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261 results on '"Schuler-Faccini, Lavínia"'

1. Epidemiological surveillance in congenital anomalies and rare diseases in Brazil: present situation and future challenges

Author

Schuler-Faccini, Lavínia, de Menezes Karam, Simone, Vieira Sanseverino, Maria Teresa, Barbian, Marcia Helena, Gomes, Julia do Amaral, Bremm, João Matheus, Cardoso-dos-Santos, Augusto César, Lorea, Claudia Fernandes, Donis, Karina Carvalho, Rohweder, Ricardo, Cardoso-Junior, Laércio Moreira, do Carmo, Julia Cavalcante, Corecco-Moura, Paulyana dos Santos, de Oliveira, Fabyanne Guimarães, de Oliveira, Rayhele Rodrigues, Prazeres, Vânia Mesquita Gadelha, da Silva, Juliana Herrero, Muniz, Nitza Ferreira, Babalola, Ayoade Desmond, Krieck, Laysa Kariny, de Souza, Angel Larroza, Ataíde, Emilly de Jesus Garcia, Oliveira, Lucia Andreia Nunes de, and França, Giovanny Vinícius de Araújo

Published
2025
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3. Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series

Author

das Neves Martins, Fernanda Eduarda, Chiang, Jannifer Oliveira, Nunes, Bruno Tardelli Diniz, Ribeiro, Bethania de Freitas Rodrigues, Martins, Lívia Carício, Casseb, Lívia Medeiros Neves, Henriques, Daniele Freitas, de Oliveira, Consuelo Silva, Maciel, Ethel Leonor Noia, Azevedo, Rafael da Silva, Cravo, Layna de Cássia Campos, Barreto, André Rodrigues Façanha, Pessoa, André Luiz Santos, Filho, Arnaldo Jorge Martins, de Sousa, Jorge Rodrigues, Schuler-Faccini, Lavinia, Quaresma, Juarez Antônio Simões, da Costa Vasconcelos, Pedro Fernando, and da Silva Azevedo, Raimunda do Socorro

Published
2025
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4. Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

Author

Schuler-Faccini, Lavínia, del Campo, Miguel, García-Alix, Alfredo, Ventura, Liana O, Boquett, Juliano André, van der Linden, Vanessa, Pessoa, André, van der Linden Júnior, Hélio, Ventura, Camila V, Leal, Mariana Carvalho, Kowalski, Thayne Woycinck, Gerzson, Lais Rodrigues, de Almeida, Carla Skilhan, Santi, Lucélia, Beys-da-Silva, Walter O, Quincozes-Santos, André, Guimarães, Jorge A, Garcez, Patricia P, do Amaral Gomes, Julia, Vianna, Fernanda Sales Luiz, da Silva, André Anjos, Fraga, Lucas Rosa, Sanseverino, Maria Teresa Vieira, Muotri, Alysson R, da Rosa, Rafael Lopes, Abeche, Alberto Mantovani, Marcolongo-Pereira, Clairton, and Souza, Diogo O

Subjects
Biological Sciences, Genetics, Clinical Research, Neurosciences, Pediatric, Brain Disorders, Basic Behavioral and Social Science, Perinatal Period - Conditions Originating in Perinatal Period, Behavioral and Social Science, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Neurological, Mental health, Good Health and Well Being, microcephaly, zika, epilepsy, cerebral palsy, neurodevelopement, eye, Clinical Sciences, Law
Abstract

Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.

Published
2022

5. Caffeine intake during pregnancy and adverse outcomes: An integrative review

Author

Rohweder, Ricardo, de Oliveira Schmalfuss, Thanyse, dos Santos Borniger, Diessy, Ferreira, Carolina Zanfir, Zanardini, Marcos Kobren, Lopes, Guilherme Paulon Torrano Ferreira, Barbosa, Camila Pocharski, Moreira, Taiane Dornelles, Schuler-Faccini, Lavinia, Sanseverino, Maria Teresa Vieira, da Silva, André Anjos, Abeche, Alberto Mantovani, Vianna, Fernanda Sales Luiz, and Fraga, Lucas Rosa

Published
2024
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7. Heart rate variability monitoring identifies asymptomatic toddlers exposed to Zika virus during pregnancy

Author

Herry, Christophe L., Soares, Helena M. F., Schuler-Faccini, Lavinia, and Frasch, Martin G.

