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Purpose: To analyze the effect of different haptic angulations on posterior capsule opacification (PCO) in a modern foldable intraocular lens (IOL) with a square-edged optic designed to reduce the incidence of PCO.Setting: Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA.Methods: Ten Dutch Belted, serum Pasteurella-free pigmented rabbits of the same age and sex had bilateral phacoemulsification with endocapsular IOL implantation. The eyes were implanted with Centerflex® IOLs (Rayner) with haptic angulations of 0 degree (n = 8), 5 degrees (n = 4), 10 degrees (n = 4), or 15 degrees (n = 4).Results: There was no statistical difference in central PCO, peripheral PCO, and measured IOL decentration among the angulation groups.Conclusion: With the Centerflex IOL, haptic angulation did not seem to be a significant factor influencing PCO. It appears that the barrier effect of the IOL’s truncated, square-edged optic overrides the angulation factor in preventing PCO. [Copyright &y& Elsevier]

Purpose: To analyze the rates of and reasons for intraoperative explantation of foldable and rigid intraocular lenses (IOLs) to determine the complication profile of each IOL design.Setting: Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina, USA.Methods: The study comprised data analysis of foldable (n = 85) and rigid (n = 15) IOL specimens that were explanted immediately after primary implantation.Results: Eighty-five foldable intraoperative explants were accessioned. These comprised 14.5% of the 586 foldable IOL explants received between January 1988 and September 2000. There were 15 rigid poly(methyl methacrylate) (PMMA) intraoperative explants out of 2077 rigid explant specimens (0.7%). Fifty-one (60%) of the foldable IOLs requiring intraoperative explantation were the 1-piece silicone plate-haptic large-hole design, and 29 (34.1%) were the 3-piece silicone polyimide-haptic design. The most frequent reason for explantation of both designs was optic damage, 37.3% in the large-hole design and 55.2% in the polyimide design. Optic damage did not occur in rigid PMMA IOLs.Conclusion: Some foldable IOL designs have a higher risk of damage during surgical insertion than rigid designs. Two modern foldable IOLs, the silicone plate-haptic large-hole and the silicone polyimide-haptic, appear to be more prone to damage during folding, loading, and implantation than other IOLs. [Copyright &y& Elsevier]

The article describes the case of a 70-year old man who complained of shadow vision in one eye and was diagnosed with occlusion of the superior temporal artery by a cholesterol embolus and resulting ischemic edema of the affected areas of the retina. The patient is said to have undergone rheological treatment and it identifies atherosclerotic plaque in the internal carotid artery as the source of his embolism. An image of the patient's fundoscopy is presented.

Introduction: The goal of this study was to examine the response of macular edema (ME) secondary to retinal vein occlusion (RVO) to predict macular edema course and re-injection intervals., Material and Methods: Twenty-four eyes from 24 patients with ME secondary to RVO, both central (CRVO) and branch (BRVO), were retrospectively included. All eyes received intravitreal bevacizumab therapy (1.25 mg/0.1 ml). Repetitive optical coherence tomography (OCT) examinations were performed to document the early macular edema response to treatment and the course of the disease during the first three monthly injections until the last follow-up 105 days after the first injection., Results: A significant ME reduction is present as early as three hours after the first injection of bevacizumab. This significant reduction of central retinal thickness (CRT) is present until the third post-injection day. The greatest reduction occurs during the first 24 hours. Patients who reach a CRT less than 300 µm after 24 hours (day 1) have no recurrence after 30 days. Patients with a CRT over 300 µm on day 1 have a 50% rate of recurrence after 30 days. The favorable results of the first group are still present during the last follow-up examination, 105 days after the first injection., Discussion and Conclusion: An OCT examination, 24 hours after the first bevacizumab injection, has a prognostic value and can identify the patients that can tolerate longer intervals between injections, this results in fewer bevacizumab injections during the course of the disease. This way an individualization of the treatment, opposed to a fixed therapy pattern, can be implemented. Also, patients with poor prognosis can be identified early and treatment can be altered or intensified accordingly., Competing Interests: Die Autoren geben an, dass kein Interessenkonflikt besteht., (Georg Thieme Verlag KG Stuttgart · New York.)