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1. Echocardiographic assessment of right ventricular systolic function in conscious healthy dogs following a single dose of pimobendan versus atenolol

Author

Visser, Lance C, Scansen, Brian A, Brown, Nicole V, Schober, Karsten E, and Bonagura, John D

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Heart Disease, Cardiovascular, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Adrenergic beta-1 Receptor Antagonists, Animals, Atenolol, Cardiotonic Agents, Cross-Over Studies, Dogs, Pyridazines, Tricuspid Valve, Ultrasonography, Ventricular Function, Right, Canine, Cardiac, Echocardiography, Ultrasound, Veterinary sciences
Abstract

ObjectiveTo quantify drug-induced changes in right ventricular (RV) systolic function after administration of pimobendan and atenolol.Animals80 healthy privately-owned dogs.MethodsUsing a prospective, blinded, fully-crossed study design with randomized drug administration, RV systolic function was determined twice at two time periods; before and 3 h after administration of pimobendan (0.25 mg/kg PO) or atenolol (1 mg/kg PO). Indices of RV systolic function included tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), pulsed-wave tissue Doppler-derived systolic myocardial velocity of the lateral tricuspid annulus (S'), and speckle-tracking-derived global longitudinal RV free wall strain and strain rate. The effect of treatment on percent change from baseline RV function was analyzed with a linear mixed model including the covariates heart rate, body weight, age, gender, drug sequence, and time period.ResultsAll indices showed a significant (p

Published
2015

7. Trypanosoma cruzi infection diagnosed in dogs in nonendemic areas and results from a survey suggest a need for increased Chagas disease awareness in North America

Author

Gavic, Emily A., primary, Achen, Sarah E., additional, Fox, Phillip R., additional, Benjamin, Eduardo J., additional, Goodwin, Jonathan, additional, Gunasekaran, Tamilselvam, additional, Schober, Karsten E., additional, Tjostheim, Sonja S., additional, Vickers, John, additional, Ward, Jessica L., additional, Russell, Duncan S., additional, Rishniw, Mark, additional, Hamer, Sarah A., additional, and Saunders, Ashley B., additional

Published
2023
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15. Retrospective evaluation of hypertrophic cardiomyopathy in 68 dogs

Author

Schober, Karsten E; https://orcid.org/0000-0002-1286-0759, Fox, Phillip R; https://orcid.org/0000-0003-4089-0573, Abbott, Jonathan; https://orcid.org/0000-0001-6981-8968, Côté, Etienne, Luis-Fuentes, Virginia; https://orcid.org/0000-0001-8076-3806, Matos, Jose Novo; https://orcid.org/0000-0001-8128-8111, Stern, Joshua A, Visser, Lance; https://orcid.org/0000-0002-3563-0737, Scollan, Katherine F, Chetboul, Valerie; https://orcid.org/0000-0001-7891-1814, Schrope, Donald, Glaus, Tony M; https://orcid.org/0000-0003-2456-9536, Santilli, Roberto; https://orcid.org/0000-0001-5937-2050, Pariaut, Romain, Stepien, Rebecca, Arqued-Soubeyran, Vanessa, Toaldo, Marco Baron; https://orcid.org/0000-0001-9609-1856, Estrada, Amara, MacDonald, Kristin, Karlin, Emily T, Rush, John; https://orcid.org/0000-0002-8277-8996, Schober, Karsten E; https://orcid.org/0000-0002-1286-0759, Fox, Phillip R; https://orcid.org/0000-0003-4089-0573, Abbott, Jonathan; https://orcid.org/0000-0001-6981-8968, Côté, Etienne, Luis-Fuentes, Virginia; https://orcid.org/0000-0001-8076-3806, Matos, Jose Novo; https://orcid.org/0000-0001-8128-8111, Stern, Joshua A, Visser, Lance; https://orcid.org/0000-0002-3563-0737, Scollan, Katherine F, Chetboul, Valerie; https://orcid.org/0000-0001-7891-1814, Schrope, Donald, Glaus, Tony M; https://orcid.org/0000-0003-2456-9536, Santilli, Roberto; https://orcid.org/0000-0001-5937-2050, Pariaut, Romain, Stepien, Rebecca, Arqued-Soubeyran, Vanessa, Toaldo, Marco Baron; https://orcid.org/0000-0001-9609-1856, Estrada, Amara, MacDonald, Kristin, Karlin, Emily T, and Rush, John; https://orcid.org/0000-0002-8277-8996

