17 results on '"Schijns, O. E. M. G."'
Search Results
2. Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature
- Author
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Slegers, R. J., Bouwens van der Vlis, T. A. M., Ackermans, L., Hoeben, A., Postma, A. A., Compter, I., Hoeijmakers, J. G. J., Beckervordersandforth, J., Broen, M. P. G., and Schijns, O. E. M. G.
- Published
- 2022
- Full Text
- View/download PDF
3. Patient-derived Glioblastoma Organoids reflect tumor heterogeneity and treatment sensitivity
- Author
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Verduin, M, primary, Hoosemans, L, additional, Vanmechelen, M, additional, van Heumen, M, additional, Piepers, J A F, additional, Astuti, G, additional, Ackermans, L, additional, Schijns, O E M G, additional, Kampen, K R, additional, Tjan-Heijnen, V C G, additional, de Barbanson, B A, additional, Postma, A A, additional, Eekers, D B P, additional, Broen, M P G, additional, Beckervordersandforth, J, additional, Staňková, K, additional, De Smet, F, additional, Rich, J, additional, Hubert, C G, additional, Gimenez, G, additional, Chatterjee, A, additional, Hoeben, A, additional, and Vooijs, M A, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Visual field deficits after epilepsy surgery: a new quantitative scoring method
- Author
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van Lanen, Rick H. G. J., Hoeberigs, M. C., Bauer, N. J. C., Haeren, R. H. L., Hoogland, G., Colon, A., Piersma, C., Dings, J. T. A., and Schijns, O. E. M. G.
- Published
- 2018
- Full Text
- View/download PDF
5. Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature
- Author
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Slegers, R. J., primary, Bouwens van der Vlis, T. A. M., additional, Ackermans, L., additional, Hoeben, A., additional, Postma, A. A., additional, Compter, I., additional, Hoeijmakers, J. G. J., additional, Beckervordersandforth, J., additional, Broen, M. P. G., additional, and Schijns, O. E. M. G., additional
- Published
- 2021
- Full Text
- View/download PDF
6. In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report
- Author
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Haeren, R. H. L., Haeren, R. H. L., Rijkers, K., Schijns, O. E. M. G., Dings, J., Hoogland, G., van Zandvoort, M. A. M. J., Vink, H., van Overbeeke, J. J., Haeren, R. H. L., Haeren, R. H. L., Rijkers, K., Schijns, O. E. M. G., Dings, J., Hoogland, G., van Zandvoort, M. A. M. J., Vink, H., and van Overbeeke, J. J.
- Abstract
Introduction: The cerebral microcirculation and its glycocalyx, a matrix coating the luminal endothelium, are key regulators of capillary permeability and cerebral blood flow. Microvascular abnormalities are described in several neurological disorders. However, assessment of the cerebral microcirculation and glycocalyx has mainly been performed ex vivo. New method: Here, the technical feasibility of in vivo assessment of the human cerebral microcirculation and its glycocalyx using sidestream dark field (SDF) imaging is discussed. Intraoperative assessment requires the application of a sterile drape covering the camera (slipcover). First, sublingual measurements with and without slipcover were performed in a healthy control to assess the impact of this slipcover. Subsequently, using SDF imaging, the sublingual (reference), cortical, and hippocampal microcirculation and glycocalyx were evaluated in patients who underwent resective brain surgery as treatment for drug-resistant temporal lobe epilepsy. Finally, vessel density, and the perfused boundary region (PBR), a validated gauge of glycocalyx health, were calculated using GlycoCheck (c) software. Results: The addition of a slipcover affects vessel density and PBR values in a control subject. The cerebral measurements in five patients were more difficult to obtain than the sublingual ones. This was probably at least partly due to the introduction of a sterile slipcover. Results on vessel density and PBR showed similar patterns at all three measurement sites. Comparison with existing methods: This is the first report on in vivo assessment of the human cerebrovascular glycocalyx. Assessment of the glycocalyx is an additional application of in vivo imaging of the cerebral microcirculation using SDF technique. This method enables functional analysis of the microcirculation and glycocalyx, however the addition of a sterile slipcover affects the measurements. Conclusions: SDF imaging is a safe, quick, and straightforward t
- Published
- 2018
7. Protocol for intraoperative assessment of the human cerebrovascular glycocalyx
- Author
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Haeren, R. H. L., Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., Schijns, O. E. M. G., Haeren, R. H. L., Haeren, R. H. L., Vink, H., Staals, J., van Zandvoort, M. A. M. J., Dings, J., van Overbeeke, J. J., Hoogland, G., Rijkers, K., and Schijns, O. E. M. G.
