (MRD) and HLA-matched unrelated donor (MUD) cohorts, and the primary outcomes of aGVHD and relapse. Secondary outcomes investigated included overall survival, disease-free survival, and transplantation-related mortality. Using a computationally generated peptidome as a test dataset, the tested series of HLA class I displayed peptide-binding frequencies ranging from 0.1% to 3.8% of the full peptidome, and HLA class II molecules had peptide-binding frequencies of 12% to 77% across the HLA-DRB1 allotypes. By increasing binding efficiency tertile, the cumulative incidence of aGVHD at 6 months for MUD patients was 41%, 41%, and 45% for HLA class I (P = .336) and 44%, 41%, and 42% for HLA class II (P = .452). The cumulative incidences of relapse at 3 years for MUD transplant recipients were 36%, 38%, and 38% for HLA class I (P = .533) and 37%, 37%, and 38% for HLA class II (P = .896). The findings were similar for MRD transplant recipients. Multivariable analysis did not identify any impact of peptide-binding efficiency on aGVHD or relapse in MUD or MRD transplant recipients. Whereas GVHD is mediated by minor antigen mismatches in the context of HLA-matched allo-HCT, peptide-binding efficiency, which was used as a surrogate measurement for predicted number of binding antigens, did not provide additional clinical information for GVHD risk assessment. The negative result may be due to the limitations of this surrogate marker, or it is possible that GVHD is driven by a subset of immunogenic mHAs. Further research should be directed at direct mHA epitope and immunogenicity prediction.

Published
2021

21. Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.

Author

Guethlein, Lisbeth A, Beyzaie, Niassan, Nemat-Gorgani, Neda, Wang, Tao, Ramesh, Vidhyalakshmi, Marin, Wesley M, Hollenbach, Jill A, Schetelig, Johannes, Spellman, Stephen R, Marsh, Steven GE, Cooley, Sarah, Weisdorf, Daniel J, Norman, Paul J, Miller, Jeffrey S, and Parham, Peter

Subjects
Cancer, Rare Diseases, Hematology, Transplantation, Genetics, Genotype, HLA Antigens, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Myeloid, Acute, Receptors, KIR, Recurrence, Immunology
Abstract

In the treatment of acute myelogenous leukemia with allogeneic hematopoietic cell transplantation, we previously demonstrated that there is a greater protection from relapse of leukemia when the hematopoietic cell transplantation donor has either the Cen B/B KIR genotype or a genotype having two or more KIR B gene segments. In those earlier analyses, KIR genotyping could only be assessed at the low resolution of gene presence or absence. To give the analysis greater depth, we developed high-resolution KIR sequence-based typing that defines all the KIR alleles and distinguishes the expressed alleles from those that are not expressed. We now describe and analyze high-resolution KIR genotypes for 890 donors of this human transplant cohort. Cen B01 and Cen B02 are the common CenB haplotypes, with Cen B02 having evolved from Cen B01 by deletion of the KIR2DL5, 2DS3/5, 2DP1, and 2DL1 genes. We observed a consistent trend for Cen B02 to provide stronger protection against relapse than Cen B01 This correlation indicates that protection depends on the donor having inhibitory KIR2DL2 and/or activating KIR2DS2, and is enhanced by the donor lacking inhibitory KIR2DL1, 2DL3, and 3DL1. High-resolution KIR typing has allowed us to compare the strength of the interactions between the recipient's HLA class I and the KIR expressed by the donor-derived NK cells and T cells, but no clinically significant interactions were observed. The trend observed between donor Cen B02 and reduced relapse of leukemia points to the value of studying ever larger transplant cohorts.

Published
2021

23. Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence

Author

Eckardt, Jan-Niklas, Hahn, Waldemar, Röllig, Christoph, Stasik, Sebastian, Platzbecker, Uwe, Müller-Tidow, Carsten, Serve, Hubert, Baldus, Claudia D., Schliemann, Christoph, Schäfer-Eckart, Kerstin, Hanoun, Maher, Kaufmann, Martin, Burchert, Andreas, Thiede, Christian, Schetelig, Johannes, Sedlmayr, Martin, Bornhäuser, Martin, Wolfien, Markus, and Middeke, Jan Moritz

Published
2024
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24. Supplementary Tables 1 from Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study

