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588 results on '"Schoonheim, Menno M."'

10. Clinical risk stratification: Development and validation of the DAAE score, a tool for estimating patient risk of transition to secondary progressive multiple sclerosis

Author

Fuchs, Tom A., Zivadinov, Robert, Pryshchepova, Tetyana, Weinstock-Guttman, Bianca, Dwyer, Michael G., Benedict, Ralph H.B., Bergsland, Niels, Jakimovski, Dejan, Uher, Tomas, Jelgerhuis, Julia R., Barkhof, Frederik, Uitdehaag, Bernard M.J., Killestein, Joep, Strijbis, Eva M.M., and Schoonheim, Menno M.

Published
2024
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11. A vision of 14 T MR for fundamental and clinical science

Author

Bates, Steve, Dumoulin, Serge O., Folkers, Paul J. M., Formisano, Elia, Goebel, Rainer, Haghnejad, Aidin, Helmich, Rick C., Klomp, Dennis, van der Kolk, Anja G., Li, Yi, Nederveen, Aart, Norris, David G., Petridou, Natalia, Roell, Stefan, Scheenen, Tom W. J., Schoonheim, Menno M., Voogt, Ingmar, and Webb, Andrew

Published
2023
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13. Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis

Author

Zivadinov, Robert, Bergsland, Niels, Jakimovski, Dejan, Weinstock-Guttman, Bianca, Lorefice, Lorena, Schoonheim, Menno M., Morrow, Sarah A., Ann Picone, Mary, Pardo, Gabriel, Zarif, Myassar, Gudesblatt, Mark, Nicholas, Jacqueline A., Smith, Andrew, Hunter, Samuel, Newman, Stephen, AbdelRazek, Mahmoud A., Hoti, Ina, Riolo, Jon, Silva, Diego, Fuchs, Tom A., Dwyer, Michael G., and HB. Benedict, Ralph

Published
2024
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14. Don’t be late! Postponing cognitive decline and preventing early unemployment in people with multiple sclerosis: a study protocol

Author

Aarts, Jip, Saddal, Shalina R. D., Bosmans, Judith E., de Groot, Vincent, de Jong, Brigit A., Klein, Martin, Ruitenberg, Marit F. L., Schaafsma, Frederieke G., Schippers, Esther C. F., Schoonheim, Menno M., Uitdehaag, Bernard M. J., van der Veen, Sabina, Waskowiak, Pauline T., Widdershoven, Guy A. M., van der Hiele, Karin, and Hulst, Hanneke E.

Published
2024
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15. Don’t be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol

Author

Waskowiak, Pauline T., de Jong, Brigit A., Uitdehaag, Bernard M. J., Saddal, Shalina R. D., Aarts, Jip, Roovers, Aïda A. M., van Oirschot, Pim, de Groot, Vincent, Schaafsma, Frederieke G., van der Hiele, Karin, Ruitenberg, Marit F. L., Schoonheim, Menno M., Widdershoven, Guy A. M., van der Veen, Sabina, Schippers, Esther C. F., Klein, Martin, and Hulst, Hanneke E.

Published
2024
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21. Exploring the effects of extended interval dosing of natalizumab and drug concentrations on brain atrophy in multiple sclerosis

Author

Toorop, Alyssa A, primary, Noteboom, Samantha, additional, Steenwijk, Martijn D, additional, Gravendeel, Job W, additional, Jasperse, Bas, additional, Barkhof, Frederik, additional, Strijbis, Eva MM, additional, Rispens, Theo, additional, Schoonheim, Menno M, additional, van Kempen, Zoé LE, additional, and Killestein, Joep, additional

Published
2024
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22. Scanner-Specific Optimisation of Automated Lesion Segmentation in MS

Author

Nederpelt, van, David Rudolf, primary, Pontillo, Giuseppe, additional, Barrantes-Cepas, Mar, additional, Brouwer, Iman, additional, Strijbis, Eva, additional, Schoonheim, Menno M., additional, Moraal, Bastiaan, additional, Jasperse, Bas, additional, Mutsaerts, Henk-Jan M.M., additional, Killestein, Joep, additional, Barkhof, Frederik, additional, Kuijer, Joost P.A., additional, and Vrenken, Hugo, additional

Published
2024
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23. Higher‐order functional connectivity analysis of resting‐state functional magnetic resonance imaging data using multivariate cumulants.

