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4. Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions

Author

Lindström, Sara, Wang, Lu, Feng, Helian, Majumdar, Arunabha, Huo, Sijia, Macdonald, James, Harrison, Tabitha, Turman, Constance, Chen, Hongjie, Mancuso, Nicholas, Bammler, Theo, Consortium, Breast Cancer Association, Gallinger, Steve, Gruber, Stephen B, Gunter, Marc J, Le Marchand, Loic, Moreno, Victor, Offit, Kenneth, Study, Genetics And Epidemiology Of Colorectal Cancer Consortium Colorectal Transdisciplinary Study Colon Cancer Family Registry, De Vivo, Immaculata, O’Mara, Tracy A, Spurdle, Amanda B, Tomlinson, Ian, Consortium, Endometrial Cancer Association, Fitzgerald, Rebecca, Gharahkhani, Puya, Gockel, Ines, Jankowski, Janusz, Macgregor, Stuart, Schumacher, Johannes, Barnholtz-Sloan, Jill, Bondy, Melissa L, Houlston, Richard S, Jenkins, Robert B, Melin, Beatrice, Wrensch, Margaret, Brennan, Paul, Christiani, David C, Johansson, Mattias, Mckay, James, Aldrich, Melinda C, Amos, Christopher I, Landi, Maria Teresa, Tardon, Adonina, Consortium, International Lung Cancer, Bishop, D Timothy, Demenais, Florence, Goldstein, Alisa M, Iles, Mark M, Kanetsky, Peter A, Law, Matthew H, Consortium, Ovarian Cancer Association, Amundadottir, Laufey T, Stolzenberg-Solomon, Rachael, Wolpin, Brian M, Consortium, Pancreatic Cancer Cohort, Klein, Alison, Petersen, Gloria, Risch, Harvey, Consortium, The PRACTICAL Consortium Pancreatic Cancer Case-Control, Chanock, Stephen J, Purdue, Mark P, Scelo, Ghislaine, Pharoah, Paul, Kar, Siddhartha, Hung, Rayjean J, Pasaniuc, Bogdan, and Kraft, Peter

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Human Genome, Genetics, Digestive Diseases, Prevention, Clinical Research, Urologic Diseases, Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Male, Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Neoplasms, Risk Factors, Transcriptome, Polymorphism, Single Nucleotide, Breast Cancer Association Consortium, Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And Epidemiology Of Colorectal Cancer Consortium, Endometrial Cancer Association Consortium, International Lung Cancer Consortium, Ovarian Cancer Association Consortium, Pancreatic Cancer Cohort Consortium, Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThe shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.MethodsWe collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed the extent of variant-specific pleiotropy among cancers at known and newly identified cancer susceptibility loci.ResultsWe observed widespread but modest genome-wide genetic correlations across cancers. In cross-cancer GWAS and transcriptome-wide association studies, we identified 15 novel cancer susceptibility loci. Additionally, we identified multiple variants at 77 distinct loci with strong evidence of being associated with at least 2 cancer types by testing for pleiotropy at known cancer susceptibility loci.ConclusionsOverall, these results suggest that some genetic risk variants are shared among cancers, though much of cancer heritability is cancer-specific and thus tissue-specific. The increase in statistical power associated with larger sample sizes in cross-disease analysis allows for the identification of novel susceptibility regions. Future studies incorporating data on multiple cancer types are likely to identify additional regions associated with the risk of multiple cancer types.

Published
2023

6. PRECYCLE: multicenter, randomized phase IV intergroup trial to evaluate the impact of eHealth-based patient-reported outcome (PRO) assessment on quality of life in patients with hormone receptor positive, HER2 negative locally advanced or metastatic breast cancer treated with palbociclib and an aromatase inhibitor or palbociclib and fulvestrant

Author

Degenhardt, Tom, Fasching, Peter A., Lüftner, Diana, Müller, Volkmar, Thomssen, Christoph, Schem, Christian, Witzel, Isabell, Decker, Thomas, Tesch, Hans, Kümmel, Sherko, Uleer, Christoph, Wuerstlein, Rachel, Hoffmann, Oliver, Warm, Mathias, Marschner, Norbert, Schinköthe, Timo, Kates, Ronald E., Schumacher, Johannes, Otremba, Burkhard, Zaiss, Matthias, Harbeck, Nadia, and Schmidt, Marcus

Published
2023
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7. Above-ground biomass change estimation using national forest inventory data with Sentinel-2 and Landsat 8

Author

Puliti, Stefano, Breidenbach, Johannes, Schumacher, Johannes, Hauglin, Marius, Klingenberg, Torgeir Ferdinand, and Astrup, Rasmus

Subjects
Statistics - Applications, Quantitative Biology - Quantitative Methods
Abstract

This study aimed at estimating total forest above-ground net change (Delta AGB, Mt) over five years (2014-2019) based on model-assisted estimation utilizing freely available satellite imagery. The study was conducted for a boreal forest area (approx. 1.4 Mill hectares) in Norway where bi-temporal national forest inventory (NFI), Sentinel-2, and Landsat data were available. Biomass change was modelled based on a direct approach. The precision of estimates using only the NFI data in a basic expansion estimator were compared to four different alternative model-assisted estimates using 1) Sentinel-2 or Landsat data, and 2) using bi- or uni-temporal remotely sensed data. We found that the use of remotely sensed data improved the precision of the purely field-based estimates by a factor of up to three. The most precise estimates were found for the model-assisted estimation using bi-temporal Sentinel-2 (standard error; SE= 1.7 Mt). However, the decrease in precision when using Landsat data was small (SE= 1.92 Mt). In addition, we found that Delta AGB could be precisely estimated also when remotely sensed data were available only at the end of the monitoring period. We conclude that satellite optical data can considerably improve Delta AGB estimates, even in those cases where repeated and coincident NFI data are available. The free availability, global coverage, frequent update, and long-term time horizon make data from programs such as Sentinel-2 and Landsat a valuable data source for a consistent and durable monitoring of forest carbon dynamics.

