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5. Development, manufacturing and testing of small launcher structures from Portugal

Author

Guerra, André G. C., Alonso, Daniel, Silva, Catarina, Costa, Alexander, Rocha, Joaquim, Colaço, Luis, Fortuna, Sandra, Pires, Tiago, Pinheiro, Luis, Carneiro, Nuno, João, André, Araújo, Gonçalo, Meireles, Pedro, and Schmid, Stephan

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

During the last decades the industry has seen the number of Earth orbiting satellites rise, mostly due to the need to monitor Earth as well as to establish global communication networks. Nano, micro, and small satellites have been a prime tool for answering these needs, with large and mega constellations planned, leading to a potential launch gap. An effective and commercially appealing solution is the development of small launchers, as these can complement the current available launch opportunity offer, serving a large pool of different types of clients, with a flexible and custom service that large conventional launchers cannot adequately assure. Rocket Factory Augsburg has partnered with CEiiA for the development of several structures for the RFA One rocket. The objective has been the design of solutions that are low-cost, light, and custom-made, applying design and manufacturing concepts as well as technologies from other industries, like the aeronautical and automotive, to the aerospace one. This allows for the implementation of a New Space approach to the launcher segment, while also building a supply chain and a set of solutions that enables the industrialisation of such structures for this and future small launchers. The two main systems under development have been a versatile Kick-Stage, for payload carrying and orbit insertion, and a sturdy Payload Fairing. Even though the use of components off-the-shelf have been widely accepted in the space industry for satellites, these two systems pose different challenges as they must be: highly reliable during the most extreme conditions imposed by the launch, so that they can be considered safe to launch all types of payloads. This paper thus dives deep on the solutions developed in the last few years, presenting also lessons learned during the manufacturing and testing of these structures., Comment: 10 pages, 13 figures, Manuscript presented at the 73rd International Astronautical Congress, IAC 2022, Paris, France, 18 - 22 September 2022

Published
2022

7. Zur Vokalquantität in der Mundart der Stadt Zürich

Author

Schmid, Stephan

Subjects
Dialectology of Swiss German, Computational linguistics. Natural language processing, P98-98.5, Language. Linguistic theory. Comparative grammar, P101-410
Abstract

This paper analyses the vowel system of the dialect spoken in the city of Zürich, which shows a systematic use of distinctive length contrasts. In order to ascertain the acoustic correlates of the quantity feature, an experimental study has been done, during which three speakers produced a corpus of carefully designed read speech. The duration of 162 vowels and 162 consonants has been measured, as well as the first two formants of 54 high vowels.The results indicate duration as the only relevant correlate of vowel quantity in this dialect, with a mean V/V: ratio of 0.56. The duration of the following consonants does not vary significantly, nor are there any striking spectral differences between short and long high vowels. From a look at some intensity contours it appears that short vowels are not 'cut' - a finding in line with a recent areal typology of German dialects.

Published
2004

13. U-Shift II Vision and Project Goals

Author

Münster, Marco, Brost, Mascha, Siefkes, Tjark, Kopp, Gerhard, Beeh, Elmar, Rinderknecht, Frank, Schmid, Stephan, Osebek, Manuel, Scheibe, Sebastian, Hahn, Robert, Heyner, David, Klein, Philipp, Piazza, Giovanni, Ulrich, Christian, Kraft, Werner, Philipps, Franz, Köhler, Lennart, Buchholz, Michael, Wodtko, Thomas, Dietmayer, Klaus, Frey, Michael, Weitz, Fabian, Gauterin, Frank, Stoll, Hannes, Schindewolf, Marc, Guissouma, Houssem, Krauter, Felix, Sax, Eric, Neubeck, Jens, Müller, Sven, Eberts, Sven, Göldner, Michael, Teichmann, Stephan, Kiebler, Jochen, Saljanin, Miralem, Bargende, Michael, Wagner, Andreas, Bargende, Michael, editor, Reuss, Hans-Christian, editor, and Wagner, Andreas, editor

Published
2022
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15. Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis

