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1. Effect of Long‐Range Transported Fire Aerosols on Cloud Condensation Nuclei Concentrations and Cloud Properties at High Latitudes

Author

Kommula, S. M., primary, Buchholz, A., additional, Gramlich, Y., additional, Mielonen, T., additional, Hao, L., additional, Pullinen, I., additional, Vettikkat, L., additional, Ylisirniö, A., additional, Joutsensaari, J., additional, Schobesberger, S., additional, Tiitta, P., additional, Leskinen, A., additional, Rees, D. Hesslin‐, additional, Haslett, S. L., additional, Siegel, K., additional, Lunder, C., additional, Zieger, P., additional, Krejci, R., additional, Romakkaniemi, S., additional, Mohr, C., additional, and Virtanen, A., additional

Published
2024
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2. Effect of dimethylamine on the gas phase sulfuric acid concentration measured by Chemical Ionization Mass Spectrometry

Author

Rondo, L, Ehrhart, S, Kürten, A, Adamov, A, Bianchi, F, Breitenlechner, M, Duplissy, J, Franchin, A, Dommen, J, Donahue, NM, Dunne, EM, Flagan, RC, Hakala, J, Hansel, A, Keskinen, H, Kim, J, Jokinen, T, Lehtipalo, K, Leiminger, M, Praplan, A, Riccobono, F, Rissanen, MP, Sarnela, N, Schobesberger, S, Simon, M, Sipilä, M, Smith, JN, Tomé, A, Tröstl, J, Tsagkogeorgas, G, Vaattovaara, P, Winkler, PM, Williamson, C, Wimmer, D, Baltensperger, U, Kirkby, J, Kulmala, M, Petäjä, T, Worsnop, DR, and Curtius, J

Subjects
Earth Sciences, Atmospheric Sciences, CLOUD experiment, nucleation, Chemical Ionization-Atmospheric Pressure interface-Time Of Flight Mass Spectrometer, Chemical Ionization‐Atmospheric Pressure interface‐Time Of Flight Mass Spectrometer, Physical Geography and Environmental Geoscience, Atmospheric sciences, Climate change science
Abstract

Sulfuric acid is widely recognized as a very important substance driving atmospheric aerosol nucleation. Based on quantum chemical calculations it has been suggested that the quantitative detection of gas phase sulfuric acid (H2SO4) by use of Chemical Ionization Mass Spectrometry (CIMS) could be biased in the presence of gas phase amines such as dimethylamine (DMA). An experiment (CLOUD7 campaign) was set up at the CLOUD (Cosmics Leaving OUtdoor Droplets) chamber to investigate the quantitative detection of H2SO4 in the presence of dimethylamine by CIMS at atmospherically relevant concentrations. For the first time in the CLOUD experiment, the monomer sulfuric acid concentration was measured by a CIMS and by two CI-APi-TOF (Chemical Ionization-Atmospheric Pressure interface-Time Of Flight) mass spectrometers. In addition, neutral sulfuric acid clusters were measured with the CI-APi-TOFs. The CLOUD7 measurements show that in the presence of dimethylamine (

Published
2016

7. Effect of ions on sulfuric acid-water binary particle formation: 2. Experimental data and comparison with QC-normalized classical nucleation theory

Author

Duplissy J., Merikanto J., Franchin A., Tsagkogeorgas G., Kangasluoma J., Wimmer D., Vuollekoski H., Schobesberger S., Lehtipalo K., Flagan R. C., Brus D., Donahue N. M., Vehkamäki H., Almeida J., Amorim A., Barmet P., Bianchi F., Breitenlechner M., Dunne E. M., Guida R., Henschel H., Junninen H., Kirkby J., Kürten A., and Kupc A.

Published
2016
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9. T-tubule remodelling disturbs localised β2-adrenergic signalling in rat ventricular myocyte during the progression of heart failure

Author

Schobesberger, S, Wright, P, Tokar, S, Bhargava, A, Mansfield, C, Glukhov, AV, Poulet, C, Buzuk, A, Monszpart, A, Sikkel, M, Harding, SE, Nikolaev, VO, Lyon, AR, Gorelik, J, and British Heart Foundation

Subjects
Cardiovascular System & Hematology, Scanning ion conductance microscopy, T-tubules, Remodelling, Heart failure, Hypertrophy, β-Adrenoreceptor signalling, 1102 Cardiovascular Medicine And Haematology
Abstract

Aims Cardiomyocyte β2-adrenergic receptor (β2AR) cyclic adenosine monophosphate (cAMP) signalling is regulated by the receptors’ subcellular location within transverse tubules (T-tubules), via interaction with structural and regulatory proteins, which form a signalosome. In chronic heart failure (HF), β2ARs redistribute from T-tubules to the cell surface, which disrupts functional signalosomes and leads to diffuse cAMP signalling. However, the functional consequences of structural changes upon β2AR-cAMP signalling during progression from hypertrophy to advanced HF are unknown. Methods and results Rat left ventricular myocytes were isolated at 4-, 8-, and 16-week post-myocardial infarction (MI), β2ARs were stimulated either via whole-cell perfusion or locally through the nanopipette of the scanning ion conductance microscope. cAMP release was measured via a Förster Resonance Energy Transfer-based sensor Epac2-camps. Confocal imaging of di-8-ANNEPS-stained cells and immunoblotting were used to determine structural alterations. At 4-week post-MI, T-tubule regularity, density and junctophilin-2 (JPH2) expression were significantly decreased. The amplitude of local β2AR-mediated cAMP in T-tubules was reduced and cAMP diffused throughout the cytosol instead of being locally confined. This was accompanied by partial caveolin-3 (Cav-3) dissociation from the membrane. At 8-week post-MI, the β2AR-mediated cAMP response was observed at the T-tubules and the sarcolemma (crest). Finally, at 16-week post-MI, the whole cell β2AR-mediated cAMP signal was depressed due to adenylate cyclase dysfunction, while overall Cav-3 levels were significantly increased and a substantial portion of Cav-3 dissociated into the cytosol. Overexpression of JPH2 in failing cells in vitro or AAV9.SERCA2a gene therapy in vivo did not improve β2AR-mediated signal compartmentation or reduce cAMP diffusion. Conclusion Although changes in T-tubule structure and β2AR-mediated cAMP signalling are significant even at 4-week post-MI, progression to the HF phenotype is not linear. At 8-week post-MI the loss of β2AR-mediated cAMP is temporarily reversed. Complete disorganization of β2AR-mediated cAMP signalling due to changes in functional receptor localization and cellular structure occurs at 16-week post-MI.

Published
2017

10. Microdomain-Specific Modulation of L-type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure

Author

Sanchez-Alonso, JL, Bhargava, A, O'Hara, T, Glukhov, AV, Schobesberger, S, Bhogal, NK, Sikkel, MB, Mansfield, C, Korchev, YE, Lyon, AR, Punjabi, PP, Nikolaev, VO, Trayanova, NA, Gorelik, J, Wellcome Trust, British Heart Foundation, and Medical Research Council (MRC)

Subjects
Cardiovascular System & Hematology, L-type calcium channels, microdomain, heart failure, modeling, 1103 Clinical Sciences, super-resolution scanning patch-clamp, 1102 Cardiovascular Medicine And Haematology
Abstract

RATIONALE: Disruption in subcellular targeting of Ca(2+) signaling complexes secondary to changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of cardiac diseases, including heart failure (HF) and certain arrhythmias. OBJECTIVE: To explore microdomain-targeted remodeling of ventricular L-type Ca(2+) channels (LTCCs) in HF. METHODS AND RESULTS: Super-resolution scanning patch-clamp, confocal and fluorescence microscopy were used to explore distribution of single LTCCs in different membrane microdomains of non-failing and failing human and rat ventricular myocytes. Disruption of membrane structure in both species led to re-distribution of functional LTCCs from their canonical location in transversal tubules (T-tubules) to the non-native crest of the sarcolemma, where their open probability (Po) was dramatically increased (0.034±0.011 vs 0.154±0.027, P

Published
2016

11. Effect of ions on sulfuric acid-water binary particle formation II: Experimental data and comparison with QC-normalized classical nucleation theory

