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2. Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael

Published
2024
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3. Trends in use of neoadjuvant systemic therapy in patients with clinically node-positive breast cancer in Europe: prospective TAXIS study (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Tausch, Christoph, Däster, Kavitha, Hayoz, Stefanie, Matrai, Zoltan, Fitzal, Florian, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Maggi, Nadia, Saccilotto, Ramon, Heidinger, Martin, Mueller, Andreas, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Ruhstaller, Thomas, Muenst, Simone, Kuemmel, Sherko, Vrieling, Conny, Satler, Rok, Becciolini, Charles, Bucher, Susanne, Kurzeder, Christian, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Montagna, Giacomo, Reitsamer, Roland, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Naydina, Tatiana, Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, and Weber, Walter Paul

Published
2023
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6. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., Heidinger, Martin, Hayoz, Stefanie, Matrai, Zoltan, Tausch, Christoph, Henke, Guido, Zwahlen, Daniel R., Gruber, Günther, Zimmermann, Frank, Montagna, Giacomo, Andreozzi, Mariacarla, Goldschmidt, Maite, Schulz, Alexandra, Mueller, Andreas, Ackerknecht, Markus, Tampaki, Ekaterini Christina, Bjelic-Radisic, Vesna, Kurzeder, Christian, Sávolt, Ákos, Smanykó, Viktor, Hagen, Daniela, Müller, Dieter J., Gnant, Michael, Loibl, Sibylle, Fitzal, Florian, Markellou, Pagona, Bekes, Inga, Egle, Daniel, Heil, Jörg, and Knauer, Michael

Published
2024
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12. Knowledge gaps in oncoplastic breast surgery

Author

González, Eduardo, Elzayat, Mona, Koller, Rupert, Gnant, Michael, Brenelli, Fabricio, Paulinelli, Regis Resende, Zobel, Vappu, Joukainen, Sarianna, Karhunen-Enckell, Ulla, Kauhanen, Susanna, Piat, Jean-Marc, Bjelic-Radisic, Vesna, Faridi, Andree, Heitmann, Christoph, Hoffmann, Juergen, Kneser, Ulrich, Kümmel, Sherko, Kühn, Thorsten, Kontos, Michalis, Tampaki, Ekaterini Christina, Barry, Mitchel, Allweis, Tanir M, Carmon, Moshe, Hadar, Tal, Catanuto, Giuseppe, Garcia-Etienne, Carlos A, Gentilini, Oreste D, Knox, Susan, Klein, Barbara, Koppert, Linetta, Gouveia, Pedro F, Svensjö, Tor, Bucher, Heiner C, Ess, Silvia, Ganz-Blättler, Ursula, Günthert, Andreas, Hauser, Nik, Hynes, Nancy, Knauer, Michael, Pfeiffer, Marlen, Rochlitz, Christoph, Tausch, Christoph, Harder, Yves, Zimmermann, Frank, Schwab, Fabienne D, D'Amico, Veronica, Soysal, Savas D, Castrezana Lopez, Liliana, Fulco, Ilario, Hemkens, Lars G, Lohsiriwat, Visnu, Gulluoglu, Bahadir M, Karadeniz, Guldeniz, Karanlik, Hasan, Sezer, Atakan, Gulcelik, Mehmet Ali, Emiroglu, Mustafa, Kovacs, Tibor, Rattay, Tim, Romics, Laszlo, Vidya, Raghavan, Wyld, Lynda, El-Tamer, Mahmoud, Sacchini, Virgilio, Weber, Walter P, Morrow, Monica, Boniface, Jana de, Pusic, Andrea, Montagna, Giacomo, Kappos, Elisabeth A, Ritter, Mathilde, Haug, Martin, Kurzeder, Christian, Saccilotto, Ramon, Schulz, Alexandra, Benson, John, Fitzal, Florian, Matrai, Zoltan, Shaw, Jane, Peeters, Marie-Jeanne Vrancken, Potter, Shelley, and Heil, Joerg

Published
2020
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13. The LYMPH Trial - Comparing Microsurgical with Conservative Treatment of Chronic Breast Cancer Associated Lymphedema: Study Protocol of a Pragmatic Randomized International Multicentre Superiority Trial

