Search

Your search keyword '"Schininà, Vincenzo"' showing total 44 results
Start Over Author "Schininà, Vincenzo"
44 results on '"Schininà, Vincenzo"'

1. An Explainable AI System for Automated COVID-19 Assessment and Lesion Categorization from CT-scans

Author

Pennisi, Matteo, Kavasidis, Isaak, Spampinato, Concetto, Schininà, Vincenzo, Palazzo, Simone, Rundo, Francesco, Cristofaro, Massimo, Campioni, Paolo, Pianura, Elisa, Di Stefano, Federica, Petrone, Ada, Albarello, Fabrizio, Ippolito, Giuseppe, Cuzzocrea, Salvatore, and Conoci, Sabrina

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

COVID-19 infection caused by SARS-CoV-2 pathogen is a catastrophic pandemic outbreak all over the world with exponential increasing of confirmed cases and, unfortunately, deaths. In this work we propose an AI-powered pipeline, based on the deep-learning paradigm, for automated COVID-19 detection and lesion categorization from CT scans. We first propose a new segmentation module aimed at identifying automatically lung parenchyma and lobes. Next, we combined such segmentation network with classification networks for COVID-19 identification and lesion categorization. We compare the obtained classification results with those obtained by three expert radiologists on a dataset consisting of 162 CT scans. Results showed a sensitivity of 90\% and a specificity of 93.5% for COVID-19 detection, outperforming those yielded by the expert radiologists, and an average lesion categorization accuracy of over 84%. Results also show that a significant role is played by prior lung and lobe segmentation that allowed us to enhance performance by over 20 percent points. The interpretation of the trained AI models, moreover, reveals that the most significant areas for supporting the decision on COVID-19 identification are consistent with the lesions clinically associated to the virus, i.e., crazy paving, consolidation and ground glass. This means that the artificial models are able to discriminate a positive patient from a negative one (both controls and patients with interstitial pneumonia tested negative to COVID) by evaluating the presence of those lesions into CT scans. Finally, the AI models are integrated into a user-friendly GUI to support AI explainability for radiologists, which is publicly available at http://perceivelab.com/covid-ai.

Published
2021

2. Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia

Author

Camici, Marta, Zuppi, Paolo, Lorenzini, Patrizia, Scarnecchia, Liliana, Pinnetti, Carmela, Cicalini, Stefania, Nicastri, Emanuele, Petrosillo, Nicola, Palmieri, Fabrizio, D’Offizi, Gianpiero, Marchioni, Luisa, Gagliardini, Roberta, Baldelli, Roberto, Schininà, Vincenzo, Pianura, Elisa, Di Stefano, Federica, Curcio, Stefano, Ciavarella, Lucia, Ippolito, Giuseppe, Girardi, Enrico, Vaia, Francesco, and Antinori, Andrea

Published
2021
Full Text
View/download PDF

3. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
Full Text
View/download PDF

4. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
Full Text
View/download PDF

10. Imaging Severity COVID-19 Assessment in Vaccinated and Unvaccinated Patients: Comparison of the Different Variants in a High Volume Italian Reference Center

Author

Granata, Vincenza, primary, Fusco, Roberta, additional, Villanacci, Alberta, additional, Magliocchetti, Simona, additional, Urraro, Fabrizio, additional, Tetaj, Nardi, additional, Marchioni, Luisa, additional, Albarello, Fabrizio, additional, Campioni, Paolo, additional, Cristofaro, Massimo, additional, Di Stefano, Federica, additional, Fusco, Nicoletta, additional, Petrone, Ada, additional, Schininà, Vincenzo, additional, Grassi, Francesca, additional, Girardi, Enrico, additional, and Ianniello, Stefania, additional

Published
2022
Full Text
View/download PDF

11. Quantitative Analysis of Residual COVID-19 Lung CT Features: Consistency among Two Commercial Software

Author

Granata, Vincenza, primary, Ianniello, Stefania, additional, Fusco, Roberta, additional, Urraro, Fabrizio, additional, Pupo, Davide, additional, Magliocchetti, Simona, additional, Albarello, Fabrizio, additional, Campioni, Paolo, additional, Cristofaro, Massimo, additional, Di Stefano, Federica, additional, Fusco, Nicoletta, additional, Petrone, Ada, additional, Schininà, Vincenzo, additional, Villanacci, Alberta, additional, Grassi, Francesca, additional, Grassi, Roberta, additional, and Grassi, Roberto, additional

