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10 results on '"Schetters, Sjoerd T.T."'

3. A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Author

Van Damme, Karel F.A., primary, Hoste, Levi, additional, Declercq, Jozefien, additional, Leeuw, Elisabeth De, additional, Maes, Bastiaan, additional, Martens, Liesbet, additional, Colman, Roos, additional, Browaeys, Robin, additional, Bosteels, Cédric, additional, Verwaerde, Stijn, additional, Vermeulen, Nicky, additional, Lameire, Sahine, additional, Debeuf, Nincy, additional, Deckers, Julie, additional, Stordeur, Patrick, additional, Guilliams, Martin, additional, Schetters, Sjoerd T.T., additional, Haerynck, Filomeen, additional, Tavernier, Simon J., additional, and Lambrecht, Bart N., additional

Published
2023
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4. Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition

Author

Stolk, Dorian A., primary, Horrevorts, Sophie K., additional, Schetters, Sjoerd T.T., additional, Kruijssen, Laura J.W., additional, Duinkerken, Sanne, additional, Keuning, Eelco, additional, Ambrosini, Martino, additional, Kalay, Hakan, additional, van de Ven, Rieneke, additional, Garcia-Vallejo, Juan J., additional, de Gruijl, Tanja D., additional, van Vliet, Sandra J., additional, and van Kooyk, Yvette, additional

Published
2021
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6. Single‐cell profiling of circulating and brain‐resident immune cells in a mouse model for amyloidosis and in aged mice

Author

van Olst, Lynn, primary, Verhoeff, Jan, additional, Schetters, Sjoerd T.T., additional, Hulshof, Lianne A., additional, van Dijk, Roland, additional, van der Pol, Susanne M.A., additional, Schouten, Marijn, additional, Vallejo, Juan J. Garcia, additional, van Der Flier, Wiesje, additional, Teunissen, Charlotte E., additional, Middeldorp, Jinte, additional, and de Vries, Helga E., additional

Published
2020
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7. Neuroinflammation: microglia and T cells get ready to tango

Author

Schetters, Sjoerd T.T., Gomez-Nicola, Diego, Garcia-Vallejo, Juan J., and Van Kooyk, Y.

Abstract

In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.

Published
2018

8. Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells

Author

Schetters, Sjoerd T.T., primary, Jong, Wouter S.P., additional, Horrevorts, Sophie K., additional, Kruijssen, Laura J.W., additional, Engels, Steef, additional, Stolk, Dorian, additional, Daleke-Schermerhorn, Maria H., additional, Garcia-Vallejo, Juan, additional, Houben, Diane, additional, Unger, Wendy W.J., additional, den Haan, Joke M.M., additional, Luirink, Joen, additional, and van Kooyk, Yvette, additional

Published
2019
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9. Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming

Author

van Dinther, Dieke, primary, Veninga, Henrike, additional, Iborra, Salvador, additional, Borg, Ellen G.F., additional, Hoogterp, Leoni, additional, Olesek, Katarzyna, additional, Beijer, Marieke R., additional, Schetters, Sjoerd T.T., additional, Kalay, Hakan, additional, Garcia-Vallejo, Juan J., additional, Franken, Kees L., additional, Cham, Lamin B., additional, Lang, Karl S., additional, van Kooyk, Yvette, additional, Sancho, David, additional, Crocker, Paul R., additional, and den Haan, Joke M.M., additional

Published
2018
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10. Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+T Cell Cross-Priming

Author

van Dinther, Dieke, Veninga, Henrike, Iborra, Salvador, Borg, Ellen G.F., Hoogterp, Leoni, Olesek, Katarzyna, Beijer, Marieke R., Schetters, Sjoerd T.T., Kalay, Hakan, Garcia-Vallejo, Juan J., Franken, Kees L., Cham, Lamin B., Lang, Karl S., van Kooyk, Yvette, Sancho, David, Crocker, Paul R., and den Haan, Joke M.M.

Abstract

Splenic CD169+macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8+T cell responses by antigens (Ags) bound by CD169+macrophages. Upon Ag targeting to CD169+macrophages, we show that BATF3-dependent CD8α+dendritic cells (DCs) are crucial for DNGR-1-mediated cross-priming of CD8+T cell responses. In addition, we demonstrate that CD169, a sialic acid binding lectin involved in cell-cell contact, preferentially binds to CD8α+DCs and that Ag transfer to CD8α+DCs and subsequent T cell activation is dependent on the sialic acid-binding capacity of CD169. Finally, functional CD169 mediates optimal CD8+T cell responses to modified vaccinia Ankara virus infection. Together, these data indicate that the collaboration of CD169+macrophages and CD8α+DCs for the initiation of effective CD8+T cell responses is facilitated by binding of CD169 to sialic acid containing ligands on CD8α+DCs.

Published
2018
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