- Abstract
Introduction: Adequate functioning of the blood-brain barrier (BBB) is important for brain homoeostasis and normal neuronal function. Disruption of the BBB has been described in several neurological diseases. Recent reports suggest that an increased permeability of the BBB also contributes to increased seizure susceptibility in patients with epilepsy. The endothelial glycocalyx is coating the luminal side of the endothelium and can be considered as the first barrier of the BBB. We hypothesise that an altered glycocalyx thickness plays a role in the aetiology of temporal lobe epilepsy (TLE), the most common type of epilepsy. Here, we propose a protocol that allows intraoperative assessment of the cerebrovascular glycocalyx thickness in patients with TLE and assess whether its thickness is decreased in patients with TLE when compared with controls.Methods and analysis: This protocol is designed as a prospective observational case-control study in patients who undergo resective brain surgery as treatment for TLE. Control subjects are patients without a history of epileptic seizures, who undergo a craniotomy or burr hole surgery for other indications. Intraoperative glycocalyx thickness measurements of sublingual, cortical and hippocampal microcirculation are performed by video microscopy using sidestream dark-field imaging. Demographic details, seizure characteristics, epilepsy risk factors, intraoperative haemodynamic parameters and histopathological evaluation are additionally recorded.Ethics and dissemination: This protocol has been ethically approved by the local medical ethical committee (ID: NL51594.068.14) and complies with the Declaration of Helsinki and principles of Good Clinical Practice. Informed consent is obtained before study enrolment and only coded data will be stored in a secured database, enabling an audit trail. Results will be submitted to international peer-reviewed journals and presented at international conferences.
- Published
- 2017
8. Integration of 7T MRI into image-guided radiotherapy of glioblastoma: a feasibility study
- Author
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Compter, I., Peerlings, J., Eekers, D. B. P., Postma, A. A., Ivanov, D., Wiggins, C., Kubben, P., Küsters, B., Wesseling, P., Ackermans, L., Schijns, O. E. M. G., Lambin, P., and Hoffmann, A. L.
- Published
- 2016
9. Protocol for intraoperative assessment of the human cerebrovascular glycocalyx
- Author
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Haeren, R H L, primary, Vink, H, additional, Staals, J, additional, van Zandvoort, M A M J, additional, Dings, J, additional, van Overbeeke, J J, additional, Hoogland, G, additional, Rijkers, K, additional, and Schijns, O E M G, additional
- Published
- 2017
- Full Text
- View/download PDF
10. Technical feasibility of integrating 7 T anatomical MRI in image‑guided radiotherapy of glioblastoma: a preparatory study
- Author
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Compter, I., Peerlings, J., Eekers, D. B. P., Postma, A. A., Ivanov, D., Wiggins, C. J., Kubben, P., Küsters, B., Wesseling, P., Ackermans, L., Schijns, O. E. M. G., Lambin, P., Hoffmann, A. L., Compter, I., Peerlings, J., Eekers, D. B. P., Postma, A. A., Ivanov, D., Wiggins, C. J., Kubben, P., Küsters, B., Wesseling, P., Ackermans, L., Schijns, O. E. M. G., Lambin, P., and Hoffmann, A. L.
- Abstract
Objectives: The use of 7 Tesla (T) magnetic resonance imaging (MRI) has recently shown great potential for high-resolution soft-tissue neuroimaging and visualization of microvascularization in glioblastoma (GBM). We have designed a clinical trial to explore the value of 7 T MRI in radiation treatment of GBM. For this aim we performed a preparatory study to investigate the technical feasibility of incorporating 7 T MR images into the neurosurgical navigation and radiotherapy treatment planning (RTP) systems via qualitative and quantitative assessment of the image quality. Materials and methods: The MR images were acquired with a Siemens Magnetom 7 T whole-body scanner and a Nova Medical 32-channel head coil. The 7 T MRI pulse sequences included magnetization-prepared two rapid acquisition gradient echoes (MP2RAGE), T2-SPACE, SPACE-FLAIR and gradient echo sequences (GRE). A pilot study with three healthy volunteers and an anthropomorphic 3D phantom was used to assess image quality and geometrical image accuracy. Results: The MRI scans were well tolerated by the volunteers. Susceptibility artefacts were observed in both the cortex and subcortical white matter at close proximity to air-tissue interfaces. Regional loss of signal and contrast could be minimized by the use of dielectric pads. Image transfer and processing did not degrade image quality. The system-related spatial uncertainty of geometrical distortion-corrected MP2RAGE pulse sequences was ≤2 mm. Conclusion: Integration of high-quality and geometrically-reliable 7 T MR images into neurosurgical navigation and RTP software is technically feasible and safe.
