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1. Higher TIER bumble bees and solitary bees recommendations for a semi-field experimental design

Author

Allan, Matthew J., Alscher, Annika, Amsel, Kristin, Classen, Christian, Cornement, Magdaléna, Elston, Charlotte, Exeler, Nina, Franke, Lea, Frommberger, Malte, Giffard, Hervé, Guerola, Juan Sorlí, Hecht-Rost, Sabine, Hodapp, Bettina, Hotopp, Ines, Jenkins, Carole, Jütte, Tobias, Kimmel, Stefan, Klein, Olaf, Kullmann, Britta, Lückmann, Johannes, Persigehl, Markus, Roessink, Ivo, Schneider, Christof, Schnurr, Alexander, Tänzler, Verena, and van der Steen, Jozef J.M.

Subjects
semi-field testing, non-apis bees, bumble bees, solitary bees, Agriculture, Botany, QK1-989
Abstract

The publication of the proposed EFSA risk assessment guidance document of plant protection products for pollinators highlighted that there are no study designs for non-Apis pollinators available. Since no official guidelines exist for semi-field testing at present, protocols were proposed by the ICPPR non-Apis working group and two years of ring-testing were conducted in 2016 and 2017 to develop a general test set-up. The ringtest design was based on the draft EFSA guidance document, OEPP/EPPO Guideline No. 170 and results of discussions regarding testing solitary bees and bumble bees during the meetings of the ICPPR non-Apis workgroup. Ring-tests were conducted with two different test organisms, one representative of a social bumble bee species (Bombus terrestris L; Hymenoptera, Apidae) and one representative of a solitary bee species (Osmia bicornis L; Hymenoptera, Megachilidae). The species are common species in Europe, commercially available and widely used for pollination services. Several laboratories participated in the higher-tier ring tests. 15 semi-field tests were conducted with bumble bees and 16 semi-field tests were done with solitary bees in 2016 and 2017. Two treatment groups were always included in the ringtests: an untreated control (water treated) and the treatment with dimethoate as a toxic reference item (optional other i.e. brood-affecting substances fenoxycarb or diflubenzuron). The toxic reference items were chosen based on their mode of action and long term experience in honey bee testing. A summary of the ringtest results will be given and the recommendations for the two semi-field test designs will be presented.

Published
2020
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2. Evaluation of honey bee larvae data: sensitivity to PPPs and impact analysis of EFSA Bee GD

Author

Lückmann, Johannes, Becker, Roland, Miles, Mark, Alix, Anne, Dinter, Axel, Kroder, Stefan, Pilling, Ed, Ruddle, Natalie, Schneider, Christof, Sharples, Amanda, and Oger, Laurent

Subjects
honey bees, bumble bees, solitary bees, larvae, impact analysis, risk assessment, efsa bee gd, Agriculture, Botany, QK1-989
Abstract

In addition to other assessments, the EFSA bee guidance document (2013) requires the risk assessment of plant protection products on honey bee larvae. At the time the EFSA GD was finalized, no data on honey bee larvae were available due to absence of suitable methods. That is why in 2013 the European Crop Protection Association (ECPA) perfomed an impact analysis of the new EFSA risk assessment, using extrapolated endpoints derived from acute oral honey bee endpoints. Today, a number of honey bee larvae toxicity studies (138 active substances or formulated products) have been conducted according to the newly developed testing methods for single exposure (OECD TG 237) repeated exposure studies until the end of the larval development (D7/D8) and repeated exposure testing (OECD GD 239) until adult hatch (D22). These experimental data have been used to determine the ‘pass rates’ for 215 worst case uses (72 fungicide spray and solid uses, 91 herbicide spray uses, incl. 8 PGR uses and in total 52 insecticide spray and solid uses, incl. 2 nematicide and 3 IGR uses) according to the EFSA Bee GD and to compare with the original ECPA impact analysis. As standardized test methods for non- Apis bees larvae were not available, risk assessment according to EFSA for bumblebees and solitary bees based on the honey bee endpoint as surrogate corrected by a safety factor of 10. Morevoer, the sensitivity of the NOEDs at D8 and D22 in repeated exposure (D 22) studies were analysed. Overall, the toxicity of fungicides and herbicides to honey bee larvae (expressed as means and medians of NOED and LD50 values) was moderate to low, while insecticides as expected displayed stronger toxicity. Moreover, the endpoints for herbicides were on average a factor of 2 higher than fungicides which ranges within the normal biological variability (factor of 3). In addition, it is unclear, if the difference is related to a slightly higher toxicity or other factors like different physical chemical properties (e.g. lower solubility). For insecticides, toxicity was about 125 (based on medians) and 6 to 8 (based on means) times higher than herbicides. In the screening risk assessment according to EFSA Bee GD the majority of fungicide (83.3%) and herbicide (95.6%) uses passed the risk assessment for larvae; whereas, for all insecticide uses thr pass rate was about 29%. In the Tier 1 risk assessment, these pass rates slightly increased and were even higher in the ‘treated crop’ and ‘weed in the field’ scenarios for fungicide and herbicide uses, almost being 100%. Pass rates for insecticide uses did not improve very much and amounted to be about 42% for both scenarios. When basing the risk assessment of bumblebee and solitary bee larvae on 1/10th of the honey bee larval endpoint, the majority of active substances and their respective products will fail the screening (overall about 96%) and Tier 1 risk assessment (overall about 90%). Alternative risk assessment approaches proposed by ECPA (e.g. following the EPPO approach; ECPA Option 1 using refinement options and more representative assumptions) or comparing an assummed exposure concentration to the NOEC (ECPA Option 2) led to a slight increase (Option 1) or even no differences in the pass rates (Option 2a) compared to EFSA Tier 1 risk assessment. Thus both, the standard risk assessment according to the EFSA Bee GD as well as the alternative ECPA Option 1 and 2 result in a clear distinction between products with high toxicity (insecticides) vs. non-toxic products (herbicides and fungicides) for the honey bee risk assessment. The sensitivity analysis of repeated exposure studies according OECD GD 239 indicated that in most cases toxicity did not increase during the pupation period between D8 and D22. Thus, the larval growing period between D3 and D8 represents the most sensitive period of the pre-imaginal development.

