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166 results on '"Schmeding, M."'

1. Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

Author

Roeth AA, Slabu I, Baumann M, Alizai PH, Schmeding M, Guentherodt G, Schmitz-Rode T, and Neumann UP

Subjects
Drug targeting, magnetic nanoparticles, SPION, prostate cancer, esophageal cancer, Medicine (General), R5-920
Abstract

Anjali A Roeth,1,* Ioana Slabu,2,* Martin Baumann,2 Patrick H Alizai,1 Maximilian Schmeding,1 Gernot Guentherodt,3 Thomas Schmitz-Rode,2 Ulf P Neumann1 1Department of General, Visceral and Transplant Surgery, University Hospital RWTH Aachen, 2Institute of Applied Medical Engineering, Helmholtz-Institute Aachen, RWTH Aachen, Aachen, 3Institute of Physics A, RWTH Aachen University, Aachen, Germany *These authors contributed equally to this work Abstract: Superparamagnetic iron oxide nanoparticles (SPION) may be used for local tumor treatment by coupling them to a drug and accumulating them locally with magnetic field traps, that is, a combination of permanent magnets and coils. Thereafter, an alternating magnetic field generates heat which may be used to release the thermosensitively bound drug and for hyperthermia. Until today, only superficial tumors can be treated with this method. Our aim was to transfer this method into an endoscopic setting to also reach the majority of tumors located inside the body. To find the ideal endoscopic magnetic field trap, which accumulates the most SPION, we first developed a biophysical model considering anatomical as well as physical conditions. Entities of choice were esophageal and prostate cancer. The magnetic susceptibilities of different porcine and rat tissues were measured with a superconducting quantum interference device. All tissues showed diamagnetic behavior. The evaluation of clinical data (computed tomography scan, endosonography, surgical reports, pathological evaluation) of patients gave insight into the topographical relationship between the tumor and its surroundings. Both were used to establish the biophysical model of the tumors and their surroundings, closely mirroring the clinical situation, in which we could virtually design, place and evaluate different electromagnetic coil configurations to find optimized magnetic field traps for each tumor entity. By simulation, we could show that the efficiency of the magnetic field traps can be enhanced by 38-fold for prostate and 8-fold for esophageal cancer. Therefore, our approach of endoscopic targeting is an improvement of the magnetic drug-targeting setups for SPION tumor therapy as it holds the possibility of reaching tumors inside the body in a minimal-invasive way. Future animal experiments must prove these findings in vivo. Keywords: drug targeting, simulation, SPION, prostate cancer, esophageal cancer

Published
2017

2. Lebendspende-Lebertransplantation beim Erwachsenen

Author

Neumann, U.P., Neuhaus, P., and Schmeding, M.

Abstract

Zusammenfassung: Vor dem Hintergrund des weltweit bestehenden Spendermangels bietet die Lebendspende-Lebertransplantation eine wertvolle Therapiealternative zur Leichenspende. Neben der chirurgisch-technischen Komplexität des Verfahrens stellt die adäquate Auswahl der geeigneten Spender und Empfänger die größte Herausforderung dar. Die Spendersicherheit ist oberste Prämisse, der alle weiteren Entscheidungen untergeordnet werden müssen. Den in Europa und Nordamerika seit einigen Jahren leicht rückläufigen Lebendspendezahlen stehen sehr erfolgreiche und expandierende Lebendspendeprogramme im asiatischen Raum gegenüber. Die zunehmende Erfahrung hat gezeigt, dass insbesondere technische Aspekte der Gallengangsanastomose sowie des venösen Abstroms aus dem Teiltransplantat eine entscheidende Rolle für das Empfänger-Outcome spielen. So zeigt sich im Vergleich zur Leichenspende zwar eine erhöhte früh-postoperative Morbidität, das langfristige Organ- und Patientenüberleben ist jedoch dem der Kadaverspende mindestens ebenbürtig. Insbesondere für Patienten, die unter den Bedingungen des MELD-Allokationssystems sehr lange auf eine Leichenspende warten müssen, stellt die Leberlebendtransplantation eine geeignete Therapieoption dar. Eine Ausweitung der sog. „Milan-Kriterien“ für HCC-Patienten mit Lebendspendeoption wird derzeit kontrovers diskutiert.