Published
2021
Full Text
View/download PDF

13. Management of Spontaneous Bleeding in COVID-19 Inpatients: Is Embolization Always Needed?

Author

Riu, Pascale, primary, Albarello, Fabrizio, additional, Di Stefano, Federica, additional, Vergori, Alessandra, additional, D’Abramo, Alessandra, additional, Cerini, Carlo, additional, Nocioni, Martina, additional, Morucci, Maurizio, additional, Tetaj, Nardi, additional, Cristofaro, Massimo, additional, Schininà, Vincenzo, additional, Campioni, Paolo, additional, Petrone, Ada, additional, Fusco, Nicoletta, additional, Marchioni, Luisa, additional, Antinori, Andrea, additional, Nicastri, Emanuele, additional, Cianni, Roberto, additional, and Ianniello, Stefania, additional

Published
2021
Full Text
View/download PDF

15. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
Full Text
View/download PDF

16. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
Full Text
View/download PDF

17. Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia

Author

Vergori, Alessandra, primary, Lorenzini, Patrizia, additional, Lepri, Alessandro Cozzi, additional, Donno, Davide Roberto, additional, Gualano, Gina, additional, Nicastri, Emanuele, additional, Iacomi, Fabio, additional, Marchioni, Luisa, additional, Campioni, Paolo, additional, Schininà, Vincenzo, additional, Cicalini, Stefania, additional, Agrati, Chiara, additional, Capobianchi, Maria Rosaria, additional, Girardi, Enrico, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Petrosillo, Nicola, additional, Antinori, Andrea, additional, and Taglietti, Fabrizio, additional

Published
2020
Full Text
View/download PDF

18. Association of Sarcopenia and Body Composition With Short-term Outcomes After Liver Resection for Malignant Tumors

Author

Berardi, Giammauro, primary, Antonelli, Giulio, additional, Colasanti, Marco, additional, Meniconi, Roberto, additional, Guglielmo, Nicola, additional, Laurenzi, Andrea, additional, Ferretti, Stefano, additional, Levi Sandri, Giovanni Battista, additional, Spagnoli, Alessandra, additional, Moschetta, Giovanni, additional, Schininà, Vincenzo, additional, Antonini, Mario, additional, Marignani, Massimo, additional, and Ettorre, Giuseppe Maria, additional

Published
2020
Full Text
View/download PDF

19. COVID‐19 in people living with HIV: Clinical implications of dynamics of the immune response to SARS‐CoV‐2

Author

Mondi, Annalisa, primary, Cimini, Eleonora, additional, Colavita, Francesca, additional, Cicalini, Stefania, additional, Pinnetti, Carmela, additional, Matusali, Giulia, additional, Casetti, Rita, additional, Maeurer, Markus, additional, Vergori, Alessandra, additional, Mazzotta, Valentina, additional, Gagliardini, Roberta, additional, De Zottis, Federico, additional, Schininà, Vincenzo, additional, Girardi, Enrico, additional, Puro, Vincenzo, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Capobianchi, Maria Rosaria, additional, Castilletti, Concetta, additional, Agrati, Chiara, additional, and Antinori, Andrea, additional

Published
2020
Full Text
View/download PDF

20. Central Nervous System involvement in tuberculosis: An MRI study considering differences between patients with and without Human Immunodeficiency Virus 1 infection

Author

Di Napoli, Alberto, primary, Cristofaro, Massimo, additional, Romano, Andrea, additional, Pianura, Elisa, additional, Papale, Gioia, additional, Di Stefano, Federica, additional, Ronconi, Edoardo, additional, Petrone, Ada, additional, Rossi Espagnet, Maria Camilla, additional, Schininà, Vincenzo, additional, and Bozzao, Alessandro, additional