Author

Duplissy, Jonathan, Merikanto, J., Franchin, A., Tsagkogeorgas, G., Kangasluoma, J., Wimmer, D., Vuollekoski, H., Schobesberger, S., Lehtipalo, K., Flagan, R.C., Brus, D., Donahue, N.M., Vehkämäki, H., Almeida, J., Amorim, A., Barmet, P., Bianchi, F., Breitenlechner, M., Dunne, E.M., Guida, R., Henschel, H., Junninen, H., Kirkby, J., Kürten, A., Kupc, A., Määttänen, Anni, Makhmutov, V., Mathot, S., Nieminen, T., Onnela, A., Praplan, A.P., Riccobono, F., Rondo, L., Steiner, G., Tome, A., Walther, H., Baltensperger, U., Carslaw, K.S., Dommen, J., Hansel, A., Petäjä, T., Sipilä, M., Stratmann, F., Vrtala, A., Wagner, P.E., Worsnop, D.R., Curtius, J., Kulmala, M., Helsinki Institute of Physics (HIP), University of Helsinki, Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Finnish Meteorological Institute (FMI), Leibniz Institute for Tropospheric Research (TROPOS), Institute for Atmospheric and Environmental Sciences [Frankfurt/Main] (IAU), Goethe-University Frankfurt am Main, Department of Atmospheric Sciences [Seattle], University of Washington [Seattle], Departments of Environmental Science and Engineering and Chemical Engineering, California Institute of Technology (CALTECH), Center for Atmospheric Particle Studies [Pittsburgh] (CAPS), Carnegie Mellon University [Pittsburgh] (CMU), CERN Theoretical Physics Department, CERN [Genève], CENTRA-SIM, IDL-Faculdade de Ciencias da Universidade de Lisboa, Laboratory of Atmospheric Chemistry [Paul Scherrer Institute] (LAC), Paul Scherrer Institute (PSI), Department Construction, Traffic and Environment, Canton of Aargau, Institute for Atmospheric and Climate Science [Zürich] (IAC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institut für Ionenphysik und Angewandte Physik - Institute for Ion Physics and Applied Physics [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, School of Earth and Environment [Leeds] (SEE), University of Leeds, Aerosol Physics and Environmental Physics [Vienna], University of Vienna [Vienna], PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Solar and Cosmic Ray Research Laboratory [Moscow], P. N. Lebedev Physical Institute of the Russian Academy of Sciences [Moscow] (LPI RAS), Russian Academy of Sciences [Moscow] (RAS)-Russian Academy of Sciences [Moscow] (RAS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, and Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki

Subjects
[PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], binary particle formation, ion-induced nucleation, sulfuric acid, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], classical nucleation theory
Abstract

International audience; We report comprehensive, demonstrably contaminant-free measurements of binary particle formation rates by sulfuric acid and water for neutral and ion-induced pathways conducted in the European Organization for Nuclear Research Cosmics Leaving Outdoor Droplets chamber. The recently developed Atmospheric Pressure interface-time of flight-mass spectrometer was used to detect contaminants in charged clusters and to identify runs free of any contaminants. Four parameters were varied to cover ambient conditions: sulfuric acid concentration (105 to 109 mol cm−3), relative humidity (11% to 58%), temperature (207 K to 299 K), and total ion concentration (0 to 6800 ions cm−3). Formation rates were directly measured with novel instruments at sizes close to the critical cluster size (mobility size of 1.3 nm to 3.2 nm). We compare our results with predictions from Classical Nucleation Theory normalized by Quantum Chemical calculation (QC-normalized CNT), which is described in a companion paper. The formation rates predicted by the QC-normalized CNT were extended from critical cluster sizes to measured sizes using the UHMA2 sectional particle microphysics model. Our results show, for the first time, good agreement between predicted and measured particle formation rates for the binary (neutral and ion-induced) sulfuric acid-water system. Formation rates increase with RH, sulfuric acid, and ion concentrations and decrease with temperature at fixed RH and sulfuric acid concentration. Under atmospheric conditions, neutral particle formation dominates at low temperatures, while ion-induced particle formation dominates at higher temperatures. The good agreement between the theory and our comprehensive data set gives confidence in using the QC-normalized CNT as a powerful tool to study neutral and ion-induced binary particle formation in atmospheric modeling.

Published
2016
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12. Hygroscopicity of nanoparticles produced from homogeneous nucleation in the CLOUD experiments

Author

Kim, J., Ahlm, Lars, Yli-Juuti, T., Lawler, M., Keskinen, H., Tröstl, J., Schobesberger, S., Duplissy, J., Amorim, A., Bianchi, F., Donahue, N. M., Flagan, R. C., Hakala, J., Heinritzi, M., Jokinen, T., Kürten, A., Laaksonen, A., Lehtipalo, K., Miettinen, P., Petäjä, T., Rissanen, M. P., Rondo, L., Sengupta, K., Simon, M., Tomé, A., Williamson, C., Wimmer, D., Winkler, P. M., Ehrhart, S., Ye, P., Kirkby, J., Curtius, J., Baltensperger, U., Kulmala, M., Lehtinen, K. E. J., Smith, J. N., Riipinen, Ilona, Virtanen, A., Kim, J., Ahlm, Lars, Yli-Juuti, T., Lawler, M., Keskinen, H., Tröstl, J., Schobesberger, S., Duplissy, J., Amorim, A., Bianchi, F., Donahue, N. M., Flagan, R. C., Hakala, J., Heinritzi, M., Jokinen, T., Kürten, A., Laaksonen, A., Lehtipalo, K., Miettinen, P., Petäjä, T., Rissanen, M. P., Rondo, L., Sengupta, K., Simon, M., Tomé, A., Williamson, C., Wimmer, D., Winkler, P. M., Ehrhart, S., Ye, P., Kirkby, J., Curtius, J., Baltensperger, U., Kulmala, M., Lehtinen, K. E. J., Smith, J. N., Riipinen, Ilona, and Virtanen, A.

Abstract

Sulfuric acid, amines and oxidized organics have been found to be important compounds in the nucleation and initial growth of atmospheric particles. Because of the challenges involved in determining the chemical composition of objects with very small mass, however, the properties of the freshly nucleated particles and the detailed pathways of their formation processes are still not clear. In this study,we focus on a challenging size range, i.e., particles that have grown to diameters of 10 and 15 nm following nucleation, and measure their water uptake. Water uptake is useful information for indirectly obtaining chemical composition of aerosol particles. We use a nanometer-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) at sub-saturated conditions (ca. 90% relative humidity at 293 K) to measure the hygroscopicity of particles during the seventh Cosmics Leaving OUtdoor Droplets (CLOUD7) campaign performed at CERN in 2012. In CLOUD7, the hygroscopicity of nucleated nanoparticles was measured in the presence of sulfuric acid, sulfuric acid-dimethylamine, and sulfuric acid-organics derived from alpha-pinene oxidation. The hygroscopicity parameter kappa decreased with increasing particle size, indicating decreasing acidity of particles. No clear effect of the sulfuric acid concentration on the hygroscopicity of 10 nm particles produced from sulfuric acid and dimethylamine was observed, whereas the hygroscopicity of 15 nm particles sharply decreased with decreasing sulfuric acid concentrations. In particular, when the concentration of sulfuric acid was 5.1 x 10(6) molecules cm(-3) in the gas phase, and the dimethylamine mixing ratio was 11.8 ppt, the measured kappa of 15 nm particles was 0.31 +/- 0.01: close to the value reported for dimethylaminium sulfate (DMAS) (kappa(DMAS) similar to 0.28). Furthermore, the difference in kappa between sulfuric acid and sulfuric acid-dimethylamine experiments increased with increasing particle size. The kappa values of

Published
2016
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13. Modeling the thermodynamics and kinetics of sulfuric acid-dimethylamine-water nanoparticle growth in the CLOUD chamber

Author

Ahlm, Lars, Yli-Juuti, T., Schobesberger, S., Praplan, A. P., Kim, J., Tikkanen, O. -P., Lawler, M. J., Smith, J. N., Trostl, J., Acosta Navarro, Juan Camilo, Baltensperger, U., Bianchi, F., Donahue, N. M., Duplissy, J., Franchin, A., Jokinen, T., Keskinen, H., Kirkby, J., Kuerten, A., Laaksonen, A., Lehtipalo, K., Petaja, T., Riccobono, F., Rissanen, M. P., Rondo, L., Schallhart, S., Simon, M., Winkler, P. M., Worsnop, D. R., Virtanen, A., Riipinen, I., Ahlm, Lars, Yli-Juuti, T., Schobesberger, S., Praplan, A. P., Kim, J., Tikkanen, O. -P., Lawler, M. J., Smith, J. N., Trostl, J., Acosta Navarro, Juan Camilo, Baltensperger, U., Bianchi, F., Donahue, N. M., Duplissy, J., Franchin, A., Jokinen, T., Keskinen, H., Kirkby, J., Kuerten, A., Laaksonen, A., Lehtipalo, K., Petaja, T., Riccobono, F., Rissanen, M. P., Rondo, L., Schallhart, S., Simon, M., Winkler, P. M., Worsnop, D. R., Virtanen, A., and Riipinen, I.

