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303 results on '"Schock, Helena"'

2. Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes : A collaborative re-analysis from the Ovarian Cancer Cohort Consortium

Author

Ose, Jennifer, Schock, Helena, Poole, Elizabeth M., Lehtinen, Matti, Visvanathan, Kala, Helzlsouer, Kathy, Buring, Julie E., Lee, I-Min, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Trichopoulou, Antonia, Mattiello, Amalia, Onland-Moret, N. Charlotte, Weiderpass, Elisabete, Sánchez, María-José, Idahl, Annika, Travis, Ruth C., Rinaldi, Sabina, Merritt, Melissa A., Wentzensen, Nicolas, Tworoger, Shelley S., Kaaks, Rudolf, and Fortner, Renée T.

Published
2017

3. Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

Author

Jung, Seungyoun, Allen, Naomi, Arslan, Alan A., Baglietto, Laura, Brinton, Louise A., Egleston, Brian L., Falk, Roni, Fortner, Renée T., Helzlsouer, Kathy J., Idahl, Annika, Kaaks, Rudolph, Lundin, Eva, Merritt, Melissa, Onland-Moret, Charlotte, Rinaldi, Sabina, Sánchez, María-José, Sieri, Sabina, Schock, Helena, Shu, Xiao-Ou, Sluss, Patrick M., Staats, Paul N., Travis, Ruth C., Tjønneland, Anne, Trichopoulou, Antonia, Tworoger, Shelley, Visvanathan, Kala, Krogh, Vittorio, Weiderpass, Elisabete, Zeleniuch-Jacquotte, Anne, Zheng, Wei, and Dorgan, Joanne F.

Published
2017
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4. Data from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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5. Supplementary Tables 1-6 from Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort

Author

Sarink, Danja, primary, Schock, Helena, primary, Johnson, Theron, primary, Overvad, Kim, primary, Holm, Marianne, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, His, Mathilde, primary, Kvaskoff, Marina, primary, Boeing, Heiner, primary, Lagiou, Pagona, primary, Papatesta, Eleni-Maria, primary, Trichopoulou, Antonia, primary, Palli, Domenico, primary, Pala, Valeria, primary, Mattiello, Amalia, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Bueno-de-Mesquita, H.B(as)., primary, van Gils, Carla H., primary, Peeters, Petra H., primary, Weiderpass, Elisabete, primary, Agudo, Antonio, primary, Sánchez, Maria-José, primary, Chirlaque, Maria-Dolores, primary, Ardanaz, Eva, primary, Amiano, Pilar, primary, Khaw, Kay Tee, primary, Travis, Ruth, primary, Dossus, Laure, primary, Gunter, Mark, primary, Rinaldi, Sabina, primary, Merritt, Melissa, primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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6. Evaluation of added discriminatory ability from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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7. Data from Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort

Author

Fortner, Renée T., primary, Schock, Helena, primary, Kaaks, Rudolf, primary, Lehtinen, Matti, primary, Pukkala, Eero, primary, Lakso, Hans-Åke, primary, Tanner, Minna, primary, Kallio, Raija, primary, Joensuu, Heikki, primary, Korpela, Jaana, primary, Toriola, Adetunji T., primary, Hallmans, Göran, primary, Grankvist, Kjell, primary, Zeleniuch-Jacquotte, Anne, primary, Toniolo, Paolo, primary, Lundin, Eva, primary, and Surcel, Heljä-Marja, primary

Published
2023
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8. Spearman coefficients of correlation from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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9. Supplemental tables 1 and 2 from Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

Author

Ose, Jennifer, primary, Schock, Helena, primary, Tjønneland, Anne, primary, Hansen, Louise, primary, Overvad, Kim, primary, Dossus, Laure, primary, Clavel-Chapelon, Françoise, primary, Baglietto, Laura, primary, Boeing, Heiner, primary, Trichopolou, Antonia, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Masala, Giovanna, primary, Tagliabue, Giovanna, primary, Tumino, Rosario, primary, Sacerdote, Carlotta, primary, Mattiello, Amalia, primary, Bueno-de-Mesquita, H. B(as)., primary, Peeters, Petra H. M., primary, Onland-Moret, N. Charlotte, primary, Weiderpass, Elisabete, primary, Gram, Inger T., primary, Sánchez, Soledad, primary, Obon-Santacana, Mireia, primary, Sànchez-Pérez, Maria-José, primary, Larrañaga, Nerea, primary, Castaño, José María Huerta, primary, Ardanaz, Eva, primary, Brändstedt, Jenny, primary, Lundin, Eva, primary, Idahl, Annika, primary, Travis, Ruth C., primary, Khaw, Kay-Tee, primary, Rinaldi, Sabina, primary, Romieu, Isabelle, primary, Merritt, Melissa A., primary, Gunter, Marc J., primary, Riboli, Elio, primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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10. Supplementary Tables S1-S5, Figure S1 from Androgens Are Differentially Associated with Ovarian Cancer Subtypes in the Ovarian Cancer Cohort Consortium