Published
2020
Full Text
View/download PDF

21. Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital

Author

Di Gennaro, Francesco, primary, Vittozzi, Pietro, additional, Gualano, Gina, additional, Musso, Maria, additional, Mosti, Silvia, additional, Mencarini, Paola, additional, Pareo, Carlo, additional, Di Caro, Antonino, additional, Schininà, Vincenzo, additional, Girardi, Enrico, additional, and Palmieri, Fabrizio, additional

Published
2020
Full Text
View/download PDF

22. Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study

Author

Wu, Guangyao, primary, Yang, Pei, additional, Xie, Yuanliang, additional, Woodruff, Henry C., additional, Rao, Xiangang, additional, Guiot, Julien, additional, Frix, Anne-Noelle, additional, Louis, Renaud, additional, Moutschen, Michel, additional, Li, Jiawei, additional, Li, Jing, additional, Yan, Chenggong, additional, Du, Dan, additional, Zhao, Shengchao, additional, Ding, Yi, additional, Liu, Bin, additional, Sun, Wenwu, additional, Albarello, Fabrizio, additional, D'Abramo, Alessandra, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Occhipinti, Mariaelena, additional, Barisione, Giovanni, additional, Barisione, Emanuela, additional, Halilaj, Iva, additional, Lovinfosse, Pierre, additional, Wang, Xiang, additional, Wu, Jianlin, additional, and Lambin, Philippe, additional

Published
2020
Full Text
View/download PDF

24. Coronavirus-HKU1 Pneumonia and Differential Diagnosis with COVID-19

Author

Pianura, Elisa, primary, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Fusco, Nicoletta, additional, Albarello, Fabrizio, additional, Lapa, Daniele, additional, Cicalini, Stefania, additional, Campioni, Paolo, additional, and Schininà, Vincenzo, additional

Published
2020
Full Text
View/download PDF

25. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Albarello, Fabrizio, primary, Pianura, Elisa, additional, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Marchioni, Luisa, additional, Palazzolo, Claudia, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Petrosillo, Nicola, additional, Campioni, Paolo, additional, Eskild, Petersen, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Abbonizio, Maria Alessandra, additional, Agrati, Chiara, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonini, Mario, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Branca, Marta, additional, Capobianchi, Maria Rosaria, additional, Caporale, Cinzia, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Chiappini, Roberta, additional, Ciaralli, Carmine, additional, Colavita, Francesca, additional, Corpolongo, Angela, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, Angelis, Alessia De, additional, Angelis, Giada De, additional, Lorenzo, Rachele Di, additional, Stefano, Federica Di, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Greci, Maria Cristina, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Marani, Alessandra, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Matusali, Giulia, additional, Meschi, Silvia, additional, Montaldo, Francesco Messina Chiara, additional, Murachelli, Silvia, additional, Noto, Roberto, additional, Pallini, Emanuele, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Petrecchia, Antonella, additional, Pisciotta, Maria, additional, Pittalis, Silvia, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Rinonapoli, Gabriele, additional, Rueca, Martina, additional, Sacchi, Alessandra, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarcia, Silvana, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Vaia, Francesco, additional, Vairo, Francesco, additional, and Valli, Maria Beatrice, additional

Published
2020
Full Text
View/download PDF

28. Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia.

Author

Vergori, Alessandra, Lorenzini, Patrizia, Cozzi-Lepri, Alessandro, Donno, Davide Roberto, Gualano, Gina, Nicastri, Emanuele, Iacomi, Fabio, Marchioni, Luisa, Campioni, Paolo, Schininà, Vincenzo, Cicalini, Stefania, Agrati, Chiara, Capobianchi, Maria Rosaria, Girardi, Enrico, Ippolito, Giuseppe, Vaia, Francesco, Petrosillo, Nicola, Antinori, Andrea, Taglietti, Fabrizio, and The ReCOVeRI Study Group

Subjects
HEPARIN, COVID-19, PNEUMONIA, SARS-CoV-2, ANTI-inflammatory agents
Abstract

Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50–77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2–26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7–15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO2/FiO2 ratio: aHR 1.40 (95% CI 0.51–3.79) for patients with an admission PaO2/FiO2 ≤ 300 mmHg and 0.27 (0.03–2.18) for those with PaO2/FiO2 > 300 mmHg; p-value at interaction test 0.16. pLMWH does not seem to reduce the risk of OTI/death mild/moderate COVID-19 pneumonia, especially when respiratory function had already significantly deteriorated. Data from clinical trials comparing the effect of prophylactic vs. therapeutic dosage of LMWH at various stages of COVID-19 disease are needed. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

29. COVID‐19 in people living with HIV: Clinical implications of dynamics of the immune response to SARS‐CoV‐2.

Author

Mondi, Annalisa, Cimini, Eleonora, Colavita, Francesca, Cicalini, Stefania, Pinnetti, Carmela, Matusali, Giulia, Casetti, Rita, Maeurer, Markus, Vergori, Alessandra, Mazzotta, Valentina, Gagliardini, Roberta, De Zottis, Federico, Schininà, Vincenzo, Girardi, Enrico, Puro, Vincenzo, Ippolito, Giuseppe, Vaia, Francesco, Capobianchi, Maria Rosaria, Castilletti, Concetta, and Agrati, Chiara

Subjects
COVID-19, SARS-CoV-2, IMMUNE reconstitution inflammatory syndrome, IMMUNE response, HIV infections, HIV
Abstract

Little evidence on coronavirus disease 2019 (COVID‐19) in people living with HIV (PLWH) is currently available. We reported clinical and viroimmunological data of all HIV‐positive patients admitted to our center with COVID‐19 from March 1 to May 12, 2020. Overall, five patients were included: all were virologically‐suppressed on antiretroviral therapy and CD4+ count was greater than 350 cell/mm3 in all but two patients. Although all patients had evidence of pneumonia on admission, only one developed respiratory failure. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA was never detected from nasopharyngeal swabs in two patients, whereas in the others, viral clearance occurred within a maximum of 43 days. Immunoglobulin G production was elicited in all patients and neutralizing antibodies in all but one patient. Specific‐T‐cell response developed in all patients but was stronger in those with the more severe presentations. Similarly, the highest level of proinflammatory cytokines was found in the only patient experiencing respiratory failure. Despite a mild presentation, patients with more pronounced immunosuppression showed high degrees of both cytokines production and immune activation. Our study did not find an increased risk and severity of COVID‐19 in PLWH. Adaptative cellular immune response to SARS‐CoV‐2 appeared to correlate to disease severity. The mild clinical picture showed in advanced HIV patients, despite a significant T‐cell activation and inflammatory profile, suggests a potential role of HIV‐driven immunological dysregulation in avoiding immune‐pathogenetic processes. However, other possible explanations, as a protective role of certain antiretroviral drugs, should be considered. Further larger studies are needed to better clarify the impact of HIV infection on COVID‐19. Highlights: The clinical course of COVID‐19 and the dynamics of the immune response to SARS‐CoV‐2 infection in people living with HIV have not yet been fully elucidated Indeed, although worse outcomes might be expected in HIV‐positive patients compared to the general population, it has been supposed that the HIV‐related immune dysregulation could paradoxically mitigate the hyperinflammation syndrome responsible for the most severe complications of SARS‐CoV‐2 infection.In this case series we did not find an increased risk of both acquiring and having a severe course of COVID‐19 in people living with HIV compared to how reported in the general population.We observed that patients with more severe HIV‐related immunosuppression, despite the development of a specific immune response and the presence of a strong cellular immune‐activation and a moderate inflammatory profile, experienced a mild/moderate disease. These findings might suggest that the lower and impaired immune reactivity of advanced HIV infection could contribute to avoid immune‐pathogenetic processes. However, other possible explanations, as a potential protective role of certain antiretroviral regimens, should be considered. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

30. Pulmonary mycosis in AIDS

Author

Busi Rizzi, Elisa, Schininà, Vincenzo, Bellussi, Angelo, De Santis, Andrea, Mazzuoli, Giovanna, Giosué, Sandro, and Bibbolino, Corrado

