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3. PREVALENCE OF LYMPHEDEMA USING LARGE DATA SETS; AN EPIDEMIOLOGICAL ANALYSIS IN THE UNITED STATES AND IN ITALY.

Author

Grigorean, A., Voci, D., Farmakis, I. T., Hobohm, L., Keller, K., Kucher, N., Luchsinger, I., Micieli, E., Schievano, E., Barco, S., and Fedeli, U.

Subjects
EPIDEMIOLOGY, BIG data, SKIN infections, THROMBOEMBOLISM, LYMPHEDEMA
Abstract

There is a lack of large epidemiological studies focusing on the prevalence of lymphedema. Vital registration data from the United States (US) (1999-2020) and Veneto, Italy (2008-2021) were analyzed. Lymphedema-related deaths were identified using disease-specific ICD-10 codes and served to estimate the burden of disease in the general population. We studied (i) the lymphedema-specific proportionate mortality as a proxy of the disease-specific prevalence, (ii) the prevalence of lymphedema in key patient subgroups, and (iii) age and sex-specific mortality rates. The prevalence of lymphedema increased over the last two decades with marked sex-specific differences: in the US, the estimated prevalence of lymphedema was 2.7 per 10,000 deaths for women and 1.5 per 10,000 deaths for men. In Veneto, the prevalence was 3.0 per 10,000 deaths for women and 1.1 per 10,000 deaths for men. The prevalence of lymphedema was 2- to 20-times in specific subgroups of patients, including those with obesity, skin infections, hypertension, diabetes mellitus, breast/gynecological cancers, and venous thromboembolism. The estimated prevalence of lymphedema is 2- to 3-times higher than previously thought and has been increasing for the past two decades. These results will serve as a reference for future research in this field. [ABSTRACT FROM AUTHOR]

Published
2023

5. A Contribution to the Harmonization of Non-targeted NMR Methods for Data-Driven Food Authenticity Assessment

Author

Gallo, V, Ragone, R, Musio, B, Todisco, S, Rizzuti, A, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Pascazio, A, Cobas, C, Mari, S, Garino, C, Arlorio, M, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Barison, A, Benevelli, F, Borioni, A, Cagliani, L, Casadei, L, Marincola, F, Colson, K, Consonni, R, Costantino, G, Cremonini, M, Davalli, S, Duarte, I, Guyader, S, Hamon, E, Hegmanns, M, Lamanna, R, Longobardi, F, Mallamace, D, Mammi, S, Markus, M, Menezes, L, Milone, S, Molero-Vilchez, D, Mucci, A, Napoli, C, Rossi, M, Saez-Barajas, E, Savorani, F, Schievano, E, Sciubba, F, Sobolev, A, Takis, P, Thomas, F, Villa-Valverde, P, Latronico, M, Gallo V., Ragone R., Musio B., Todisco S., Rizzuti A., Mastrorilli P., Pontrelli S., Intini N., Scapicchio P., Triggiani M., Pascazio A., Cobas C., Mari S., Garino C., Arlorio M., Acquotti D., Airoldi C., Arnesano F., Assfalg M., Barison A., Benevelli F., Borioni A., Cagliani L. R., Casadei L., Marincola F. C., Colson K., Consonni R., Costantino G., Cremonini M. A., Davalli S., Duarte I., Guyader S., Hamon E., Hegmanns M., Lamanna R., Longobardi F., Mallamace D., Mammi S., Markus M., Menezes L. R. A., Milone S., Molero-Vilchez D., Mucci A., Napoli C., Rossi M. C., Saez-Barajas E., Savorani F., Schievano E., Sciubba F., Sobolev A., Takis P. G., Thomas F., Villa-Valverde P., Latronico M., Gallo, V, Ragone, R, Musio, B, Todisco, S, Rizzuti, A, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Pascazio, A, Cobas, C, Mari, S, Garino, C, Arlorio, M, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Barison, A, Benevelli, F, Borioni, A, Cagliani, L, Casadei, L, Marincola, F, Colson, K, Consonni, R, Costantino, G, Cremonini, M, Davalli, S, Duarte, I, Guyader, S, Hamon, E, Hegmanns, M, Lamanna, R, Longobardi, F, Mallamace, D, Mammi, S, Markus, M, Menezes, L, Milone, S, Molero-Vilchez, D, Mucci, A, Napoli, C, Rossi, M, Saez-Barajas, E, Savorani, F, Schievano, E, Sciubba, F, Sobolev, A, Takis, P, Thomas, F, Villa-Valverde, P, Latronico, M, Gallo V., Ragone R., Musio B., Todisco S., Rizzuti A., Mastrorilli P., Pontrelli S., Intini N., Scapicchio P., Triggiani M., Pascazio A., Cobas C., Mari S., Garino C., Arlorio M., Acquotti D., Airoldi C., Arnesano F., Assfalg M., Barison A., Benevelli F., Borioni A., Cagliani L. R., Casadei L., Marincola F. C., Colson K., Consonni R., Costantino G., Cremonini M. A., Davalli S., Duarte I., Guyader S., Hamon E., Hegmanns M., Lamanna R., Longobardi F., Mallamace D., Mammi S., Markus M., Menezes L. R. A., Milone S., Molero-Vilchez D., Mucci A., Napoli C., Rossi M. C., Saez-Barajas E., Savorani F., Schievano E., Sciubba F., Sobolev A., Takis P. G., Thomas F., Villa-Valverde P., and Latronico M.