Author

Kappos, Elisabeth A, primary, Haas, Yvonne, additional, Schulz, Alexandra, additional, Peters, Florian, additional, Savanthrapadian, Shakuntala, additional, Stoffel, Julia, additional, Katapodi, Maria, additional, Mucklow, Rosine, additional, Kaiser, Benedict, additional, Haumer, Alexander, additional, Etter, Stephanie, additional, Cattaneo, Marco, additional, Staub, Daniel, additional, Ribi, Karin, additional, Shaw, Jane, additional, Handschin, Tristan M, additional, Eisenhardt, Steffen, additional, Visconti, Giuseppe, additional, Franceschini, Gianluca, additional, Scardina, Lorenzo, additional, Longo, Benedetto, additional, Vetter, Marcus, additional, Zaman, Khalil, additional, Plock, Jan A, additional, Scaglioni, Mario, additional, Gonzalez, Eduardo G, additional, Quildrian, Sergio D, additional, Felmerer, Gunther, additional, Mehrara, Babak J, additional, Masia, Jaume, additional, Pons, Gemma, additional, Kalbermatten, Daniel F, additional, Sacks, Justin M, additional, Halle, Martin, additional, Muntean, Maximillian V, additional, Taylor, Erin M, additional, Mani, Maria, additional, Jung, Florian J, additional, di Summa, Pietro G, additional, Demiri, Efterpi, additional, Dionyssiou, Dimitris, additional, Groth, Anne K, additional, Heine, Norbert, additional, Vorstenborsch, Joshua, additional, Isaac, Kathryn V, additional, Qiu, Shan S, additional, Engels, Patricia E, additional, Serre, Axelle, additional, Eberhardt, Anna-Lena, additional, Ebner, Sonja, additional, Schwenkglenks, Matthias, additional, Stoel, Yvette, additional, Leo, Cornelia, additional, Horch, Raymund E, additional, Blondeel, Phillip, additional, Behr, Bjoern, additional, Kneser, Ulrich, additional, Prantl, Lukas, additional, Boll, Daniel T, additional, Granziera, Cristina, additional, Hemkens, Lars G, additional, Lindenblatt, Nicole, additional, Haug, Martin, additional, Schaefer, Dirk J, additional, Hirche, Christoph, additional, Pusic, Andrea L, additional, Seidenstuecker, Katrin, additional, Harder, Yves, additional, and Weber, Walter P, additional

Published
2024
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14. Accurate parameters of the oldest known rocky-exoplanet hosting system: Kepler-10 revisited

Author

Fogtmann-Schulz, Alexandra, Hinrup, Brian, Van Eylen, Vincent, Christensen-Dalsgaard, Jørgen, Kjeldsen, Hans, Aguirre, Víctor Silva, and Tingley, Brandon

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Since the discovery of Kepler-10, the system has received considerable interest because it contains a small, rocky planet which orbits the star in less than a day. The system's parameters, announced by the Kepler team and subsequently used in further research, were based on only 5 months of data. We have reanalyzed this system using the full span of 29 months of Kepler photometric data, and obtained improved information about its star and the planets. A detailed asteroseismic analysis of the extended time series provides a significant improvement on the stellar parameters: Not only can we state that Kepler-10 is the oldest known rocky-planet-harboring system at 10.41 +/- 1.36 Gyr, but these parameters combined with improved planetary parameters from new transit fits gives us the radius of Kepler-10b to within just 125 km. A new analysis of the full planetary phase curve leads to new estimates on the planetary temperature and albedo, which remain degenerate in the Kepler band. Our modeling suggests that the flux level during the occultation is slightly lower than at the transit wings, which would imply that the nightside of this planet has a non-negligible temperature., Comment: 14 pages (in the used format), 4 figures. Accepted for publication in The Astrophysical Journal at December 3rd 2013