Author

Hindriks, Rikkert, Broeders, Tommy A. A., Schoonheim, Menno M., Douw, Linda, Santos, Fernando, van Wieringen, Wessel, and Tewarie, Prejaas K. B.

Subjects
FUNCTIONAL magnetic resonance imaging, FUNCTIONAL connectivity, CUMULANTS, STATISTICAL bootstrapping
Abstract

Blood‐level oxygenation‐dependent (BOLD) functional magnetic resonance imaging (fMRI) is the most common modality to study functional connectivity in the human brain. Most research to date has focused on connectivity between pairs of brain regions. However, attention has recently turned towards connectivity involving more than two regions, that is, higher‐order connectivity. It is not yet clear how higher‐order connectivity can best be quantified. The measures that are currently in use cannot distinguish between pairwise (i.e., second‐order) and higher‐order connectivity. We show that genuine higher‐order connectivity can be quantified by using multivariate cumulants. We explore the use of multivariate cumulants for quantifying higher‐order connectivity and the performance of block bootstrapping for statistical inference. In particular, we formulate a generative model for fMRI signals exhibiting higher‐order connectivity and use it to assess bias, standard errors, and detection probabilities. Application to resting‐state fMRI data from the Human Connectome Project demonstrates that spontaneous fMRI signals are organized into higher‐order networks that are distinct from second‐order resting‐state networks. Application to a clinical cohort of patients with multiple sclerosis further demonstrates that cumulants can be used to classify disease groups and explain behavioral variability. Hence, we present a novel framework to reliably estimate genuine higher‐order connectivity in fMRI data which can be used for constructing hyperedges, and finally, which can readily be applied to fMRI data from populations with neuropsychiatric disease or cognitive neuroscientific experiments. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes

Author

Mattiesing, Rozemarijn M, primary, Kramer, Eline, additional, Strijbis, Eva MM, additional, Brouwer, Iman, additional, van Schijndel, Ronald A, additional, Gentile, Giordano, additional, Battaglini, Marco, additional, De Stefano, Nicola, additional, Uitdehaag, Bernard MJ, additional, Barkhof, Frederik, additional, Vrenken, Hugo, additional, and Schoonheim, Menno M, additional

Published
2023
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28. Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study.

Author

Kaçar, Sezgi, Coric, Danko, Ometto, Giovanni, Montesano, Giovanni, Denniston, Alastair K., Keane, Pearse A., Uitdehaag, Bernard M. J., Crabb, David P., Schoonheim, Menno M., Petzold, Axel, and Strijbis, Eva M. M.

Subjects
MULTIPLE sclerosis, OPTICAL coherence tomography, NEURODEGENERATION, GENERALIZED estimating equations, HAZE, OPTIC neuritis
Abstract

Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (p = 0.629). In MS, VH scores declined with disease duration (β = −0.009, p = 0.004) and age (β = −0.007, p = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, p = 0.011) and white matter volume (NWMV, β = 0.001, p = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, p < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, p = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, p = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Disease progression in the first 5 years of treatment in multiple sclerosis: Predictive value of early brain and lesion volume changes.

Author

Mattiesing, Rozemarijn M, Kramer, Eline, Strijbis, Eva MM, Brouwer, Iman, van Schijndel, Ronald A, Gentile, Giordano, Battaglini, Marco, De Stefano, Nicola, Uitdehaag, Bernard MJ, Barkhof, Frederik, Vrenken, Hugo, and Schoonheim, Menno M

Subjects
BRAIN damage, DISEASE progression, MULTIPLE sclerosis, MAGNETIC resonance imaging, THERAPEUTICS
Abstract

