27 results on '"Scholing, M"'
Search Results
2. Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022
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de Gier, Brechje, Marchal, Niek, de Beer-Schuurman, Ilse, te Wierik, Margreet, Hooiveld, Mariëtte, de Melker, Hester E., van Sorge, Nina M., Stuart, J. W. T. Cohen, Melles, D. C., van Dijk, K., Alzubaidy, A., Scholing, M., Kuil, S. D., Blaauw, G. J., Altorf-van der Kuil, W., Bierman, S. M., de Greeff, S. C., Groenendijk, S. R., Hertroys, R., Kuijper, E. J., Marchal, N., Monen, J. C. M., Notermans, D. W., Polman, J., van den Reek, W. J., Schneeberger-van der Linden, C., Schoffelen, A. F., Wielders, C. C. H., de Wit, B. J., Zoetigheid, R. E., van den Bijllaardt, W., Kraan, E. M., Haeseker, M. B., da Silva, J. M., de Jong, E., Maraha, B., van Griethuysen, A. J., Wintermans, B. B., van Trijp, M. J. C. A., Wong, M., Muller, A. E., Ott, A., Lokate, M., Bathoorn, E., Sinnige, J., Silvis, W., Renders, N. H., Bakker, L. J., Dorigo-Zetsma, J. W., Waar, K., van der Beek, M. T., Leversteijn-van Hall, M. A., van Mens, S. P., Schaftenaar, E., Nabuurs-Franssen, M. H., Maat, I., Diederen, B. M. W., Bode, L. G. M., Ong, D. S. Y., van Rijn, M., Dinant, S., Pontesilli, O., van Dam, D. W., de Brauwer, E. I. G. B., Bentvelsen, R. G., Buiting, A. G. M., Vlek, A. L. M., de Graaf, M., Troelstra, A., Jansz, A. R., van Meer, M. P. A., de Vries, J., Dos Santos, C. Oliveira, Rümke, Lidewij W., Vestjens, Stefan M. T., Vlaminckx, Bart J. M., Medical Microbiology and Infection Prevention, AII - Infectious diseases, APH - Global Health, APH - Methodology, APH - Quality of Care, Experimental Immunology, AII - Inflammatory diseases, APH - Aging & Later Life, and APH - Health Behaviors & Chronic Diseases
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Adult ,Chickenpox ,Streptococcus pyogenes ,Child, Preschool ,Streptococcal Infections/diagnosis ,COVID-19 ,Humans ,Netherlands/epidemiology ,Child ,Herpes Zoster ,Pandemics - Abstract
In 2022, a sevenfold increase in the number of notifiable invasive Streptococcus pyogenes (iGAS) infections among children aged 0-5 years was observed in the Netherlands compared with pre-COVID-19 pandemic years. Of 42 cases in this age group, seven had preceding or coinciding varicella zoster infections, nine were fatal. This increase is not attributable to a specific emm type. Vigilance for clinical deterioration as iGAS sign is warranted in young children, especially those with varicella zoster infection.
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- 2023
3. The value of postmortem computed tomography as an alternative for autopsy in trauma victims: a systematic review
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Scholing, M., Saltzherr, T. P., Fung Kon Jin, P. H. P., Ponsen, K. J., Reitsma, J. B., Lameris, J. S., and Goslings, J. C.
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- 2009
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4. Clinical Features of Liver Involvement in Adult Patients with Listeriosis. Review of the Literature
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Scholing, M., Schneeberger, P. M., van den Dries, P., and Drenth, J. P. H.
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- 2007
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5. Lack of Discriminating Signs and Symptoms in Clinical Diagnosis of Influenza of Patients Admitted to the Hospital
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v. d. Hoeven, A. M., Scholing, M., Wever, P. C., Fijnheer, R., Hermans, M., and Schneeberger, P. M.
