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4. Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses

Author

Ray, Rashmi, Nait Mohamed, Faez Amokrane, Maurer, Daniel P., Huang, Jiachen, Alpay, Berk A., Ronsard, Larance, Xie, Zhenfei, Han, Julianna, Fernandez-Quintero, Monica, Phan, Quynh Anh, Ursin, Rebecca L., Vu, Mya, Kirsch, Kathrin H., Prum, Thavaleak, Rosado, Victoria C., Bracamonte-Moreno, Thalia, Okonkwo, Vintus, Bals, Julia, McCarthy, Caitlin, Nair, Usha, Kanekiyo, Masaru, Ward, Andrew B., Schmidt, Aaron G., Batista, Facundo D., and Lingwood, Daniel

Published
2024
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5. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., and Levy, Ofer

Published
2023
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6. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., and Levy, Ofer

Published
2023
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8. Rapid generation of potent antibodies by autonomous hypermutation in yeast

Author

Wellner, Alon, McMahon, Conor, Gilman, Morgan SA, Clements, Jonathan R, Clark, Sarah, Nguyen, Kianna M, Ho, Ming H, Hu, Vincent J, Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Wingler, Laura M, Schmidt, Aaron G, Marks, Debora S, Abraham, Jonathan, Kruse, Andrew C, and Liu, Chang C

Subjects
Prevention, Biotechnology, Vaccine Related, Immunization, Generic health relevance, Antibodies, Antibody Formation, Antigens, COVID-19, Humans, Peptide Library, Protein Engineering, Recombinant Proteins, SARS-CoV-2, Saccharomyces cerevisiae, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inherently slow, not always accessible and poorly compatible with many antigens. Here, we describe 'autonomous hypermutation yeast surface display' (AHEAD), a synthetic recombinant antibody generation technology that imitates somatic hypermutation inside engineered yeast. By encoding antibody fragments on an error-prone orthogonal DNA replication system, surface-displayed antibody repertoires continuously mutate through simple cycles of yeast culturing and enrichment for antigen binding to produce high-affinity clones in as little as two weeks. We applied AHEAD to generate potent nanobodies against the SARS-CoV-2 S glycoprotein, a G-protein-coupled receptor and other targets, offering a template for streamlined antibody generation at large.

Published
2021

9. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Author

Clausen, Thomas Mandel, Sandoval, Daniel R, Spliid, Charlotte B, Pihl, Jessica, Perrett, Hailee R, Painter, Chelsea D, Narayanan, Anoop, Majowicz, Sydney A, Kwong, Elizabeth M, McVicar, Rachael N, Thacker, Bryan E, Glass, Charles A, Yang, Zhang, Torres, Jonathan L, Golden, Gregory J, Bartels, Phillip L, Porell, Ryan N, Garretson, Aaron F, Laubach, Logan, Feldman, Jared, Yin, Xin, Pu, Yuan, Hauser, Blake M, Caradonna, Timothy M, Kellman, Benjamin P, Martino, Cameron, Gordts, Philip LSM, Chanda, Sumit K, Schmidt, Aaron G, Godula, Kamil, Leibel, Sandra L, Jose, Joyce, Corbett, Kevin D, Ward, Andrew B, Carlin, Aaron F, and Esko, Jeffrey D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Coronaviruses, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses Therapeutics and Interventions, Infection, Amino Acid Sequence, Angiotensin-Converting Enzyme 2, Betacoronavirus, Binding Sites, COVID-19, Cell Line, Coronavirus Infections, Heparin, Heparitin Sulfate, Humans, Kidney, Lung, Molecular Dynamics Simulation, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Binding, Protein Domains, Recombinant Proteins, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Virus Internalization, coronavirus, heparan sulfate, heparan sulfate-binding proteins, heparin, lung epithelial cells, pseudotyped virus, spike proteins, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Both ACE2 and heparin can bind independently to spike protein in vitro, and a ternary complex can be generated using heparin as a scaffold. Electron micrographs of spike protein suggests that heparin enhances the open conformation of the RBD that binds ACE2. On cells, spike protein binding depends on both heparan sulfate and ACE2. Unfractionated heparin, non-anticoagulant heparin, heparin lyases, and lung heparan sulfate potently block spike protein binding and/or infection by pseudotyped virus and authentic SARS-CoV-2 virus. We suggest a model in which viral attachment and infection involves heparan sulfate-dependent enhancement of binding to ACE2. Manipulation of heparan sulfate or inhibition of viral adhesion by exogenous heparin presents new therapeutic opportunities.