Subjects
Quantitative Biology - Quantitative Methods, Quantitative Biology - Tissues and Organs
Abstract

Although Zika virus (ZIKV) seems to be prominently neurotropic, there are some reports of involvement of other organs, particularly the heart. Of special concern are those children exposed prenatally to ZIKV and born with no microcephaly or other congenital anomaly. Electrocardiogram (ECG) - derived heart rate variability (HRV) metrics represent an attractive, low cost, widely deployable tool for early identification of such children. We hypothesized that HRV in such children would yield a biomarker of fetal ZIKV exposure. We investigated the HRV properties of 21 infants aged 4 to 25 months from Brazil. The infants were divided in two groups, the ZIKV-exposed (n=13) and controls (n=8). Single channel ECG was recorded in each child at ~15 months of age and HRV was analyzed in 5 min segments to provide a comprehensive characterization of the degree of variability and complexity of the heart rate. Using a cubic Support Vector Machine (SVM) classifier we identified babies as Zika cases or controls with negative predictive value of 92% and positive predictive value of 86%. Our results show that HRV metrics can help differentiate between ZIKV-affected, yet asymptomatic, and non-ZIKV exposed babies. We identified the Grid Count as the best HRV measure in this study allowing such differentiation, regardless the presence of microcephaly. We show that it is feasible to measure HRV in infants and toddlers using a small non-invasive portable ECG device and that such approach may uncover memory of in utero exposure to ZIKV. This approach may be useful for future studies and low-cost screening tools involving this challenging to examine population.

Published
2018
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8. Bioinformatic Multi-Strategy Profiling of Congenital Heart Defects for Molecular Mechanism Recognition.

Author

de Oliveira, Fabyanne Guimarães, Foletto, João Vitor Pacheco, Medeiros, Yasmin Chaves Scimczak, Schuler-Faccini, Lavínia, and Kowalski, Thayne Woycinck

Subjects
HYPOPLASTIC left heart syndrome, CONGENITAL heart disease, MOLECULAR recognition, GENE expression, SYSTEMS biology
Abstract

Congenital heart defects (CHDs) rank among the most common birth defects, presenting diverse phenotypes. Genetic and environmental factors are critical in molding the process of cardiogenesis. However, these factors' interactions are not fully comprehended. Hence, this study aimed to identify and characterize differentially expressed genes involved in CHD development through bioinformatics pipelines. We analyzed experimental datasets available in genomic databases, using transcriptome, gene enrichment, and systems biology strategies. Network analysis based on genetic and phenotypic ontologies revealed that EP300, CALM3, and EGFR genes facilitate rapid information flow, while NOTCH1, TNNI3, and SMAD4 genes are significant mediators within the network. Differential gene expression (DGE) analysis identified 2513 genes across three study types, (1) Tetralogy of Fallot (ToF); (2) Hypoplastic Left Heart Syndrome (HLHS); and (3) Trisomy 21/CHD, with LYVE1, PLA2G2A, and SDR42E1 genes found in three of the six studies. Interaction networks between genes from ontology searches and the DGE analysis were evaluated, revealing interactions in ToF and HLHS groups, but none in Trisomy 21/CHD. Through enrichment analysis, we identified immune response and energy generation as some of the relevant ontologies. This integrative approach revealed genes not previously associated with CHD, along with their interactions and underlying biological processes. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Exploring the relationship between genetic instability and health outcomes in acute and chronic post-COVID syndrome.

Author

Martins, Bruna Alves Alonso, Garcia, Ana Leticia Hilario, Borges, Malu Siqueira, Picinini, Juliana, Serpa, Enaile Tuliczewski, Nobles, Daiane Dias Ribeiro, Silva, Luana Letícia, Dalberto, Daiana, Hansen, Alana Witt, Spilki, Fernando Rosado, Schuler-Faccini, Lavínia, Rampelotto, Pabulo Henrique, and Silva, Juliana Da

Subjects
POST-acute COVID-19 syndrome, MULTIPLE regression analysis, DNA damage, GENETIC markers, COVID-19
Abstract