Abstract

Dimethylamine (DMA) has a stabilizing effect on sulfuric acid (SA) clusters, and the SA and DMA molecules and clusters likely play important roles in both aerosol particle formation and growth in the atmosphere. We use the monodisperse particle growth model for acid-base chemistry in nanoparticle growth (MABNAG) together with direct and indirect observations from the CLOUD4 and CLOUD7 experiments in the cosmics leaving outdoor droplets (CLOUD) chamber at CERN to investigate the size and composition evolution of freshly formed particles consisting of SA, DMA, and water as they grow to 20nm in dry diameter. Hygroscopic growth factors are measured using a nano-hygroscopicity tandem differential mobility analyzer (nano-HTDMA), which combined with simulations of particle water uptake using the thermodynamic extended-aerosol inorganics model (E-AIM) constrain the chemical composition. MABNAG predicts a particle-phase ratio between DMA and SA molecules of 1.1-1.3 for a 2nm particle and DMA gas-phase mixing ratios between 3.5 and 80 pptv. These ratios agree well with observations by an atmospheric-pressure interface time-of-flight (APi-TOF) mass spectrometer. Simulations with MABNAG, direct observations of the composition of clusters <2nm, and indirect observations of the particle composition indicate that the acidity of the nucleated particles decreases as they grow from approximate to 1 to 20nm. However, MABNAG predicts less acidic particles than suggested by the indirect estimates at 10nm diameter using the nano-HTDMA measurements, and less acidic particles than observed by a thermal desorption chemical ionization mass spectrometer (TDCIMS) at 10-30nm. Possible explanations for these discrepancies are discussed.

Published
2016
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14. Effect of ions on sulfuric acid-water binary particle formation : 2. Experimental data and comparison with QC-normalized classical nucleation theory

Author

Duplissy, J., Merikanto, J., Franchin, A., Tsagkogeorgas, G., Kangasluoma, J., Wimmer, D., Vuollekoski, H., Schobesberger, S., Lehtipalo, K., Flagan, R. C., Brus, D., Donahue, N. M., Vehkamaki, H., Almeida, J., Amorim, A., Barmet, P., Bianchi, F., Breitenlechner, M., Dunne, E. M., Guida, R., Henschel, Henning, Junninen, H., Kirkby, J., Kuerten, A., Kupc, A., Maattanen, A., Makhmutov, V., Mathot, S., Nieminen, T., Onnela, A., Praplan, A. P., Riccobono, F., Rondo, L., Steiner, G., Tome, A., Walther, H., Baltensperger, U., Carslaw, K. S., Dommen, J., Hansel, A., Petaja, T., Sipila, M., Stratmann, F., Vrtala, A., Wagner, P. E., Worsnop, D. R., Curtius, J., Kulmala, M., Duplissy, J., Merikanto, J., Franchin, A., Tsagkogeorgas, G., Kangasluoma, J., Wimmer, D., Vuollekoski, H., Schobesberger, S., Lehtipalo, K., Flagan, R. C., Brus, D., Donahue, N. M., Vehkamaki, H., Almeida, J., Amorim, A., Barmet, P., Bianchi, F., Breitenlechner, M., Dunne, E. M., Guida, R., Henschel, Henning, Junninen, H., Kirkby, J., Kuerten, A., Kupc, A., Maattanen, A., Makhmutov, V., Mathot, S., Nieminen, T., Onnela, A., Praplan, A. P., Riccobono, F., Rondo, L., Steiner, G., Tome, A., Walther, H., Baltensperger, U., Carslaw, K. S., Dommen, J., Hansel, A., Petaja, T., Sipila, M., Stratmann, F., Vrtala, A., Wagner, P. E., Worsnop, D. R., Curtius, J., and Kulmala, M.

Published
2016
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15. Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart FailureNovelty and Significance

Author

Sanchez-Alonso, J L, Bhargava, Anamika, O’Hara, T, Glukhov, A V, Schobesberger, S, Bhogal, N, Sikkel, M B, Mansfield, C, Korchev, Y E, Lyon, A R, Punjabi, P P, Nikolaev, V O, Trayanova, N A, Gorelik, J, Sanchez-Alonso, J L, Bhargava, Anamika, O’Hara, T, Glukhov, A V, Schobesberger, S, Bhogal, N, Sikkel, M B, Mansfield, C, Korchev, Y E, Lyon, A R, Punjabi, P P, Nikolaev, V O, Trayanova, N A, and Gorelik, J

Abstract

Methods and Results: Super-resolution scanning patch-clamp, confocal and fluorescence microscopy were used to explore the distribution of single LTCCs in different membrane microdomains of nonfailing and failing human and rat ventricular myocytes. Disruption of membrane structure in both species led to the redistribution of functional LTCCs from their canonical location in transversal tubules (T-tubules) to the non-native crest of the sarcolemma, where their open probability was dramatically increased (0.034 +/- 0.011 versus 0.154 +/- 0.027, P<0.001). High open probability was linked to enhance calcium-calmodulin kinase II-mediated phosphorylation in nonnative microdomains and resulted in an elevated I-Ca,I-L window current, which contributed to the development of early afterdepolarizations. A novel model of LTCC function in HF was developed; after its validation with experimental data, the model was used to ascertain how HF-induced T-tubule loss led to altered LTCC function and early afterdepolarizations. The HF myocyte model was then implemented in a 3-dimensional left ventricle model, demonstrating that such early afterdepolarizations can propagate and initiate reentrant arrhythmias.

Published
2016

16. Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes

Author

Miragoli, M, Sanchez-Alonso, J L, Bhargava, Anamika, Wright, P T, Sikkel, M, Schobesberger, S, Diakonov, I, Novak, P, Castaldi, A, Cattaneo, P, Lyon, A R, Lab, M J, Gorelik, J, Miragoli, M, Sanchez-Alonso, J L, Bhargava, Anamika, Wright, P T, Sikkel, M, Schobesberger, S, Diakonov, I, Novak, P, Castaldi, A, Cattaneo, P, Lyon, A R, Lab, M J, and Gorelik, J

Abstract

Arrhythmogenesis during heart failure is a major clinical problem. Regional electrical gradients produce arrhythmias, and cellular ionic transmembrane gradients are its originators. We investigated whether the nanoscale mechanosensitive properties of cardiomyocytes from failing hearts have a bearing upon the initiation of abnormal electrical activity. Hydrojets through a nanopipette indent specific locations on the sarcolemma and initiate intracellular calcium release in both healthy and heart failure cardiomyocytes, as well as in human failing cardiomyocytes. In healthy cells, calcium is locally confined, whereas in failing cardiomyocytes, calcium propagates. Heart failure progressively stiffens the membrane and displaces sub-sarcolemmal mitochondria. Colchicine in healthy cells mimics the failing condition by stiffening the cells, disrupting microtubules, shifting mitochondria, and causing calcium release. Uncoupling the mitochondrial proton gradient abolished calcium initiation in both failing and colchicine-treated cells. We propose the disruption of microtubule-dependent mitochondrial mechanosensor microdomains as a mechanism for abnormal calcium release in failing heart.