Published
2024
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4. Erkrankungen der Leber

Author

R., Margreiter, R., Schlumpf, Schmeding, M., J., Wydler, Siewert, Jörg Rüdiger, editor, Rothmund, Matthias, editor, and Schumpelick, Volker, editor

Published
2011
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5. Portale Hypertension

Author

Bauer, J., Clavien, P.-A., Dutkowski, P., Gantert, W.A., Lurje, G., Müllhaupt, B., Renner, E.L., Schmeding, M., Selzner, M., von Flüe, M., Sieber, C., Siewert, Jörg Rüdiger, editor, Rothmund, Matthias, editor, and Schumpelick, Volker, editor

Published
2011
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9. Erythropoietin reduziert den Ischämie-Reperfusionsschaden und verbessert das Überleben nach Fettleber-Transplantation im Rattenmodell

Author

Schmeding, M., Rademacher, S., Hunold, G., Boas-Knoop, S., Lippert, S., Neuhaus, P., Neumann, U., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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18. Liver Transplantation and Donor Body Mass Index >30 – Use or Refuse?

Author

Andert, A, Becker, N, Ulmer, F, Schöning, W, Hein, M, Neumann, UP, and Schmeding, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Background: Organ shortage is a major problem in liver transplantation. The use of extended criteria donors has become the most important strategy for increasing the donor pool. However, the role of donor body mass index has not yet been thoroughly investigated. The aim of our study was to compare outcomes[for full text, please go to the a.m. URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
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19. Postoperatives Leberversagen nach vorheriger Pfortaderembolisation – eine multivariate Analyse unter Berücksichtigung von Restlebervolumen und Leberfunktionskapazität

Author

Alizai, PH, Haelsig, A, Roeth, A, Ulmer, F, Kienlein, S, Bruners, P, Neumann, UP, and Schmeding, M

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Pfortaderembolisation führt zu einer Größenzunahme des Restlebervolumens, dennoch kann es bei ausgedehnten Leberresektionen zu einem postoperativen Leberversagen kommen. Ziel dieser Studie ist es, präoperative Faktoren zu identifizieren, die zu einem postoperativen[zum vollständigen Text gelangen Sie über die oben angegebene URL], 133. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2016
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20. Randomized clinical trial of open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery after surgery programme (ORANGE II study)

Author

Wong-Lun-Hing, E M, primary, van Dam, R M, additional, van Breukelen, G J P, additional, Tanis, P J, additional, Ratti, F, additional, van Hillegersberg, R, additional, Slooter, G D, additional, de Wilt, J H W, additional, Liem, M S L, additional, de Boer, M T, additional, Klaase, J M, additional, Neumann, U P, additional, Aldrighetti, L A, additional, Dejong, C H C, additional, Terkivatan, T, additional, Verhoef, C, additional, Porte, R J, additional, Haverman, J W, additional, Busch, O R, additional, Boermeester, M A, additional, Besselink, M G, additional, Molenaar, I Q, additional, Borel Rinkes, I H M, additional, Bosscha, K, additional, van der Vorst, J R, additional, de Waard, J W D, additional, Gerhards, M F, additional, Patijn, G A, additional, Schmeding, M, additional, Primrose, J N, additional, Abu Hilal, M, additional, Dagher, I, additional, Laurent, A, additional, Topal, B, additional, Edwin, B, additional, Lassen, K, additional, van Duyn, E B, additional, Ambergen, A W, additional, Olde Damink, S W, additional, and Bemelmans, M H, additional

Published
2017
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22. Sarcopenia, obesity and sarcopenic obesity: effects on liver function and volume in patients scheduled for major liver resection

Author

Lodewick, T.M., Roeth, A.A., Damink, S.W., Alizai, P.H., van Dam, R.M., Gassler, N., Schneider, M., Dello, S.A., Schmeding, M., Dejong, C.H., Neumann, U. P., RS: NUTRIM - R2 - Gut-liver homeostasis, and Surgery

Subjects
Sarcopenia, HEPATECTOMY, HEPATIC RESECTION, Liver function, DISEASE, DYSFUNCTION, COLORECTAL-CANCER, PREVALENCE, LiMAx, BODY-MASS INDEX, Volumetry, DEFINITION, HEPATOCELLULAR-CARCINOMA, L3 skeletal muscle index, RISK-FACTORS, Body fat percentage, Obesity
Abstract