Author

Fererberger, Tanja, primary, Buechler, Christa, additional, Kandulski, Arne, additional, Elger, Tanja, additional, Loibl, Johanna, additional, Schmid, Stephan, additional, Sommersberger, Stefanie, additional, Gunawan, Stefan, additional, Zundler, Sebastian, additional, Huss, Muriel, additional, Bettenworth, Dominik, additional, Kempa, Sally, additional, Weidlich, Simon, additional, Föh, Bandik, additional, Huang, Xinyu, additional, Grzegorzek, Marcin, additional, Derer-Petersen, Stefanie, additional, Günther, Ulrich L., additional, Marquardt, Jens U., additional, Kunst, Claudia, additional, Gülow, Karsten, additional, Müller, Martina, additional, Sina, Christian, additional, Schmelter, Franziska, additional, and Tews, Hauke C., additional

Published
2024
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16. TOP-346-YI Therapeutic plasma exchange in Amatoxin associated acute liver failure-results from an interim analysis of the Amanita-PEX study

Author

Stahl, Klaus, primary, Nalbant, Bahar, additional, Laue, Tobias, additional, Cardoso, Filipe Sousa, additional, Madaleno, Joao, additional, Stöckert, Petra, additional, Tegtmeyer, Daniel, additional, Di Giorgio, Angelo, additional, Große, Karsten, additional, Merle, Uta, additional, Mareljic, Nikola, additional, van de Loo, Dominik, additional, Toapanta, David, additional, Lenz, Dominic, additional, Fritz, Tanja, additional, Linke, Alexandra, additional, Bjerring, Peter Nissen, additional, Fierro-Angulo, Oscar M., additional, Macias Rodriguez, Ricardo Ulises, additional, Geerts, Anja, additional, Raevens, Sarah, additional, Sebode, Marcial, additional, Sterneck, Martina, additional, Sturm, Ekkehard, additional, Fichtner, Alexander, additional, Reverter, Enric, additional, Tepasse, Phil Robin, additional, Lange, Christian M., additional, Bruns, Tony, additional, Oh, Jun, additional, Schmid, Stephan, additional, Müller-Schilling, Martina, additional, Borges, Catarina, additional, Marques, Hugo Pinto, additional, Baumann, Ulrich, additional, Wedemeyer, Heiner, additional, and Taubert, Richard, additional

Published
2024
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17. Serum Adiponectin Predicts COVID-19 Severity

Author

Pavel, Vlad, primary, Räth, Ulrich, additional, Schmid, Stephan, additional, Krautbauer, Sabrina, additional, Keller, Dennis, additional, Amend, Pablo, additional, Müller, Martina, additional, Mester, Patricia, additional, and Buechler, Christa, additional

Published
2024
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18. Relationship between interprofessional collaboration and psychological distress experienced by healthcare professionals during COVID-19: a monocentric cross-sectional study

Author

Ruttmann, Kirstin, primary, Albaladejo-Fuertes, Sheila, additional, Lindenberg, Nicole, additional, Kunst, Claudia, additional, Mehrl, Alexander, additional, Kindl, Vera, additional, Gülow, Karsten, additional, Schlosser-Hupf, Sophie, additional, Schmid, Stephan, additional, and Müller, Martina, additional

Published
2024
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22. High Serum S100A12 as a Diagnostic and Prognostic Biomarker for Severity, Multidrug-Resistant Bacteria Superinfection and Herpes Simplex Virus Reactivation in COVID-19.

Author

Mester, Patricia, Keller, Dennis, Kunst, Claudia, Räth, Ulrich, Rusch, Sophia, Schmid, Stephan, Krautbauer, Sabrina, Müller, Martina, Buechler, Christa, and Pavel, Vlad

Subjects
COVID-19, VIRUS diseases, BACTERIAL diseases, HERPES simplex, ENZYME-linked immunosorbent assay, CALCITONIN
Abstract