Author

Bazarbachi, Ali, primary, Labopin, Myriam, primary, Moukalled, Nour, primary, Kröger, Nicolaus, primary, Rautenberg, Christina, primary, Schetelig, Johannes, primary, Finke, Jürgen, primary, Blau, Igor Wolfgang, primary, Blaise, Didier, primary, Stelljes, Matthias, primary, Eder, Matthias, primary, Platzbecker, Uwe, primary, Dreger, Peter, primary, Bethge, Wolfgang, primary, Tischer, Johanna, primary, Burns, David, primary, Sengeloev, Henrik, primary, Brissot, Eolia, primary, Giebel, Sebastian, primary, Nagler, Arnon, primary, Ciceri, Fabio, primary, and Mohty, Mohamad, primary

Published
2024
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25. Data from Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study

Author

Bazarbachi, Ali, primary, Labopin, Myriam, primary, Moukalled, Nour, primary, Kröger, Nicolaus, primary, Rautenberg, Christina, primary, Schetelig, Johannes, primary, Finke, Jürgen, primary, Blau, Igor Wolfgang, primary, Blaise, Didier, primary, Stelljes, Matthias, primary, Eder, Matthias, primary, Platzbecker, Uwe, primary, Dreger, Peter, primary, Bethge, Wolfgang, primary, Tischer, Johanna, primary, Burns, David, primary, Sengeloev, Henrik, primary, Brissot, Eolia, primary, Giebel, Sebastian, primary, Nagler, Arnon, primary, Ciceri, Fabio, primary, and Mohty, Mohamad, primary

Published
2024
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26. Supplementary Figure 1 from Improvements in Posttransplant Outcomes Over Two Decades in Older Patients with Acute Myeloid Leukemia in the EBMT ALWP Study

Author

Bazarbachi, Ali, primary, Labopin, Myriam, primary, Moukalled, Nour, primary, Kröger, Nicolaus, primary, Rautenberg, Christina, primary, Schetelig, Johannes, primary, Finke, Jürgen, primary, Blau, Igor Wolfgang, primary, Blaise, Didier, primary, Stelljes, Matthias, primary, Eder, Matthias, primary, Platzbecker, Uwe, primary, Dreger, Peter, primary, Bethge, Wolfgang, primary, Tischer, Johanna, primary, Burns, David, primary, Sengeloev, Henrik, primary, Brissot, Eolia, primary, Giebel, Sebastian, primary, Nagler, Arnon, primary, Ciceri, Fabio, primary, and Mohty, Mohamad, primary

Published
2024
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27. Large case-control study indicates no association of KIR genotype and risk of developing acute myeloid leukemia

Author

Heidenreich, Falk, Falk, Bose, Baldauf, Henning, Massalski, Carolin, Schäfer, Gesine, Rücker-Braun, Elke, Altmann, Heidi, Sauter, Jürgen, Solloch, Ute V., Lange, Vinzenz, Stölzel, Friedrich, Röllig, Christoph, Middeke, Jan M., von Bonin, Malte, Thiede, Christian, Schäfer-Eckart, Kerstin, Müller-Tidow, Carsten, Krause, Stefan W., Kraus, Sabrina, Kaufmann, Martin, Hänel, Mathias, Serve, Hubert, Neubauer, Andreas, Bornhäuser, Martin, Schmidt, Alexander H., and Schetelig, Johannes

Published
2023
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30. Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial

Author

Stelljes, Matthias, Middeke, Jan Moritz, Bug, Gesine, Wagner-Drouet, Eva-Maria, Müller, Lutz P, Schmid, Christoph, Krause, Stefan W, Bethge, Wolfgang, Jost, Edgar, Platzbecker, Uwe, Klein, Stefan A, Schubert, Jörg, Niederland, Judith, Kaufmann, Martin, Schäfer-Eckart, Kerstin, Schaich, Markus, Baldauf, Henning, Stölzel, Friedrich, Petzold, Cathleen, Röllig, Christoph, Alakel, Nael, Steffen, Björn, Hauptrock, Beate, Schliemann, Christoph, Sockel, Katja, Lang, Fabian, Kriege, Oliver, Schaffrath, Judith, Reicherts, Christian, Berdel, Wolfgang E, Serve, Hubert, Ehninger, Gerhard, Schmidt, Alexander H, Bornhäuser, Martin, Mikesch, Jan-Henrik, Schetelig, Johannes, Alakel, Nael, Albring, Jörn, Berdel, Wolfgang E., Bethge, Wolfgang, Bornhäuser, Martin, Bug, Gesine, Buhl, Christoph, Call, Simon, Crysandt, Martina, Egger-Heidrich, Katharina, Eßeling, Eva, Faul, Christoph, Franke, Georg-Nikolaus, Georgi, Julia-Annabell, Glück-Wolf, Julia, Groth, Christoph, Hauptrock, Beate, Heidenreich, Daniela, Janjetovic, Snjezana, Jost, Edgar, Kaufmann, Martin, Kindler, Thomas, Klein, Stefan A., Krause, Stefan W., Kreil, Sebastian, Kretschmann, Theresa, Kunadt, Desiree, Lang, Fabian, Lenz, Georg, Martin, Sonja, Marx, Julia, Middeke, Jan-Moritz, Mikesch, Jan-Henrik, Müller, Lutz P., Müller, Nadine, Niederland, Judith, Parmentier, Stefani, Petzold, Kathrin, Platzbecker, Uwe, Rank, Andreas, Reicherts, Christian, Röllig, Christoph, Rösler, Wolf, Schäfer-Eckart, Kerstin, Schaffrath, Judith, Schaich, Markus, Schetelig, Johannes, Schliemann, Christoph, Schmid, Christoph, Schneidawind, Dominik, Schubert, Jörg, Serve, Hubert, Sockel, Katja, Steffen, Björn, Stelljes, Matthias, Teipel, Raphael, von Bonin, Malte, Wagner-Drouet, Eva, Wass, Maxi, and Wendelin, Knut

Abstract

Whether high-dose cytarabine-based salvage chemotherapy, administered to induce complete remission in patients with poor responsive or relapsed acute myeloid leukaemia scheduled for allogeneic haematopoietic stem-cell transplantation (HSCT) after intensive conditioning confers a survival advantage, is unclear.

Published
2024
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32. Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight

Author

Schetelig, Johannes, primary, Baldauf, Henning, additional, Heidenreich, Falk, additional, Hoogenboom, Jorinde D., additional, Spellman, Stephen R., additional, Kulagin, Alexander, additional, Schroeder, Thomas, additional, Sengeloev, Henrik, additional, Dreger, Peter, additional, Forcade, Edouard, additional, Vydra, Jan, additional, Wagner-Drouet, Eva Maria, additional, Choi, Goda, additional, Paneesha, Shankara, additional, Miranda, Nuno A. A., additional, Tanase, Alina, additional, de Wreede, Liesbeth C., additional, Lange, Vinzenz, additional, Schmidt, Alexander H., additional, Sauter, Jürgen, additional, Fein, Joshua A., additional, Bolon, Yung-Tsi, additional, He, Meilun, additional, Marsh, Steven G. E., additional, Gadalla, Shahinaz M., additional, Paczesny, Sophie, additional, Ruggeri, Annalisa, additional, Chabannon, Christian, additional, and Fleischhauer, Katharina, additional

Published
2024
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33. Calcineurin Inhibitor-Free Graft-Versus-Host Disease (GVHD) Prophylaxis in Hematopoietic Cell Transplantation (HCT) with Myeloablative Conditioning Regimens (MAC) and HLA-Matched Donors: Long Term Follow up of BMT CTN 1301 Progress II Trial

Author

Pasquini, Marcelo C., primary, Soiffer, Robert, additional, Logan, Brent, additional, Kaur, Manmeet, additional, Devine, Steven M., additional, Geller, Nancy, additional, Giralt, Sergio A., additional, Heslop, Helen E., additional, Horowitz, Mary M., additional, Litzow, Mark R., additional, Mendizabal, Adam, additional, Muffly, Lori S, additional, Nemecek, Eneida, additional, O'Donnell, Lynn C., additional, Schetelig, Johannes, additional, Shune, Leyla, additional, Solomon, Scott R., additional, Vasu, Sumithira, additional, Ho, Dr. Vincent T., additional, Perales, Miguel-Angel, additional, and Luznik, Leo, additional

Published
2024
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34. Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