The COVID-19 pandemic has led to the emergence of acute and chronic post-COVID syndromes, which present diverse clinical manifestations. The underlying pathophysiology of these conditions is not yet fully understood, but genetic instability has been proposed as a potential contributing factor. This study aimed to explore the differential impact of physical and psychological health factors on genetic instability in individuals with acute and chronic post-COVID syndromes. In this study, three groups of subjects were analyzed: a control group, an acute post-COVID group, and a chronic post-COVID group, with a total of 231 participants. The participants were assessed using a questionnaire for long-COVID-19COVID, and female participants reported more symptoms than male participants in areas related to fatigue, memory, mental health, and well-being during the chronic phase. Genetic instability was assessed using the comet assay, and participants' physical and psychological profiles were evaluated. The overall results showed no significant differences in DNA damage, as measured by the comet assay, among the three groups, suggesting that genetic instability, as assessed by this method, may not be a primary driver of the distinct clinical presentations observed in post-COVID syndromes. However, when gender was considered, male participants in the acute long COVID group exhibited higher levels of genetic instability compared to females. Multiple linear regression analysis revealed that gender, age, and waist circumference were significant predictors of DNA damage. Among females in the acute group, sexual health, and eye-related symptoms significantly influenced the increase in DNA damage. These findings indicate the need for further investigation on the gender-specific differences in genetic instability and their potential implications for the pathophysiology of post-COVID syndromes. Exploring alternative markers of genetic instability and the interplay between genetic, inflammatory, and cellular processes could provide valuable insights for the management of these debilitating post-viral sequelae. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: A nationwide record linkage study

Author

Costa, Maria da Conceição N., Cardim, Luciana Lobato, Moore, Cynthia A., de Jesus, Eliene dos Santos, Carvalho-Sauer, Rita, Barreto, Mauricio L., Rodrigues, Laura C., Smeeth, Liam, Schuler-Faccini, Lavínia, Brickley, Elizabeth B., Oliveira, Wanderson K., Carmo, Eduardo Hage, Pescarini, Julia Moreira, Andrade, Roberto F. S., Rodrigues, Moreno M. S., Veiga, Rafael V., Costa, Larissa C., França, Giovanny V. A., Teixeira, Maria Gloria, and Paixão, Enny S.

Subjects
Statistics, Complications and side effects, Patient outcomes, Pediatric research, Pediatric communicable diseases -- Statistics -- Complications and side effects -- Patient outcomes, Perinatal infection -- Statistics -- Patient outcomes -- Complications and side effects, Zika virus infection -- Statistics -- Patient outcomes -- Complications and side effects, Communicable diseases in children -- Statistics -- Complications and side effects -- Patient outcomes
Abstract

Author(s): Maria da Conceição N. Costa 1,2, Luciana Lobato Cardim 1, Cynthia A. Moore 3, Eliene dos Santos de Jesus 2,4, Rita Carvalho-Sauer 2,5, Mauricio L. Barreto 1,2, Laura C. [...], Background Children with congenital Zika syndrome (CZS) have severe damage to the peripheral and central nervous system (CNS), greatly increasing the risk of death. However, there is no information on the sequence of the underlying, intermediate, immediate, and contributing causes of deaths among these children. The aims of this study are describe the sequence of events leading to death of children with CZS up to 36 months of age and their probability of dying from a given cause, 2015 to 2018. Methods and findings In a population-based study, we linked administrative data on live births, deaths, and cases of children with CZS from the SINASC (Live Birth Information System), the SIM (Mortality Information System), and the RESP (Public Health Event Records), respectively. Confirmed and probable cases of CZS were those that met the criteria established by the Brazilian Ministry of Health. The information on causes of death was collected from death certificates (DCs) using the World Health Organization (WHO) DC template. We estimated proportional mortality (PM%) among children with CZS and among children with non-Zika CNS congenital anomalies (CA) by 36 months of age and proportional mortality ratio by cause (PMRc). A total of 403 children with confirmed and probable CZS who died up to 36 months of age were included in the study; 81.9% were younger than 12 months of age. Multiple congenital malformations not classified elsewhere, and septicemia unspecified, with 18 (PM = 4.5%) and 17 (PM = 4.2%) deaths, respectively, were the most attested underlying causes of death. Unspecified septicemia (29 deaths and PM = 11.2%) and newborn respiratory failure (40 deaths and PM = 12.1%) were, respectively, the predominant intermediate and immediate causes of death. Fetuses and newborns affected by the mother's infectious and parasitic diseases, unspecified cerebral palsy, and unspecified severe protein-caloric malnutrition were the underlying causes with the greatest probability of death in children with CZS (PMRc from 10.0 to 17.0) when compared to the group born with non-Zika CNS anomalies. Among the intermediate and immediate causes of death, pneumonitis due to food or vomiting and unspecified seizures (PMRc = 9.5, each) and unspecified bronchopneumonia (PMRc = 5.0) were notable. As contributing causes, fetus and newborn affected by the mother's infectious and parasitic diseases (PMRc = 7.3), unspecified cerebral palsy, and newborn seizures (PMRc = 4.5, each) were more likely to lead to death in children with CZS than in the comparison group. The main limitations of this study were the use of a secondary database without additional clinical information and potential misclassification of cases and controls. Conclusion The sequence of causes and circumstances involved in the deaths of the children with CZS highlights the greater vulnerability of these children to infectious and respiratory conditions compared to children with abnormalities of the CNS not related to Zika.