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- 2007
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6. Second MRSA outbreak in a nursing home; role for a super spreader or super sensitive resident
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Gruteke P, Haenen A, Scholing M, van Teunenbroek C, and de Neeling A
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Medicine ,Science - Published
- 2011
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7. Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985–2018
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Birnie, E. (Emma), Savelkoel, J. (Jelmer), Reubsaet, F. (F.), Roelofs, J.J.T.H. (Joris), Soetekouw, R. (Robert), Kolkman, S. (Saskia), Cremers, A.L. (Anne Lia), Grobusch, M.P. (Martin P.), Notermans, D.W. (Daan), Wiersinga, W.J. (W. Joost), Rozemeijer, W. (Wouter), Rijkeboer, A. (Annemieke), Scholing, M. (Maarten), van Dijk, K. (K.), Mascini, E. (Ellen), Van Der Veen, H. (Henk), van den Bijllaardt, W. (Wouter), de Vries, M. (Maaike), Smeets, L.C. (Leonard C.), Ott, A. (Alewijn), van Krimpen, K. (Kees), Herpers, B.L., Watttel-Louis, G.H. (G. Hanke), Waar, K. (Karola), Schwandt, N.L.Q. (Noortje L.Q.), Maat, I. (Ianthe), Dofferhoff, A.S.M. (Anton), Vermeulen, J.N. (Joost N.), Westreenen, M. (Mireille) van, Man, P. (Peter) de, Hofland, R.W. (Regina W.), van Gorp, J. (J.), Thijsen, S.F. (Steven), Velden, L.A. (Lilly Ann) van der, Verduin, C.M. (Cornelis M.), Birnie, E. (Emma), Savelkoel, J. (Jelmer), Reubsaet, F. (F.), Roelofs, J.J.T.H. (Joris), Soetekouw, R. (Robert), Kolkman, S. (Saskia), Cremers, A.L. (Anne Lia), Grobusch, M.P. (Martin P.), Notermans, D.W. (Daan), Wiersinga, W.J. (W. Joost), Rozemeijer, W. (Wouter), Rijkeboer, A. (Annemieke), Scholing, M. (Maarten), van Dijk, K. (K.), Mascini, E. (Ellen), Van Der Veen, H. (Henk), van den Bijllaardt, W. (Wouter), de Vries, M. (Maaike), Smeets, L.C. (Leonard C.), Ott, A. (Alewijn), van Krimpen, K. (Kees), Herpers, B.L., Watttel-Louis, G.H. (G. Hanke), Waar, K. (Karola), Schwandt, N.L.Q. (Noortje L.Q.), Maat, I. (Ianthe), Dofferhoff, A.S.M. (Anton), Vermeulen, J.N. (Joost N.), Westreenen, M. (Mireille) van, Man, P. (Peter) de, Hofland, R.W. (Regina W.), van Gorp, J. (J.), Thijsen, S.F. (Steven), Velden, L.A. (Lilly Ann) van der, and Verduin, C.M. (Cornelis M.)
- Abstract
Background: Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an opportunistic infection across the tropics. Here, we provide a systematic overview of imported human cases in a non-endemic country over a 25-year period. Methods: All 55
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- 2019
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8. Melioidosis in travelers: An analysis of Dutch melioidosis registry data 1985-2018
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Birnie, E, Savelkoel, J, Reubsaet, F, Roelofs, J, Soetekouw, R, Kolkman, S, Cremers, AL, Grobusch, MP, Notermans, DW, Wiersinga, WJ, Rozemeijer, W, Rijkeboer, A, Scholing, M, Dijk, K, Mascini, EM, de Veen, H, Bijllaardt, Wouter, Boersma - de Vries, M, Smeets, LC, Ott, A, van Krimpen, K, Herpers, BL, Watttel-Louis, GH, Waar, K, Schwandt, NLQ, Maat, I, Dofferhoff, AS, Vermeulen, J N, van Westreenen, Mireille, de Man, P, Hofland, RW, Gorp, J, Thijsen, S, van der Velden, LB, Verduin, CM, Birnie, E, Savelkoel, J, Reubsaet, F, Roelofs, J, Soetekouw, R, Kolkman, S, Cremers, AL, Grobusch, MP, Notermans, DW, Wiersinga, WJ, Rozemeijer, W, Rijkeboer, A, Scholing, M, Dijk, K, Mascini, EM, de Veen, H, Bijllaardt, Wouter, Boersma - de Vries, M, Smeets, LC, Ott, A, van Krimpen, K, Herpers, BL, Watttel-Louis, GH, Waar, K, Schwandt, NLQ, Maat, I, Dofferhoff, AS, Vermeulen, J N, van Westreenen, Mireille, de Man, P, Hofland, RW, Gorp, J, Thijsen, S, van der Velden, LB, and Verduin, CM
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- 2019
9. Het opsporen van foutpositieve Mycobacterium tuberculosis complex-kweken met DNA-fingerprinting
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Broek I van den, Hunen R van, Vries G de, Ingen J van, Scholing M, Ott A, and Kamst M
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- 2018
10. Screening and prevention of infectious diseases in newly arrived migrants. Integrating hepatitis B, hepatitis C and HIV screening into tuberculosis entry screening for migrants in the Netherlands, 2013 to 2015
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Bil, J.P., Schrooders, P.A.G., Prins, M.A., Kouw, P.M., Klomp, J.H.E., Scholing, M., Waegemaekers, C.H.F.M., Zuure, F.R., and Tostmann, A.