Published
2013
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15. ASO Visual Abstract: Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Heidinger, Martin, additional, Hayoz, Stefanie, additional, Matrai, Zoltan, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Andreozzi, Mariacarla, additional, Goldschmidt, Maite, additional, Schulz, Alexandra, additional, Mueller, Andreas, additional, Ackerknecht, Markus, additional, Tampaki, Ekaterini Christina, additional, Bjelic-Radisic, Vesna, additional, Kurzeder, Christian, additional, Sávolt, Ákos, additional, Smanykó, Viktor, additional, Hagen, Daniela, additional, Müller, Dieter J., additional, Gnant, Michael, additional, Loibl, Sibylle, additional, Fitzal, Florian, additional, Markellou, Pagona, additional, Bekes, Inga, additional, Egle, Daniel, additional, Heil, Jörg, additional, and Knauer, Michael, additional

Published
2023
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16. Impact of Imaging-Guided Localization on Performance of Tailored Axillary Surgery in Patients with Clinically Node-Positive Breast Cancer: Prospective Cohort Study Within TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Heidinger, Martin, additional, Hayoz, Stefanie, additional, Matrai, Zoltan, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Montagna, Giacomo, additional, Andreozzi, Mariacarla, additional, Goldschmidt, Maite, additional, Schulz, Alexandra, additional, Mueller, Andreas, additional, Ackerknecht, Markus, additional, Tampaki, Ekaterini Christina, additional, Bjelic-Radisic, Vesna, additional, Kurzeder, Christian, additional, Sávolt, Ákos, additional, Smanykó, Viktor, additional, Hagen, Daniela, additional, Müller, Dieter J., additional, Gnant, Michael, additional, Loibl, Sibylle, additional, Fitzal, Florian, additional, Markellou, Pagona, additional, Bekes, Inga, additional, Egle, Daniel, additional, Heil, Jörg, additional, and Knauer, Michael, additional

Published
2023
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25. CO2BioPerm—Influence of Bio-geochemical CO2-Transformation Processes on the Long-Term Permeability

Author

Hoth, Nils, Gniese, Claudia, Rakoczy, Jana, Weber, Anne, Kümmel, Steffen, Reichel, Susan, Freese, Carsten, Hache, Michaela, Kassahun, Andrea, Schulz, Alexandra, Fischer, Heike, Mühling, Martin, Starke, Robert, Kahnt, Rene, Vogt, Carsten, Richnow, Hans-Hermann, Krüger, Martin, Schippers, Axel, Schlömann, Michael, Münch, Ute, Series editor, Stroink, Ludwig, Series editor, Mosbrugger, Volker, Series editor, Wefer, Gerold, Series editor, and Liebscher, Axel, editor

Published
2015
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27. Abstract PD15-11: PD15-11 Axillary dissection to determine nodal burden to inform systemic therapy recommendations in patients with clinically node-positive breast cancer: Pre-planned substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101)

Author

Weber, Walter P., primary, Matrai, Zoltan, additional, Hayoz, Stefanie, additional, Tausch, Christoph, additional, Henke, Guido, additional, Zwahlen, Daniel R., additional, Gruber, Günther, additional, Zimmermann, Frank, additional, Ruhstaller, Thomas, additional, Muenst, Simone, additional, Ackerknecht, Markus, additional, Küemmel, Sherko, additional, Bjelic-Radisic, Vesna, additional, Smanykó, Viktor, additional, Vrieling, Conny, additional, Satler, Rok, additional, Meyer, Inna, additional, Becciolini, Charles, additional, Bucher, Susanne, additional, Simonson, Colin, additional, Fehr, Peter M., additional, Gabriel, Natalie, additional, Maráz, Robert, additional, Sarlos, Dimitri, additional, Dedes, Konstantin J., additional, Leo, Cornelia, additional, Berclaz, Gilles, additional, Fansa, Hisham, additional, Hager, Christopher, additional, Reisenberger, Klaus, additional, Sávolt, Ákos, additional, Singer, Christian F., additional, Reitsamer, Roland, additional, Winkler, Jelena, additional, Lam, Giang Thanh Lam, additional, Fehr, Mathias K., additional, Naydina, Tatiana, additional, Kohlik, Magdalena, additional, Clerc, Karine, additional, Ostapenko, Valerijus, additional, Fitzal, Florian, additional, Heidinger, Martin, additional, Maggi, Nadia, additional, Schulz, Alexandra, additional, Markellou, Pagona, additional, Lelièvre, Loïc, additional, Egle, Daniel, additional, Heil, Jörg, additional, Knauer, Michael, additional, and Kurzeder, Christian, additional

