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1. Serum Potassium and Risk of Death or Kidney Replacement Therapy in Older People With CKD Stages 4-5: Eight-Year Follow-up

Author

Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, de Rooij, Esther N.M., de Fijter, Johan W., Le Cessie, Saskia, Hoorn, Ewout J., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Windahl, Karin, Caskey, Fergus J., Szymczak, Maciej, Dekker, Friedo W., and Hoogeveen, Ellen K.

Published
2023
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2. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O'Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D'alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Hernandez, Isabel Bascaran, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, Aydin, Zeynep, Ramspek, Chava L., Boekee, Rosemarijn, Evans, Marie, Heimburger, Olof, Snead, Charlotte M., Caskey, Fergus J., Torino, Claudia, Szymczak, Maciej, Krajewska, Magdalena, Drechsler, Christiane, Wanner, Christoph, Chesnaye, Nicholas C., Jager, Kitty J., Dekker, Friedo W., Snoeijs, Maarten G.J., and Rotmans, Joris I.

Published
2022
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3. Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease

Author

Magagnoli, Lorenza, Cozzolino, Mario, Evans, Marie, Caskey, Fergus J., Dekker, Friedo W., Torino, Claudia, Szymczak, Maciej, Drechsler, Christiane, Pippias, Maria, Vilasi, Antonio, Janse, Roemer J., Krajewska, Magdalena, Stel, Vianda S., Jager, Kitty J., Chesnaye, Nicholas C., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Butti, Alessandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Abaterusso, Cataldo, Somma, Chiara, D'alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2024
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4. Serum Potassium and Risk of Death or Kidney Replacement Therapy in Older People With CKD Stages 4-5: Eight-Year Follow-up

Author

de Rooij, Esther N.M., primary, de Fijter, Johan W., additional, Le Cessie, Saskia, additional, Hoorn, Ewout J., additional, Jager, Kitty J., additional, Chesnaye, Nicholas C., additional, Evans, Marie, additional, Windahl, Karin, additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Szymczak, Maciej, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Dekker, Friedo W., additional, Hoogeveen, Ellen K., additional, Schneider, Andreas, additional, Torp, Anke, additional, Iwig, Beate, additional, Perras, Boris, additional, Marx, Christian, additional, Blaser, Christof, additional, Emde, Claudia, additional, Krieter, Detlef, additional, Fuchs, Dunja, additional, Irmler, Ellen, additional, Platen, Eva, additional, Schmidt-Gürtler, Hans, additional, Schlee, Hendrik, additional, Naujoks, Holger, additional, Schlee, Ines, additional, Cäsar, Sabine, additional, Beige, Joachim, additional, Röthele, Jochen, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Anding-Rost, Kirsten, additional, Schramm, Lothar, additional, Hopf, Monika, additional, Wuttke, Nadja, additional, Frischmuth, Nikolaus, additional, Ichtiaris, Pawlos, additional, Kirste, Petra, additional, Schulz, Petra, additional, Aign, Sabine, additional, Biribauer, Sandra, additional, Manan, Sherin, additional, Röser, Silke, additional, Heidenreich, Stefan, additional, Palm, Stephanie, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Seeger, Wolfgang, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Pignataro, Angelo, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Antonio, Bellasi, additional, Alessandra, Butti, additional, Abaterusso, Cataldo, additional, Somma, Chiara, additional, and D’alessandro, Claudia, additional

Published
2023
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5. Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients

Author

Ramspek, Chava L., primary, Boekee, Rosemarijn, additional, Evans, Marie, additional, Heimburger, Olof, additional, Snead, Charlotte M., additional, Caskey, Fergus J., additional, Torino, Claudia, additional, Porto, Gaetana, additional, Szymczak, Maciej, additional, Krajewska, Magdalena, additional, Drechsler, Christiane, additional, Wanner, Christoph, additional, Chesnaye, Nicholas C., additional, Jager, Kitty J., additional, Dekker, Friedo W., additional, Snoeijs, Maarten G.J., additional, Rotmans, Joris I., additional, van Diepen, Merel, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Musiała, Aleksandra, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Woodman, Alistair, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Jonsson, Andreas, additional, Schneider, Andreas, additional, Pignataro, Angelo, additional, Schrander, Anita, additional, Torp, Anke, additional, McKeever, Anna, additional, Szymczak, Anna, additional, Blom, Anna-Lena, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Ullah, Asad, additional, McLaren, Barbara, additional, van Dam, Bastiaan, additional, Iwig, Beate, additional, Antonio, Bellasi, additional, Di Iorio, Biagio Raffaele, additional, Rogland, Björn, additional, Perras, Boris, additional, Alessandra, Butti, additional, Harron, Camille, additional, Wallquist, Carin, additional, Siegert, Carl, additional, Barrett, Carla, additional, Gaillard, Carlo, additional, Garofalo, Carlo, additional, Abaterusso, Cataldo, additional, Beerenhout, Charles, additional, O'Toole, Charlotte, additional, Somma, Chiara, additional, Marx, Christian, additional, Summersgill, Christina, additional, Blaser, Christof, additional, D'alessandro, Claudia, additional, Emde, Claudia, additional, Zullo, Claudia, additional, Pozzi, Claudio, additional, Geddes, Colin, additional, Verburgh, Cornelis, additional, Bergamo, Daniela, additional, Ciurlino, Daniele, additional, Motta, Daria, additional, Glowski, Deborah, additional, McGlynn, Deborah, additional, Vargas, Denes, additional, Krieter, Detlef, additional, Russo, Domenico, additional, Fuchs, Dunja, additional, Sands, Dympna, additional, Hoogeveen, Ellen, additional, Irmler, Ellen, additional, Dimény, Emöke, additional, Favaro, Enrico, additional, Platen, Eva, additional, Olczyk, Ewelina, additional, Hoorn, Ewout, additional, Vigotti, Federica, additional, Ansali, Ferruccio, additional, Conte, Ferruccio, additional, Cianciotta, Francesca, additional, Giacchino, Francesca, additional, Cappellaio, Francesco, additional, Pizzarelli, Francesco, additional, Sundelin, Fredrik, additional, Uhlin, Fredrik, additional, Greco, Gaetano, additional, Roy, Geena, additional, Bigatti, Giada, additional, Marinangeli, Giancarlo, additional, Cabiddu, Gianfranca, additional, Hirst, Gillian, additional, Fumagalli, Giordano, additional, Caloro, Giorgia, additional, Piccoli, Giorgina, additional, Capasso, Giovanbattista, additional, Gambaro, Giovanni, additional, Tognarelli, Giuliana, additional, Bonforte, Giuseppe, additional, Conte, Giuseppe, additional, Toscano, Giuseppe, additional, Del Rosso, Goffredo, additional, Welander, Gunilla, additional, Augustyniak-Bartosik, Hanna, additional, Boots, Hans, additional, Schmidt-Gürtler, Hans, additional, King, Hayley, additional, McNally, Helen, additional, Schlee, Hendrik, additional, Boom, Henk, additional, Naujoks, Holger, additional, Masri-Senghor, Houda, additional, Murtagh, Hugh, additional, Rayner, Hugh, additional, Miśkowiec-Wiśniewska, Ilona, additional, Schlee, Ines, additional, Capizzi, Irene, additional, Hernandez, Isabel Bascaran, additional, Baragetti, Ivano, additional, Manitius, Jacek, additional, Turner, Jane, additional, Eijgenraam, Jan-Willem, additional, Kooman, Jeroen, additional, Beige, Joachim, additional, Pondel, Joanna, additional, Wilcox, Joanne, additional, Berdeprado, Jocelyn, additional, Röthele, Jochen, additional, Wong, Jonathan, additional, Rotmans, Joris, additional, Banda, Joyce, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Jędrzejak, Kamila, additional, Nowańska, Katarzyna, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Jones, Kirsteen, additional, Anding-Rost, Kirsten, additional, Gröntoft, Knut-Christian, additional, Oldrizzi, Lamberto, additional, Haydock, Lesley, additional, Vogt, Liffert, additional, Wilkinson, Lily, additional, Gesualdo, Loreto, additional, Schramm, Lothar, additional, Biancone, Luigi, additional, Nowak, Łukasz, additional, Raasveld, Maarten, additional, Durlik, Magdalena, additional, Magnano, Manuela, additional, Vervloet, Marc, additional, Ricardi, Marco, additional, Carmody, Margaret, additional, Di Bari, Maria, additional, Laudato, Maria, additional, Sirico, Maria Luisa, additional, Stendahl, Maria, additional, Svensson, Maria, additional, Weetman, Maria, additional, van Buren, Marjolijn, additional, Joinson, Martin, additional, Ferraresi, Martina, additional, Dutton, Mary, additional, Matthews, Michael, additional, Provenzano, Michele, additional, Hopf, Monika, additional, Malaguti, Moreno, additional, Wuttke, Nadja, additional, Morgan, Neal, additional, Palmieri, Nicola, additional, Frischmuth, Nikolaus, additional, Bleakley, Nina, additional, Murrone, Paola, additional, Cockwell, Paul, additional, Leurs, Paul, additional, Roderick, Paul, additional, Voskamp, Pauline, additional, Kashioulis, Pavlos, additional, Ichtiaris, Pawlos, additional, Blankestijn, Peter, additional, Kirste, Petra, additional, Schulz, Petra, additional, Mason, Phil, additional, Kalra, Philip, additional, Cirillo, Pietro, additional, Dattolo, Pietro, additional, Acampora, Pina, additional, Sajith, Rincy, additional, Nigro, Rita, additional, Boero, Roberto, additional, Scarpioni, Roberto, additional, Sicoli, Rosa, additional, Malandra, Rosella, additional, Aign, Sabine, additional, Cäsar, Sabine, additional, van Esch, Sadie, additional, Chapman, Sally, additional, Biribauer, Sandra, additional, Navjee, Santee, additional, Crosbie, Sarah, additional, Brown, Sharon, additional, Tickle, Sheila, additional, Manan, Sherin, additional, Röser, Silke, additional, Savoldi, Silvana, additional, Bertoli, Silvio, additional, Borrelli, Silvio, additional, Boorsma, Siska, additional, Heidenreich, Stefan, additional, Melander, Stefan, additional, Maxia, Stefania, additional, Maffei, Stefano, additional, Mangano, Stefano, additional, Palm, Stephanie, additional, Konings, Stijn, additional, Mathavakkannan, Suresh, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Dorota, Szyszkowska, additional, Cicchetti, Teresa, additional, Nieszporek, Teresa, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Rappa, Tiziana, additional, Almquist, Tora, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Jensen, Ulrika, additional, Palazzo, Valentina, additional, De Simone, Walter, additional, Seeger, Wolfgang, additional, Kuan, Ying, additional, Heleniak, Zbigniew, additional, and Aydin, Zeynep, additional