Author

Ose, Jennifer, primary, Poole, Elizabeth M., primary, Schock, Helena, primary, Lehtinen, Matti, primary, Arslan, Alan A., primary, Zeleniuch-Jacquotte, Anne, primary, Visvanathan, Kala, primary, Helzlsouer, Kathy, primary, Buring, Julie E., primary, Lee, I-Min, primary, Tjønneland, Anne, primary, Dossus, Laure, primary, Trichopoulou, Antonia, primary, Masala, Giovanna, primary, Onland-Moret, N. Charlotte, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Idahl, Annika, primary, Travis, Ruth C., primary, Rinaldi, Sabina, primary, Merritt, Melissa A., primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Tworoger, Shelley S., primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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11. Supplemental Table 1 from Human Chorionic Gonadotropin Does Not Correlate with Risk for Maternal Breast Cancer: Results from the Finnish Maternity Cohort

Author

Fortner, Renée T., primary, Schock, Helena, primary, Kaaks, Rudolf, primary, Lehtinen, Matti, primary, Pukkala, Eero, primary, Lakso, Hans-Åke, primary, Tanner, Minna, primary, Kallio, Raija, primary, Joensuu, Heikki, primary, Korpela, Jaana, primary, Toriola, Adetunji T., primary, Hallmans, Göran, primary, Grankvist, Kjell, primary, Zeleniuch-Jacquotte, Anne, primary, Toniolo, Paolo, primary, Lundin, Eva, primary, and Surcel, Heljä-Marja, primary

Published
2023
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12. Data from Androgens Are Differentially Associated with Ovarian Cancer Subtypes in the Ovarian Cancer Cohort Consortium

Author

Ose, Jennifer, primary, Poole, Elizabeth M., primary, Schock, Helena, primary, Lehtinen, Matti, primary, Arslan, Alan A., primary, Zeleniuch-Jacquotte, Anne, primary, Visvanathan, Kala, primary, Helzlsouer, Kathy, primary, Buring, Julie E., primary, Lee, I-Min, primary, Tjønneland, Anne, primary, Dossus, Laure, primary, Trichopoulou, Antonia, primary, Masala, Giovanna, primary, Onland-Moret, N. Charlotte, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Idahl, Annika, primary, Travis, Ruth C., primary, Rinaldi, Sabina, primary, Merritt, Melissa A., primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Tworoger, Shelley S., primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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13. Supplementary Methods and Material from A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure–Cancer Associations

Author

Ertaylan, Gökhan, primary, Le Cornet, Charlotte, primary, van Roekel, Eline H., primary, Jung, Audrey Y., primary, Bours, Martijn J.L., primary, Damms-Machado, Antje, primary, van den Brandt, Piet A., primary, Schock, Helena, primary, de Kok, Theo M., primary, Theys, Jan, primary, Arts, Ilja C.W., primary, Kaaks, Rudolf, primary, Weijenberg, Matty P., primary, and Fortner, Renée Turzanski, primary

Published
2023
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14. ROC curves and C-statistics by tumor stage from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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15. C-statistics by tumor histology from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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16. Case characteristics from A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L., primary, Schock, Helena, primary, Fortner, Renée T., primary, Hüsing, Anika, primary, Fichorova, Raina N., primary, Yamamoto, Hidemi S., primary, Vitonis, Allison F., primary, Johnson, Theron, primary, Overvad, Kim, primary, Tjønneland, Anne, primary, Boutron-Ruault, Marie-Christine, primary, Mesrine, Sylvie, primary, Severi, Gianluca, primary, Dossus, Laure, primary, Rinaldi, Sabina, primary, Boeing, Heiner, primary, Benetou, Vassiliki, primary, Lagiou, Pagona, primary, Trichopoulou, Antonia, primary, Krogh, Vittorio, primary, Kuhn, Elisabetta, primary, Panico, Salvatore, primary, Bueno-de-Mesquita, H. Bas, primary, Onland-Moret, N. Charlotte, primary, Peeters, Petra H., primary, Gram, Inger Torhild, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Sanchez, Maria-Jose, primary, Ardanaz, Eva, primary, Etxezarreta, Nerea, primary, Navarro, Carmen, primary, Idahl, Annika, primary, Lundin, Eva, primary, Jirström, Karin, primary, Manjer, Jonas, primary, Wareham, Nicholas J., primary, Khaw, Kay-Tee, primary, Byrne, Karl Smith, primary, Travis, Ruth C., primary, Gunter, Marc J., primary, Merritt, Melissa A., primary, Riboli, Elio, primary, Cramer, Daniel W., primary, and Kaaks, Rudolf, primary