Published
2020

8. Mapping forest age using National Forest Inventory, airborne laser scanning, and Sentinel-2 data

Author

Schumacher, Johannes, Hauglin, Marius, Astrup, Rasmus, and Breidenbach, Johannes

Subjects
Statistics - Applications
Abstract

The age of forest stands is critical information for many aspects of forest management and conservation but area-wide information about forest stand age often does not exist. In this study, we developed regression models for large-scale area-wide prediction of age in Norwegian forests. For model development we used more than 4800 plots of the Norwegian National Forest Inventory (NFI) distributed over Norway between 58{\deg} and 65{\deg} northern latitude in a 181,773 km2 study area. Predictor variables were based on airborne laser scanning (ALS), Sentinel-2, and existing public map data. We performed model validation on an independent data set consisting of 63 spruce stands with known age. The best modelling strategy was to fit independent linear regression models to each observed site index (SI) level and using a SI prediction map in the application of the models. The most important predictor variable was an upper percentile of the ALS heights, and root-mean-squared-errors (RMSE) ranged between 3 and 31 years (6% to 26%) for SI-specific models, and 21 years (25%) on average. Mean deviance (MD) ranged between -1 and 3 years. The models improved with increasing SI and the RMSE were largest for low SI stands older than 100 years. Using a mapped SI, which is required for practical applications, RMSE and MD on plot-level ranged from 19 to 56 years (29% to 53%), and 5 to 37 years (5% to 31%), respectively. For the validation stands, the RMSE and MD were 12 (22%) and 2 years (3%). Tree height estimated from airborne laser scanning and predicted site index were the most important variables in the models describing age. Overall, we obtained good results, especially for stands with high SI, that could be considered for practical applications but see considerable potential for improvements, if better SI maps were available.

Published
2020

9. National mapping and estimation of forest area by dominant tree species using Sentinel-2 data

Author

Breidenbach, Johannes, Waser, Lars T., Debella-Gilo, Misganu, Schumacher, Johannes, Rahlf, Johannes, Hauglin, Marius, Puliti, Stefano, and Astrup, Rasmus

Subjects
Statistics - Applications
Abstract

Nation-wide Sentinel-2 mosaics were used with National Forest Inventory (NFI) data for modelling and subsequent mapping of spruce, pine and deciduous forest in Norway in 16 m $\times$ 16 m resolution. The accuracies of the best model ranged between 74% for spruce and 87% for deciduous forest. An overall accuracy of 90% was found on stand level using independent data from more than 42.000 stands. Errors mostly resulting from a forest mask reduced the model accuracies by approximately 10%. Nonetheless, efficiencies of national forest area estimates increased by 20% to 50% for model-assisted (MA) estimates and up to 90% for poststratification (PS). Greater minimum number of observations, however, constrained the use of PS. For estimates of sub-populations (municipalities), efficiencies improved by up to a factor of 8. However, even for municipalities with a decent number of NFI plots, direct NFI estimates were sometimes more precise than MA estimates. PS estimates were always more precise than direct and MA estimates but were applicable in fewer municipalities. The tree species prediction map is freely available as part of the Norwegian forest resource map and is used, among others, to improve maps of other variables of interest such as timber volume and biomass., Comment: minor changes compared to submitted article; 34 pages, 13 figures, 11 tables

Published
2020
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10. Favorable impact of therapy management by an interactive eHealth system on severe adverse events in patients with hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer treated by palbociclib and endocrine therapy

Author

Harbeck, Nadia, Kates, Ronald, Schinköthe, Timo, Schumacher, Johannes, Wuerstlein, Rachel, Degenhardt, Tom, Lüftner, Diana, Räth, Philip, Hoffmann, Oliver, Lorenz, Ralf, Decker, Thomas, Reinisch, Mattea, Göhler, Thomas, Staib, Peter, Gluz, Oleg, Fasching, Peter A, and Schmidt, Marcus

Published
2023
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12. Abstract 18244: A Multi-Ancestry GWAS of Calcific Aortic Stenosis Among 2.7 Million Individuals

Author

Small, Aeron M, Dufresne, Line, Farber-Eger, Eric, Abner, Erik, Corey, Kristin, Stefánsson, Kári, Nadauld, Lincoln, Bundgaard, Henning, Lee, Jiwoo, Schumacher, Johannes, Trenkwalder, Teresa, Soderberg, Stefan, Ganna, Andrea, Rader, Daniel J, Moksnes, Marta Riise, Lin, Meng, Laporte, Fabien, Larsson, Susanna, Smith, Gustav, Do, Ron, Ito, Kaoru, Holm, Hilma, Sun, Yan, Kim, Kelly, WILSON, PETER, Odonnell, Christopher J, Peloso, Gina, Engert, Jamie C, Thanassoulis, George, and Natarajan, Pradeep

Published
2023
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15. A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

Author

Mingardo, Enrico, Beaman, Glenda, Grote, Philip, Nordenskjöld, Agneta, Newman, William, Woolf, Adrian S., Eckstein, Markus, Hilger, Alina C., Dworschak, Gabriel C., Rösch, Wolfgang, Ebert, Anne-Karolin, Stein, Raimund, Brusco, Alfredo, Di Grazia, Massimo, Tamer, Ali, Torres, Federico M., Hernandez, Jose L., Erben, Philipp, Maj, Carlo, Olmos, Jose M., Riancho, Jose A., Valero, Carmen, Hostettler, Isabel C., Houlden, Henry, Werring, David J., Schumacher, Johannes, Gehlen, Jan, Giel, Ann-Sophie, Buerfent, Benedikt C., Arkani, Samara, Åkesson, Elisabeth, Rotstein, Emilia, Ludwig, Michael, Holmdahl, Gundela, Giorgio, Elisa, Berettini, Alfredo, Keene, David, Cervellione, Raimondo M., Younsi, Nina, Ortlieb, Melissa, Oswald, Josef, Haid, Bernhard, Promm, Martin, Neissner, Claudia, Hirsch, Karin, Stehr, Maximilian, Schäfer, Frank-Mattias, Schmiedeke, Eberhard, Boemers, Thomas M., van Rooij, Iris A. L. M., Feitz, Wouter F. J., Marcelis, Carlo L. M., Lacher, Martin, Nelson, Jana, Ure, Benno, Fortmann, Caroline, Gale, Daniel P., Chan, Melanie M. Y., Ludwig, Kerstin U., Nöthen, Markus M., Heilmann, Stefanie, Zwink, Nadine, Jenetzky, Ekkehart, Odermatt, Benjamin, Knapp, Michael, and Reutter, Heiko

Published
2022
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18. A Multi-Objective Interpretation of Optimal Transport

Author

Schumacher, Johannes M.

Subjects
Mathematics - Optimization and Control
Abstract

This paper connects discrete optimal transport to a certain class of multi-objective optimization problems. In both settings, the decision variables can be organized into a matrix. In the multi-objective problem, the notion of Pareto efficiency is defined in terms of the objectives together with non-negativity constraints and with equality constraints that are specified in terms of column sums. A second set of equality constraints, defined in terms of row sums, is used to single out particular points in the Pareto efficient set which are referred to as "balanced solutions". Examples from several fields are shown in which this solution concept appears naturally. Balanced solutions are shown to be in one-to-one correspondence with solutions of optimal transport problems. As an example of the use of alternative interpretations, the computation of solutions via regularization is discussed.