Abstract

BACKGROUND: There is a lack of clinical data on hypertrophic cardiomyopathy (HCM) in dogs. HYPOTHESIS/OBJECTIVES: To investigate signalment, clinical signs, diagnostic findings, and survival in dogs with HCM. ANIMALS: Sixty-eight client-owned dogs. METHODS: Retrospective multicenter study. Medical records were searched between 2003 and 2015. The diagnosis of left ventricular (LV) hypertrophy was made by echocardiographic examination. RESULTS: Three hundred and forty-five dogs with LV hypertrophy were identified, of which 277 were excluded. The remaining 68 dogs were 0.3 to 14 years old and predominantly <10 kg (85%), and without a sex predilection. Twenty-four % were Shih Tzu and 24% terrier breeds. Most (80%) had a systolic heart murmur. Owner-determined exercise intolerance (37%) and syncope (18%) were most commonly reported signs. The majority (84%) of dogs had symmetrical LV hypertrophy, whereas asymmetrical septal and LV free wall hypertrophy was observed in 9% and 6% of dogs, respectively. Isolated basal interventricular septal hypertrophy was not observed. Commonly recorded were systolic anterior motion of the mitral valve (60%) and LV diastolic dysfunction (89% of dogs where diastolic function was evaluated). Six dogs died unexpectedly, and 3 developed congestive heart failure. Known survival times were between 1 day and 114 months after diagnosis. CONCLUSIONS AND CLINICAL IMPORTANCE: Hypertrophic cardiomyopathy in dogs should be considered as a differential diagnosis if LV hypertrophy is identified. Small breed dogs are overrepresented, and it is uncommon for dogs with HCM to develop CHF although sudden death can occur.

Published
2022

17. Retrospective evaluation of hypertrophic cardiomyopathy in 68 dogs

Author

Schober, Karsten E., primary, Fox, Phillip R., additional, Abbott, Jonathan, additional, Côté, Etienne, additional, Luis‐Fuentes, Virginia, additional, Matos, Jose Novo, additional, Stern, Joshua A., additional, Visser, Lance, additional, Scollan, Katherine F., additional, Chetboul, Valerie, additional, Schrope, Donald, additional, Glaus, Tony, additional, Santilli, Roberto, additional, Pariaut, Romain, additional, Stepien, Rebecca, additional, Arqued‐Soubeyran, Vanessa, additional, Toaldo, Marco Baron, additional, Estrada, Amara, additional, MacDonald, Kristin, additional, Karlin, Emily T., additional, and Rush, John, additional

Published
2022
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18. Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats

Author

Fox, Philip R., Oyama, Mark A., Reynolds, Caryn, Rush, John E., DeFrancesco, Terri C., Keene, Bruce W., Atkins, Clark E., MacDonald, Kristin A., Schober, Karsten E., Bonagura, John D., Stepien, Rebecca L., Kellihan, Heidi B., Nguyenba, Thaibinh P., Lehmkuhl, Linda B., Lefbom, Bonnie K., Moise, N. Sydney, and Hogan, Daniel F.

Published
2009
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21. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study

Author

Schober, Karsten E; https://orcid.org/0000-0002-1286-0759, Rush, John E; https://orcid.org/0000-0002-8277-8996, Luis Fuentes, Virginia; https://orcid.org/0000-0001-8076-3806, Glaus, Tony; https://orcid.org/0000-0003-2456-9536, Summerfield, Nuala J, Wright, Kathy; https://orcid.org/0000-0002-7927-3145, Lehmkuhl, Linda, Wess, Gerhard; https://orcid.org/0000-0002-6634-8072, Sayer, Margaret P, Loureiro, Joao, MacGregor, John, Mohren, Nicole, Schober, Karsten E; https://orcid.org/0000-0002-1286-0759, Rush, John E; https://orcid.org/0000-0002-8277-8996, Luis Fuentes, Virginia; https://orcid.org/0000-0001-8076-3806, Glaus, Tony; https://orcid.org/0000-0003-2456-9536, Summerfield, Nuala J, Wright, Kathy; https://orcid.org/0000-0002-7927-3145, Lehmkuhl, Linda, Wess, Gerhard; https://orcid.org/0000-0002-6634-8072, Sayer, Margaret P, Loureiro, Joao, MacGregor, John, and Mohren, Nicole

