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28 results on '"Schmittling, Robert J."'

1. Supplementary Data from Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

Author

Batich, Kristen A., primary, Reap, Elizabeth A., primary, Archer, Gary E., primary, Sanchez-Perez, Luis, primary, Nair, Smita K., primary, Schmittling, Robert J., primary, Norberg, Pam, primary, Xie, Weihua, primary, Herndon, James E., primary, Healy, Patrick, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell, primary, Vlahovic, Gordana, primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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2. Data from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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3. Table S2 from A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Author

Gedeon, Patrick C., primary, Schaller, Teilo H., primary, Chitneni, Satish K., primary, Choi, Bryan D., primary, Kuan, Chien-Tsun, primary, Suryadevara, Carter M., primary, Snyder, David J., primary, Schmittling, Robert J., primary, Szafranski, Scott E., primary, Cui, Xiuyu, primary, Healy, Patrick N., primary, Herndon, James E., primary, McLendon, Roger E., primary, Keir, Stephen T., primary, Archer, Gary E., primary, Reap, Elizabeth A., primary, Sanchez-Perez, Luis, primary, Bigner, Darell D., primary, and Sampson, John H., primary

Published
2023
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4. Table S2 from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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5. Figure S1 from A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Author

Gedeon, Patrick C., primary, Schaller, Teilo H., primary, Chitneni, Satish K., primary, Choi, Bryan D., primary, Kuan, Chien-Tsun, primary, Suryadevara, Carter M., primary, Snyder, David J., primary, Schmittling, Robert J., primary, Szafranski, Scott E., primary, Cui, Xiuyu, primary, Healy, Patrick N., primary, Herndon, James E., primary, McLendon, Roger E., primary, Keir, Stephen T., primary, Archer, Gary E., primary, Reap, Elizabeth A., primary, Sanchez-Perez, Luis, primary, Bigner, Darell D., primary, and Sampson, John H., primary

Published
2023
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6. Figure S2 from Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., primary, Batich, Kristen A., primary, Sanchez-Perez, Luis, primary, Archer, Gary E., primary, Schmittling, Robert J., primary, Norberg, Pamela K., primary, Herndon, James E., primary, Healy, Patrick, primary, Congdon, Kendra L., primary, Gedeon, Patrick C., primary, Campbell, Olivia C., primary, Swartz, Adam M., primary, Riccione, Katherine A., primary, Yi, John S., primary, Hossain-Ibrahim, Mohammed K., primary, Saraswathula, Anirudh, primary, Nair, Smita K., primary, Dunn-Pirio, Anastasie M., primary, Broome, Taylor M., primary, Weinhold, Kent J., primary, Desjardins, Annick, primary, Vlahovic, Gordana, primary, McLendon, Roger E., primary, Friedman, Allan H., primary, Friedman, Henry S., primary, Bigner, Darell D., primary, Fecci, Peter E., primary, Mitchell, Duane A., primary, and Sampson, John H., primary

Published
2023
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10. A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Author

Gedeon, Patrick C., primary, Schaller, Teilo H., additional, Chitneni, Satish K., additional, Choi, Bryan D., additional, Kuan, Chien-Tsun, additional, Suryadevara, Carter M., additional, Snyder, David J., additional, Schmittling, Robert J., additional, Szafranski, Scott E., additional, Cui, Xiuyu, additional, Healy, Patrick N., additional, Herndon, James E., additional, McLendon, Roger E., additional, Keir, Stephen T., additional, Archer, Gary E., additional, Reap, Elizabeth A., additional, Sanchez-Perez, Luis, additional, Bigner, Darell D., additional, and Sampson, John H., additional

Published
2018
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11. Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma

Author

Reap, Elizabeth A., primary, Suryadevara, Carter M., additional, Batich, Kristen A., additional, Sanchez-Perez, Luis, additional, Archer, Gary E., additional, Schmittling, Robert J., additional, Norberg, Pamela K., additional, Herndon, James E., additional, Healy, Patrick, additional, Congdon, Kendra L., additional, Gedeon, Patrick C., additional, Campbell, Olivia C., additional, Swartz, Adam M., additional, Riccione, Katherine A., additional, Yi, John S., additional, Hossain-Ibrahim, Mohammed K., additional, Saraswathula, Anirudh, additional, Nair, Smita K., additional, Dunn-Pirio, Anastasie M., additional, Broome, Taylor M., additional, Weinhold, Kent J., additional, Desjardins, Annick, additional, Vlahovic, Gordana, additional, McLendon, Roger E., additional, Friedman, Allan H., additional, Friedman, Henry S., additional, Bigner, Darell D., additional, Fecci, Peter E., additional, Mitchell, Duane A., additional, and Sampson, John H., additional

Published
2018
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12. Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination

Author

Batich, Kristen A., primary, Reap, Elizabeth A., additional, Archer, Gary E., additional, Sanchez-Perez, Luis, additional, Nair, Smita K., additional, Schmittling, Robert J., additional, Norberg, Pam, additional, Xie, Weihua, additional, Herndon, James E., additional, Healy, Patrick, additional, McLendon, Roger E., additional, Friedman, Allan H., additional, Friedman, Henry S., additional, Bigner, Darell, additional, Vlahovic, Gordana, additional, Mitchell, Duane A., additional, and Sampson, John H., additional

Published
2017
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13. A Novel Inhibitor of STAT3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

Author

Kong, Ling-Yuan, Abou-Ghazal, Mohamed K., Wei, Jun, Chakraborty, Arup, Sun, Wei, Qiao, Wei, Fuller, Gregory N., Fokt, Izabela, Grimm, Elizabeth A., Schmittling, Robert J., Archer, Gary E., Sampson, John H., Priebe, Waldemar, and Heimberger, Amy B.

Subjects
STAT3 Transcription Factor, Brain Neoplasms, Pyridines, Melanoma, Experimental, Antineoplastic Agents, Tyrphostins, T-Lymphocytes, Regulatory, Article, Mice, Inbred C57BL, Mice, Cell Line, Tumor, Animals, Cytokines, Female
Abstract

Activation of signal transducers and activators of transcription 3 (STAT3) has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, has marked antitumor activity, even against the melanoma metastasis to brain, a site typically refractory to therapies.The antitumor activities and related mechanisms of WP1066 were investigated both in vitro on melanoma cell lines and in vivo on mice with subcutaneously syngeneic melanoma or with intracerebral melanoma tumors.WP1066 achieved an IC(50) of 1.6, 2.3, and 1.5 mumol/L against melanoma cell line A375, B16, and B16EGFRvIII, respectively. WP1066 suppressed the phosphorylation of Janus-activated kinase 2 and STAT3 (Tyr705) in these cells. Tumor growth in mice with subcutaneously established syngeneic melanoma was markedly inhibited by WP1066 compared with that in controls. Long-term survival (78 days) was observed in 80% of mice with established intracerebral syngeneic melanoma treated with 40 mg/kg of WP1066 in contrast to control mice who survived for a median of 15 days. Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-beta, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells.The antitumor cytotoxic effects of WP1066 and its ability to induce antitumor immune responses suggest that this compound has potential for the effective treatment of melanoma metastatic to brain.

Published
2008

14. EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

Author

Sampson, John H., primary, Choi, Bryan D., additional, Sanchez-Perez, Luis, additional, Suryadevara, Carter M., additional, Snyder, David J., additional, Flores, Catherine T., additional, Schmittling, Robert J., additional, Nair, Smita K., additional, Reap, Elizabeth A., additional, Norberg, Pamela K., additional, Herndon, James E., additional, Kuan, Chien-Tsun, additional, Morgan, Richard A., additional, Rosenberg, Steven A., additional, and Johnson, Laura A., additional

Published
2014
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15. Myeloablative Temozolomide Enhances CD8+ T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice

Author

Sanchez-Perez, Luis A., primary, Choi, Bryan D., additional, Archer, Gary E., additional, Cui, Xiuyu, additional, Flores, Catherine, additional, Johnson, Laura A., additional, Schmittling, Robert J., additional, Snyder, David, additional, Herndon, James E., additional, Bigner, Darell D., additional, Mitchell, Duane A., additional, and Sampson, John H., additional

Published
2013
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16. A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

Author

Sampson, John H., primary, Schmittling, Robert J., additional, Archer, Gary E., additional, Congdon, Kendra L., additional, Nair, Smita K., additional, Reap, Elizabeth A., additional, Desjardins, Annick, additional, Friedman, Allan H., additional, Friedman, Henry S., additional, Herndon, James E., additional, Coan, April, additional, McLendon, Roger E., additional, Reardon, David A., additional, Vredenburgh, James J., additional, Bigner, Darell D., additional, and Mitchell, Duane A., additional

Published
2012
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17. Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans

Author

Mitchell, Duane A., primary, Cui, Xiuyu, additional, Schmittling, Robert J., additional, Sanchez-Perez, Luis, additional, Snyder, David J., additional, Congdon, Kendra L., additional, Archer, Gary E., additional, Desjardins, Annick, additional, Friedman, Allan H., additional, Friedman, Henry S., additional, Herndon, James E., additional, McLendon, Roger E., additional, Reardon, David A., additional, Vredenburgh, James J., additional, Bigner, Darell D., additional, and Sampson, John H., additional

Published
2011
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18. Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

Author

Sampson, John H., primary, Heimberger, Amy B., additional, Archer, Gary E., additional, Aldape, Kenneth D., additional, Friedman, Allan H., additional, Friedman, Henry S., additional, Gilbert, Mark R., additional, Herndon, James E., additional, McLendon, Roger E., additional, Mitchell, Duane A., additional, Reardon, David A., additional, Sawaya, Raymond, additional, Schmittling, Robert J., additional, Shi, Weiming, additional, Vredenburgh, James J., additional, and Bigner, Darell D., additional

