354 results on '"Schulze, U"'
Search Results
2. Entlassmanagement in der Kinder- und Jugendpsychiatrie: Erwartungen und Realitäten aus Sicht der Eltern
- Author
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Boege, I., Williams, B., Schulze, U., and Fegert, J. M.
- Published
- 2021
- Full Text
- View/download PDF
3. Psychosocial risk factors for suicidality in children and adolescents
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Carballo, J. J., Llorente, C., Kehrmann, L., Flamarique, I., Zuddas, A., Purper-Ouakil, D., Hoekstra, P. J., Coghill, D., Schulze, U. M. E., Dittmann, R. W., Buitelaar, J. K., Castro-Fornieles, J., Lievesley, K., Santosh, Paramala, and Arango, C.
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- 2020
- Full Text
- View/download PDF
4. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services
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Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., Zanetti E., Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., and Zanetti E.
- Abstract
Purpose: The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods: Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results: Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion: Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.
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- 2022
5. Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.
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Bai, Y., Bentley, L., Ma, C., Naveenan, N., Cleak, J., Wu, Y., Simon, M.M., Westerberg, H., Cañas, R.C., Horner, N., Pandey, R., Paphiti, K., Schulze, U., Mianné, J., Hough, T., Teboul, L., Baaij, J.H.F. de, Cox, R.D., Bai, Y., Bentley, L., Ma, C., Naveenan, N., Cleak, J., Wu, Y., Simon, M.M., Westerberg, H., Cañas, R.C., Horner, N., Pandey, R., Paphiti, K., Schulze, U., Mianné, J., Hough, T., Teboul, L., Baaij, J.H.F. de, and Cox, R.D.
- Abstract
01 november 2023, Contains fulltext : 296932.pdf (Publisher’s version ) (Open Access), ARL15, a small GTPase protein, was linked to metabolic traits in association studies. We aimed to test the Arl15 gene as a functional candidate for metabolic traits in the mouse. CRISPR/Cas9 germline knockout (KO) of Arl15 showed that homozygotes were postnatal lethal and exhibited a complete cleft palate (CP). Also, decreased cell migration was observed from Arl15 KO mouse embryonic fibroblasts (MEFs). Metabolic phenotyping of heterozygotes showed that females had reduced fat mass on a chow diet from 14 weeks of age. Mild body composition phenotypes were also observed in heterozygous mice on a high-fat diet (HFD)/low-fat diet (LFD). Females on a HFD showed reduced body weight, gonadal fat depot weight and brown adipose tissue (BAT) weight. In contrast, in the LFD group, females showed increased bone mineral density (BMD), while males showed a trend toward reduced BMD. Clinical biochemistry analysis of plasma on HFD showed transient lower adiponectin at 20 weeks of age in females. Urinary and plasma Mg(2+) concentrations were not significantly different. Our phenotyping data showed that Arl15 is essential for craniofacial development. Adult metabolic phenotyping revealed potential roles in brown adipose tissue and bone development.
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- 2023
6. Healthcare costs for young people transitioning the boundary between child/adolescent and adult mental health services in seven European countries:results from the MILESTONE study
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Canaway, A, Appleton, R, van Bodegom, L, Dieleman, G, Franic, T, Gerritsen, S, de Girolamo, G, Maras, A, Mcnicholas, F, Overbeek, M, Paul, M, Purper-Ouakil, D, Santosh, P, Schulze, U, Singh, SP, Street, C, Tah, P, Tremmery, B, Tuomainen, H, Verhulst, FC, Wolke, D, Madan, J, Canaway, A, Appleton, R, van Bodegom, L, Dieleman, G, Franic, T, Gerritsen, S, de Girolamo, G, Maras, A, Mcnicholas, F, Overbeek, M, Paul, M, Purper-Ouakil, D, Santosh, P, Schulze, U, Singh, SP, Street, C, Tah, P, Tremmery, B, Tuomainen, H, Verhulst, FC, Wolke, D, and Madan, J
- Abstract
Background The boundary between services for children and adolescents and adults has been identified as problematic for young people with mental health problems. Aims To examine the use and cost of healthcare for young people engaged in mental healthcare before and after the child/adolescent and adult service boundary. Method Data from 772 young people in seven European countries participating in the MILESTONE trial were analysed. We analysed and costed healthcare resources used in the 6-month period before and after the service boundary. Results The proportion of young people engaging with healthcare services fell substantially after crossing the service boundary (associated costs €7761 pre-boundary v. €3376 post-boundary). Pre-boundary, the main cost driver was in-patient care (approximately 50%), whereas post-boundary costs were more evenly spread between services; cost reductions were correlated with pre-boundary in-patient care. Severity was associated with substantially higher costs pre- and post-boundary, and those who were engaged specifically with mental health services after the service boundary accrued the greatest healthcare costs post-service boundary. Conclusions Costs of healthcare are large in this population, but fall considerably after transition, particularly for those who were most severely ill. In part, this is likely to reflect improvement in the mental health of young people. However, qualitative evidence from the MILESTONE study suggests that lack of capacity in adult services and young people's disengagement with formal mental health services post-transition are contributing factors. Long-term data are needed to assess the adverse long-term effects on costs and health of this unmet need and disengagement.
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- 2023
7. Effect of managed transition on mental health outcomes for young people at the child-adult mental health service boundary:A randomised clinical trial
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Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, and Hendrickx, Gaëlle
- Abstract
Background Poor transition planning contributes to discontinuity of care at the child-adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC). Methods A two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016.
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- 2023
8. The importance of clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their mental health services in Europe
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van Bodegom, L, Gerritsen, S, Dieleman, G, Overbeek, M, de Girolamo, G, Scocco, P, Hillegers, M, Wolke, D, Rizopoulos, D, Appleton, R, Conti, P, Franić, T, Margari, F, Madan, J, Mcnicholas, F, Nacinovich, R, Pastore, A, Paul, M, Purper-Ouakil, D, Saam, M, Santosh, P, Sartor, A, Schulze, U, Signorini, G, Singh, S, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuomainen, H, Maras, A, van Bodegom, Larissa S, Gerritsen, Suzanne E, Dieleman, Gwendolyn C, Overbeek, Mathilde M, de Girolamo, Giovanni, Scocco, Paolo, Hillegers, Manon H J, Wolke, Dieter, Rizopoulos, Dimitris, Appleton, Rebecca, Conti, Patrizia, Franić, Tomislav, Margari, Francesco, Madan, Jason, McNicholas, Fiona, Nacinovich, Renata, Pastore, Adriana, Paul, Moli, Purper-Ouakil, Diane, Saam, Melanie C, Santosh, Paramala J, Sartor, Anne, Schulze, Ulrike M E, Signorini, Giulia, Singh, Swaran P, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuomainen, Helena, Maras, Athanasios, van Bodegom, L, Gerritsen, S, Dieleman, G, Overbeek, M, de Girolamo, G, Scocco, P, Hillegers, M, Wolke, D, Rizopoulos, D, Appleton, R, Conti, P, Franić, T, Margari, F, Madan, J, Mcnicholas, F, Nacinovich, R, Pastore, A, Paul, M, Purper-Ouakil, D, Saam, M, Santosh, P, Sartor, A, Schulze, U, Signorini, G, Singh, S, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuomainen, H, Maras, A, van Bodegom, Larissa S, Gerritsen, Suzanne E, Dieleman, Gwendolyn C, Overbeek, Mathilde M, de Girolamo, Giovanni, Scocco, Paolo, Hillegers, Manon H J, Wolke, Dieter, Rizopoulos, Dimitris, Appleton, Rebecca, Conti, Patrizia, Franić, Tomislav, Margari, Francesco, Madan, Jason, McNicholas, Fiona, Nacinovich, Renata, Pastore, Adriana, Paul, Moli, Purper-Ouakil, Diane, Saam, Melanie C, Santosh, Paramala J, Sartor, Anne, Schulze, Ulrike M E, Signorini, Giulia, Singh, Swaran P, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuomainen, Helena, and Maras, Athanasios
- Abstract
Background: To study clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their Child and Adolescent Mental Health Service (CAMHS) and its association with mental health indicators, transition recommendations and mental health service (MHS) use. Methods: 763 CAMHS users from eight European countries were assessed using multi-informant and standardised assessment tools at baseline and nine months follow-up. Separate ANCOVA's and pairwise comparisons were conducted to assess whether clinicians' and parents' awareness of young people's suicidal behaviour were associated with mental health indicators, clinician's recommendations to continue treatment and MHS use at nine months follow-up. Results: 53.5 % of clinicians and 56.9 % of parents were unaware of young people's self-reported suicidal behaviour at baseline. Compared to those whose clinicians/parents were aware, unawareness was associated with a 72–80 % lower proportion of being recommended to continue treatment. Self-reported mental health problems at baseline were comparable for young people whose clinicians and parents were aware and unaware of suicidal behaviour. Clinicians' and parents' unawareness were not associated with MHS use at follow-up. Limitations: Aspects of suicidal behaviour, such as suicide ideation, -plans and -attempts, could not be distinguished. Few young people transitioned to Adult Mental Health Services (AMHS), therefore power to study factors associated with AMHS use was limited. Conclusion: Clinicians and parents are often unaware of suicidal behaviour, which decreases the likelihood of a recommendation to continue treatment, but does not seem to affect young people's MHS use or their mental health problems.
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- 2023
9. Controlled homo- and copolymerization of propene and 1-undecene catalyzed by post-metallocenes
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Zakrzewska, S., Komber, H., Häussler, L., Miller, S.A., Nguyen, H.T.H., Voit, B., and Schulze, U.
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- 2015
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10. Synthesis of nanocomposites by in situ metallocene-catalyzed polymerization of propene
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Zakrzewska, S., dos Ouros, A.C., Schramm, N., Jehnichen, D., Häussler, L., Pospiech, D., Voit, B., Schulze, U., and Pastore, H.O.