Published
2023
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16. Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment

Author

Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Hromatka, Bethann S., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Shaffer, John R., Li, Jinxi, Lee, Myoung Keun, Roosenboom, Jasmien, Orlova, Ekaterina, Adhikari, Kaustabh, Gallo, Carla, Poletti, Giovanni, Schuler-Faccini, Lavinia, Bortolini, Maria-Cátira, Canizales-Quinteros, Samuel, Rothhammer, Francisco, Bedoya, Gabriel, González-José, Rolando, Pfeffer, Paige E., Wollenschlaeger, Christopher A., Hecht, Jacqueline T., Wehby, George L., Moreno, Lina M., Ding, Anan, Jin, Li, Yang, Yajun, Carlson, Jenna C., Leslie, Elizabeth J., Feingold, Eleanor, Marazita, Mary L., Cox, Timothy C., Wang, Sijia, Ruiz-Linares, Andrés, and Weinberg, Seth M.

Published
2017
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25. The role of glial cells in Zika virus‐induced neurodegeneration

Author

Quincozes‐Santos, André, primary, Bobermin, Larissa Daniele, additional, Costa, Naithan Ludian Fernandes, additional, Thomaz, Natalie K., additional, Almeida, Rômulo Rodrigo de Souza, additional, Beys‐da‐Silva, Walter O., additional, Santi, Lucélia, additional, Rosa, Rafael L., additional, Capra, Daniela, additional, Coelho‐Aguiar, Juliana M., additional, DosSantos, Marcos Fabio, additional, Heringer, Manoela, additional, Cirne‐Lima, Elizabeth O., additional, Guimarães, Jorge Almeida, additional, Schuler‐Faccini, Lavínia, additional, Gonçalves, Carlos‐Alberto, additional, Moura‐Neto, Vivaldo, additional, and Souza, Diogo Onofre, additional

Published
2023
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28. Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015

Author

Brazilian Medical Genetics Society–Zika Embryopathy Task Force, Schuler-Faccini, Lavinia, Ribeiro, Erlane M., Feitosa, Ian M.L., Horovitz, Dafne D.G., Cavalcanti, Denise P., Pessoa, André, Doriqui, Maria Juliana R., Neri, Joao Ivanildo, de Pina Neto, Joao Monteiro, Wanderley, Hector Y.C., Cernach, Mirlene, El-Husny, Antonette S., Pone, Marcos V.S., Serao, Cassio L.C., and Sanseverino, Maria Teresa V.

Published
2016

29. Profile of calls and activities of the first Teratogen Information Service in Latin America through 32 years

Author

Schuler-Faccini, Lavínia, Sanseverino, Maria Teresa V., e Silva, Sacha Krolow, Barbosa, Camila P., Ordovás, Danton S., Arashiro, Carolina S., Rohweder, Ricardo, Ornaghi, Ana Paula, Sanchez, Filipe M., Radin, Giulia, Gomes, Victoria L.S., Pires, Lucas M., Martins, Antonia S., Fighera, Gabriella Z., Abeche, Alberto M., Vianna, Fernanda S.L., Fraga, Lucas R., and Silva, André A.

