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5. ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Author

Weide Thomas, Hillmann Anja, Gauer Stefan, Altevogt Peter, Ludwig Andreas, Hauser Ingeborg A, Doberstein Kai, Abdel-Bakky Mohamed, Schramme Anja, Gutwein Paul, Jespersen Christine, Eberhardt Wolfgang, and Pfeilschifter Josef

Subjects
Medicine
Abstract

Abstract Background The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex. Methods By Western blot, immunofluorescence and immunohistochemistry analysis we characterized the expression of ADAM10 in human podocytes, human urine and human renal tissue. Results We present evidence, that differentiated human podocytes possessed increased amounts of mature ADAM10 and released elevated levels of L1 adhesion molecule, one well known substrate of ADAM10. By using specific siRNA and metalloproteinase inhibitors we demonstrate that ADAM10 is involved in the cleavage of L1 in human podocytes. Injury of podocytes enhanced the ADAM10 mediated cleavage of L1. In addition, we detected ADAM10 in urinary podocytes from patients with kidney diseases and in tissue sections of normal human kidney. Finally, we found elevated levels of ADAM10 in urinary vesicles of patients with glomerular kidney diseases. Conclusions The activity of ADAM10 in human podocytes may play an important role in the development of glomerular kidney diseases.

Published
2010
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8. Residual tumor cells are unique cellular targets in glioblastoma

Author

Glas, Martin, primary, Rath, Barbara H., additional, Simon, Matthias, additional, Reinartz, Roman, additional, Schramme, Anja, additional, Trageser, Daniel, additional, Eisenreich, Ramona, additional, Leinhaas, Anke, additional, Keller, Mihaela, additional, Schildhaus, Hans-Ulrich, additional, Garbe, Stephan, additional, Steinfarz, Barbara, additional, Pietsch, Torsten, additional, Steindler, Dennis A., additional, Schramm, Johannes, additional, Herrlinger, Ulrich, additional, Brüstle, Oliver, additional, and Scheffler, Björn, additional

Published
2010
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9. ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma

Author

Lee, Sophia B., primary, Schramme, Anja, additional, Doberstein, Kai, additional, Dummer, Reinhard, additional, Abdel-Bakky, Mohamed S., additional, Keller, Sascha, additional, Altevogt, Peter, additional, Oh, Shin T., additional, Reichrath, Jörg, additional, Oxmann, Daniel, additional, Pfeilschifter, Josef, additional, Mihic-Probst, Daniela, additional, and Gutwein, Paul, additional

Published
2010
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10. ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Author

Gutwein, Paul, primary, Schramme, Anja, additional, Abdel-Bakky, Mohamed, additional, Doberstein, Kai, additional, Hauser, Ingeborg A, additional, Ludwig, Andreas, additional, Altevogt, Peter, additional, Gauer, Stefan, additional, Hillmann, Anja, additional, Weide, Thomas, additional, Jespersen, Christine, additional, Eberhardt, Wolfgang, additional, and Pfeilschifter, Josef, additional

Published
2010
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11. CXCL16 and oxLDL are induced in the onset of diabetic nephropathy

Author

Gutwein, Paul, primary, Abdel‐Bakky, Mohamed Sadek, additional, Doberstein, Kai, additional, Schramme, Anja, additional, Beckmann, Janet, additional, Schaefer, Liliana, additional, Amann, Kerstin, additional, Doller, Anke, additional, Kämpfer‐Kolb, Nicole, additional, Abdel‐Aziz, Abdel‐Aziz H., additional, Sayed, El Sayed M. El, additional, and Pfeilschifter, Josef, additional

Published
2009
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12. CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein

Author

Gutwein, Paul, primary, Abdel-Bakky, Mohamed Sadek, additional, Schramme, Anja, additional, Doberstein, Kai, additional, Kämpfer-Kolb, Nicole, additional, Amann, Kerstin, additional, Hauser, Ingeborg A., additional, Obermüller, Nicholas, additional, Bartel, Christine, additional, Abdel-Aziz, Abdel-Aziz H., additional, El Sayed, El Sayed M., additional, and Pfeilschifter, Josef, additional