Background: Whether the degree of inflammation (and its resolution) and neurodegeneration after treatment initiation predicts disease progression in multiple sclerosis (MS) remains unclear. Objectives: To assess the predictive value of magnetic resonance imaging (MRI)-derived brain and lesion volume (LV) changes in years 1 and 2 of treatment for disease progression. Methods: Patients receiving early interferon beta-1a treatment in REFLEX/REFLEXION (N = 262) were included. Predictive regression models included new/enlarging LV (positive activity), disappearing/shrinking LV (negative activity), and global/central atrophy during years 1 and 2. Results: Faster global atrophy and/or pseudo-atrophy and positive lesion activity in years 1 and 2 related to an increased probability and faster conversion to clinically definite multiple sclerosis (CDMS). Negative lesion activity in year 1 and slower central atrophy in year 2 were predictive of confirmed disability progression (9-Hole Peg Test). Positive lesion activity in year 2 was predictive of faster global atrophy, while positive lesion activity in years 1 and 2 was predictive of faster central atrophy. Conclusions: A higher degree of global atrophy and/or pseudo-atrophy in year 1 was predictive of CDMS. Positive lesion activity in any year was related to CDMS and neurodegeneration. Disability was related to negative lesion activity in year 1 and slower central atrophy in year 2. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Serum glial fibrillary acidic protein in natalizumab-treated relapsing-remitting multiple sclerosis: An alternative to neurofilament light

Author

Wessels, Mark HJ, primary, Van Lierop, Zoë YGJ, additional, Noteboom, Samantha, additional, Strijbis, Eva MM, additional, Heijst, Johannes A, additional, Van Kempen, Zoé LE, additional, Moraal, Bastiaan, additional, Barkhof, Frederik, additional, Uitdehaag, Bernard MJ, additional, Schoonheim, Menno M, additional, Killestein, Joep, additional, and Teunissen, Charlotte E, additional

Published
2023
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32. Diffusion-based structural connectivity patterns of multiple sclerosis phenotypes

Author

Martinez-Heras, Eloy, primary, Solana, Elisabeth, additional, Vivó, Francesc, additional, Lopez-Soley, Elisabet, additional, Calvi, Alberto, additional, Alba-Arbalat, Salut, additional, Schoonheim, Menno M, additional, Strijbis, Eva M, additional, Vrenken, Hugo, additional, Barkhof, Frederik, additional, Rocca, Maria A, additional, Filippi, Massimo, additional, Pagani, Elisabetta, additional, Groppa, Sergiu, additional, Fleischer, Vinzenz, additional, Dineen, Robert A, additional, Bellenberg, Barbara, additional, Lukas, Carsten, additional, Pareto, Deborah, additional, Rovira, Alex, additional, Sastre-Garriga, Jaume, additional, Collorone, Sara, additional, Prados, Ferran, additional, Toosy, Ahmed, additional, Ciccarelli, Olga, additional, Saiz, Albert, additional, Blanco, Yolanda, additional, and Llufriu, Sara, additional

Published
2023
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33. Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis

Author

Broos, Jelle Y., primary, Loonstra, Floor C., additional, de Ruiter, Lodewijk R.J., additional, Gouda, Mariam M.T.E.E., additional, Fung, Wing Hee, additional, Schoonheim, Menno M., additional, Heijink, Marieke, additional, Strijbis, Eva M.M., additional, Teunissen, Charlotte, additional, Killestein, Joep, additional, de Vries, Helga E., additional, Giera, Martin A., additional, Uitdehaag, Bernard M.J., additional, and Kooij, Gijs, additional

Published
2023
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34. Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis

Author

Broos, Jelle Y, Loonstra, Floor C, de Ruiter, Lodewijk R J, Gouda, Mariam M T E E, Fung, Wing Hee, Schoonheim, Menno M, Heijink, Marieke, Strijbis, Eva M M, Teunissen, Charlotte, Killestein, Joep, de Vries, Helga E, Giera, Martin A, Uitdehaag, Bernard M J, and Kooij, Gijs