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All institutes and research themes of the Radboud University Medical Center ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] - Abstract
Contains fulltext : 190138.pdf (Publisher’s version ) (Open Access)
- Published
- 2018
11. National laboratory-based surveillance system for antimicrobial resistance: a successful tool to support the control of antimicrobial resistance in the Netherlands
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Altorf-van der Kuil, W. (Wieke), Schoffelen, A.F. (Annelot F.), de Greeff, S.C. (Sabine C.), Thijsen, S.F. (Steven), Alblas, H.J. (H. Jeroen), Notermans, D.W. (Daan), Vlek, A.L.M. (Anne L.M.), Sande, M.A.B. (Marianne) van der, Leenstra, T. (Tjalling), Cohen Stuart, J.W.T. (James), Weersink, A.J.L. (A. J.L.), Visser, C.E., Vandenbroucke-Grauls, C.M.J.E. (Christina), van Ogtrop, M.L. (M. L.), Soeltan-Kaersenhout, D.J. (D. J.), Scholing, M. (M.), Hees, B.C. (Babette) van, Keulen, P.H.J. (Peter) van, Blijboom, L. (L.), Frakking, F.N.J. (Florine N.), Groenendijk, S. (S.), van Heereveld, J. (J.), Hertroys, R. (R.), Monen, J.C. (J. C.), van Triest, M.I. (M. I.), Wielders, C.C.H. (Cornelia), Woudt, S.H.S. (S. H.S.), Kluytmans, J.A.J.W. (Jan), Lundblad-Mattsson, E.E. (E. E.), Sebens, F. (Fré), de Jong, E. (E.), Frénay, H.M.E. (H. M.E.), Maraha, B. (Boulos), Griethuysen, A. (Arjanne) van, Silvis, W. (W.), Demeulemeester, A. (A.), Wintermans, B.B. (B. B.), Trijp, M.J.C.A. (Marijke) van, Hendrix, M. (Marijke), Ott, A. (Alewijn), Arends, J.P.A. (Jan), Kampinga, G.A. (Greetje), Veenendaal, D. (Dick), Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (F. S.), Bakker, L.J. (L. J.), Dorigo-Zetsma, J.W., Ridwan, B. (B.), Zeijl, J.H. (J.) van, Bernards, A.T. (Alexandra), Erkens-Hulshof, S. (Sandra), Jongh, B.M. (Bartelt) de, Nabuurs-Franssen, M.H. (M. H.), Kuipers, S. (S.), Diederen, B.M.W. (Bram), Melles, D.C. (Damian), Melles, D.C. (D. C.), van Rijn, M. (M.), de Man, P. (P.), Vaessen, N. (Norbert), Leverstein-Van Hall, M.A. (Maurine), Elzakker, E. van, Muller, A.E. (Anouk), Renders, N. (Nicole), van Dam, D.W. (D. W.), Hendrickx, B.G.A. (B. G.A.), Buiting, A.G.M. (Anton), Deege, M.P.D. (M. P.D.), Overdevest, I. (Ilse), Bosboom, R.W. (R. W.), Trienekens, T.A.M. (T. A.M.), Voorn, G.P. (G.), Ruijs, G. (G.), Wolfhagen, M.J.H.M., Altorf-van der Kuil, W. (Wieke), Schoffelen, A.F. (Annelot F.), de Greeff, S.C. (Sabine C.), Thijsen, S.F. (Steven), Alblas, H.J. (H. Jeroen), Notermans, D.W. (Daan), Vlek, A.L.M. (Anne L.M.), Sande, M.A.B. (Marianne) van der, Leenstra, T. (Tjalling), Cohen Stuart, J.W.T. (James), Weersink, A.J.L. (A. J.L.), Visser, C.E., Vandenbroucke-Grauls, C.M.J.E. (Christina), van Ogtrop, M.L. (M. L.), Soeltan-Kaersenhout, D.J. (D. J.), Scholing, M. (M.), Hees, B.C. (Babette) van, Keulen, P.H.J. (Peter) van, Blijboom, L. (L.), Frakking, F.N.J. (Florine N.), Groenendijk, S. (S.), van Heereveld, J. (J.), Hertroys, R. (R.), Monen, J.C. (J. C.), van Triest, M.I. (M. I.), Wielders, C.C.H. (Cornelia), Woudt, S.H.S. (S. H.S.), Kluytmans, J.A.J.W. (Jan), Lundblad-Mattsson, E.E. (E. E.), Sebens, F. (Fré), de Jong, E. (E.), Frénay, H.M.E. (H. M.E.), Maraha, B. (Boulos), Griethuysen, A. (Arjanne) van, Silvis, W. (W.), Demeulemeester, A. (A.), Wintermans, B.B. (B. B.), Trijp, M.J.C.A. (Marijke) van, Hendrix, M. (Marijke), Ott, A. (Alewijn), Arends, J.P.A. (Jan), Kampinga, G.A. (Greetje), Veenendaal, D. (Dick), Brauwer, E.I.G.B. (E. I G B) de, Stals, F.S. (F. S.), Bakker, L.J. (L. J.), Dorigo-Zetsma, J.W., Ridwan, B. (B.), Zeijl, J.H. (J.) van, Bernards, A.T. (Alexandra), Erkens-Hulshof, S. (Sandra), Jongh, B.M. (Bartelt) de, Nabuurs-Franssen, M.H. (M. H.), Kuipers, S. (S.), Diederen, B.M.W. (Bram), Melles, D.C. (Damian), Melles, D.C. (D. C.), van Rijn, M. (M.), de Man, P. (P.), Vaessen, N. (Norbert), Leverstein-Van Hall, M.A. (Maurine), Elzakker, E. van, Muller, A.E. (Anouk), Renders, N. (Nicole), van Dam, D.W. (D. W.), Hendrickx, B.G.A. (B. G.A.), Buiting, A.G.M. (Anton), Deege, M.P.D. (M. P.D.), Overdevest, I. (Ilse), Bosboom, R.W. (R. W.), Trienekens, T.A.M. (T. A.M.), Voorn, G.P. (G.), Ruijs, G. (G.), and Wolfhagen, M.J.H.M.