Published
2023
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28. Danske OA-tidsskrifter og Directory of Open Access Journals (DOAJ)

Author

Gemzøe, Anna Stegger, Fogtmann-Schulz, Alexandra, Johnsen, Solveig Sandal, Thestrup, Jesper Boserup, Hansen, Claus Rosenkrantz, Riise, Rasmus Rindom, Iversen, Rie Karen Marie, Gemzøe, Anna Stegger, Fogtmann-Schulz, Alexandra, Johnsen, Solveig Sandal, Thestrup, Jesper Boserup, Hansen, Claus Rosenkrantz, Riise, Rasmus Rindom, and Iversen, Rie Karen Marie

Abstract

Rapporten beskriver et projekt, der skulle få flere danske tidsskrifter optaget i DOAJ. Projektet blev initieret i efteråret 2020 og påbegyndt januar 2021. Baggrunden har været at styrke kommunikation, samarbejde og videndeling på tværs af universitetsbiblioteker inden for Det Kgl. Bibliotek, men også at samarbejde nationalt med andre universitetsbiblioteker, der arbejder med OJS servere (Aalborg Universitetsbibliotek og Copenhagen Business School). Initiativet er igangsat for at øge kvalitet og synlighed af Det Kgl. Biblioteks Open Science services samt styrke OA-tidsskrifterne i forhold til synlighed og trafik.

Published
2023

29. Danish OA journals and Directory of Open Access Journals (DOAJ) ENGLISH version:Delvist engelsk tekst

Author

Gemzøe, Anna Stegger, Fogtmann-Schulz, Alexandra, Johnsen, Solveig Sandal, Thestrup, Jesper Boserup, Hansen, Claus Rosenkrantz, Riise, Rasmus Rindom, Iversen, Rie Karen Marie, Gemzøe, Anna Stegger, Fogtmann-Schulz, Alexandra, Johnsen, Solveig Sandal, Thestrup, Jesper Boserup, Hansen, Claus Rosenkrantz, Riise, Rasmus Rindom, and Iversen, Rie Karen Marie

Abstract

Dele af rapporten er på engelsk. Rapporten beskriver et projekt, der skulle få flere danske tidsskrifter optaget i DOAJ. Projektet blev initieret i efteråret 2020 og påbegyndt januar 2021. Baggrunden har været at styrke kommunikation, samarbejde og videndeling på tværs af universitetsbiblioteker inden for Det Kgl. Bibliotek, men også at samarbejde nationalt med andre universitetsbiblioteker, der arbejder med OJS servere (Aalborg Universitetsbibliotek og Copenhagen Business School). Initiativet er igangsat for at øge kvalitet og synlighed af Det Kgl. Biblioteks Open Science services samt styrke OA-tidsskrifterne i forhold til synlighed og trafik. Dette er en forkortet udgave af den danske version. Yderligere oplysninger om projektet kan fås ved henvendelse til den primære kontaktperson.

Published
2023

37. Danish OA journals and Directory of Open Access Journals (DOAJ) ENGLISH version

Author

Stegger Gemzøe, Anna, Fogtmann Schulz, Alexandra, Sandal Johnsen, Solveig, Boserup Thestrup, Jesper, Rosenkrantz Hansen, Claus, Rindom Riise, Rasmus, and Iversen, Karen Marie

Abstract

Dele af rapporten er på engelsk. Rapporten beskriver et projekt, der skulle få flere danske tidsskrifter optaget i DOAJ. Projektet blev initieret i efteråret 2020 og påbegyndt januar 2021. Baggrunden har været at styrke kommunikation, samarbejde og videndeling på tværs af universitetsbiblioteker inden for Det Kgl. Bibliotek, men også at samarbejde nationalt med andre universitetsbiblioteker, der arbejder med OJS servere (Aalborg Universitetsbibliotek og Copenhagen Business School). Initiativet er igangsat for at øge kvalitet og synlighed af Det Kgl. Biblioteks Open Science services samt styrke OA-tidsskrifterne i forhold til synlighed og trafik.