Published
2022
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6. Symptom Burden before and after Dialysis Initiation in Older Patients

Author

de Rooij, Esther N.M., Meuleman, Yvette, de Fijter, Johan W., Jager, Kitty J., Chesnaye, Nicholas C., Evans, Marie, Caskey, Fergus J., Torino, Claudia, Porto, Gaetana, Szymczak, Maciej, Drechsler, Christiane, Wanner, Christoph, Dekker, Friedo W., Hoogeveen, Ellen K., Schneider, Andreas, Torp, Anke, Iwig, Beate, Perras, Boris, Marx, Christian, Drechsler, Christiane, Blaser, Christof, Wanner, Christoph, Emde, Claudia, Krieter, Detlef, Fuchs, Dunja, Irmler, Ellen, Platen, Eva, Schmidt-Gürtler, Hans, Schlee, Hendrik, Naujoks, Holger, Schlee, Ines, Cäsar, Sabine, Beige, Joachim, Röthele, Jochen, Mazur, Justyna, Hahn, Kai, Blouin, Katja, Neumeier, Katrin, Anding-Rost, Kirsten, Schramm, Lothar, Hopf, Monika, Wuttke, Nadja, Frischmuth, Nikolaus, Ichtiaris, Pawlos, Kirste, Petra, Schulz, Petra, Aign, Sabine, Biribauer, Sandra, Manan, Sherin, Röser, Silke, Heidenreich, Stefan, Palm, Stephanie, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Stövesand, Torsten, Bahner, Udo, Seeger, Wolfgang, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Ranghino, Andrea, Stucchi, Andrea, Pignataro, Angelo, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Alessandra, Butti, Abaterusso, Cataldo, Somma, Chiara, D’alessandro, Claudia, Torino, Claudia, Zullo, Claudia, Pozzi, Claudio, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Russo, Domenico, Favaro, Enrico, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Greco, Gaetano, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Capizzi, Irene, Baragetti, Ivano, Oldrizzi, Lamberto, Gesualdo, Loreto, Biancone, Luigi, Magnano, Manuela, Ricardi, Marco, Di Bari, Maria, Laudato, Maria, Sirico, Maria Luisa, Ferraresi, Martina, Provenzano, Michele, Malaguti, Moreno, Palmieri, Nicola, Murrone, Paola, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Cicchetti, Teresa, Rappa, Tiziana, Palazzo, Valentina, De Simone, Walter, Schrander, Anita, van Dam, Bastiaan, Siegert, Carl, Gaillard, Carlo, Beerenhout, Charles, Verburgh, Cornelis, Janmaat, Cynthia, Hoogeveen, Ellen, Hoorn, Ewout, Dekker, Friedo, Boots, Johannes, Boom, Henk, Eijgenraam, Jan-Willem, Kooman, Jeroen, Rotmans, Joris, Jager, Kitty, Vogt, Liffert, Raasveld, Maarten, Vervloet, Marc, van Buren, Marjolijn, van Diepen, Merel, Chesnaye, Nicholas, Leurs, Paul, Voskamp, Pauline, Blankestijn, Peter, van Esch, Sadie, Boorsma, Siska, Berger, Stefan, Konings, Constantijn, Aydin, Zeynep, Musiała, Aleksandra, Szymczak, Anna, Olczyk, Ewelina, Augustyniak-Bartosik, Hanna, Miśkowiec-Wiśniewska, Ilona, Manitius, Jacek, Pondel, Joanna, Jędrzejak, Kamila, Nowańska, Katarzyna, Nowak, Łukasz, Szymczak, Maciej, Durlik, Magdalena, Dorota, Szyszkowska, Nieszporek, Teresa, Heleniak, Zbigniew, Jonsson, Andreas, Blom, Anna-Lena, Rogland, Björn, Wallquist, Carin, Vargas, Denes, Dimény, Emöke, Sundelin, Fredrik, Uhlin, Fredrik, Welander, Gunilla, Hernandez, Isabel Bascaran, Gröntoft, Knut-Christian, Stendahl, Maria, Svensson, Maria, Evans, Marie, Heimburger, Olof, Kashioulis, Pavlos, Melander, Stefan, Almquist, Tora, Jensen, Ulrika, Woodman, Alistair, McKeever, Anna, Ullah, Asad, McLaren, Barbara, Harron, Camille, Barrett, Carla, O'Toole, Charlotte, Summersgill, Christina, Geddes, Colin, Glowski, Deborah, McGlynn, Deborah, Sands, Dympna, Caskey, Fergus, Roy, Geena, Hirst, Gillian, King, Hayley, McNally, Helen, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Turner, Jane, Wilcox, Joanne, Berdeprado, Jocelyn, Wong, Jonathan, Banda, Joyce, Jones, Kirsteen, Haydock, Lesley, Wilkinson, Lily, Carmody, Margaret, Weetman, Maria, Joinson, Martin, Dutton, Mary, Matthews, Michael, Morgan, Neal, Bleakley, Nina, Cockwell, Paul, Roderick, Paul, Mason, Phil, Kalra, Philip, Sajith, Rincy, Chapman, Sally, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Mathavakkannan, Suresh, and Kuan, Ying

Published
2022
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8. Association Between Renal Function and Troponin T Over Time in Stable Chronic Kidney Disease Patients