- Abstract
An important cornerstone in the control of antimicrobial resistance (AMR) is a well-designed quantitative system for the surveillance of spread and temporal trends in AMR. Since 2008, the Dutch national AMR surveillance system, based on routine data from medical microbiological laboratories (MMLs), has developed into a successful tool to support the control of AMR in the Netherlands. It provides background information for policy making in public health and healthcare services, supports development of empirical antibiotic therapy guidelines and facilitates in-depth research. In addition, participation of the MMLs in the national AMR surveillance network has contributed to sharing of knowledge and quality improvement. A future improvement will be the implementation of a new semantic standard together with standardised data transfer, which will reduce errors in data handling and enable a more real-time surveillance. Furthermore, the s
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- 2017
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12. P3.18 Monitoringchlamydia trachomatisinfections after treatment for test of cure purposes
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Versteeg, B, primary, Bruisten, SM, additional, Heijman, T, additional, Vermeulen, W, additional, Rooijen, MS van, additional, Dam, AP van, additional, Loeff, MF Schim van der, additional, Vries, HJC de, additional, and Scholing, M, additional
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- 2017
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13. An HIV-negative Same-sex Male Couple Both Infected with Hepatitis C Virus
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Achterbergh, R, primary, Bruisten, S, additional, Laar, T, additional, Weijden, C, additional, Scholing, M, additional, Cornelissen, M, additional, and Vries, H, additional
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- 2017
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14. Integrating voluntary hepatitis B, C and HIV screening in the compulsory tuberculosis entry screening for immigrants, The Netherlands: a pilot project
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Bil, J., primary, Schrooders, P., additional, Prins, M., additional, Kouw, P., additional, Klomp, J., additional, Scholing, M., additional, Huijbregts, L., additional, Sonder, G., additional, Waegemaekers, T., additional, de Vries, H., additional, Meijer, W., additional, Zuure, F., additional, and Tostmann, A., additional
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- 2017
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15. voedsel gerelateerde uitbraak van Salmonella Heidelberg op kinderdagverblijven
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Rijckevorsel, G.G.C. van, Mieras, L., Bovée, L.P.M.J., Dijk, C. van, Scholing, M., Swaan, C.M., Heck, M., Lavooij, P., Sonder, G.J.B., Rijckevorsel, G.G.C. van, Mieras, L., Bovée, L.P.M.J., Dijk, C. van, Scholing, M., Swaan, C.M., Heck, M., Lavooij, P., and Sonder, G.J.B.
- Abstract
Begin juni 2014 werd een gelijktijdige uitbraak van gastro-enteritis op enkele Amsterdamse kinderdagverblijven bij de GGD gemeld. In het verloop van een paar dagen liep het aantal gemelde zieke kinderen sterk op (65 zieke kinderen, 7 ziekenhuisopnames). Vanwege het vermoeden dat het een aan voedsel gerelateerde uitbraak was, startte de GGD Amsterdam een gezamenlijk uitbraakonderzoek met de Nederlandse Voedsel en Warenautoriteit (NVWA). Door een online vragenlijst te gebruiken verliep het brononderzoek zeer snel. Binnen een dag werd duidelijk dat een warme maaltijd, die op 26 mei door de kinderdagverblijven was geserveerd, de bron zou kunnen zijn. Hierna kon de NVWA heel gericht onderzoek uitvoeren. Tien dagen na de eerste ziektemelding werd het verband tussen de maaltijd en ziekte aangetoond.
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- 2015
16. Diagnosis of cryptococcal and tuberculous meningitis in a resource-limited African setting
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Cohen, D.B., Zijlstra, E.E., Mukaka, M., Reiss, M., Kamphambale, S., Scholing, M., Waitt, P.I., Neuhann, F., Medical Microbiology and Infection Prevention, and CCA - Disease profiling
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- 2010
17. No added value of performing Ziehl-Neelsen on auramine-positive samples for tuberculosis diagnostics
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den Hertog, A. L., primary, Daher, S., additional, Straetemans, M., additional, Scholing, M., additional, and Anthony, R. M., additional
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- 2013
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18. Two cases of mild IgM-negative measles in previously vaccinated adults, the Netherlands, April and July 2011
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van den Hoek, A, primary, Sonder, G J, additional, Scholing, M, additional, Gijselaar, DB, additional, and van Binnendijk, R S, additional
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- 2011
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19. P3.18 Monitoring chlamydia trachomatisinfections after treatment for test of cure purposes
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Versteeg, B, Bruisten, SM, Heijman, T, Vermeulen, W, Rooijen, MS van, Dam, AP van, Loeff, MF Schim van der, Vries, HJC de, and Scholing, M
- Abstract
IntroductionPerforming a test of cure (TOC) could demonstrate success or failure of antimicrobial treatment of C. trachomatis(CT) infection, but the value of using a nuclear acid amplification test (NAAT) based TOC after treatment is subject to discussion, as the presence of CT nucleic acids after treatment may be prolonged and intermittent without the presence of infectious bacteria. We used cell culture to assess if a NAAT positive TOC indicates the presence of viable CT.MethodsWe analysed follow up (FU) data from women with a CT infection who visited the STI clinic of Amsterdam, the Netherlands, from September 2015 through June 2016. After giving informed consent, participants underwent baseline and three FU speculum examinations to obtain cervical swabs for both CT culture and NAAT testing. Speculum examinations were scheduled at 7, 21 and 49 days after treatment (single dose 1000 mg azithromycin). Collected samples were analysed using a RNA and DNA-based NAAT. CT cell culture was performed on all samples at baseline, and in FU samples that were NAAT-positive. Clearance was defined as conversion to negative NAAT results at any FU visit.ResultsWe included 78 women with NAAT proven CT infection prior to receiving treatment of whom 58 (74%) were also culture positive. At the first visit after treatment (median 7 days; IQR 7–8) 44 (47%) women were NAAT positive, of whom three tested also positive by culture. CT infection was cleared in 73 women (94%), of whom 61 (78%) at their second FU visit (median 21 days; IQR 21–25). Of the five women who did not clear their infection, three were also culture positive indicating a viable infection. All five reported unprotected sexual contact after inclusion prior to their last FU visit, indicating potentially new infections.ConclusionWe observed prolonged and intermittent positive results over time for both NAAT tests. For three participants (4%) viable CT infections were detected 49 days after treatment. All three cases reported new sexual contacts. In conclusion, persisting infections or treatment failure were rare.Support:Hologic provided Aptima test materials and kits in-kind. Roche provided Cobas test materials and kits in-kind. Copan provided Universal Transport Medium in-kind
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- 2017
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20. Antroduodenal manometry findings in children with suspected pediatric intestinal pseudo-obstruction.