BACKGROUND: Sarcopenia, obesity and sarcopenic obesity have been linked to impaired outcome after liver surgery. Preoperative liver function of sarcopenic, obese and sarcopenic-obese patients might be reduced, possibly leading to more post-operative morbidity. The aim of this study was to explore whether liver function and volume were influenced by body composition in patients undergoing liver resection. METHODS: In 2011 and 2012, all consecutive patients undergoing the methacetin breath liver function test were included. Liver volumetry and muscle mass analysis were performed using preoperative CT scans and Osirix((R)) software. Muscle mass and body-fat% were calculated. Predefined cut-off values for sarcopenia and the top two body-fat% quintiles were used to identify sarcopenia and obesity, respectively. Histologic assessment of the resected liver gave insight in background liver disease. RESULTS: A total number of 80 patients were included. Liver function and volume were comparable in sarcopenic(-obese) and non-sarcopenic(-obese) patients. Obese patients showed significantly reduced liver function [295 (95-508) vs. 358 (96-684) microg/kg/h, P = 0.018] and a trend towards larger liver size [1694 (1116-2685) vs. 1533 (869-2852) mL, P = 0.079] compared with non-obese patients. Weight (r = -0.40), body surface area (r = -0.32), estimated body-fat% (r = -0.43) and body mass index (r = -0.47) showed a weak but significant negative (all P < 0.05) correlation with liver function. Moreover, body-fat% was identified as an independent factor negatively affecting the liver function. CONCLUSION: Sarcopenia and sarcopenic obesity did not seem to influence liver size and function negatively. However, obese patients had larger, although less functional, livers, indicating dissociation of liver function and volume in these patients.

Published
2015

23. Lebertransplantation von einem chimären Spender nach Stammzelltransplantation bei einem Patienten mit Wiskott-Aldrich Syndrom

Author

Heise, D, Schmeding, M, Heidenhain, C, Trautwein, C, and Neumann, UP

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Eine etablierte Therapie des Wiskott-Aldrich Syndroms ist die allogene Stammzelltransplantation (SZT). Morbidität und Mortalität aufgrund von Organtoxizität nach SZT ist der wichtigste limitierende Faktor des Langzeitüberlebens. Bei terminalem Leberversagen aufgrund einer[for full text, please go to the a.m. URL], 132. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2015
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24. ALPPS nach erfolgloser PVE: ein sinnvolles Verfahren?

Author

Ulmer, TF, Heidenhain, C, Schmeding, M, Mossdorf, A, and Neumann, U

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die chirurgische Resektion ist unverändert die einzig kurative Therapieoption von primären oder sekundären Lebertumoren. Trotz der hohen Regenrationsfähigkeit der Leber sind dem Resektionsausmaß Grenzen gesetzt. Wird ein zu kleines Restvolumen der Leber (FLR) belassen,[for full text, please go to the a.m. URL], 131. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2014
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29. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II-trial): study protocol for a randomised controlled trial

Author

Van Dam, Ronald M., Wong-Lun-Hing, Edgar M., Van Breukelen, Gerard J. P., Stoot, Jan H. M. B., Van Der Vorst, Joost R., Bemelmans, Marc H. A., Olde Damink, Steven W. M., Lassen, Kristoffer, Dejong, Cornelis H. C., ORANGE II Study Group, Busch, O. R., Tanis, P. J., Hoekstra, L. T., Van Hillegersberg, R., Molenaar, I. Q., Verhoef, C., Terkivatan, T., De Jonge, J., Slooter, G. D., Roumen, R. M., Klaase, J. M., Van Duyn, E. B., Boscha, K., Porte, R. J., De Boer, M. T., Haveman, J. W., De Wilt, J. H., Buyne, O. R., Van Duijvendijk, P., Neumann, U., Schmeding, M., Ferla, G., Aldrighetti, L. A., Ferla, F., Primrose, J. N., Abu Hilal, M., Pearce, N. W., Dagher, I., Laurent, A., Topal, B., Troisi, R. I., Edwin, B., Boermeester, M. A., Borel Rinkes, I. H., Ambergen, A. W., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Surgery, AII - Amsterdam institute for Infection and Immunity, RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R2 - Gut-liver homeostasis, RS: FPN M&S I, FHML Methodologie & Statistiek, Dean and Directors Office, van Dam Ronald, M., Wong-Lun-Hing Edgar, M., Van Breukelen Gerard, J. P., Stoot Jan, H. M. B., van der Vorst Joost, R., Bemelmans Marc, H. A., Damink Steven W. M., Olde, Lassen, Kristoffer, Dejong Cornelis, H. C., and Aldrighetti, L