- Published
- 2016
11. A teenage girl with drug-resistant epilepsy and a hippocampal angiocentric neuroepithelial tumor (ANET) - illustrative case of 7T MRI in clinical practice.
- Author
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Hoeberigs MC, Beckervordersandforth JC, de Bruyn G, Klinkenberg S, and Schijns OEMG
- Subjects
- Humans, Female, Adolescent, Magnetic Resonance Imaging, Neoplasms, Neuroepithelial diagnostic imaging, Neoplasms, Neuroepithelial complications, Brain Neoplasms diagnostic imaging, Brain Neoplasms complications, Drug Resistant Epilepsy diagnostic imaging, Hippocampus diagnostic imaging, Hippocampus pathology
- Abstract
Competing Interests: Declaration of competing interest None of the authors has any conflict of interest to disclose
- Published
- 2024
- Full Text
- View/download PDF
12. Societal costs and quality of life analysis in patients undergoing resective epilepsy surgery: A one-year follow-up.
- Author
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Maas L, Kellenaers J, van Mastrigt G, van Kuijk SMJ, Vlooswijk MCG, Hiligsmann M, Klinkenberg S, Wagner L, Nelissen J, Schijns OEMG, Majoie HJM, and Rijkers K
- Abstract
Although effectiveness of Resective Epilepsy Surgery (RES) for patients with drug-resistant epilepsy (DRE) is widely proven, research on the impact of societal costs (SC) is lacking. The aim of this study is to provide both clinical and economic outcomes of RES by offering an overview of treatment effectiveness as well as SC of RES in a cohort of 30 Dutch DRE patients. This project serves as a pilot project to offer an up-to-date model for larger cost-effectiveness studies. Medical consumption, productivity losses, disease-specific and generic health-related quality of life (QoL), and seizure frequency were assessed before and 3-, 6-, and 12-months post-surgery with validated questionnaires. Linear mixed models, ANOVAs, and logistic regressions were performed. SC for the first year after RES entailed €54,376 and decreased over time. Moreover, 50% of patients experienced a clinically important increase in disease-specific QoL and 53% of patients in generic health-related QoL. Lastly, 73% of patients reached seizure freedom 12 months postoperative. Seizure reduction was correlated with increase in disease-specific QoL. Within one year after surgery, RES leads to reduction in SC and improvements in QoL over time. Future research should encompass longer follow-up periods, larger sample size, and a cost-effectiveness analysis with a comparator., Competing Interests: Mickaël Hiligsmann has received research grants paid to his institution by Amgen, Radius Health and Angelini Pharma, advisory grant from Pfizer (paid to institution), lecture fees (paid to institution) from IBSA, all outside the current work. All other authors declare no conflicts of interest. This study was not funded.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors.)