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- 2015
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11. Correction to: Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology
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Tuomainen, H., Schulze, U., Warwick, J., Paul, M., Dieleman, G. C., Franić, T., de Girolamo, G., Madan, J., Maras, A., McNicholas, F., Purper-Ouakil, D., Santosh, P., Signorini, G., Street, C., Tremmery, S., Verhulst, F. C., Wolke, D., Singh, S. P., and for the MILESTONE consortium
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- 2018
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12. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology
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Tuomainen, H., Schulze, U., Warwick, J., Paul, M., Dieleman, G.C., Franić, T., Madan, J., Maras, A., McNicholas, F., Purper-Ouakil, D., Santosh, P., Signorini, G., Street, C., Tremmery, S., Verhulst, F.C., Wolke, D., Singh, S. P., and for the MILESTONE consortium
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- 2018
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13. Entlassmanagement in der Kinder- und Jugendpsychiatrie
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Boege, I., Williams, B., Schulze, U., and Fegert, J. M.
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Parents ,Motivation ,Children and adolescents ,Koordination ,Interface management ,Adolescent ,Kinder- und Jugendliche ,Originalien ,Provision of care ,Patient Discharge ,Hospitalization ,Schnittstellenmanagement ,Adolescent Psychiatry ,Coordination ,Humans ,Versorgung ,Mental health ,Psychische Erkrankung ,Child - Abstract
Interface management after inpatient care for mentally ill children and adolescents has been proven to be a breaking point in good transition of care between child and adolescent psychiatry, social welfare services, schools, job centre and the judicial system. Criteria for successful discharge management do not exist in child and adolescent psychiatry. Aim of the study ASpeKT was to survey parents on their perception of interface management and to derive recommendations for discharge management.Data regarding interface management were retrieved from parents (T3, n = 124, T4, n = 81) 6 months (T3) and 12 months (T4) after discharge.The parents stated that accessible help after discharge from inpatient treatment is essential for stability and requires a good coordination. Parents named that they perceived helpful for successful interface management: a case manager, early round table meetings, support in returning to school, seamless access to outpatient follow-up appointments as well as information on further treatment options and contact data.From the perspective of affected families a proactive early individual and reliable care coordination by a constant contact person is essential for a good discharge management.HINTERGRUND UND FRAGESTELLUNG: Schnittstellen zwischen stationärer Behandlung psychisch erkrankter Kinder und Jugendlicher in der Kinder- und Jugendpsychiatrie, Jugendhilfe, Schulen, Arbeitsamt und Justiz sind nachweislich Sollbruchstellen für eine gelingende Schnittstellenkoordination im Sinne eines Entlassmanagements. Kriterien für ein Entlassmanagement in der Kinder- und Jugendpsychiatrie existieren nicht. Ziel der Studie ASpeKT (Aussagen zu Schnittstellenkoordination bei psychisch erkrankten Kindern und Teens) war es, den Iststand von Schnittstellenmanagement anhand von Aussagen von Eltern zu erheben und Empfehlungen für ein Entlassmanagement abzuleiten.Zu zwei Zeitpunkten (T3 = 6 Monate, T4 = 12 Monate nach Entlassung) wurden Eltern (T3: n = 124, T4: n = 81) zu den erfolgten Hilfen und deren Koordination befragt.Eltern benennen, dass erreichbare poststationäre Hilfen für eine Stabilität nach stationärer Behandlung essenziell sind und einer guten Koordination bedürfen. Für eine gelingende Schnittstellenkoordination werden aus Sicht der Eltern benannt: vorhandene Case-Manager, frühzeitige Runde Tische, eine gute Übergabe an schulische Strukturen, nahtlose Anschlusstermine zur ambulanten Weiterbehandlung sowie Information zu Anlaufstellen und Behandlungsmöglichkeiten.Proaktive frühzeitige individuelle Koordination von Hilfen durch einen konstanten Ansprechpartner ist aus Sicht der betroffenen Familien für ein gutes Entlassmanagement essenziell.
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- 2020
14. Effect of managed transition on mental health outcomes for young people at the child–adult mental health service boundary : a randomised clinical trial
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Singh, S. P., Tuomainen, H., Bouliotis, G., Canaway, A., De Girolamo, G., Dieleman, G. C., Franić, T., Madan, J., Maras, A., McNicholas, F., Paul, M., Purper-Ouakil, D., Santosh, P., Schulze, U. M.E., Street, C., Tremmery, S., Verhulst, F. C., Wells, P., Wolke, D., Warwick, J., Tah, Priya, Griffin, James, Appleton, Rebecca, Heaney, Natalie, Lievesley, Kate, Mastroianni, Mathilde, Singh, Jatinder, Adams, Laura, Signorini, Giulia, Ferrari, Alessandro, Gheza, Elisa, Ferrari, Cecilia, Rivolta, Laura, Levi, Flavia, Cataldo, Maria, Manenti, Lidia, Morini, Giorgia, Pastore, Adriana, Stagni, Pamela, Toselli, Cecilia, Varvara, Pamela, Russet, Frédérick, Maurice, Virginie, Humbertclaude, Véronique, Bodegom, Larissa S.Van, Overbeek, Mathilde M., Gerritsen, Suzanne E., Saam, Melanie, Breuninger, Ulrike, Hendrickx, Gaëlle, The MILESTONE Consortium, and Child and Adolescent Psychiatry / Psychology
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Clinical trial ,Psychiatry and Mental health ,medicine.medical_specialty ,SDG 3 - Good Health and Well-being ,RJ ,medicine ,Psychiatry ,Psychology ,Mental health ,Applied Psychology ,Boundary (real estate) ,Mental health service - Abstract
BackgroundPoor transition planning contributes to discontinuity of care at the child–adult mental health service boundary (SB), adversely affecting mental health outcomes in young people (YP). The aim of the study was to determine whether managed transition (MT) improves mental health outcomes of YP reaching the child/adolescent mental health service (CAMHS) boundary compared with usual care (UC).MethodsA two-arm cluster-randomised trial (ISRCTN83240263 and NCT03013595) with clusters allocated 1:2 between MT and UC. Recruitment took place in 40 CAMHS (eight European countries) between October 2015 and December 2016. Eligible participants were CAMHS service users who were receiving treatment or had a diagnosed mental disorder, had an IQ ⩾ 70 and were within 1 year of reaching the SB. MT was a multi-component intervention that included CAMHS training, systematic identification of YP approaching SB, a structured assessment (Transition Readiness and Appropriateness Measure) and sharing of information between CAMHS and adult mental health services. The primary outcome was HoNOSCA (Health of the Nation Outcome Scale for Children and Adolescents) score 15-months post-entry to the trial.ResultsThe mean difference in HoNOSCA scores between the MT and UC arms at 15 months was −1.11 points (95% confidence interval −2.07 to −0.14, p = 0.03). The cost of delivering the intervention was relatively modest (€17–€65 per service user).ConclusionsMT led to improved mental health of YP after the SB but the magnitude of the effect was small. The intervention can be implemented at low cost and form part of planned and purposeful transitional care.
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- 2021
15. Interpenetrating polymer networks based on EVA copolymer and PMMA
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Schulze, U., Janke, A., Pompe, G., Meyer, E., Rätzsch, M., Kilian, H. -G., editor, Lagaly, G., editor, Wartewig, S., and Helmis, G.
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- 1992
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16. Ecological momentary intervention to reduce suicide risk among adolescents (EMIRA)
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Oexle, N, primary, Becker, T, additional, Boege, I, additional, Buschek, D, additional, Fegert, J, additional, Killian, R, additional, Noterdaeme, M, additional, Rassenhofer, M, additional, Ruesch, N, additional, and Schulze, U, additional
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- 2021
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17. Transgenerationale Effekte mütterlicher Angst: Mütterliche Ängstlichkeit und sozioemotionale Entwicklung von Vorschulkindern
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Künster, A.K., Ziegenhain, U., Schulze, U., Buchheim, A., von Wietersheim, H., Vicari, A., Peter, A., and Besier, T.