Published
2020
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3. Correlation of Structural and Magnetic Properties of RFeO3 (R=Dy, Lu)

Author

Biswas, Banani, Naumov, Pavel, Motti, Federico, Hautle, Patrick, Bartkowiak, Marek, Pomjakushina, Ekaterina V., Stuhr, Uwe, Fuchs, Dirk, Lippert, Thomas, and Schneider, Christof W.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract

In orthoferrites the rare-earth (R) ion has a big impact on structural and magnetic properties in particular the ionic size influences the octahedral tilt and the R3+- Fe3+ interaction modifies properties like the spin reorientation. Growth induced strain in thin films is another means to modify materials properties since the sign of strain affects the bond length and therefore directly the orbital interaction. Our study focuses on epitaxially grown (010) oriented DyFeO3 and LuFeO3 thin films, thereby investigating the impact of compressive lattice strain on the magnetically active Dy3+ and magnetically inactive Lu3+ compared to uniaxially strained single crystal DyFeO3. The DyFeO3 films exhibits a shift of more than 20K in spin-reorientation temperatures, maintain the antiferromagnetic {\Gamma}4 phase of the Fe-lattice below the spin reorientation, and show double step hysteresis loops for both in-plane directions between 5 K and 390 K. This is the signature of an Fe-spin induced ferromagnetic Dy3+ lattice above the N\'eel temperature of the Dy. The observed shift in the film spin reorientation temperatures vs lattice strain is in good agreement with isostatic single crystal neutron diffraction experiments with a rate of 2 K/ kbar bar., Comment: 18 pages, 5 Figures

Published
2024

4. Summary of an ICPPR Non-Apis workshop – Subgroup higher tier (bumble bees and solitary bees) with recommendations for a semi-field experimental design

Author

Knaebe, Silvio, Alscher, Annika, Classen, Christian, Exeler, Nina, Franke, Lea, Fricke, Julian, Frommberger, Malte, Guerola, Juan Sorlí, Hecht-Rost, Sabine, Kimmel, Stefan, Klein, Olaf, Lueckmann, Johannes, Molitor, Claire, Peters, Britta, and Schneider, Christof

Subjects
Agriculture, Botany, QK1-989
Published
2018
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7. Report of the activities of the ICPPR Bee Brood Working Group

Author

Allan, Matthew J., Barth, Markus, Becker, Roland, Bocksch, Sigrun, Cornement, Magdaléna, Eckert, Jakob H., Giffard, Hervé, Hodapp, Bettina, Jeker, Lukas, Kimmel, Stefan, Lückmann, Johannes, Persigehl, Markus, Pilling, Ed, Ruddle, Natalie, Sabo, Rastislav, Schneider, Christof, Schmitzer, Stephan, Sultan, Maryam, Tänzler, Verena, and Wilkins, Selwyn

Subjects
Agriculture, Botany, QK1-989
Published
2020
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8. Progress on the Osmia acute oral test - findings of the ICPPR Non-Apis subgroup solitary bee laboratory testing

Author

Roessink, Ivo, Hanewald, Nicole, Schneider, Christof, Quambusch, Anja, Exeler, Nina, Cabrera, Ana R., Molitor, Anna Maria, Tänzler, Verena, Hodapp, Bettina, Albrecht, Matthias, Brandt, Annely, Vinall, Steven, Rathke, Anne-Kathrin, Giffard, Hervé, Soler, Eugenia, Schnurr, Alexander, Patnaude, Michael, Couture, Elodie, and Lehman, David

Subjects
Agriculture, Botany, QK1-989
Published
2020
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13. Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial

Author

Al-Sawaf, Othman, Ligtvoet, Rudy, Robrecht, Sandra, Stumpf, Janina, Fink, Anna-Maria, Tausch, Eugen, Schneider, Christof, Boettcher, Sebastian, Mikusko, Martin, Ritgen, Matthias, Schetelig, Johannes, von Tresckow, Julia, Vehling-Kaiser, Ursula, Gaska, Tobias, Wendtner, Clemens Martin, Chapuy, Bjoern, Fischer, Kirsten, Kreuzer, Karl-Anton, Stilgenbauer, Stephan, Staber, Philipp, Niemann, Carsten, Hallek, Michael, and Eichhorst, Barbara

Published
2024
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14. Role of Dy on the magnetic properties of orthorhombic DyFeO3

Author

Biswas, Banani, Michel, Veronica F., Fjellvag, Oystein S., Bimashofer, Gesara, Dobeli, Max, Jambor, Michal, Keller, Lukas, Muller, Elisabeth, Ukleev, Victor, Pomjakushina, Ekaterina V., Singh, Deepak, Stuhr, Uwe, Vaz, Carlos A. F., Lippert, Thomas, and Schneider, Christof W.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

Orthoferrites are a class of magnetic materials with a magnetic ordering temperature above 600 K, predominant G-type antiferromagnetic ordering of the Fe-spin system and, depending on the rare-earth ion, a spin reorientation of the Fe spin taking place at lower temperatures. DyFeO3 is of particular interest since the spin reorientation is classified as a Morin transition with the transition temperature depending strongly on the Dy-Fe interaction. Here, we report a detailed study of the magnetic and structural properties of microcrystalline DyFeO3 powder and bulk single crystal using neutron diffraction and magnetometry between 1.5 and 450 K. We find that, while the magnetic properties of the single crystal are largely as expected, the powder shows strongly modified magnetic properties, including a modified spin reorientation and a smaller Dy-Fe interaction energy of the order of 10 {\mu}eV. Subtle structural differences between powder and single crystal show that they belong to distinct magnetic space groups. In addition, the Dy ordering at 2 K in the powder is incommensurate, with a modulation vector of 0.0173(5) c*, corresponding to a periodicity of ~58 unit cells., Comment: contains supplementary material

Published
2022
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15. Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