- Published
- 2023
- Full Text
- View/download PDF
13. Ultra-high field magnetic resonance imaging in human epilepsy: A systematic review.
- Author
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van Lanen RHGJ, Colon AJ, Wiggins CJ, Hoeberigs MC, Hoogland G, Roebroeck A, Ivanov D, Poser BA, Rouhl RPW, Hofman PAM, Jansen JFA, Backes W, Rijkers K, and Schijns OEMG
- Subjects
- Follow-Up Studies, Humans, Magnetic Resonance Imaging, Prospective Studies, Retrospective Studies, Treatment Outcome, Drug Resistant Epilepsy diagnostic imaging, Drug Resistant Epilepsy surgery, Epilepsy diagnostic imaging
- Abstract
Rationale: Resective epilepsy surgery is an evidence-based curative treatment option for patients with drug-resistant focal epilepsy. The major preoperative predictor of a good surgical outcome is detection of an epileptogenic lesion by magnetic resonance imaging (MRI). Application of ultra-high field (UHF) MRI, i.e. field strengths ≥ 7 Tesla (T), may increase the sensitivity to detect such a lesion., Methods: A keyword search strategy was submitted to Pubmed, EMBASE, Cochrane Database and clinicaltrials.gov to select studies on UHF MRI in patients with epilepsy. Follow-up study selection and data extraction were performed following PRISMA guidelines. We focused on I) diagnostic gain of UHF- over conventional MRI, II) concordance of MRI-detected lesion, seizure onset zone and surgical decision-making, and III) postoperative histopathological diagnosis and seizure outcome., Results: Sixteen observational cohort studies, all using 7T MRI were included. Diagnostic gain of 7T over conventional MRI ranged from 8% to 67%, with a pooled gain of 31%. Novel techniques to visualize pathological processes in epilepsy and lesion detection are discussed. Seizure freedom was achieved in 73% of operated patients; no seizure outcome comparison was made between 7T MRI positive, 7T negative and 3T positive patients. 7T could influence surgical decision-making, with high concordance of lesion and seizure onset zone. Focal cortical dysplasia (54%), hippocampal sclerosis (12%) and gliosis (8.1%) were the most frequently diagnosed histopathological entities., Significance: UHF MRI increases, yet variably, the sensitivity to detect an epileptogenic lesion, showing potential for use in clinical practice. It remains to be established whether this results in improved seizure outcome after surgical treatment. Prospective studies with larger cohorts of epilepsy patients, uniform scan and sequence protocols, and innovative post-processing technology are equally important as further increasing field strengths. Besides technical ameliorations, improved correlation of imaging features with clinical semiology, histopathology and clinical outcome has to be established., (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
14. In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report.
- Author
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Haeren RHL, Rijkers K, Schijns OEMG, Dings J, Hoogland G, van Zandvoort MAMJ, Vink H, and van Overbeeke JJ
- Subjects
- Adult, Case-Control Studies, Female, Humans, Male, Microscopy, Video methods, Middle Aged, Blood-Brain Barrier physiology, Cerebrovascular Circulation physiology, Epilepsy diagnostic imaging, Epilepsy surgery, Glycocalyx physiology, Intraoperative Neurophysiological Monitoring methods, Microcirculation physiology, Neuroimaging methods, Neurosurgical Procedures methods
- Abstract
Introduction: The cerebral microcirculation and its glycocalyx, a matrix coating the luminal endothelium, are key regulators of capillary permeability and cerebral blood flow. Microvascular abnormalities are described in several neurological disorders. However, assessment of the cerebral microcirculation and glycocalyx has mainly been performed ex vivo., New Method: Here, the technical feasibility of in vivo assessment of the human cerebral microcirculation and its glycocalyx using sidestream dark field (SDF) imaging is discussed. Intraoperative assessment requires the application of a sterile drape covering the camera (slipcover). First, sublingual measurements with and without slipcover were performed in a healthy control to assess the impact of this slipcover. Subsequently, using SDF imaging, the sublingual (reference), cortical, and hippocampal microcirculation and glycocalyx were evaluated in patients who underwent resective brain surgery as treatment for drug-resistant temporal lobe epilepsy. Finally, vessel density, and the perfused boundary region (PBR), a validated gauge of glycocalyx health, were calculated using GlycoCheck
© software., Results: The addition of a slipcover affects vessel density and PBR values in a control subject. The cerebral measurements in five patients were more difficult to obtain than the sublingual ones. This was probably at least partly due to the introduction of a sterile slipcover. Results on vessel density and PBR showed similar patterns at all three measurement sites., Comparison With Existing Methods: This is the first report on in vivo assessment of the human cerebrovascular glycocalyx. Assessment of the glycocalyx is an additional application of in vivo imaging of the cerebral microcirculation using SDF technique. This method enables functional analysis of the microcirculation and glycocalyx, however the addition of a sterile slipcover affects the measurements., Conclusions: SDF imaging is a safe, quick, and straightforward technique to evaluate the functional cerebral microcirculation and glycocalyx. Because of their eminent role in cerebral homeostasis, this method may significantly add to research on the role of vascular pathophysiology underling various neurological disorders., (Copyright © 2018 Elsevier B.V. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