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- 2012
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18. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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Kolokathis F, Kostakou P, Lekakis J, Manolis A, Mantas I, Megalou A, Milkas A, Nanas J, Olympios CD, Patsilinakos S, Perperis A, Poulimenos L, Saloustros I, Tsioufis K, Tsorbatzoglou K, Vardas P, Zarifis I, Aguilar M, Arango JL, Borrayo NA, Corona V, Guerrero A, Guzman I, Haase F, De Krumbach L, Montenegro P, Munoz R, Munoz N, Paniagua A, Solares A, Vogel M, Anita S, Blazsek Z, Decsi K, Fulop T, Hangyal T, Hegedus V, Kalina A, Karakai H, Katona A, Kiss RG, Kovacs A, Laszlo Z, Lupkovics G, Medvegy M, Merkely B, Mihaly N, Nagy AC, Dékány JN, Nikoletta P, Noori E, Penzes J, Poor F, Sarszegi Z, Simay A, Simon J, Szakal I, Szatmarine V, Szocs A, Zilahi Z, Karsai XZ, Andersen K, Sigurdadottir E, Skuladottir F, Abdullakutty J, Abhaichand R, Abhyankar A, Agarwal DK, Aggarwal RK, Ahire N, Awasthi AK, Babu R, Bai A, Bali HK, Banker D, Bhadade S, Bisne V, Bohra P, Raghu C, Chauhan D, Chauhan H, Chavada J, Chaware G, Chella S, Chintala P, Dash D, Desai D, Devasia T, Dhanak R, Dobariya H, Dudhatra 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Y, Sakurada M, Sasaki S, Seki S, Shimomura H, Shinozaki T, Sugimoto N, Suzuki A, Taguchi S, Takahashi J, Takase S, Tanabe K, Tanaka A, Tani S, Tomioka J, Tsuboi H, Tsuji M, Tsujita K, Tsujiyama S, Umesu A, Yamada T, Yamaguchi E, Yamamoto H, Yamamoto T, Yamane M, Yanase T, Yasuoka S, Yasutake M, Yokoyama M, Yoshida M, Yoshimoto E, Yunoki C, Balode A, Dormidontova G, Flaksa I, Nagele-Luse I, Rancane G, Sime I, Bartuseviciene S, Cepinskiene L, Dobilas V, Grigaraviciene I, Marcinkeviciene J, Mazutavicius R, Miliuniene R, Motiejuniene R, Norkiene S, Norkute-Macijauske U, Rudys A, Slapikas R, Stonkute K, Strazdiene D, Tijuneliene E, Urbonas G, Vanagiene S, Viezelis M, Aguilar M, Arenas Leon JL, Bayram E, Carrillo J, Davalos C, De Los Rios M, Delgadillo T, Hernández N, Leon S, Mendoza N, Muñoz W, Ramos G, Anneveldt A, Bakker H, Brouwer M, Bunschoten P, De Boer P, De Jong C, De Vos A, Den Hartog F, Doesborg L, Dommerholt R, Drost I, Ellenbroek D, Engelen W, Folkeringa RJ, Hamer BJB, Herrman JP, Hoogslag PAM, Jansen M, Jerzewski A, Joosten C, Kalkman C, Kietselaer B, Kok M, Kooiman E, Kose V, Lardinois R, Lenderink T, Lok DJA, Lousberg A, Meijlis P, Mulder R, Singerling M, Smeele F, Stroes E, Swart HP, Ten Holt W, Van Der Wal M, Van Der Zwaan C, Van Kempen WW, Van Maarseveen M, Van Stein I, Viergever EP, Visseren FLJ, Voors C, Nugteren SKZ, Ata B, Berulfsen A, Rønnevik TD, Dickstein K, Furuseth B, Grundtvig M, Hansen H, Hofsoey K, Høivik HO, Bøen RH, Hurtig U, Pettersen KI, Johansen E, Kleve R, Kolleroy C, Moen S, Nilsen V, Norin V, Otterstad JE, Risberg K, Rønnevik P, Sirnes PA, Skjelvan G, Strand S, Szacinski G, Vegsundvåg J, Alcalde JM, Gomez Sanchez J, Rodriguez J, Rodriguez A, Zena N, Baszak J, Cymerman K, Czerski T, Fratczak M, Jaguszewska G, Kawka-Urbanek T, Koba M, Kopaczewski J, Kopczyńska M, Laniec M, Lysek R, Sciborski R, Szpajer M, Torun A, Wujkowski M, Zielinski M, Ahn Y, Baek C, Bang SA, Chang K, Choi AJ, Han S, Hong T, Hyun K, Kim M, Kim KS, Kim B, Lee SH, 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Skopets I, Skuratova M, Smolenskaya O, Solovev O, Trofimov V, Vasiliev M, Vezikova N, Vozzhaev A, Yakushin S, Zadionchenko V, Apostolovic S, Adjic NC, Ilic I, Ilic S, Nikolic L, Pupic L, Stokuca-Korac N, Antalik L, Bugan V, Csala L, Dokupilova A, Dzupina A, Forgon T, Fulop P, Gonsorcik J, Gyorgyova E, Holoubek D, Horvat P, Kamensky G, Kolikova V, Krupciakova B, Lenner E, Lennerova J, Lukac J, Majercak I, Mancikova I, Micko K, Nociar J, Pales J, Palka J Jr, Poliacik P, Ruffini L, Sabo L, Skubova K, Slanina M, Smik R, Srdos V, Stitova M, Stofkova D, Strbova J, Such S, Toth P, Urgeova L, Vinanska D, Zareczky P, Flezar M, Kovacic D, Marcun R, Zagozen P, Bolsmann C, Commerford P, Conradie C, Dawood SY, Decsi KL, Ebrahim I, Henley L, Horak A, Kapp I, Komati S, Lock E, Maboyi S, Makotoko E, Manga P, Page A, Ramdas S, Ranjith N, Roos J, Talliard C, Ajax K, Al-Khalili F, Assarsson E, Bergholtz T, Blom KB, Boman K, Boström PÅ, Curiac D, Jensen ED, Dahlen G, Davidsson K, Duckert A, Hansson A, Härstedt N, Henriksson A, Olsson GH, Johansson K, Jonsson JE, Knutsson A, Lindholm CJ, Liu B, Lönnberg I, Lundqvist M, Mellberg L, Moodh J, Mooe T, Olofsson M, Risenfors M, Rönndahl M, Sundelin R, Suorra I, Torgersruud M, Torstensson I, Chang KC, Chen CP, Chen ZC, Chen MH, Cheng SM, Cheng JJ, Fang CY, Ho CJ, Hsieh IC, Huang PH, Huang A, Hwang JJ, Kuo JY, Lai WT, Lee SC, Li YH, Lin T, Liu HM, Tsai MC, Tsao HM, Tzong L, Ueng KC, Wang YL, Wang HC, Wang CP, Yang CC, Abaci F, Birdane A, Yilmaz MB, Asim Oktay AO, Kan G, Koldas N, Ozcan IT, Sahin M, Sahin T, Saka B, Tekten T, Ucar N, Uresin S, Yigit Z, Arif I, Bakhai A, Baksi A, Blagdon M, Brickman T, Brown N, Burton M, Burton J, Chaggar S, Chung A, Collier D, Covell W, Crawford G, Davies N, Davies M, Dayer M, Doughty A, Duff J, Dwenger E, Fisher J, Fitzpatrick L, Garner K, Glover J, Haughton G, Ilsley M, Ivan P, Voyzey EJ, Keenan S, Kelt T, Knight J, Kondagunta V, Lang C, Lee K, Lim L, Macdonald J, Mathew A, Mckenzie A, Mckibbin A, Michalska A, Pagett K, Pogson A, Price R, Price D, Procter K, Pye M, Redfearn H, Rewbury J, Ryding A, Sattar N, Sharp A, Shaw P, Simpson H, Smith W, Squire I, Storey R, Teenan M, Thomas H, Townend J, Trevelyan J, Wakeling J, Walukiewicz P, Wilkinson S, Zaman A, Acevedo L, Benton J, Abbate A, Aboufakher R, Acampora M, Acampora D, Aceto L, Acevedo B, Acheatel R, Adams M, Adams A, Ahmad I, Ahmed SH, Aish B, Akyea-Djamson A, Al Joundi T, Alcide P, Alfieri A, Alfonso T, Alfrey A, Allen J, Alllison DC, Almaliky T, Amos A, Angiolillo D, Antolick A, Ara M, Aragorn L, Arevalo S, Armas E, Arthur A, Asafu-Adjaye N, Ashcom T, Ashford M, Aslam A, Ather N, Atieh M, Aull L, Ayala M, Azizad M, Backer T, Baehl S, Bailey S, Bair S, Baker C, Ballmajo M, Pieretti HB, Baquero A, Barnett S, Baron S, Bartkowiak A, Bashir K, Beall K, Beauregard LA, Sarah S, Beckett L, Belejchak P, Bendelow T, Bender D, Benjamin S, Berdoff R, Berger V, Bergeron P, Berk M, Bernstein M, Binns Y, Bitzer V, Blahey M, Bloch S, Bluemel J, Boffetti P, Boley K, Bonner J, Boudreaux R, Boulanger K, Bradley A, Bramlet D, Bredlau C, Briggs S, Brousalis L, Brown S, Brown C, Buchannan C, Burke W, Burley T, Burton C, Burtt D, Byars W, Caballero-Valiente B, Carr K, Halliwell TC, Castillo J, Cei L, Cerda L, Chambers J, Chamblee T, Chattin W, Chee L, Chen YC, Cherlin R, Cheung D, Chiodi L, Christensen L, Christenson S, Cislowski D, Clavier-Firmin C, Colfer H, Colvin T, Cosgrove N, Covert C, Cox B, Cox R, Craig W, Crandall L, Crepps K, Cromer M, Cruz H, Cruz H, Cruz M, Cucher F, Damron M, Dave K, Dave B, Davis M, Davis B, Dawkins-Hughes S, Dean J, Debnam S, Defosse C, Dehning M, Dela Llana A, Dellorso M, Denham D, Desalle D, Dettmer M, Dhawan M, Diago M, Dicken T, Diederich C, Diederich M, Diehl R, Digangi D, Diller P, Dimattia M, Dodds G, Doggett J, Donahue K, Doughty L, Dragutksy B, Dreese M, Dunhurst F, Dunn D, Dutka C, Earl J, Eaton C, Eaves W, Ebeling K, Eder F, Edgerton L, Edillo C, Edwards J, Edwards T, Einhorn D, El Hafi S, Ellis M, Erickson B, Ervin W, Eskridge L, Fail P, Falcon D, Fang C, Fattal P, Fawson