Published
2023
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17. Data from A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure–Cancer Associations

Author

Ertaylan, Gökhan, primary, Le Cornet, Charlotte, primary, van Roekel, Eline H., primary, Jung, Audrey Y., primary, Bours, Martijn J.L., primary, Damms-Machado, Antje, primary, van den Brandt, Piet A., primary, Schock, Helena, primary, de Kok, Theo M., primary, Theys, Jan, primary, Arts, Ilja C.W., primary, Kaaks, Rudolf, primary, Weijenberg, Matty P., primary, and Fortner, Renée Turzanski, primary

Published
2023
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18. Supplementary Methods from Androgens Are Differentially Associated with Ovarian Cancer Subtypes in the Ovarian Cancer Cohort Consortium

Author

Ose, Jennifer, primary, Poole, Elizabeth M., primary, Schock, Helena, primary, Lehtinen, Matti, primary, Arslan, Alan A., primary, Zeleniuch-Jacquotte, Anne, primary, Visvanathan, Kala, primary, Helzlsouer, Kathy, primary, Buring, Julie E., primary, Lee, I-Min, primary, Tjønneland, Anne, primary, Dossus, Laure, primary, Trichopoulou, Antonia, primary, Masala, Giovanna, primary, Onland-Moret, N. Charlotte, primary, Weiderpass, Elisabete, primary, Duell, Eric J., primary, Idahl, Annika, primary, Travis, Ruth C., primary, Rinaldi, Sabina, primary, Merritt, Melissa A., primary, Trabert, Britton, primary, Wentzensen, Nicolas, primary, Tworoger, Shelley S., primary, Kaaks, Rudolf, primary, and Fortner, Renée T., primary

Published
2023
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19. Supplemental Table from Early Pregnancy Sex Steroids and Maternal Breast Cancer: A Nested Case–Control Study

Author

Fortner, Renée T., primary, Schock, Helena, primary, Kaaks, Rudolf, primary, Lehtinen, Matti, primary, Pukkala, Eero, primary, Lakso, Hans-Åke, primary, Tanner, Minna, primary, Kallio, Raija, primary, Joensuu, Heikki, primary, Grankvist, Kjell, primary, Zeleniuch-Jacquotte, Anne, primary, Toniolo, Paolo, primary, Lundin, Eva, primary, and Surcel, Helja-Marja, primary

Published
2023
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20. Data from Early Pregnancy Sex Steroids and Maternal Breast Cancer: A Nested Case–Control Study

Author

Fortner, Renée T., primary, Schock, Helena, primary, Kaaks, Rudolf, primary, Lehtinen, Matti, primary, Pukkala, Eero, primary, Lakso, Hans-Åke, primary, Tanner, Minna, primary, Kallio, Raija, primary, Joensuu, Heikki, primary, Grankvist, Kjell, primary, Zeleniuch-Jacquotte, Anne, primary, Toniolo, Paolo, primary, Lundin, Eva, primary, and Surcel, Helja-Marja, primary

Published
2023
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21. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Hüsing, Anika, Dossus, Laure, Ferrari, Pietro, Tjønneland, Anne, Hansen, Louise, Fagherazzi, Guy, Baglietto, Laura, Schock, Helena, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Bamia, Christina, Katsoulis, Michalis, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Weiderpass, Elisabete, Gram, Inger T., Ardanaz, Eva, Obón-Santacana, Mireia, Navarro, Carmen, Sánchez-Cantalejo, Emilio, Etxezarreta, Nerea, Allen, Naomi E., Khaw, Kay Tee, Wareham, Nick, Rinaldi, Sabina, Romieu, Isabelle, Merritt, Melissa A., Gunter, Marc, Riboli, Elio, and Kaaks, Rudolf

Published
2016

22. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort

Author

Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, van Gils, Carla H., Peeters, Petra H. M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.

Published
2018
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23. Anti‐Müllerian hormone and risk of ovarian cancer in nine cohorts

Author

Jung, Seungyoun, Allen, Naomi, Arslan, Alan A., Baglietto, Laura, Barricarte, Aurelio, Brinton, Louise A., Egleston, Brian L., Falk, Roni T., Fortner, Renée T., Helzlsouer, Kathy J., Gao, Yutang, Idahl, Annika, Kaaks, Rudolph, Krogh, Vittorio, Merritt, Melissa A., Lundin, Eva, Onland‐Moret, N. Charlotte, Rinaldi, Sabina, Schock, Helena, Shu, Xiao‐Ou, Sluss, Patrick M., Staats, Paul N., Sacerdote, Carlotta, Travis, Ruth C., Tjønneland, Anne, Trichopoulou, Antonia, Tworoger, Shelley S., Visvanathan, Kala, Weiderpass, Elisabete, Zeleniuch‐Jacquotte, Anne, and Dorgan, Joanne F.