15. The influence of neuropathology on brain inflammation in human and experimental temporal lobe epilepsy.
- Author
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Aalbers MW, Rijkers K, Majoie HJ, Dings JT, Schijns OE, Schipper S, De Baets MH, Kessels A, Vles JS, and Hoogland G
- Subjects
- Adult, Amygdala physiology, Animals, CD11b Antigen metabolism, Electric Stimulation adverse effects, Female, Fluorodeoxyglucose F18, Glial Fibrillary Acidic Protein metabolism, Humans, Kindling, Neurologic physiology, Male, Middle Aged, Positron-Emission Tomography, Rats, Rats, Sprague-Dawley, Cytokines metabolism, Encephalitis etiology, Encephalitis pathology, Epilepsy, Temporal Lobe complications, Epilepsy, Temporal Lobe pathology, Hippocampus pathology
- Abstract
It is unclear to what extent neuropathological changes contribute to brain inflammation observed in temporal lobe epilepsy (TLE). Here, we compared cytokine levels between histopathologically-confirmed sclerotic hippocampi and histopathologically-confirmed normal hippocampi from TLE patients. We analyzed a similar cytokine panel in the hippocampi of amygdala-kindled rats and we evaluated neuropathological changes by immunohistochemistry. In TLE patients, cytokine levels were not significantly different between sclerotic and non-sclerotic hippocampi. Though kindling resulted in increased astrocyte activation, cytokine levels and microglia activation were unchanged. These results suggest that the chronic epileptic state in TLE can also occur in the absence of intracerebral inflammation. Highlights., (Copyright © 2014 Elsevier B.V. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
16. Surgery for temporal lobe epilepsy after cerebral malaria.
- Author
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Schijns OE, Visser-Vandewalle V, Lemmens EM, Janssen A, and Hoogland G
- Subjects
- Humans, Magnetic Resonance Imaging methods, Male, Middle Aged, Temporal Lobe pathology, Temporal Lobe surgery, Epilepsy, Temporal Lobe etiology, Epilepsy, Temporal Lobe microbiology, Epilepsy, Temporal Lobe surgery, Malaria, Cerebral complications
- Abstract
The most common indication for epilepsy surgery is temporal lobe epilepsy (TLE) which usually is divided into two categories, mesial and lateral TLE. The commonest pathology underlying mesial temporal lobe epilepsy (MTLE) is mesial temporal sclerosis (MTS); we report on a 50-year-old male patient, who contracted cerebral malaria and developed MTLE shortly thereafter. Magnetic resonance imaging (MRI) showed MTS. Surgical treatment was an anteromedial temporal lobe resection with amygdalohippocampectomy. The patient is seizure free, 36 months after surgical treatment. This is the first report describing MTLE-onset subsequent to cerebral malaria and discussing the potential pathophysiological relationship between cerebral malaria and MTS.
- Published
- 2008
- Full Text
- View/download PDF
17. [Parinaud's syndrome as a sign of acute obstructive hydrocephalus: recovery after acute ventriculostomy].
- Author
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Schijns OE and Beuls EA
- Subjects
- Adolescent, Adult, Female, Humans, Hydrocephalus surgery, Male, Middle Aged, Ocular Motility Disorders surgery, Treatment Outcome, Hydrocephalus complications, Ocular Motility Disorders etiology, Ventriculostomy methods
- Abstract
Paresis or palsy of upward vertical gaze, pupillary light-near dissociation and nystagmus retractorius with convergence, were present in a boy aged 16 years and a woman aged 30 years with an obstructive hydrocephalus due to an aqueductal stenosis as a consequence of a bacterial meningitis and in a woman aged 26 years and a man aged 47 years with an outlet obstruction of the fourth ventricle after a posterior fossa operation for a tumour in the fourth ventricle. All of the patients were suspected of having a drain dysfunction. They all underwent a third-ventriculocisternostomy after which their symptoms (partially) resolved. The presenting symptoms stated are the classical triad of Parinaud's syndrome. In addition to these there are less frequent symptoms such as bilateral eyelid retraction (Collier's sign) and convergence spasms. The syndrome is rare but has a significant mortality risk and a high morbidity rate if an obstructive hydrocephalus is not diagnosed and treated. An MRI scan of the cerebrum to detect obstructive hydrocephalus with dilation of the aqueduct is the diagnostic of choice. For an obstructive hydrocephalus with dilation of the aqueduct a third-ventriculocisternostomy is the treatment of choice.
- Published
- 2002
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