Published
2020

12. An epitope-enriched immunogen expands responses to a conserved viral site

Author

Caradonna, Timothy M., Ronsard, Larance, Yousif, Ashraf S., Windsor, Ian W., Hecht, Rachel, Bracamonte-Moreno, Thalia, Roffler, Anne A., Maron, Max J., Maurer, Daniel P., Feldman, Jared, Marchiori, Elisa, Barnes, Ralston M., Rohrer, Daniel, Lonberg, Nils, Oguin, Thomas H., III, Sempowski, Gregory D., Kepler, Thomas B., Kuraoka, Masayuki, Lingwood, Daniel, and Schmidt, Aaron G.

Published
2022
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13. Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis.

Author

Roffler, Anne A., Maurer, Daniel P., Lunn, Tamika J., Sironen, Tarja, Forbes, Kristian M., and Schmidt, Aaron G.

Subjects
HENDRA virus, VIRAL antigens, VIRAL antibodies, IMMUNE response, EBOLA virus, HUMORAL immunity, CORONAVIRUS diseases
Abstract

Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV). Bats often tolerate these viruses without noticeable adverse immunological effects or succumbing to disease. Previous studies have largely focused on the role of the bat's innate immune response to control viral pathogenesis, but little is known about bat adaptive immunity. A key component of adaptive immunity is the humoral response, comprised of antibodies that can specifically recognize viral antigens with high affinity. The antibody genes within the 1,400 known bat species are highly diverse, and these genetic differences help shape fundamental aspects of the antibody repertoire, including starting diversity and viral antigen recognition. Whether antibodies in bats protect, mediate viral clearance, and prevent transmission within bat populations is poorly defined. Furthermore, it is unclear how neutralizing activity and Fc-mediated effector functions contribute to bat immunity. Although bats have canonical Fc genes (e.g., mu, gamma, alpha, and epsilon), the copy number and sequences of their Fc genes differ from those of humans and mice. The function of bat antibodies targeting viral antigens has been speculated based on sequencing data and polyclonal sera, but functional and biochemical data of monoclonal antibodies are lacking. In this review, we summarize current knowledge of bat humoral immunity, including variation between species, their potential protective role(s) against viral transmission and replication, and address how these antibodies may contribute to population dynamics within bats communities. A deeper understanding of bat adaptive immunity will provide insight into immune control of transmission and replication for emerging viruses with the potential for zoonotic spillover. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Author

Tostanoski, Lisa H., Wegmann, Frank, Martinot, Amanda J., Loos, Carolin, McMahan, Katherine, Mercado, Noe B., Yu, Jingyou, Chan, Chi N., Bondoc, Stephen, Starke, Carly E., Nekorchuk, Michael, Busman-Sahay, Kathleen, Piedra-Mora, Cesar, Wrijil, Linda M., Ducat, Sarah, Custers, Jerome, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Jacob-Dolan, Catherine, Lin, Zijin, Mahrokhian, Shant H., Nampanya, Felix, Nityanandam, Ramya, Pessaint, Laurent, Porto, Maciel, Ali, Vaneesha, Benetiene, Dalia, Tevi, Komlan, Andersen, Hanne, Lewis, Mark G., Schmidt, Aaron G., Lauffenburger, Douglas A., Alter, Galit, Estes, Jacob D., Schuitemaker, Hanneke, Zahn, Roland, and Barouch, Dan H.

Published
2020
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20. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Rosendahl Huber, Sietske K., Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2020
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22. Characterization of SARS-CoV-2 Convalescent Patients’ Serological Repertoire Reveals High Prevalence of Iso–RBD Antibodies

Author

Curtis, Nicholas C., primary, Shin, Seungmin, additional, Hederman, Andrew P., additional, Connor, Ruth I., additional, Wieland-Alter, Wendy F., additional, Ionov, Steven, additional, Boylston, Jennifer, additional, Rose, Josh, additional, Sakharkar, Mrunal, additional, Dorman, Dana B., additional, Dessaint, John A., additional, Gwilt, Lorraine L., additional, Crowley, Andrew R., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Ashare, Alix, additional, Walker, Laura M., additional, Wright, Peter F., additional, Ackerman, Margaret E., additional, and Lee, Jiwon, additional

