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Background: Dual-energy computed tomography (DECT) is a noninvasive diagnostic tool for gouty arthritis. This study aimed to compare two postprocessing techniques for monosodium urate (MSU) detection: conventional two-material decomposition and material map-based decomposition., Methods: A raster phantom and an ex vivo biophantom, embedded with four different MSU concentrations, were scanned in two high-end CT scanners. Scanner 1 used the conventional postprocessing method while scanner 2 employed the material map approach. Volumetric analysis was performed to determine MSU detection, and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), were computed., Results: The material map-based method demonstrated superior MSU detection. Specifically, scanner 2 yielded total MSU volumes of 5.29 ± 0.28 mL and 4.52 ± 0.29 mL (mean ± standard deviation) in the raster and biophantom, respectively, versus 2.35 ± 0.23 mL and 1.15 ± 0.17 mL for scanner 1. Radiation dose correlated positively with detection for the conventional scanner, while there was no such correlation for the material map-based decomposition method in the biophantom. Despite its higher detection rate, material map-based decomposition was inferior in terms of SNR, CNR, and artifacts., Conclusion: While material map-based decomposition resulted in superior MSU detection, it is limited by challenges such as increased artifacts. Our findings highlight the potential of this method for gout diagnosis while underscoring the need for further research to enhance its clinical reliability., Relevance Statement: Advanced postprocessing such as material-map-based two-material decomposition might improve the sensitivity for gouty arthritis in clinical practice, thus, allowing for lower radiation doses or better sensitivity for gouty tophi., Key Points: Dual-energy CT showed limited sensitivity for tophi with low MSU concentrations. Materiel-map-based decomposition increased sensitivity compared to conventional two-material decomposition. The advantages of material-map-based decomposition outweigh lower image quality and increased artifact load., (© 2024. The Author(s).)

Six hundred forty growing-finishing pigs (initial BW = 23.2 +/- 4.8 kg) were used in a 12-wk study (final BW = 95.5 +/- 10.2 kg) to quantify the effects of group size (10, 20, 40, and 80 pigs/pen) on performance, tail biting, and use of widely distributed feed resources. One single-space wet/dry feeder was provided for every 10 pigs, and floor allowance was 0.76 m2/pig in all treatment groups. Weight gain and feed intake were measured every 2 wk. At weighing, a tail-biting injury score was given to each pig. Blood samples were collected and analyzed for neutrophil:lymphocyte ratio before regrouping at the beginning of the experiment, 24 to 48 h after regrouping, and on the last day of each trial. The use of feeders by individual pigs was assessed by behavioral observations. Average daily gain for the entire 12-wk trial did not differ among group sizes (861, 873, 854, and 845 g/d for groups of 10, 20, 40, and 80, respectively; P > 0.10). During the first 2 wk, ADG was lower for pigs in groups of 40 (554 g/d) than pigs in groups of 10 (632 g/d; P < 0.05), but not pigs in groups of 20 or 80 (602 and 605 g/d, respectively). Average daily feed intake, feed efficiency, and variability in final BW within a pen also did not differ among group sizes. Tail-biting injury scores increased throughout the study, but did not differ among group sizes. Similar proportions of pigs were removed from the trial for health reasons, primarily due to tail biting, in all treatments. Individual pigs in each group size ate from most, if not all, of the feeders in the pen. There was no evidence of spatial subgrouping within the larger groups. The results suggest that housing growing-finishing pigs in groups of up to 80 pigs is not detrimental to productivity and health if space allowance is adequate and feed resources are evenly distributed.