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571 results on '"Schmitt-Graeff, Annette"'

1. ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Author

Maas-Bauer, Kristina, Stell, Anna-Verena, Yan, Kai-Li, de Vega, Enrique, Vinnakota, Janaki Manoja, Unger, Susanne, Núñez, Nicolas, Norona, Johana, Talvard-Balland, Nana, Koßmann, Stefanie, Schwan, Carsten, Miething, Cornelius, Martens, Uta S., Shoumariyeh, Khalid, Nestor, Rosa P., Duquesne, Sandra, Hanke, Kathrin, Rackiewicz, Michal, Hu, Zehan, El Khawanky, Nadia, Taromi, Sanaz, Andrlova, Hana, Faraidun, Hemin, Walter, Stefanie, Pfeifer, Dietmar, Follo, Marie, Waldschmidt, Johannes, Melchinger, Wolfgang, Rassner, Michael, Wehr, Claudia, Schmitt-Graeff, Annette, Halbach, Sebastian, Liao, James, Häcker, Georg, Brummer, Tilman, Dengjel, Joern, Andrieux, Geoffroy, Grosse, Robert, Tugues, Sonia, Blazar, Bruce R., Becher, Burkhard, Boerries, Melanie, and Zeiser, Robert

Published
2024
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2. C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib

Author

Kapp, Friedrich G., Kretschmer, Stefanie, Beckmann, Cora C.A., Wäsch, Lena, Molitor, Anne, Carapito, Raphaël, Schubert, Mario, Lucas, Nadja, Conrad, Solène, Poignant, Sylvaine, Isidor, Bertrand, Rohlfs, Meino, Kisaarslan, Ayşenur Paç, Schanze, Denny, Zenker, Martin, Schmitt-Graeff, Annette, Strahm, Brigitte, Peters, Anke, Yoshimi, Ayami, Driever, Wolfgang, Zillinger, Thomas, Günther, Claudia, Maharana, Shovamayee, Guan, Kaomei, Klein, Christoph, Ehl, Stephan, Niemeyer, Charlotte M., Unal, Ekrem, Bahram, Seiamak, Hauck, Fabian, Lee-Kirsch, Min Ae, and Speckmann, Carsten

Published
2023
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5. Normal Bone Marrow

Author

Beham-Schmid, Christine, Schmitt-Graeff, Annette, Moinfar, Farid, Series Editor, Beham-Schmid, Christine, and Schmitt-Graeff, Annette

Published
2020
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6. Malignant Lymphomas

Author

Beham-Schmid, Christine, Schmitt-Graeff, Annette, Moinfar, Farid, Series Editor, Beham-Schmid, Christine, and Schmitt-Graeff, Annette

Published
2020
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7. Mastocytosis

Author

Beham-Schmid, Christine, Schmitt-Graeff, Annette, Moinfar, Farid, Series Editor, Beham-Schmid, Christine, and Schmitt-Graeff, Annette

Published
2020
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15. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

Author

Arber, Daniel A., Orazi, Attilio, Hasserjian, Robert P., Borowitz, Michael J., Calvo, Katherine R., Kvasnicka, Hans-Michael, Wang, Sa A., Bagg, Adam, Barbui, Tiziano, Branford, Susan, Bueso-Ramos, Carlos E., Cortes, Jorge E., Dal Cin, Paola, DiNardo, Courtney D., Dombret, Hervé, Duncavage, Eric J., Ebert, Benjamin L., Estey, Elihu H., Facchetti, Fabio, Foucar, Kathryn, Gangat, Naseema, Gianelli, Umberto, Godley, Lucy A., Gökbuget, Nicola, Gotlib, Jason, Hellström-Lindberg, Eva, Hobbs, Gabriela S., Hoffman, Ronald, Jabbour, Elias J., Kiladjian, Jean-Jacques, Larson, Richard A., Le Beau, Michelle M., Loh, Mignon L.-C., Löwenberg, Bob, Macintyre, Elizabeth, Malcovati, Luca, Mullighan, Charles G., Niemeyer, Charlotte, Odenike, Olatoyosi M., Ogawa, Seishi, Orfao, Alberto, Papaemmanuil, Elli, Passamonti, Francesco, Porkka, Kimmo, Pui, Ching-Hon, Radich, Jerald P., Reiter, Andreas, Rozman, Maria, Rudelius, Martina, Savona, Michael R., Schiffer, Charles A., Schmitt-Graeff, Annette, Shimamura, Akiko, Sierra, Jorge, Stock, Wendy A., Stone, Richard M., Tallman, Martin S., Thiele, Jürgen, Tien, Hwei-Fang, Tzankov, Alexandar, Vannucchi, Alessandro M., Vyas, Paresh, Wei, Andrew H., Weinberg, Olga K., Wierzbowska, Agnieszka, Cazzola, Mario, Döhner, Hartmut, and Tefferi, Ayalew