Published
2016

17. Modeling the thermodynamics and kinetics of sulfuric acid-dimethylamine-water nanoparticle growth in the CLOUD chamber

Author

Ahlm, L., primary, Yli-Juuti, T., additional, Schobesberger, S., additional, Praplan, A. P., additional, Kim, J., additional, Tikkanen, O.-P., additional, Lawler, M. J., additional, Smith, J. N., additional, Tröstl, J., additional, Acosta Navarro, J. C., additional, Baltensperger, U., additional, Bianchi, F., additional, Donahue, N. M., additional, Duplissy, J., additional, Franchin, A., additional, Jokinen, T., additional, Keskinen, H., additional, Kirkby, J., additional, Kürten, A., additional, Laaksonen, A., additional, Lehtipalo, K., additional, Petäjä, T., additional, Riccobono, F., additional, Rissanen, M. P., additional, Rondo, L., additional, Schallhart, S., additional, Simon, M., additional, Winkler, P. M., additional, Worsnop, D. R., additional, Virtanen, A., additional, and Riipinen, I., additional

Published
2016
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19. Direct Observations of Atmospheric Aerosol Nucleation

Author

Kulmala M, Kontkanen J, Junninen H, Lehtipalo K, Manninen HE, Nieminen T, Petaja T, Sipila M, Sipila Mikko, Schobesberger S, Rantala P, Franchin A, Jokinen T, Jarvinen E, Aijala M, Kangasluoma J, Hakala J, Aalto PP, Paasonen P, Mikkila J, Vanhanen J, Aalto J, Hakola H, Makkonen U, Ruuskanen T, Mauldin RL, Duplissy J, Vehkamaki H, Back J, Kortelainen A, Riipinen I, Kurten T, Johnston MV, Smith JN, Ehn M, Mentel TF, Lehtinen KEJ, Laaksonen A, Kerminen VM, and Worsnop

Published
2013

20. Hygroscopicity of nanoparticles produced from homogeneous nucleation in the CLOUD experiments

Author

Kim, J., primary, Ahlm, L., additional, Yli-Juuti, T., additional, Lawler, M., additional, Keskinen, H., additional, Tröstl, J., additional, Schobesberger, S., additional, Duplissy, J., additional, Amorim, A., additional, Bianchi, F., additional, Donahue, N. M., additional, Flagan, R. C., additional, Hakala, J., additional, Heinritzi, M., additional, Jokinen, T., additional, Kürten, A., additional, Laaksonen, A., additional, Lehtipalo, K., additional, Miettinen, P., additional, Petäjä, T., additional, Rissanen, M. P., additional, Rondo, L., additional, Sengupta, K., additional, Simon, M., additional, Tomé, A., additional, Williamson, C., additional, Wimmer, D., additional, Winkler, P. M., additional, Ehrhart, S., additional, Ye, P., additional, Kirkby, J., additional, Curtius, J., additional, Baltensperger, U., additional, Kulmala, M., additional, Lehtinen, K. E. J., additional, Smith, J. N., additional, Riipinen, I., additional, and Virtanen, A., additional

Published
2016
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21. Elemental composition and clustering behaviour of alpha-pinene oxidation products for different oxidation conditions

Author

University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics, Praplan, A. P., Schobesberger, S., Bianchi, F., Rissanen, M. P., Ehn, M., Jokinen, Tuija, Junninen, H., Adamov, A., Amorim, A., Dommen, J., Duplissy, J., Hakala, J., Hansel, A., Heinritzi, M., Kangasluoma, J., Kirkby, J., Krapf, M., Kürten, A., Lehtipalo, K., Riccobono, F., Rondo, L., Sarnela, N., Simon, M., Tome, A., Tröstl, J., Winkler, P. M., Williamson, C., Ye, P., Curtius, J., Baltensperger, U., Donahue, N. M., Kulmala, Markku, Worsnop, D. R., University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics, Praplan, A. P., Schobesberger, S., Bianchi, F., Rissanen, M. P., Ehn, M., Jokinen, Tuija, Junninen, H., Adamov, A., Amorim, A., Dommen, J., Duplissy, J., Hakala, J., Hansel, A., Heinritzi, M., Kangasluoma, J., Kirkby, J., Krapf, M., Kürten, A., Lehtipalo, K., Riccobono, F., Rondo, L., Sarnela, N., Simon, M., Tome, A., Tröstl, J., Winkler, P. M., Williamson, C., Ye, P., Curtius, J., Baltensperger, U., Donahue, N. M., Kulmala, Markku, and Worsnop, D. R.

Abstract

This study presents the difference between oxidised organic compounds formed by alpha-pinene oxidation under various conditions in the CLOUD environmental chamber: (1) pure ozonolysis (in the presence of hydrogen as hydroxyl radical (OH) scavenger) and (2) OH oxidation (initiated by nitrous acid (HONO) photolysis by ultraviolet light) in the absence of ozone. We discuss results from three Atmospheric Pressure interface Time-of-Flight (APi-TOF) mass spectrometers measuring simultaneously the composition of naturally charged as well as neutral species (via chemical ionisation with nitrate). Natural chemical ionisation takes place in the CLOUD chamber and organic oxidised compounds form clusters with nitrate, bisulfate, bisulfate/sulfuric acid clusters, ammonium, and dimethylaminium, or get protonated. The results from this study show that this process is selective for various oxidised organic compounds with low molar mass and ions, so that in order to obtain a comprehensive picture of the elemental composition of oxidation products and their clustering behaviour, several instruments must be used. We compare oxidation products containing 10 and 20 carbon atoms and show that highly oxidised organic compounds are formed in the early stages of the oxidation.

Published
2015

22. On the composition of ammonia-sulfuric-acid ion clusters during aerosol particle formation

Author

University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics, Schobesberger, S., Franchin, A., Bianchi, F., Rondo, L., Duplissy, J., Kuerten, A., Ortega Colomer, Ismael Kenneth, Metzger, A., Schnitzhofer, R., Almeida, J., Amorim, A., Dommen, J., Dunne, E. M., Ehn, M., Gagne, S., Ickes, L., Junninen, H., Hansel, A., Kerminen, V-M, Kirkby, J., Kupc, A., Laaksonen, A., Lehtipalo, K., Mathot, S., Onnela, A., Petaja, T., Riccobono, F., Santos, F. D., Sipila, M., Tome, A., Tsagkogeorgas, G., Viisanen, Y., Wagner, P. E., Wimmer, D., Curtius, J., Donahue, N. M., Baltensperger, U., Kulmala, M., Worsnop, D. R., University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics, Schobesberger, S., Franchin, A., Bianchi, F., Rondo, L., Duplissy, J., Kuerten, A., Ortega Colomer, Ismael Kenneth, Metzger, A., Schnitzhofer, R., Almeida, J., Amorim, A., Dommen, J., Dunne, E. M., Ehn, M., Gagne, S., Ickes, L., Junninen, H., Hansel, A., Kerminen, V-M, Kirkby, J., Kupc, A., Laaksonen, A., Lehtipalo, K., Mathot, S., Onnela, A., Petaja, T., Riccobono, F., Santos, F. D., Sipila, M., Tome, A., Tsagkogeorgas, G., Viisanen, Y., Wagner, P. E., Wimmer, D., Curtius, J., Donahue, N. M., Baltensperger, U., Kulmala, M., and Worsnop, D. R.

Published
2015

23. Thermodynamics of the formation of sulfuric acid dimers in the binary (H&lt;sub&gt;2&lt;/sub&gt;SO&lt;sub&gt;4&lt;/sub&gt;–H&lt;sub&gt;2&lt;/sub&gt;O) and ternary (H&lt;sub&gt;2&lt;/sub&gt;SO&lt;sub&gt;4&lt;/sub&gt;–H&lt;sub&gt;2&lt;/sub&gt;O–NH&lt;sub&gt;3&lt;/sub&gt;) system

Author

Kürten, A., primary, Münch, S., additional, Rondo, L., additional, Bianchi, F., additional, Duplissy, J., additional, Jokinen, T., additional, Junninen, H., additional, Sarnela, N., additional, Schobesberger, S., additional, Simon, M., additional, Sipilä, M., additional, Almeida, J., additional, Amorim, A., additional, Dommen, J., additional, Donahue, N. M., additional, Dunne, E. M., additional, Flagan, R. C., additional, Franchin, A., additional, Kirkby, J., additional, Kupc, A., additional, Makhmutov, V., additional, Petäjä, T., additional, Praplan, A. P., additional, Riccobono, F., additional, Steiner, G., additional, Tomé, A., additional, Tsagkogeorgas, G., additional, Wagner, P. E., additional, Wimmer, D., additional, Baltensperger, U., additional, Kulmala, M., additional, Worsnop, D. R., additional, and Curtius, J., additional

Published
2015
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24. Hygroscopicity of nanoparticles produced from homogeneous nucleation in the CLOUD experiments