Published
2010
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20. A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

Author

Kong, Ling-Yuan, primary, Abou-Ghazal, Mohamed K., additional, Wei, Jun, additional, Chakraborty, Arup, additional, Sun, Wei, additional, Qiao, Wei, additional, Fuller, Gregory N., additional, Fokt, Izabela, additional, Grimm, Elizabeth A., additional, Schmittling, Robert J., additional, Archer, Gary E., additional, Sampson, John H., additional, Priebe, Waldemar, additional, and Heimberger, Amy B., additional

Published
2008
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21. The Role of Tregs in Human Glioma Patients and their Inhibition with a Novel STAT-3 Inhibitor

Author

Abou-Ghazal, Mohamed, primary, Kong, Ling-Yuan, additional, Reina-Ortiz, Chantal, additional, Yang, David S., additional, Wei, Jun, additional, Qiao, Wei, additional, Schmittling, Robert J., additional, Archer, Gary E., additional, Fuller, Gregory N., additional, Sampson, John H., additional, Priebe, Waldemar, additional, and Heimberger, Amy B., additional

Published
2008
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22. Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers

Author

Learn, Chris A., primary, Fecci, Peter E., additional, Schmittling, Robert J., additional, Xie, Weihua, additional, Karikari, Isaac, additional, Mitchell, Duane A., additional, Archer, Gary E., additional, Wei, ZhengZheng, additional, Dressman, Holly, additional, and Sampson, John H., additional

Published
2006
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26. Myeloablative Temozolomide Enhances CD8+ T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice.

Author

Sanchez-Perez, Luis A., Choi, Bryan D., Archer, Gary E., Cui, Xiuyu, Flores, Catherine, Johnson, Laura A., Schmittling, Robert J., Snyder, David, Herndon II, James E., Bigner, Darell D., Mitchell, Duane A., and Sampson, John H.

Subjects
BRAIN tumor treatment, IMIDAZOLES, T cells, ALKYLATING agents, BRAIN metastasis, CANCER immunotherapy, CANCER vaccines, CANCER chemotherapy, LABORATORY mice
Abstract

Temozolomide (TMZ) is an alkylating agent shown to prolong survival in patients with high grade glioma and is routinely used to treat melanoma brain metastases. A prominent side effect of TMZ is induction of profound lymphopenia, which some suggest may be incompatible with immunotherapy. Conversely, it has been proposed that recovery from chemotherapy-induced lymphopenia may actually be exploited to potentiate T-cell responses. Here, we report the first demonstration of TMZ as an immune host-conditioning regimen in an experimental model of brain tumor and examine its impact on antitumor efficacy of a well-characterized peptide vaccine. Our results show that high-dose, myeloablative (MA) TMZ resulted in markedly reduced CD4+, CD8+ T-cell and CD4+Foxp3+ TReg counts. Adoptive transfer of naïve CD8+ T cells and vaccination in this setting led to an approximately 70-fold expansion of antigen-specific CD8+ T cells over controls. Ex vivo analysis of effector functions revealed significantly enhanced levels of pro-inflammatory cytokine secretion from mice receiving MA TMZ when compared to those treated with a lower lymphodepletive, non-myeloablative (NMA) dose. Importantly, MA TMZ, but not NMA TMZ was uniquely associated with an elevation of endogenous IL-2 serum levels, which we also show was required for optimal T-cell expansion. Accordingly, in a murine model of established intracerebral tumor, vaccination-induced immunity in the setting of MA TMZ–but not lymphodepletive, NMA TMZ–led to significantly prolonged survival. Overall, these results may be used to leverage the side-effects of a clinically-approved chemotherapy and should be considered in future study design of immune-based treatments for brain tumors. [ABSTRACT FROM AUTHOR]

Published
2013
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28. The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor.

Author

Heimberger AB, Kong LY, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Wei J, Qiao W, Schmittling RJ, Archer GE, Sampson JH, Hiraoka N, Priebe W, Fuller GN, and Sawaya R

Subjects
Animals, Brain Neoplasms mortality, Cell Culture Techniques, Cohort Studies, Disease Models, Animal, Female, Forkhead Transcription Factors, Glioma mortality, Humans, Male, Mice, Mice, Inbred C57BL, Retrospective Studies, STAT3 Transcription Factor antagonists & inhibitors, Survival Rate, T-Lymphocytes, Regulatory physiology, Brain Neoplasms pathology, Brain Neoplasms therapy, Glioma pathology, Glioma therapy, Pyridines pharmacology, T-Lymphocytes, Regulatory drug effects, Tyrphostins pharmacology
Published
2009

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