Author

Chesnaye, Nicholas C., primary, Szummer, Karolina, additional, Bárány, Peter, additional, Heimbürger, Olof, additional, Magin, Hasan, additional, Almquist, Tora, additional, Uhlin, Fredrik, additional, Dekker, Friedo W., additional, Wanner, Christoph, additional, Jager, Kitty J, additional, Evans, Marie, additional, Cupisti, Adamasco, additional, Sagliocca, Adelia, additional, Ferraro, Alberto, additional, Musiała, Aleksandra, additional, Mele, Alessandra, additional, Naticchia, Alessandro, additional, Còsaro, Alex, additional, Woodman, Alistair, additional, Ranghino, Andrea, additional, Stucchi, Andrea, additional, Jonsson, Andreas, additional, Schneider, Andreas, additional, Pignataro, Angelo, additional, Schrander, Anita, additional, Torp, Anke, additional, McKeever, Anna, additional, Szymczak, Anna, additional, Blom, Anna‐Lena, additional, De Blasio, Antonella, additional, Pani, Antonello, additional, Tsalouichos, Aris, additional, Ullah, Asad, additional, McLaren, Barbara, additional, van Dam, Bastiaan, additional, Iwig, Beate, additional, Antonio, Bellasi, additional, Iorio, Biagio Raffaele Di, additional, Rogland, Björn, additional, Perras, Boris, additional, Alessandra, Butti, additional, Harron, Camille, additional, Wallquist, Carin, additional, Siegert, Carl, additional, Barrett, Carla, additional, Gaillard, Carlo, additional, Abaterusso, Cataldo, additional, Beerenhout, Charles, additional, O'Toole, Charlotte, additional, Somma, Chiara, additional, Marx, Christian, additional, Drechsler, Christiane, additional, Summersgill, Christina, additional, Blaser, Christof, additional, D'alessandro, Claudia, additional, Emde, Claudia, additional, Torino, Claudia, additional, Zullo, Claudia, additional, Pozzi, Claudio, additional, Geddes, Colin, additional, Verburgh, Cornelis, additional, Janmaat, Cynthia, additional, Bergamo, Daniela, additional, Ciurlino, Daniele, additional, Motta, Daria, additional, Glowski, Deborah, additional, McGlynn, Deborah, additional, Vargas, Denes, additional, Krieter, Detlef, additional, Russo, Domenico, additional, Fuchs, Dunja, additional, Sands, Dympna, additional, Hoogeveen, Ellen, additional, Irmler, Ellen, additional, Dimény, Emöke, additional, Favaro, Enrico, additional, Platen, Eva, additional, Olczyk, Ewelina, additional, Hoorn, Ewout, additional, Vigotti, Federica, additional, Caskey, Fergus, additional, Ansali, Ferruccio, additional, Conte, Ferruccio, additional, Cianciotta, Francesca, additional, Giacchino, Francesca, additional, Cappellaio, Francesco, additional, Pizzarelli, Francesco, additional, Sundelin, Fredrik, additional, Greco, Gaetano, additional, Roy, Geena, additional, Porto, Gaetana, additional, Bigatti, Giada, additional, Marinangeli, Giancarlo, additional, Cabiddu, Gianfranca, additional, Hirst, Gillian, additional, Fumagalli, Giordano, additional, Caloro, Giorgia, additional, Piccoli, Giorgina, additional, Capasso, Giovanbattista, additional, Gambaro, Giovanni, additional, Tognarelli, Giuliana, additional, Bonforte, Giuseppe, additional, Conte, Giuseppe, additional, Toscano, Giuseppe, additional, Rosso, Goffredo Del, additional, Welander, Gunilla, additional, Augustyniak‐Bartosik, Hanna, additional, Boots, Johannes, additional, Schmidt‐Gürtler, Hans, additional, King, Hayley, additional, McNally, Helen, additional, Schlee, Hendrik, additional, Boom, Henk, additional, Naujoks, Holger, additional, Masri‐Senghor, Houda, additional, Murtagh, Hugh, additional, Rayner, Hugh, additional, Miśkowiec‐Wiśniewska, Ilona, additional, Schlee, Ines, additional, Capizzi, Irene, additional, Cäsar, Sabine, additional, Hernandez, Isabel