Abstract

Background: The benefits of pimobendan in the treatment of congestive heart failure (CHF) in cats with hypertrophic cardiomyopathy (HCM) have not been evaluated prospectively. Hypothesis/objectives: To investigate the effects of pimobendan in cats with HCM and recent CHF and to identify possible endpoints for a pivotal study. We hypothesized that pimobendan would be well-tolerated and associated with improved outcome. Animals: Eighty-three cats with HCM and recently controlled CHF: 30 with and 53 without left ventricular outflow tract obstruction. Methods: Prospective randomized placebo-controlled double-blind multicenter nonpivotal field study. Cats received either pimobendan (0.30 mg/kg q12h, n = 43), placebo (n = 39), or no medication (n = 1) together with furosemide (<10 mg/kg/d) with or without clopidogrel. The primary endpoint was a successful outcome (ie, completing the 180-day study period without a dose escalation of furosemide). Results: The proportion of cats in the full analysis set population with a successful outcome was not different between treatment groups (P = .75). For nonobstructive cats, the success rate was 32% in pimobendan-treated cats versus 18.2% in the placebo group (odds ratio [OR], 2.12; 95% confidence interval [CI], 0.54-8.34). For obstructive cats, the success rate was 28.6% and 60% in the pimobendan and placebo groups, respectively (OR, 0.27; 95% CI, 0.06-1.26). No difference was found between treatments for the secondary endpoints of time to furosemide dose escalation or death (P = .89). Results were similar in the per-protocol sets. Adverse events in both treatment groups were similar. Conclusions and clinical importance: In this study of cats with HCM and recent CHF, no benefit of pimobendan on 180-day outcome was identified.

Published
2021

22. Effects of pimobendan in cats with hypertrophic cardiomyopathy and recent congestive heart failure: Results of a prospective, double‐blind, randomized, nonpivotal, exploratory field study

Author

Schober, Karsten E., primary, Rush, John E., additional, Luis Fuentes, Virginia, additional, Glaus, Tony, additional, Summerfield, Nuala J., additional, Wright, Kathy, additional, Lehmkuhl, Linda, additional, Wess, Gerhard, additional, Sayer, Margaret P., additional, Loureiro, Joao, additional, MacGregor, John, additional, and Mohren, Nicole, additional

Published
2021
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28. Contributors