Published
2022
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17. Immunization against poly- N -acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity

Author

Hülsdünker, Jan, Thomas, Oliver S., Haring, Eileen, Unger, Susanne, Núñez, Nicolás Gonzalo, Tugues, Sonia, Gao, Zhan, Duquesne, Sandra, Cywes-Bentley, Colette, Oyardi, Ozlem, Kirschnek, Susanne, Schmitt-Graeff, Annette, Pabst, Oliver, Koenecke, Christian, Duyster, Justus, Apostolova, Petya, Blaser, Martin J., Becher, Burkhard, Pier, Gerald B., Häcker, Georg, and Zeiser, Robert

Published
2019

18. Proposed global prognostic score for systemic mastocytosis: a retrospective prognostic modelling study

Author

Muñoz-González, Javier I, Álvarez-Twose, Iván, Jara-Acevedo, María, Zanotti, Roberta, Perkins, Cecelia, Jawhar, Mohamad, Sperr, Wolfgang R, Shoumariyeh, Khalid, Schwaab, Juliana, Greiner, Georg, Henriques, Ana, Caldas, Carolina, Fernández-Giménez, Carlos, Sánchez-Muñoz, Laura, Mayado, Andrea, Pérez-Pons, Alba, Schmitt-Graeff, Annette, Duyster, Justus, Tanasi, Ilaria, Olivieri, Francesco, Mora-Casterá, Elvira, Luna, Irene, Senent, Leonor, Bañas, Maria-Helena, Nuñez-García, Amanda, Jurado-Chacón, Manuel, Martín-Sánchez, Guillermo, Colado, Enrique, Xicoy, Blanca, Gener-Ricós, Georgina, Gotlib, Jason, Bonadonna, Patrizia, Reiter, Andreas, Valent, Peter, García-Montero, Andrés C, and Orfao, Alberto

Published
2021
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19. Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure

Author

Kreutmair, Stefanie, Erlacher, Miriam, Andrieux, Geoffroy, Istvanffy, Rouzanna, Mueller-Rudorf, Alina, Zwick, Melissa, Ruckert, Tamina, Pantic, Milena, Poggio, Teresa, Shoumariyeh, Khalid, Mueller, Tony A., Kawaguchi, Hiroyuki, Follo, Marie, Klingeberg, Cathrin, Wlodarski, Marcin, Baumann, Irith, Pfeifer, Dietmar, Kulinski, Michal, Rudelius, Martina, Lemeer, Simone, Kuster, Bernhard, Dierks, Christine, Peschel, Christian, Cabezas-Wallscheid, Nina, Duque-Afonso, Jesus, Zeiser, Robert, Cleary, Michael L., Schindler, Detlev, Schmitt-Graeff, Annette, Boerries, Melanie, Niemeyer, Charlotte M., Oostendorp, Robert A.J., Duyster, Justus, and Illert, Anna Lena

Subjects
DNA damage -- Genetic aspects, Fanconi's anemia -- Genetic aspects, Genes -- Genetic aspects, Disease susceptibility -- Genetic aspects, Hematopoietic stem cells, Proteins -- Genetic aspects, Health care industry
Abstract

Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function, and cancer susceptibility. Diagnosis of IBMFS presents a major challenge due to the large variety of associated phenotypes, and novel, clinically relevant biomarkers are urgently needed. Our study identified nuclear interaction partner of ALK (NIPA) as an IBMFS gene, as it is significantly downregulated in a distinct subset of myelodysplastic syndrome-type (MDS-type) refractory cytopenia in children. Mechanistically, we showed that NIPA is major player in the Fanconi anemia (FA) pathway, which binds FANCD2 and regulates its nuclear abundance, making it essential for a functional DNA repair/FA/BRCA pathway. In a knockout mouse model, Nipa deficiency led to major cell-intrinsic defects, including a premature aging phenotype, with accumulation of DNA damage in hematopoietic stem cells (HSCs). Induction of replication stress triggered a reduction in and functional decline of murine HSCs, resulting in complete bone marrow failure and death of the knockout mice with 100% penetrance. Taken together, the results of our study add NIPA to the short list of FA-associated proteins, thereby highlighting its potential as a diagnostic marker and/or possible target in diseases characterized by hematopoietic failure., Introduction Inherited BM failure syndromes (IBMFSs) include a wide spectrum of hematological disorders characterized by hypocellular BM and peripheral blood (PB) cytopenia (1, 2). The best-characterized IBMFSs are Fanconi anemia [...]

Published
2020
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22. Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease.

Author

Czech, Marie, Schneider, Sophia, Peltokangas, Nina, El Khawanky, Nadia, Ghimire, Sakhila, Andrieux, Geoffroy, Hülsdünker, Jan, Krausz, Máté, Proietti, Michele, Braun, Lukas M., Rückert, Tamina, Langenbach, Marlene, Schmidt, Dominik, Martin, Ina, Wenger, Valentin, de Vega, Enrique, Haring, Eileen, Pourjam, Mohsen, Pfeifer, Dietmar, and Schmitt-Graeff, Annette

Subjects
ACUTE diseases, GRAFT versus host disease, INSULIN-like growth factor receptors, SOMATOMEDIN C, LIPOCALIN-2, NEUTROPHILS
Abstract

Acute graft-versus-host disease (aGVHD) is a life-threatening complication of allogeneic hematopoietic cell transplantation (allo-HCT), for which therapeutic options are limited. Strategies to promote intestinal tissue tolerance during aGVHD may improve patient outcomes. Using single-cell RNA sequencing, we identified a lipocalin-2 (LCN2)–expressing neutrophil population in mice with intestinal aGVHD. Transfer of LCN2-overexpressing neutrophils or treatment with recombinant LCN2 reduced aGVHD severity, whereas the lack of epithelial or hematopoietic LCN2 enhanced aGVHD severity and caused microbiome alterations. Mechanistically, LCN2 induced insulin-like growth factor 1 receptor (IGF-1R) signaling in macrophages through the LCN2 receptor SLC22A17, which increased interleukin-10 (IL-10) production and reduced major histocompatibility complex class II (MHCII) expression. Transfer of LCN2-pretreated macrophages reduced aGVHD severity but did not reduce graft-versus-leukemia effects. Furthermore, LCN2 expression correlated with IL-10 expression in intestinal biopsies in multiple cohorts of patients with aGVHD, and LCN2 induced IGF-1R signaling in human macrophages. Collectively, we identified a LCN2-expressing intestinal neutrophil population that reduced aGVHD severity by decreasing MHCII expression and increasing IL-10 production in macrophages. This work provides the foundation for administration of LCN2 as a therapeutic approach for aGVHD. Editor's summary: An approach to treating aGVHD. Acute graft-versus-host disease (aGVHD) is a major complication after allogeneic hematopoietic cell transplant (allo-HCT) for which there are limited treatment options. As aGVHD often presents with gastrointestinal (GI) tract inflammation, studying drivers of disease in the GI tract may identify new therapeutic avenues. Here, Czech et al. identified a population of lipocalin-2 (LCN2)–expressing neutrophils that were increased in the GI tract of mice with aGVHD and exhibited a tolerogenic effect by promoting IL-10 production and decreasing MHCII expression on macrophages; similar observations were made across multiple cohorts of patients who received allo-HCT. Transfer of LCN2-overexpressing neutrophils or administration of recombinant LCN2 reduced aGVHD severity across multiple murine allo-HCT models, supporting further development of LCN2 as a therapeutic for aGVHD. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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27. Supplementary Figures 1-7 from Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice

Author

Osswald, Lena, primary, Hamarsheh, Shaima'a, primary, Uhl, Franziska Maria, primary, Andrieux, Geoffroy, primary, Klein, Claudius, primary, Dierks, Christine, primary, Duquesne, Sandra, primary, Braun, Lukas M., primary, Schmitt-Graeff, Annette, primary, Duyster, Justus, primary, Boerries, Melanie, primary, Brummer, Tilman, primary, and Zeiser, Robert, primary

Published
2023
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28. Data from Oncogenic KrasG12D Activation in the Nonhematopoietic Bone Marrow Microenvironment Causes Myelodysplastic Syndrome in Mice

Author

Osswald, Lena, primary, Hamarsheh, Shaima'a, primary, Uhl, Franziska Maria, primary, Andrieux, Geoffroy, primary, Klein, Claudius, primary, Dierks, Christine, primary, Duquesne, Sandra, primary, Braun, Lukas M., primary, Schmitt-Graeff, Annette, primary, Duyster, Justus, primary, Boerries, Melanie, primary, Brummer, Tilman, primary, and Zeiser, Robert, primary

Published
2023
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29. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

Author

Hamarsheh, Shaima’a, Osswald, Lena, Saller, Benedikt S., Unger, Susanne, De Feo, Donatella, Vinnakota, Janaki Manoja, Konantz, Martina, Uhl, Franziska M., Becker, Heiko, Lübbert, Michael, Shoumariyeh, Khalid, Schürch, Christoph, Andrieux, Geoffroy, Venhoff, Nils, Schmitt-Graeff, Annette, Duquesne, Sandra, Pfeifer, Dietmar, Cooper, Matthew A., Lengerke, Claudia, Boerries, Melanie, Duyster, Justus, Niemeyer, Charlotte M., Erlacher, Miriam, Blazar, Bruce R., Becher, Burkard, Groß, Olaf, Brummer, Tilman, and Zeiser, Robert

Published
2020
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30. Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Author

Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A., Kuball, Jürgen, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J., Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Published
2016
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31. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, and Zeiser, Robert

Subjects
Interleukin-15 -- Health aspects, Gene mutation -- Health aspects, Sorafenib -- Patient outcomes, Gene expression -- Health aspects, Acute myelocytic leukemia -- Genetic aspects -- Development and progression -- Drug therapy, Biological sciences, Health
Abstract

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD[sup.+] leukemia cells. This synergized with the allogeneic CD8[sup.+] T cell response, leading to long-term survival in six mouse models of FLT3-ITD[sup.+] AML. Sorafenib-related IL-15 production caused an increase in CD8[sup.+]CD107a[sup.+]IFN-[gamma][sup.+] T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription. Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro. Human FLT3-ITD[sup.+] AML cells obtained from sorafenib responders following sorafenib therapy showed increased levels of IL-15, phosphorylated IRF7, and a transcriptionally active IRF7 chromatin state. The mitochondrial spare respiratory capacity and glycolytic capacity of CD8[sup.+] T cells increased upon sorafenib treatment in sorafenib responders but not in nonresponders. Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans. Therefore, sorafenib treatment has the potential to contribute to an immune-mediated cure of FLT3-ITD-mutant AML relapse, an otherwise fatal complication after allo-HCT., Author(s): Nimitha R Mathew [1, 2]; Francis Baumgartner [1]; Lukas Braun [1]; David O'Sullivan [3]; Simone Thomas [4]; Miguel Waterhouse [1]; Tony A Müller [1]; Kathrin Hanke [1, 2]; Sanaz [...]

Published
2018
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32. Supplementary Data from miR-146a Controls Immune Response in the Melanoma Microenvironment

Author

Mastroianni, Justin, primary, Stickel, Natalie, primary, Andrlova, Hana, primary, Hanke, Kathrin, primary, Melchinger, Wolfgang, primary, Duquesne, Sandra, primary, Schmidt, Dominik, primary, Falk, Martina, primary, Andrieux, Geoffroy, primary, Pfeifer, Dietmar, primary, Dierbach, Heide, primary, Schmitt-Graeff, Annette, primary, Meiss, Frank, primary, Boerries, Melanie, primary, and Zeiser, Robert, primary

Published
2023
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33. Data from miR-146a Controls Immune Response in the Melanoma Microenvironment