Published
2001
Full Text
View/download PDF

31. Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Author

Abbonizio, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vita, Serena, Di Bari, Virginia, Goletti, Delia, Espinosa, Joaquin, Petracca, Sebastiano, and Palmieri, Fabrizio

Published
2021
Full Text
View/download PDF

33. Polyfunctional Specific Response to Echinococcus Granulosus Associates to the Biological Activity of the Cysts

Author

Petrone, Linda, primary, Vanini, Valentina, additional, Petruccioli, Elisa, additional, Ettorre, Giuseppe Maria, additional, Schininà, Vincenzo, additional, Busi Rizzi, Elisa, additional, Ludovisi, Alessandra, additional, Corpolongo, Angela, additional, Ippolito, Giuseppe, additional, Pozio, Edoardo, additional, Teggi, Antonella, additional, and Goletti, Delia, additional

Published
2015
Full Text
View/download PDF

34. IL-4 specific-response in whole blood associates with human Cystic Echinococcosis and cyst activity

Author

Petrone, Linda, primary, Vanini, Valentina, additional, Petruccioli, Elisa, additional, Ettorre, Giuseppe Maria, additional, Busi Rizzi, Elisa, additional, Schininà, Vincenzo, additional, Girardi, Enrico, additional, Ludovisi, Alessandra, additional, Gómez-Morales, María Ángeles, additional, Pozio, Edoardo, additional, Teggi, Antonella, additional, and Goletti, Delia, additional

Published
2015
Full Text
View/download PDF

36. Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy

Author

Petrone, Linda, primary, Cuzzi, Gilda, additional, Colace, Lidia, additional, Ettorre, Giuseppe Maria, additional, Busi-Rizzi, Elisa, additional, Schininà, Vincenzo, additional, Pucillo, Leopoldo, additional, Angeletti, Claudio, additional, Pane, Stefania, additional, Di Caro, Antonino, additional, Bordi, Eugenio, additional, Girardi, Enrico, additional, Pozio, Edoardo, additional, Corpolongo, Angela, additional, Teggi, Antonella, additional, Brunetti, Enrico, additional, and Goletti, Delia, additional

Published
2013
Full Text
View/download PDF

37. IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country

Author

Vanini, Valentina, primary, Petruccioli, Elisa, additional, Gioia, Cristiana, additional, Cuzzi, Gilda, additional, Orchi, Nicoletta, additional, Rianda, Alessia, additional, Alba, Lucia, additional, Giancola, Maria Letizia, additional, Conte, Aristide, additional, Schininà, Vincenzo, additional, Busi Rizzi, Elisa, additional, Girardi, Enrico, additional, and Goletti, Delia, additional

Published
2012
Full Text
View/download PDF

38. Progressive Multifocal Leukoencephalopathy in HIV-Infected Patients in the Era of HAART: Radiological Features at Diagnosis and Follow-Up and Correlation with Clinical Variables

Author

Giancola, Maria Letizia, primary, Rizzi, Elisa Busi, additional, Lorenzini, Patrizia, additional, Rovighi, Laura, additional, Baldini, Francesco, additional, Schininà, Vincenzo, additional, Larussa, Dora, additional, Bibbolino, Corrado, additional, and Antinori, Andrea, additional

Published
2008
Full Text
View/download PDF

40. Reduced Value of Thallium-201 Single-Photon Emission Computed Tomography in the Management of HIV-Related Focal Brain Lesions in the Era of Highly Active Antiretroviral Therapy

Author

Giancola, Maria Letizia, primary, Rizzi, Elisa Busi, additional, Schiavo, Riccardo, additional, Lorenzini, Patrizia, additional, Schininà, Vincenzo, additional, Alba, Lucia, additional, del Grosso, Bruno, additional, Gigli, Beniamino, additional, Rosati, Silvia, additional, Mango, Lucio, additional, Bibbolino, Corrado, additional, and Antinori, Andrea, additional