Bascaran, additional, Baragetti, Ivano, additional, Manitius, Jacek, additional, Turner, Jane, additional, Eijgenraam, Jan‐Willem, additional, Kooman, Jeroen, additional, Beige, Joachim, additional, Pondel, Joanna, additional, Wilcox, Joanne, additional, Berdeprado, Jocelyn, additional, Röthele, Jochen, additional, Wong, Jonathan, additional, Rotmans, Joris, additional, Banda, Joyce, additional, Mazur, Justyna, additional, Hahn, Kai, additional, Jędrzejak, Kamila, additional, Nowańska, Katarzyna, additional, Blouin, Katja, additional, Neumeier, Katrin, additional, Jones, Kirsteen, additional, Anding‐Rost, Kirsten, additional, Gröntoft, Knut‐Christian, additional, Oldrizzi, Lamberto, additional, Haydock, Lesley, additional, Vogt, Liffert, additional, Wilkinson, Lily, additional, Gesualdo, Loreto, additional, Schramm, Lothar, additional, Biancone, Luigi, additional, Nowak, Łukasz, additional, Raasveld, Maarten, additional, Szymczak, Maciej, additional, Durlik, Magdalena, additional, Magnano, Manuela, additional, Vervloet, Marc, additional, Ricardi, Marco, additional, Carmody, Margaret, additional, Di Bari, Maria, additional, Laudato, Maria, additional, Sirico, Maria Luisa, additional, Stendahl, Maria, additional, Svensson, Maria, additional, Weetman, Maria, additional, van Buren, Marjolijn, additional, Joinson, Martin, additional, Ferraresi, Martina, additional, Dutton, Mary, additional, Postorino, Maurizio, additional, van Diepen, Merel, additional, Matthews, Michael, additional, Provenzano, Michele, additional, Hopf, Monika, additional, Malaguti, Moreno, additional, Wuttke, Nadja, additional, Morgan, Neal, additional, Palmieri, Nicola, additional, Frischmuth, Nikolaus, additional, Bleakley, Nina, additional, Murrone, Paola, additional, Cockwell, Paul, additional, Leurs, Paul, additional, Roderick, Paul, additional, Voskamp, Pauline, additional, Kashioulis, Pavlos, additional, Ichtiaris, Pawlos, additional, Blankestijn, Peter, additional, Kirste, Petra, additional, Schulz, Petra, additional, Mason, Phil, additional, Kalra, Philip, additional, Cirillo, Pietro, additional, Dattolo, Pietro, additional, Acampora, Pina, additional, Sajith, Rincy, additional, Nigro, Rita, additional, Boero, Roberto, additional, Scarpioni, Roberto, additional, Sicoli, Rosa, additional, Malandra, Rosella, additional, Aign, Sabine, additional, van Esch, Sadie, additional, Chapman, Sally, additional, Biribauer, Sandra, additional, Navjee, Santee, additional, Crosbie, Sarah, additional, Brown, Sharon, additional, Tickle, Sheila, additional, Manan, Sherin, additional, Röser, Silke, additional, Savoldi, Silvana, additional, Bertoli, Silvio, additional, Borrelli, Silvio, additional, Boorsma, Siska, additional, Heidenreich, Stefan, additional, Melander, Stefan, additional, Maxia, Stefania, additional, Maffei, Stefano, additional, Mangano, Stefano, additional, Palm, Stephanie, additional, Konings, Constantijn, additional, Mathavakkannan, Suresh, additional, Schwedler, Susanne, additional, Delrieux, Sylke, additional, Renker, Sylvia, additional, Schättel, Sylvia, additional, Dorota, Szyszkowska, additional, Cicchetti, Teresa, additional, Nieszporek, Teresa, additional, Stephan, Theresa, additional, Schmiedeke, Thomas, additional, Weinreich, Thomas, additional, Leimbach, Til, additional, Rappa, Tiziana, additional, Stövesand, Torsten, additional, Bahner, Udo, additional, Jensen, Ulrika, additional, Palazzo, Valentina, additional, De Simone, Walter, additional, Seeger, Wolfgang, additional, Kuan, Ying, additional, Heleniak, Zbigniew, additional, and Aydin, Zeynep, additional