Abstract

Spectroscopic non-targeted methods are gaining ever-growing importance in quality control and authenticity assessment of food products because of their strong potential for identification of specific features of the products by data-driven classifiers. One of the factors hampering the diffusion of spectroscopic non-targeted methods and data-driven classifiers is the lack of harmonized guidelines for their development and validation. In particular, to date, neither conditions to directly compare spectra recorded by different spectrometers nor studies demonstrating the statistical equivalence of the spectra are available. Among the spectroscopic analytical techniques suitable for the development of non-targeted methods, nuclear magnetic resonance (NMR) offers the unique opportunity to generate statistically equivalent signals. In this paper, the feasibility of NMR spectroscopy to generate statistically equivalent NMR signals from a number of different spectrometers was demonstrated for complex mixtures (aqueous extracts of wheat and flour) by organizing an inter-laboratory comparison involving 36 NMR spectrometers. Univariate statistics along with multivariate analysis were exploited to establish unbiased criteria for assessing the statistical equivalence of the NMR signals. The aspects affecting the signal equivalence were investigated, and possible solutions to reduce the extent of the human error were proposed and applied with satisfactory results. This study furnishes the scientific community with an appropriate and easy procedure to validate non-targeted NMR methods and provides error values to be used as a reference for future studies.

Published
2020

6. Splanchnic vein thrombosis-related mortality in the Veneto region (Italy), 2008-2019: Retrospective analysis of epidemiological data

Author

Turatti, G., Fedeli, U., Valerio, L., Klok, F.A., Cohen, A.T., Hunt, B.J., Simioni, P., Middeldorp, S., Ageno, W., Kucher, N., Konstantinides, S.V., Schievano, E., Barco, S., Turatti, G., Fedeli, U., Valerio, L., Klok, F.A., Cohen, A.T., Hunt, B.J., Simioni, P., Middeldorp, S., Ageno, W., Kucher, N., Konstantinides, S.V., Schievano, E., and Barco, S.

