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527 results on '"Schneider, Gerd-Helge"'

10. Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

Author

Binns, Thomas S., primary, Köhler, Richard M., additional, Vanhoecke, Jonathan, additional, Chikermane, Meera, additional, Gerster, Moritz, additional, Merk, Timon, additional, Pellegrini, Franziska, additional, Busch, Johannes L., additional, Habets, Jeroen G.V., additional, Cavallo, Allesia, additional, Li, Ningfei, additional, Horn, Andreas, additional, Krause, Patricia, additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Haufe, Stefan, additional, Kühn, Andrea A., additional, and Neumann, Wolf-Julian, additional

Published
2024
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15. The sensitivity of ECG contamination to surgical implantation site in brain computer interfaces

Author

Wolf-Julian Neumann, Majid Memarian Sorkhabi, Moaad Benjaber, Lucia K. Feldmann, Assel Saryyeva, Joachim K. Krauss, Maria Fiorella Contarino, Tomas Sieger, Robert Jech, Gerd Tinkhauser, Claudio Pollo, Chiara Palmisano, Ioannis U. Isaias, Daniel D. Cummins, Simon J. Little, Philip A. Starr, Vasileios Kokkinos, Schneider Gerd-Helge, Todd Herrington, Peter Brown, R. Mark Richardson, Andrea A. Kühn, and Timothy Denison

Subjects
Deep brain stimulation, Brain computer interface, Oscillations, Artifacts, Neuromodulation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Background: Brain sensing devices are approved today for Parkinson's, essential tremor, and epilepsy therapies. Clinical decisions for implants are often influenced by the premise that patients will benefit from using sensing technology. However, artifacts, such as ECG contamination, can render such treatments unreliable. Therefore, clinicians need to understand how surgical decisions may affect artifact probability. Objectives: Investigate neural signal contamination with ECG activity in sensing enabled neurostimulation systems, and in particular clinical choices such as implant location that impact signal fidelity. Methods: Electric field modeling and empirical signals from 85 patients were used to investigate the relationship between implant location and ECG contamination. Results: The impact on neural recordings depends on the difference between ECG signal and noise floor of the electrophysiological recording. Empirically, we demonstrate that severe ECG contamination was more than 3.2x higher in left-sided subclavicular implants (48.3%), when compared to right-sided implants (15.3%). Cranial implants did not show ECG contamination. Conclusions: Given the relative frequency of corrupted neural signals, we conclude that implant location will impact the ability of brain sensing devices to be used for “closed-loop” algorithms. Clinical adjustments such as implant location can significantly affect signal integrity and need consideration.

Published
2021
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18. Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease

Author

Köhler, Richard M., primary, Binns, Thomas S., additional, Merk, Timon, additional, Zhu, Guanyu, additional, Yin, Zixiao, additional, Zhao, Baotian, additional, Chikermane, Meera, additional, Vanhoecke, Jonathan, additional, Busch, Johannes L., additional, Habets, Jeroen G.V., additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Cavallo, Alessia, additional, Haufe, Stefan, additional, Zhang, Jianguo, additional, Kühn, Andrea A., additional, Haynes, John-Dylan, additional, and Neumann, Wolf-Julian, additional

Published
2023
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24. Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants

Author

Merk, Timon, primary, Köhler, Richard, additional, Peterson, Victoria, additional, Lyra, Laura, additional, Vanhoecke, Jonathan, additional, Chikermane, Meera, additional, Binns, Thomas, additional, Li, Ningfei, additional, Walton, Ashley, additional, Bush, Alan, additional, Sisterson, Nathan, additional, Busch, Johannes, additional, Lofredi, Roxanne, additional, Habets, Jeroen, additional, Huebl, Julius, additional, Zhu, Guanyu, additional, Yin, Zixiao, additional, Zhao, Baotian, additional, Merkl, Angela, additional, Bajbouj, Malek, additional, Krause, Patricia, additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Horn, Andreas, additional, Zhang, Jianguo, additional, Kühn, Andrea, additional, Richardson, R. Mark, additional, and Neumann, Wolf-Julian, additional

Published
2023
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30. Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson’s Disease