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Gulliksson G, Nyström N, Danielson J, Lilljekvist FD, Scholing M, Hellström PM, and Gustafson E
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- Humans, Male, Child, Female, Retrospective Studies, Child, Preschool, Adolescent, Duodenum physiopathology, Manometry methods, Intestinal Pseudo-Obstruction diagnosis, Intestinal Pseudo-Obstruction physiopathology
- Abstract
Background: In 2018 diagnostic criteria for pediatric intestinal pseudo-obstruction (PIPO) were established. Neuromuscular dysfunction of the gastrointestinal tract is one of these, and often examined through antroduodenal manometry (ADM). There is little data on antroduodenal manometries in children. Our objectives were to retrospectively apply these criteria to children evaluated for suspected motility disorder, to reevaluate the ADM patterns and compare children who did and did not meet the PIPO criteria and also with healthy adults., Methods: Children with a suspected gastrointestinal motility disorder previously investigated with 24-h 8-lead ADM were reevaluated by applying the 2018 ESPGHAN/NASPGHAN PIPO diagnostic criteria and the 2018 ANMS-NASPGHAN guidelines. ADM findings were compared between children who retrospectively fulfilled a PIPO diagnosis, children who did not, and a control group of healthy adults., Key Results: Of 34 children (age 7.9 (±5.1) years, 18 males), 12 retrospectively fulfilled the 2018 PIPO diagnostic criteria. Twenty-five children (10 in the PIPO group) had abnormal diagnostic findings on ADM, whereas 9 (2 in the PIPO group) had no such findings. A PIPO diagnosis implied a significantly higher degree of abnormal ADM patterns (2.33 vs. 1.23, p = 0.02). There were no major differences in quantitative ADM measurements between the groups except higher pressures in children., Conclusions and Inferences: Children who retrospectively fulfilled a PIPO diagnosis had a significantly higher abundance of abnormal ADM findings compared with symptomatic children without PIPO and healthy adults. Our data indicate a need for set criteria for evaluation of ADM in children with suspected PIPO., (© 2024 John Wiley & Sons Ltd.)
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- 2024
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21. Current Practices and Opportunities for Outpatient Parenteral Antimicrobial Therapy in Hospitals: A National Cross-Sectional Survey.
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Stoorvogel HH, Hulscher MEJL, Wertheim HFL, Yzerman EPF, Scholing M, Schouten JA, and Ten Oever J
- Abstract
This nationwide study assessed how outpatient parenteral antimicrobial therapy (OPAT) is organised by Dutch acute care hospitals, the barriers experienced, and how an OPAT program affects the way hospitals organised OPAT care. We systematically developed and administered a survey to all 71 Dutch acute care hospitals between November 2021 and February 2022. Analyses were primarily descriptive and included a comparison between hospitals with and without an OPAT program. Sixty of the 71 hospitals (84.5%) responded. Fifty-five (91.7%) performed OPAT, with a median number of 20.8 (interquartile range [IQR] 10.3-29.7) patients per 100 hospital beds per year. Of these 55 hospitals, 31 (56.4%) had selection criteria for OPAT and 34 (61.8%) had a protocol for laboratory follow-up. Sixteen hospitals (29.1%) offered self-administered OPAT (S-OPAT), with a median percentage of 5.0% of patients (IQR: 2.3%-10.0%) actually performing self-administration. Twenty-five hospitals (45.5%) had an OPAT-related outcome registration. The presence of an OPAT program (22 hospitals, 40.0%) was significantly associated with aspects of well-organised OPAT care. The most commonly experienced barriers to OPAT implementation were a lack of financial, administrative, and IT support and insufficient time of healthcare staff. Concluding, hospital-initiated OPAT is widely available in the Netherlands, but various aspects of well-organised OPAT care can be improved. Implementation of a team-based OPAT program can contribute to such improvements. The observed variation provides leads for further scientific research, guidelines, and practical implementation programs.