Published
2017

19. S-Band Patch Antenna System for CubeSat Applications

Author

Kaur, Ravneet, Mayank, Tandon, Tushar, Schumacher, Johannes, Sundaramoorthy, Guhan, Sahoo, Udit Kumar, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, and Arai, Kohei, editor

Published
2021
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21. Impact of Electronic Patient-Reported Outcomes on Unplanned Consultations and Hospitalizations in Patients With Cancer Undergoing Systemic Therapy: Results of a Patient-Reported Outcome Study Compared With Matched Retrospective Data

Author

Trojan, Andreas, primary, Kühne, Christian, additional, Kiessling, Michael, additional, Schumacher, Johannes, additional, Dröse, Stefan, additional, Singer, Christian, additional, Jackisch, Christian, additional, Thomssen, Christoph, additional, and Kullak-Ublick, Gerd A, additional

Published
2024
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22. LiDAR Applications to Forest-Water Interactions

Author

Schumacher, Johannes, Christiansen, Jesper Riis, Canadell, Josep G., Series Editor, Díaz, Sandra, Series Editor, Heldmaier, Gerhard, Series Editor, Jackson, Robert B., Series Editor, Levia, Delphis F., Series Editor, Schulze, Ernst-Detlef, Series Editor, Sommer, Ulrich, Series Editor, Wardle, David A., Series Editor, Carlyle-Moses, Darryl E., editor, Iida, Shin'ichi, editor, Michalzik, Beate, editor, Nanko, Kazuki, editor, and Tischer, Alexander, editor

Published
2020
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24. Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

Author

The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anastasi, Gioacchino Alex, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A., Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G., Blanco, Alberto, Blanco, Miguel, Blazek, Jiri, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bretz, Thomas, Bridgeman, Ariel, Brogueira, Pedro, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S., Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G., Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J., Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R., de Almeida, Rogerio M., de Jong, Sijbrand J., De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Anjos, Rita dos, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O., Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P., Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fratu, Octavian, Freire, Martín Miguel, Fujii, Toshihiro, García, Beatriz, Garcia-Gamez, Diego, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F. Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D., Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A., Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E., Hill, Gary C., Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A., Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Keilhauer, Bianca, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Kuempel, Daniel, Mezek, Gasper Kukec, Kunka, Norbert, Awad, Alaa Metwaly Kuotb, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lucero, Agustin, Malacari, Max, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A., Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A., Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Nguyen, Phong H., Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Núñez, Luis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Reinert, Darius, Revenu, Benoît, Ridky, Jan, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J., Saftoiu, Alexandra, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Gomez, Jose Sanabria, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sarmiento-Cano, Christian, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G., Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C., Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sonntag, Sebastian, Sorokin, J., Squartini, Ruben, Srivastava, Yogendra N., Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Durán, Mauricio Suarez, Suomijärvi, Tiina, Supanitsky, A. Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Timmermans, Charles, Peixoto, Carlos J. Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Trini, Marta, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F. Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M. van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R., Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Welling, Christoph, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory., Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary files

Published
2016
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25. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

Author

Forstner, Andreas J., Awasthi, Swapnil, Wolf, Christiane, Maron, Eduard, Erhardt, Angelika, Czamara, Darina, Eriksson, Elias, Lavebratt, Catharina, Allgulander, Christer, Friedrich, Nina, Becker, Jessica, Hecker, Julian, Rambau, Stefanie, Conrad, Rupert, Geiser, Franziska, McMahon, Francis J., Moebus, Susanne, Hess, Timo, Buerfent, Benedikt C., Hoffmann, Per, Herms, Stefan, Heilmann-Heimbach, Stefanie, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars, Weber, Heike, Alpers, Georg W., Arolt, Volker, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Hamm, Alfons, Kircher, Tilo, Pané-Farré, Christiane A., Pauli, Paul, Rief, Winfried, Ströhle, Andreas, Plag, Jens, Lang, Thomas, Wittchen, Hans-Ulrich, Mattheisen, Manuel, Meier, Sandra, Metspalu, Andres, Domschke, Katharina, Reif, Andreas, Hovatta, Iiris, Lindefors, Nils, Andersson, Evelyn, Schalling, Martin, Mbarek, Hamdi, Milaneschi, Yuri, de Geus, Eco J. C., Boomsma, Dorret I., Penninx, Brenda W. J. H., Thorgeirsson, Thorgeir E., Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, Müller-Myhsok, Bertram, Hansen, Thomas Folkmann, Børglum, Anders D., Werge, Thomas, Mortensen, Preben Bo, Nordentoft, Merete, Hougaard, David M., Hultman, Christina M., Sullivan, Patrick F., Nöthen, Markus M., Woldbye, David P. D., Mors, Ole, Binder, Elisabeth B., Rück, Christian, Ripke, Stephan, Deckert, Jürgen, and Schumacher, Johannes

Published
2021
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26. Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia

Author

Gialluisi, Alessandro, Andlauer, Till F. M., Mirza-Schreiber, Nazanin, Moll, Kristina, Becker, Jessica, Hoffmann, Per, Ludwig, Kerstin U., Czamara, Darina, Pourcain, Beate St, Honbolygó, Ferenc, Tóth, Dénes, Csépe, Valéria, Huguet, Guillaume, Chaix, Yves, Iannuzzi, Stephanie, Demonet, Jean-Francois, Morris, Andrew P., Hulslander, Jacqueline, Willcutt, Erik G., DeFries, John C., Olson, Richard K., Smith, Shelley D., Pennington, Bruce F., Vaessen, Anniek, Maurer, Urs, Lyytinen, Heikki, Peyrard-Janvid, Myriam, Leppänen, Paavo H. T., Brandeis, Daniel, Bonte, Milene, Stein, John F., Talcott, Joel B., Fauchereau, Fabien, Wilcke, Arndt, Kirsten, Holger, Müller, Bent, Francks, Clyde, Bourgeron, Thomas, Monaco, Anthony P., Ramus, Franck, Landerl, Karin, Kere, Juha, Scerri, Thomas S., Paracchini, Silvia, Fisher, Simon E., Schumacher, Johannes, Nöthen, Markus M., Müller-Myhsok, Bertram, and Schulte-Körne, Gerd

Published
2021
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27. Comparison of the Real-World Reporting of Symptoms and Well-Being for the HER2-Directed Trastuzumab Biosimilar Ogivri With Registry Data for Herceptin in the Treatment of Breast Cancer: Prospective Observational Study (OGIPRO) of Electronic Patient-Reported Outcomes

