1. Distinct multivariate structural brain profiles are related to variations in short- and long-delay memory consolidation across children and young adults.
- Author
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Schommartz, Iryna, Lembcke, Philip, Pupillo, Francesco, Schuetz, Henriette, de Chamorro, Nina, Bauer, Martin, Kaindl, Angela, Buss, Claudia, and Shing, Yee
- Subjects
Episodic memory ,Hippocampal subfields ,Memory consolidation ,Neocortex ,Object-scene associations ,Partial least square correlation ,Prefrontal cortex ,Humans ,Child ,Young Adult ,Child ,Preschool ,Memory Consolidation ,Brain ,Memory ,Hippocampus ,Sleep ,Magnetic Resonance Imaging - Abstract
From early to middle childhood, brain regions that underlie memory consolidation undergo profound maturational changes. However, there is little empirical investigation that directly relates age-related differences in brain structural measures to memory consolidation processes. The present study examined memory consolidation of intentionally studied object-location associations after one night of sleep (short delay) and after two weeks (long delay) in normally developing 5-to-7-year-old children (n = 50) and young adults (n = 39). Behavioural differences in memory retention rate were related to structural brain measures. Our results showed that children, in comparison to young adults, retained correctly learnt object-location associations less robustly over short and long delay. Moreover, using partial least squares correlation method, a unique multivariate profile comprised of specific neocortical (prefrontal, parietal, and occipital), cerebellar, and hippocampal head and subfield structures in the body was found to be associated with variation in short-delay memory retention. A different multivariate profile comprised of a reduced set of brain structures, mainly consisting of neocortical (prefrontal, parietal, and occipital), hippocampal head, and selective hippocampal subfield structures (CA1-2 and subiculum) was associated with variation in long-delay memory retention. Taken together, the results suggest that multivariate structural pattern of unique sets of brain regions are related to variations in short- and long-delay memory consolidation across children and young adults.
- Published
- 2023