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- 2022
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22. High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands.
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van Dulm E, Tholen ATR, Pettersson A, van Rooijen MS, Willemsen I, Molenaar P, Damen M, Gruteke P, Oostvogel P, Kuijper EJ, Hertogh CMPM, Vandenbroucke-Grauls CMJE, and Scholing M
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- Aged, Aged, 80 and over, Drug Resistance, Multiple, Bacterial genetics, Enterobacteriaceae metabolism, Enterobacteriaceae Infections microbiology, Female, Gram-Negative Bacteria isolation & purification, Gram-Negative Bacterial Infections etiology, Health Facilities, Humans, Infection Control methods, Long-Term Care, Male, Methicillin-Resistant Staphylococcus aureus isolation & purification, Middle Aged, Netherlands epidemiology, Prevalence, Risk Factors, Skilled Nursing Facilities, Staphylococcal Infections microbiology, Vancomycin-Resistant Enterococci isolation & purification, Cross Infection epidemiology, Drug Resistance, Multiple genetics, Enterobacteriaceae genetics
- Abstract
Introduction: The aim of this study was to determine the rate of asymptomatic carriage and spread of multidrug-resistant micro-organisms (MDRO) and to identify risk factors for extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in 12 long term care facilities (LTCFs) in Amsterdam, the Netherlands., Materials and Methods: From November 2014 to august 2015, feces and nasal swabs from residents from LTCFs in Amsterdam, the Netherlands were collected and analyzed for presence of multidrug-resistant Gram-negative bacteria (MDRGN), including ESBL-E, carbapenemase-producing Enterobacteriaceae (CPE), colistin-resistant Enterobacteriaceae and methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Logistic regression analysis was performed to assess associations between variables and ESBL-carriage., Results: In total, 385 residents from 12 LTCFs (range 15-48 residents per LTCF) were enrolled. The prevalence of carriage of MDRGN was 18.2% (range among LTCFs 0-47%) and the prevalence of ESBL-E alone was 14.5% (range among LTCFs: 0-34%). Of 63 MDRGN positive residents, 50 (79%) were ESBL-E positive of which 43 (86%) produced CTX-M. Among 44 residents with ESBL-E positive fecal samples of whom data on contact precautions were available at the time of sampling, only 9 (20%) were already known as ESBL-E carriers. The prevalence for carriage of MRSA was 0.8% (range per LTCF: 0-7%) and VRE 0%. One CPE colonized resident was found. All fecal samples tested negative for presence of plasmid mediated resistance for colistin (MCR-1). Typing of isolates by Amplified Fragment Length Polymorphism (AFLP) showed five MDRGN clusters, of which one was found in multiple LTCFs and four were found in single LTCFs, suggesting transmission within and between LTCFs. In multivariate analysis only the presence of MDRO in the preceding year remained a risk factor for ESBL-E carriage., Conclusions: The ESBL-carriage rate of residents in LTCFs is nearly two times higher than in the general population but varies considerably among LTCFs in Amsterdam, whereas carriage of MRSA and VRE is low. The majority (80%) of ESBL-E positive residents had not been detected by routine culture of clinical specimens at time of sampling. Current infection control practices in LTCFs in Amsterdam do not prevent transmission. Both improvement of basic hygiene, and funding for laboratory screening, should allow LTCFs in Amsterdam to develop standards of care to prevent transmission of ESBL-E., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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23. Integrating hepatitis B, hepatitis C and HIV screening into tuberculosis entry screening for migrants in the Netherlands, 2013 to 2015.
- Author
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Bil JP, Schrooders PA, Prins M, Kouw PM, Klomp JH, Scholing M, Huijbregts LP, Sonder GJ, Waegemaekers TC, de Vries HJ, Meijer W, Zuure FR, and Tostmann A
- Subjects
- Adolescent, Adult, Africa ethnology, Antibodies, Viral blood, Asia, Southeastern ethnology, Caribbean Region ethnology, Europe, Eastern, Female, HIV Infections epidemiology, HIV Infections ethnology, Hepatitis B epidemiology, Hepatitis B ethnology, Hepatitis B Surface Antigens blood, Hepatitis C epidemiology, Hepatitis C ethnology, Hepatitis C Antibodies blood, Humans, Latin America ethnology, Male, Mediterranean Region, Middle Aged, Netherlands epidemiology, Prevalence, Serologic Tests, Tuberculosis epidemiology, Tuberculosis ethnology, Young Adult, Delivery of Health Care, Integrated, HIV Infections diagnosis, Hepatitis B diagnosis, Hepatitis C diagnosis, Mass Screening methods, Transients and Migrants, Tuberculosis diagnosis
- Abstract
We evaluated uptake and diagnostic outcomes of voluntary hepatitis B (HBV) and C virus (HCV) screening offered during routine tuberculosis entry screening to migrants in Gelderland and Amsterdam, the Netherlands, between 2013 and 2015. In Amsterdam, HIV screening was also offered. Overall, 54% (461/859) accepted screening. Prevalence of chronic HBV infection (HBsAg-positive) and HCV exposure (anti-HCV-positive) in Gelderland was 4.48% (9/201; 95% confidence interval (CI): 2.37-8.29) and 0.99% (2/203; 95% CI: 0.27-3.52), respectively, all infections were newly diagnosed. Prevalence of chronic HBV infection, HCV exposure and chronic HCV infection (HCV RNA-positive) in Amsterdam was 0.39% (1/256; 95% CI: 0.07-2.18), 1.17% (3/256; 95% CI: 0.40-3.39) and 0.39% (1/256; 95% CI: 0.07-2.18), respectively, with all chronic HBV/HCV infections previously diagnosed. No HIV infections were found. In univariate analyses, newly diagnosed chronic HBV infection was more likely in participants migrating for reasons other than work or study (4.35% vs 0.83%; odds ratio (OR) = 5.45; 95% CI: 1.12-26.60) and was less likely in participants in Amsterdam than Gelderland (0.00% vs 4.48%; OR = 0.04; 95% CI: 0.00-0.69). Regional differences in HBV prevalence might be explained by differences in the populations entering compulsory tuberculosis screening. Prescreening selection of migrants based on risk factors merits further exploration.