Author

Mastroianni, Justin, primary, Stickel, Natalie, primary, Andrlova, Hana, primary, Hanke, Kathrin, primary, Melchinger, Wolfgang, primary, Duquesne, Sandra, primary, Schmidt, Dominik, primary, Falk, Martina, primary, Andrieux, Geoffroy, primary, Pfeifer, Dietmar, primary, Dierbach, Heide, primary, Schmitt-Graeff, Annette, primary, Meiss, Frank, primary, Boerries, Melanie, primary, and Zeiser, Robert, primary

Published
2023
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34. Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Author

Schönle, Anne, Hartl, Frederike A., Mentzel, Jan, Nöltner, Theresa, Rauch, Katharina S., Prestipino, Alessandro, Wohlfeil, Sebastian A., Apostolova, Petya, Hechinger, Anne-Kathrin, Melchinger, Wolfgang, Fehrenbach, Kerstin, Guadamillas, Marta C., Follo, Marie, Prinz, Gabriele, Ruess, Ann-Katrin, Pfeifer, Dietmar, Angel del Pozo, Miguel, Schmitt-Graeff, Annette, Duyster, Justus, Hippen, Keli I., Blazar, Bruce R., Schachtrup, Kristina, Minguet, Susana, and Zeiser, Robert

Published
2016
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35. The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency

Author

Gámez-Díaz, Laura, August, Dietrich, Stepensky, Polina, Revel-Vilk, Shoshana, Seidel, Markus G., Noriko, Mitsuiki, Morio, Tomohiro, Worth, Austen J.J., Blessing, Jacob, Van de Veerdonk, Frank, Feuchtinger, Tobias, Kanariou, Maria, Schmitt-Graeff, Annette, Jung, Sophie, Seneviratne, Suranjith, Burns, Siobhan, Belohradsky, Bernd H., Rezaei, Nima, Bakhtiar, Shahrzad, Speckmann, Carsten, Jordan, Michael, and Grimbacher, Bodo

Published
2016
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36. Omenn syndrome associated with a functional reversion due to a somatic second-site mutation in CARD11 deficiency

Author

Fuchs, Sebastian, Rensing-Ehl, Anne, Pannicke, Ulrich, Lorenz, Myriam R., Fisch, Paul, Jeelall, Yogesh, Rohr, Jan, Speckmann, Carsten, Vraetz, Thomas, Farmand, Susan, Schmitt-Graeff, Annette, Krüger, Marcus, Strahm, Brigitte, Henneke, Philipp, Enders, Anselm, Horikawa, Keisuke, Goodnow, Christopher, Schwarz, Klaus, and Ehl, Stephan

Published
2015
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37. Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Author

Prestipino, Alessandro, Emhardt, Alica J., Aumann, Konrad, O’Sullivan, David, Gorantla, Sivahari P., Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S., Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian, Ehl, Stephan, Hartl, Frederike A., Minguet, Susana, Miething, Cornelius, Heidel, Florian H., Kröger, Nicolaus, Triviai, Ioanna, Brummer, Tilman, Finke, Jürgen, Illert, Anna L., Ruggiero, Eliana, Bonini, Chiara, Duyster, Justus, Pahl, Heike L., Lane, Steven W., Hill, Geoffrey R., Blazar, Bruce R., von Bubnoff, Nikolas, Pearce, Erika L., and Zeiser, Robert

Published
2018
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40. B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Author

Veenstra, Rachelle G., Flynn, Ryan, Kreymborg, Katharina, McDonald-Hyman, Cameron, Saha, Asim, Taylor, Patricia A., Osborn, Mark J., Panoskaltsis-Mortari, Angela, Schmitt-Graeff, Annette, Lieberknecht, Elisabeth, Murphy, William J., Serody, Jonathan S., Munn, David H., Freeman, Gordon J., Allison, James P., Mak, Tak W., van den Brink, Marcel, Zeiser, Robert, and Blazar, Bruce R.