Published
2019
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10. Autosomal dominant polycystic kidney disease in absence of renal cyst formation illustrates genetic interaction between WT1 and PKD1.

Author

Münch, Johannes, Kirschner, Karin M., Schlee, Hendrik, Kraus, Cornelia, Schönauer, Ria, Wenjun Jin, Le Duc, Diana, Scholz, Holger, and Halbritter, Jan

Abstract

Purpose Autosomal dominant polycystic kidney disease (ADPKD), caused by pathogenic variants of either PKD1 or PKD2, is characterised by wide interfamilial and intrafamilial phenotypic variability. This study aimed to determine the molecular basis of marked clinical variability in ADPKD family members and sought to analyse whether alterations of WT1 (Wilms tumour 1), encoding a regulator of gene expression, may have an impact on renal cyst formation. Methods ADPKD family members underwent clinical and molecular evaluation. Functionally, Pkd1 mRNA and protein expression upon Wt1 knockdown was evaluated in mouse embryonic kidneys and mesonephric M15 cells. Results By renal gene panel analysis, we identified two pathogenic variants in an individual with maternal history of ADPKD, however, without cystic kidneys but polycystic liver disease: a known PKD1 missense variant (c.8311G>A, p.Glu2771Lys) and a known de novo WT1 splice site variant (c.1432+4C>T). The latter was previously associated with imbalanced +/-KTS isoform ratio of WT1. In ex vivo organ cultures from mouse embryonic kidneys, Wt1 knockdown resulted in decreased Pkd1 expression on mRNA and protein level. Conclusion While the role of WT1 in glomerulopathies has been well established, this report by illustrating genetic interaction with PKD1 proposes WT1 as potential modifier in ADPKD. [ABSTRACT FROM AUTHOR]