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- 2018
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24. Monitoring therapy success of urogenital Chlamydia trachomatis infections in women: A prospective observational cohort study.
- Author
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Versteeg B, Bruisten SM, Heijman T, Vermeulen W, van Rooijen MS, van Dam AP, Schim van der Loeff MF, de Vries HJC, and Scholing M
- Subjects
- Chlamydia trachomatis genetics, DNA, Bacterial metabolism, Female, Humans, Microbial Viability, Prospective Studies, RNA, Bacterial metabolism, Treatment Outcome, Young Adult, Chlamydia Infections therapy, Chlamydia trachomatis physiology
- Abstract
Introduction: The use of a nucleic acid amplification test (NAAT) as a test of cure after treatment is subject to discussion, as the presence of C. trachomatis nucleic acids after treatment may be prolonged and intermittent without presence of infectious bacteria. We used cell culture to assess if a positive RNA- or DNA-based NAAT after treatment indicates the presence of viable C. trachomatis., Methods: We included women with asymptomatic urogenital C. trachomatis infection visiting the Amsterdam STI clinic from September 2015 through June 2016. Endocervical swabs were collected prior to treatment with azithromycin, and during three follow-up visits 7, 21 and 49 days after treatment. Collected swabs were subjected to C. trachomatis culture and a RNA- and DNA-based NAAT. High-resolution multilocus sequence typing (hr-MLST) was used to further differentiate potential re-infections., Results: We included 90 women with a positive RNA-test prior to receiving treatment of whom 81 (90%) were also DNA-positive, and 69 (76.7%) culture-positive. Prolonged and intermittent positive RNA and DNA results over time were observed. Three women had culture positive results at the second visit, but all were negative at the third visit. Five women had NAAT-positive results at the fourth visit of whom three women were also culture-positive indicating a viable infection. All five women reported unprotected sexual contact since the first visit. From 2, hr-MLST sequence types were obtained. One had a different sequence type indicating a new infection the other was identical to the previously found indicating a potentially persisting infection., Conclusion: Most RNA- or DNA-positive results after treatment of urogenital C. trachomatis may be caused by non-viable molecular remnants since they cannot be confirmed by culture. In a minority viable C. trachomatis was found in culture at the second visit, indicating that patients may remain infectious at least 7 days after treatment.
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- 2017
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25. Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis.
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Sloot R, Schim van der Loeff MF, van Zwet EW, Haks MC, Keizer ST, Scholing M, Ottenhoff TH, Borgdorff MW, and Joosten SA
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- Adult, Biomarkers blood, Female, HIV Infections complications, Humans, Male, Middle Aged, Retrospective Studies, Substance-Related Disorders complications, Tuberculosis, Pulmonary etiology, AIRE Protein, HIV Infections blood, Interferon Type I blood, Interleukin-13 blood, Substance-Related Disorders blood, Transcription Factors blood, Tuberculosis, Pulmonary blood
- Abstract
Background: Current diagnostic tests cannot identify which infected individuals are at risk for progression to tuberculosis (TB). Our aim was to identify biomarkers which can predict the development of TB prior to clinical diagnosis., Method: In a retrospective case-control study, RNA of 14 HIV-infected drug users obtained before TB diagnosis (cases) and of 15 who did not develop TB (controls) was analyzed for the expression of 141 genes by dcRT-MLPA followed by Lasso regression analysis., Findings: A combined analysis of IL13 and AIRE had the highest discriminatory power to identify cases up to 8 months prior to clinical diagnosis. Cases expressing IL13 had a gene expression pattern strongly enriched for type I IFN related signaling genes, suggesting that these genes represent processes that contribute to TB pathogenesis., Interpretation: We here demonstrated that biomarkers, such as IL13-AIRE, can identify individuals that progress to TB within a high risk population, months prior to clinical diagnosis.
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- 2014
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26. Diagnosis of cryptococcal and tuberculous meningitis in a resource-limited African setting.