Published
2004
Full Text
View/download PDF

44. Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response Kinetics

Author

Colavita, Francesca, Lapa, Daniele, Carletti, Fabrizio, Lalle, Eleonora, Messina, Francesco, Rueca, Martina, Matusali, Giulia, Meschi, Silvia, Bordi, Licia, Marsella, Patrizia, Nicastri, Emanuele, Marchioni, Luisa, Mariano, Andrea, Scorzolini, Laura, Ascoli Bartoli, Tommaso, Di Caro, Antonino, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Castilletti, Concetta, Abbate, Isabella, Agrati, Chiara, Aleo, Loredana, Alonzi, Tonino, Amendola, Alessandra, Apollonio, Claudia, Arduini, Nicolina, Bartolini, Barbara, Berno, Giulia, Biancone, Silvia, Biava, Mirella, Bibbò, Angela, Brega, Carla, Canali, Marco, Cannas, Angela, Carrara, Stefania, Casetti, Rita, Chiappini, Roberta, Ciafrone, Lucia, Cimini, Eleonora, Coen, Sabrina, Condello, Rossella, Coppola, Antonio, D’Arezzo, Silvia, Di Filippo, Stefania, Di Giuli, Chiara, Fabeni, Lavinia, Felici, Luisa, Ferraioli, Valeria, Forbici, Federica, Garbuglia, Anna Rosa, Giombini, Emanuela, Gori, Caterina, Graziano, Silvia, Gruber, Cesare Ernesto Maria, Khouri, Daniele, Leone, Barbara, Massimino, Chiara, Mazzarelli, Antonio, Minosse, Claudia, Montaldo, Claudia, Neri, Stefania, Nisii, Carla, Petrivelli, Elisabetta, Petroni, Fabrizio, Petruccioli, Elisa, Pisciotta, Marina, Pizzi, Daniele, Prota, Gianluca, Raparelli, Fabrizio, Rozera, Gabriella, Sabatini, Rossella, Sarti, Silvia, Sberna, Giuseppe, Sciamanna, Roberta, Selleri, Marina, Selvaggi, Carla, Sias, Catia, Stellitano, Chiara, Toffoletti, Antonietta, Truffa, Silvia, Turchi, Federica, Valli, Maria Beatrice, Venditti, Carolina, Vescovo, Tiziana, Vincenti, Donatella, Vulcano, Antonella, Zambelli, Emma, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Antonini, Mario, Barbaro, Raffaella, Benigni, Martina, Bevilacqua, Nazario, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Caporale, Cinzia, Caravella, Ilaria, Ciaralli, Carmine, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Greci, Maria Cristina, Lanini, Simone, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marini, Maria Cristina, Maritti, Micaela, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, and Vairo, Francesco

Subjects
0301 basic medicine, Immunoglobulin A, Immunoglobulin G, Virus, NO, Serology, 03 medical and health sciences, 0302 clinical medicine, Major Article, SARS-cov-2, Medicine, 030212 general & internal medicine, Viral shedding, Neutralizing antibody, Phylogenesis, biology, Viral culture, business.industry, Antibody response, COVID-19, Italy, Virus shedding, 3. Good health, AcademicSubjects/MED00290, 030104 developmental biology, Infectious Diseases, Oncology, Immunoglobulin M, Immunology, biology.protein, business
Abstract

Background The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy. Methods We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. Serological analysis was carried out on serial serum samples to evaluate IgM, IgA, IgG, and neutralizing antibody levels. Results SARS-CoV-2 RNA was detected since the early phase of illness, lasting over 2 weeks in both upper and lower respiratory tract samples. Virus isolate was obtained from acute respiratory samples, while no infectious virus was rescued from late respiratory samples with low viral RNA load, collected when serum antibodies had been developed. Several other specimens came back positive, including saliva, vomit, rectal, cutaneous, cervico-vaginal, and ocular swabs. IgM, IgA, and IgG were detected within the first week of diagnosis, with IgG appearing earlier and at higher titers. Neutralizing antibodies developed during the second week, reaching high titers 32 days after diagnosis. Conclusions Our longitudinal analysis showed that SARS-CoV-2 RNA can be detected in different body samples, which may be associated with broad tropism and different spectra of clinical manifestations and modes of transmission. Profiling antibody response and neutralizing activity can assist in laboratory diagnosis and surveillance actions.

Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results