Published
2023
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30. Expert consensus on neurodevelopmental outcomes in pregnancy pharmacovigilance studies

Author

Bromley, Rebecca, Graz, Miriam Bickle, Bluett-Duncan, Matthew, Chambers, Christina, Damkier, Per, Dietrich, Kim, Dolk, Helen, Grant, Kimberley, Mattson, Sarah, Meador, Kim, Nordeng, Hedvig, Oberlander, Tim, Ornoy, Asher, Revet, Alexis, Richardson, Jonathan, Rovet, Joanne, Schuler-Faccini, Lavinia, Smearman, Erica, Simms, Victoria, Vorhees, Charles, Wide, Katrina, Wood, Amanda, Yates, Laura, Ystrom, Evinid, Supraja, T.A., and Adams, Jane

Published
2023
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31. Risk of adverse outcomes in offspring with RT-PCR confirmed prenatal Zika virus exposure: an individual participant data meta-analysis of 13 cohorts in the Zika Brazilian Cohorts Consortium

Author

Arraes de Alencar Ximenes, Ricardo, primary, de Barros Miranda-Filho, Demócrito, additional, Brickley, Elizabeth B., additional, Barreto de Araújo, Thalia Velho, additional, Montarroyos, Ulisses Ramos, additional, Abtibol-Bernardino, Marília Rosa, additional, Mussi-Pinhata, Marisa M., additional, Duarte, Geraldo, additional, Coutinho, Conrado Milani, additional, Biason de Moura Negrini, Silvia Fabiana, additional, Alecrim, Maria das Graças Costa, additional, Albuquerque de Almeida Peixoto, Lucíola de Fátima, additional, Lopes Moreira, Maria Elisabeth, additional, Zin, Andrea, additional, Pereira Júnior, José Paulo, additional, Nielsen-Saines, Karin, additional, Turchi Martelli, Celina Maria, additional, Rodrigues, Laura Cunha, additional, Vieira de Souza, Wayner, additional, Ventura, Liana O., additional, Silva de Oliveira, Consuelo, additional, de Matos, Haroldo, additional, Furtado Serra, Emilene Monteiro, additional, Souza Gomes, Luna Thais, additional, Nogueira, Maurício L., additional, Estofolete, Cassia, additional, Vaz-Oliani, Denise Cristina, additional, Passos, Saulo Duarte, additional, Moron, Antonio, additional, Duarte Rodrigues, Maria Manoela, additional, Pereira Sarmento, Stéphanno Gomes, additional, Turchi, Marília Dalva, additional, Pela Rosado, Luiza Emylce, additional, de Sene Amâncio Zara, Ana Laura, additional, Franco Gomes, Maria Bárbara, additional, Schuler-Faccini, Lavínia, additional, Herrero-Silva, Juliana, additional, Amorim, Melania M., additional, Melo, Adriana Oliveira, additional, Ledo Alves da Cunha, Antônio José, additional, Prata-Barbosa, Arnaldo, additional, Amim, Joffre, additional, Rezende-Filho, Jorge, additional, Calcagno, Juan Ignacio, additional, Júnior Alcântara, Luiz Carlos, additional, Lima de Almeida, Breno, additional, Hofer, Cristina Barroso, additional, Machado, Elizabeth S., additional, de Siqueira, Isadora Cristina, additional, Martinez-Espinosa, Flor Ernestina, additional, Brasil, Patrícia, additional, de Carvalho Leal, Mariana, additional, de Albuquerque, Maria de Fátima Pessoa Militão, additional, Malacarne, Jociele, additional, Damasceno, Luana, additional, de Filippis, Ana Maria Bispo, additional, Santos, Cleiton Silva, additional, Duarte, Alan Oliveira, additional, Vasconcelos, Pedro Fernando, additional, Machado, Mariana Borges, additional, Bertozzi, Ana paula Antunes Pascalicchio, additional, Gillo Fajardo, Thamirys Cosmo, additional, Tiraboschi Bárbaro, Adriana Aparecida, additional, Marçal Assef, Ligia Conceição, additional, Pimentel, Clarice, additional, Abreu, Thalita, additional, de Sales Tavares, Jousilene, additional, de Oliveira Melo, Fabiana, additional, de Toledo Lima, Talita, additional, Brasil, Maria das Graças Nunes, additional, Terças-Trettel, Cláudia Pereira, additional, de Araújo França, Giovanny Vinícius, additional, Aguiar Bôtto-Menezes, Camila Helena, additional, Benzecry, Silvana Gomes, additional, Robaina, Jaqueline Rodrigues, additional, and de Oliveira, Mariana Barros Genuíno, additional

Published
2023
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32. Microcephaly in South Brazil: Are cases of Congenital Zika Syndrome increasing in recent years?