Published
2021
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12. Kidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD

Author

Ramspek, Chava L., Evans, Marie, Wanner, Christoph, Drechsler, Christiane, Chesnaye, Nicholas C., Szymczak, Maciej, Krajewska, Magdalena, Torino, Claudia, Porto, Gaetana, Hayward, Samantha, Caskey, Fergus, Dekker, Friedo W., Jager, Kitty J., van Diepen, Merel, Cupisti, Adamasco, Sagliocca, Adelia, Ferraro, Alberto, Musiała, Aleksandra, Mele, Alessandra, Naticchia, Alessandro, Còsaro, Alex, Woodman, Alistair, Ranghino, Andrea, Stucchi, Andrea, Jonsson, Andreas, Schneider, Andreas, Pignataro, Angelo, Schrander, Anita, Torp, Anke, McKeever, Anna, Szymczak, Anna, Blom, Anna-Lena, De Blasio, Antonella, Pani, Antonello, Tsalouichos, Aris, Ullah, Asad, McLaren, Barbara, van Dam, Bastiaan, Iwig, Beate, Antonio, Bellasi, Di Iorio, Biagio Raffaele, Rogland, Björn, Perras, Boris, Alessandra, Butti, Harron, Camille, Wallquist, Carin, Siegert, Carl, Barrett, Carla, Gaillard, Carlo, Garofalo, Carlo, Abaterusso, Cataldo, Beerenhout, Charles, O’Toole, Charlotte, Somma, Chiara, Marx, Christian, Summersgill, Christina, Blaser, Christof, D’alessandro, Claudia, Emde, Claudia, Zullo, Claudia, Pozzi, Claudio, Geddes, Colin, Verburgh, Cornelis, Bergamo, Daniela, Ciurlino, Daniele, Motta, Daria, Glowski, Deborah, McGlynn, Deborah, Vargas, Denes, Krieter, Detlef, Russo, Domenico, Fuchs, Dunja, Sands, Dympna, Hoogeveen, Ellen, Irmler, Ellen, Dimény, Emöke, Favaro, Enrico, Platen, Eva, Olczyk, Ewelina, Hoorn, Ewout, Vigotti, Federica, Ansali, Ferruccio, Conte, Ferruccio, Cianciotta, Francesca, Giacchino, Francesca, Cappellaio, Francesco, Pizzarelli, Francesco, Sundelin, Fredrik, Uhlin, Fredrik, Greco, Gaetano, Roy, Geena, Porto, Gaetana, Bigatti, Giada, Marinangeli, Giancarlo, Cabiddu, Gianfranca, Hirst, Gillian, Fumagalli, Giordano, Caloro, Giorgia, Piccoli, Giorgina, Capasso, Giovanbattista, Gambaro, Giovanni, Tognarelli, Giuliana, Bonforte, Giuseppe, Conte, Giuseppe, Toscano, Giuseppe, Del Rosso, Goffredo, Welander, Gunilla, Augustyniak-Bartosik, Hanna, Boots, Hans, Schmidt-Gürtler, Hans, King, Hayley, McNally, Helen, Schlee, Hendrik, Boom, Henk, Naujoks, Holger, Masri-Senghor, Houda, Murtagh, Hugh, Rayner, Hugh, Miśkowiec-Wiśniewska, Ilona, Schlee, Ines, Capizzi, Irene, Bascaran Hernandez, Isabel, Baragetti, Ivano, Manitius, Jacek, Turner, Jane, Eijgenraam, Jan-Willem, Kooman, Jeroen, Beige, Joachim, Pondel, Joanna, Wilcox, Joanne, Berdeprado, Jocelyn, Röthele, Jochen, Wong, Jonathan, Rotmans, Joris, Banda, Joyce, Mazur, Justyna, Hahn, Kai, Jędrzejak, Kamila, Nowańska, Katarzyna, Blouin, Katja, Neumeier, Katrin, Jones, Kirsteen, Anding-Rost, Kirsten, Gröntoft, Knut-Christian, Oldrizzi, Lamberto, Haydock, Lesley, Vogt, Liffert, Wilkinson, Lily, Gesualdo, Loreto, Schramm, Lothar, Biancone, Luigi, Nowak, Łukasz, Raasveld, Maarten, Durlik, Magdalena, Magnano, Manuela, Vervloet, Marc, Ricardi, Marco, Carmody, Margaret, Di Bari, Maria, Laudato, Maria, Luisa Sirico, Maria, Stendahl, Maria, Svensson, Maria, Weetman, Maria, van Buren, Marjolijn, Joinson, Martin, Ferraresi, Martina, Dutton, Mary, van Diepen, Merel, Matthews, Michael, Provenzano, Michele, Hopf, Monika, Malaguti, Moreno, Wuttke, Nadja, Morgan, Neal, Palmieri, Nicola, Frischmuth, Nikolaus, Bleakley, Nina, Murrone, Paola, Cockwell, Paul, Leurs, Paul, Roderick, Paul, Voskamp, Pauline, Kashioulis, Pavlos, Ichtiaris, Pawlos, Blankestijn, Peter, Kirste, Petra, Schulz, Petra, Mason, Phil, Kalra, Philip, Cirillo, Pietro, Dattolo, Pietro, Acampora, Pina, Sajith, Rincy, Nigro, Rita, Boero, Roberto, Scarpioni, Roberto, Sicoli, Rosa, Malandra, Rosella, Aign, Sabine, Cäsar, Sabine, van Esch, Sadie, Chapman, Sally, Biribauer, Sandra, Navjee, Santee, Crosbie, Sarah, Brown, Sharon, Tickle, Sheila, Manan, Sherin, Röser, Silke, Savoldi, Silvana, Bertoli, Silvio, Borrelli, Silvio, Boorsma, Siska, Heidenreich, Stefan, Melander, Stefan, Maxia, Stefania, Maffei, Stefano, Mangano, Stefano, Palm, Stephanie, Konings, Stijn, Mathavakkannan, Suresh, Schwedler, Susanne, Delrieux, Sylke, Renker, Sylvia, Schättel, Sylvia, Dorota, Szyszkowska, Cicchetti, Teresa, Nieszporek, Teresa, Stephan, Theresa, Schmiedeke, Thomas, Weinreich, Thomas, Leimbach, Til, Rappa, Tiziana, Almquist, Tora, Stövesand, Torsten, Bahner, Udo, Jensen, Ulrika, Palazzo, Valentina, De Simone, Walter, Seeger, Wolfgang, Kuan, Ying, Heleniak, Zbigniew, and Aydin, Zeynep