Author

Parry, Erin M, Leshchiner, Ignaty, Guièze, Romain, Johnson, Connor, Tausch, Eugen, Parikh, Sameer A, Lemvigh, Camilla, Broséus, Julien, Hergalant, Sébastien, Messer, Conor, Utro, Filippo, Levovitz, Chaya, Rhrissorrakrai, Kahn, Li, Liang, Rosebrock, Daniel, Yin, Shanye, Deng, Stephanie, Slowik, Kara, Jacobs, Raquel, Huang, Teddy, Li, Shuqiang, Fell, Geoff, Redd, Robert, Lin, Ziao, Knisbacher, Binyamin A, Livitz, Dimitri, Schneider, Christof, Ruthen, Neil, Elagina, Liudmila, Taylor-Weiner, Amaro, Persaud, Bria, Martinez, Aina, Fernandes, Stacey M, Purroy, Noelia, Anandappa, Annabelle J, Ma, Jialin, Hess, Julian, Rassenti, Laura Z, Kipps, Thomas J, Jain, Nitin, Wierda, William, Cymbalista, Florence, Feugier, Pierre, Kay, Neil E, Livak, Kenneth J, Danysh, Brian P, Stewart, Chip, Neuberg, Donna, Davids, Matthew S, Brown, Jennifer R, Parida, Laxmi, Stilgenbauer, Stephan, Getz, Gad, and Wu, Catherine J

Subjects
Cancer, Rare Diseases, Lymphoma, Genetics, Hematology, Human Genome, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Serine-Arginine Splicing Factors, Medical and Health Sciences, Immunology
Abstract

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we computationally deconvoluted admixtures of CLL and RS cells from 52 patients with RS, evaluating paired CLL-RS whole-exome sequencing data. We discovered RS-specific somatic driver mutations (including IRF2BP2, SRSF1, B2M, DNMT3A and CCND3), recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which were confirmed in 45 independent RS cases and in an external set of RS whole genomes. Through unsupervised clustering, clonally related RS was largely distinct from diffuse large B cell lymphoma. We distinguished pathways that were dysregulated in RS versus CLL, and detected clonal evolution of transformation at single-cell resolution, identifying intermediate cell states. Our study defines distinct molecular subtypes of RS and highlights cell-free DNA analysis as a potential tool for early diagnosis and monitoring.

Published
2023

16. Molecular map of chronic lymphocytic leukemia and its impact on outcome

Author

Knisbacher, Binyamin A, Lin, Ziao, Hahn, Cynthia K, Nadeu, Ferran, Duran-Ferrer, Martí, Stevenson, Kristen E, Tausch, Eugen, Delgado, Julio, Barbera-Mourelle, Alex, Taylor-Weiner, Amaro, Bousquets-Muñoz, Pablo, Diaz-Navarro, Ander, Dunford, Andrew, Anand, Shankara, Kretzmer, Helene, Gutierrez-Abril, Jesus, López-Tamargo, Sara, Fernandes, Stacey M, Sun, Clare, Sivina, Mariela, Rassenti, Laura Z, Schneider, Christof, Li, Shuqiang, Parida, Laxmi, Meissner, Alexander, Aguet, François, Burger, Jan A, Wiestner, Adrian, Kipps, Thomas J, Brown, Jennifer R, Hallek, Michael, Stewart, Chip, Neuberg, Donna S, Martín-Subero, José I, Puente, Xose S, Stilgenbauer, Stephan, Wu, Catherine J, Campo, Elias, and Getz, Gad

Subjects
Hematology, Clinical Research, Cancer, Human Genome, Rare Diseases, Biotechnology, Genetics, Lymphoma, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Immunoglobulin Variable Region, Mutation, Prognosis, Genomics, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymphocytic leukemia (CLL), a B cell neoplasm with variable natural history that is conventionally categorized into two subtypes distinguished by extent of somatic mutations in the heavy-chain variable region of immunoglobulin genes (IGHV). To build the 'CLL map,' we integrated genomic, transcriptomic and epigenomic data from 1,148 patients. We identified 202 candidate genetic drivers of CLL (109 new) and refined the characterization of IGHV subtypes, which revealed distinct genomic landscapes and leukemogenic trajectories. Discovery of new gene expression subtypes further subcategorized this neoplasm and proved to be independent prognostic factors. Clinical outcomes were associated with a combination of genetic, epigenetic and gene expression features, further advancing our prognostic paradigm. Overall, this work reveals fresh insights into CLL oncogenesis and prognostication.

Published
2022

17. Terahertz displacive excitation of a coherent Raman-active phonon in V$_2$O$_3$

Author

Giorgianni, Flavio, Udina, Mattia, Cea, Tommaso, Paris, Eugenio, Caputo, Marco, Radovic, Milan, Boie, Larissa, Sakai, Joe, Schneider, Christof W., and Johnson, Steven Lee

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Nonlinear processes involving frequency-mixing of light fields set the basis for ultrafast coherent spectroscopy of collective modes in solids. In certain semimetals and semiconductors, generation of coherent phonon modes can occur by a displacive force on the lattice at the difference-frequency mixing of a laser pulse excitation on the electronic system. Here, as a low-frequency counterpart of this process, we demonstrate that coherent phonon excitations can be induced by the sum-frequency components of an intense terahertz light field, coupled to intraband electronic transitions. This nonlinear process leads to charge-coupled coherent dynamics of Raman-active phonon modes in the strongly correlated metal V$_2$O$_3$. Our results show a new up-conversion pathway for the optical control of Raman-active modes in solids mediated by terahertz-driven electronic excitation., Comment: 15 pages; 11 figures

Published
2022

18. T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Author

Roessner, Philipp M., Seufert, Isabelle, Chapaprieta, Vicente, Jayabalan, Ruparoshni, Briesch, Hannah, Massoni-Badosa, Ramon, Boskovic, Pavle, Benckendorff, Julian, Roider, Tobias, Arseni, Lavinia, Coelho, Mariana, Chakraborty, Supriya, Vaca, Alicia M., Sivina, Mariela, Muckenhuber, Markus, Rodriguez-Rodriguez, Sonia, Bonato, Alice, Herbst, Sophie A., Zapatka, Marc, Sun, Clare, Kretzmer, Helene, Naake, Thomas, Bruch, Peter-Martin, Czernilofsky, Felix, ten Hacken, Elisa, Schneider, Martin, Helm, Dominic, Yosifov, Deyan Y., Kauer, Joseph, Danilov, Alexey V., Bewarder, Moritz, Heyne, Kristina, Schneider, Christof, Stilgenbauer, Stephan, Wiestner, Adrian, Mallm, Jan-Philipp, Burger, Jan A., Efremov, Dimitar G., Lichter, Peter, Dietrich, Sascha, Martin-Subero, José I., Rippe, Karsten, and Seiffert, Martina