Published
2023

38. D6.1 Mapping of existing professional networks

Author

Buss, Mareike, Athanasaki, Evangelia, Bernier, Mathilde, Drachen, Thea Marie, Fogtmann-Schulz, Alexandra, Hadrossek, Christine, Horton, Laurence, Janik, Joanna, Moldrup-Dalum, Per, Pasquale, Valentina, Schöller, Emily Thorsson, Sharma, Curtis, Torres Ramos, Gabriela, Ulfsparre, Sanna Isabel, and Vlachos, Evgenios

Subjects
Open Science, Research Infrastructure, Coomunity, Data Science, HPC, RDM, Networks, AI curation, Research Integrity, FAIR
Abstract

Submitted draft not yet approved by the EC This is Skills4EOSC Deliverable D6.1 Mapping of existing professional networks. This deliverable provides an overview of the current landscape of Open Science related professional networks in Europe., {"references":["Armeni, K. et al. (2021). Towards wide-scale adoption of open science practices: The role of open science communities. Science and Public Policy 48(5), 605–611. https://doi.org/10.1093/scipol/scab039","Bodlos, A. et al. (2020). Summary report of the EOSC-Pillar \"National Initiatives Survey\". Version 1.1, Zenodo. https://doi.org/10.5281/zenodo.3937317","Cedefop (2014). Terminology of European education and training policy: A selection of 130 terms. Publications Office. https://data.europa.eu/doi/10.2801/15877","Forlenza, D. et al. (2021). EOSC: Landscaping Analysis. Zenodo. https://doi.org/10.5281/zenodo.4683278","Hager, P. (2021). Concepts and definitions of lifelong learning. In London, M. (ed.). The Oxford Handbook of Lifelong Learning. 2. ed. Oxford: Oxford Academic. https://doi.org/10.1093/oxfordhb/9780197506707.013.2","Hammargren, P.-O. et al. (2020). D2.1 Open Science Policies and Resource Provisioning in the Nordic and Baltic Countries (first report). Zenodo. https://doi.org/10.5281/zenodo.4083762","Hammargren, P.-O. et al. (2021). D2.5: Open Science Policies and Resource Provisioning in the Nordic and Baltic Countries (second report). Zenodo. https://doi.org/10.5281/zenodo.5537068","Hansson, E.-L. et al. (2022). D2.8: Open Science Policies and Resource Provisioning in the Nordic and Baltic Countries (final report). Zenodo. https://doi.org/10.5281/zenodo.6503709","Kolb, A. Y. & Kolb, D. A. (2017). Learning styles and learning spaces: Enhancing experiential learning in higher education. Academy of Management Learning & Education, 4(2), 193–212. http://dx.doi.org/10.5465/AMLE.2005.17268566","Kosanović, B. & Ševkušić, M. (2019). NI4OS-Europe Stakeholder Map, Inventory, Policy Matrix. Zenodo. https://doi.org/10.5281/zenodo.3736129","Kosanović, B. & Ševkušić, M. (2022). NI4OS-Europe Stakeholder Map, Inventory, Policy Matrix Update. Zenodo. https://doi.org/10.5281/zenodo.6118786","LDK SA (2020). EOSC within National Strategies for Digital Skills: Landscape Report. Zenodo. https://doi.org/10.5281/zenodo.4461379","Manola, N. et al. (editors); European Commission, Directorate-General for Research and Innovation (2021). Digital Skills for FAIR and Open Science: Report from the EOSC Executive Board Skills and Training Working Group. Publications Office. https://data.europa.eu/doi/10.2777/59065","Petticrew, M. & Roberts, H. (2005). Systematic Reviews in the Social Sciences: A Practical Guide. London: Blackwell.","Pontika, N. et al. (2015). Fostering open science to research using a taxonomy and an elearning portal. In: iKnow: 15th International Conference on Knowledge Technologies and Data Driven Business, 21-22 Oct 2015, Graz, Austria. https://doi.org/10.1145/2809563.2809571","Volles, Nina (2016). Lifelong Learning in the EU: Changing Conceptualisations, Actors, and Policies. Studies in Higher Education 41(2), 343-363. https://doi.org/10.1080/03075079.2014.927852"]}

Published
2023
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47. Association of Axillary Dissection With Systemic Therapy in Patients With Clinically Node-Positive Breast Cancer