Author

Astalosch, Melanie, Mousavi, Mahta, Ribeiro, Luísa Martins, Schneider, Gerd-Helge, Stuke, Heiner, Haufe, Stefan, Borchers, Friedrich, Spies, Claudia, von Hofen-Hohloch, Judith, Al-Fatly, Bassam, Ebersbach, Georg, Franke, Christiana, Kühn, Andrea A., and Kübler-Weller, Dorothee

Abstract

Postoperative delirium (POD) is a serious complication following deep brain stimulation (DBS) but only received little attention. Its main risk factors are higher age and preoperative cognitive deficits. These are also main risk factors for long-term cognitive decline after DBS in Parkinson’s disease (PD). To identify risk factors for POD severity after DBS surgery in PD. 57 patients underwent DBS (21 female; age 60.2±8.2; disease duration 10.5±5.9 years). Preoperatively, general, PD– and surgery-specific predictors were recorded. Montreal Cognitive Assessment and the neuropsychological test battery CANTAB ConnectTMwere used to test domain-specific cognition. Volumes of the cholinergic basal forebrain were calculated with voxel-based morphometry. POD severity was recorded with the delirium scales Confusion Assessment Method for Intensive Care Unit (CAM-ICU) and Nursing Delirium Scale (NU-DESC). Spearman correlations were calculated for univariate analysis of predictors and POD severity and linear regression with elastic net regularization and leave-one-out cross-validation was performed to fit a multivariable model. 21 patients (36.8%) showed mainly mild courses of POD following DBS. Correlation between predicted and true POD severity was significant (spearman rho = 0.365, p = 0.001). Influential predictors were age (p < 0.001), deficits in attention and motor speed (p = 0.002), visual learning (p = 0.036) as well as working memory (p < 0.001), Nucleus basalis of Meynert volumes (p = 0.003) and burst suppression (p = 0.005). General but also PD– and surgery-specific factors were predictive of POD severity. These findings underline the multifaceted etiology of POD after DBS in PD. Valid predictive models must therefore consider general, PD– and surgery-specific factors.

Published
2024
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31. Long-Term Follow-Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation

Author

Koy, Anne, Kühn, Andrea A, Schiller, Petra, Huebl, Julius, Schneider, Gerd-Helge, Eckenweiler, Matthias, Rensing-Zimmermann, Cornelia, Coenen, Volker Arnd, Krauss, Joachim K, Saryyeva, Assel, Hartmann, Hans, Lorenz, Delia, Volkmann, Jens, Matthies, Cordula, Schnitzler, Alfons, Vesper, Jan, Gharabaghi, Alireza, Weiss, Daniel, Bevot, Andrea, Marks, Warren, Howser, Angela, Monbaliu, Elegast, Mueller, Joerg, Prinz-Langenohl, Reinhild, Visser-Vandewalle, Veerle, Timmermann, Lars, and STIM-CP investigators

Subjects
dyskinetic cerebral palsy, children, prospective, trial, long-term effects, deep brain stimulation
Abstract

BACKGROUND: Deep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long-term effects and the safety profile are rare. OBJECTIVES: We assessed the efficacy and safety of pallidal DBS in pediatric patients with DCP. METHODS: The STIM-CP trial was a prospective, single-arm, multicenter study in which patients from the parental trial agreed to be followed-up for up to 36 months. Assessments included motor and non-motor domains. RESULTS: Of the 16 patients included initially, 14 (mean inclusion age 14 years) were assessed. There was a significant change in the (blinded) ratings of the total Dyskinesia Impairment Scale at 36 months. Twelve serious adverse events (possibly) related to treatment were documented. CONCLUSION: DBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. ispartof: Mov Disord ispartof: location:United States status: Published online

Published
2023

33. Surgical Site Infections Associated With Implanted Pulse Generators for Deep Brain Stimulation: Meta-Analysis and Systematic Review

Author

Spindler, Philipp, primary, Braun, Franziska, additional, Truckenmüller, Peter, additional, Wasilewski, David, additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Trampuz, Andrej, additional, Conen, Anna, additional, Kühn, Andrea A., additional, Vajkoczy, Peter, additional, and Prinz, Vincent, additional

Published
2023
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34. Christmas‐Related Reduction in Beta Activity in Parkinson's Disease