Published
2009
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13. Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma

Author

Gutwein, Paul, primary, Schramme, Anja, additional, Voss, Beren, additional, Abdel-Bakky, Mohamed Sadek, additional, Doberstein, Kai, additional, Ludwig, Andreas, additional, Altevogt, Peter, additional, Hansmann, Martin-Leo, additional, Moch, Holger, additional, Kristiansen, Glen, additional, and Pfeilschifter, Josef, additional

Published
2009
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15. Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients

Author

Gutwein, Paul, primary, Schramme, Anja, additional, Sinke, Nina, additional, Abdel-Bakky, Mohamed Sadek, additional, Voss, Beren, additional, Obermüller, Nicholas, additional, Doberstein, Kai, additional, Koziolek, Michael, additional, Fritzsche, Florian, additional, Johannsen, Manfred, additional, Jung, Klaus, additional, Schaider, Helmut, additional, Altevogt, Peter, additional, Ludwig, Andreas, additional, Pfeilschifter, Josef, additional, and Kristiansen, Glen, additional

Published
2009
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17. Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

Author

Schramme, Anja, primary, Abdel-Bakky, Mohamed Sadek, additional, Gutwein, Paul, additional, Obermüller, Nicholas, additional, Baer, Patrick C., additional, Hauser, Ingeborg A., additional, Ludwig, Andreas, additional, Gauer, Stefan, additional, Schäfer, Liliana, additional, Sobkowiak, Ewelina, additional, Altevogt, Peter, additional, Koziolek, Michael, additional, Kiss, Eva, additional, Gröne, Hermann-Josef, additional, Tikkanen, Ritva, additional, Goren, Itamar, additional, Radeke, Heinfried, additional, and Pfeilschifter, Josef, additional

Published
2008
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19. Intraperitoneal dissemination of Ad12-induced undifferentiated neuroectodermal hamster tumors: de novo methylation and transcription patterns of integrated viral and of cellular genes

Author

Hohlweg, Urte, primary, Hösel, Marianna, additional, Dorn, Andreas, additional, Webb, Dennis, additional, Hilger-Eversheim, Kristina, additional, Remus, Ralph, additional, Schmitz, Birgit, additional, Buettner, Reinhold, additional, Schramme, Anja, additional, Corzilius, Lars, additional, Niemann, Anke, additional, and Doerfler, Walter, additional

Published
2003
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20. Oncogenic Signaling Pathways and Deregulated Target Genes.

Author

Schlag, P. M., Senn, H. -J., Kleihues, P., Stiefel, F., Groner, B., Wallgren, A., Rentchnik, P., Dietel, Manfred, Kreipe, Hans H., von Wasielewski, Reinhard, Schramme, Anja, Tchernitsa, Oleg I., and Sers, Christine

Abstract

A limited number of somatic mutations are known to trigger malignancy via chronic activation of cellular signaling pathways. High-throughput analysis of gene expression in cancer cells has revealed a plethora of deregulated genes by far exceeding the number of known genetic alterations. Targeted tumor therapy takes advantage of deregulated signaling in cancer. However, cancer cells may evade successful therapy, e.g., targeting oncogenic kinases, due to mutation of the target protein or to resistance mechanisms acting downstream of or parallel to the therapeutic block. To improve therapy and molecular diagnostics, we need detailed information on the wiring of pathway components and targets that ultimately execute the malignant properties of advanced tumors. Here we review work on Ras-mediated signal transduction and Ras pathway- responsive targets. We introduce the concept of signal-regulated transcriptional modules comprising groups of target genes responding to individual branches of the pathway network. Furthermore, we discuss functional approaches based on RNA interference for elucidating critical nodes in oncogenic signaling and the targets essential for malignancy. [ABSTRACT FROM AUTHOR]

Published
2007
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