Abstract

Item does not contain fulltext, BACKGROUND: Splanchnic vein thrombosis (SVT) is an uncommon manifestation of venous thromboembolism. Epidemiological data on SVT-related mortality rate is not available to date. METHODS: We investigated time trends in SVT-related mortality rate, 2008-2019, in Veneto, an Italian high-income region of approximatively 5,000,000 inhabitants. SVT-related deaths were identified by the following ICD-10 codes: I81 (portal vein thrombosis), K75.1 (phlebitis of portal vein), K76.3 (liver infarction), K76.5 (hepatic veno-occlusive disease) or I82.0 (Budd-Chiari syndrome). RESULTS: During the study period, a total of 557,932 deaths were recorded. SVT was reported in 823 cases; 776 (94%) consisted of portal vein thrombosis. The age-standardized SVT-related mortality rate varied from 1.47 (year 2008) to 1.52 (year 2019) per 100,000 person-years. An increase in the cause-specific annual mortality rate was observed in women (0.56 in 2008 to 1.04 per 100,000 person-years in 2019; average annual percent change +5.7%, 95%CI +3.1; +8.3%). In men, the cause-specific mortality rate moved from 2.53 in 2008 to 2.03 per 100,000 person-years in 2019 (average annual percent change -1.2%, 95%CI -4.0; +1.6%). After conditioning for age and sex, the odds of having a concomitant liver disease were higher for SVT-related deaths (OR 31.6; 95%CI 17.1-37.0) compared with non-SVT-related deaths. This also applies to gastrointestinal cancers (OR 1.28; 95%CI 1.07-1.55), although to a lesser extent. CONCLUSIONS: We report first epidemiological estimates of SVT-related mortality in a Western country. These values will serve as a reference to weight novel potential factors associated with SVT-related death and interpret them from an epidemiological perspective.

Published
2022

7. Congestive heart failure and comorbidity as determinants of colorectal cancer perioperative outcomes

Author

Basso, C., Gennaro, N., Dotto, M., Ferroni, E., Noale, M., Avossa, F., Schievano, E., Aceto, Paola, Tommasino, C., Crucitti, Antonio, Incalzi, R. A., Volpato, S., Petrini, F., Carron, M., Pace, M. C., Bettelli, G., Chiumiento, F., Corcione, A., Montorsi, M., Trabucchi, Marta, Maggi, S., Corti, M. C., Aceto P. (ORCID:0000-0002-0228-0603), Crucitti A. (ORCID:0000-0003-3496-4185), Trabucchi M., Basso, C., Gennaro, N., Dotto, M., Ferroni, E., Noale, M., Avossa, F., Schievano, E., Aceto, Paola, Tommasino, C., Crucitti, Antonio, Incalzi, R. A., Volpato, S., Petrini, F., Carron, M., Pace, M. C., Bettelli, G., Chiumiento, F., Corcione, A., Montorsi, M., Trabucchi, Marta, Maggi, S., Corti, M. C., Aceto P. (ORCID:0000-0002-0228-0603), Crucitti A. (ORCID:0000-0003-3496-4185), and Trabucchi M.

Abstract

There has been an increase in surgical interventions in frailer elderly with concomitant chronic diseases. The purpose of this paper was to evaluate the impact of aging and comorbidities on outcomes in patients who underwent surgery for the treatment of colorectal cancer (CRC) in Veneto Region (Northeastern Italy). This is a retrospective cohort study in patients ≥ 40 years who underwent elective or urgent CRC surgical resection between January 2013 and December 2015. Independent variables included: age, sex, and comorbidities. We analyzed variables associated with the surgical procedure, such as stoma creation, hospitalization during the year before the index surgery, the surgical approach used, the American Society of Anesthesiologists (ASA) score, and the Charlson Comorbidity Index score. Eight thousand four hundred and forty-seven patients with CRC underwent surgical resection. Patient age affected both pre- and post-resection LOS as well as the overall survival (OS); however, it did not affect the 30-day readmission and reoperation rates. Multivariate analysis showed that age represented a risk factor for longer preoperative and postoperative LOS as well as for 30-day and 365-day mortality, but it was not associated with an increased risk of 30-day reoperation and 30-day readmission. Chronic Heart Failure increased the 30-day mortality risk by four times, the preoperative LOS by 51%, and the postoperative LOS by 33%. Chronic renal failure was associated with a 74% higher 30-day readmission rate. Advanced age and comorbidities require a careful preoperative evaluation and appropriate perioperative management to improve surgical outcomes in older patients undergoing elective or urgent CRC resection.