Abstract

BACKGROUND AND OBJECTIVES: Excessive activation of certain lipid mediator (LM) pathways play a role in the complex pathogenesis of multiple sclerosis (MS). However, the relation between bioactive LMs and different aspects of CNS-related pathophysiological processes remains largely unknown. Therefore, we here assessed the association of bioactive LMs belonging to the ω-3 / ω-6 lipid classes with clinical, biochemical (serum neurofilament light (sNfL) and serum glial fibrillary acidic protein (sGFAP)) parameters and MRI-based brain volumes in patients with MS (PwMS) and healthy controls (HC).METHODS: A targeted high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) approach was used on plasma samples of PwMS and HC of the Project Y cohort, a cross-sectional population based cohort that contains PwMS all born in 1966 in the Netherlands and age-matched HCs. LMs were compared between PwMS and HC and were correlated with levels of sNfL, sGFAP, disability (EDSS) and brain volumes. Finally, significant correlates were included in a backward multivariate regression model to identify which LMs best related to disability.RESULTS: The study sample consisted of 170 patients with relapsing remitting MS (RRMS), 115 patients with progressive MS (PMS) and 125 HC. LM profiles of patients with PMS significantly differed from RRMS and HC, in particular, patients with PMS showed elevated levels of several arachidonic acid (AA) derivatives. In particular 15-HETE (r = 0.24, p < 0.001), positively correlated (average r = 0.2, p < 0.05) with clinical and biochemical parameters such as EDSS and sNfL. In addition, higher 15-HETE levels were related to lower total brain (r = -0.24, p = 0.04) and deep gray matter volumes (r = -0.27, p = 0.02) in patients with PMS and higher lesion volume (r = 0.15, p = 0.03) in all PwMS.DISCUSSION: In PwMS of the same birth year, we show that ω-3 and -6 LMs are associated with disability, biochemical (sNfL, GFAP) and MRI measures. Furthermore, our findings indicate that particularly in patients with PMS, elevated levels of specific products of the AA pathway, such as 15-HETE, associate with neurodegenerative processes. Our findings highlight the potential relevance of ω-6 LMs in the pathogenesis of MS.

Published
2023

39. Multicenter Evaluation of AI-generated DIR and PSIR for Cortical and Juxtacortical Multiple Sclerosis Lesion Detection

Author

Bouman, Piet M., primary, Noteboom, Samantha, additional, Nobrega Santos, Fernando A., additional, Beck, Erin S., additional, Bliault, Gregory, additional, Castellaro, Marco, additional, Calabrese, Massimiliano, additional, Chard, Declan T., additional, Eichinger, Paul, additional, Filippi, Massimo, additional, Inglese, Matilde, additional, Lapucci, Caterina, additional, Marciniak, Andrzej, additional, Moraal, Bastiaan, additional, Morales Pinzon, Alfredo, additional, Mühlau, Mark, additional, Preziosa, Paolo, additional, Reich, Daniel S., additional, Rocca, Maria A., additional, Schoonheim, Menno M., additional, Twisk, Jos W. R., additional, Wiestler, Benedict, additional, Jonkman, Laura E., additional, Guttmann, Charles R. G., additional, Geurts, Jeroen J. G., additional, and Steenwijk, Martijn D., additional

Published
2023
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41. Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis

Author

Cagol, Alessandro, Cortese, Rosa, Barakovic, Muhamed, Schaedelin, Sabine, Ruberte, Esther, Absinta, Martina, Barkhof, Frederik, Calabrese, Massimiliano, Castellaro, Marco, Ciccarelli, Olga, Cocozza, Sirio, De Stefano, Nicola, Enzinger, Christian, Filippi, Massimo, Jurynczyk, Maciej, Maggi, Pietro, Mahmoudi, Nima, Messina, Silvia, Montalban, Xavier, Palace, Jacqueline, Pontillo, Giuseppe, Pröbstel, Anne-Katrin, Rocca, Maria A., Ropele, Stefan, Rovira, Àlex, Schoonheim, Menno M., Sowa, Piotr, Strijbis, Eva, Wattjes, Mike P., Sormani, Maria Pia, Kappos, Ludwig, and Granziera, Cristina