Author

Terra, Anna Pires, primary, Rohweder, Ricardo, additional, Herber, Silvani, additional, Friedrich, Luciana, additional, Sanseverino, Maria Teresa Vieira, additional, Favreto, Catia, additional, Maria, Fernanda Santa, additional, Athayde, Emilly de Jesus, additional, Cardoso-Júnior, Laércio Moreira, additional, Marinho, Andrea Cristina Pereira, additional, Marinho, Allanamara Pereira, additional, Zarpelon, Tailine, additional, and Schuler-Faccini, Lavínia, additional

Published
2023
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35. Preparing for the rapid research response to the possible vertical transmission of Oropouche virus: lessons from a decade of congenital Zika research

Author

de Albuquerque, Maria de Fátima P M, de Albuquerque, Maria do Socorro Veloso, Almeida, Bethânia de Araujo, de Araújo, Thalia Velho Barreto, Barreto, Mauricio Lima, Brainer, Alessandra Mertens, Brasil, Patrícia, Brickley, Elizabeth B., Carvalho, Maria Durce Costa Gomes, Castilho, Marcia da Costa, Coelho, Bernadete Perez, Cortes, Fanny, Duarte, Geraldo, Eickmann, Sophie H., Espinosa, Flor Ernestina Martinez, Fontes, Juliana, de Freitas, Maria Maia Vieira, Fulco, Gabriela, Gonçalves, Andréia Veras, Gurgel, Ricardo Queiroz, Hofer, Cristina Barroso, Leigh, Lamin, Lima, Mariana Ramos Pitta, Sá, Ana Carolyne de Carvalho Lucena, Lyra, Tereza, Martelli, Celina Maria Turchi, Medeiros, Valquíria, de Melo, Ana Paula Lopes, Miranda-Filho, Demócrito de Barros, Montarroyos, Ulisses Ramos, Moreira, Maria Elisabeth Lopes, Mussi-Pinhata, Marisa Marcia, Nascimento, Jeddson do Rêgo, Nogueira, Maurício, Paixao, Enny S, de Oliveira, Consuelo Silva, Penn-Kekana, Loveday, Pescarini, Júlia M, Pinto, Maria Helena, Prata-Barbosa, Arnaldo, Raja, Amber I, Ramos, Regina C, Rocha, Maria Ângela W, Rodrigues, Laura Cunha, Clemente, Nuria Sanchez, dos Santos, Jhulia, Scalabrin, Deolinda Maria Felin, Schuler-Faccini, Lavínia, da Silva, Antônio Augusto M, Oliveira, Danielle MS, Sobral da Silva, Paula Fabiana, de Siqueira, Isadora Cristina, de Souza, Emanuelle Queiroz dos Santos Tenório, de Souza, Wayner Vieira, Teixeira, Maria da Gloria, Turchi, Marilia Dalva, de Vasconcelos, Rômulo A.L., Ximenes, Ricardo Arraes de Alencar, Valongueiro, Sandra, and Brickley, Elizabeth B

Published
2024
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39. Neurodevelopment in Children Exposed to Zika in utero: Clinical and Molecular Aspects

Author

Schuler-Faccini, Lavínia, primary, del Campo, Miguel, additional, García-Alix, Alfredo, additional, Ventura, Liana O., additional, Boquett, Juliano André, additional, van der Linden, Vanessa, additional, Pessoa, André, additional, van der Linden Júnior, Hélio, additional, Ventura, Camila V., additional, Leal, Mariana Carvalho, additional, Kowalski, Thayne Woycinck, additional, Rodrigues Gerzson, Lais, additional, Skilhan de Almeida, Carla, additional, Santi, Lucélia, additional, Beys-da-Silva, Walter O., additional, Quincozes-Santos, André, additional, Guimarães, Jorge A., additional, Garcez, Patricia P., additional, Gomes, Julia do Amaral, additional, Vianna, Fernanda Sales Luiz, additional, Anjos da Silva, André, additional, Fraga, Lucas Rosa, additional, Vieira Sanseverino, Maria Teresa, additional, Muotri, Alysson R., additional, Lopes da Rosa, Rafael, additional, Abeche, Alberto Mantovani, additional, Marcolongo-Pereira, Clairton, additional, and Souza, Diogo O., additional

Published
2022
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40. Evaluation of Polymorphisms in Toll-Like Receptor Genes as Biomarkers of the Response to Treatment of Erythema Nodosum Leprosum