Published
2022

8. Different approaches to the analysis of causes of death during the COVID-19 epidemic

Author

Fedeli, U, Schievano, E, Avossa, F, Pitter, G, Barbiellini Amidei, C, Grande, E, and Grippo, F

Subjects
Multiple causes of death, Italy, COVID-19, Mortality, Cause of Death, Diabetes Mellitus, Humans, Pneumonia, Epidemics, Death Certificates
Abstract

The aim of the study is to assess the impact of the COVID-19 pandemic on causes of mortality through multiple methodological approaches.The causes of mortality in the Veneto region (Italy) during the first epidemic wave, March-April 2020, were compared with the corresponding months of the previous two years. Both the underlying cause of death (UCOD), and all diseases reported in the death certificate (multiple causes of death) were investigated; a further analysis was carried out through a simulation where the UCOD was selected after substituting ICD-10 codes for COVID with unspecified pneumonia.Overall 10,222 deaths were registered in March-April 2020, corresponding to a 24% increase compared to the previous two years. COVID-19 was mentioned in 1,444 certificates, and selected as the UCOD in 1,207 deaths. Based on the UCOD, the increases in mortality were observed for COVID and related respiratory conditions, diabetes mellitus, hypertensive heart diseases, cerebrovascular diseases, and ill-defined causes. Multiple causes of death and the simulation analysis demonstrated further increases in mortality related to dementia/Alzheimer and chronic lower respiratory diseases.This first report demonstrates an increase of several causes of death during the pandemic, underlying the need of a continuous surveillance of mortality records through different analytic strategies.

Published
2021

13. A community-built calibration system: The case study of quantification of metabolites in grape juice by qNMR spectroscopy