Author

Kim, J., primary, Ahlm, L., additional, Yli-Juuti, T., additional, Lawler, M., additional, Keskinen, H., additional, Tröstl, J., additional, Schobesberger, S., additional, Duplissy, J., additional, Amorim, A., additional, Bianchi, F., additional, Donahue, N. M., additional, Flagan, R. C., additional, Hakala, J., additional, Heinritzi, M., additional, Jokinen, T., additional, Kürten, A., additional, Laaksonen, A., additional, Lehtipalo, K., additional, Miettinen, P., additional, Petäjä, T., additional, Rissanen, M. P., additional, Rondo, L., additional, Sengupta, K., additional, Simon, M., additional, Tomé, A., additional, Williamson, C., additional, Wimmer, D., additional, Winkler, P. M., additional, Ehrhart, S., additional, Ye, P., additional, Kirkby, J., additional, Curtius, J., additional, Kulmala, M., additional, Lehtinen, K. E. J., additional, Smith, J. N., additional, Riipinen, I., additional, and Virtanen, A., additional

Published
2015
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25. Experimental investigation of ion–ion recombination under atmospheric conditions

Author

Franchin, A., primary, Ehrhart, S., additional, Leppä, J., additional, Nieminen, T., additional, Gagné, S., additional, Schobesberger, S., additional, Wimmer, D., additional, Duplissy, J., additional, Riccobono, F., additional, Dunne, E. M., additional, Rondo, L., additional, Downard, A., additional, Bianchi, F., additional, Kupc, A., additional, Tsagkogeorgas, G., additional, Lehtipalo, K., additional, Manninen, H. E., additional, Almeida, J., additional, Amorim, A., additional, Wagner, P. E., additional, Hansel, A., additional, Kirkby, J., additional, Kürten, A., additional, Donahue, N. M., additional, Makhmutov, V., additional, Mathot, S., additional, Metzger, A., additional, Petäjä, T., additional, Schnitzhofer, R., additional, Sipilä, M., additional, Stozhkov, Y., additional, Tomé, A., additional, Kerminen, V.-M., additional, Carslaw, K., additional, Curtius, J., additional, Baltensperger, U., additional, and Kulmala, M., additional

Published
2015
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26. Elemental composition and clustering behaviour of α-pinene oxidation products for different oxidation conditions

Author

Praplan, A. P., primary, Schobesberger, S., additional, Bianchi, F., additional, Rissanen, M. P., additional, Ehn, M., additional, Jokinen, T., additional, Junninen, H., additional, Adamov, A., additional, Amorim, A., additional, Dommen, J., additional, Duplissy, J., additional, Hakala, J., additional, Hansel, A., additional, Heinritzi, M., additional, Kangasluoma, J., additional, Kirkby, J., additional, Krapf, M., additional, Kürten, A., additional, Lehtipalo, K., additional, Riccobono, F., additional, Rondo, L., additional, Sarnela, N., additional, Simon, M., additional, Tomé, A., additional, Tröstl, J., additional, Winkler, P. M., additional, Williamson, C., additional, Ye, P., additional, Curtius, J., additional, Baltensperger, U., additional, Donahue, N. M., additional, Kulmala, M., additional, and Worsnop, D. R., additional

Published
2015
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27. Experimental investigation of ion-ion recombination at atmospheric conditions

Author

Franchin, A., primary, Ehrhart, S., additional, Leppä, J., additional, Nieminen, T., additional, Gagné, S., additional, Schobesberger, S., additional, Wimmer, D., additional, Duplissy, J., additional, Riccobono, F., additional, Dunne, E., additional, Rondo, L., additional, Downard, A., additional, Bianchi, F., additional, Kupc, A., additional, Tsagkogeorgas, G., additional, Lehtipalo, K., additional, Manninen, H. E., additional, Almeida, J., additional, Amorim, A., additional, Wagner, P. E., additional, Hansel, A., additional, Kirkby, J., additional, Kürten, A., additional, Donahue, N. M., additional, Makhmutov, V., additional, Mathot, S., additional, Metzger, A., additional, Petäjä, T., additional, Schnitzhofer, R., additional, Sipilä, M., additional, Stozhkov, Y., additional, Tomé, A., additional, Kerminen, V.-M., additional, Carslaw, K., additional, Curtius, J., additional, Baltensperger, U., additional, and Kulmala, M., additional

Published
2015
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28. On the composition of ammonia–sulfuric-acid ion clusters during aerosol particle formation

Author

Schobesberger, S., primary, Franchin, A., additional, Bianchi, F., additional, Rondo, L., additional, Duplissy, J., additional, Kürten, A., additional, Ortega, I. K., additional, Metzger, A., additional, Schnitzhofer, R., additional, Almeida, J., additional, Amorim, A., additional, Dommen, J., additional, Dunne, E. M., additional, Ehn, M., additional, Gagné, S., additional, Ickes, L., additional, Junninen, H., additional, Hansel, A., additional, Kerminen, V.-M., additional, Kirkby, J., additional, Kupc, A., additional, Laaksonen, A., additional, Lehtipalo, K., additional, Mathot, S., additional, Onnela, A., additional, Petäjä, T., additional, Riccobono, F., additional, Santos, F. D., additional, Sipilä, M., additional, Tomé, A., additional, Tsagkogeorgas, G., additional, Viisanen, Y., additional, Wagner, P. E., additional, Wimmer, D., additional, Curtius, J., additional, Donahue, N. M., additional, Baltensperger, U., additional, Kulmala, M., additional, and Worsnop, D. R., additional

Published
2015
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29. Elemental composition and clustering of α-pinene oxidation products for different oxidation conditions

Author

Praplan, A. P., primary, Schobesberger, S., additional, Bianchi, F., additional, Rissanen, M. P., additional, Ehn, M., additional, Jokinen, T., additional, Junninen, H., additional, Adamov, A., additional, Amorim, A., additional, Dommen, J., additional, Duplissy, J., additional, Hakala, J., additional, Hansel, A., additional, Heinritzi, M., additional, Kangasluoma, J., additional, Kirkby, J., additional, Krapf, M., additional, Kürten, A., additional, Lehtipalo, K., additional, Riccobono, F., additional, Rondo, L., additional, Sarnela, N., additional, Simon, M., additional, Tomé, A., additional, Tröstl, J., additional, Winkler, P. M., additional, Williamson, C., additional, Ye, P., additional, Curtius, J., additional, Baltensperger, U., additional, Donahue, N. M., additional, Kulmala, M., additional, and Worsnop, D. R., additional

Published
2014
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32. On the composition of ammonia-sulfuric acid clusters during aerosol particle formation

Author

Schobesberger, S., primary, Franchin, A., additional, Bianchi, F., additional, Rondo, L., additional, Duplissy, J., additional, Kürten, A., additional, Ortega, I. K., additional, Metzger, A., additional, Schnitzhofer, R., additional, Almeida, J., additional, Amorim, A., additional, Dommen, J., additional, Dunne, E. M., additional, Ehn, M., additional, Gagné, S., additional, Ickes, L., additional, Junninen, H., additional, Hansel, A., additional, Kerminen, V.-M., additional, Kirkby, J., additional, Kupc, A., additional, Laaksonen, A., additional, Lehtipalo, K., additional, Mathot, S., additional, Onnela, A., additional, Petäjä, T., additional, Riccobono, F., additional, Santos, F. D., additional, Sipilä, M., additional, Tomé, A., additional, Tsagkogeorgas, G., additional, Viisanen, Y., additional, Wagner, P. E., additional, Wimmer, D., additional, Curtius, J., additional, Donahue, N. M., additional, Baltensperger, U., additional, Kulmala, M., additional, and Worsnop, D. R., additional

Published
2014
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33. Prescribed burning of logging slash in the boreal forest of Finland: emissions and effects on meteorological quantities and soil properties

Author

Virkkula, A., primary, Levula, J., additional, Pohja, T., additional, Aalto, P. P., additional, Keronen, P., additional, Schobesberger, S., additional, Clements, C. B., additional, Pirjola, L., additional, Kieloaho, A.-J., additional, Kulmala, L., additional, Aaltonen, H., additional, Patokoski, J., additional, Pumpanen, J., additional, Rinne, J., additional, Ruuskanen, T., additional, Pihlatie, M., additional, Manninen, H. E., additional, Aaltonen, V., additional, Junninen, H., additional, Petäjä, T., additional, Backman, J., additional, Dal Maso, M., additional, Nieminen, T., additional, Olsson, T., additional, Grönholm, T., additional, Aalto, J., additional, Virtanen, T. H., additional, Kajos, M., additional, Kerminen, V.-M., additional, Schultz, D. M., additional, Kukkonen, J., additional, Sofiev, M., additional, De Leeuw, G., additional, Bäck, J., additional, Hari, P., additional, and Kulmala, M., additional

