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16 results on '"Schuhmann M.U."'

3. MR Imaging and Clinical Characteristics of Diffuse Glioneuronal Tumor with Oligodendroglioma-like Features and Nuclear Clusters

Author

Benesch, M., primary, Perwein, T., additional, Apfaltrer, G., additional, Langer, T., additional, Neumann, A., additional, Brecht, I.B., additional, Schuhmann, M.U., additional, Cario, H., additional, Frühwald, M.C., additional, Vollert, K., additional, van Buiren, M., additional, Deng, M.Y., additional, Seitz, A., additional, Haberler, C., additional, Mynarek, M., additional, Kramm, C., additional, Sahm, F., additional, Robe, P.A., additional, Dankbaar, J.W., additional, Hoff, K.V., additional, Warmuth-Metz, M., additional, and Bison, B., additional

Published
2022
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4. Near-infrared spectroscopy for perioperative assessment and neonatal interventions.

Author

Pellicer A., Neunhoeffer F., Schuhmann M.U., Breindahl M., Fumagelli M., Mintzer J., de Boode W., Alarcon A., Alderliesten T., Austin T., Bruckner M., de Boode W.P., Dempsey G., Ergenekon E., Fumagalli M., Greisen G., Gucuyener K., Hahn G.H., Kalish B.T., Kooi E., Lee-Summers J., Lemmers P., Levy P.T., Liem K.D., Hansen M.L., Martini S., Naulaers G., Pichler G., Rhee C., Roehr C.C., Roll C., Schwarz C.E., da Costa C.S., Szczapa T., Urlesberger B., Wolf M., Wong F., Pellicer A., Neunhoeffer F., Schuhmann M.U., Breindahl M., Fumagelli M., Mintzer J., de Boode W., Alarcon A., Alderliesten T., Austin T., Bruckner M., de Boode W.P., Dempsey G., Ergenekon E., Fumagalli M., Greisen G., Gucuyener K., Hahn G.H., Kalish B.T., Kooi E., Lee-Summers J., Lemmers P., Levy P.T., Liem K.D., Hansen M.L., Martini S., Naulaers G., Pichler G., Rhee C., Roehr C.C., Roll C., Schwarz C.E., da Costa C.S., Szczapa T., Urlesberger B., Wolf M., and Wong F.

Abstract

Perioperative applications of near-infrared spectroscopy (NIRS) to monitor regional tissue oxygenation and perfusion in cardiac and noncardiac surgery are of increasing interest in neonatal care. Complex neonatal surgery can impair adequate oxygen delivery and tissue oxygen consumption and increase the risk of neurodevelopmental delay. Coupled with conventional techniques, NIRS monitoring may enable targeted hemodynamic management of the circulation in both cardiac and noncardiac surgical procedures. In this narrative review, we discuss the application of perioperative NIRS in specific neonatal interventions, including surgical intervention for congenital heart defects, definitive closure of the patent ductus arteriosus, neurological and gastrointestinal disorders, and use of extracorporeal membrane oxygenation. We identified areas for future research within disease-specific indications and offer a roadmap to aid in developing evidence-based targeted diagnostic and management strategies in neonates. Impact: There is growing recognition that perioperative NIRS monitoring, used in conjunction with conventional monitoring, may provide critical hemodynamic information that either complements clinical impressions or delivers novel physiologic insight into the neonatal circulatory and perfusion pathways.Copyright © 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

Published
2021

5. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Author

Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., et al., Sturm, D., Orr, B.A., Toprak, U.H., Hovestadt, V., Jones, D.T., Capper, D., Sill, M., Buchhalter, I., Northcott, P.A., Leis, I., Ryzhova, M., Koelsche, C., Pfaff, E., Allen, S.J., Balasubramanian, G., Worst, B.C., Pajtler, K.W., Brabetz, S., Johann, P.D., Sahm, F., Reimand, J., Mackay, A., Carvalho, D.M., Remke, M., Phillips, J.J., Perry, A., Cowdrey, C., Drissi, R., Fouladi, M., Giangaspero, F., Lastowska, M., Grajkowska, W., Scheurlen, W., Pietsch, T., Hagel, C., Gojo, J., Lotsch, D., Berger, W., Slavc, I., Haberler, C., Jouvet, A., Holm, S., Hofer, S., Prinz, M., Keohane, C., Fried, I., Mawrin, C., Scheie, D., Mobley, B.C., Schniederjan, M.J., Santi, M., Buccoliero, A.M., Dahiya, S., Kramm, C.M., Bueren, A.O. von, Hoff, K. von, Rutkowski, S., Herold-Mende, C., Fruhwald, M.C., Milde, T., Hasselblatt, M., Wesseling, P., Rossler, J., Schuller, U., Ebinger, M., Schittenhelm, J., Frank, S., Grobholz, R., Vajtai, I., Hans, V., Schneppenheim, R., Zitterbart, K., Collins, V.P., Aronica, E., Varlet, P., Puget, S., Dufour, C., Grill, J., Figarella-Branger, D., Wolter, M., Schuhmann, M.U., Shalaby, T., Grotzer, M., Meter, T. van, Monoranu, C.M., Felsberg, J., Reifenberger, G., Snuderl, M., Forrester, L.A., Koster, J., Versteeg, R., Volckmann, R., Sluis, P. van, Wolf, S., Mikkelsen, T., Gajjar, A., Aldape, K., Moore, A.S., Taylor, M.D., Jones, C., and et al.