Author

Musio, B, Ragone, R, Todisco, S, Rizzuti, A, Latronico, M, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Di Noia, T, Acquotti, D, Airoldi, C, Assfalg, M, Barge, A, Bateman, L, Benevelli, F, Bertelli, D, Bertocchi, F, Bieliauskas, A, Borioni, A, Caligiani, A, Callone, E, Čamra, A, Cesare Marincola, F, Chalasani, D, Consonni, R, Dambruoso, P, Davalli, S, David, T, Diehl, B, Donarski, J, Gil, A, Gobetto, R, Goldoni, L, Hamon, E, Harwood, J, Kobrlová, A, Longobardi, F, Luisi, R, Mallamace, D, Mammi, S, Martin-Biran, M, Mazzei, P, Mele, A, Milone, S, Molero Vilchez, D, Mulder, R, Napoli, C, Ragno, D, Randazzo, A, Rossi, M, Rotondo, A, Šačkus, A, Sáez Barajas, E, Schievano, E, Sitaram, B, Stevanato, L, Takis, P, Teipel, J, Thomas, F, Torregiani, E, Valensin, D, Veronesi, M, Warren, J, Wist, J, Zailer-Hafer, E, Zuccaccia, C, Gallo, V, Musio, Biagia, Ragone, Rosa, Todisco, Stefano, Rizzuti, Antonino, Latronico, Mario, Mastrorilli, Piero, Pontrelli, Stefania, Intini, Nicola, Scapicchio, Pasquale, Triggiani, Maurizio, Di Noia, Tommaso, Acquotti, Domenico, Airoldi, Cristina, Assfalg, Michael, Barge, Alessandro, Bateman, Lorraine, Benevelli, Francesca, Bertelli, Davide, Bertocchi, Fabio, Bieliauskas, Aurimas, Borioni, Anna, Caligiani, Augusta, Callone, Emanuela, Čamra, Ales, Cesare Marincola, Flaminia, Chalasani, Dinesh, Consonni, Roberto, Dambruoso, Paolo, Davalli, Silvia, David, Taylor, Diehl, Bernd, Donarski, James, Gil, Ana M., Gobetto, Roberto, Goldoni, Luca, Hamon, Erwann, Harwood, John S., Kobrlová, Andrea, Longobardi, Francesco, Luisi, Renzo, Mallamace, Domenico, Mammi, Stefano, Martin-Biran, Magali, Mazzei, Pierluigi, Mele, Andrea, Milone, Salvatore, Molero Vilchez, Dolores, Mulder, Roger J., Napoli, Claudia, Ragno, Daniele, Randazzo, Antonio, Rossi, Maria Cecilia, Rotondo, Archimede, Šačkus, Algirdas, Sáez Barajas, Elena, Schievano, Elisabetta, Sitaram, Bhavaraju, Stevanato, Livio, Takis, Panteleimon G., Teipel, Jan, Thomas, Freddy, Torregiani, Elisabetta, Valensin, Daniela, Veronesi, Marina, Warren, John, Wist, Julien, Zailer-Hafer, Elina, Zuccaccia, Cristiano, Gallo, Vito, Musio, B, Ragone, R, Todisco, S, Rizzuti, A, Latronico, M, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Di Noia, T, Acquotti, D, Airoldi, C, Assfalg, M, Barge, A, Bateman, L, Benevelli, F, Bertelli, D, Bertocchi, F, Bieliauskas, A, Borioni, A, Caligiani, A, Callone, E, Čamra, A, Cesare Marincola, F, Chalasani, D, Consonni, R, Dambruoso, P, Davalli, S, David, T, Diehl, B, Donarski, J, Gil, A, Gobetto, R, Goldoni, L, Hamon, E, Harwood, J, Kobrlová, A, Longobardi, F, Luisi, R, Mallamace, D, Mammi, S, Martin-Biran, M, Mazzei, P, Mele, A, Milone, S, Molero Vilchez, D, Mulder, R, Napoli, C, Ragno, D, Randazzo, A, Rossi, M, Rotondo, A, Šačkus, A, Sáez Barajas, E, Schievano, E, Sitaram, B, Stevanato, L, Takis, P, Teipel, J, Thomas, F, Torregiani, E, Valensin, D, Veronesi, M, Warren, J, Wist, J, Zailer-Hafer, E, Zuccaccia, C, Gallo, V, Musio, Biagia, Ragone, Rosa, Todisco, Stefano, Rizzuti, Antonino, Latronico, Mario, Mastrorilli, Piero, Pontrelli, Stefania, Intini, Nicola, Scapicchio, Pasquale, Triggiani, Maurizio, Di Noia, Tommaso, Acquotti, Domenico, Airoldi, Cristina, Assfalg, Michael, Barge, Alessandro, Bateman, Lorraine, Benevelli, Francesca, Bertelli, Davide, Bertocchi, Fabio, Bieliauskas, Aurimas, Borioni, Anna, Caligiani, Augusta, Callone, Emanuela, Čamra, Ales, Cesare Marincola, Flaminia, Chalasani, Dinesh, Consonni, Roberto, Dambruoso, Paolo, Davalli, Silvia, David, Taylor, Diehl, Bernd, Donarski, James, Gil, Ana M., Gobetto, Roberto, Goldoni, Luca, Hamon, Erwann, Harwood, John S., Kobrlová, Andrea, Longobardi, Francesco, Luisi, Renzo, Mallamace, Domenico, Mammi, Stefano, Martin-Biran, Magali, Mazzei, Pierluigi, Mele, Andrea, Milone, Salvatore, Molero Vilchez, Dolores, Mulder, Roger J., Napoli, Claudia, Ragno, Daniele, Randazzo, Antonio, Rossi, Maria Cecilia, Rotondo, Archimede, Šačkus, Algirdas, Sáez Barajas, Elena, Schievano, Elisabetta, Sitaram, Bhavaraju, Stevanato, Livio, Takis, Panteleimon G., Teipel, Jan, Thomas, Freddy, Torregiani, Elisabetta, Valensin, Daniela, Veronesi, Marina, Warren, John, Wist, Julien, Zailer-Hafer, Elina, Zuccaccia, Cristiano, and Gallo, Vito

Abstract

Nuclear Magnetic Resonance (NMR) is an analytical technique extensively used in almost every chemical laboratory for structural identification. This technique provides statistically equivalent signals in spite of using spectrometer with different hardware features and is successfully used for the traceability and quantification of analytes in food samples. Nevertheless, to date only a few internationally agreed guidelines have been reported on the use of NMR for quantitative analysis. The main goal of the present study is to provide a methodological pipeline to assess the reproducibility of NMR data produced for a given matrix by spectrometers from different manufacturers, with different magnetic field strengths, age and hardware configurations. The results have been analyzed through a sequence of chemometric tests to generate a community-built calibration system which was used to verify the performance of the spectrometers and the reproducibility of the predicted sample concentrations.