Published
2014
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34. Evolution of Nanoparticle Composition in CLOUD in Presence of Sulphuric Acid, Ammonia and Organics

Author

Keskinen, H., Virtanen, A., Joutsensaari, J., Tsagkogeorgas, G., Duplissy, J., Schobesberger, S., Gysel, M., Riccobono, F., Slowik, J. G., Bianchi, F., Yli-Juuti, T., Lehtipalo, K., Rondo, L., Breitenlechner, M., Kupc, A., Almeida, J., Amorim, A., Dunne, E. M., Downard, A. J., Ehrhart, S., Franchin, A., Kajos, M. K., Kirkby, J., Kuerten, A., Nieminen, T., Makhmutov, V., Mathot, S., Miettinen, P., Onnela, A., Petaja, T., Prapland, A., Santos, F. D., Schallhart, S., Sipila, M., Stozhkov, Y., Tome, A., Vaattovaara, P., Wimmer, D., Prevot, A., Dommen, J., Donahue, N. M., Flagan, R. C., Weingartner, E., Viisanen, Y., Riipinen, Ilona, Hansel, A., Curtius, J., Kulmala, M., Worsnop, D. R., Baltensperger, U., Wex, H., Stratmann, F., Laaksonen, A., Keskinen, H., Virtanen, A., Joutsensaari, J., Tsagkogeorgas, G., Duplissy, J., Schobesberger, S., Gysel, M., Riccobono, F., Slowik, J. G., Bianchi, F., Yli-Juuti, T., Lehtipalo, K., Rondo, L., Breitenlechner, M., Kupc, A., Almeida, J., Amorim, A., Dunne, E. M., Downard, A. J., Ehrhart, S., Franchin, A., Kajos, M. K., Kirkby, J., Kuerten, A., Nieminen, T., Makhmutov, V., Mathot, S., Miettinen, P., Onnela, A., Petaja, T., Prapland, A., Santos, F. D., Schallhart, S., Sipila, M., Stozhkov, Y., Tome, A., Vaattovaara, P., Wimmer, D., Prevot, A., Dommen, J., Donahue, N. M., Flagan, R. C., Weingartner, E., Viisanen, Y., Riipinen, Ilona, Hansel, A., Curtius, J., Kulmala, M., Worsnop, D. R., Baltensperger, U., Wex, H., Stratmann, F., and Laaksonen, A.

Abstract

In this study, we investigate the composition of nucleated nanoparticles formed from sulphuric acid, ammonia, amines, and oxidised organics in the CLOUD chamber experiments at CERN. The investigation is carried out via analysis of the particle hygroscopicity (size range of 15-63 nm), ethanol affinity (15-50nm), oxidation state (<50 nm), and ion composition (few nanometers). The organic volume fraction of particles increased with an increase in particle diameter in presence of the sulphuric acid, ammonia and organics. Vice versa, the sulphuric acid volume fraction decreased when the particle diameter increased. The results provide information on the size-dependent composition of nucleated aerosol particles.

Published
2013
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35. Overview of a prescribed burning experiment within a boreal forest in Finland

Author

Virkkula, A., primary, Levula, J., additional, Pohja, T., additional, Aalto, P. P., additional, Keronen, P., additional, Schobesberger, S., additional, Clements, C. B., additional, Pirjola, L., additional, Kieloaho, A.-J., additional, Kulmala, L., additional, Aaltonen, H., additional, Patokoski, J., additional, Pumpanen, J., additional, Rinne, J., additional, Ruuskanen, T., additional, Pihlatie, M., additional, Manninen, H. E., additional, Aaltonen, V., additional, Junninen, H., additional, Petäjä, T., additional, Backman, J., additional, Dal Maso, M., additional, Nieminen, T., additional, Olsson, T., additional, Grönholm, T., additional, Kerminen, V.-M., additional, Schultz, D. M., additional, Kukkonen, J., additional, Sofiev, M., additional, de Leeuw, G., additional, Bäck, J., additional, Hari, P., additional, and Kulmala, M., additional

Published
2013
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36. Evolution of particle composition in CLOUD nucleation experiments

Author

Keskinen, H., primary, Virtanen, A., additional, Joutsensaari, J., additional, Tsagkogeorgas, G., additional, Duplissy, J., additional, Schobesberger, S., additional, Gysel, M., additional, Riccobono, F., additional, Slowik, J. G., additional, Bianchi, F., additional, Yli-Juuti, T., additional, Lehtipalo, K., additional, Rondo, L., additional, Breitenlechner, M., additional, Kupc, A., additional, Almeida, J., additional, Amorim, A., additional, Dunne, E. M., additional, Downard, A. J., additional, Ehrhart, S., additional, Franchin, A., additional, Kajos, M.K., additional, Kirkby, J., additional, Kürten, A., additional, Nieminen, T., additional, Makhmutov, V., additional, Mathot, S., additional, Miettinen, P., additional, Onnela, A., additional, Petäjä, T., additional, Praplan, A., additional, Santos, F. D., additional, Schallhart, S., additional, Sipilä, M., additional, Stozhkov, Y., additional, Tomé, A., additional, Vaattovaara, P., additional, Wimmer, D., additional, Prevot, A., additional, Dommen, J., additional, Donahue, N. M., additional, Flagan, R.C., additional, Weingartner, E., additional, Viisanen, Y., additional, Riipinen, I., additional, Hansel, A., additional, Curtius, J., additional, Kulmala, M., additional, Worsnop, D. R., additional, Baltensperger, U., additional, Wex, H., additional, Stratmann, F., additional, and Laaksonen, A., additional

Published
2013
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37. Evolution of nanoparticle composition in CLOUD in presence of sulphuric acid, ammonia and organics

Author

Keskinen, H., primary, Virtanen, A., additional, Joutsensaari, J., additional, Tsagkogeorgas, G., additional, Duplissy, J., additional, Schobesberger, S., additional, Gysel, M., additional, Riccobono, F., additional, Slowik, J. G., additional, Bianchi, F., additional, Yli-Juuti, T., additional, Lehtipalo, K., additional, Rondo, L., additional, Breitenlechner, M., additional, Kupc, A., additional, Almeida, J., additional, Amorim, A., additional, Dunne, E. M., additional, Downard, A. J., additional, Ehrhart, S., additional, Franchin, A., additional, Kajos, M. K., additional, Kirkby, J., additional, Kürten, A., additional, Nieminen, T., additional, Makhmutov, V., additional, Mathot, S., additional, Miettinen, P., additional, Onnela, A., additional, Petäjä, T., additional, Praplan, A., additional, Santos, F. D., additional, Schallhart, S., additional, Sipilä, M., additional, Stozhkov, Y., additional, Tomé, A., additional, Vaattovaara, P., additional, Wimmer, D., additional, Prevot, A., additional, Dommen, J., additional, Donahue, N. M., additional, Flagan, R. C., additional, Weingartner, E., additional, Viisanen, Y., additional, Riipinen, I., additional, Hansel, A., additional, Curtius, J., additional, Kulmala, M., additional, Worsnop, D. R., additional, Baltensperger, U., additional, Wex, H., additional, Stratmann, F., additional, and Laaksonen, A., additional

Published
2013
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38. Evolution of particle composition in CLOUD nucleation experiments

Author

Keskinen, H., primary, Virtanen, A., additional, Joutsensaari, J., additional, Tsagkogeorgas, G., additional, Duplissy, J., additional, Schobesberger, S., additional, Gysel, M., additional, Riccobono, F., additional, Slowik, J. G., additional, Bianchi, F., additional, Yli-Juuti, T., additional, Lehtipalo, K., additional, Rondo, L., additional, Breitenlechner, M., additional, Kupc, A., additional, Almeida, J., additional, Amorin, A., additional, Dunne, E. M., additional, Downward, A. J., additional, Ehrhart, S., additional, Franchin, A., additional, Kajos, M. K., additional, Kirkby, J., additional, Kürten, A., additional, Nieminen, T., additional, Makhmutov, V., additional, Mathot, S., additional, Miettinen, P., additional, Onnela, A., additional, Petäjä, T., additional, Praplan, A., additional, Santos, F. D., additional, Schallhart, S., additional, Sipilä, M., additional, Stozhkov, Y., additional, Tomé, A., additional, Vaattovaara, P., additional, Wimmer, D., additional, Prévôt, A., additional, Dommen, J., additional, Donahue, N. M., additional, Flagan, R. C., additional, Weingartner, E., additional, Viisanen, Y., additional, Riipinen, I., additional, Hansel, A., additional, Curtius, J., additional, Kulmala, M., additional, Worsnop, D. R., additional, Baltensperger, U., additional, Wex, H., additional, Stratmann, F., additional, and Laaksonen, A., additional