Published
2023
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24. Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV-2

Author

Wuo, Michael G., primary, Dugan, Amanda E., additional, Halim, Melanie, additional, Hauser, Blake M., additional, Feldman, Jared, additional, Caradonna, Timothy M., additional, Zhang, Shuting, additional, Pepi, Lauren E., additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Alter, Galit, additional, Garcia-Beltran, Wilfredo F., additional, Azadi, Parastoo, additional, Hung, Deb, additional, Schmidt, Aaron G., additional, and Kiessling, Laura L., additional

Published
2023
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25. A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters

Author

Ying, Baoling, primary, Darling, Tamarand L, additional, Desai, Pritesh, additional, Liang, Chieh-Yu, additional, Dmitriev, Igor P, additional, Soudani, Nadia, additional, Bricker, Traci L, additional, Kashentseva, Elena A, additional, Harastani, Houda H., additional, Schmidt, Aaron G, additional, Curiel, David T, additional, Boon, Adrianus C M, additional, and Diamond, Michael S, additional

Published
2023
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26. Mucosal vaccine-induced cross-reactive CD8+T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

Author

Ying, Baoling, Darling, Tamarand L., Desai, Pritesh, Liang, Chieh-Yu, Dmitriev, Igor P., Soudani, Nadia, Bricker, Traci, Kashentseva, Elena A., Harastani, Houda, Raju, Saravanan, Liu, Meizi, Schmidt, Aaron G., Curiel, David T., Boon, Adrianus C. M., and Diamond, Michael S.

Abstract

A nasally delivered chimpanzee adenoviral-vectored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (ChAd-SARS-CoV-2-S) is currently used in India (iNCOVACC). Here, we update this vaccine by creating ChAd-SARS-CoV-2-BA.5-S, which encodes a prefusion-stabilized BA.5 spike protein. Whereas serum neutralizing antibody responses induced by monovalent or bivalent adenoviral vaccines were poor against the antigenically distant XBB.1.5 strain and insufficient to protect in passive transfer experiments, mucosal antibody and cross-reactive memory T cell responses were robust, and protection was evident against WA1/2020 D614G and Omicron variants BQ.1.1 and XBB.1.5 in mice and hamsters. However, depletion of memory CD8+T cells before XBB.1.5 challenge resulted in loss of protection against upper and lower respiratory tract infection. Thus, nasally delivered vaccines stimulate mucosal immunity against emerging SARS-CoV-2 strains, and cross-reactive memory CD8+T cells mediate protection against lung infection by antigenically distant strains in the setting of low serum levels of cross-reactive neutralizing antibodies.

Published
2024
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27. Functional interrogation and mining of natively paired human VH:VL antibody repertoires

Author

Wang, Bo, DeKosky, Brandon J, Timm, Morgan R, Lee, Jiwon, Normandin, Erica, Misasi, John, Kong, Rui, McDaniel, Jonathan R, Delidakis, George, Leigh, Kendra E, Niezold, Thomas, Choi, Chang W, Viox, Elise G, Fahad, Ahmed, Cagigi, Alberto, Ploquin, Aurélie, Leung, Kwanyee, Yang, Eun Sung, Kong, Wing-Pui, Voss, William N, Schmidt, Aaron G, Moody, M Anthony, Ambrozak, David R, Henry, Amy R, Laboune, Farida, Ledgerwood, Julie E, Graham, Barney S, Connors, Mark, Douek, Daniel C, Sullivan, Nancy J, Ellington, Andrew D, Mascola, John R, and Georgiou, George

Published
2018
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31. Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Huber, Sietske K. Rosendahl, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2021
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35. Cross-reactive SARS-CoV-2 epitope targeted across donors informs immunogen design

Author

Hauser, Blake M., primary, Feldman, Jared, additional, Sangesland, Maya, additional, Ronsard, Larance, additional, St. Denis, Kerri J., additional, Sheehan, Maegan L., additional, Cao, Yi, additional, Boucau, Julie, additional, Windsor, Ian W., additional, Cheng, Agnes H., additional, Vu, Mya L., additional, Cardoso, Marcella R., additional, Kannegieter, Ty, additional, Balazs, Alejandro B., additional, Lingwood, Daniel, additional, Garcia-Beltran, Wilfredo F., additional, and Schmidt, Aaron G., additional

