141 results on '"Schuler, Maik"'
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2. A Kinetic Model for Assessing Potential Nitrosamine Carcinogenicity.
3. Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment
4. An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis
5. Comparative analysis of micronucleus induction and DNA damage biomarkers in TK6 and A375 cells using flow cytometry.
6. A New Imaging Platform (iScreen) Allows for the Concurrent Assessment of Micronucleus Induction and Genotoxic Mode of Action in Human A375 Cells
7. Development and validation of an in vitro micronucleus assay platform in TK6 cells
8. Development challenges for carcinogenicity risk assessments of topical drugs
9. Effects of Estrogens on Microtubule Assembly: Significance for Aneuploidy
10. Induction of Micronucleation, Spindle Disturbances, and Mitotic Arrest in Human Chorionic Villi Cells by 17ß-Estradiol, Diethylstilbestrol, and Coumestrol
11. Defining EMS and ENU dose–response relationships using the Pig-a mutation assay in rats
12. Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)
13. Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing
14. Evaluation of a modified CD71 MicroFlow ® method for the flow cytometric analysis of micronuclei in rat bone marrow erythrocytes
15. Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells
16. Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents
17. Evaluation of the Pig-a, Micronucleus, and Comet Assay Endpoints in a 28-Day Study With Ethyl Methanesulfonate
18. Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds
19. Phenolphthalein Induces Centrosome Amplification And Tubulin Depolymerization In Vitro
20. Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea – comparison with other in vivo genotoxicity endpoints
21. Need and potential value of the Pig-a in vivo mutation assay—A hesi perspective
22. The rat gut micronucleus assay: A good choice for alternative in vivo genetic toxicology testing strategies
23. Follow-up actions from positive results of in vitro genetic toxicity testing
24. Chemically induced aneuploidy in germ cells. Part II of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
25. High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT)
26. Targets and mechanisms of chemically induced aneuploidy. Part 1 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
27. Role of aneuploidy in the carcinogenic process: Part 3 of the report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases
28. Application of the adverse outcome pathway framework to genotoxic modes of action
29. Concordance Analysis of an In Vitro Micronucleus Screening Assay and the Regulatory Chromosome Aberration Assay Using Pharmaceutical Drug Candidates
30. Improving Dose Selection and Identification of Aneugens in the In Vitro Chromosome Aberration Test by Integration of Flow Cytometry-Based Methods
31. Analysis of historical negative control group data from the in vitro micronucleus assay using human lymphocytes
32. Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells
33. Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay
34. IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk
35. IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)
36. Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay
37. Synthesis, Molecular Editing, and Biological Assessment of the Potent Cytotoxin Leiodermatolide
38. Evaluation of thePig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate
39. Multicolor FISH using tándem probes to detect Chromosome alterations in humans cells and populations exposed to genotoxic agents
40. Impact of cell cycle delay on micronucleus frequency in TK6 cells
41. Need and potential value of the Pig-ain vivo mutation assay-A hesi perspective
42. Evaluation of a modified CD71 MicroFlow® method for the flow cytometric analysis of micronuclei in rat bone marrow erythrocytes
43. Follow-up actions from positive results of in vitro genetic toxicity testing
44. The rat gut micronucleus assay: A good choice for alternative in vivo genetic toxicology testing strategies
45. Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates
46. Impact of cell cycle delay on micronucleus frequency in TK6 cells.
47. P XIV C.23 Detection of cytogenetic damages in blood cells of benzene-exposed workers by multicolor fluorescence in situ hybridization (FISH)
48. P XIV C.11 Characterization of chromosomal alterations occurring in B6C3F1 mice following benzene exposure using fluorescence in situ hybridization (FISH)
49. Detection of chromosomal breakage in the 1Q12, 9Q12, and 16Q11.2 regions induced by melphalan in cultured human lymphocytes using multicolor fluorescence in situ hybridization
50. Effects of novel 3,4-bisphenylhex(3)enes on cell proliferation in malignant and normal cells
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