Published
2021
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13. Autosomal dominant polycystic kidney disease in absence of renal cyst formation illustrates genetic interaction between WT1and PKD1

Author

Mu¨nch, Johannes, Kirschner, Karin M, Schlee, Hendrik, Kraus, Cornelia, Scho¨nauer, Ria, Jin, Wenjun, Le Duc, Diana, Scholz, Holger, and Halbritter, Jan

Abstract

PurposeAutosomal dominant polycystic kidney disease (ADPKD), caused by pathogenic variants of either PKD1or PKD2, is characterised by wide interfamilial and intrafamilial phenotypic variability. This study aimed to determine the molecular basis of marked clinical variability in ADPKD family members and sought to analyse whether alterations of WT1(Wilms tumour 1), encoding a regulator of gene expression, may have an impact on renal cyst formation.MethodsADPKD family members underwent clinical and molecular evaluation. Functionally, Pkd1mRNA and protein expression upon Wt1knockdown was evaluated in mouse embryonic kidneys and mesonephric M15 cells.ResultsBy renal gene panel analysis, we identified two pathogenic variants in an individual with maternal history of ADPKD, however, without cystic kidneys but polycystic liver disease: a known PKD1missense variant (c.8311G>A, p.Glu2771Lys) and a known de novo WT1splice site variant (c.1432+4C>T). The latter was previously associated with imbalanced +/−KTS isoform ratio of WT1. In ex vivo organ cultures from mouse embryonic kidneys, Wt1knockdown resulted in decreased Pkd1expression on mRNA and protein level.ConclusionWhile the role of WT1 in glomerulopathies has been well established, this report by illustrating genetic interaction with PKD1proposes WT1as potential modifier in ADPKD.

Published
2021
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