Author

Weber, Walter P., Matrai, Zoltan, Hayoz, Stefanie, Tausch, Christoph, Henke, Guido, Zimmermann, Frank, Montagna, Giacomo, Fitzal, Florian, Gnant, Michael, Ruhstaller, Thomas, Muenst, Simone, Mueller, Andreas, Lelièvre, Loïc, Heil, Jörg, Knauer, Michael, Egle, Daniel, Sávolt, Ákos, Heidinger, Martin, Kurzeder, Christian, Zwahlen, Daniel R., Gruber, Günther, Ackerknecht, Markus, Kuemmel, Sherko, Bjelic-Radisic, Vesna, Smanykó, Viktor, Vrieling, Conny, Satler, Rok, Hagen, Daniela, Becciolini, Charles, Bucher, Susanne, Simonson, Colin, Fehr, Peter M., Gabriel, Natalie, Maráz, Robert, Sarlos, Dimitri, Dedes, Konstantin J., Leo, Cornelia, Berclaz, Gilles, Fansa, Hisham, Hager, Christopher, Reisenberger, Klaus, Singer, Christian F., Loibl, Sibylle, Winkler, Jelena, Lam, Giang Thanh, Fehr, Mathias K., Kohlik, Magdalena, Clerc, Karine, Ostapenko, Valerijus, Maggi, Nadia, Schulz, Alexandra, Andreozzi, Mariacarla, Goldschmidt, Maite, Saccilotto, Ramon, and Markellou, Pagona

Abstract

IMPORTANCE: The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)–positive breast cancer (BC) is currently unknown. OBJECTIVE: To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT). DESIGN, SETTING, AND PARTICIPANTS: This was a prospective, observational, cohort study conducted from August 2018 to June 2022. This was a preplanned study within the phase 3 randomized clinical OPBC-03/TAXIS trial. Included were patients with confirmed cN-positive BC from 44 private, public, and academic breast centers in 6 European countries. After NACT, residual nodal disease was mandatory, and a minimum follow-up of 2 months was required. EXPOSURES: All patients underwent tailored axillary surgery (TAS) followed by ALND or axillary radiotherapy (ART) according to TAXIS randomization. TAS removed suspicious palpable and sentinel nodes, whereas imaging-guidance was optional. Systemic therapy recommendations were at the discretion of the local investigators. RESULTS: A total of 500 patients (median [IQR] age, 57 [48-69] years; 487 female [97.4%]) were included in the study. In the upfront surgery setting, 296 of 335 patients (88.4%) had hormone receptor (HR)–positive and Erb-B2 receptor tyrosine kinase 2 (ERBB2; formerly HER2 or HER2/neu)–negative disease: 145 (49.0%) underwent ART, and 151 (51.0%) underwent ALND. The median (IQR) number of removed positive lymph nodes without ALND was 3 (1-4) nodes compared with 4 (2-9) nodes with ALND. There was no association of ALND with the proportion of patients undergoing adjuvant chemotherapy (81 of 145 [55.9%] vs 91 of 151 [60.3%]; adjusted odds ratio [aOR], 0.72; 95% CI, 0.19-2.67) and type of systemic therapy. Of 151 patients with NACT, 74 (51.0%) underwent ART, and 77 (49.0%) underwent ALND. The ratio of removed to positive nodes was a median (IQR) of 4 (3-7) nodes to 2 (1-3) nodes and 15 (12-19) nodes to 2 (1-5) nodes in the ART and ALND groups, respectively. There was no observed association of ALND with the proportion of patients undergoing postneoadjuvant systemic therapy (57 of 74 [77.0%] vs 55 of 77 [71.4%]; aOR, 0.86; 95% CI, 0.43-1.70), type of postneoadjuvant chemotherapy (eg, capecitabine: 10 of 74 [13.5%] vs 10 of 77 [13.0%]; trastuzumab emtansine–DM1: 9 of 74 [12.2%] vs 11 of 77 [14.3%]), or endocrine therapy (eg, aromatase inhibitors: 41 of 74 [55.4%] vs 36 of 77 [46.8%]; tamoxifen: 8 of 74 [10.8%] vs 6 of 77 [7.8%]). CONCLUSION: Results of this cohort study suggest that patients without ALND were significantly understaged. However, ALND did not inform systemic therapy recommendations.

Published
2023
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