Published
2020

14. Structure-function studies of analogues of parathyroid hormone (PTH)-1-34 containing beta-amino acid residues in positions 11-13

Author

Peggion, E., Mammi, S., Schievano, E., Silvestri, L., Schiebler, L., Bisello, A., Rosenblatt, M., and Chorev, M.

Subjects
Parathyroid hormone -- Analysis, Structure-activity relationships (Biochemistry) -- Analysis, Amino acids -- Structure-activity relationships, Conformational analysis -- Research, Biological sciences, Chemistry
Abstract

Research demonstrates that analogues of human parathyroid hormone-1-34, each containing an insertion of a single beta-amino acid residue in positions 11,12, or 13, does not exhibit any structural disorder in this particular portion of the sequence of the hormone.

Published
2002

15. Aib-rich peptides containing lactam-bridged side chains as models of the 310-Helix

Author

Schievano, E, Bisello, A, Chorev, M, Bisol, A, Mammi, S, and Peggion, E

Subjects
Chemistry, Physical and theoretical -- Research, Peptides -- Research, Chemistry
Abstract

Chemistry research is presented describing the study of helix models to determine the side chains of lactam-bridged aib-rich peptide compounds.

Published
2001

18. Estimating the real burden of cardiovascular mortality in diabetes

Author

Fedeli, Ugo, Schievano, E, Targher, G, Bonora, E, Corti, M C, and Zoppini, G

Subjects
Adult, Aged, 80 and over, Male, diabetes, cardiovascular mortality, Age Factors, Middle Aged, Diabetes Complications, Cost of Illness, Italy, Cardiovascular Diseases, Cause of Death, Humans, Female, Aged, Follow-Up Studies
Abstract

To compare different methods assessing the burden of cardiovascular mortality in diabetes mellitus, which is usually underestimated by standard mortality statistics based on the underlying cause of death.All residents in the Veneto Region (Italy) aged 30-89 years with co-payment exemption for diabetes in January 2010 (n=185,341) were identified and linked with mortality records (2010-2015). The underlying causes of death, as well as all the diseases mentioned in the death certificate (multiple causes), were extracted. The standardized mortality ratios (SMR) were computed with regional rates as a reference.After grouping diabetes and circulatory diseases as the underlying cause of death, the mortality rates were highly increased, especially among patients aged 30-54 years: SMR 4.24 (95% confidence interval 3.57-5.00) and 9.84 (7.47-12.72) in males and females, respectively. After re-assignment of the underlying cause in deaths from diabetes, the percentage of overall mortality caused by circulatory diseases increased from 33.8% to 41.7%. Based on multiple causes, the risk of death was increased for several cardiovascular diseases, including causes rarely emerging from standard mortality statistics such as atrial fibrillation/flutter.The re-assignment of the underlying cause and the analyses of the multiple causes of death allowed to estimate the whole burden of mortality associated with cardiovascular diseases.

Published
2019

20. Impactibility Model for Population Health Management in High-Cost Elderly Heart Failure Patients: A Capture Method Using the ACG System

Author

Buja, A, Rivera, M, Soattin, M, Corti, Mc, Avossa, F, Schievano, E, Rigon, S, Baldo, V, Boccuzzo, G, Damiani, Gianfranco, Ebell, Mh, Damiani G (ORCID:0000-0003-3028-6188), Buja, A, Rivera, M, Soattin, M, Corti, Mc, Avossa, F, Schievano, E, Rigon, S, Baldo, V, Boccuzzo, G, Damiani, Gianfranco, Ebell, Mh, and Damiani G (ORCID:0000-0003-3028-6188)