Published
2024
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19. Acalabrutinib, venetoclax, and obinutuzumab in relapsed/refractory CLL: final efficacy and ctDNA analysis of the CLL2-BAAG trial

Author

Fürstenau, Moritz, Giza, Adam, Weiss, Jonathan, Kleinert, Fanni, Robrecht, Sandra, Franzen, Fabian, Stumpf, Janina, Langerbeins, Petra, Al-Sawaf, Othman, Simon, Florian, Fink, Anna-Maria, Schneider, Christof, Tausch, Eugen, Schetelig, Johannes, Dreger, Peter, Böttcher, Sebastian, Fischer, Kirsten, Kreuzer, Karl-Anton, Ritgen, Matthias, Schilhabel, Anke, Brüggemann, Monika, Stilgenbauer, Stephan, Eichhorst, Barbara, Hallek, Michael, and Cramer, Paula

Published
2024
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20. Reassessing the chronic lymphocytic leukemia International Prognostic Index in the era of targeted therapies

Author

Langerbeins, Petra, Giza, Adam, Robrecht, Sandra, Cramer, Paula, von Tresckow, Julia, Al-Sawaf, Othman, Fink, Anna Maria, Fürstenau, Moritz, Kutsch, Nadine, Simon, Florian, Goede, Valentin, Hoechstetter, Manuela, Niemann, Carsten Utoft, da Cunha-Bang, Caspar, Kater, Arnon, Dubois, Julie, Gregor, Michael, Staber, Philipp Bernhard, Tausch, Eugen, Schneider, Christof, Stilgenbauer, Stephan, Eichhorst, Barbara, Fischer, Kirsten, and Hallek, Michael

Published
2024
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21. First-line venetoclax combinations versus chemoimmunotherapy in fit patients with chronic lymphocytic leukaemia (GAIA/CLL13): 4-year follow-up from a multicentre, open-label, randomised, phase 3 trial

Author

Fürstenau, Moritz, Kater, Arnon P, Robrecht, Sandra, von Tresckow, Julia, Zhang, Can, Gregor, Michael, Thornton, Patrick, Staber, Philipp B, Tadmor, Tamar, Lindström, Vesa, Juliusson, Gunnar, Janssens, Ann, Levin, Mark-David, da Cunha-Bang, Caspar, Schneider, Christof, Goldschmidt, Neta, Vandenberghe, Elisabeth, Rossi, Davide, Benz, Rudolf, Nösslinger, Thomas, Heintel, Daniel, Poulsen, Christian B, Christiansen, Ilse, Frederiksen, Henrik, Enggaard, Lisbeth, Posthuma, Eduardus F M, Issa, Djamila E, Visser, Hein P J, Bellido, Mar, Kutsch, Nadine, Dürig, Jan, Stehle, Alexander, Vöhringer, Matthias, Böttcher, Sebastian, Schulte, Clemens, Simon, Florian, Fink, Anna-Maria, Fischer, Kirsten, Holmes, Emily E, Kreuzer, Karl-Anton, Ritgen, Matthias, Brüggemann, Monika, Tausch, Eugen, Stilgenbauer, Stephan, Hallek, Michael, Niemann, Carsten U, and Eichhorst, Barbara

Published
2024
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22. Author Correction: Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Author

Al-Sawaf, Othman, Zhang, Can, Jin, Hyun Yong, Robrecht, Sandra, Choi, Yoonha, Balasubramanian, Sandhya, Kotak, Alex, Chang, Yi Meng, Fink, Anna Maria, Tausch, Eugen, Schneider, Christof, Ritgen, Matthias, Kreuzer, Karl-Anton, Chyla, Brenda, Paulson, Joseph N., Pallasch, Christian P., Frenzel, Lukas P., Peifer, Martin, Eichhorst, Barbara, Stilgenbauer, Stephan, Jiang, Yanwen, Hallek, Michael, and Fischer, Kirsten

Published
2023
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23. Transcriptomic profiles and 5-year results from the randomized CLL14 study of venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab in chronic lymphocytic leukemia

Author

Al-Sawaf, Othman, Zhang, Can, Jin, Hyun Yong, Robrecht, Sandra, Choi, Yoonha, Balasubramanian, Sandhya, Kotak, Alex, Chang, Yi Meng, Fink, Anna Maria, Tausch, Eugen, Schneider, Christof, Ritgen, Matthias, Kreuzer, Karl-Anton, Chyla, Brenda, Paulson, Joseph N., Pallasch, Christian P., Frenzel, Lukas P., Peifer, Martin, Eichhorst, Barbara, Stilgenbauer, Stephan, Jiang, Yanwen, Hallek, Michael, and Fischer, Kirsten

Published
2023
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24. Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

Author

Broséus, Julien, Hergalant, Sébastien, Vogt, Julia, Tausch, Eugen, Kreuz, Markus, Mottok, Anja, Schneider, Christof, Dartigeas, Caroline, Roos-Weil, Damien, Quinquenel, Anne, Moulin, Charline, Ott, German, Blanchet, Odile, Tomowiak, Cécile, Lazarian, Grégory, Rouyer, Pierre, Chteinberg, Emil, Bernhart, Stephan H., Tournilhac, Olivier, Gauchotte, Guillaume, Lomazzi, Sandra, Chapiro, Elise, Nguyen-Khac, Florence, Chery, Céline, Davi, Frédéric, Hunault, Mathilde, Houlgatte, Rémi, Rosenwald, Andreas, Delmer, Alain, Meyre, David, Béné, Marie-Christine, Thieblemont, Catherine, Lichter, Peter, Ammerpohl, Ole, Guéant, Jean-Louis, Guièze, Romain, Martin-Subero, José Ignacio, Cymbalista, Florence, Feugier, Pierre, Siebert, Reiner, and Stilgenbauer, Stephan

Published
2023
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25. Six-year follow-up and subgroup analyses of a phase 2 trial of venetoclax for del(17p) chronic lymphocytic leukemia

Author

Stilgenbauer, Stephan, Tausch, Eugen, Roberts, Andrew W., Davids, Matthew S., Eichhorst, Barbara, Hallek, Michael, Hillmen, Peter, Schneider, Christof, Schetelig, Johannes, Böttcher, Sebastian, Kater, Arnon P., Jiang, Yanwen, Boyer, Michelle, Popovic, Relja, Ghanim, Majd T., Moran, Michael, Sinai, Wendy J., Wang, Xifeng, Mukherjee, Nabanita, Chyla, Brenda, Wierda, William G., and Seymour, John F.