Published
2015
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41. The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Author

Reichenbach, Dawn K., Schwarze, Vincent, Matta, Benjamin M., Tkachev, Victor, Lieberknecht, Elisabeth, Liu, Quan, Koehn, Brent H., Pfeifer, Dietmar, Taylor, Patricia A., Prinz, Gabriele, Dierbach, Heide, Stickel, Natalie, Beck, Yvonne, Warncke, Max, Junt, Tobias, Schmitt-Graeff, Annette, Nakae, Susumu, Follo, Marie, Wertheimer, Tobias, Schwab, Lukas, Devlin, Jason, Watkins, Simon C., Duyster, Justus, Ferrara, James L.M., Turnquist, Heth R., Zeiser, Robert, and Blazar, Bruce R.

Published
2015
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43. Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling

Author

Rückert, Tamina, primary, Andrieux, Geoffroy, additional, Boerries, Melanie, additional, Hanke-Müller, Kathrin, additional, Woessner, Nadine M., additional, Doetsch, Stephanie, additional, Schell, Christoph, additional, Aumann, Konrad, additional, Kolter, Julia, additional, Schmitt-Graeff, Annette, additional, Schiff, Marcel, additional, Braun, Lukas M., additional, Haring, Eileen, additional, Kissel, Sandra, additional, Siranosian, Benjamin A., additional, Bhatt, Ami S., additional, Nordkild, Peter, additional, Wehkamp, Jan, additional, Jensen, Benjamin A. H., additional, Minguet, Susana, additional, Duyster, Justus, additional, Zeiser, Robert, additional, and Köhler, Natalie, additional

Published
2022
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47. T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma

Author

Barsch, Maryam, primary, Salié, Henrike, additional, Schlaak, Alexandra Emilia, additional, Zhang, Zhen, additional, Hess, Moritz, additional, Mayer, Lena Sophie, additional, Tauber, Catrin, additional, Otto-Mora, Patricia, additional, Ohtani, Takuya, additional, Nilsson, Tobias, additional, Wischer, Lara, additional, Winkler, Frances, additional, Manne, Sasikant, additional, Rech, Andrew, additional, Schmitt-Graeff, Annette, additional, Bronsert, Peter, additional, Hofmann, Maike, additional, Neumann-Haefelin, Christoph, additional, Boettler, Tobias, additional, Fichtner-Feigl, Stefan, additional, van Boemmel, Florian, additional, Berg, Thomas, additional, Rimassa, Lorenza, additional, Di Tommaso, Luca, additional, Saeed, Anwaar, additional, D’Alessio, Antonio, additional, Pinato, David J., additional, Bettinger, Dominik, additional, Binder, Harald, additional, John Wherry, E., additional, Schultheiss, Michael, additional, Thimme, Robert, additional, and Bengsch, Bertram, additional

Published
2022
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48. Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer

Author

Taromi, Sanaz, primary, Firat, Elke, additional, Simonis, Alexander, additional, Braun, Lukas M., additional, Apostolova, Petya, additional, Elze, Mirjam, additional, Passlick, Bernward, additional, Schumacher, Alicia, additional, Lagies, Simon, additional, Frey, Anna, additional, Schmitt-Graeff, Annette, additional, Burger, Meike, additional, Schmittlutz, Katrin, additional, Follo, Marie, additional, von Elverfeldt, Dominik, additional, Zhu, Xuekai, additional, Kammerer, Bernd, additional, Diederichs, Sven, additional, Duyster, Justus, additional, Manz, Markus G., additional, Niedermann, Gabriele, additional, and Zeiser, Robert, additional

Published
2022
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49. Retraction notice to “Enhanced AC133-specific CAR T cell therapy induces durable remissions in mice with metastatic small cell lung cancer” [Canc. Lett. 520 (2021) 385–399]

Author

Taromi, Sanaz, primary, Firat, Elke, additional, Simonis, Alexander, additional, Braun, Lukas M., additional, Apostolova, Petya, additional, Elze, Mirjam, additional, Passlick, Bernward, additional, Schumacher, Alicia, additional, Lagies, Simon, additional, Frey, Anna, additional, Schmitt-Graeff, Annette, additional, Burger, Meike, additional, Schmittlutz, Katrin, additional, Follo, Marie, additional, von Elverfeldt, Dominik, additional, Zhu, Xuekai, additional, Kammerer, Bernd, additional, Diederichs, Sven, additional, Duyster, Justus, additional, Manz, Markus G., additional, Niedermann, Gabriele, additional, and Zeiser, Robert, additional

Published
2022
Full Text
View/download PDF

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