Published
2018
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27. Reproductive and hormone-related risk factors for epithelial ovarian cancer by histologic pathways, invasiveness and histologic subtypes: Results from the EPIC cohort

Author

Fortner, Renée T., Ose, Jennifer, Merritt, Melissa A., Schock, Helena, Tjnneland, Anne, Hansen, Louise, Overvad, Kim, Dossus, Laure, Clavel-Chapelon, Françoise, Baglietto, Laura, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Lagiou, Pagona, Agnoli, Claudia, Mattiello, Amalia, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Peeters, Petra H., Weiderpass, Elisabete, Gram, Inger Torhild, Duell, Eric J, Larrañaga, Nerea, Ardanaz, Eva, Sánchez, María-José, Chirlaque, M-D, Brändstedt, Jenny, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Wareham, Nick, Travis, Ruth C., Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J., Riboli, Elio, and Kaaks, Rudolf

Published
2015
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29. Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition

Author

Ose, Jennifer, Fortner, Renée T., Rinaldi, Sabina, Schock, Helena, Overvad, Kim, Tjonneland, Anne, Hansen, Louise, Dossus, Laure, Fournier, Agnes, Baglietto, Laura, Romieu, Isabelle, Kuhn, Elisabetta, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Masala, Giovanna, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Quiros, Jose Ramon, Obón-Santacana, Mireia, Larrañaga, Nerea, Chirlaque, María-Dolores, Sánchez, María-José, Barricarte, Aurelio, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Onland-Moret, Charlotte N., Brändstedt, Jenny, Lundin, Eva, Idahl, Annika, Weiderpass, Elisabete, Gram, Inger T., Lund, Eiliv, Kaw, Kay-Tee, Travis, Ruth C., Merritt, Melissa A., Gunther, Marc J., Riboli, Elio, and Kaaks, Rudolf

Published
2015
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31. Premenopausal serum sex hormone levels in relation to breast cancer risk, overall and by hormone receptor status—Results from the EPIC cohort

Author

Kaaks, Rudolf, Tikk, Kaja, Sookthai, Disorn, Schock, Helena, Johnson, Theron, Tjnneland, Anne, Olsen, Anja, Overvad, Kim, Clavel-Chapelon, Françoise, Dossus, Laure, Baglietto, Laura, Rinaldi, Sabina, Chajes, Veronique, Romieu, Isabelle, Boeing, Heiner, Schütze, Madlen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Ricceri, Fulvio, Mattiello, Amalia, Buckland, Genevieve, Ramón Quirós, Jose, Sánchez, María-José, Amiano, Pilar, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Bas Bueno-de-Mesquita, H., van Gils, Carla H., Peeters, Petra H., Andersson, Anne, Sund, Malin, Weiderpass, Elisabete, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Merritt, Melissa A., Gunter, Marc J., Riboli, Elio, and Lukanova, Annekatrin

Published
2014
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32. Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?

Author

Lukanova, Annekatrin, Becker, Susen, Hüsing, Anika, Schock, Helena, Fedirko, Veronika, Trepo, Elisabeth, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Benetou, Vassiliki, Trichopoulos, Dimitrios, Nöthlings, Ute, Tjnneland, Anne, Overvad, Kim, Dossus, Laure, Teucher, Birgit, Boeing, Heiner, Aleksandrova, Krasimira, Palli, Domenico, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas H., Siersema, Peter D., Peeters, Petra H.M., Quiros, Jose Ramon, Duell, Eric J., Molina-Montes, Esther, Chirlaque, Maria-Dolores, Gurrea, Aurelio Barricarte, Dorronsoro, Miren, Lindkvist, Björn, Johansen, Dorthe, Werner, Mårten, Sund, Malin, Khaw, Kay-Tee, Wareham, Nick, Key, Timothy J., Travis, Ruth C., Rinaldi, Sabina, Romieu, Isabelle, Gunter, Marc J., Riboli, Elio, Jenab, Mazda, and Kaaks, Rudolf

Published
2014
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35. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort

Author

Fortner, Renée T, Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F, Johnson, Theron S, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Quirós, J Ramón, Duell, Eric J, Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Travis, Ruth C, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A, Riboli, Elio, Terry, Kathryn L, Cramer, Daniel W, and Kaaks, Rudolf