Published
2024
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26. Venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: 6-year results of the randomized phase 3 CLL14 study

Author

Al-Sawaf, Othman, Robrecht, Sandra, Zhang, Can, Olivieri, Stefano, Chang, Yi Meng, Fink, Anna Maria, Tausch, Eugen, Schneider, Christof, Ritgen, Matthias, Kreuzer, Karl-Anton, Sivchev, Liliya, Niemann, Carsten Utoft, Schwarer, Anthony, Loscertales, Javier, Weinkove, Robert, Strumberg, Dirk, Kilfoyle, Allanah, Manzoor, Beenish S., Jawaid, Dureshahwar, Emechebe, Nnadozie, Devine, Jacob, Boyer, Michelle, Runkel, Eva D., Eichhorst, Barbara, Stilgenbauer, Stephan, Jiang, Yanwen, Hallek, Michael, and Fischer, Kirsten

Published
2024
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28. Strain-engineering of the charge and spin-orbital interactions in Sr2IrO4

Author

Paris, Eugenio, Tseng, Yi, Pärschke, Ekaterina M., Zhang, Wenliang, Upton, Mary H., Efimenko, Anna, Rolfs, Katharina, McNally, Daniel E., Maurel, Laura, Naamneh, Muntaser, Caputo, Marco, Strocov, Vladimir N., Wang, Zhiming, Casa, Diego, Schneider, Christof W., Pomjakushina, Ekaterina, Wohlfeld, Krzysztof, Radovic, Milan, and Schmitt, Thorsten

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

In the high spin-orbit coupled Sr2IrO4, the high sensitivity of the ground state to the details of the local lattice structure shows a large potential for the manipulation of the functional properties by inducing local lattice distortions. We use epitaxial strain to modify the Ir-O bond geometry in Sr2IrO4 and perform momentum-dependent Resonant Inelastic X-ray Scattering (RIXS) at the metal and at the ligand sites to unveil the response of the low energy elementary excitations. We observe that the pseudospin-wave dispersion for tensile-strained Sr2IrO4 films displays large softening along the [h,0] direction, while along the [h,h] direction it shows hardening. This evolution reveals a renormalization of the magnetic interactions caused by a strain-driven crossover from anisotropic to isotropic interactions between the magnetic moments. Moreover, we detect dispersive electron-hole pair excitations which shift to lower (higher) energies upon compressive (tensile) strain, manifesting a reduction (increase) in the size of the charge gap. This behavior shows an intimate coupling between charge excitations and lattice distortions in Sr2IrO4, originating from the modified hopping elements between the t2g orbitals. Our work highlights the central role played by the lattice degrees of freedom in determining both the pseudospin and charge excitations of Sr2IrO4 and provides valuable information towards the control of the ground state of complex oxides in the presence of high spin-orbit coupling., Comment: Published in Proceedings of the National Academy of Sciences, September 2020

Published
2020
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29. Proximity-Induced Odd-Frequency Superconductivity in a Topological Insulator

Author

Krieger, Jonas A., Pertsova, Anna, Giblin, Sean R., Döbeli, Max, Prokscha, Thomas, Schneider, Christof W., Suter, Andreas, Hesjedal, Thorsten, Balatsky, Alexander V., and Salman, Zaher

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

At an interface between a topological insulator (TI) and a conventional superconductor (SC), superconductivity has been predicted to change dramatically and exhibit novel correlations. In particular, the induced superconductivity by an $s$-wave SC in a TI can develop an order parameter with a $p$-wave component. Here we present experimental evidence for an unexpected proximity-induced novel superconducting state in a thin layer of the prototypical TI, Bi$_2$Se$_3$, proximity coupled to Nb. From depth-resolved magnetic field measurements below the superconducting transition temperature of Nb, we observe a local enhancement of the magnetic field in Bi$_2$Se$_3$ that exceeds the externally applied field, thus supporting the existence of an intrinsic paramagnetic Meissner effect arising from an odd-frequency superconducting state. Our experimental results are complemented by theoretical calculations supporting the appearance of such a component at the interface which extends into the TI. This state is topologically distinct from the conventional Bardeen-Cooper-Schrieffer state it originates from. To the best of our knowledge, these findings present a first observation of bulk odd-frequency superconductivity in a TI. We thus reaffirm the potential of the TI-SC interface as a versatile platform to produce novel superconducting states., Comment: Accepted version for publication in Physical Review Letters

Published
2020
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31. Final analysis of the CLL2-GIVe trial: obinutuzumab, ibrutinib, and venetoclax for untreated CLL with del(17p)/TP53mut

Author

Huber, Henriette, Tausch, Eugen, Schneider, Christof, Edenhofer, Simone, von Tresckow, Julia, Robrecht, Sandra, Giza, Adam, Zhang, Can, Fürstenau, Moritz, Dreger, Peter, Ritgen, Matthias, Illmer, Thomas, Illert, Anna Lena, Dürig, Jan, Böttcher, Sebastian, Niemann, Carsten U., Kneba, Michael, Al-Sawaf, Othman, Kreuzer, Karl-Anton, Fink, Anna-Maria, Fischer, Kirsten, Döhner, Hartmut, Hallek, Michael, Eichhorst, Barbara, and Stilgenbauer, Stephan

Published
2023
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32. High karyotypic complexity is an independent prognostic factor in patients with CLL treated with venetoclax combinations

Author

Fürstenau, Moritz, Thus, Yvonne J., Robrecht, Sandra, Mellink, Clemens H. M., van der Kevie-Kersemaekers, Anne-Marie, Dubois, Julie, von Tresckow, Julia, Patz, Michaela, Gregor, Michael, Thornton, Patrick, Staber, Philipp B., Tadmor, Tamar, Levin, Mark-David, da Cunha-Bang, Caspar, Schneider, Christof, Poulsen, Christian Bjoern, Illmer, Thomas, Schöttker, Björn, Janssens, Ann, Christiansen, Ilse, Nösslinger, Thomas, Baumann, Michael, Hebart, Holger, Gaska, Tobias, Regelink, Josien C., Dompeling, Ellen C., Lindström, Vesa, Juliusson, Gunnar, Widmer, Anouk, Goede, Jeroen, Goldschmidt, Neta, Simon, Florian, De Silva, Nisha, Fink, Anna-Maria, Fischer, Kirsten, Wendtner, Clemens-Martin, Ritgen, Matthias, Brüggemann, Monika, Tausch, Eugen, Spaargaren, Marcel, Eldering, Eric, Stilgenbauer, Stephan, Niemann, Carsten U., Hallek, Michael, Eichhorst, Barbara, Kreuzer, Karl-Anton, and Kater, Arnon P.