Author

Trojan, Andreas; https://orcid.org/0000-0001-7257-9312, Roth, Sven; https://orcid.org/0009-0001-6063-7447, Atassi, Ziad; https://orcid.org/0009-0005-1677-1031, Kiessling, Michael; https://orcid.org/0000-0001-6784-4599, Zenhaeusern, Reinhard; https://orcid.org/0009-0000-1931-9239, Kadvany, Yannick; https://orcid.org/0009-0005-0404-6000, Schumacher, Johannes; https://orcid.org/0009-0002-4129-5880, Kullak-Ublick, Gerd A; https://orcid.org/0000-0002-0757-4408, Aapro, Matti; https://orcid.org/0000-0003-3570-8319, Eniu, Alexandru; https://orcid.org/0000-0001-6666-5599, Trojan, Andreas; https://orcid.org/0000-0001-7257-9312, Roth, Sven; https://orcid.org/0009-0001-6063-7447, Atassi, Ziad; https://orcid.org/0009-0005-1677-1031, Kiessling, Michael; https://orcid.org/0000-0001-6784-4599, Zenhaeusern, Reinhard; https://orcid.org/0009-0000-1931-9239, Kadvany, Yannick; https://orcid.org/0009-0005-0404-6000, Schumacher, Johannes; https://orcid.org/0009-0002-4129-5880, Kullak-Ublick, Gerd A; https://orcid.org/0000-0002-0757-4408, Aapro, Matti; https://orcid.org/0000-0003-3570-8319, and Eniu, Alexandru; https://orcid.org/0000-0001-6666-5599

Abstract

Background Trastuzumab has had a major impact on the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Anti-HER2 biosimilars such as Ogivri have demonstrated safety and clinical equivalence to trastuzumab (using Herceptin as the reference product) in clinical trials. To our knowledge, there has been no real-world report of the side effects and quality of life (QoL) in patients treated with biosimilars using electronic patient-reported outcomes (ePROs). Objective The primary objective of this prospective observational study (OGIPRO study) was to compare the ePRO data related to treatment side effects collected with the medidux app in patients with HER2-positive BC treated with the trastuzumab biosimilar Ogivri (prospective cohort) to those obtained from historical cohorts treated with Herceptin alone or combined with pertuzumab and/or chemotherapy (ClinicalTrials.gov NCT02004496 and NCT03578731). Methods Patients were treated with Ogivri alone or combined with pertuzumab and/or chemotherapy and hormone therapy in (neo)adjuvant and palliative settings. Patients used the medidux app to dynamically record symptoms (according to the Common Terminology Criteria for Adverse Events [CTCAE]), well-being (according to the Eastern Cooperative Oncology Group Performance Status scale), QoL (using the EQ-5D-5L questionnaire), cognitive capabilities, and vital parameters over 6 weeks. The primary endpoint was the mean CTCAE score. Key secondary endpoints included the mean well-being score. Data of this prospective cohort were compared with those of the historical cohorts (n=38 patients; median age 51, range 31-78 years). Results Overall, 53 female patients with a median age of 54 years (range 31-87 years) were enrolled in the OGIPRO study. The mean CTCAE score was analyzed in 50 patients with available data on symptoms, while the mean well-being score was evaluated in 52 patients with available data. The most common symptoms reported in both

Published
2024

28. Design study of an air-Cherenkov telescope for harsh environments with efficient air-shower detection at 100 TeV

Author

Auffenberg, Jan, Bretz, Thomas, Middendorf, Lukas, Niggemann, Tim, Rädel, Leif, Schaufel, Merlin, Schoenen, Sebastian, Schumacher, Johannes, and Wiebusch, Christopher

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Telescopes, designed with semi-conductor based photo sensors, have the potential to detect Cherenkov or fluorescence light emitted by cosmic-rays in the atmosphere. Such telescopes promise a high duty cycle and efficiency in remote harsh environments. Given the relatively low costs and robustness of these instruments, this technology could prove interesting especially if deployed in large numbers with existing and future extended cosmic-ray and gamma ray detectors, including the Pierre Auger observatory, HAWC, IceCube and CTA. They may have the potential to enhance the sensitivity of these instruments for the detection of high-energy gamma rays and cosmic-ray air showers. In addition, for neutrino telescopes such a technology could prove to be an efficient cosmic-ray veto on the surface. In this contribution the current motivation, design, and development of a prototype SiPM based air Cherenkov telescope is described. The results of initial sensitivity studies, and the readiness of the system for first tests, including those proposed for the South Pole are shown.

Published
2015

29. Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anastasi, Gioacchino Alex, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A., Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G., Blanco, Alberto, Blanco, Miguel, Blazek, Jiri, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bretz, Thomas, Bridgeman, Ariel, Brogueira, Pedro, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S., Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G., Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J., Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R., de Almeida, Rogerio M., de Jong, Sijbrand J., De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Anjos, Rita dos, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O., Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P., Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fratu, Octavian, Freire, Martín Miguel, Fujii, Toshihiro, García, Beatriz, Garcia-Gamez, Diego, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F. Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D., Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A., Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E., Hill, Gary C., Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A., Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Keilhauer, Bianca, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Kuempel, Daniel, Mezek, Gasper Kukec, Kunka, Norbert, Awad, Alaa Metwaly Kuotb, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lucero, Agustin, Malacari, Max, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A., Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A., Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Nguyen, Phong H., Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Núñez, Luis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Reinert, Darius, Revenu, Benoît, Ridky, Jan, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J., Saftoiu, Alexandra, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Gomez, Jose Sanabria, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sarmiento-Cano, Christian, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G., Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C., Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sonntag, Sebastian, Sorokin, J., Squartini, Ruben, Srivastava, Yogendra N., Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Durán, Mauricio Suarez, Suomijärvi, Tiina, Supanitsky, A. Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Tibolla, Omar, Timmermans, Charles, Peixoto, Carlos J. Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Trini, Marta, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F. Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M. van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R., Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Welling, Christoph, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal., Comment: Replaced with published version. Added journal reference and DOI