Subjects
Laparoscopic surgery, Time Factors, EARLY AMBULATION, medicine.medical_treatment, Medicine (miscellaneous), law.invention, Study Protocol, Quality of life, Randomized controlled trial, QUALITY-OF-LIFE, law, Left lateral sectionectomy, Clinical endpoint, Outpatient clinic, INCISIONAL HERNIA, Pharmacology (medical), Prospective Studies, Registries, ERAS, Hospital Costs, Prospective cohort study, lcsh:R5-920, PARTIAL-HEPATECTOMY, Hernia, Abdominal, INTESTINAL RESECTION, Europe, Treatment Outcome, COLONIC RESECTION, Patient Satisfaction, Research Design, Evaluation of complex medical interventions Tissue engineering and pathology [NCEBP 2], lcsh:Medicine (General), CLINICAL-TRIALS, RCT, medicine.medical_specialty, CONTROLLED REHABILITATION, Quality of Care [ONCOL 4], Cicatrix, Double-Blind Method, Body Image, medicine, Humans, Hepatectomy, Hernia, Open liver resection, business.industry, Recovery of Function, Length of Stay, medicine.disease, Surgery, COLORECTAL LIVER METASTASES, Clinical trial, NUMERIC RATING-SCALE, Quality of Life, Laparoscopy, business
Abstract

Trials 13, 54 (2012). doi:10.1186/1745-6215-13-54, Published by BioMed Central, London

Published
2012

30. Charakterisierung der magnetischen Gewebeeigenschaften für das Pharmakotargeting mit systemisch applizierten magnetischen Nanopartikeln (MNP) beim Klatskin-Tumor und Ösophaguskarzinom

Author

Röth, A, Slabu, I, Baumann, M, Conze, J, Lynen Jansen, P, Schmeding, M, Güntherodt, G, and Neumann, U

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Durch gezielte, lokale Applikation von Pharmaka mit Hilfe systemisch applizierter magnetischer Nanopartikel (MNP) als Träger können insbesondere die zahlreichen Nebenwirkungen einer systemischen Chemotherapie auf den Gesamtorganismus reduziert werden. Dazu sollen die MNP mittels[for full text, please go to the a.m. URL], 128. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2011
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31. Erythropoietin reduziert den Ischämie-Repefusionsschaden und verbessert das Überleben nach Fettleber-Transplantation im Rattenmodell

Author

Schmeding, M, Rademacher, S, Hunpld, G, Boas-Knoop, S, Lippert, S, Neuhaus, P, and Neumann, U

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die Lebertransplantation (LTX) stellt aktuell die einzige kausal-therapeutische Option in der Behandlung der Leberzirrhose dar. Aufgrund der eingeschränkten Verfügbarkeit geeigneter Organe liegt die Sterblichkeit der Patienten auf der Warteliste zur LTX bei bis zu 40%. Eine[for full text, please go to the a.m. URL], 126. Kongress der Deutschen Gesellschaft für Chirurgie

Published
2009
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34. Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS(R) programme (ORANGE II-trial): study protocol for a randomised controlled trial

Author

van Dam, R.M., Wong-Lun-Hing, E.M., Breukelen, G.J van, Stoot, J.H., van der Vorst, J.R., Bemelmans, M.H.A., Olde Damink, S.W., Lassen, K., Dejong, C.H., Busch, O.R., Tanis, P.J., Hoekstra, L.T., Hillegersberg, R. van, Verhoef, C., Terkivatan, T., Jonge, J de, Slooter, G.D., Roumen, R.M., Klaase, J.M., Duyn, E.B. van, Boscha, K., Porte, R.J., Boer, M.T. De, Haveman, J.W., Wilt, J.H. de, Buyne, O.R., Duijvendijk, P. van, Neumann, U., Schmeding, M., et al., van Dam, R.M., Wong-Lun-Hing, E.M., Breukelen, G.J van, Stoot, J.H., van der Vorst, J.R., Bemelmans, M.H.A., Olde Damink, S.W., Lassen, K., Dejong, C.H., Busch, O.R., Tanis, P.J., Hoekstra, L.T., Hillegersberg, R. van, Verhoef, C., Terkivatan, T., Jonge, J de, Slooter, G.D., Roumen, R.M., Klaase, J.M., Duyn, E.B. van, Boscha, K., Porte, R.J., Boer, M.T. De, Haveman, J.W., Wilt, J.H. de, Buyne, O.R., Duijvendijk, P. van, Neumann, U., Schmeding, M., and et al.