Published
2023
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33. Electronic Localization in CaVO3 Films via Bandwidth Control

Author

McNally, Daniel E., Lu, Xingye, Pelliciari, Jonathan, Beck, Sophie, Dantz, Marcus, Naamneh, Muntaser, Shang, Tian, Medarde, Marisa, Schneider, Christof W., Strocov, Vladimir N., Pomjakushina, Ekaterina V., Ederer, Claude, Radovic, Milan, and Schmitt, Thorsten

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Understanding and controlling the electronic structure of thin layers of quantum materials is a crucial first step towards designing heterostructures where new phases and phenomena, including the metal-insulator transition (MIT), emerge. Here, we demonstrate control of the MIT via tuning electronic bandwidth and local site environment through selection of the number of atomic layers deposited. We take CaVO3, a correlated metal in its bulk form that has only a single electron in its V4+ 3d manifold, as a representative example. We find that thick films and ultrathin films (6 unit cells, uc, and below) are metallic and insulating, respectively, while a 10 uc CaVO3 film exhibits a clear thermal MIT. Our combined X-ray absorption spectroscopy and resonant inelastic x-ray scattering (RIXS) study reveals that the thickness-induced MIT is triggered by electronic bandwidth reduction and local moment formation from V3+ ions, that are both a consequence of the thickness confinement. The thermal MIT in our 10 uc CaVO3 film exhibits similar changes in the RIXS response to that of the thickness-induced MIT in terms of reduction of bandwidth and V 3d - O 2p hybridization., Comment: 27 pages, 6 figures

Published
2019
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35. Relationship between crystal structure and multiferroic orders in orthorhombic perovskite manganites

Author

Fedorova, Natalya S., Windsor, Yoav William, Findler, Christoph, Ramakrishnan, Mahesh, Bortis, Amadé, Rettig, Laurenz, Shimamoto, Kenta, Bothschafter, Elisabeth M., Porer, Michael, Esposito, Vincent, Hu, Yi, Alberca, Aurora, Lippert, Thomas, Schneider, Christof W., Staub, Urs, and Spaldin, Nicola A.

Subjects
Condensed Matter - Materials Science
Abstract

We use resonant and non-resonant X-ray diffraction measurements in combination with first-principles electronic structure calculations and Monte Carlo simulations to study the relationship between crystal structure and multiferroic orders in the orthorhombic perovskite manganites, o-$R$MnO$_3$ ($R$ is a rare-earth cation or Y). In particular, we focus on how the internal lattice parameters (Mn-O bond lengths and Mn-O-Mn bond angles) evolve under chemical pressure and epitaxial strain, and the effect of these structural variations on the microscopic exchange interactions and long-range magnetic order. We show that chemical pressure and epitaxial strain are accommodated differently by the crystal lattice of o-$R$MnO$_3$, which is key for understanding the difference in magnetic properties between bulk samples and strained films. Finally, we discuss the effects of these differences in the magnetism on the electric polarization in o-$R$MnO$_3$., Comment: 16 pages, 10 figures

Published
2018
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36. Obinutuzumab, acalabrutinib, and venetoclax, after an optional debulking with bendamustine in relapsed or refractory chronic lymphocytic leukaemia (CLL2-BAAG): a multicentre, open-label, phase 2 trial

Author

Cramer, Paula, Fürstenau, Moritz, Robrecht, Sandra, Giza, Adam, Zhang, Can, Fink, Anna-Maria, Fischer, Kirsten, Langerbeins, Petra, Al-Sawaf, Othman, Tausch, Eugen, Schneider, Christof, Schetelig, Johannes, Dreger, Peter, Böttcher, Sebastian, Kreuzer, Karl-Anton, Schilhabel, Anke, Ritgen, Matthias, Brüggemann, Monika, Kneba, Michael, Stilgenbauer, Stephan, Eichhorst, Barbara, and Hallek, Michael

Published
2022
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37. Obinutuzumab (GA-101), ibrutinib, and venetoclax (GIVe) frontline treatment for high-risk chronic lymphocytic leukemia

Author

Huber, Henriette, Edenhofer, Simone, von Tresckow, Julia, Robrecht, Sandra, Zhang, Can, Tausch, Eugen, Schneider, Christof, Bloehdorn, Johannes, Fürstenau, Moritz, Dreger, Peter, Ritgen, Matthias, Illmer, Thomas, Illert, Anna L., Dürig, Jan, Böttcher, Sebastian, Niemann, Carsten U., Kneba, Michael, Fink, Anna-Maria, Fischer, Kirsten, Döhner, Hartmut, Hallek, Michael, Eichhorst, Barbara, and Stilgenbauer, Stephan

Published
2022
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38. Single-axis dependent structural and multiferroic properties of orthorhombic RMnO$_3$ (R = Gd - Lu)

Author

Shimamoto, Kenta, Mukherjee, Saumya, Bingham, Nicholas S., Suszka, Anna K., Lippert, Thomas, Niedermayer, Christof, and Schneider, Christof W.