A, Felix L, Ferdinand K, Fien E, Fintel D, Firek C, Fitz-Patrick D, Flores E, Flores E, Flores H, Floro T, Forker A, Foster M, Foucauld J, Lehman KF, Fox B, Francoeur L, Frandsen B, Frandsen B, Frivold G, Fruchter G, Fullerton D, Gabriel J, Gacioch G, Garas S, Garcia N, Garcia Rinaldi R, Garcia-Fragoso V, Garcia-Portela M, Gelb R, George F, Ghali J, Gilbert J, Gilley J, Glancy R, Goff R, Goldberg N, Gonzales D, Gonzales V, Gonzalez E, Gorges R, Gould R, Grabeau R, Grable M, Graham JA, Graif J, Green E, Greener R, Greenway F, Grieshaber V, Griffin S, Gros C, Gudipati RVC, Guillinta P, Gupta V, Gutmann J, Gwyn M, El Hachem M, Hage F, Hageman T, Haidar A, Hakas J, Haldis T, Hall L, Hall C, Hall S, Halpern S, Hamud-Socoro A, Hardee L, Harrell W, Harrington A, Hartwell J, Hasan F, Hattler B, Haught H, Haynes E, Haywood A, Heaney L, Hecht J, Hernandez I, Herzog W, Hess E, Hill H, Hilton T, Hinderaker P, Hodnett P, Hoffman M, Hogan C, Holmes Z, Rees DH, Hotchkiss D, Huang P, Humbert J, Hutchens E, Iachini K, Ibarra M, Igbokidi O, Ilahi T, Imbrognio M, Ipp E, Iteld B, Jacques G, Jafri A, Jafry B, Jardula M, Jefferson D, Jenkins R, Johnson E, Johnson J, Jones S, Kawahara M, Kelehan S, Kelly R, Kendall T, Kereiakes D, Khan M, Khan S, Kick J, Kimmel M, King T, King A, Kirkland S, Kissel S, Kitchens D, Klein P, Klugherz B, Korban E, Koren M, Korte M, Kostis J, Kotek L, Kozak M, Kreutter F, Kusnick B, Labovitz R, Lail J, Lamance J, Lamas G, Lambert J, Lambert C, Landzberg J, Langdon J, Lavoie W, Ledger G, Lee T, Lee K, Lehman R, Leimbach W, Lennard M, Lepor N, Lester F, Levin P, Levinson L, Lewis D, Lillo J, Link L, Long C, Longaker R, Lorch G, Lucksinger G, Lynd S, Rhudy JM, Madder R, Magness K, Maheshwari A, Alan A, Malek M, Maletz L, Malhotra V, Malhotra S, Mandviwala M, Mani CK, Manuel J, Marchelletta N, Marshall L, Marsters M, Martin L, Martinez E, Mavromatis K, Maynard R, Mays M, Mays B, Mbulaiteye A, Mcalister R, Mccoy C, Mccrary D Jr, Mccullough-O'Brien H, Mcdonald M, Mcgill J, Mcgrew F, Mckenzie C, Mclaurin B, Mclellan BA, Mcneil D, Mcneill R, Mehrle A, Melbie K, Melliza T, Messina T, Meyer R, Michel K, Mikdadi G, Miller C, Miller R, Miller A, Miller G, Miller W, Mitchell J, Moats DJR, Mody F, Moffat J, Molk B, Molter D, Monroe T, Montero H, Montgomery R, Mookherjee D, Moran J, Moriarty P, Morrison J, Morton D, Moshayedi P, Mosley J, Moustafa M, Munshi K, Murray A, Mustafa J, Nadar V, Naidu R, Nalley J, Navy S, Neil L, Neutel JM, Niblack P, Nicely V, Nicolai M, Nijmeh G, Nikas A, Nikyar A, Nixon S, Norman L, Noto G, Nour K, Nugent A, Ocman B, Odegard A, Olsen S, Ortiz-Carrasquillo R, Ossino N, Paez H, Palchick B, Paliwal Y, Pannell R, Parfait V, Partridge J, Patel B, Patel R, Patel M, Patel S, Paysor C, Pena A, Pereira S, Perez M, Perez A, Perkins H, Perry B, Peters P, Phillippi C, Phillips A, Phillips A, Piacente R, Pintado M, Pish R, Pitt W, Poling T, Pomposini D, Poock J, Potts J, Poudrier R, Prior J, Pritchard C, Purighalla R, Quddusi K, Quinones J, Quinton D, Radin M, Radojcsics B, Rajput B, Rama B, Ramos M, Rauch R, Raynes K, Reber AM, Reddy J, Reeves M, Reilly K, Renaud K, Resnick H, Reyes R, Richardson M, Riethof M, Riser J, Rodero M, Rodriguez Araya E, Roper L, Rozeman P, Ruder D, Runquist L, Sack G, Saint-Jacques H, Salfity M, Sall N, Sam K, Samal A, Sanchez D, Santiago J Jr, Savignano C, Saylor R, Scheffel M, Schifferdecker B, Schindler E, Schneider P, Schneider R, Schnitzler R, Schrager B, Schwartz A, Scott R, Seals A, Shah AV, Shah A, Shatsky K, Shayani S, Shealy N, Sheets L, Shelley J, Shepard P, Shetty S, Silver K, Simon M, Singh K, Singh N, Sizemore BC, Skatrud L, Slayton C, Slimak V, Sloane G, Smallwood B, Smith P, Smith M, Smith T, Smith G, Smith B, Smith W, Smith M, Smith J, Smith J, Soca Y, Sofley C, Sopko K, Sosa-Padilla M, Sotolongo R, Sprinkle B, Srivastava S, Starzec M, Steinhoff J, Stelly L, Stinson J, Stoddard M, Stoltz S, Stone B, Stover T, Strain J, Strugatsky S, Stys T, Suleman A, Sullivan P, Tamez W, Tandon N, Teltser M, Terry PS, Terry K, Tessmar C, Thekkoott D, Thomas D, Thomas DM, Thompson E, Thompson J, Thornton A, Tjaden T, Tobias C, Topper J, Tran A, Treasure C, Trenkamp P, Trevino M, Tsou L, Tuholske C, Uy W, Vahtel M, Vaid B, Valenzuela M, Vance A, Vandam J, Vanhecke T, Vanness WC III, Vargas R, Vaz S, Vazquez Tanus J, Veerina K, Vega J, Vento A, Vijay N, Voelker F, Vogt E, Vold D, Vora K, Wade RD, Wadell C, Waksman R, Walker K, Walker K, Wallace K, Warren M, Washam M, Watson B, Webel R, Wells T, West M, Whitaker J, White J, White C, White A, White A, Wilhoit G, Wilkins M, Willingham K, Wilson S, Wilson V, Wise J, Woodall S, Woods A, Wright J, Wu J, Xu ZJ, Yarows S, Young A, Younis L, Zarate J, Zebrack J, Zhang W, Zieve F, Zineldine A, Ridker, P. M., Everett, B. M., Thuren, T., Macfadyen, J. G., Chang, W. H., Ballantyne, C., FONSECA E PIRES, CARLOS EDUARDO, Nicolau, J., Koenig, W., Anker, S. D., Kastelein, J. J. P., Cornel, J. H., Pais, P., Pella, D., Genest, J., Cifkova, R., Lorenzatti, A., Forster, T., Kobalava, Z., Vida-Simiti, L., Flather, M., Shimokawa, H., Ogawa, H., Dellborg, M., Rossi, P. R. F., Troquay, R. P. T., Libby, P., Glynn R., J, CANTOS Trial, Group, Perrone, Filardi, P, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ACS - Atherosclerosis & ischemic syndromes
- Subjects
0301 basic medicine ,030204 cardiovascular system & hematology ,law.invention ,0302 clinical medicine ,c-reactive protein ,Randomized controlled trial ,law ,Cardiovascular Disease ,middle aged ,double-blind method ,antibodies ,Myocardial infarction ,humans ,Stroke ,interleukin-1beta ,biology ,Antibodies, Monoclonal ,drug ,General Medicine ,Lipid ,Aged ,anti-inflammatory agents ,monoclonal ,humanized ,atherosclerosis ,cardiovascular diseases ,dose-response relationship ,female ,incidence ,infections ,lipids ,male ,myocardial infarction ,neutropenia ,secondary prevention ,stroke ,Anti-Inflammatory Agent ,aged ,Editorial ,Atherosclerosi ,Monoclonal ,Human ,medicine.drug ,medicine.medical_specialty ,Neutropenia ,Antibodies, Monoclonal, Humanized ,Infections ,Placebo ,antibodies, monoclonal ,dose-response relationship, drug ,infection ,medicine (all) ,03 medical and health sciences ,Internal medicine ,medicine ,Dose-Response Relationship, Drug ,business.industry ,Antiinflammatory Therapy, Canakinumab, for Atherosclerotic Disease ,C-reactive protein ,medicine.disease ,Surgery ,Canakinumab ,030104 developmental biology ,biology.protein ,business - Abstract
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.)
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- 2017
19. Trait anxiety in children and adolescents with anorexia nervosa
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Schulze, U. M. E., Calame, S., Keller, F., and Mehler-Wex, C.
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- 2009
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20. Essstörungen und Typ-1-Diabetes im Kindes- und Jugendalter: Übersicht zur Komorbidität
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Schulze, U., Holl, R.W., and Goldbeck, L.
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- 2008
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21. Atomoxetin bei Patienten mit Klinefelter-Syndrom und hyperkinetischer Störung des Sozialverhaltens
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Schubert, S., Fegert, J.M., and Schulze, U.