Abstract

Contains fulltext : 108907.pdf (publisher's version ) (Open Access), BACKGROUND: The use of lLaparoscopic liver resection in terms of time to functional recovery, length of hospital stay (LOS), long-term abdominal wall hernias, costs and quality of life (QOL) has never been studied in a randomised controlled trial. Therefore, this is the subject of the international multicentre randomised controlled ORANGE II trial. METHODS: Patients eligible for left lateral sectionectomy (LLS) of the liver will be recruited and randomised at the outpatient clinic. All randomised patients will undergo surgery in the setting of an ERAS programme. The experimental design produces two randomised arms (open and laparoscopic LLS) and a prospective registry. The prospective registry will be based on patients that cannot be randomised because of the explicit treatment preference of the patient or surgeon, or because of ineligibility (not meeting the in- and exclusion criteria) for randomisation in this trial. Therefore, all non-randomised patients undergoing LLS will be approached to participate in the prospective registry, thereby allowing acquisition of an uninterrupted prospective series of patients. The primary endpoint of the ORANGE II trial is time to functional recovery. Secondary endpoints are postoperative LOS, percentage readmission, (liver-specific) morbidity, QOL, body image and cosmetic result, hospital and societal costs over 1 year, and long-term incidence of incisional hernias. It will be assumed that in patients undergoing laparoscopic LLS, length of hospital stay can be reduced by two days. A sample size of 55 patients in each randomisation arm has been calculated to detect a 2-day reduction in LOS (90% power and alpha = 0.05 (two-tailed)).The ORANGE II trial is a multicenter randomised controlled trial that will provide evidence on the merits of laparoscopic surgery in patients undergoing LLS within an enhanced recovery ERAS programme. TRIAL REGISTRATION: ClinicalTrials.gov NCT00874224.

Published
2012

50. Delayed formation of a devastating granulomatous process after metal-on-metal lumbar disc arthroplasty.

Author

Cabraja M, Schmeding M, Koch A, Podrabsky P, Kroppenstedt S, Cabraja, Mario, Schmeding, Maximilian, Koch, Arend, Podrabsky, Petr, and Kroppenstedt, Stefan

Abstract

Study Design: A case report. Objective: We report the case of a female patient with a delayed and devastating complication after lumbar total disc arthroplasty (TDA). Summary Of Background Data: The formation of granulomatous tissue surrounding arthroplasty devices has been described after hip replacements, but has been reported only in a few cases after spinal surgery. Methods: Retrospective case study of a female patient with a delayed complication after lumbar TDA with a metal-on-metal device for degenerative disc disease at level L4-L5 and with follow-up examination 8 months after surgery. Results: About 11 months after lumbar arthroplasty surgery, the patient developed back pain and progressive weakness of both legs. A computed tomographic scan revealed soft tissue surrounding the TDA device and infiltrating the spinal canal. The revision surgery (posterior fixation and decompression) did not improve the clinical situation. The progressive growth of soft tissue led to a high-grade paraparesis and occlusion of the left ureter as well as of both common iliac veins and the infrarenal part of the vena cava inferior. The TDA device was removed. Another posterior surgery with extensive instrumentation was necessary to treat the destruction of vertebral bodies L4 and L5 2 months after the last surgery. The histopathological analysis revealed a granulomatous necrotizing inflammation. After the last revision surgery, the patient's back pain decreased. At her last follow-up, no further growth of the soft tissue mass could be found. Conclusion: Metal-on-Metal TDA devices can induce a tumor-like growth with devastating consequences. The reduction of device motion by posterior stabilizing surgery does not seem to stop the growth of the granulomatous mass. The device has to be removed. [ABSTRACT FROM AUTHOR]

Published
2012
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