Subjects
Adult, anti-CA125 antibodies, endocrine system diseases, autoantibodies, MUC16, BIOMARKERS, DIAGNOSIS, Sensitivity and Specificity, Article, Cohort Studies, CA125, Biomarkers, Tumor, Journal Article, Humans, Oncology & Carcinogenesis, TUMOR-ASSOCIATED ANTIGENS, Early Detection of Cancer, Aged, Autoantibodies, Ovarian Neoplasms, Science & Technology, Membrane Proteins, Middle Aged, female genital diseases and pregnancy complications, ovarian cancer, Oncology, ROC Curve, Area Under Curve, CA-125 Antigen, Case-Control Studies, IMMUNE-COMPLEXES, Female, early detection markers, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis, LUNG
Abstract

CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to 4 matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated towards the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed

Published
2018
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36. Anti-Mullerian hormone and risk of ovarian cancer in nine cohorts

Author

Jung, Seungyoun Allen, Naomi Arslan, Alan A. Baglietto, Laura Barricarte, Aurelio Brinton, Louise A. Egleston, Brian L. Falk, Roni T. Fortner, Renee T. Helzlsouer, Kathy J. and Gao, Yutang Idahl, Annika Kaaks, Rudolph Krogh, Vittorio and Merritt, Melissa A. Lundin, Eva Onland-Moret, N. Charlotte and Rinaldi, Sabina Schock, Helena Shu, Xiao-Ou Sluss, Patrick M. Staats, Paul N. Sacerdote, Carlotta Travis, Ruth C. and Tjonneland, Anne Trichopoulou, Antonia Tworoger, Shelley S. and Visvanathan, Kala Weiderpass, Elisabete Zeleniuch-Jacquotte, Anne Dorgan, Joanne F.

Subjects
endocrine system, endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Animal and experimental data suggest that anti-Mullerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable-adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59-1.67) (P-trend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all P-heterogeneity: >= 0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all P-heterogeneity: >= 0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer.

Published
2018

37. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels : Results from the EPIC cohort

Author

Fortner, Renée T., Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F., Johnson, Theron S., Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Travis, Ruth C., Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L., Cramer, Daniel W., Kaaks, Rudolf, Fortner, Renée T., Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F., Johnson, Theron S., Fichorova, Raina N., Fashemi, Titilayo, Yamamoto, Hidemi S., Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N. Charlotte, Peeters, Petra H., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Quirós, J. Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay-Tee, Travis, Ruth C., Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L., Cramer, Daniel W., and Kaaks, Rudolf

Abstract

CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; p(het)=0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection. What's new? Although CA125, a mucin produced in epithelial cells, is a known marker for ovarian cancer, complementary biomarkers are necessary for reliable early cancer detection. Here, the authors examined aut

Published
2018
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38. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels : Results from the EPIC cohort

Author

Turzanski-Fortner, Renée, Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F, Johnson, Theron S, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay Tee, Travis, Ruth C., Gunter, Marc J., Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L, Cramer, Daniel W., Kaaks, Rudolf, Turzanski-Fortner, Renée, Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F, Johnson, Theron S, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay Tee, Travis, Ruth C., Gunter, Marc J., Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L, Cramer, Daniel W., and Kaaks, Rudolf

Published
2018

39. Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: Results from the EPIC cohort

Author

Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, Fortner, Renée T., Epi Methoden Team 4, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Schock, Helena, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjønneland, Anne, Arveux, Patrick, Fournier, Agnès, Kvaskoff, Marina, Boeing, Heiner, Karakatsani, Anna, Trichopoulou, Antonia, La Vecchia, Carlo, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Van Gils, Carla H., Peeters, Petra H.M., Weiderpass, Elisabete, Agudo, Antonio, Rodríguez-Barranco, Miguel, Huerta, José María, Ardanaz, Eva, Gil, Leire, Kaw, Kay Tee, Schmidt, Julie A., Dossus, Laure, His, Mathilde, Aune, Dagfinn, Riboli, Elio, Kaaks, Rudolf, and Fortner, Renée T.

Published
2018

40. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort

Author

Cardiovasculaire Epi Team 3, Brain, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Turzanski-Fortner, Renée, Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F, Johnson, Theron S, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay Tee, Travis, Ruth C., Gunter, Marc J., Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L, Cramer, Daniel W., Kaaks, Rudolf, Cardiovasculaire Epi Team 3, Brain, Cancer, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team 1, Turzanski-Fortner, Renée, Schock, Helena, Le Cornet, Charlotte, Hüsing, Anika, Vitonis, Allison F, Johnson, Theron S, Fichorova, Raina N, Fashemi, Titilayo, Yamamoto, Hidemi S, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Boutron-Ruault, Marie Christine, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Papatesta, Eleni-Maria, La Vecchia, Carlo, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Onland-Moret, N Charlotte, Peeters, Petra H, Bueno-de-Mesquita, H B As, Weiderpass, Elisabete, Quirós, José Ramón, Duell, Eric J., Sánchez, Maria-Jose, Navarro, Carmen, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Jirström, Karin, Idahl, Annika, Lundin, Eva, Khaw, Kay Tee, Travis, Ruth C., Gunter, Marc J., Johansson, Mattias, Dossus, Laure, Merritt, Melissa A., Riboli, Elio, Terry, Kathryn L, Cramer, Daniel W., and Kaaks, Rudolf