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- 2007
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22. Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures
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Santosh, P., Adams, L, Fiori, F., Davidovic, N., de Girolamo, G., Dieleman, G.C. (Gwen), Franic, T., Heaney, N., Lievesley, K., Madan, J., Maras, A. (Athanasios), Mastroianni, M., McNicholas, F., Paul, M., Purper-Ouakil, D., Sagar-Ouriaghli, I., Schulze, U., Signorini, G., Street, C., Tah, P., Tremmery, S., Tuomainen, H., Verhulst, F.C. (Frank), Warwick, J., Wolke, D., Singh, J, Singh, S.P. (Simar Pal), Santosh, P., Adams, L, Fiori, F., Davidovic, N., de Girolamo, G., Dieleman, G.C. (Gwen), Franic, T., Heaney, N., Lievesley, K., Madan, J., Maras, A. (Athanasios), Mastroianni, M., McNicholas, F., Paul, M., Purper-Ouakil, D., Sagar-Ouriaghli, I., Schulze, U., Signorini, G., Street, C., Tah, P., Tremmery, S., Tuomainen, H., Verhulst, F.C. (Frank), Warwick, J., Wolke, D., Singh, J, and Singh, S.P. (Simar Pal)
- Abstract
Background: Mental health disorders in the child and adolescent population are a pressing public health concern. Despite the high prevalenc
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- 2020
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23. Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MILESTONE) study
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Santosh, P. (Paramala), Singh, J. (Jatinder), Adams, L. (Laura), Mastroianni, M. (Mathilde), Heaney, N. (Natalie), Lievesley, K. (Kate), Sagar-Ouriaghli, I. (Ilyas), Allibrio, G. (Giovanni), Appleton, R. (Rebecca), Davidović, N. (Nikolina), de Girolamo, G. (Giovanni), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Franić, T. (Tomislav), Gatherer, C. (Charlotte), Gerritsen, S.E. (Suzanne), Gheza, E. (Elisa), Madan, J. (Jason), Manenti, L. (Lidia), Maras, A. (Athanasios), Margari, F. (Francesco), McNicholas, F. (Fiona), Pastore, A. (Adriana), Paul, M. (Moli), Purper-Ouakil, D. (Diane), Rinaldi, F. (Francesco), Sakar, V. (Vehbi), Schulze, U. (Ulrike), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tremmery, S. (Sabine), Tuffrey, A. (Amanda), Tuomainen, H. (Helena), Verhulst, F.C. (Frank), Warwick, J. (Jane), Wilson, A. (Anna), Wolke, D. (Dieter), Fiori, F. (Federico), Singh, S.P. (Swaran), Santosh, P. (Paramala), Singh, J. (Jatinder), Adams, L. (Laura), Mastroianni, M. (Mathilde), Heaney, N. (Natalie), Lievesley, K. (Kate), Sagar-Ouriaghli, I. (Ilyas), Allibrio, G. (Giovanni), Appleton, R. (Rebecca), Davidović, N. (Nikolina), de Girolamo, G. (Giovanni), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Franić, T. (Tomislav), Gatherer, C. (Charlotte), Gerritsen, S.E. (Suzanne), Gheza, E. (Elisa), Madan, J. (Jason), Manenti, L. (Lidia), Maras, A. (Athanasios), Margari, F. (Francesco), McNicholas, F. (Fiona), Pastore, A. (Adriana), Paul, M. (Moli), Purper-Ouakil, D. (Diane), Rinaldi, F. (Francesco), Sakar, V. (Vehbi), Schulze, U. (Ulrike), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tremmery, S. (Sabine), Tuffrey, A. (Amanda), Tuomainen, H. (Helena), Verhulst, F.C. (Frank), Warwick, J. (Jane), Wilson, A. (Anna), Wolke, D. (Dieter), Fiori, F. (Federico), and Singh, S.P. (Swaran)
- Abstract
OBJECTIVE: Young people moving from child and adolescent mental health services (CAMHS) to adult mental health services (AMHS) are faced with significant challenges. To improve this state of affairs, there needs to be a recognition of the problem and initiatives and an urgent requirement for appropriate tools for measuring readiness and outcomes at the transfer boundary (16-18 years of age in Europe). The objective of this study was to develop and
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- 2020
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24. Validation of the Transition Readiness and Appropriateness Measure (TRAM) for the Managing the Link and Strengthening Transition from Child to Adult Mental Healthcare in Europe (MILESTONE) study
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Santosh, P, Singh, J, Adams, L, Mastroianni, M, Heaney, N, Lievesley, K, Sagar-Ouriaghli, I, Allibrio, G, Appleton, R, Davidovic, N, de Girolamo, G, Dieleman, Gwen, Dodig-Curkovic, K, Franic, T, Gatherer, C, Gerritsen, Suzanne, Gheza, E, Madan, J, Manenti, L, Maras, Athanasios, Margari, F, McNicholas, F, Pastore, A, Paul, M, Purper-Ouakil, D, Rinaldi, F, Sakar, V, Schulze, U, Signorini, G, Street, C, Tah, P, Tremmery, S, Tuffrey, A, Tuomainen, H, Verhulst, Frank, Warwick, J, Wilson, A, Wolke, D, Fiori, F, Singh, S, Santosh, P, Singh, J, Adams, L, Mastroianni, M, Heaney, N, Lievesley, K, Sagar-Ouriaghli, I, Allibrio, G, Appleton, R, Davidovic, N, de Girolamo, G, Dieleman, Gwen, Dodig-Curkovic, K, Franic, T, Gatherer, C, Gerritsen, Suzanne, Gheza, E, Madan, J, Manenti, L, Maras, Athanasios, Margari, F, McNicholas, F, Pastore, A, Paul, M, Purper-Ouakil, D, Rinaldi, F, Sakar, V, Schulze, U, Signorini, G, Street, C, Tah, P, Tremmery, S, Tuffrey, A, Tuomainen, H, Verhulst, Frank, Warwick, J, Wilson, A, Wolke, D, Fiori, F, and Singh, S
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- 2020
25. Protocol for the development and validation procedure of the managing the link and strengthening transition from child to adult mental health care (MILESTONE) suite of measures
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Santosh, P, Adams, L, Fiori, F, Davidovic, N, de Girolamo, G, Dieleman, Gwen, Franic, T, Heaney, N, Lievesley, K, Madan, J, Maras, Athanasios, Mastroianni, M, McNicholas, F, Paul, M, Purper-Ouakil, D, Sagar-Ouriaghli, I, Schulze, U, Signorini, G, Street, C, Tah, P, Tremmery, S, Tuomainen, H, Verhulst, Frank, Warwick, J, Wolke, D, Singh, J, Pal Singh, Simar, Santosh, P, Adams, L, Fiori, F, Davidovic, N, de Girolamo, G, Dieleman, Gwen, Franic, T, Heaney, N, Lievesley, K, Madan, J, Maras, Athanasios, Mastroianni, M, McNicholas, F, Paul, M, Purper-Ouakil, D, Sagar-Ouriaghli, I, Schulze, U, Signorini, G, Street, C, Tah, P, Tremmery, S, Tuomainen, H, Verhulst, Frank, Warwick, J, Wolke, D, Singh, J, and Pal Singh, Simar
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- 2020
26. Olanzapine in children and adolescents with chronic anorexia nervosa. A study of five cases
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Mehler, C., Wewetzer, Ch., Schulze, U., Warnke, A., Theisen, F., and Dittmann, R. W.
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- 2001
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27. Trefoil Factor Family Peptide 3 at the Ocular Surface. A Promising Therapeutic Candidate for Patients with Dry Eye Syndrome?
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Schulze, U., primary, Sel, S., additional, and Paulsen, F.P., additional
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- 2010
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28. Human dendritic cells transfected with either RNA or DNA encoding influenza matrix protein M1 differ in their ability to stimulate cytotoxic T lymphocytes
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Strobel, I, Berchtold, S, Götze, A, Schulze, U, Schuler, G, and Steinkasserer, A
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- 2000
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29. Training of adult psychiatrists and child and adolescent psychiatrists in europe
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Singh, S.P. (Swaran), Madan, J. (Jason), Warwick, J. (Jane), Wolke, D. (Dieter), Appleton, R. (Rebecca), Canaway, A. (Alastair), Griffin, J.D. (James), De Girolamo, G. (Giovanni), Santosh, P. (Paramala), Sagar-Ouriaghli, I. (Ilyas), Heaney, N. (Natalie), Maurice, V. (Virginie), Van Bodegom, L. (Larissa), Overbeek, M. (Mathilde), Kooymans, E. (Esther), Schulze, U. (Ulrike), Saam, M. (Melanie), Breuninger, U. (Ulrike), Gronostaj, A. (Aleksandra), Franić, T. (Tomislav), Davidović, N. (Nikolina), Verhulst, F.C. (Frank), Gerritsen, S.E. (Suzanne), Lievesley, K. (Kate), Tuffrey, A. (Amanda), Wilson, A. (Anna), Gatherer, C. (Charlotte), Walker, L. (Leanne), Russet, F. (Frederick), Humbertclaude, V. (Veronique), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Hendrickx, G. (Gaelle), Kovač, V. (Vlatka), McNicholas, F. (Fiona), Maras, A. (Athanasios), Paramala, S. (Santosh), Paul, M. (Moli), Schulze, U.M.E. (Ulrike M. E.), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tuomainen, H. (Helena), Singh, S.P. (Swaran P.), Tremmery, S. (Sabine), Purper-Ouakil, D. (Diane), Singh, S.P. (Swaran), Madan, J. (Jason), Warwick, J. (Jane), Wolke, D. (Dieter), Appleton, R. (Rebecca), Canaway, A. (Alastair), Griffin, J.D. (James), De Girolamo, G. (Giovanni), Santosh, P. (Paramala), Sagar-Ouriaghli, I. (Ilyas), Heaney, N. (Natalie), Maurice, V. (Virginie), Van Bodegom, L. (Larissa), Overbeek, M. (Mathilde), Kooymans, E. (Esther), Schulze, U. (Ulrike), Saam, M. (Melanie), Breuninger, U. (Ulrike), Gronostaj, A. (Aleksandra), Franić, T. (Tomislav), Davidović, N. (Nikolina), Verhulst, F.C. (Frank), Gerritsen, S.E. (Suzanne), Lievesley, K. (Kate), Tuffrey, A. (Amanda), Wilson, A. (Anna), Gatherer, C. (Charlotte), Walker, L. (Leanne), Russet, F. (Frederick), Humbertclaude, V. (Veronique), Dieleman, G.C. (Gwen), Dodig-Ćurković, K. (Katarina), Hendrickx, G. (Gaelle), Kovač, V. (Vlatka), McNicholas, F. (Fiona), Maras, A. (Athanasios), Paramala, S. (Santosh), Paul, M. (Moli), Schulze, U.M.E. (Ulrike M. E.), Signorini, G. (Giulia), Street, C. (Cathy), Tah, P. (Priya), Tuomainen, H. (Helena), Singh, S.P. (Swaran P.), Tremmery, S. (Sabine), and Purper-Ouakil, D. (Diane)
- Abstract
Background: Profound clinical, conceptual and ideological differences between child and adult mental health service models contribute to transition-related discontinuity of care. Many of these may be related to psychiatry training. Methods: A systematic review on General Adult Psychiatry (GAP) and Child and Adult Psychiatry (CAP) training in Europe, with a particular focus on transition as a theme in GAP and CAP training. Results: Thirty-four full-papers, six abstracts and seven additional full text documents were identified. Important variations between countries were found across several domains including assessment of trainees, clinical and educational supervision, psychotherapy training and continuing medical education. Three models of training were identified: i) a generalist common training programme; ii) totally separate training programmes; iii) mixed types. Only two national training programs (UK and Ireland) were identified to have addressed transition as a topic, both involving CAP exclusively. Conclusion: Three models of training in GAP and CAP across Europe are identified, suggesting that the harmonization is not yet realised and a possible barrier to improving transitional care. Training in transition has only recently been considered. It is timely, topical and important to develop evidence-based training approaches on transitional care across Europe into both CAP and GAP training.