Abstract

The aim of the present study is to use the ACG (Adjusted Clinical Groups) System to create an impactibility model by identifying homogeneous clinical subgroups of patients with high risk of an adverse health outcome in a population of heart failure patients with complex health care needs (PCHCN). This method will allow policy makers to target and prioritize services for the highest risk PCHCN in the context of limited health care resources, by identifying relatively homogeneous groups of patients with similar comorbidities. Subjects classified in 2012 as PCHCN in a local health unit by the ACG System were linked with hospital discharge records in 2013. The authors applied the Apriori algorithm to identify the most common sets of the most predictive diseases for the following outcomes of interest: at least 1 admission and at least 1 preventable admission in the year. Predictive performance for the former outcome was compared between the impactability model with the available ACG's individual risk score. The Apriori algorithm also was applied to predict the latter outcome as an example of an event that a policy maker would be able to prevent. Evidence showed no statistically significant difference between the 2 methods. The present model also displayed evidence of good calibration. The Apriori algorithm was applied as an impactibility model, built based on the ACG System, that allowed the authors to obtain an "ACG-based group risk score" and use it to identify clinically homogeneous subgroups of PCHCN. This will help policy makers develop "tool kits" for homogeneous groups of patients that improve health outcomes.

Published
2019

28. Performance Assessment in Fingerprinting and Multi Component Quantitative NMR Analyses

Author

Gallo, V, Intini, N, Mastrorilli, P, Latronico, M, Scapicchio, P, Triggiani, M, Bevilacqua, V, Fanizzi, P, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Benevelli, F, Bertelli, D, Cagliani, L, Casadei, L, Cesare Marincola, F, Colafemmina, G, Consonni, R, Cosentino, C, Davalli, S, De Pascali, S, D'Aiuto, V, Faccini, A, Gobetto, R, Lamanna, R, Liguori, F, Longobardi, F, Mallamace, D, Mazzei, P, Menegazzo, I, Milone, S, Mucci, A, Napoli, C, Pertinhez, T, Rizzuti, A, Rocchigiani, L, Schievano, E, Sciubba, F, Sobolev, A, Tenori, L, Valerio, M, Gallo, V, Intini, N, Mastrorilli, P, Latronico, M, Scapicchio, P, Triggiani, M, Bevilacqua, V, Fanizzi, P, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Benevelli, F, Bertelli, D, Cagliani, L, Casadei, L, Cesare Marincola, F, Colafemmina, G, Consonni, R, Cosentino, C, Davalli, S, De Pascali, S, D'Aiuto, V, Faccini, A, Gobetto, R, Lamanna, R, Liguori, F, Longobardi, F, Mallamace, D, Mazzei, P, Menegazzo, I, Milone, S, Mucci, A, Napoli, C, Pertinhez, T, Rizzuti, A, Rocchigiani, L, Schievano, E, Sciubba, F, Sobolev, A, Tenori, L, and Valerio, M

Abstract

An interlaboratory comparison (ILC) was organized with the aim to set up quality control indicators suitable for multicomponent quantitative analysis by nuclear magnetic resonance (NMR) spectroscopy. A total of 36 NMR data sets (corresponding to 1260 NMR spectra) were produced by 30 participants using 34 NMR spectrometers. The calibration line method was chosen for the quantification of a five-component model mixture. Results show that quantitative NMR is a robust quantification tool and that 26 out of 36 data sets resulted in statistically equivalent calibration lines for all considered NMR signals. The performance of each laboratory was assessed by means of a new performance index (named Qp-score) which is related to the difference between the experimental and the consensus values of the slope of the calibration lines. Laboratories endowed with a Qp-score falling within the suitable acceptability range are qualified to produce NMR spectra that can be considered statistically equivalent in terms of relative intensities of the signals. In addition, the specific response of nuclei to the experimental excitation/relaxation conditions was addressed by means of the parameter named NR. NR is related to the difference between the theoretical and the consensus slopes of the calibration lines and is specific for each signal produced by a well-defined set of acquisition parameters. (Graph Presented).

Published
2015

34. Monitoring the occurrence of diabetes mellitus and its major complications: the combined use of different administrative databases

Author

Brocco, S, Visentin, C, Fedeli, U, Schievano, E, Avogaro, Angelo, Andretta, M, Avossa, F, and Spolaore, P.