Author

Eckardt, Jan-Niklas, Schmittmann, Tim, Riechert, Sebastian, Kramer, Michael, Sulaiman, Anas Shekh, Sockel, Katja, Kroschinsky, Frank, Schetelig, Johannes, Wagenführ, Lisa, Schuler, Ulrich, Platzbecker, Uwe, Thiede, Christian, Stölzel, Friedrich, Röllig, Christoph, Bornhäuser, Martin, Wendt, Karsten, and Middeke, Jan Moritz

Published
2022
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35. Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Author

Kunadt, Desiree, Stasik, Sebastian, Metzeler, Klaus H., Röllig, Christoph, Schliemann, Christoph, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Scholl, Sebastian, Hilgendorf, Inken, Brümmendorf, Tim H., Jost, Edgar, Steffen, Björn, Bug, Gesine, Einsele, Hermann, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Krause, Stefan W., Hänel, Mathias, Hanoun, Maher, Kaufmann, Martin, Wörmann, Bernhard, Kramer, Michael, Sockel, Katja, Egger-Heidrich, Katharina, Herold, Tobias, Ehninger, Gerhard, Burchert, Andreas, Platzbecker, Uwe, Berdel, Wolfgang E., Müller-Tidow, Carsten, Hiddemann, Wolfgang, Serve, Hubert, Stelljes, Matthias, Baldus, Claudia D., Neubauer, Andreas, Schetelig, Johannes, Thiede, Christian, Bornhäuser, Martin, Middeke, Jan M., and Stölzel, Friedrich

Published
2022
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36. Molecular profiling and clinical implications of patients with acute myeloid leukemia and extramedullary manifestations

Author

Eckardt, Jan-Niklas, Stölzel, Friedrich, Kunadt, Desiree, Röllig, Christoph, Stasik, Sebastian, Wagenführ, Lisa, Jöhrens, Korinna, Kuithan, Friederike, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Herbst, Regina, Hänel, Mathias, Hanoun, Maher, Kaiser, Ulrich, Kaufmann, Martin, Rácil, Zdenek, Mayer, Jiri, Kroschinsky, Frank, Berdel, Wolfgang E., Ehninger, Gerhard, Serve, Hubert, Müller-Tidow, Carsten, Platzbecker, Uwe, Baldus, Claudia D., Schetelig, Johannes, Bornhäuser, Martin, Thiede, Christian, and Middeke, Jan Moritz

Published
2022
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37. Obinutuzumab, acalabrutinib, and venetoclax, after an optional debulking with bendamustine in relapsed or refractory chronic lymphocytic leukaemia (CLL2-BAAG): a multicentre, open-label, phase 2 trial

Author

Cramer, Paula, Fürstenau, Moritz, Robrecht, Sandra, Giza, Adam, Zhang, Can, Fink, Anna-Maria, Fischer, Kirsten, Langerbeins, Petra, Al-Sawaf, Othman, Tausch, Eugen, Schneider, Christof, Schetelig, Johannes, Dreger, Peter, Böttcher, Sebastian, Kreuzer, Karl-Anton, Schilhabel, Anke, Ritgen, Matthias, Brüggemann, Monika, Kneba, Michael, Stilgenbauer, Stephan, Eichhorst, Barbara, and Hallek, Michael

Published
2022
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38. Macroscopic, histologic, and clinical assessment of acute graft-versus-host disease of the upper gastrointestinal tract within 6 weeks after allogeneic hematopoietic cell transplantation

Author

Sarraf, Abed A., Schetelig, Johannes, Baldauf, Henning, Stölzel, Friedrich, Middeke, Jan Moritz, Sockel, Katja, Teipel, Raphael, Brückner, Stefan, Berning, Marco, Zeissig, Sebastian, Babatz, Jana, Baretton, Gustavo B., Hampe, Jochen, Bornhäuser, Martin, Aust, Daniela, and Schmelz, Renate

Published
2022
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39. Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study

Author

Middeke, Jan M., Metzeler, Klaus H., Röllig, Christoph, Krämer, Michael, Eckardt, Jan-Niklas, Stasik, Sebastian, Greif, Philipp A., Spiekermann, Karsten, Rothenberg-Thurley, Maja, Krug, Utz, Braess, Jan, Krämer, Alwin, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Görlich, Dennis, Sauerland, Cristina, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Kaufmann, Martin, Kunadt, Desiree, Wörmann, Bernhard, Sockel, Katja, von Bonin, Malte, Herold, Tobias, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Baldus, Claudia D., Ehninger, Gerhard, Schetelig, Johannes, Hiddemann, Wolfgang, Bornhäuser, Martin, Stölzel, Friedrich, and Thiede, Christian