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- 2019
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30. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): Background, rationale and methodology
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Tuomainen, H. (H.), Schulze, U. (U.), Warwick, J. (J.), Paul, M. (M.), Dieleman, G.C. (Gwen), Franić, T. (T.), Madan, J. (J.), Maras, A. (Athanasios), McNicholas, F. (F.), Purper-Ouakil, D. (D.), Santosh, P. (Paramala), Signorini, G. (G.), Street, C. (C.), Tremmery, S. (S.), Verhulst, F.C. (Frank), Wolke, D. (D.), Sartorius, N. (Norman), McGorry, P. (Pat), Davis, M. (Maryann), Mihai, A. (Adriana), Singh, S.P. (Swaran), Tuomainen, H. (H.), Schulze, U. (U.), Warwick, J. (J.), Paul, M. (M.), Dieleman, G.C. (Gwen), Franić, T. (T.), Madan, J. (J.), Maras, A. (Athanasios), McNicholas, F. (F.), Purper-Ouakil, D. (D.), Santosh, P. (Paramala), Signorini, G. (G.), Street, C. (C.), Tremmery, S. (S.), Verhulst, F.C. (Frank), Wolke, D. (D.), Sartorius, N. (Norman), McGorry, P. (Pat), Davis, M. (Maryann), Mihai, A. (Adriana), and Singh, S.P. (Swaran)
- Abstract
Background: Transition from distinct Child and Adolescent Mental Health (CAMHS) to Adult Mental Health Services (AMHS) is beset with multitude of problems affecting continuity of care for young people with mental health needs. Transition-related discontinuity of care is a major health, socioeconomic and societal challenge globally. The overall aim of the Managing the Link and Strengthening Transition from Child to Adult Mental Health Care in Europe (MILESTONE) project (2014-19) is to improve transition from CAMHS to AMHS in diverse healthcare settings across Europe. MILESTONE focuses on current service provision in Europe, new transition-related measures, long term outcomes of young people leaving CAMHS, improving transitional care through 'managed transition', ethics of transitioning and the training of health care professionals. Methods: Data will be collected via systematic literature reviews, pan-European surveys, and focus groups with service providers, users and carers, and members of youth advocacy and mental health advocacy groups. A prospective cohort study will be conducted with a nested cluster randomised controlled trial in eight European Union (EU) countries (Belgium, Croatia, France, Germany, Ireland, Italy, Netherlands, UK) involving over 1000 CAMHS users, their carers, and clinicians. Discussion: Improving transitional care can facilitate not only recovery but also mental health promotion and mental illness prevention for young people. MILESTONE will provide evidence of the organisational structures and processes influencing transition at the service interface across differing healthcare models in Europe and longitudinal outcomes for young people leaving CAMHS, solutions for improving transitional care in a cost-effective manner, training modules for clinicians, and commissioning and policy guidelines for service providers and policy makers.
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- 2018
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31. Managing the link and strengthening transition from child to adult mental health Care in Europe (MILESTONE): background, rationale and methodology
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Tuomainen, H, Schulze, U, Warwick, J, Paul, M, Dieleman, GC, Franic, T, Madan, J, Maras, A, McNicholas, F, Purper-Ouakil, D, Santosh, P, Signorini, G, Street, C, Tremmery, S, Verhulst, FC, Wolke, D, Singh, SP, Tuomainen, H, Schulze, U, Warwick, J, Paul, M, Dieleman, GC, Franic, T, Madan, J, Maras, A, McNicholas, F, Purper-Ouakil, D, Santosh, P, Signorini, G, Street, C, Tremmery, S, Verhulst, FC, Wolke, D, and Singh, SP
- Abstract
BACKGROUND: Transition from distinct Child and Adolescent Mental Health (CAMHS) to Adult Mental Health Services (AMHS) is beset with multitude of problems affecting continuity of care for young people with mental health needs. Transition-related discontinuity of care is a major health, socioeconomic and societal challenge globally. The overall aim of the Managing the Link and Strengthening Transition from Child to Adult Mental Health Care in Europe (MILESTONE) project (2014-19) is to improve transition from CAMHS to AMHS in diverse healthcare settings across Europe. MILESTONE focuses on current service provision in Europe, new transition-related measures, long term outcomes of young people leaving CAMHS, improving transitional care through 'managed transition', ethics of transitioning and the training of health care professionals. METHODS: Data will be collected via systematic literature reviews, pan-European surveys, and focus groups with service providers, users and carers, and members of youth advocacy and mental health advocacy groups. A prospective cohort study will be conducted with a nested cluster randomised controlled trial in eight European Union (EU) countries (Belgium, Croatia, France, Germany, Ireland, Italy, Netherlands, UK) involving over 1000 CAMHS users, their carers, and clinicians. DISCUSSION: Improving transitional care can facilitate not only recovery but also mental health promotion and mental illness prevention for young people. MILESTONE will provide evidence of the organisational structures and processes influencing transition at the service interface across differing healthcare models in Europe and longitudinal outcomes for young people leaving CAMHS, solutions for improving transitional care in a cost-effective manner, training modules for clinicians, and commissioning and policy guidelines for service providers and policy makers. TRIAL REGISTRATION: "MILESTONE study" registration: ISRCTN ISRCTN83240263 Registered 23 July 2015; ClinicalTri
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- 2018
32. Pflegeberatung im Fokus – Zu Typen und Wirksamkeit pflegeberaterischen Handelns im Gesundheitswesen
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Vazirabad, SK, Terjung, A, and Schulze, U
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ddc: 610 ,610 Medical sciences ,Medicine - Abstract
Hintergrund: Das vom Bundesministerium für Bildung und Forschung geförderte Projekt „OPEN – Interkulturelle Öffnung in der Pflegeberatung“ fokussiert die Entwicklung, Erprobung und wissenschaftliche Evaluation sozialraumspezifischer Ansätze der Pflegeberatung,[zum vollständigen Text gelangen Sie über die oben angegebene URL], 16. Deutscher Kongress für Versorgungsforschung (DKVF)
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- 2017
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33. Characterisation of radiation behaviour of polyethylene/polymethacrylates interpenetrating polymer networks
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Pionteck, J, Hu, J, Pompe, G, Albrecht, V, Schulze, U, and Borsig, E
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- 2000
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34. Development and psychometric properties of the "Suicidality: Treatment Occurring in Paediatrics (STOP) Risk and Resilience Factors Scales" in adolescents.
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Rodríguez-Quiroga, A., Flamarique, I., Castro-Fornieles, J., Lievesley, K., Buitelaar, J. K., Coghill, D., Díaz-Caneja, C. M., Dittmann, R. W., Gupta, A., Hoekstra, P. J., Kehrmann, L., Llorente, C., Purper-Ouakil, D., Schulze, U. M. E., Zuddas, A., Sala, R., Singh, J., Fiori, F., Arango, C., and Santosh, Paramala
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ANXIETY ,CAREGIVERS ,COGNITIVE testing ,STATISTICAL correlation ,MENTAL depression ,EXPERIMENTAL design ,FACTOR analysis ,FOCUS groups ,INTERPERSONAL relations ,RESEARCH methodology ,PARENTS ,PHYSICIANS ,PSYCHOMETRICS ,RESEARCH evaluation ,PSYCHOLOGICAL resilience ,RISK assessment ,SUBSTANCE abuse ,STATISTICAL reliability ,SUICIDAL ideation ,INTER-observer reliability ,MULTITRAIT multimethod techniques ,RESEARCH methodology evaluation ,DISEASE complications ,ADOLESCENCE - Abstract
Suicidality in the child and adolescent population is a major public health concern. There is, however, a lack of developmentally sensitive valid and reliable instruments that can capture data on risk, and clinical and psychosocial mediators of suicidality in young people. In this study, we aimed to develop and assess the validity of instruments evaluating the psychosocial risk and protective factors for suicidal behaviours in the adolescent population. In Phase 1, based on a systematic literature review of suicidality, focus groups, and expert panel advice, the risk factors and protective factors (resilience factors) were identified and the adolescent, parent, and clinician versions of the STOP-Suicidality Risk Factors Scale (STOP-SRiFS) and the Resilience Factors Scale (STOP-SReFS) were developed. Phase 2 involved instrument validation and comprised of two samples (Sample 1 and 2). Sample 1 consisted of 87 adolescents, their parents/carers, and clinicians from the various participating centres, and Sample 2 consisted of three sub-samples: adolescents (n = 259) who completed STOP-SRiFS and/or the STOP-SReFS scales, parents (n = 213) who completed one or both of the scales, and the clinicians who completed the scales (n = 254). The STOP-SRiFS demonstrated a good construct validity—the Cronbach Alpha for the adolescent (α = 0.864), parent (α = 0.842), and clinician (α = 0.722) versions of the scale. Test–retest reliability, inter-rater reliability, and content validity were good for all three versions of the STOP-SRiFS. The sub-scales generated using Exploratory Factor Analysis (EFA) were the (1) anxiety and depression risk, (2) substance misuse risk, (3) interpersonal risk, (4) chronic risk, and (5) risk due to life events. For the STOP-SRiFS, statistically significant correlations were found between the Columbia-Suicide Severity Rating Scale (C-SSRS) total score and the adolescent, parent, and clinical versions of the STOP-SRiFS sub-scale scores. The STOP-SRiFS showed good psychometric properties. This study demonstrated a good construct validity for the STOP-SReFS—the Cronbach Alpha for the three versions were good (adolescent: α = 0.775; parent: α = 0.808; α = clinician: 0.808). EFA for the adolescent version of the STOP-SReFS, which consists of 9 resilience factors domains, generated two factors (1) interpersonal resilience and (2) cognitive resilience. The STOP-SReFS Cognitive Resilience sub-scale for the adolescent was negatively correlated (r = − 0.275) with the C-SSRS total score, showing that there was lower suicidality in those with greater Cognitive Resilience. The STOP-SReFS Interpersonal resilience sub-scale correlations were all negative, but none of them were significantly different to the C-SSRS total scores for either the adolescent, parent, or clinician versions of the scales. This is not surprising, because the items in this sub-scale capture a much larger time-scale, compared to the C-SSRS rating period. The STOP-SReFS showed good psychometric properties. The STOP-SRiFS and STOP-SReFS are instruments that can be used in future studies about suicidality in children and adolescents. [ABSTRACT FROM AUTHOR]
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- 2020
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35. Degradation of interpenetrating polymer networks based on PE and polymethacrylates by electron beam irradiation
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Hu, J., Schulze, U., and Pionteck, J.