Abstract

Item does not contain fulltext, Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

6. Outcome analysis of the randomized multi-center study on idiophatic normal pressure hydrocephalus (SVASONA)

Author

Lemcke, J., Meier, U., Müller, C., Fritsch, M., Kehler, U., Langer, N., Kiefer, M., Eymann, R., Schuhmann, M.U., Speil, A., Weber, F., Remenez, V., Rohde, V., Ludwig, H.C., and Stengel, D.

Subjects
ddc: 610, randomized, SVASONA, randomisiert, 610 Medical sciences, Medicine, prospective, nervous system diseases, prospektiv
Abstract

Objective: The Dutch hydrocephalus study in the 1990s proved the superiority of LPVs in the therapy of the idiopathic normal pressure hydrocephalus and simultaneously uncovered the enormous risk of overdrainage complications for the use of low pressure valves without a gravitational compensation. The[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012
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7. The venous pathophysiology of chronic overdrainage syndrome

Author

Schuhmann, M.U., Sosa, J., Ebner, F.H., Skardelly, M., and Speil, A.

Subjects
ddc: 610, chronic overdrainage, chronische Überdrainage, Slit ventricel Sydnrome, 610 Medical sciences, Medicine, hydrocephalus, Schlitzventirkelsyndrom
Abstract

Objective: The pathophysiology of chronic overdrainage syndrome (COS), or slit ventricle syndrome, is still not universally known or accepted. A venous pathophysiology has been proposed by Sood et al in 2004. We present an educative case-based update highlighting the intracranial dynamics of COS and[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Published
2012
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12. O.103 Protocol for the randomized controlled SVASONA trial (ISRCTN51046698): Shunt valves plus shunt assistant versus shunt valves alone for controlling overdrainage in idiopathic normal-pressure hydrocephalus in adults

Author

Lemcke, J., primary, Meier, U., additional, Müller, C., additional, Fritsch, M., additional, Kiefer, M., additional, Eymann, R., additional, Kehler, U., additional, Langer, N., additional, Rohde, V., additional, Ludwig, H.C., additional, Weber, F., additional, Remenez, V., additional, Schuhmann, M.U., additional, and Stengel, D., additional

Published
2008
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15. Acute care in neurosurgery: quantity, quality, and challenges

Author

Schuhmann, M.U., Rickels, E., Rosahl, S.K., Schneekloth, C.G., and Samii, M.

Abstract

OBJECTIVE: Part of the daily routine in neurosurgery is the treatment of emergency room admissions, and acute cases from other departments or from outside hospitals. This acute care is not normally included in performance figures or budget management, nor analysed scientifically in respect of quantity and quality of care provided by neurosurgeons. METHOD: Over a 1 year period, all acute care cases managed by two neurosurgical on call teams in a large northern German city, were recorded prospectively on a day by day basis. A large database of 1819 entries was created and analysed using descriptive statistics. RESULTS: The minimum incidence of patients requiring neurosurgical acute care was estimated to be 75-115/100 000 inhabitants/year. This corresponds to a mean of about 6/day. Only 30% of patients came directly via the emergency room. The fate of 70% of patients depended initially on the "neurosurgical qualification" of primary care doctors and here deficits existed. Although most intracerebral and subarachnoid haemorrhages were managed with the participation of neurosurgeons, they were not involved in the management of most mild and moderate traumatic brain injuries. Within 1 year the additional workload from acute care amounted to 1000 unplanned admissions, 900 acute imaging procedures, and almost 400 emergency operations. CONCLUSION: The current policy in public health, which includes cuts in resources, transport facilities, and manpower, is not compatible with the demonstrated extent of acute neurosurgical care. In addition to routine elective work, many extra admissions, evening or night time surgery, and imaging procedures have to be accomplished. An education programme for generalists is required to improve overall patient outcome. These conclusions hold special importance if health authorities wish to not only maintain present standards but aim to improve existing deficits.

Published
2001

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