Published
2022
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41. CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome

Author

Taube, Franziska, Georgi, Julia Annabell, Kramer, Michael, Stasik, Sebastian, Middeke, Jan Moritz, Röllig, Christoph, Krug, Utz, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Brümmendorf, Tim H., Naumann, Ralph, Petzold, Andreas, Mulet-Lazaro, Roger, Valk, Peter J.M., Steffen, Björn, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan W., Hänel, Mathias, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Herold, Sylvia, Stölzel, Friedrich, Sockel, Katja, von Bonin, Malte, Müller-Tidow, Carsten, Platzbecker, Uwe, Berdel, Wolfgang E., Serve, Hubert, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, and Thiede, Christian

Published
2022
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44. Autoreninnen und Autoren

Author

Ahrens, Marit, primary, Al-Batran, Salah-Eddin, additional, Armbrust, Robert, additional, Banek, Séverine, additional, Becker, Sven, additional, Bergmann, Lothar, additional, Bojunga, Jörg, additional, Brümmendorf, Tim Henrik, additional, Brunnberg, Uta, additional, Bug, Gesine, additional, Burger, Michael, additional, Chromik, Jörg, additional, Chun, Felix K.-H., additional, Czauderna, Carolin, additional, Dumoulin, Franz Ludwig, additional, Dreyling, Martin, additional, El-Balat, Ahmed, additional, Ellinger, Jörg, additional, Elsner, Susanne, additional, Enßle, Julius C., additional, Fottner, Christian, additional, Galle, Peter R., additional, Gökbuget, Nicola, additional, Götze, Thorsten Oliver, additional, Halbsguth, Teresa, additional, Höh, Benedikt, additional, Hohenberger, Peter, additional, Hübner, Joachim, additional, Hübner, Jutta, additional, Isfort, Susanne, additional, Kasper, Bernd, additional, Katalinic, Alexander, additional, Kestler, Angelika, additional, Khodamoradi, Yascha, additional, Kleemann, Johannes, additional, Kluth, Luis A., additional, Köhler, Viktoria F., additional, Kollmar, Otto, additional, Koschmieder, Steffen, additional, Lang, Fabian, additional, Makowka, Philipp, additional, Mallmann, Peter, additional, Mallmann-Gottschalk, Nina, additional, Mandel, Philipp, additional, Maurer, Gabriele, additional, Mayer, Arnulf, additional, Meissner, Markus, additional, Menge, Franka, additional, Middeke, Jan Moritz, additional, Miesbach, Wolfgang, additional, Möhler, Markus, additional, Möbus, Volker, additional, Müller, Stefan C., additional, Musholt, Thomas J., additional, Nauck, Friedemann, additional, Oellerich, Thomas, additional, Özistanbullu, Deniz, additional, Porschen, Rainer, additional, Pox, Christian, additional, Richter, Konrad Klaus, additional, Sauerbruch, Tilman, additional, Scheich, Sebastian, additional, Schetelig, . Johannes, additional, Schmidberger, Heinz, additional, Schnürch, Hans-Georg, additional, Sebastian, Martin, additional, Sehouli, Jalid, additional, Seifart, Ulf, additional, Serve, Hubert, additional, Seufferlein, Thomas, additional, Shaid, Shabnam, additional, Soysal, Savas D., additional, Steffen, Björn, additional, Steinbach, Joachim P., additional, Stratmann, Jan A., additional, Tsoukakis, Ioannis, additional, Ullrich, Evelyn, additional, Vehreschild, Janne, additional, Metzler, Ivana von, additional, Wolff, Michael von, additional, Voß, Martin, additional, Wagner, Sebastian, additional, Weber, Matthias M., additional, Wege, Henning, additional, Weis, Joachim, additional, Welte, Maria-Noemi, additional, Wenzel, Mike, additional, Wolf, Timo, additional, and Zurmeyer, David, additional

Published
2022
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45. Smart Conditioning with Venetoclax-Enhanced Sequential FLAMSA + RIC in Patients with High-Risk Myeloid Malignancies