Author

Anderson, Nancy L., primary, Alvarez, Francisco J., additional, Armbrust, Laura J., additional, Aron, Dennis N., additional, Bateman, Shane W., additional, Beale, Karin Muth, additional, Bednarski, Richard M., additional, Bellah, Jamie R., additional, Berkwitt, Larry, additional, Bettenay, Sonya V., additional, Biller, David S., additional, Birchard, Stephen J., additional, Bjorling, Dale E., additional, Bohling, Mark W., additional, Bonagura, John D., additional, Bonczynski, Jennifer, additional, Boothe, Harry W., additional, Boudrieau, Randy J., additional, Bowles, Heather L., additional, Bright, Ronald M., additional, Brooks, Marjory B., additional, Budsberg, Steven C., additional, Buffington, C. Anthony, additional, Calvert, Clay A., additional, Carothers, Marcia A., additional, Chen, Sue, additional, Chew, Dennis J., additional, Cole, Lynette K., additional, Colitz, Carmen M.H., additional, Osborn, Sarah Colombini, additional, Cuddon, Paul A., additional, Costa-Gómez, Támara M., additional, Davis, Kechia M., additional, DeCamp, Charles E., additional, Dueland, R. Tass, additional, Dziezyc, Joan, additional, Egger, Erick L., additional, Ellis, Christine, additional, Fenner, William R., additional, Fingland, Roger B., additional, Ford, Richard B., additional, Forrester, S. Dru, additional, Frank, Linda A., additional, Gamblin, Rance M., additional, Gieg, Jennifer, additional, Gilson, Stephen D., additional, Glaze, Mary B., additional, Graham, Joanne C., additional, Grant, David, additional, Graves, Thomas K., additional, Greco, Deborah S., additional, Green, Henry W., additional, Greenberg, Tia B., additional, Griffin, Craig E., additional, Grooters, Amy M., additional, Hamlin, Robert L., additional, Harris, Don J., additional, Hay, Callum W., additional, Hedlund, Cheryl S., additional, Helton-Rhodes, Karen, additional, Hillier, Andrew, additional, Holloway, Cheryl, additional, Hitchinson, Robert V., additional, Hubbell, John A.E., additional, Jerram, Richard M., additional, Johnson, Lynelle R., additional, Johnson, Susan E., additional, Johnston, Matthew S., additional, Jones, Denise, additional, Kay, Nancy D., additional, Keene, Bruce W., additional, Kern, Thomas J., additional, Kintzer, Peter P., additional, Kirschner, Susan E., additional, Kisseberth, William C., additional, Knapp, David W., additional, Koplitz, Shianne L., additional, Kowaleski, Michael P., additional, Kunkle, Gail A., additional, Kwochka, Kenneth W., additional, Labato, Mary Anna, additional, Lehmkuhl, Linda B., additional, Luttgen, Patricia J., additional, Manley, Paul A., additional, March, Philip A., additional, Marretta, Sandra Manfra, additional, Matthews, Hilary K., additional, McEntee, Margaret C., additional, McLoughlin, Mary A., additional, Miller, Michael S., additional, Millichamp, Nicholas J., additional, Millis, Darryl L., additional, Milovancev, Milan, additional, Moore, Cecil P., additional, Morris, Daniel O., additional, Mueller, Ralf S., additional, Muir, William W., additional, Mundell, Alan C., additional, Nichols, Rhett, additional, Noxon, James O., additional, Oglesbee, Barbara L., additional, Olmstead, Marvin L., additional, Page, Rodney L., additional, Palmisano, Matthew, additional, Panciera, David L., additional, Parker, Robert B., additional, Peterson, Janet L., additional, Peterson, Mark E., additional, Pilny, Anthony, additional, Pinchbeck, Lauren R., additional, Podell, Michael, additional, Prueter, James C., additional, Quesenberry, Katherine E., additional, Randolph, John F., additional, Raskin, Rose E., additional, Reine, Nyssa J., additional, Ridge, Laura G., additional, Rochat, Mark C., additional, Rosenkrantz, Wayne S., additional, Rosser, Edmund J., additional, Roush, James K., additional, Rush, John E., additional, Samii, Valerie F., additional, Scagliotti, Randall H., additional, Scheidt, Vicki J., additional, Schenck, Patricia A., additional, Schertel, Eric R., additional, Schober, Karsten E., additional, Shell, Linda G., additional, Shelton, G. Diane, additional, Sherding, Robert G., additional, Shires, Peter, additional, Sicard, Gretchen K., additional, Smeak, Daniel D., additional, Smith, Francis W.K., additional, Smith, Mark M., additional, Stepien, Rebecca L., additional, Stone, Elizabeth A., additional, Stone, Michael, additional, Swaim, Steven F., additional, Taylor, Robert A., additional, Tilley, Larry P., additional, Tomlinson, James, additional, Vail, David M., additional, Wack, Raymund F., additional, White, Stephen D., additional, and Wilkie, David A., additional

Published
2006
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30. JOR959607_video_captions_for_supplementary_material – Supplemental material for Acquired left-to-right shunting through a valve-incompetent foramen ovale in a cat with hypertrophic cardiomyopathy and congestive heart failure

Author

Winter, Randolph L, Jennings, Ryan N, Cronin, James P, Rhinehart, Jaylyn D, and Schober, Karsten E

Subjects
70706 Veterinary Medicine, FOS: Veterinary sciences
Abstract

Supplemental material, JOR959607_video_captions_for_supplementary_material for Acquired left-to-right shunting through a valve-incompetent foramen ovale in a cat with hypertrophic cardiomyopathy and congestive heart failure by Randolph L Winter, Ryan N Jennings, James P Cronin, Jaylyn D Rhinehart and Karsten E Schober in Journal of Feline Medicine and Surgery Open Reports

Published
2020
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31. Long‐term incidence and risk of noncardiovascular and all‐cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Author