Published
2018

41. Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

Author

Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Kanker, Jung, Seungyoun, Allen, Naomi E., Arslan, Alan A, Baglietto, Laura, Barricarte, Aurelio, Brinton, Louise A, Egleston, Brian L., Falk, Roni T, Turzanski-Fortner, Renée, Helzlsouer, Kathy J, Gao, Yutang, Idahl, Annika, Kaaks, Rudolph, Krogh, Vittorio, Merritt, Melissa A., Lundin, Eva, Onland-Moret, N Charlotte, Rinaldi, Sabina, Schock, Helena, Shu, Xiao Ou, Sluss, Patrick M., Staats, Paul N., Sacerdote, Carlotta, Travis, Ruth C., Tjønneland, Anne, Trichopoulou, Antonia, Tworoger, Shelley S., Visvanathan, Kala, Weiderpass, Elisabete, Zeleniuch-Jacquotte, Anne, Dorgan, Joanne F., Cardiovasculaire Epi Team 3, Cancer, JC onderzoeksprogramma Kanker, Jung, Seungyoun, Allen, Naomi E., Arslan, Alan A, Baglietto, Laura, Barricarte, Aurelio, Brinton, Louise A, Egleston, Brian L., Falk, Roni T, Turzanski-Fortner, Renée, Helzlsouer, Kathy J, Gao, Yutang, Idahl, Annika, Kaaks, Rudolph, Krogh, Vittorio, Merritt, Melissa A., Lundin, Eva, Onland-Moret, N Charlotte, Rinaldi, Sabina, Schock, Helena, Shu, Xiao Ou, Sluss, Patrick M., Staats, Paul N., Sacerdote, Carlotta, Travis, Ruth C., Tjønneland, Anne, Trichopoulou, Antonia, Tworoger, Shelley S., Visvanathan, Kala, Weiderpass, Elisabete, Zeleniuch-Jacquotte, Anne, and Dorgan, Joanne F.

Published
2018

42. Additional file 1: Table S1. of Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

Author

Fortner, Renée, Vitonis, Allison, Schock, Helena, Hüsing, Anika, Johnson, Theron, Fichorova, Raina, Titilayo Fashemi, Yamamoto, Hidemi, Tjønneland, Anne, Hansen, Louise, Overvad, Kim, Marie-Christine Boutron-Ruault, Kvaskoff, Marina, Severi, Gianluca, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vassiliki, Vecchia, Carlo La, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Matullo, Giuseppe, Mattiello, Amalia, N. Onland-Moret, Peeters, Petra, Weiderpass, Elisabete, Gram, Inger, Jareid, Mie, J. Quirós, Duell, Eric, Maria-Jose Sánchez, Chirlaque, María, Ardanaz, Eva, Larrañaga, Nerea, Nodin, Björn, Brändstedt, Jenny, Idahl, Annika, Kay-Tee Khaw, Allen, Naomi, Gunter, Marc, Johansson, Mattias, Dossus, Laure, Merritt, Melissa, Riboli, Elio, Cramer, Daniel, Kaaks, Rudolf, and Terry, Kathryn

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Association between epidemiologic characteristics and high CA72.4 by menopausal status at blood collection in healthy women: EPIC. Table S2. Multivariate adjusted association between epidemiologic characteristics and CA125, CA15.3 and HE4 by menopausal status at blood collection in healthy women: EPIC. Table S3. Association between epidemiologic characteristics and CA125, CA15.3, and HE4 by menopausal status at blood collection in women with ovarian cancer: EPIC (DOCX 75 kb)

Published
2017
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43. Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort

Author

Fortner, Renee T. Sarink, Danja Schock, Helena Johnson, Theron Tjonneland, Anne Olsen, Anja Overvad, Kim Affret, Aurelie His, Mathilde Boutron-Ruault, Marie-Christine and Boeing, Heiner Trichopoulou, Antonia Naska, Androniki and Orfanos, Philippos Palli, Domenico Sieri, Sabina Mattiello, Amalia Tumino, Rosario Ricceri, Fulvio Bueno-de-Mesquita, H. Bas Peeters, Petra H. M. Van Gils, Carla H. Weiderpass, Elisabete Lund, Eiliv Quiros, J. Ramon Agudo, Antonio and Sanchez, Maria-Jose Chirlaque, Maria-Dolores Ardanaz, Eva and Dorronsoro, Miren Key, Tim Khaw, Kay-Tee Rinaldi, Sabina and Dossus, Laure Gunter, Marc Merritt, Melissa A. Riboli, Elio and Kaaks, Rudolf

Subjects
musculoskeletal diseases
Abstract

Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer.