Subjects
Condensed Matter - Materials Science
Abstract

Controlling material properties by modulating the crystalline structure has been attempted using various techniques, e.g., hydrostatic pressure, chemical pressure, and epitaxy. These techniques succeed to improve properties and achieve desired functionalities by changing the unit cell in all dimensions. In order to obtain a more detailed understanding on the relation between the crystal lattice and material properties, it is desirable to investigate the influence of a smaller number of parameters. Here, we utilize the combination of chemical pressure and epitaxy to modify a single lattice parameter of the multiferroic orthorhombic RMnO$_3$ (R = rare-earth, o-RMnO$_3$) system. By growing a series of o-RMnO$_3$ (R = Gd - Lu) films coherently on (010)-oriented YAlO$_3$ substrates, the influence of chemical pressure is reflected only along the $b$-axis. Thus, a series of o-RMnO$_3$ with $a$ ~ 5.18 {\AA}, 5.77 {\AA} < $b$ < 5.98 {\AA}, and $c$ ~ 7.37 {\AA} were obtained. Raman spectra analysis reveals that the change of the $b$-axis parameter induces a shift of the oxygen in the nominally "fixed" $ca$-plane. Their ferroelectric ground state is independent on the $b$-axis parameter showing polarization of ~ 1 $\mu$C cm$^{-2}$ along the $a$-axis for the above-mentioned range, except for $b$ ~ 5.94 {\AA} which corresponds to TbMnO$_3$ showing ~ 2 $\mu$C cm$^{-2}$. This result implies that multiferroic order of o-RMnO$_3$ is almost robust against the $b$-axis parameter provided that the dimension of the $ca$-plane is fixed to 7.37 {\AA} $\times$ 5.18 {\AA}.

Published
2017
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39. Infections in patients with chronic lymphocytic leukemia treated with time limited targeted drug combinations.

Author

Langerbeins, Petra, Giza, Adam, Robrecht, Sandra, Cramer, Paula, von Tresckow, Julia, Al‐Sawaf, Othman, Fink, Anna Maria, Fürstenau, Moritz, Kater, Arnon P., van der Spek, Ellen, Niemann, Carsten Utoft, da Cunha‐Bang, Caspar, Tausch, Eugen, Schneider, Christof, Stilgenbauer, Stephan, Fischer, Kirsten, Hallek, Michael, and Eichhorst, Barbara

Published
2024
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40. Fludarabine, cyclophosphamide, and rituximab as first‐line treatment in patients with chronic lymphocytic leukemia: A long‐term analysis of the German CLL Study Group (GCLLSG) registry.

Author

Kutsch, Nadine, Giza, Adam, Robrecht, Sandra, Stumpf, Janina, Federhen, Anno, Stoltefuß, Andrea, Vehling‐Kaiser, Ursula, Koenigsmann, Michael, Tausch, Eugen, Schneider, Christof, Stilgenbauer, Stephan, Illmer, Thomas, Schlag, Rudolf, Dörfel, Steffen, Gaska, Tobias, Kiehl, Michael, Müller‐Hagen, Sigrun, Moorahrend, Enno, Linde, Hartmut, and Schlenska‐Lange, Anke

Subjects
CHRONIC lymphocytic leukemia, CYCLOPHOSPHAMIDE, FLUDARABINE, RITUXIMAB, OVERALL survival
Abstract

Long‐term data of chronic lymphocytic leukemia (CLL) patients with favorable risk who were treated with fludarabine, cyclophosphamide, and rituximab (FCR) within clinical trials show good efficacy. We here report long‐term data collected within the GCLLSG registry. Altogether, 417 CLL patients who received first‐line treatment with FCR were analyzed, of which 293 (70.3%) were treated outside of clinical trials. The median observation time from first‐line was 95.8 (interquartile range 58.7–126.8) months. Focusing on data of 194 (46.5%) patients who received FCR first‐line treatment after 2013 (start of data collection within GCLLSG registry), responses were documented in 85% of the patients, non‐responses in 15%, and for 3.6% the assessment was missing. Median event‐free survival (EFS, time until disease progression, subsequent treatment, or death) was 60.2 months with a 5‐year EFS‐rate of 50.6%. Patients with higher‐risk disease, characterized by unmutated IGHV (N = 78), had a median EFS of 45.4 months with a 5‐year EFS rate of 36.3%, while the median EFS was 77.5 months with a 5‐year EFS rate of 60.3% in patients with mutated IGHV (N = 40). Median overall survival was not reached with a 5‐year survival rate of 92.7%. In summary, first‐line FCR was associated with long EFS, especially in patients exhibiting a mutated IGHV status. [ABSTRACT FROM AUTHOR]

Published
2024
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43. IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

Author

Maity, Palash C., Bilal, Mayas, Koning, Marvyn T., Young, Marc, van Bergen, Cornelis A. M., Renna, Valerio, Nicolò, Antonella, Datta, Moumita, Gentner-Göbel, Eva, Barendse, Rob S., Somers, Sebastiaan F., de Groen, Ruben A. L., Vermaat, Joost S. P., Steinbrecher, Daniela, Schneider, Christof, Tausch, Eugen, Bittolo, Tamara, Bomben, Riccardo, Mazzarello, Andrea Nicola, del Poeta, Giovanni, Kroes, Wilma G. M., van Wezel, J. Tom, Imkeller, Katharina, Busse, Christian E., Degano, Massimo, Bakchoul, Tamam, Schulz, Axel Ronald, Mei, Henrik, Ghia, Paolo, Kotta, Konstantia, Stamatopoulos, Kostas, Wardemann, Hedda, Zucchetto, Antonella, Chiorazzi, Nicholas, Gattei, Valter, Stilgenbauer, Stephan, Veelken, Hendrik, and Jumaa, Hassan

Published
2020

44. Tuning the multiferroic mechanisms of TbMnO3 by epitaxial strain

Author

Shimamoto, Kenta, Mukherjee, Saumya, Manz, Sebastian, White, Jonathan S., Trassin, Morgan, Kenzelmann, Michel, Chapon, Laurent, Lippert, Thomas, Fiebig, Manfred, Schneider, Christof W., and Niedermayer, Christof

Subjects
Condensed Matter - Materials Science
Abstract

A current challenge in the field of magnetoelectric multiferroics is to identify systems that allow a controlled tuning of states displaying distinct magnetoelectric responses. Here we show that the multiferroic ground state of the archetypal multiferroic TbMnO3 is dramatically modified by epitaxial strain. Neutron diffraction reveals that in highly strained films the magnetic order changes from the bulk-like incommensurate bc-cycloidal structure to commensurate magnetic order. Concomitant with the modification of the magnetic ground state, optical second-harmonic generation (SHG) and electric measurements show an enormous increase of the ferroelectric polarization, and a change in its direction from along the c- to the a-axis. Our results suggest that the drastic change of multiferroic properties results from a switch of the spin-current magnetoelectric coupling in bulk TbMnO3 to symmetric magnetostriction in epitaxially-strained TbMnO3. These findings experimentally demonstrate that epitaxial strain can be used to control single-phase spin-driven multiferroic states.

