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2. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Author

Lapatto, H. A. (Helena A. K.), Kuusela, M. (Minna), Heikkinen, A. (Aino), Muniandy, M. (Maheswary), van der Kolk, B. W. (Birgitta W.), Gopalakrishnan, S. (Swetha), Pöllänen, N. (Noora), Sandvik, M. (Martin), Schmidt, M. S. (Mark S.), Heinonen, S. (Sini), Saari, S. (Sina), Kuula, J. (Juho), Hakkarainen, A. (Antti), Tampio, J. (Janne), Saarinen, T. (Tuure), Taskinen, M.-R. (Marja-Riitta), Lundbom, N. (Nina), Groop, P.-H. (Per-Henrik), Tiirola, M. (Marja), Katajisto, P. (Pekka), Lehtonen, M. (Marko), Brenner, C. (Charles), Kaprio, J. (Jaakko), Pekkala, S. (Satu), Ollikainen, M. (Miina), Pietiläinen, K. H. (Kirsi H.), Pirinen, E. (Eija), Lapatto, H. A. (Helena A. K.), Kuusela, M. (Minna), Heikkinen, A. (Aino), Muniandy, M. (Maheswary), van der Kolk, B. W. (Birgitta W.), Gopalakrishnan, S. (Swetha), Pöllänen, N. (Noora), Sandvik, M. (Martin), Schmidt, M. S. (Mark S.), Heinonen, S. (Sini), Saari, S. (Sina), Kuula, J. (Juho), Hakkarainen, A. (Antti), Tampio, J. (Janne), Saarinen, T. (Tuure), Taskinen, M.-R. (Marja-Riitta), Lundbom, N. (Nina), Groop, P.-H. (Per-Henrik), Tiirola, M. (Marja), Katajisto, P. (Pekka), Lehtonen, M. (Marko), Brenner, C. (Charles), Kaprio, J. (Jaakko), Pekkala, S. (Satu), Ollikainen, M. (Miina), Pietiläinen, K. H. (Kirsi H.), and Pirinen, E. (Eija)

Abstract

Nicotinamide adenine dinucleotide (NAD⁺) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans. Twenty body mass index (BMI)–discordant monozygotic twin pairs were supplemented with an escalating dose of NR (250 to 1000 mg/day) for 5 months. NR improved systemic NAD⁺ metabolism, muscle mitochondrial number, myoblast differentiation, and gut microbiota composition in both cotwins. NR also showed a capacity to modulate epigenetic control of gene expression in muscle and adipose tissue in both cotwins. However, NR did not ameliorate adiposity or metabolic health. Overall, our results suggest that NR acts as a potent modifier of NAD⁺ metabolism, muscle mitochondrial biogenesis and stem cell function, gut microbiota, and DNA methylation in humans irrespective of BMI.

Published
2023

4. Review: CO2 capturing methods of the last two decades.

Author

Kammerer, S., Borho, I., Jung, J., and Schmidt, M. S.

Abstract

Due to the annual increase in CO2 emissions, climate change continues to progress. In order to achieve the goals set in the Paris Climate Agreement, CO2 capturing measures are necessary in addition to the reduction in carbon dioxide emissions. This review article describes and discusses the CO2 capturing methods published in the last 20 years. Processes for absorption, gas–solid reaction, adsorption, cryogenic processes, membrane processes and the capture of carbon dioxide with natural inclusion were examined in more detail. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Poster Session 2: CRT: techniques and imaging

Author

Beynon, R. P., primary, Argyle, R. A., additional, Aghamohammadzadeh, R., additional, Pearce, K. A., additional, Ray, S. G., additional, Davidson, N. C., additional, Beynon, R. P., additional, Scott, P. A., additional, Turner, N. G., additional, Yue, A. M., additional, Roberts, P. R., additional, Morgan, J. M., additional, Duparc, A., additional, Delarche, N., additional, Froehlig, G., additional, Brachmann, J., additional, Mondoly, P., additional, Ziglio, F., additional, Cazeau, S., additional, Thomas, D., additional, Fraser, A. G., additional, Penny, A., additional, Yousef, Z. R., additional, Ciarka, A., additional, Bertini, M., additional, Delgado, V., additional, Van Bommel, R. J., additional, Borleffs, C. J. W., additional, Van De Veire, N., additional, Schalij, M. J., additional, Bax, J., additional, Ajmone Marsan, N., additional, Nucifora, G., additional, Bax, J. J., additional, Dabrowski, P., additional, Kleinrok, A., additional, Bordachar, P., additional, De Guillebon, M., additional, Thambo, J. B., additional, Ploux, S., additional, Deplagne, A., additional, Ritter, P., additional, Haissaguerre, M., additional, Clementy, J., additional, Parisi, Q., additional, Messano, L., additional, Santamaria, M., additional, Angeloni, G., additional, Alessandrini, F., additional, Mlynarski, R., additional, Wlodyka, A., additional, Kargul, W., additional, Sosnowski, M., additional, Tomasi, C., additional, Mosconi, R., additional, Corsi, C., additional, Severi, S., additional, Veronesi, F., additional, Ricci, V., additional, Pepoli, R., additional, Margheri, M., additional, Greenberg, S., additional, Gupta, M., additional, Burke, J., additional, Seifert, M., additional, Schau, T., additional, Koglek, W., additional, Neuss, M., additional, Meyhoefer, J., additional, Butter, C., additional, Curcio, A., additional, Cascini, G. L., additional, Cipullo, S., additional, Restuccia, A., additional, Santarpia, G., additional, Cuko, A., additional, Leone, A., additional, Indolfi, C., additional, Gutleben, K., additional, Noelker, G. N., additional, Marschang, H. M., additional, Schmidt, M. S., additional, Ritscher, G. R., additional, Rohkohl, C. R., additional, Brachmann, J. B., additional, Sinha, A. M. S., additional, Min, X., additional, Hellman, H., additional, Lall, C., additional, Rosenberg, S., additional, Ginks, M., additional, Chinchapatnam, P., additional, Hamid, S., additional, Sinclair, S., additional, Totman, J., additional, Carr-White, G., additional, Razavi, R., additional, Rinaldi, C. A., additional, Sztaniszlav, A., additional, Przibille, O., additional, Nowak, B., additional, Schulte-Hahn, B., additional, Bogaard, M. D., additional, Doevendans, P. A., additional, Van Wessel, H., additional, Hauer, R. N., additional, Meine, M., additional, Ryu, K., additional, D'avila, A., additional, Heist, E. K., additional, Chou, J., additional, Yang, M., additional, and Singh, J. P., additional