Published
2015
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30. An improved limit to the diffuse flux of ultra-high energy neutrinos from the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Aranda, Victor Manuel, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Ave, Maximo, Avenier, Michel, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Barber, Kerri B, Bäuml, Julia, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A, Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G, Blanco, Alberto, Blanco, Miguel, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bridgeman, Ariel, Brogueira, Pedro, Brown, William C, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S, Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G, Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J, Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R, de Almeida, Rogerio M, de Jong, Sijbrand J, De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dembinski, Hans, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O, Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P, Fernandes, Mateus, Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fox, Brendan, Fratu, Octavian, Freire, Martín Miguel, Fuchs, Benjamin, Fujii, Toshihiro, García, Beatriz, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D, Guardincerri, Yann, Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A, Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E, Hill, Gary C, Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A, Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Kégl, Balazs, Keilhauer, Bianca, Keivani, Azadeh, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Krömer, Oliver, Kuempel, Daniel, Kunka, Norbert, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lu, Lu, Lucero, Agustin, Malacari, Max, Maldera, Simone, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martin, Lilian, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurel, Detlef, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Meyhandan, Rishi, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A, Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A, Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Mussa, Roberto, Navarra, Gianni, Navarro, Jose Luis, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Nguyen, Phong H, Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Purrello, Victor, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Revenu, Benoît, Ridky, Jan, Riggi, Simone, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Fernandez, Gonzalo Rodriguez, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J, Saftoiu, Alexandra, Salamida, Francesco, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schiffer, Peter, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G, Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C, Sidelnik, Iván, Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sorokin, J, Squartini, Ruben, Srivastava, Yogendra N, Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Suomijärvi, Tiina, Supanitsky, A Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Tiffenberg, Javier, Timmermans, Charles, Peixoto, Carlos J Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R, Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zhu, Yue, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Neutrinos in the cosmic ray flux with energies near 1 EeV and above are detectable with the Surface Detector array of the Pierre Auger Observatory. We report here on searches through Auger data from 1 January 2004 until 20 June 2013. No neutrino candidates were found, yielding a limit to the diffuse flux of ultra-high energy neutrinos that challenges the Waxman-Bahcall bound predictions. Neutrino identification is attempted using the broad time-structure of the signals expected in the SD stations, and is efficiently done for neutrinos of all flavors interacting in the atmosphere at large zenith angles, as well as for "Earth-skimming" neutrino interactions in the case of tau neutrinos. In this paper the searches for downward-going neutrinos in the zenith angle bins $60^\circ-75^\circ$ and $75^\circ-90^\circ$ as well as for upward-going neutrinos, are combined to give a single limit. The $90\%$ C.L. single-flavor limit to the diffuse flux of ultra-high energy neutrinos with an $E^{-2}$ spectrum in the energy range $1.0 \times 10^{17}$ eV - $2.5 \times 10^{19}$ eV is $E_\nu^2 dN_\nu/dE_\nu < 6.4 \times 10^{-9}~ {\rm GeV~ cm^{-2}~ s^{-1}~ sr^{-1}}$., Comment: Replaced with published version. Added journal reference and DOI

Published
2015
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31. Measurement of the cosmic ray spectrum above $4{\times}10^{18}$ eV using inclined events detected with the Pierre Auger Observatory