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- 1999
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36. Separation of glass transition and melting in polyethylene/poly(butyl-methacrylate- co-methyl-methacrylate) interpenetrating polymer networks in TMDSC and DSC curves
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Pompe, G., Schulze, U., Hu, J., Pionteck, J., and Höhne, G.W.H.
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- 1999
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37. Protocol for a cohort study of adolescent mental health service users with a nested cluster randomised controlled trial to assess the clinical and cost-effectiveness of managed transition in improving transitions from child to adult mental health services (the MILESTONE study)
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Singh, SP (Swaran Preet), Tuomainen, H, de Girolamo, G, Maras, Athanasios, Santosh, P, McNicholas, F, Schulze, U, Purper-Ouakil, D, Tremmery, S, Franic, T, Madan, J, Paul, M, Verhulst, Frank, Dieleman, Gwen, Warwick, J, Wolke, D, Street, C, Daffern, C, Tah, P, Griffin, J, Canaway, A, Signorini, G, Gerritsen, Suzanne, Adams, L, O'Hara, L, Aslan, Russet, F, Davidovic, N, Tuffrey, A, Wilson, A, Gatherer, C, Walker, L, Singh, SP (Swaran Preet), Tuomainen, H, de Girolamo, G, Maras, Athanasios, Santosh, P, McNicholas, F, Schulze, U, Purper-Ouakil, D, Tremmery, S, Franic, T, Madan, J, Paul, M, Verhulst, Frank, Dieleman, Gwen, Warwick, J, Wolke, D, Street, C, Daffern, C, Tah, P, Griffin, J, Canaway, A, Signorini, G, Gerritsen, Suzanne, Adams, L, O'Hara, L, Aslan, Russet, F, Davidovic, N, Tuffrey, A, Wilson, A, Gatherer, C, and Walker, L
- Published
- 2017
38. Occlusion in the Flow of New Drugs for Cardiovascular Disease
- Author
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Ringel, MS, primary, Shah, NA, additional, Baedeker, M, additional, Lim, CT, additional, Lamichhane, A, additional, and Schulze, U, additional
- Published
- 2017
- Full Text
- View/download PDF
39. ASpeKT – Schnittstellenkoordination bei psychisch erkrankten Kindern und Teenagern
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Williams, B., primary, Bülbül, A., primary, Fegert, J. M., primary, Boege, I., primary, and Schulze, U. M. E., additional
- Published
- 2017
- Full Text
- View/download PDF
40. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents
- Author
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Flamarique, I., Santosh, P., Zuddas, A., Arango, C., Purper-Ouakil, D., Hoekstra, P.J., Coghill, D., Schulze, U., Dittmann, R.W., Buitelaar, J.K., Lievesley, K., Frongia, R., Llorente, C., Mendez, I., Sala, R., Fiori, F., Castro-Fornieles, J., Flamarique, I., Santosh, P., Zuddas, A., Arango, C., Purper-Ouakil, D., Hoekstra, P.J., Coghill, D., Schulze, U., Dittmann, R.W., Buitelaar, J.K., Lievesley, K., Frongia, R., Llorente, C., Mendez, I., Sala, R., Fiori, F., and Castro-Fornieles, J.
- Abstract
Contains fulltext : 167718.pdf (publisher's version ) (Open Access), BACKGROUND: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. METHODS: As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) for children and adolescents and for proxy reports by parents and clinicians in order to assess suicidality. Based on a literature review, expert panels and focus groups of patients, we developed the items of the STOP Suicidality Assessment Scale (STOP-SAS) in Spanish and English, translated it into four more languages, and optimized it for web-based presentation using the HealthTrackerTM platform. Of the total 19 questions developed for the STOP-SAS, four questions that assess low-level suicidality were identified as screening questions (three of them for use with children, and all four for use with adolescents, parents and clinicians). A total of 395 adolescents, 110 children, 637 parents and 716 clinicians completed the questionnaire using the HealthTrackerTM, allowing us to evaluate the internal consistency and convergent validity of the STOP-SAS with the clinician-rated Columbia Suicide Severity Rating Scale (C-SSRS). Validity was also assessed with the receiver operating characteristic (ROC) area of the STOP-SAS with the C-SSRS. RESULTS: The STOP-SAS comprises 19 items in its adolescent, parent, and clinician versions, and 14 items in its children's version. Good internal consistency was found for adolescents (Cronbach's alpha: 0.965), children (Cronbach's alpha: 0.922), parents (Cronbach's alpha: 0.951) and clinicians (Cronbach's alpha: 0.955) versions. A strong correlation was found between the STOP-SAS and the C-SSRS for adolescents (r:0.670), parents (r:0.548), clinicians (r:0.863) and children (r:0.654). The ROC area was good for clinicians' (0.917), adolescents' (0.834) and parents' (0.756) versions but only fair (0.683) for children's version. CONCLUSIONS: The
- Published
- 2016
41. Development and psychometric properties of the Suicidality: Treatment Occurring in Paediatrics (STOP) Suicidality Assessment Scale (STOP-SAS) in children and adolescents
- Author
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Flamarique, I, Santosh, P, Zuddas, A, Arango, C, Purper-Ouakil, D, Hoekstra, PJ, Coghill, D, Schulze, U, Dittmann, RW, Buitelaar, JK, Lievesley, K, Frongia, R, Llorente, C, Mendez, I, Sala, R, Fiori, F, Castro-Fornieles, J, Flamarique, I, Santosh, P, Zuddas, A, Arango, C, Purper-Ouakil, D, Hoekstra, PJ, Coghill, D, Schulze, U, Dittmann, RW, Buitelaar, JK, Lievesley, K, Frongia, R, Llorente, C, Mendez, I, Sala, R, Fiori, F, and Castro-Fornieles, J
- Abstract
BACKGROUND: To create a self-reported, internet-based questionnaire for the assessment of suicide risk in children and adolescents. METHODS: As part of the EU project 'Suicidality: Treatment Occurring in Paediatrics' (STOP project), we developed web-based Patient Reported Outcome Measures (PROMs) for children and adolescents and for proxy reports by parents and clinicians in order to assess suicidality. Based on a literature review, expert panels and focus groups of patients, we developed the items of the STOP Suicidality Assessment Scale (STOP-SAS) in Spanish and English, translated it into four more languages, and optimized it for web-based presentation using the HealthTrackerTM platform. Of the total 19 questions developed for the STOP-SAS, four questions that assess low-level suicidality were identified as screening questions (three of them for use with children, and all four for use with adolescents, parents and clinicians). A total of 395 adolescents, 110 children, 637 parents and 716 clinicians completed the questionnaire using the HealthTrackerTM, allowing us to evaluate the internal consistency and convergent validity of the STOP-SAS with the clinician-rated Columbia Suicide Severity Rating Scale (C-SSRS). Validity was also assessed with the receiver operating characteristic (ROC) area of the STOP-SAS with the C-SSRS. RESULTS: The STOP-SAS comprises 19 items in its adolescent, parent, and clinician versions, and 14 items in its children's version. Good internal consistency was found for adolescents (Cronbach's alpha: 0.965), children (Cronbach's alpha: 0.922), parents (Cronbach's alpha: 0.951) and clinicians (Cronbach's alpha: 0.955) versions. A strong correlation was found between the STOP-SAS and the C-SSRS for adolescents (r:0.670), parents (r:0.548), clinicians (r:0.863) and children (r:0.654). The ROC area was good for clinicians' (0.917), adolescents' (0.834) and parents' (0.756) versions but only fair (0.683) for children's version. CONCLUSIONS: The
- Published
- 2016
42. MATE1 regulates cellular uptake and sensitivity to imatinib in CML patients
- Author
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Harrach, S, primary, Schmidt-Lauber, C, additional, Pap, T, additional, Pavenstädt, H, additional, Schlatter, E, additional, Schmidt, E, additional, Berdel, W E, additional, Schulze, U, additional, Edemir, B, additional, Jeromin, S, additional, Haferlach, T, additional, Ciarimboli, G, additional, and Bertrand, J, additional
- Published
- 2016
- Full Text
- View/download PDF
43. Model calculations on the magnetization processes in moderate fields of CuMn-like alloys below the freezing temperature
- Author
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Schwink, Ch., Emmerich, K., and Schulze, U.