Author

Maciel-Fiuza, Miriãn Ferrão, primary, Costa, Perpétua do Socorro Silva, additional, Kowalski, Thayne Woycinck, additional, Schuler-Faccini, Lavínia, additional, Bonamigo, Renan Rangel, additional, Vetoratto, Rodrigo, additional, Eidt, Letícia Maria, additional, de Moraes, Paulo Cezar, additional, Silveira, Maria Irismar da Silva, additional, Camargo, Luis Marcelo Aranha, additional, Callegari-Jacques, Sidia Maria, additional, Castro, Stela Maris de Jezus, additional, and Vianna, Fernanda Sales Luiz, additional

Published
2022
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41. Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide

Author

Costa, Perpétua do Socorro Silva, primary, Maciel-Fiuza, Miriãn Ferrão, additional, Kowalski, Thayne Woycinck, additional, Fraga, Lucas Rosa, additional, Feira, Mariléa Furtado, additional, Camargo, Luís Marcelo Aranha, additional, Caldoncelli, Daniele Iop de Oliveira, additional, Silveira, Maria Irismar da Silva, additional, Schuler-Faccini, Lavínia, additional, and Vianna, Fernanda Sales Luiz, additional

Published
2022
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42. Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy

Author

Alecrim, Maria das Graças Costa, Amorim, Melania Maria Ramos de, Araújo, Thalia Velho Barreto de, Brasil, Patrícia, Brickley, Elizabeth B, Castilho, Marcia da Costa, Coelho, Bernadete Perez, Cunha, Antônio José Ledo Alves da, Duarte, Geraldo, Estofolete, Cássia Fernanda, Gurgel, Ricardo Queiroz, Herrero-Silva, Juliana, Hofer, Cristina Barroso, Lopes, Aline Siqueira Alves, Martelli, Celina Maria Turchi, Melo, Adriana Suely de Oliveira, Miranda-Filho, Demócrito de Barros, Montarroyos, Ulisses Ramos, Moreira, Maria Elisabeth, Mussi-Pinhata, Marisa Marcia, Oliveira, Consuelo Silva de, Passos, Saulo Duarte, Prata-Barbosa, Arnaldo, Santos, Darci Neves Dos, Schuler-Faccini, Lavínia, Silva, Antônio Augusto Moura da, Siqueira, Isadora Cristina de, Sousa, Patrícia da Silva, Turchi, Marília Dalva, Ximenes, Ricardo Arraes de Alencar, Zara, Ana Laura de Sene Amâncio, and Zika Brazilian Cohorts Consortium Zbc-Consortium

Abstract

Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions.

Published
2021

46. Additional file 1 of Molecular mechanisms of Zika virus teratogenesis from animal studies: a systematic review protocol

Author

Wachholz, Gabriela Elis, do Amaral Gomes, Julia, Boquett, Juliano André, Vianna, Fernanda Sales Luiz, Schuler-Faccini, Lavínia, and Fraga, Lucas Rosa

Subjects
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional File 1: Table S1. Draft Search Strategy. Table S2. List of data to be extracted from the studies included in the systematic review.

Published
2021
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47. Functional Polymorphisms in the p53 Pathway Genes on the Genetic Susceptibility to Zika Virus Teratogenesis

Author

Gomes, Julia A., primary, Sgarioni, Eduarda, additional, Vieira, Igor A., additional, Fraga, Lucas R., additional, Ashton-Prolla, Patrícia, additional, Terças-Tretell, Ana Cláudia P., additional, da Silva, Juliana H., additional, Ribeiro, Bethânia F.R., additional, Galera, Marcial F., additional, de Oliveira, Thalita M., additional, Carvalho de Andrade, Maria Denise F., additional, Carvalho, Isabella F., additional, Schuler-Faccini, Lavínia, additional, and Vianna, Fernanda S. L., additional

Published
2021
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50. Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of ENL with thalidomide

Author

Costa, Perpétua Socorro Silva, primary, Ferrão, Miriãn, additional, Kowalski, Thayne Woycinck, additional, Fraga, Lucas Rosa, additional, Feira, Mariléa Furtado, additional, Camargo, Luís Marcelo Aranha, additional, Caldoncelli, Daniele Iop Oliveira, additional, Silveira, Maria Irismar Silva, additional, Schuler-Faccini, Lavínia, additional, and Vianna, Fernanda, additional

Published
2021
Full Text
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