Author

The Pierre Auger Collaboration, Aab, Alexander, Abreu, Pedro, Aglietta, Marco, Ahn, Eun-Joo, Samarai, Imen Al, Albuquerque, Ivone, Allekotte, Ingomar, Allison, Patrick, Almela, Alejandro, Castillo, Jesus Alvarez, Alvarez-Muñiz, Jaime, Batista, Rafael Alves, Ambrosio, Michelangelo, Aminaei, Amin, Anchordoqui, Luis, Andringa, Sofia, Aramo, Carla, Aranda, Victor Manuel, Arqueros, Fernando, Arsene, Nicusor, Asorey, Hernán Gonzalo, Assis, Pedro, Aublin, Julien, Ave, Maximo, Avenier, Michel, Avila, Gualberto, Awal, Nafiun, Badescu, Alina Mihaela, Barber, Kerri B, Bäuml, Julia, Baus, Colin, Beatty, Jim, Becker, Karl Heinz, Bellido, Jose A, Berat, Corinne, Bertaina, Mario Edoardo, Bertou, Xavier, Biermann, Peter, Billoir, Pierre, Blaess, Simon G, Blanco, Alberto, Blanco, Miguel, Bleve, Carla, Blümer, Hans, Boháčová, Martina, Boncioli, Denise, Bonifazi, Carla, Borodai, Nataliia, Brack, Jeffrey, Brancus, Iliana, Bridgeman, Ariel, Brogueira, Pedro, Brown, William C, Buchholz, Peter, Bueno, Antonio, Buitink, Stijn, Buscemi, Mario, Caballero-Mora, Karen S, Caccianiga, Barbara, Caccianiga, Lorenzo, Candusso, Marina, Caramete, Laurentiu, Caruso, Rossella, Castellina, Antonella, Cataldi, Gabriella, Cazon, Lorenzo, Cester, Rosanna, Chavez, Alan G, Chiavassa, Andrea, Chinellato, Jose Augusto, Chudoba, Jiri, Cilmo, Marco, Clay, Roger W, Cocciolo, Giuseppe, Colalillo, Roberta, Coleman, Alan, Collica, Laura, Coluccia, Maria Rita, Conceição, Ruben, Contreras, Fernando, Cooper, Mathew J, Cordier, Alain, Coutu, Stephane, Covault, Corbin, Cronin, James, Dallier, Richard, Daniel, Bruno, Dasso, Sergio, Daumiller, Kai, Dawson, Bruce R, de Almeida, Rogerio M, de Jong, Sijbrand J, De Mauro, Giuseppe, Neto, Joao de Mello, De Mitri, Ivan, de Oliveira, Jaime, de Souza, Vitor, del Peral, Luis, Deligny, Olivier, Dembinski, Hans, Dhital, Niraj, Di Giulio, Claudio, Di Matteo, Armando, Diaz, Johana Chirinos, Castro, Mary Lucia Díaz, Diogo, Francisco, Dobrigkeit, Carola, Docters, Wendy, D'Olivo, Juan Carlos, Dorofeev, Alexei, Hasankiadeh, Qader Dorosti, Dova, Maria Teresa, Ebr, Jan, Engel, Ralph, Erdmann, Martin, Erfani, Mona, Escobar, Carlos O, Espadanal, Joao, Etchegoyen, Alberto, Falcke, Heino, Fang, Ke, Farrar, Glennys, Fauth, Anderson, Fazzini, Norberto, Ferguson, Andrew P, Fernandes, Mateus, Fick, Brian, Figueira, Juan Manuel, Filevich, Alberto, Filipčič, Andrej, Fox, Brendan, Fratu, Octavian, Freire, Martín Miguel, Fuchs, Benjamin, Fujii, Toshihiro, García, Beatriz, Garcia-Pinto, Diego, Gate, Florian, Gemmeke, Hartmut, Gherghel-Lascu, Alexandru, Ghia, Piera Luisa, Giaccari, Ugo, Giammarchi, Marco, Giller, Maria, Głas, Dariusz, Glaser, Christian, Glass, Henry, Golup, Geraldina, Berisso, Mariano Gómez, Vitale, Primo F Gómez, González, Nicolás, Gookin, Ben, Gordon, Jacob, Gorgi, Alessio, Gorham, Peter, Gouffon, Philippe, Griffith, Nathan, Grillo, Aurelio, Grubb, Trent D, Guarino, Fausto, Guedes, Germano, Hampel, Matías Rolf, Hansen, Patricia, Harari, Diego, Harrison, Thomas A, Hartmann, Sebastian, Harton, John, Haungs, Andreas, Hebbeker, Thomas, Heck, Dieter, Heimann, Philipp, Herve, Alexander E, Hill, Gary C, Hojvat, Carlos, Hollon, Nicholas, Holt, Ewa, Homola, Piotr, Hörandel, Jörg, Horvath, Pavel, Hrabovský, Miroslav, Huber, Daniel, Huege, Tim, Insolia, Antonio, Isar, Paula Gina, Jandt, Ingolf, Jansen, Stefan, Jarne, Cecilia, Johnsen, Jeffrey A, Josebachuili, Mariela, Kääpä, Alex, Kambeitz, Olga, Kampert, Karl Heinz, Kasper, Peter, Katkov, Igor, Kégl, Balazs, Keilhauer, Bianca, Keivani, Azadeh, Kemp, Ernesto, Kieckhafer, Roger, Klages, Hans, Kleifges, Matthias, Kleinfeller, Jonny, Krause, Raphael, Krohm, Nicole, Krömer, Oliver, Kuempel, Daniel, Kunka, Norbert, LaHurd, Danielle, Latronico, Luca, Lauer, Robert, Lauscher, Markus, Lautridou, Pascal, Coz, Sandra Le, Lebrun, Didier, Lebrun, Paul, de Oliveira, Marcelo Augusto Leigui, Letessier-Selvon, Antoine, Lhenry-Yvon, Isabelle, Link, Katrin, Lopes, Luis, López, Rebeca, Casado, Aida López, Louedec, Karim, Lu, Lu, Lucero, Agustin, Malacari, Max, Maldera, Simone, Mallamaci, Manuela, Maller, Jennifer, Mandat, Dusan, Mantsch, Paul, Mariazzi, Analisa, Marin, Vincent, Mariş, Ioana, Marsella, Giovanni, Martello, Daniele, Martin, Lilian, Martinez, Humberto, Bravo, Oscar Martínez, Martraire, Diane, Meza, Jimmy Masías, Mathes, Hermann-Josef, Mathys, Sebastian, Matthews, James, Matthews, John, Matthiae, Giorgio, Maurel, Detlef, Maurizio, Daniela, Mayotte, Eric, Mazur, Peter, Medina, Carlos, Medina-Tanco, Gustavo, Meissner, Rebecca, Mello, Victor, Melo, Diego, Menshikov, Alexander, Messina, Stefano, Meyhandan, Rishi, Micheletti, Maria Isabel, Middendorf, Lukas, Minaya, Ignacio A, Miramonti, Lino, Mitrica, Bogdan, Molina-Bueno, Laura, Mollerach, Silvia, Montanet, François, Morello, Carlo, Mostafá, Miguel, Moura, Celio A, Muller, Marcio Aparecido, Müller, Gero, Müller, Sarah, Mussa, Roberto, Navarra, Gianni, Navas, Sergio, Necesal, Petr, Nellen, Lukas, Nelles, Anna, Neuser, Jens, Newton, David, Nguyen, Phong H, Niculescu-Oglinzanu, Mihai, Niechciol, Marcus, Niemietz, Lukas, Niggemann, Tim, Nitz, Dave, Nosek, Dalibor, Novotny, Vladimir, Nožka, Lyberis, Ochilo, Livingstone, Oikonomou, Foteini, Olinto, Angela, Olmos-Gilbaja, Victor, Pacheco, Noelia, Selmi-Dei, Daniel Pakk, Palatka, Miroslav, Pallotta, Juan, Papenbreer, Philipp, Parente, Gonzalo, Parra, Alejandra, Paul, Thomas, Pech, Miroslav, Pękala, Jan, Pelayo, Rodrigo, Pepe, Iuri, Perrone, Lorenzo, Petermann, Emily, Peters, Christine, Petrera, Sergio, Petrov, Yevgeniy, Phuntsok, Jamyang, Piegaia, Ricardo, Pierog, Tanguy, Pieroni, Pablo, Pimenta, Mário, Pirronello, Valerio, Platino, Manuel, Plum, Matthias, Porcelli, Alessio, Porowski, Czeslaw, Prado, Raul Ribeiro, Privitera, Paolo, Prouza, Michael, Purrello, Victor, Quel, Eduardo J, Querchfeld, Sven, Quinn, Sean, Rautenberg, Julian, Ravel, Olivier, Ravignani, Diego, Revenu, Benoît, Ridky, Jan, Riggi, Simone, Risse, Markus, Ristori, Pablo, Rizi, Vincenzo, de Carvalho, Washington Rodrigues, Fernandez, Gonzalo Rodriguez, Rojo, Jorge Rubén Rodriguez, Rodríguez-Frías, Maria Dolores, Rogozin, Dmytro, Rosado, Jaime, Roth, Markus, Roulet, Esteban, Rovero, Adrian, Saffi, Steven J, Saftoiu, Alexandra, Salamida, Francesco, Salazar, Humberto, Saleh, Ahmed, Greus, Francisco Salesa, Salina, Gaetano, Sánchez, Federico, Sanchez-Lucas, Patricia, Santos, Edivaldo Moura, Santos, Eva, Sarazin, Fred, Sarkar, Biswaijt, Sarmento, Raul, Sato, Ricardo, Scarso, Carlos, Schauer, Markus, Scherini, Viviana, Schieler, Harald, Schiffer, Peter, Schmidt, David, Scholten, Olaf, Schoorlemmer, Harm, Schovánek, Petr, Schröder, Frank G, Schulz, Alexander, Schulz, Johannes, Schumacher, Johannes, Sciutto, Sergio, Segreto, Alberto, Settimo, Mariangela, Shadkam, Amir, Shellard, Ronald C, Sidelnik, Iván, Sigl, Guenter, Sima, Octavian, Śmiałkowski, Andrzej, Šmída, Radomir, Snow, Gregory, Sommers, Paul, Sorokin, J, Squartini, Ruben, Srivastava, Yogendra N, Stanca, Denis, Stanič, Samo, Stapleton, James, Stasielak, Jaroslaw, Stephan, Maurice, Stutz, Anne, Suarez, Federico, Suomijärvi, Tiina, Supanitsky, A Daniel, Sutherland, Michael, Swain, John, Szadkowski, Zbigniew, Taborda, Oscar Alejandro, Tapia, Alex, Tepe, Andreas, Theodoro, Vanessa Menezes, Timmermans, Charles, Peixoto, Carlos J Todero, Toma, Gabriel, Tomankova, Lenka, Tomé, Bernardo, Tonachini, Aurelio, Elipe, Guillermo Torralba, Machado, Diego Torres, Travnicek, Petr, Ulrich, Ralf, Unger, Michael, Urban, Martin, Galicia, Jose F Valdés, Valiño, Ines, Valore, Laura, van Aar, Guus, van Bodegom, Patrick, Berg, Ad M van den, van Velzen, Sjoert, van Vliet, Arjen, Varela, Enrique, Cárdenas, Bernardo Vargas, Varner, Gary, Vasquez, Rafael, Vázquez, Jose R, Vázquez, Ricardo, Veberič, Darko, Verzi, Valerio, Vicha, Jakub, Videla, Mariela, Villaseñor, Luis, Vlcek, Brian, Vorobiov, Serguei, Wahlberg, Hernan, Wainberg, Oscar, Walz, David, Watson, Alan, Weber, Marc, Weidenhaupt, Klaus, Weindl, Andreas, Werner, Felix, Widom, Allan, Wiencke, Lawrence, Wilczyński, Henryk, Winchen, Tobias, Wittkowski, David, Wundheiler, Brian, Wykes, Sarka, Yang, Lili, Yapici, Tolga, Yushkov, Alexey, Zas, Enrique, Zavrtanik, Danilo, Zavrtanik, Marko, Zepeda, Arnulfo, Zhu, Yue, Zimmermann, Benedikt, Ziolkowski, Michael, and Zuccarello, Francesca