- Author
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Cohen DB, Zijlstra EE, Mukaka M, Reiss M, Kamphambale S, Scholing M, Waitt PI, and Neuhann F
- Subjects
- AIDS-Related Opportunistic Infections cerebrospinal fluid, AIDS-Related Opportunistic Infections complications, Adult, Algorithms, Diagnosis, Differential, Epidemiologic Methods, Female, Humans, Leukocyte Count, Malawi, Male, Medically Underserved Area, Meningitis, Cryptococcal cerebrospinal fluid, Meningitis, Cryptococcal complications, Neck Pain microbiology, Tuberculosis, Meningeal cerebrospinal fluid, Tuberculosis, Meningeal complications, AIDS-Related Opportunistic Infections diagnosis, Developing Countries, Meningitis, Cryptococcal diagnosis, Tuberculosis, Meningeal diagnosis
- Abstract
Objectives: Cryptococcal meningitis (CM) and tuberculous meningitis (TBM) are common in HIV-infected adults in Africa and difficult to diagnose. Inaccurate diagnosis results in adverse outcomes. We describe patterns of meningitis in a Malawian hospital, focusing on features which differentiate CM and TBM with the aim to derive an algorithm using only clinical and basic laboratory data available in this resource-poor setting., Methods: Consecutive patients admitted with meningitis were prospectively recruited, clinical features were recorded and cerebrospinal fluid (CSF) was examined., Results: A total of 573 patients were recruited, and 263 (46%) had CSF consistent with meningitis. One hundred and twelve (43%) had CM and 46 (18%) had TBM. CM was associated with high CSF opening pressure and low CSF leukocyte count. Fever, neck stiffness and reduced conscious level were associated with TBM. A diagnostic index was constructed demonstrating sensitivity 83%and specificity 79% for the differentiation of CM and TBM. An algorithm was derived with 92% sensitivity for the diagnosis of CM, but only 58% specificity., Conclusions: Although we demonstrate features associated with CM and TBM, a sufficiently sensitive and specific diagnostic algorithm could not be derived, suggesting that the diagnosis of CM and TBM in resource-limited settings still requires better access to laboratory tools.
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- 2010
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27. An evaluation of a Shockroom located CT scanner: a randomized study of early assessment by CT scanning in trauma patients in the bi-located trauma center North-West Netherlands (REACT trial).
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Saltzherr TP, Fung Kon Jin PH, Bakker FC, Ponsen KJ, Luitse JS, Scholing M, Giannakopoulos GF, Beenen LF, Henny CP, Koole GM, Reitsma HB, Dijkgraaf MG, Bossuyt PM, and Goslings JC
- Subjects
- Critical Care methods, Emergency Treatment standards, Emergency Treatment trends, Evaluation Studies as Topic, Female, Humans, Injury Severity Score, Male, Netherlands, Outcome Assessment, Health Care, Probability, Prospective Studies, Reference Values, Risk Factors, Sensitivity and Specificity, Survival Analysis, Time Factors, Tomography, X-Ray Computed instrumentation, Transportation of Patients statistics & numerical data, Treatment Outcome, Wounds and Injuries mortality, Wounds and Injuries therapy, Point-of-Care Systems statistics & numerical data, Tomography Scanners, X-Ray Computed statistics & numerical data, Tomography, X-Ray Computed methods, Trauma Centers, Wounds and Injuries diagnostic imaging
- Abstract
Background: Trauma is a major source of morbidity and mortality, especially in people below the age of 50 years. For the evaluation of trauma patients CT scanning has gained wide acceptance in and provides detailed information on location and severity of injuries. However, CT scanning is frequently time consuming due to logistical (location of CT scanner elsewhere in the hospital) and technical issues. An innovative and unique infrastructural change has been made in the AMC in which the CT scanner is transported to the patient instead of the patient to the CT scanner. As a consequence, early shockroom CT scanning provides an all-inclusive multifocal diagnostic modality that can detect (potentially life-threatening) injuries in an earlier stage, so that therapy can be directed based on these findings., Methods/design: The REACT-trial is a prospective, randomized trial, comparing two Dutch level-1 trauma centers, respectively the VUmc and AMC, with the only difference being the location of the CT scanner (respectively in the Radiology Department and in the shockroom). All trauma patients that are transported to the AMC or VUmc shockroom according to the current prehospital triage system are included. Patients younger than 16 years of age and patients who die during transport are excluded. Randomization will be performed prehospitally. Study parameters are the number of days outside the hospital during the first year following the trauma (primary outcome), general health at 6 and 12 months post trauma, mortality and morbidity, and various time intervals during initial evaluation. In addition a cost-effectiveness analysis of this shockroom concept will be performed. Regarding primary outcome it is estimated that the common standard deviation of days spent outside of the hospital during the first year following trauma is a total of 12 days. To detect an overall difference of 2 days within the first year between the two strategies, 562 patients per group are needed. (alpha 0.95 and beta 0.80)., Discussion: The REACT-trial will provide evidence on the effects of a strategy involving early shockroom CT scanning compared with a standard diagnostic imaging strategy in trauma patients on both patient outcome and operations research., Trial Registration: ISRCTN55332315.
- Published
- 2008
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