Subjects
Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Databases, Factual, Incidence, Survival Analysis, Medical Records, Diabetes Complications, Hospitalization, Italy, lcsh:RC666-701, Diabetes Mellitus, Prevalence, Humans, Diabetic Nephropathies, Female, Diabetic Angiopathies, Original Investigation
Abstract

Objective Diabetes mellitus is a growing public health problem, for which efficient and timely surveillance is a key policy. Administrative databases offer relevant opportunities for this purpose. We aim to monitor the incidence of diabetes and its major complications using administrative data. Study design and methods We study a population of about 850000 inhabitants in the Veneto Region (Italy) from the end of year 2001 to the end of year 2004. We use four administrative databases with record linkage. Databases of drug prescriptions and of exemptions from medical charge were linked to identify diabetic subjects; hospital discharge records and mortality data were used for the assessment of macrovascular and renal complications and vital status. Results We identified 30230 and 34620 diabetic subjects at the start and at the end of the study respectively. The row prevalence increased from 38.3/1000 (95% CI 37.2 – 39.5) to 43.2/1000 (95% CI 42.3 – 44) for males and from 34.7/1000 (95% CI 33.9 – 35.5) to 38.1/1000 (95% CI 37.4 – 39) for females. The mean row incidence is 5.3/1000 (95% CI 5 – 5.6) person years for males and 4.8/1000 (95% CI 4.4 – 5.2) person years for females. The rate of hospitalisations for cardiovascular or kidney diseases is greatly increased in diabetic people with respect to non diabetics for both genders. The mortality relative risk is particularly important in younger age classes: diabetic males and females aged 45–64 years present relative risk for death of 1.7 (95% CI 1.58 – 1.88) and 2.6 (95% CI 2.29 – 2.97) respectively. Conclusion This study provides a feasible and efficient method to determine and monitor the incidence and prevalence of diabetes and the occurrence of its complications along with indexes of morbidity and mortality.

Published
2007

36. Garda PDO olive oil: NMR and multivariate statistical analysis

Author

Schievano E, Arosio I, Lava R, Simionato V, Mammi S, and Consonni R

Subjects
PCA, PDO, extra virgin olive oil, NMR
Abstract

Extra virgin olive oils from Garda lake were analysed by means of high resolution H-1 NMR spectroscopy in combination with statistical methods. Selected resonances from acquired spectra were quantified and submitted to PCA analysis (Principal Component Analysis) giving rise to a clear grouping according to their geographical origin, i.e., the Veneto and Lombardia banks of Garda take. Our results indicate the possibility to distinguish extra virgin olive oils of the same Protected Denomination of Origin area - Garda lake - with respect to different microareas.

Published
2006

41. Interaction of Bombolitin II with a Membrane-Mimetic Environment: an NMR and Molecular Dynamics Simulation Approach

Author

Monticelli L., Pedini D., Schievano E., Mammi S., and Peggion E.

Abstract

Bombolitins are five natural heptadecapeptides originally isolated from the venom of a bumblebee. They induce lysis of erythrocytes and liposomes and increase the activity of phospholipase A2 (PLA2), that plays an important role in the early steps of the inflammatory process. It has been proposed that PLA2 activation depends on the alteration of the physical state of the membrane. Bombolitin II folds into an alpha-helix in a membrane mimicking environment constituted by SDS micelles [Battistutta et al., Macromol. Chem. Phys., 196 (1995) 2827-2841]. In the present work, the topological orientation of the peptide relative to the micelle was determined, using three spin probes localized in different positions of the water/micelle system. The reduction in intensity of the 1H NMR signals clearly demonstrated that the peptide is located on the surface of the micelle, with its helical axis parallel to the interface. Only a small portion of the helix is exposed to the aqueous environment. Results from NMR experiments were confirmed by molecular dynamics simulations, performed using a two-phase water/decane simulation cell. The timescale for the reorientation of the peptide was between 120 and 450 ps, depending on the starting position of the peptide.

Published
2002

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