Subjects
Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV., Comment: Replaced with published version. Added journal reference and DOI

Published
2015
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32. Status of the Silicon Photomultiplier Telescope FAMOUS for the Fluorescence Detection of UHECRs

Author

Niggemann, Tim, Assis, Pedro, Brogueira, Pedro, Bueno, Antonio, Eichler, Hans Michael, Ferreira, Miguel, Hebbeker, Thomas, Lauscher, Markus, Mendes, Luís, Middendorf, Lukas, Navas, Sergio, Peters, Christine, Pimenta, Mário, Ruiz, Angel, Schumacher, Johannes, and Stephan, Maurice

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

An established technique for the measurement of ultra-high-energy-cosmic-rays is the detection of the fluorescence light induced in the atmosphere of the Earth, by means of telescopes equipped with photomultiplier tubes. Silicon photomultipliers (SiPMs) promise an increase in the photon detection efficiency which outperforms conventional photomultiplier tubes. In combination with their compact package, a moderate bias voltage of several ten volt and single photon resolution, the use of SiPMs can improve the energy and spatial resolution of air fluorescence measurements, and lead to a gain in information on the primary particle. Though, drawbacks like a high dark-noise-rate and a strong temperature dependency have to be managed. FAMOUS is a refracting telescope prototype instrumented with 64 SiPMs of which the main optical element is a Fresnel lens of 549.7 mm diameter and 502.1 mm focal length. The sensitive area of the SiPMs is increased by a special light collection system consisting of Winston cones. The total field of view of the telescope is approximately 12 $^\circ$. The frontend electronics automatically compensates for the temperature dependency of the SiPMs and will provide trigger information for the readout. Already for this prototype, the Geant4 detector simulation indicates full detection efficiency of extensive air showers of $E=10^{18}\,\text{eV}$ up to a distance of 6 km. We present the first working version of FAMOUS with a focal plane prototype providing seven active pixels., Comment: 4 pages, 6 figures. Proceedings of the 33rd International Cosmic Ray Conference (ICRC), Rio de Janeiro, Brazil, 2-9 July 2013

Published
2015

33. National mapping and estimation of forest area by dominant tree species using Sentinel-2 data

Author

Breidenbach, Johannes, Waser, Lars T., Debella-Gilo, Misganu, Schumacher, Johannes, Rahlf, Johannes, Hauglin, Marius, Puliti, Stefano, and Astrup, Rasmus

Subjects
Sustainable forestry -- Methods, Machine learning -- Usage, Forests and forestry -- Models -- Norway, Satellite imaging -- Usage, Earth sciences
Abstract

Nation-wide Sentinel-2 mosaics were used with National Forest Inventory (NFI) plot data for modelling and subsequent mapping of spruce-, pine-, and deciduous-dominated forest in Norway at a 16 m * 16 m resolution. The accuracies of the best model ranged between 74% for spruce and 87% for deciduous forest. An overall accuracy of 90% was found on stand level using independent data from more than 42 000 stands. Errors mostly resulting from a forest mask reduced the model accuracies by ~10%. The produced map was subsequently used to generate model-assisted (MA) and post stratified (PS) estimates of species-specific forest area. At the national level, efficiencies of the estimates increased by 20% to 50% for MA and up to 90% for PS. Greater minimum numbers of observations constrained the use of PS. For MA estimates of municipalities, efficiencies improved by up to a factor of 8 but were sometimes also less than 1. PS estimates were always equally as or more precise than direct and MA estimates but were applicable in fewer municipalities. The tree species prediction map is part of the Norwegian forest resource map and is used, among others, to improve maps of other variables of interest such as timber volume and biomass. Key words: National Forest Inventory, model-assisted estimation, poststratification, machine learning, small area estimation., Resume : Des mosaiques Sentinel-2 a l'echelle nationale ont ete utilisees avec des donnees de parcelles de l'inventaire forestier national (IFN) pour la modelisation et, par la suite, pour la [...]

Published
2021
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34. Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes.

Author

Giel, Ann-Sophie, Bigge, Jessica, Schumacher, Johannes, Maj, Carlo, and Dasmeh, Pouria

Subjects
GENE expression, NATURAL selection, GENETIC correlations, CORONARY artery disease, GENOME-wide association studies
Abstract

Understanding the expression level and evolutionary rate of associated genes with human polygenic diseases provides crucial insights into their disease-contributing roles. In this work, we leveraged genome-wide association studies (GWASs) to investigate the relationship between the genetic association and both the evolutionary rate (d N /d S) and expression level of human genes associated with the two polygenic diseases of schizophrenia and coronary artery disease. Our findings highlight a distinct variation in these relationships between the two diseases. Genes associated with both diseases exhibit a significantly greater variance in evolutionary rate compared to those implicated in monogenic diseases. Expanding our analyses to 4,756 complex traits in the GWAS atlas database, we unraveled distinct trait categories with a unique interplay among the evolutionary rate, expression level, and genetic association of human genes. In most polygenic traits, highly expressed genes were more associated with the polygenic phenotypes compared to lowly expressed genes. About 69% of polygenic traits displayed a negative correlation between genetic association and evolutionary rate, while approximately 30% of these traits showed a positive correlation between genetic association and evolutionary rate. Our results demonstrate the presence of a spectrum among complex traits, shaped by natural selection. Notably, at opposite ends of this spectrum, we find metabolic traits being more likely influenced by purifying selection, and immunological traits that are more likely shaped by positive selection. We further established the polygenic evolution portal (evopolygen.de) as a resource for investigating relationships and generating hypotheses in the field of human polygenic trait evolution. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Impact of “Electronic Patient Reported Outcomes” (ePRO) on Unplanned Consultations and Hospitalizations in Patients With Cancer Undergoing Systemic Therapy: Results of the Patient Reported Outcome (PRO) Study Compared With Matched Retrospective Data (Preprint)