- Published
- 1978
- Full Text
- View/download PDF
44. Programmed death-1 ligands are expressed in the majority of advanced serous epithelial ovarian cancer
- Author
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Vermeij, R., Geertruida H. de Bock, Ten Hoor, K. A., Schulze, U., Harry Hollema, Toos Daemen, Hans Nijman, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Targeted Gynaecologic Oncology (TARGON), and Translational Immunology Groningen (TRIGR)
- Subjects
endocrine system diseases ,receptor ,ovary cancer ,memory T lymphocyte ,CD8 antigen ,tumor associated leukocyte ,ligand ,society ,regulatory T lymphocyte ,confidence interval ,death ,oncology ,immunohistochemistry ,ovary carcinoma ,tissues ,human ,patient ,prognosis ,neoplasm ,risk - Abstract
Introduction: Immunotherapeutic strategies have been developed and tested in ovarian carcinoma patients, but no single approach has proven clinical effective yet. These disappointing clinical results were explained by immune escape mechanisms such as the immune suppressive pathway of the programmed death-1 (PD-1) receptor, and its ligands PD-L1 and PD-L2. Objective: We determined the prognostic importance of immune inhibitory ligands PD-L1 and PD-L2, in a well-defined homogeneous subgroup of epithelial ovarian cancer (EOC). Methods: PD-L1/L2 expression was evaluated in primary advanced serous EOC tissue of 127 patients by immunohistochemistry using tissue microarrays (TMAs). PD-L1/L2 expression, was correlated with the number of tumor infiltrating lymphocytes (TIL) and TIL-subsets data, i.e. CD8+ cytotoxic- (CTL), FoxP3+ regulatory- (Tregs) and CD45R0+ memory T-lymphocytes. Results: PD-L1 and PD-L2 expression was observed in 65 (61.9%) and 77 (73.3%) of 127 tumor samples, respectively. Prognosis was not influenced by the expression of PD-L1 or PD-L2 in advanced serous EOC patients. Moreover, PD-L1 expression did not correlate with the number of one of the TIL subsets. PD-L2 expression correlated negatively with the number of memory T-cells [odds ratio (OR), 0.2; 95% confidence interval (95% CI), 0.1-0.5; P = 0.001] and positively with the number of CTL (OR, 3.2; 95% CI, 1.1-9.5, P = 0.037). Conclusion: Despite high expression rates of PD-L1/L2, PD-Ls have no prognostic impact in advanced serous EOC. Blockade of the PD-1/PD-Ls pathway may not provide a beneficial effect for immunotherapeutic treatment of advanced serous EOC.
- Published
- 2011
45. The gender wage gap among PhDs in the UK
- Author
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Schulze, U., primary
- Published
- 2015
- Full Text
- View/download PDF
46. Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges
- Author
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Glennon, J.C., Purper-Ouakil, D., Bakker, M, Zuddas, A., Hoekstra, P.J., Schulze, U., Castro-Fornieles, J., Santosh, P.J., Arango, C., Kolch, M., Coghill, D., Flamarique, I., Penzol, M.J., Wan, M., Murray, M., Wong, I.C., Danckaerts, M., Bonnot, O., Falissard, B., Masi, G., Fegert, J.M., Vicari, S., Carucci, S., Dittmann, R.W., Buitelaar, J.K., et al., Glennon, J.C., Purper-Ouakil, D., Bakker, M, Zuddas, A., Hoekstra, P.J., Schulze, U., Castro-Fornieles, J., Santosh, P.J., Arango, C., Kolch, M., Coghill, D., Flamarique, I., Penzol, M.J., Wan, M., Murray, M., Wong, I.C., Danckaerts, M., Bonnot, O., Falissard, B., Masi, G., Fegert, J.M., Vicari, S., Carucci, S., Dittmann, R.W., Buitelaar, J.K., and et al.
- Abstract
Item does not contain fulltext, In children and adolescents with conduct disorder (CD), pharmacotherapy is considered when non-pharmacological interventions do not improve symptoms and functional impairment. Risperidone, a second-generation antipsychotic is increasingly prescribed off-label in this indication, but its efficacy and tolerability is poorly studied in CD, especially in young people with normal intelligence. The Paediatric European Risperidone Studies (PERS) include a series of trials to assess short-term efficacy, tolerability and maintenance effects of risperidone in children and adolescents with CD and normal intelligence as well as long-term tolerability in a 2-year pharmacovigilance. In addition to its core studies, secondary PERS analyses will examine moderators of drug effects. As PERS is a large-scale academic project involving a collaborative network of expert centres from different countries, it is expected that results will lead to strengthen the evidence base for the use of risperidone in CD and improve standards of care. Challenging issues faced by the PERS consortium are described to facilitate future developments in paediatric neuropsychopharmacology.
- Published
- 2014
47. Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges
- Author
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Glennon, J, Purper-Ouakil, D, Bakker, M, Zuddas, A, Hoekstra, P, Schulze, U, Castro-Fornieles, J, Santosh, PJ, Arango, C, Koelch, M, Coghill, D, Flamarique, I, Penzol, MJ, Wan, M, Murray, M, Wong, ICK, Danckaerts, M, Bonnot, O, Falissard, B, Masi, G, Fegart, JM, Vicari, S, Carucci, S, Dittmann, RW, Buitelaar, JK, Glennon, J, Purper-Ouakil, D, Bakker, M, Zuddas, A, Hoekstra, P, Schulze, U, Castro-Fornieles, J, Santosh, PJ, Arango, C, Koelch, M, Coghill, D, Flamarique, I, Penzol, MJ, Wan, M, Murray, M, Wong, ICK, Danckaerts, M, Bonnot, O, Falissard, B, Masi, G, Fegart, JM, Vicari, S, Carucci, S, Dittmann, RW, and Buitelaar, JK
- Abstract
In children and adolescents with conduct disorder (CD), pharmacotherapy is considered when non-pharmacological interventions do not improve symptoms and functional impairment. Risperidone, a second-generation antipsychotic is increasingly prescribed off-label in this indication, but its efficacy and tolerability is poorly studied in CD, especially in young people with normal intelligence. The Paediatric European Risperidone Studies (PERS) include a series of trials to assess short-term efficacy, tolerability and maintenance effects of risperidone in children and adolescents with CD and normal intelligence as well as long-term tolerability in a 2-year pharmacovigilance. In addition to its core studies, secondary PERS analyses will examine moderators of drug effects. As PERS is a large-scale academic project involving a collaborative network of expert centres from different countries, it is expected that results will lead to strengthen the evidence base for the use of risperidone in CD and improve standards of care. Challenging issues faced by the PERS consortium are described to facilitate future developments in paediatric neuropsychopharmacology.
- Published
- 2014
48. Paediatric European Risperidone Studies (PERS): context, rationale, objectives, strategy, and challenges
- Author
-
Glennon, J., Purper-Ouakil, D., Bakker, M., Zuddas, A., Hoekstra, P., Schulze, U., Castro-Fornieles, J., Santosh, P. J., Arango, C., Kolch, M., Coghill, D., Flamarique, I., Penzol, M. J., Wan, M., Murray, M., Wong, I. C. K., Danckaerts, M., Bonnot, O., Falissard, B., Masi, G., Fegert, J. M., Vicari, S., Carucci, S., Dittmann, R. W., Buitelaar, J. K., Vicari S. (ORCID:0000-0002-5395-2262), Glennon, J., Purper-Ouakil, D., Bakker, M., Zuddas, A., Hoekstra, P., Schulze, U., Castro-Fornieles, J., Santosh, P. J., Arango, C., Kolch, M., Coghill, D., Flamarique, I., Penzol, M. J., Wan, M., Murray, M., Wong, I. C. K., Danckaerts, M., Bonnot, O., Falissard, B., Masi, G., Fegert, J. M., Vicari, S., Carucci, S., Dittmann, R. W., Buitelaar, J. K., and Vicari S. (ORCID:0000-0002-5395-2262)
- Abstract
In children and adolescents with conduct disorder (CD), pharmacotherapy is considered when non-pharmacological interventions do not improve symptoms and functional impairment. Risperidone, a second-generation antipsychotic is increasingly prescribed off-label in this indication, but its efficacy and tolerability is poorly studied in CD, especially in young people with normal intelligence. The Paediatric European Risperidone Studies (PERS) include a series of trials to assess short-term efficacy, tolerability and maintenance effects of risperidone in children and adolescents with CD and normal intelligence as well as long-term tolerability in a 2-year pharmacovigilance. In addition to its core studies, secondary PERS analyses will examine moderators of drug effects. As PERS is a large-scale academic project involving a collaborative network of expert centres from different countries, it is expected that results will lead to strengthen the evidence base for the use of risperidone in CD and improve standards of care. Challenging issues faced by the PERS consortium are described to facilitate future developments in paediatric neuropsychopharmacology.
- Published
- 2014
49. The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes
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Wennmann, D O, primary, Vollenbröker, B, additional, Eckart, A K, additional, Bonse, J, additional, Erdmann, F, additional, Wolters, D A, additional, Schenk, L K, additional, Schulze, U, additional, Kremerskothen, J, additional, Weide, T, additional, and Pavenstädt, H, additional
- Published
- 2014
- Full Text
- View/download PDF
50. 2H nmr investigations of hydration forces between lipid bilayers
- Author
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Gawrisch, K., primary, Arnold, K, additional, Dietze, K., additional, and Schulze, U., additional
- Published
- 1986
- Full Text
- View/download PDF
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