Author

Schulz, Felicitas, primary, Jäger, Paul, additional, Tischer, Johanna, additional, Fraccaroli, Alessia, additional, Bug, Gesine, additional, Hausmann, Andreas, additional, Baermann, Ben-Niklas, additional, Tressin, Patrick, additional, Hoelscher, Alexander, additional, Kasprzak, Annika, additional, Nachtkamp, Kathrin, additional, Schetelig, Johannes, additional, Hilgendorf, Inken, additional, Germing, Ulrich, additional, Dietrich, Sascha, additional, and Kobbe, Guido, additional

Published
2024
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46. Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia

Author

Stasik, Sebastian, Eckardt, Jan-Niklas, Kramer, Michael, Röllig, Christoph, Krämer, Alwin, Scholl, Sebastian, Hochhaus, Andreas, Crysandt, Martina, Brümmendorf, Tim H., Naumann, Ralph, Steffen, Björn, Kunzmann, Volker, Einsele, Hermann, Schaich, Markus, Burchert, Andreas, Neubauer, Andreas, Schäfer-Eckart, Kerstin, Schliemann, Christoph, Krause, Stefan, Herbst, Regina, Hänel, Mathias, Frickhofen, Norbert, Noppeney, Richard, Kaiser, Ulrich, Baldus, Claudia D., Kaufmann, Martin, Rácil, Zdenek, Platzbecker, Uwe, Berdel, Wolfgang E., Mayer, Jiri, Serve, Hubert, Müller-Tidow, Carsten, Ehninger, Gerhard, Bornhäuser, Martin, Schetelig, Johannes, Middeke, Jan M., and Thiede, Christian

Published
2021
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47. Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial

Author

Al-Sawaf, Othman, primary, Ligtvoet, Rudy, additional, Robrecht, Sandra, additional, Stumpf, Janina, additional, Fink, Anna-Maria, additional, Tausch, Eugen, additional, Schneider, Christof, additional, Boettcher, Sebastian, additional, Mikusko, Martin, additional, Ritgen, Matthias, additional, Schetelig, Johannes, additional, von Tresckow, Julia, additional, Vehling-Kaiser, Ursula, additional, Gaska, Tobias, additional, Wendtner, Clemens Martin, additional, Chapuy, Bjoern, additional, Fischer, Kirsten, additional, Kreuzer, Karl-Anton, additional, Stilgenbauer, Stephan, additional, Staber, Philipp, additional, Niemann, Carsten, additional, Hallek, Michael, additional, and Eichhorst, Barbara, additional

Published
2023
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49. Mimicking Clinical Trials with Synthetic Acute Myeloid Leukemia Patients Using Generative Artificial Intelligence

Author

Eckardt, Jan-Niklas, primary, Hahn, Waldemar, additional, Roellig, Christoph, additional, Stasik, Sebastian, additional, Platzbecker, Uwe, additional, Mueller-Tidow, Carsten, additional, Serve, Hubert, additional, Baldus, Claudia D., additional, Schliemann, Christoph, additional, Schaefer-Eckart, Kerstin, additional, Hanoun, Maher, additional, Kaufmann, Martin, additional, Burchert, Andreas, additional, Thiede, Christian, additional, Schetelig, Johannes, additional, Sedlmayr, Martin, additional, Bornhaeuser, Martin, additional, Wolfien, Markus, additional, and Middeke, Jan Moritz, additional

Published
2023
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50. Supplementary Figures S1-S13 from Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells

Author

Nelde, Annika, primary, Schuster, Heiko, primary, Heitmann, Jonas S., primary, Bauer, Jens, primary, Maringer, Yacine, primary, Zwick, Melissa, primary, Volkmer, Jens-Peter, primary, Chen, James Y., primary, Stanger, Anna M. Paczulla, primary, Lehmann, Ariane, primary, Appiah, Bismark, primary, Märklin, Melanie, primary, Rücker-Braun, Elke, primary, Salih, Helmut R., primary, Roerden, Malte, primary, Schroeder, Sarah M., primary, Häring, Max-Felix, primary, Schlosser, Andreas, primary, Schetelig, Johannes, primary, Schmitz, Marc, primary, Boerries, Melanie, primary, Köhler, Natalie, primary, Lengerke, Claudia, primary, Majeti, Ravindra, primary, Weissman, Irving L., primary, Rammensee, Hans-Georg, primary, and Walz, Juliane S., primary

Published
2023
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