Author

Trojan, Andreas, primary, Kühne, Christian, additional, Kiessling, Michael, additional, Schumacher, Johannes, additional, Dröse, Stefan, additional, Singer, Christian, additional, Jackisch, Christian, additional, Thomssen, Christoph, additional, and Kullak-Ublick, Gerd A, additional

Published
2023
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40. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study

Author

Dong, Jing, Gharahkhani, Puya, Chow, Wong-Ho, Gammon, Marilie D., Liu, Geoffrey, Caldas, Carlos, Wu, Anna H., Ye, Weimin, Onstad, Lynn, Anderson, Lesley A., Bernstein, Leslie, Pharoah, Paul D., Risch, Harvey A., Corley, Douglas A., Fitzgerald, Rebecca C., Iyer, Prasad G., Reid, Brian J., Lagergren, Jesper, Shaheen, Nicholas J., Vaughan, Thomas L., MacGregor, Stuart, Love, Sharon, Palles, Claire, Tomlinson, Ian, Gockel, Ines, May, Andrea, Gerges, Christian, Anders, Mario, Böhmer, Anne C., Becker, Jessica, Kreuser, Nicole, Thieme, Rene, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Schmidt, Claudia, Izbicki, Jakob R., Hölscher, Arnulf H., Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Mayershofer, Rupert, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M., Moebus, Susanne, Knapp, Michael, Peters, Wilbert H.M., Neuhaus, Horst, Rösch, Thomas, Ell, Christian, Jankowski, Janusz, Schumacher, Johannes, Neale, Rachel E., Whiteman, David C., and Thrift, Aaron P.

Published
2019
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42. The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases.

Author

Koebbe, Laura L., Hess, Timo, Giel, Ann-Sophie, Bigge, Jessica, Gehlen, Jan, Schueller, Vitalia, Geppert, Michael, Dumoulin, Franz Ludwig, Heller, Joerg, Schepke, Michael, Plaßmann, Dominik, Vieth, Michael, Venerito, Marino, Schumacher, Johannes, and Maj, Carlo

Subjects
GENETIC regulation, GENE expression, LOCUS (Genetics), BODY composition, TRANSCRIPTOMES, PLANT protection
Abstract

Tissue-specific gene expression and gene regulation lead to a better understanding of tissue-specific physiology and pathophysiology. We analyzed the transcriptome and genetic regulatory profiles of two distinct gastric sites, corpus and antrum, to identify tissue-specific gene expression and its regulation. Gastric corpus and antrum mucosa biopsies were collected during routine gastroscopies from up to 431 healthy individuals. We obtained genotype and transcriptome data and performed transcriptome profiling and expression quantitative trait locus (eQTL) studies. We further used data from genome-wide association studies (GWAS) of various diseases and traits to partition their heritability and to perform transcriptome-wide association studies (TWAS). The transcriptome data from corpus and antral mucosa highlights the heterogeneity of gene expression in the stomach. We identified enriched pathways revealing distinct and common physiological processes in gastric corpus and antrum. Furthermore, we found an enrichment of the single nucleotide polymorphism (SNP)-based heritability of metabolic, obesity-related, and cardiovascular traits and diseases by considering corpus- and antrum-specifically expressed genes. Particularly, we could prioritize gastric-specific candidate genes for multiple metabolic traits, like NQO1 which is involved in glucose metabolism, MUC1 which contributes to purine and protein metabolism or RAB27B being a regulator of weight and body composition. Our findings show that gastric corpus and antrum vary in their transcriptome and genetic regulatory profiles indicating physiological differences which are mostly related to digestion and epithelial protection. Moreover, our findings demonstrate that the genetic regulation of the gastric transcriptome is linked to biological mechanisms associated with metabolic, obesity-related, and cardiovascular traits and diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Comparison of the Real-World Reporting of Symptoms and Well-Being for the HER2-Directed Trastuzumab Biosimilar Ogivri With Registry Data for Herceptin in the Treatment of Breast Cancer: Prospective Observational Study (OGIPRO) of Electronic Patient-Reported Outcomes (Preprint)

Author

Trojan, Andreas, primary, Roth, Sven, additional, Atassi, Ziad, additional, Kiessling, Michael, additional, Zenhaeusern, Reinhard, additional, Kadvany, Yannick, additional, Schumacher, Johannes, additional, Kullak-Ublick, Gerd A, additional, Aapro, Matti, additional, and Eniu, Alexandru, additional

Published
2023
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44. Comparing HER2-directed biosimilar Ogivri® with registry data for Herceptin™ in the treatment of breast cancer by real-world reporting of symptoms and well-being using electronic patient-reported outcome (ePRO): results of the observational OGIPRO study. (Preprint)

Author

Trojan, Andreas, primary, Roth, Sven, additional, Atassi, Ziad, additional, Kiessling, Michael K., additional, Zenhäusern, Reinhard, additional, Kadvany, Yannick, additional, Schumacher, Johannes, additional, Kullak-Ublick, Gerd A., additional, Aapro, Matti, additional, and Eniu, Alexandru, additional

Published
2023
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47. Whole-exome sequencing of 81 individuals from 27 multiply affected bipolar disorder families

Author

Forstner, Andreas J., Fischer, Sascha B., Schenk, Lorena M., Strohmaier, Jana, Maaser-Hecker, Anna, Reinbold, Céline S., Sivalingam, Sugirthan, Hecker, Julian, Streit, Fabian, Degenhardt, Franziska, Witt, Stephanie H., Schumacher, Johannes, Thiele, Holger, Nürnberg, Peter, Guzman-Parra, José, Orozco Diaz, Guillermo, Auburger, Georg, Albus, Margot, Borrmann-Hassenbach, Margitta, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez Perez, Fermin, Haro González, Jesus, Rivas, Fabio, Mayoral, Fermin, Bauer, Michael, Pfennig, Andrea, Reif, Andreas, Herms, Stefan, Hoffmann, Per, Pirooznia, Mehdi, Goes, Fernando S., Rietschel, Marcella, Nöthen, Markus M., and Cichon, Sven

Published
2020
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48. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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50. Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity

Author

Häder, Antje, primary, Schäuble, Sascha, additional, Gehlen, Jan, additional, Thielemann, Nadja, additional, Buerfent, Benedikt C., additional, Schüller, Vitalia, additional, Hess, Timo, additional, Wolf, Thomas, additional, Schröder, Julia, additional, Weber, Michael, additional, Hünniger, Kerstin, additional, Löffler, Jürgen, additional, Vylkova, Slavena, additional, Panagiotou, Gianni, additional, Schumacher, Johannes, additional, and Kurzai, Oliver, additional

Published
2023
Full Text
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