Published
2012
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40. Oral abstract presentations & Young Investigators Competition

Author

Leone, A., primary, Aquila, I., additional, Vicinanza, C., additional, Iaconetti, C., additional, Bochicchio, A., additional, Ottolenghi, S., additional, Indolfi, C., additional, Nadal-Ginard, B., additional, Ellison, G. M., additional, Torella, D., additional, Mias, C., additional, Genet, G., additional, Guilbeau-Frugier, C., additional, Pathak, A., additional, Senard, J. M., additional, Gales, C., additional, Egorova, A. D., additional, Khedoe, P. S. J., additional, Goumans, M. T. H., additional, Nauli, S. M., additional, Ten Dijke, P., additional, Poelmann, R. E., additional, Hierck, B. P., additional, Miragoli, M., additional, Lab, M. J., additional, Singh, A., additional, Sikkel, M., additional, Lyon, A., additional, Gorelik, J., additional, Cheung, C., additional, Bernardo, A. S., additional, Trotter, M. W., additional, Pedersen, R. A., additional, Sinha, S., additional, Mioulane, M., additional, Foldes, G., additional, Harding, S. E., additional, Reglin, B., additional, Secomb, T. W., additional, Pries, A. R., additional, Buckingham, M., additional, Lescroart, F., additional, Meilhac, S., additional, Le Garrec, J.-F., additional, Rozmaritsa, N., additional, Christ, T., additional, Wettwer, E., additional, Knaut, M., additional, Ravens, U., additional, Tokar, S., additional, Schobesberger, S., additional, Wright, P. T., additional, Lyon, A. R., additional, Van Mil, A., additional, Grundmann, S., additional, Goumans, M.-J., additional, Jaksani, S., additional, Doevendans, P. A., additional, Sluijter, J. P., additional, Tijsen, A. J., additional, Amin, A. S., additional, Giudicessi, J. R., additional, Tanck, M. W., additional, Bezzina, C. R., additional, Creemers, E. E., additional, Wilde, A. M., additional, Ackerman, M. J., additional, Pinto, Y. M., additional, Gedicke-Hornung, C., additional, Behrens-Gawlik, V., additional, Khajetoorians, D., additional, Mearini, G., additional, Reischmann, S., additional, Geertz, B., additional, Voit, T., additional, Dreyfus, P., additional, Eschenhagen, T., additional, Carrier, L., additional, Duerr, G. D., additional, Heinemann, J. C., additional, Wenzel, D., additional, Ghanem, A., additional, Alferink, J. C., additional, Zimmer, A., additional, Lutz, B., additional, Welz, A., additional, Fleischmann, B. K., additional, Dewald, O., additional, Sbroggio', M., additional, Bertero, A., additional, Giuliano, L., additional, Brancaccio, M., additional, Tarone, G., additional, Meiser, M., additional, Kohlhaas, M., additional, Chen, Y., additional, Csordas, G., additional, Dorn, G., additional, Maack, C., additional, Stapel, B., additional, Hoch, M., additional, Haghikia, A., additional, Fischer, P., additional, Hilfiker-Kleiner, D., additional, Schroen, B., additional, Corsten, M., additional, Verhesen, W., additional, De Windt, L., additional, Zacchigna, S., additional, Thum, T., additional, Carmeliet, P., additional, Papageorgiou, A., additional, Heymans, S., additional, Lunde, I. G., additional, Finsen, A. V., additional, Florholmen, G., additional, Skrbic, B., additional, Kvaloy, H., additional, Jarstadmarken, H. O., additional, Sjaastad, I., additional, Tonnessen, T., additional, Carlson, C. R., additional, Christensen, G., additional, Paavola, J., additional, Schliffke, S., additional, Rossetti, S., additional, Kuo, I., additional, Yuan, S., additional, Sun, Z., additional, Harris, P., additional, Torres, V., additional, Ehrlich, B., additional, Robinson, P., additional, Adams, K., additional, Zhang, Y.-H., additional, Casadei, B., additional, Watkins, H., additional, Redwood, C., additional, Seneviratne, A. N., additional, Cole, J. E., additional, Goddard, M. E., additional, Mohri, Z., additional, Cross, A. J., additional, Krams, R., additional, Monaco, C., additional, Everaert, B. R., additional, Van Laere, S. J., additional, Hoymans, V. Y., additional, Timmermans, J. P., additional, and Vrints, C. J., additional

Published
2012
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41. Characterisation of corona-generated ions used in a Neutral cluster and Air Ion Spectrometer (NAIS)

Author

Manninen, H. E., primary, Franchin, A., additional, Schobesberger, S., additional, Hirsikko, A., additional, Hakala, J., additional, Skromulis, A., additional, Kangasluoma, J., additional, Ehn, M., additional, Junninen, H., additional, Mirme, A., additional, Mirme, S., additional, Sipilä, M., additional, Petäjä, T., additional, Worsnop, D. R., additional, and Kulmala, M., additional

Published
2011
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42. Intercomparison of air ion spectrometers: an evaluation of results in varying conditions

Author

Gagné, S., primary, Lehtipalo, K., additional, Manninen, H. E., additional, Nieminen, T., additional, Schobesberger, S., additional, Franchin, A., additional, Yli-Juuti, T., additional, Boulon, J., additional, Sonntag, A., additional, Mirme, S., additional, Mirme, A., additional, Hõrrak, U., additional, Petäjä, T., additional, Asmi, E., additional, and Kulmala, M., additional

Published
2011
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43. Intercomparison of air ion spectrometers: a basis for data interpretation

Author

Gagné, S., primary, Lehtipalo, K., additional, Manninen, H. E., additional, Nieminen, T., additional, Schobesberger, S., additional, Franchin, A., additional, Yli-Juuti, T., additional, Boulon, J., additional, Sonntag, A., additional, Mirme, S., additional, Mirme, A., additional, Hõrrak, U., additional, Petäjä, T., additional, Asmi, E., additional, and Kulmala, M., additional

Published
2011
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46. Hygroscopicity of nanoparticles produced from homogeneous nucleation in the CLOUD experiments.

Author

J. Kim, Ahlm, L., Yli-Juuti, T., Lawler, M., Keskinen, H., Tröstl, J., Schobesberger, S., Duplissy, J., Amorim, A., Bianchi, F., Donahue, N. M., Flagan, R. C., Hakala, J., Heinritzi, M., Jokinen, T., Kürten, A., Laaksonen, A., Lehtipalo, K., Miettinen, P., and Petäjä, T.

Abstract

Sulfuric acid, amines and oxidized organics have been found to be important compounds in the nucleation and initial growth of atmospheric particles. Because of the challenges involved in determining the chemical composition of objects with very small mass, however, the properties of the freshly nucleated particles and the detailed pathways of their formation processes are still not clear. In this study, we focus on a challenging size range, i.e., particles that have grown to diameters of 10 and 15 nm following nucleation, and measure their water uptake. Water uptake is useful information for indirectly obtaining chemical composition of aerosol particles. We use a nanometer-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) at subsaturated conditions (ca. 90% relative humidity at 293 K) to measure the hygroscopicity of particles during the seventh Cosmics Leaving OUtdoor Droplets (CLOUD7) campaign performed at CERN in 2012. In CLOUD7, the hygroscopicity of nucleated nanoparticles was measured in the presence of sulfuric acid, sulfuric acid-dimethylamine, and sulfuric acid-organics derived from pinene oxidation. The hygroscopicity parameter κ decreased with increasing particle size, indicating decreasing acidity of particles. No clear effect of the sulfuric acid concentration on the hygroscopicity of 10 nm particles produced from sulfuric acid and dimethylamine was observed, whereas the hygroscopicity of 15 nm particles sharply decreased with decreasing sulfuric acid concentrations. In particular, when the concentration of sulfuric acid was 5:1×106 molecules cm-3 in the gas phase, and the dimethylamine mixing ratio was 11.8 ppt, the measured of 15 nm particles was 0.31±0.01: close to the value reported for dimethylaminium sulfate (DMAS) (κDMAS ∼ 0:28). Furthermore, the difference in κ between sulfuric acid and sulfuric acid-dimethylamine experiments increased with increasing particle size. The κ values of particles in the presence of sulfuric acid and organics were much smaller than those of particles in the presence of sulfuric acid and dimethylamine. This suggests that the organics produced from α-pinene ozonolysis play a significant role in particle growth even at 10 nm sizes. [ABSTRACT FROM AUTHOR]

Published
2016
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47. Thermodynamics of the formation of sulfuric acid dimers in the binary (H2SO4-H2O) and ternary (H2SO4-H2O-NH3) system.