Published
2022
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36. SARS-CoV-2 Serosurveys: How Antigen, Isotype and Threshold Choices Affect the Outcome

Author

Binder, Raquel A, primary, Fujimori, Gavin F, additional, Forconi, Catherine S, additional, Reed, George W, additional, Silva, Leandro S, additional, Lakshmi, Priya Saikumar, additional, Higgins, Amanda, additional, Cincotta, Lindsey, additional, Dutta, Protiva, additional, Salive, Marie-Claire, additional, Mangolds, Virginia, additional, Anya, Otuwe, additional, Calvo Calle, J Mauricio, additional, Nixon, Thomas, additional, Tang, Qiushi, additional, Wessolossky, Mireya, additional, Wang, Yang, additional, Ritacco, Dominic A, additional, Bly, Courtney S, additional, Fischinger, Stephanie, additional, Atyeo, Caroline, additional, Oluoch, Peter O, additional, Odwar, Boaz, additional, Bailey, Jeffrey A, additional, Maldonado-Contreras, Ana, additional, Haran, John P, additional, Schmidt, Aaron G, additional, Cavacini, Lisa, additional, Alter, Galit, additional, and Moormann, Ann M, additional

Published
2022
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37. Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

Author

Tas, Jeroen M.J., primary, Koo, Ja-Hyun, additional, Lin, Ying-Cing, additional, Xie, Zhenfei, additional, Steichen, Jon M., additional, Jackson, Abigail M., additional, Hauser, Blake M., additional, Wang, Xuesong, additional, Cottrell, Christopher A., additional, Torres, Jonathan L., additional, Warner, John E., additional, Kirsch, Kathrin H., additional, Weldon, Stephanie R., additional, Groschel, Bettina, additional, Nogal, Bartek, additional, Ozorowski, Gabriel, additional, Bangaru, Sandhya, additional, Phelps, Nicole, additional, Adachi, Yumiko, additional, Eskandarzadeh, Saman, additional, Kubitz, Michael, additional, Burton, Dennis R., additional, Lingwood, Daniel, additional, Schmidt, Aaron G., additional, Nair, Usha, additional, Ward, Andrew B., additional, Schief, William R., additional, and Batista, Facundo D., additional

Published
2022
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38. Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain

Author

Raymond, Donald D, Stewart, Shaun M, Lee, Jiwon, Ferdman, Jack, Bajic, Goran, Do, Khoi T, Ernandes, Michael J, Suphaphiphat, Pirada, Settembre, Ethan C, Dormitzer, Philip R, Del Giudice, Giuseppe, Finco, Oretta, Kang, Tae Hyun, Ippolito, Gregory C, Georgiou, George, Kepler, Thomas B, Haynes, Barton F, Moody, M Anthony, Liao, Hua-Xin, Schmidt, Aaron G, and Harrison, Stephen C

Subjects
Influenza vaccines -- Health aspects -- Research, B cells -- Health aspects -- Research, Antibodies -- Research, Biological sciences, Health
Abstract

Author(s): Donald D Raymond [1]; Shaun M Stewart [2]; Jiwon Lee [3]; Jack Ferdman [2]; Goran Bajic [1]; Khoi T Do [1]; Michael J Ernandes [1, 4]; Pirada Suphaphiphat [2]; [...]

Published
2016
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40. SARS-CoV-2 Serosurveys: How antigen, isotype and threshold choices affect the outcome

Author

Binder, Raquel A., primary, Fujimori, Gavin F., additional, Forconi, Catherine S., additional, Reed, George W., additional, Silva, Leandro S., additional, Lakshmi, Priya Saikumar, additional, Higgins, Amanda, additional, Cincotta, Lindsey, additional, Dutta, Protiva, additional, Salive, Marie-Claire, additional, Mangolds, Virginia, additional, Anya, Otuwe, additional, Calle, J. Mauricio Calvo, additional, Nixon, Thomas, additional, Tang, Qiushi, additional, Wessolossky, Mireya, additional, Wang, Yang, additional, Ritacco, Dominic A., additional, Bly, Courtney S., additional, Fischinger, Stephanie, additional, Atyeo, Caroline, additional, Oluoch, Peter O., additional, Odwar, Boaz, additional, Bailey, Jeffrey A., additional, Maldonado-Contreras, Ana, additional, Haran, John P., additional, Schmidt, Aaron G., additional, Cavacini, Lisa, additional, Alter, Galit, additional, and Moormann, Ann M., additional

