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217 results on '"Schubert, Timm"'

19. A retinal model of cerebral malaria

Author

Paquet-Durand, François, Beck, Susanne C., Das, Soumyaparna, Huber, Gesine, Le Chang, Schubert, Timm, Tanimoto, Naoyuki, Garcia-Garrido, Marina, Mühlfriedel, Regine, Bolz, Sylvia, Hoffmann, Wolfgang, Schraermeyer, Ulrich, Mordmüller, Benjamin, and Seeliger, Mathias W.

Published
2019
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20. Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.

Author

Le Chang, Yanli Ran, Mingpo Yang, Auferkorte, Olivia, Butz, Elisabeth, Hüser, Laura, Haverkamp, Silke, Euler, Thomas, and Schubert, Timm

Subjects
ION channels, RETINAL ganglion cells, ACTIVATION energy, RETINA, ACTION potentials, SODIUM channels, MARKETING channels
Abstract

In the vertebrate retina, several dozens of parallel channels relay information about the visual world to the brain. These channels are represented by the different types of retinal ganglion cells (RGCs), whose responses are rendered selective for distinct sets of visual features by various mechanisms. These mechanisms can be roughly grouped into synaptic interactions and cell-intrinsic mechanisms, with the latter including dendritic morphology as well as ion channel complement and distribution. Here, we investigate how strongly ion channel complement can shape RGC output by comparing two mouse RGC types, the well-described ON alpha cell and a little-studied ON cell that is EGFP-labelled in the Igfbp5 mouse line and displays an unusual selectivity for stimuli with high contrast. Using patch-clamp recordings and computational modelling, we show that a higher activation threshold and a pronounced slow inactivation of the voltage-gated Na+ channels contribute to the distinct contrast tuning and transient responses in ON Igfbp5 RGCs, respectively. In contrast, such a mechanism could not be observed in ON alpha cells. This study provides an example for the powerful role that the last stage of retinal processing can play in shaping RGC responses. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype

Author

Schubert, Timm, Gleiser, Corinna, Heiduschka, Peter, Franz, Christoph, Nagel-Wolfrum, Kerstin, Sahaboglu, Ayse, Weisschuh, Nicole, Eske, Gordon, Rohbock, Karin, Rieger, Norman, Paquet-Durand, François, Wissinger, Bernd, Wolfrum, Uwe, Hirt, Bernhard, Singer, Wibke, Rüttiger, Lukas, Zimmermann, Ulrike, and Knipper, Marlies

Published
2015
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47. Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling

Author

Behrens, Christian, primary, Zhang, Yue, additional, Yadav, Shubhash Chandra, additional, Haverkamp, Silke, additional, Irsen, Stephan, additional, Korympidou, Maria M., additional, Schaedler, Anna, additional, Dedek, Karin, additional, Smith, Robert G., additional, Euler, Thomas, additional, Berens, Philipp, additional, and Schubert, Timm, additional

Published
2019
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49. The temporal structure of the inner retina at a single glance

Author

Zhao, Zhijian, primary, Klindt, David, additional, Chagas, André Maia, additional, Szatko, Klaudia P., additional, Rogerson, Luke, additional, Protti, Dario A., additional, Behrens, Christian, additional, Dalkara, Deniz, additional, Schubert, Timm, additional, Bethge, Matthias, additional, Franke, Katrin, additional, Berens, Philipp, additional, Ecker, Alexander, additional, and Euler, Thomas, additional

Published
2019
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50. Assembly of the outer retina in the absence of GABA synthesis in horizontal cells

Author

Parker Edward, Huckfeldt Rachel M, Schubert Timm, Campbell John E, and Wong Rachel OL

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background The inhibitory neurotransmitter gamma-amino-butyric acid (GABA) not only modulates excitability in the mature nervous system but also regulates neuronal differentiation and circuit development. Horizontal cells, a subset of interneurons in the outer retina, are transiently GABAergic during the period of cone photoreceptor synaptogenesis. In rodents, both horizontal cells and cone axonal terminals express GABAA receptors. To explore the possibility that transient GABA expression in mouse neonatal horizontal cells influences the structural development of synaptic connectivity in the outer retina, we examined a mutant in which expression of GAD67, the major synthesizing enzyme for GABA, is selectively knocked out in the retina. Results Immunocytochemistry and electron microscopy revealed that the assembly of triad synapses involving cone axonal pedicles and the dendrites of horizontal and bipolar cells is unaffected in the mutant retina. Moreover, loss of GABA synthesis in the outer retina did not perturb the spatial distributions and cell densities of cones and horizontal cells. However, there were some structural alterations at the cellular level: the average size of horizontal cell dendritic clusters was larger in the mutant, and there was also a small but significant increase in cone photoreceptor pedicle area. Moreover, metabotropic glutamate receptor 6 (mGluR6) receptors on the dendrites of ON bipolar cells occupied a slightly larger proportion of the cone pedicle in the mutant. Conclusions Together, our analysis shows that transient GABA synthesis in horizontal cells is not critical for synapse assembly and axonal and dendritic lamination in the outer retina. However, pre- and postsynaptic structures are somewhat enlarged in the absence of GABA in the developing outer retina, providing for a modest increase in potential contact area between cone photoreceptors and their targets. These findings differ from previous results in which pharmacological blockade of GABAA receptors in the neonatal rabbit retina caused a reduction in cone numbers and led to a grossly disorganized outer retina.

Published
2010
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