Published
2016
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45. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

Author

Agathangelidis, Andreas, Chatzidimitriou, Anastasia, Gemenetzi, Katerina, Giudicelli, Veronique, Karypidou, Maria, Plevova, Karla, Davis, Zadie, Yan, Xiao-Jie, Jeromin, Sabine, Schneider, Christof, Pedersen, Lone Bredo, Tschumper, Renee C., Sutton, Lesley-Ann, Baliakas, Panagiotis, Scarfò, Lydia, van Gastel, Ellen J., Armand, Marine, Tausch, Eugen, Biderman, Bella, Baer, Constance, Bagnara, Davide, Navarro, Alba, Langlois de Septenville, Anne, Guido, Valentina, Mitterbauer-Hohendanner, Gerlinde, Dimovski, Aleksandar, Brieghel, Christian, Lawless, Sarah, Meggendorfer, Manja, Brazdilova, Kamila, Ritgen, Matthias, Facco, Monica, Tresoldi, Cristina, Visentin, Andrea, Patriarca, Andrea, Catherwood, Mark, Bonello, Lisa, Sudarikov, Andrey, Vanura, Katrina, Roumelioti, Maria, Skuhrova Francova, Hana, Moysiadis, Theodoros, Veronese, Silvio, Giannopoulos, Krzysztof, Mansouri, Larry, Karan-Djurasevic, Teodora, Sandaltzopoulos, Raphael, Bödör, Csaba, Fais, Franco, Kater, Arnon, Panovska, Irina, Rossi, Davide, Alshemmari, Salem, Panagiotidis, Panagiotis, Costeas, Paul, Espinet, Blanca, Antic, Darko, Foroni, Letizia, Montillo, Marco, Trentin, Livio, Stavroyianni, Niki, Gaidano, Gianluca, Francia di Celle, Paola, Niemann, Carsten, Campo, Elias, Anagnostopoulos, Achilles, Pott, Christiane, Fischer, Kirsten, Hallek, Michael, Oscier, David, Stilgenbauer, Stephan, Haferlach, Claudia, Jelinek, Diane, Chiorazzi, Nicholas, Pospisilova, Sarka, Lefranc, Marie-Paule, Kossida, Sofia, Langerak, Anton W., Belessi, Chrysoula, Davi, Frederic, Rosenquist, Richard, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2021
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46. Electron-phonon Coupling and the Superconducting Phase Diagram of the LaAlO3-SrTiO3 Interface

Author

Boschker, Hans, Richter, Christoph, Fillis-Tsirakis, Evangelos, Schneider, Christof W., and Mannhart, Jochen

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

The superconductor at the LaAlO3-SrTiO3 interface provides a model system for the study of two-dimensional superconductivity in the dilute carrier density limit. Here we experimentally address the pairing mechanism in this superconductor. We extract the electron-phonon spectral function from tunneling spectra and conclude, without ruling out contributions of further pairing channels, that electron-phonon mediated pairing is strong enough to account for the superconducting critical temperatures. Furthermore, we discuss the electron-phonon coupling in relation to the superconducting phase diagram. The electron-phonon spectral function is independent of the carrier density, except for a small part of the phase diagram in the underdoped region. The tunneling measurements reveal that the increase of the chemical potential with increasing carrier density levels off and is zero in the overdoped region of the phase diagram. This indicates that the additionally induced carriers do not populate the band that hosts the superconducting state and that the superconducting order parameter therefore is weakened by the presence of charge carriers in another band.

Published
2015
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47. Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial

Author

Al-Sawaf, Othman, primary, Ligtvoet, Rudy, additional, Robrecht, Sandra, additional, Stumpf, Janina, additional, Fink, Anna-Maria, additional, Tausch, Eugen, additional, Schneider, Christof, additional, Boettcher, Sebastian, additional, Mikusko, Martin, additional, Ritgen, Matthias, additional, Schetelig, Johannes, additional, von Tresckow, Julia, additional, Vehling-Kaiser, Ursula, additional, Gaska, Tobias, additional, Wendtner, Clemens Martin, additional, Chapuy, Bjoern, additional, Fischer, Kirsten, additional, Kreuzer, Karl-Anton, additional, Stilgenbauer, Stephan, additional, Staber, Philipp, additional, Niemann, Carsten, additional, Hallek, Michael, additional, and Eichhorst, Barbara, additional

Published
2023
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49. Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia

Author

Bloehdorn, Johannes, Braun, Andrejs, Taylor-Weiner, Amaro, Jebaraj, Billy Michael Chelliah, Robrecht, Sandra, Krzykalla, Julia, Pan, Heng, Giza, Adam, Akylzhanova, Gulnara, Holzmann, Karlheinz, Scheffold, Annika, Johnston, Harvey E., Yeh, Ru-Fang, Klymenko, Tetyana, Tausch, Eugen, Eichhorst, Barbara, Bullinger, Lars, Fischer, Kirsten, Weisser, Martin, Robak, Tadeusz, Schneider, Christof, Gribben, John, Dahal, Lekh N., Carter, Mathew J., Elemento, Olivier, Landau, Dan A., Neuberg, Donna S., Cragg, Mark S., Benner, Axel, Hallek, Michael, Wu, Catherine J., Döhner, Hartmut, Stilgenbauer, Stephan, and Mertens, Daniel

Published
2021
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50. IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia

Author

Scheffold, Annika, Jebaraj, Billy Michael Chelliah, Tausch, Eugen, Bloehdorn, Johannes, Ghia, Paolo, Yahiaoui, Anella, Dolnik, Anna, Blätte, Tamara Jacqueline, Bullinger, Lars, Dheenadayalan, Rashmi Priyadharshini, Li, Li, Schneider, Christof, Chen, Shih-Shih, Chiorazzi, Nicholas, Dietrich, Sascha, Seiffert, Martina, Tannheimer, Stacey, Döhner, Hartmut, Mertens, Daniel, and Stilgenbauer, Stephan

Published
2019
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