Published
2009
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25. Surface Enhanced Raman Spectroscopy for Quantitative Analysis: Results of a Large-Scale European Multi-Instrument Interlaboratory Study

Author

Fatima Alsamad, Pellegrino Musto, Jakub Dybas, Valérie Untereiner, Michael Stenbæk Schmidt, Fabrizio Giorgis, Elena Rusu, Howbeer Muhamadali, Maria Paula M. Marques, Alessandro Chiadò, Karen Faulds, Stefano Fornasaro, Guillaume Falgayrac, Hrvoje Gebavi, Duncan Graham, Malama Chisanga, Valter Sergo, Tomas Rindzevicius, Cédric Malherbe, Chiara Novara, Amuthachelvi Daniel, Ewelina Wiercigroch, Fiona M. Lyng, Alois Bonifacio, Lucio Litti, Stacey Laing, Monica Baia, Renzo Vanna, Olivier Piot, Carlo Morasso, Claudia Beleites, Elisa Mitri, Hugh J. Byrne, Moreno Meneghetti, Vlasta Mohaček-Grošev, Pietro La Manna, Gauthier Eppe, Ganesh D. Sockalingum, Kamilla Malek, Mihaela Chis, Luís A. E. Batista de Carvalho, Royston Goodacre, Guillaume Penel, Marianna Pannico, Fornasaro, S., Alsamad, F., Baia, M., Batista De Carvalho, L. A. E., Beleites, C., Byrne, H. J., Chiado, A., Chis, M., Chisanga, M., Daniel, A., Dybas, J., Eppe, G., Falgayrac, G., Faulds, K., Gebavi, H., Giorgis, F., Goodacre, R., Graham, D., La Manna, P., Laing, S., Litti, L., Lyng, F. M., Malek, K., Malherbe, C., Marques, M. P. M., Meneghetti, M., Mitri, E., Mohacek-Grosev, V., Morasso, C., Muhamadali, H., Musto, P., Novara, C., Pannico, M., Penel, G., Piot, O., Rindzevicius, T., Rusu, E. A., Schmidt, M. S., Sergo, V., Sockalingum, G. D., Untereiner, V., Vanna, R., Wiercigroch, E., and Bonifacio, A.

Subjects
Analyte, Standardization, Surface enhanced Raman, 010402 general chemistry, Physical Chemistry, 01 natural sciences, Article, SERS spectroscopy quantitative analysis Raman, Analytical Chemistry, Surface chemical, QD, Cost action, interlaboratory study, Analytic Chemistry, SERS, Chemistry, Scale (chemistry), 010401 analytical chemistry, Analytical technique, Surface-enhanced Raman spectroscopy, 0104 chemical sciences, Interdisciplinary Natural Sciences, Quantitative analysis (finance), Biochemical engineering, SERS, Raman, substrates, colloids, interlaboratory study
Abstract

Surface-enhanced Raman scattering (SERS) is a powerful and sensitive technique for the detection of fingerprint sig-nals of molecules and for the investigation of a series of surface chemical reactions. Many studies introduced quantita-tive applications of SERS in various fields and several SERS methods have been implemented for each specific applica- tion, ranging in performance characteristics, analytes used, instruments, and analytical matrices. In general, very few methods have been validated according to international guidelines. As a consequence, the application of SERS in high-ly- regulated environments is still considered risky and the perception of a poorly reproducible and insufficiently robust analytical technique has persistently retarded its routine implementation. Collaborative trials are a type of interlabora-tory study (ILS) frequently performed to ascertain the quality of a single analytical method. The idea of an ILS of quan- tification with SERS arose within the framework of Working Group 1 (WG1) of the COST Action BM1401 Ra-man4Clinics32 in an effort to overcome the problematic perception of quantitative SERS methods. Here we report the first interlaboratory SERS study ever conducted, involving 15 laboratories and 41 researchers. In this study we tried to define a methodology to assess the reproducibility and trueness of a quantitative SERS method, and to compare differ- ent methods. In our opinion, this is a first important step toward a “standardization” process of SERS protocols, not proposed by a single laboratory but by a larger community.

Published
2020
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28. To whom is NCSBN accountable?

Author

Schmidt MS

Subjects
American Nurses' Association, Governing Board, Humans, United States, Licensure, Nursing, Social Responsibility
Published
1980

35. Credit for what you know.

Author

Schmidt MS and Lyons W

Subjects
Curriculum, Education, Nursing standards, New York, Education, Nursing, Baccalaureate, Education, Nursing, Diploma Programs, Educational Measurement
Published
1969

40. Legal considerations in nursing.

Author

Schmidt MS

Subjects
Education, Nursing, Legislation, Nursing, Licensure, Nursing, New York, Nursing, Societies, Nursing
Published
1968

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