Author

Kürten, A., Münch, S., Rondo, L., Bianchi, F., Duplissy, J., Jokinen, T., Junninen, H., Sarnela, N., Schobesberger, S., Simon, M., Sipilä, M., Almeida, J., Amorim, A., Dommen, J., Donahue, N. M., Dunne, E. M., Flagan, R. C., Franchin, A., Kirkby, J., and Kupc, A.

Subjects
SULFURIC acid -- Environmental aspects, THERMODYNAMICS, DIMERS, TERNARY system, TROPOSPHERE, ATMOSPHERIC chemistry
Abstract

Sulfuric acid is an important gas influencing atmospheric new particle formation (NPF). Both the binary (H2SO4-H2O) system and the ternary system involving ammonia (H2SO4-H2O-NH3) may be important in the free troposphere. An essential step in the nucleation of aerosol particles from gas-phase precursors is the formation of a dimer, so an understanding of the thermodynamics of dimer formation over a wide range of atmospheric conditions is essential to describe NPF. We have used the CLOUD chamber to conduct nucleation experiments for these systems at temperatures from 208 to 248 K. Neutral monomer and dimer concentrations of sulfuric acid were measured using a chemical ionization mass spectrometer (CIMS). From these measurements, dimer evaporation rates in the binary system were derived for temperatures of 208 and 223 K. We compare these results to literature data from a previous study that was conducted at higher temperatures but is in good agreement with the present study. For the ternary system the formation of H2SO4 qNH3 is very likely an essential step in the formation of sulfuric acid dimers, which were measured at 210, 223, and 248 K. We estimate the thermodynamic properties (dH and dS) of the H2SO4 qNH3 cluster using a simple heuristic model and the measured data. Furthermore, we report the first measurements of large neutral sulfuric acid clusters containing as many as 10 sulfuric acid molecules for the binary system using chemical ionization-atmospheric pressure interface time-of-flight (CI-APi-TOF) mass spectrometry. [ABSTRACT FROM AUTHOR]

Published
2015
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48. Hygroscopicity of nanoparticles produced from homogeneous nucleation in the CLOUD experiments.

Author

Kim, J., Ahlm, L., Yli-Juuti, T., Lawler, M., Keskinen, H., Tröstl, J., Schobesberger, S., Duplissy, J., Amorim, A., Bianchi, F., Donahue, N. M., Flagan, R. C., Hakala, J., Heinritzi, M., Jokinen, T., Kürten, A., Laaksonen, A., Lehtipalo, K., Miettinen, P., and Petäjä, T.

Abstract

Sulfuric acid, amines and oxidized organics have been found to be important compounds in the nucleation and initial growth of atmospheric particles. Because of the challenges involved in determining the chemical composition of objects with very small mass, however, the properties of the freshly nucleated particles and the detailed pathways of their formation processes are still not clear. In this study, we focus on a challenging size range, i.e. particles that have grown to diameters of 10 and 15nm following nucleation, and measure their water uptake. Water uptake constrains their chemical composition. We use a nanometer-hygroscopicity tandem differential mobility analyzer (nano-HTDMA) at subsaturated conditions (ca. 90% relative humidity at 293 K) to measure the hygroscopicity of particles during the seventh Cosmics Leaving OUtdoor Droplets (CLOUD7) experiments performed at CERN in 2012. In CLOUD7, the hygroscopicity of nucleated nanoparticles was measured in the presence of sulfuric acid, sulfuric acid-dimethylamine, and sulfuric acid-organics derived from α-pinene oxidation. The hygroscopicity parameter K decreased with increasing particle size indicating decreasing acidity of particles. No clear effect of the sulfuric acid monomer concentrations on the hygroscopicities of 10 nm particles produced from sulfuric acid and dimethylamine was observed, whereas the hygroscopicity of 15nm particles sharply decreased with decreasing sulfuric acid monomer concentrations. In particular, when the concentrations of sulfuric acid was 5.1 x 106 molecules cm-3 in the gas phase, and the dimethylamine mixing ratio was 11.8 ppt, the measured K of 15nm particles was 0.31 ±0.01 close to the value reported for dimethylamine sulfate (DMAS) (KDMAS28). Furthermore, the difference in K between sulfuric acid and sulfuric acid-dimethylamine experiments increased with increasing particle size. The K values of particles in the presence of sulfuric acid and organics were much smaller than those of particles in the presence of sulfuric acid and dimethylamine. This suggests that the organics produced from α-pinene ozonolysis play a significant role in particle growth already at 10 nm sizes. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Experimental investigation of ion-ion recombination at atmospheric conditions.

Author

Franchin, A., Ehrhart, S., Leppä, J., Nieminen, T., Gagné, S., Schobesberger, S., Wimmer, D., Duplissy, J., Riccobono, F., Dunne, E., Rondo, L., Downard, A., Bianchi, F., Kupc, A., Tsagkogeorgas, G., Lehtipalo, K., Manninen, H. E., Almeida, J., Amorim, A., and Wagner, P. E.

Abstract

We present the results of laboratory measurements of the ion-ion recombination coeffcient at different temperatures, relative humidities and concentrations of ozone and sulfur dioxide. The experiments were carried out using the Cosmics Leaving OUtdoor 5 Droplets (CLOUD) chamber at CERN, the walls of which are made of conductive material, making it possible to measure small ions. We produced ions in the chamber using a 3.5GeVc-1 beam of positively-charged pions (π+) from the CERN Proton Synchrotron (PS) and with galactic cosmic rays, when the PS was switched off. The range of the ion production rate varied from 2 to 100 cm-3 s-1, covering the typical range of 10 ionization throughout the troposphere. The temperature ranged from -55 to 20 °C, the relative humidity from 0 to 70 %, the SO2 concentration from 0 to 40 ppb, and the ozone concentration from 200 to 700 ppb. At 20 °C and 40% RH, the retrieved ion-ion recombination coeffcient was (2.3±0.7) ×10-6 cm3 s-1. We observed no dependency of the ion-ion recombination coeffcient on ozone concentration and a weak variation with 15 sulfur dioxide concentration. However, we found a strong dependency of the ion-ion recombination coeffcient on temperature. We compared our results with three different models and found an overall agreement for temperatures above 0 °C, but a disagreement at lower temperatures. We observed a strong dependency of the recombination coeffcient on relative humidity, which has not been reported previously. [ABSTRACT FROM AUTHOR]

Published
2015
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50. Elemental composition and clustering of α-pinene oxidation products for different oxidation conditions.

Author

Praplan, A. P., Schobesberger, S., Bianchi, F., Rissanen, M. P., Ehn, M., Jokinen, T., Junninen, H., Adamov, A., Amorim, A., Dommen, J., Duplissy, J., Hakala, J., Hansel, A., Heinritzi, M., Kangasluoma, J., Kirkby, J., Krapf, M., Kürten, A., Lehtipalo, K., and Riccobono, F.

Abstract

This study presents the difference between oxidised organic compounds formed by α-pinene ozonolysis and hydroxyl radical (OH) oxidation in the CLOUD environmental chamber. The results from three Atmospheric Pressure interface Time-Of-Flight (APi-TOF) mass spectrometers measuring simultaneously the composition of naturally charged, as well as neutral species (via chemical ionisation with nitrate) are discussed. Natural chemical ionisation takes place in the CLOUD chamber and organic oxidised compounds form clusters with nitrate, bisulphate, bisulphate/sulphuric acid clusters, ammonium, and dimethylaminium, or get protonated. This process is selective towards various oxidised organic compounds, so that in order to get a comprehensive picture of the elemental composition of oxidation products, several instruments must be used. A comparison between oxidation products containing 10 and 20 carbon atoms is presented. Oxidation products from ozonolysis showed a higher oxidation state than the ones from OH oxidation. Also, highly oxidised organic compounds are shown to be formed in the early stages of the oxidation, for low α-pinene levels. [ABSTRACT FROM AUTHOR]

Published
2014
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