Author

Feldmann, Lucia K., primary, Lofredi, Roxanne, additional, Al‐Fatly, Bassam, additional, Busch, Johannes L., additional, Mathiopoulou, Varvara, additional, Roediger, Jan, additional, Krause, Patricia, additional, Schneider, Gerd‐Helge, additional, Faust, Katharina, additional, Horn, Andreas, additional, Kühn, Andrea A., additional, and Neumann, Wolf‐Julian, additional

Published
2023
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36. Single Threshold Adaptive Deep Brain Stimulation in Parkinson's Disease Depends on Parameter Selection, Movement State and Controllability of Subthalamic Beta Activity

Author

Busch, Johannes L., primary, Kaplan, Jonathan, additional, Habets, Jeroen G. V., additional, Feldmann, Lucia K., additional, Roediger, Jan, additional, Köhler, Richard M., additional, Merk, Timon, additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Bergman, Hagai, additional, Neumann, Wolf-Julian, additional, and Kühn, Andrea A., additional

Published
2023
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37. Parameter selection drives electrophysiological responses to adaptive deep brain stimulation in Parkinson’s disease

Author

Busch, Johannes Leon, primary, Kaplan, Jonathan, additional, Habets, Jeroen, additional, Feldmann, Lucia, additional, Roediger, Jan, additional, Köhler, Richard, additional, Merk, Timon, additional, Faust, Katharina, additional, Schneider, Gerd-Helge, additional, Neumann, Wolf-Julian, additional, and Kühn, Andrea, additional

Published
2023
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45. Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial

Author

Volkmann, Jens, Mueller, Joerg, Deuschl, Günther, Kühn, Andrea A, Krauss, Joachim K, Poewe, Werner, Timmermann, Lars, Falk, Daniela, Kupsch, Andreas, Kivi, Anatol, Schneider, Gerd-Helge, Schnitzler, Alfons, Südmeyer, Martin, Voges, Jürgen, Wolters, Alexander, Wittstock, Matthias, Müller, Jan-Uwe, Hering, Sascha, Eisner, Wilhelm, Vesper, Jan, Prokop, Thomas, Pinsker, Marcus, Schrader, Christoph, Kloss, Manja, Kiening, Karl, Boetzel, Kai, Mehrkens, Jan, Skogseid, Inger Marie, Ramm-Pettersen, Jon, Kemmler, Georg, Bhatia, Kailash P, Vitek, Jerrold L, and Benecke, Reiner

Published
2014
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48. Thoracolumbar Instrumentation Surgery in Patients with Parkinson's Disease: A Case-Control Study.

Author

Spindler, Philipp, Tkatschenko, Dimitri, Alzoobi, Yasmin, Kuebler, Dorothee, Kühn, Andrea A., Schneider, Gerd-Helge, Prinz, Vincent, Vajkoczy, Peter, and Faust, Katharina

Subjects
PARKINSON'S disease, CASE-control method, MUSCLE tone, GAIT disorders, BONE density
Abstract

Background With increasing prevalence of Parkinson's disease (PD), instrumentation surgery of the thoracolumbar spine of PD patients grows in importance. Poor operative results with high rates of revision surgery have been reported. The goal of this study was to compare the biomechanical complications of thoracolumbar instrumentation surgery of patients with and without PD. Methods In a retrospective case-control study, we compared 16 PD patients with a matched cohort of 104 control patients regarding the following postinstrumentation complications: (1) adjacent joint disease, (2) material failure, and (3) material loosening. Also, we compared the spinal bone density, which is the main prognostic criteria for failed instrumentation surgery, between the groups. Results We found the rate of material revision to be significantly higher in PD patients (43.8 vs. 13.5%, p = 0.008, odds ratio (OR) = 5.0). Furthermore, the indications for revision surgery differed between the groups, with more hardware failures in the PD group and more adjacent segment degeneration in the control group. PD patients profited from modern operation techniques (percutaneous instrumentation and CT-navigated screw implantation). Hospitalization was significantly longer for PD patients (20.2 ± 15.1 vs. 14.1 ± 8.9 days, p = 0.03). Conclusion PD patients exhibit challenging biomechanical demands on instrumenting the spine. Besides osteoporosis, especially sagittal imbalance, gait disturbance, and altered muscle tone may be contributive. PD patients may particularly profit from navigated and less invasive surgical techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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