Published
2022
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42. Durability of Heterologous and Homologous COVID-19 Vaccine Boosts

Author

Tan, C. Sabrina, primary, Collier, Ai-ris Y., additional, Yu, Jingyou, additional, Liu, Jinyan, additional, Chandrashekar, Abishek, additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, He, Xuan, additional, Roy, Vicky, additional, Hauser, Blake M., additional, Munt, Jennifer E., additional, Mallory, Michael L., additional, Mattocks, Melissa, additional, Powers, John M., additional, Meganck, Rita M., additional, Rowe, Marjorie, additional, Hemond, Rachel, additional, Bondzie, Esther A., additional, Jaegle, Kate H., additional, Baric, Ralph S., additional, Schmidt, Aaron G., additional, Alter, Galit, additional, Le Gars, Mathieu, additional, Sadoff, Jerald, additional, and Barouch, Dan H., additional

Published
2022
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47. Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

Author

Hauser, Blake M., primary, Sangesland, Maya, additional, St. Denis, Kerri J., additional, Lam, Evan C., additional, Case, James Brett, additional, Windsor, Ian W., additional, Feldman, Jared, additional, Caradonna, Timothy M., additional, Kannegieter, Ty, additional, Diamond, Michael S., additional, Balazs, Alejandro B., additional, Lingwood, Daniel, additional, and Schmidt, Aaron G., additional

Published
2022
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48. mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

Author

Garcia-Beltran, Wilfredo F., primary, St. Denis, Kerri J., additional, Hoelzemer, Angelique, additional, Lam, Evan C., additional, Nitido, Adam D., additional, Sheehan, Maegan L., additional, Berrios, Cristhian, additional, Ofoman, Onosereme, additional, Chang, Christina C., additional, Hauser, Blake M., additional, Feldman, Jared, additional, Roederer, Alex L., additional, Gregory, David J., additional, Poznansky, Mark C., additional, Schmidt, Aaron G., additional, Iafrate, A. John, additional, Naranbhai, Vivek, additional, and Balazs, Alejandro B., additional

Published
2022
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49. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

Author

Nanishi, Etsuro, primary, Borriello, Francesco, additional, O’Meara, Timothy R., additional, McGrath, Marisa E., additional, Saito, Yoshine, additional, Haupt, Robert E., additional, Seo, Hyuk-Soo, additional, van Haren, Simon D., additional, Cavazzoni, Cecilia B., additional, Brook, Byron, additional, Barman, Soumik, additional, Chen, Jing, additional, Diray-Arce, Joann, additional, Doss-Gollin, Simon, additional, De Leon, Maria, additional, Prevost-Reilly, Alejandra, additional, Chew, Katherine, additional, Menon, Manisha, additional, Song, Kijun, additional, Xu, Andrew Z., additional, Caradonna, Timothy M., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Sherman, Amy C., additional, Baden, Lindsey R., additional, Ernst, Robert K., additional, Dillen, Carly, additional, Weston, Stuart M., additional, Johnson, Robert M., additional, Hammond, Holly L., additional, Mayer, Romana, additional, Burke, Allen, additional, Bottazzi, Maria E., additional, Hotez, Peter J., additional, Strych, Ulrich, additional, Chang, Aiquan, additional, Yu, Jingyou, additional, Sage, Peter T., additional, Barouch, Dan H., additional, Dhe-Paganon, Sirano, additional, Zanoni, Ivan, additional, Ozonoff, Al, additional, Frieman, Matthew B., additional, Levy, Ofer, additional, and Dowling, David J., additional

Published
2022
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50. Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

Author

Amraei, Razie, primary, Xia, Chaoshuang, additional, Olejnik, Judith, additional, White, Mitchell R., additional, Napoleon, Marc A., additional, Lotfollahzadeh, Saran, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Chitalia, Vipul, additional, Mühlberger, Elke, additional, Costello, Catherine E., additional, and Rahimi, Nader, additional

Published
2022
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