Published
2017

44. Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium

Author

Ose, Jennifer Schock, Helena Poole, Elizabeth M. Lehtinen, Matti Visvanathan, Kala Helzlsouer, Kathy Buring, Julie E. and Lee, I-Min Tjonneland, Anne Boutron-Ruault, Marie-Christine and Trichopoulou, Antonia Mattiello, Amalia Onland-Moret, N. Charlotte Weiderpass, Elisabete Sanchez, Maria-Jose Idahl, Annika Travis, Ruth C. Rinaldi, Sabina Merritt, Melissa A. and Wentzensen, Nicolas Tworoger, Shelley S. Kaaks, Rudolf and Fortner, Renee T.

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC. We evaluated IGF-I concentrations and risk of EOC overall and by tumor subtype (defined by histology, grade, stage) in 1,270 cases and 2,907 matched controls. Multivariable conditional logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). Doubling of IGF-I concentration was associated with significantly lower risk of overall EOC [ORlog2 = 0.82; CI 0.72-0.93]. We observed no heterogeneity by tumor characteristics (e.g., histology, p (het) = 0.62), menopausal status at blood collection (p (het) = 0.79), or age at diagnosis (p (het) = 0.60). These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including, considering other members of the IGF-family to better characterize the role of IGF-signaling in the etiology of EOC.

Published
2017

45. A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort

Author

Terry, Kathryn L. Schock, Helena Fortner, Renee T. Huesing, Anika Fichorova, Raina N. Yamamoto, Hidemi S. Vitonis, Allison F. Johnson, Theron Overvad, Kim Tjonneland, Anne and Boutron-Ruault, Marie-Christine Mesrine, Sylvie Severi, Gianluca and Dossus, Laure Rinaldi, Sabina Boeing, Heiner Benetou, Vassiliki Lagiou, Pagona Trichopoulou, Antonia Krogh, Vittorio Kuhn, Elisabetta Panico, Salvatore and Bueno-de-Mesquita, H. Bas Onland-Moret, N. Charlotte Peeters, Petra H. Gram, Inger Torhild Weiderpass, Elisabete Duell, Eric J. Sanchez, Maria-Jose Ardanaz, Eva Etxezarreta, Nerea and Navarro, Carmen Idahl, Annika Lundin, Eva Jirstrom, Karin Manjer, Jonas Wareham, Nicholas J. Khaw, Kay-Tee and Byrne, Karl Smith Travis, Ruth C. Gunter, Marc J. Merritt, Melissa A. Riboli, Elio Cramer, Daniel W. Kaaks, Rudolf

Abstract

Purpose: About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate earlydetection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study. Experimental Design: We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis. Results: We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker. Conclusions: CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases. (C) 2016 AACR.

Published
2016

46. An epidemiological model for prediction of endometrial cancer risk in Europe

Author

Huesing, Anika Dossus, Laure Ferrari, Pietro Tjonneland, Anne Hansen, Louise Fagherazzi, Guy Baglietto, Laura and Schock, Helena Chang-Claude, Jenny Boeing, Heiner Steffen, Annika Trichopoulou, Antonia Bamia, Christina Katsoulis, Michalis Krogh, Vittorio Palli, Domenico Panico, Salvatore and Onland-Moret, N. Charlotte Peeters, Petra H. and Bueno-de-Mesquita, H. Bas Weiderpass, Elisabete Gram, Inger T. and Ardanaz, Eva Obon-Santacana, Mireia Navarro, Carmen and Sanchez-Cantalejo, Emilio Etxezarreta, Nerea Allen, Naomi E. and Khaw, Kay Tee Wareham, Nick Rinaldi, Sabina Romieu, Isabelle and Merritt, Melissa A. Gunter, Marc Riboli, Elio Kaaks, Rudolf

Abstract

Endometrial cancer (EC) is the fourth most frequent cancer in women in Europe, and as its incidence is increasing, prevention strategies gain further pertinence. Risk prediction models can be a useful tool for identifying women likely to benefit from targeted prevention measures. On the basis of data from 201,811 women (mostly aged 30-65 years) including 855 incident EC cases from eight countries in the European Prospective Investigation into Cancer and Nutrition cohort, a model to predict EC was developed. A step-wise model selection process was used to select confirmed predictive epidemiologic risk factors. Piece-wise constant hazard rates in 5-year age-intervals were estimated in a cause-specific competing risks model, five-fold-cross-validation was applied for internal validation. Risk factors included in the risk prediction model were body-mass index (BMI), menopausal status, age at menarche and at menopause, oral contraceptive use, overall and by different BMI categories and overall duration of use, parity, age at first full-term pregnancy, duration of menopausal hormone therapy and smoking status (specific for pre, peri- and post-menopausal women). These variables improved the discriminating capacity to predict risk over 5 years from 71 % for a model based on age alone to 77 % (overall C statistic), and the model was well-calibrated (ratio of expected to observed cases = 0.99). Our model could be used for the identification of women at increased risk of EC in Western Europe. To achieve an EC-risk model with general validity, a large-scale cohort-consortium approach would be needed to assess and adjust for population variation.