Abstract

IMPORTANCE: Multiple sclerosis (MS) misdiagnosis remains an important issue in clinical practice. OBJECTIVE: To quantify the performance of cortical lesions (CLs) and central vein sign (CVS) in distinguishing MS from other conditions showing brain lesions on magnetic resonance imaging (MRI). DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective, cross-sectional multicenter study, with clinical and MRI data acquired between January 2010 and May 2020. Centralized MRI analysis was conducted between July 2020 and December 2022 by 2 raters blinded to participants’ diagnosis. Participants were recruited from 14 European centers and from a multicenter pan-European cohort. Eligible participants had a diagnosis of MS, clinically isolated syndrome (CIS), or non-MS conditions; availability of a brain 3-T MRI scan with at least 1 sequence suitable for CL and CVS assessment; presence of T2-hyperintense white matter lesions (WMLs). A total of 1051 individuals were included with either MS/CIS (n = 599; 386 [64.4%] female; mean [SD] age, 41.5 [12.3] years) or non-MS conditions (including other neuroinflammatory disorders, cerebrovascular disease, migraine, and incidental WMLs in healthy control individuals; n = 452; 302 [66.8%] female; mean [SD] age, 49.2 [14.5] years). Five individuals were excluded due to missing clinical or demographic information (n = 3) or unclear diagnosis (n = 2). EXPOSURES: MS/CIS vs non-MS conditions. MAIN OUTCOMES AND MEASURES: Area under the receiver operating characteristic curves (AUCs) were used to explore the diagnostic performance of CLs and the CVS in isolation and in combination; sensitivity, specificity, and accuracy were calculated for various cutoffs. The diagnostic importance of CLs and CVS compared to conventional MRI features (ie, presence of infratentorial, periventricular, and juxtacortical WMLs) was ranked with a random forest model. RESULTS: The presence of CLs and the previously proposed 40% CVS rule had a sensitivity, specificity, and accuracy for MS of 59.0% (95% CI, 55.1-62.8), 93.6% (95% CI, 91.4-95.6), and 73.9% (95% CI, 71.6-76.3) and 78.7% (95% CI, 75.5-82.0), 86.0% (95% CI, 82.1-89.5), and 81.5% (95% CI, 78.9-83.7), respectively. The diagnostic performance of the CVS (AUC, 0.89 [95% CI, 0.86-0.91]) was superior to that of CLs (AUC, 0.77 [95% CI, 0.75-0.80]; P &lt; .001), and was increased when combining the 2 imaging markers (AUC, 0.92 [95% CI, 0.90-0.94]; P = .04); in the random forest model, both CVS and CLs outperformed the presence of infratentorial, periventricular, and juxtacortical WMLs in supporting MS differential diagnosis. CONCLUSIONS AND RELEVANCE: The findings in this study suggest that CVS and CLs may be valuable tools to increase the accuracy of MS diagnosis.

Published
2024
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43. Using The Virtual Brain to study the relationship between structural and functional connectivity in patients with multiple sclerosis: a multicenter study

Author

Martí-Juan, Gerard, primary, Sastre-Garriga, Jaume, additional, Martinez-Heras, Eloy, additional, Vidal-Jordana, Angela, additional, Llufriu, Sara, additional, Groppa, Sergiu, additional, Gonzalez-Escamilla, Gabriel, additional, Rocca, Maria A, additional, Filippi, Massimo, additional, Høgestøl, Einar A, additional, Harbo, Hanne F, additional, Foster, Michael A, additional, Toosy, Ahmed T, additional, Schoonheim, Menno M, additional, Tewarie, Prejaas, additional, Pontillo, Giuseppe, additional, Petracca, Maria, additional, Rovira, Àlex, additional, Deco, Gustavo, additional, and Pareto, Deborah, additional

Published
2023
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45. Multimodal multilayer network centrality relates to executive functioning

Author

Breedt, Lucas C., primary, Santos, Fernando A. N., additional, Hillebrand, Arjan, additional, Reneman, Liesbeth, additional, van Rootselaar, Anne-Fleur, additional, Schoonheim, Menno M., additional, Stam, Cornelis J., additional, Ticheler, Anouk, additional, Tijms, Betty M., additional, Veltman, Dick J., additional, Vriend, Chris, additional, Wagenmakers, Margot J., additional, van Wingen, Guido A., additional, Geurts, Jeroen J. G., additional, Schrantee, Anouk, additional, and Douw, Linda, additional

Published
2023
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50. sj-pdf-5-msj-10.1177_13524585231159817 – Supplemental material for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis

Author

Simon, Shira, Nauta, Ilse M, Hillebrand, Arjan, Schoonheim, Menno M, Uitdehaag, Bernard MJ, van Dam, Maureen, Hulst, Hanneke E, Klein, Martin, Stam, Cornelis J, de Jong, Brigit A, and Strijbis, Eva MM

Subjects
FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-5-msj-10.1177_13524585231159817 for Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis by Shira Simon, Ilse M Nauta, Arjan Hillebrand, Menno M Schoonheim, Bernard MJ Uitdehaag, Maureen van Dam, Hanneke E Hulst, Martin Klein, Cornelis J Stam, Brigit A de Jong and Eva MM Strijbis in Multiple Sclerosis Journal

Published
2023
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