Fox, Philip R., primary, Keene, Bruce W., additional, Lamb, Kenneth, additional, Schober, Karsten E., additional, Chetboul, Valérie, additional, Luis Fuentes, Virginia, additional, Payne, Jessie Rose, additional, Wess, Gerhard, additional, Hogan, Daniel F., additional, Abbott, Jonathan A., additional, Häggström, Jens, additional, Culshaw, Geoffrey, additional, Fine‐Ferreira, Deborah, additional, Cote, Etienne, additional, Trehiou‐Sechi, Emilie, additional, Motsinger‐Reif, Alison A., additional, Nakamura, Reid K., additional, Singh, Manreet, additional, Ware, Wendy A., additional, Riesen, Sabine C., additional, Borgarelli, Michele, additional, Rush, John E., additional, Vollmar, Andrea, additional, Lesser, Michael B., additional, Van Israel, Nicole, additional, Lee, Pamela Ming‐Show, additional, Bulmer, Barret, additional, Santilli, Roberto, additional, Bossbaly, Maribeth J., additional, Quick, Nadine, additional, Bussadori, Claudio, additional, Bright, Janice, additional, Estrada, Amara H., additional, Ohad, Dan G., additional, del Palacio, Maria Josefa Fernández, additional, Brayley, Jennifer Lunney, additional, Schwartz, Denise S., additional, Gordon, Sonya G., additional, Jung, SeungWoo, additional, Bove, Christina M., additional, Brambilla, Paola G., additional, Moïse, N. Sydney, additional, Stauthammer, Christopher, additional, Quintavalla, Cecilia, additional, Manczur, Ferenc, additional, Stepien, Rebecca L., additional, Mooney, Carmel, additional, Hung, Yong‐Wei, additional, Lobetti, Remo, additional, Tamborini, Alice, additional, Oyama, Mark A., additional, Komolov, Andrey, additional, Fujii, Yoko, additional, Pariaut, Romain, additional, Uechi, Masami, additional, and Yukie Tachika Ohara, Victoria, additional

Published
2019
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33. Effects of pimobendan on left atrial transport function in cats.

Author

Kochie, Samantha L., Schober, Karsten E., Rhinehart, Jaylyn, Winter, Randolph L., Bonagura, John D., Showers, Annie, and Yildez, Vedat

Subjects
*LEFT heart atrium, *HYPERTROPHIC cardiomyopathy, *KINETIC energy, *ANALYSIS of variance, *THROMBOEMBOLISM
Abstract

Background: Arterial thromboembolism is a sequela of hypertrophic cardiomyopathy (HCM) in cats related to left atrial (LA) enlargement and dysfunction. Hypothesis: Pimobendan improves LA transport function in cats. Animals Twenty‐two client‐owned cats with HCM and 11 healthy cats. Methods: Prospective, double‐blind, randomized, placebo‐controlled clinical cohort study. Cats were randomized to receive either pimobendan (0.25 mg/kg PO q12h) or placebo for 4 to 7 days. Nineteen echocardiographic variables of LA size and function were evaluated. Statistical comparisons included t tests, analysis of variance, and multivariable analyses. Results: Peak velocity of left auricular appendage flow (LAapp peak; mean ± SD, 0.85 ± 0.20 vs 0.71 ± 0.22 m/s; P =.01), maximum LA volume (P =.03), LA total emptying volume (P =.03), peak velocity of late diastolic transmitral flow (A peak velocity; 0.77 ± 0.12 vs 0.62 ± 0.17 m/s; P =.05), and A velocity time integral (A VTI; 3.05 ± 0.69 vs 3.37 ± 0.49; P =.05) were increased after pimobendan. Mean change after pimobendan was larger in cats with HCM compared to healthy cats for LA fractional shortening (2.1% vs −2.1%; P =.05), A VTI (0.58 vs 0.01 cm; P =.01), LAapp peak (0.20 vs 0.02 m/s; P =.02), LA kinetic energy (3.51 vs −0.10 kdynes‐cm; P =.05), and LA ejection force (1.93 vs −0.07 kdynes; P =.01) in the multivariable model. The stronger effect of pimobendan in cats with HCM was independent of LA size. Conclusions and Clinical Importance: We identified positive, albeit minor, effects of pimobendan on LA function in cats with HCM. Whether or not treatment with pimobendan decreases the risk of cardiogenic embolism deserves further study. [ABSTRACT FROM AUTHOR]

Published
2021
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41. Effects of treatment on respiratory rate, serum natriuretic peptide concentration, and Doppler echocardiographic indices of left ventricular filling pressure in dogs with congestive heart failure secondary to degenerative mitral valve disease and dilated cardiomyopathy

Author

Schober, Karsten E., primary, Hart, Taye M., additional, Stern, Joshua A., additional, Li, Xiaobai, additional, Samii, Valerie F., additional, Zekas, Lisa J., additional, Scansen, Brian A., additional, and Bonagura, John D., additional

Published
2011
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