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Background: There are approximately 1,000,000 pregnant women at high risk for obstetric complications per year, more than half of whom require hospitalization., Objective: The aim of this study was to determine the relation between online health information seeking and anxiety levels in a sample of hospitalized woman with pregnancy-related complications., Methods: A sample of 105 pregnant women hospitalized in northern Italy, all with an obstetric complication diagnosis, completed different questionnaires: Use of Internet Health-information (UIH) questionnaire about use of the internet, EuroQOL 5 dimensions (EQ-5D) questionnaire on quality of life, State-Trait Anxiety Inventory (STAI) questionnaire measuring general anxiety levels, and a questionnaire about critical events occurring during hospitalization., Results: Overall, 98/105 (93.3%) of the women used the internet at home to obtain nonspecific information about health in general and 95/105 (90.5%) of the women used the internet to specifically search for information related to their obstetric disease. Online health information-seeking behavior substantially decreased the self-reported anxiety levels (P=.008)., Conclusions: Web browsing for health information was associated with anxiety reduction, suggesting that the internet can be a useful instrument in supporting professional intervention to control and possibly reduce discomfort and anxiety for women during complicated pregnancies., (©Fabiana Coglianese, Giulia Beltrame Vriz, Nicola Soriani, Gianluca Niccolò Piras, Rosanna Irene Comoretto, Laura Clemente, Jessica Fasan, Lucia Cristiano, Valentina Schiavinato, Valter Adamo, Diego Marchesoni, Dario Gregori. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 06.05.2020.)