Neutrophils are critical immune cells in severe coronavirus disease 2019 (COVID-19). S100 calcium-binding protein A12 (S100A12) is highly expressed in neutrophils during acute inflammation. The aim of this study was to evaluate serum S100A12 levels as a diagnostic and prognostic tool in COVID-19. Serum samples of patients with moderate and severe COVID-19 were collected during 2020 to 2024. Enzyme-linked immunosorbent assay was used to measure serum S100A12 levels in 63 patients with moderate COVID-19, 60 patients with severe disease and 33 healthy controls. Serum S100A12 levels were elevated in moderate COVID-19 compared to controls and were even higher in severe cases. In moderate disease, serum S100A12 levels positively correlated with immune cell counts. While C-reactive protein and procalcitonin are established inflammation markers, they did not correlate with serum S100A12 levels in either patient cohort. Patients with severe COVID-19 and vancomycin-resistant enterococcus (VRE) infection had increased S100A12 levels. Elevated S100A12 levels were also observed in patients with herpes simplex reactivation. Fungal superinfections did not alter S100A12 levels. These data show that serum S100A12 increases in moderate and severe COVID-19 and is further elevated by VRE bloodstream infection and herpes simplex reactivation. Therefore, S100A12 may serve as a novel biomarker for severe COVID-19 and an early diagnostic indicator for bacterial and viral infections. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Evaluating the impact of interprofessional training wards on patient satisfaction and clinical outcomes: a mixed-methods analysis

Author

Schlosser-Hupf, Sophie, primary, Aichner, Elisabeth, additional, Meier, Marcus, additional, Albaladejo-Fuertes, Sheila, additional, Ruttmann, Kirstin, additional, Rusch, Sophia, additional, Michels, Bernhard, additional, Mehrl, Alexander, additional, Kunst, Claudia, additional, Schmid, Stephan, additional, and Müller, Martina, additional

Published
2024
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28. A highly specific and sensitive serological assay detects SARS-CoV-2 antibody levels in COVID-19 patients that correlate with neutralization

Author

Peterhoff, David, Glück, Vivian, Vogel, Matthias, Schuster, Philipp, Schütz, Anja, Neubert, Philip, Albert, Veruschka, Frisch, Stefanie, Kiessling, Mara, Pervan, Philip, Werner, Maren, Ritter, Nicole, Babl, Leon, Deichner, Maria, Hanses, Frank, Lubnow, Matthias, Müller, Thomas, Lunz, Dirk, Hitzenbichler, Florian, Audebert, Franz, Hähnel, Viola, Offner, Robert, Müller, Martina, Schmid, Stephan, Burkhardt, Ralph, Glück, Thomas, Koller, Michael, Niller, Hans Helmut, Graf, Bernhard, Salzberger, Bernd, Wenzel, Jürgen J., Jantsch, Jonathan, Gessner, André, Schmidt, Barbara, and Wagner, Ralf

Published
2021
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29. Unraveling the Role of Reactive Oxygen Species in T Lymphocyte Signaling.

Author

Gülow, Karsten, Tümen, Deniz, Heumann, Philipp, Schmid, Stephan, Kandulski, Arne, Müller, Martina, and Kunst, Claudia

Subjects
T cells, NUCLEAR factor E2 related factor, REACTIVE oxygen species, MITOGEN-activated protein kinase kinase, NF-kappa B, NICOTINAMIDE adenine dinucleotide phosphate, ERYTHROCYTE membranes
Abstract

Reactive oxygen species (ROS) are central to inter- and intracellular signaling. Their localized and transient effects are due to their short half-life, especially when generated in controlled amounts. Upon T cell receptor (TCR) activation, regulated ROS signaling is primarily initiated by complexes I and III of the electron transport chain (ETC). Subsequent ROS production triggers the activation of nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2), prolonging the oxidative signal. This signal then engages kinase signaling cascades such as the mitogen-activated protein kinase (MAPK) pathway and increases the activity of REDOX-sensitive transcription factors such as nuclear factor-kappa B (NF-κB) and activator protein-1 (AP-1). To limit ROS overproduction and prevent oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) and antioxidant proteins such as superoxide dismutases (SODs) finely regulate signal intensity and are capable of terminating the oxidative signal when needed. Thus, oxidative signals, such as T cell activation, are well-controlled and critical for cellular communication. [ABSTRACT FROM AUTHOR]

Published
2024
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40. An A(oo)-structure on the cohomology ring of the symmetric group Sp with coefficients in Fp

Author

Schmid, Stephan

Subjects
Mathematics - Representation Theory, 18G15
Abstract

Let p be a prime. Let FpSp be the group algebra of the symmetric group over the finite field Fp with |Fp|=p$. Let Fp be the trivial FpSp-module. We present a projective resolution PRes Fp of the module Fp and equip the Yoneda algebra Ext(Fp,Fp) with an A(oo)-structure such that Ext(Fp,Fp) becomes a minimal model of the dg-algebra Hom(PRes Fp, PRes Fp).

Published
2013

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