Published
2016

47. Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort

Author

Fortner, Renée T., primary, Schock, Helena, additional, Le Cornet, Charlotte, additional, Hüsing, Anika, additional, Vitonis, Allison F., additional, Johnson, Theron S., additional, Fichorova, Raina N., additional, Fashemi, Titilayo, additional, Yamamoto, Hidemi S., additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Boutron-Ruault, Marie-Christine, additional, Kvaskoff, Marina, additional, Severi, Gianluca, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Papatesta, Eleni-Maria, additional, La Vecchia, Carlo, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Onland-Moret, N. Charlotte, additional, Peeters, Petra H., additional, Bueno-de-Mesquita, H. Bas, additional, Weiderpass, Elisabete, additional, Quirós, J. Ramón, additional, Duell, Eric J., additional, Sánchez, Maria-Jose, additional, Navarro, Carmen, additional, Ardanaz, Eva, additional, Larrañaga, Nerea, additional, Nodin, Björn, additional, Jirström, Karin, additional, Idahl, Annika, additional, Lundin, Eva, additional, Khaw, Kay-Tee, additional, Travis, Ruth C., additional, Gunter, Marc, additional, Johansson, Mattias, additional, Dossus, Laure, additional, Merritt, Melissa A., additional, Riboli, Elio, additional, Terry, Kathryn L., additional, Cramer, Daniel W., additional, and Kaaks, Rudolf, additional

Published
2017
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48. A Comparative Study on the WCRF International/University of Bristol Methodology for Systematic Reviews of Mechanisms Underpinning Exposure–Cancer Associations

Author

Ertaylan, Gökhan, primary, Le Cornet, Charlotte, additional, van Roekel, Eline H., additional, Jung, Audrey Y., additional, Bours, Martijn J.L., additional, Damms-Machado, Antje, additional, van den Brandt, Piet A., additional, Schock, Helena, additional, de Kok, Theo M., additional, Theys, Jan, additional, Arts, Ilja C.W., additional, Kaaks, Rudolf, additional, Weijenberg, Matty P., additional, and Fortner, Renée Turzanski, additional

Published
2017
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49. Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts

Author

Jung, Seungyoun, primary, Allen, Naomi, additional, Arslan, Alan A., additional, Baglietto, Laura, additional, Barricarte, Aurelio, additional, Brinton, Louise A., additional, Egleston, Brian L., additional, Falk, Roni T., additional, Fortner, Renée T., additional, Helzlsouer, Kathy J., additional, Gao, Yutang, additional, Idahl, Annika, additional, Kaaks, Rudolph, additional, Krogh, Vittorio, additional, Merritt, Melissa A., additional, Lundin, Eva, additional, Onland-Moret, N. Charlotte, additional, Rinaldi, Sabina, additional, Schock, Helena, additional, Shu, Xiao-Ou, additional, Sluss, Patrick M., additional, Staats, Paul N., additional, Sacerdote, Carlotta, additional, Travis, Ruth C., additional, Tjønneland, Anne, additional, Trichopoulou, Antonia, additional, Tworoger, Shelley S., additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Zeleniuch-Jacquotte, Anne, additional, and Dorgan, Joanne F., additional

Published
2017
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50. Anti-Mullerian hormone and endometrial cancer: a multi-cohort study

Author

Fortner, Renée T, primary, Schock, Helena, additional, Jung, Seungyoun, additional, Allen, Naomi E, additional, Arslan, Alan A, additional, Brinton, Louise A, additional, Egleston, Brian L, additional, Falk, Roni T, additional, Gunter, Marc J, additional, Helzlsouer, Kathy J, additional, Idahl, Annika, additional, Johnson, Theron S, additional, Kaaks, Rudolf, additional, Krogh, Vittorio, additional, Lundin, Eva, additional, Merritt, Melissa A, additional, Navarro, Carmen, additional, Onland-Moret, N Charlotte, additional, Palli, Domenico, additional, Shu, Xiao-Ou, additional, Sluss, Patrick M, additional, Staats, Paul N, additional, Trichopoulou, Antonia, additional, Weiderpass, Elisabete, additional, Zeleniuch-Jacquotte, Anne, additional, Zheng, Wei, additional, and Dorgan, Joanne F, additional

Published
2017
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