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6. MP18-09 MORE THAN MEETS THE EYE: EVALUATING THE EFFECT OF NOVEL NEOADJUVANT ANDROGEN SIGNALING INHIBITION ON PROSTATE MULTIPARAMETRIC MRI

Author

Koller, Christopher R., primary, Parikh, Sahil H., additional, Schuppe, Kyle C., additional, Hesswani, Charles, additional, Azar, William S., additional, Kenigsberg, Alexander P., additional, Gelikman, David G., additional, Mendhiratta, Neil, additional, Azari, Sarah, additional, Nethala, Daniel, additional, Gold, Samuel, additional, Gurram, Sandeep, additional, Madan, Ravi A., additional, Karzai, Fatima, additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2024
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7. MP30-01 A NEW LOOK: THE PROMISING USE OF 3-DIMENSIONAL QUANTITATIVE TRANSMISSION ULTRASOUND TOMOGRAPHY FOR THE DETECTION OF PROSTATE CANCER AN EX VIVO STUDY

Author

Parikh, Sahil H., primary, Hesswani, Charles, additional, Azar, William S., additional, Koller, Christopher R., additional, Schuppe, Kyle C., additional, Kenigsberg, Alexander P., additional, Mendhiratta, Neil, additional, Azari, Sarah, additional, Nethala, Daniel, additional, Wu, Yixuan, additional, Wiskin, James, additional, Boctor, Emad, additional, Klock, John, additional, Wood, Bradford, additional, Gurram, Sandeep, additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2024
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8. MP70-02 DOES PRE-PROSTATECTOMY MAGNETIC RESONANCE IMAGING REDUCE RACIAL DISPARITIES IN ONCOLOGIC OUTCOMES FOR AFRICAN AMERICAN PATIENTS: A PROPENSITY SCORE-MATCHED ANALYSIS

Author

Schuppe, Kyle C., primary, Koller, Christopher, additional, Parikh, Sahil, additional, Hesswani, Charles, additional, Azar, William S., additional, Azari, Sarah, additional, Kenigsberg, Alexander P., additional, Rathi, Nityam, additional, Hyman, Jason, additional, Gelikman, David G., additional, Mendhiratta, Neil, additional, Nethala, Daniel, additional, Gurram, Sandeep, additional, Merino, Maria, additional, Choyke, Peter, additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2024
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9. MP70-10 DRIVERS AND BARRIERS TO ACCESSING PROSTATE SPECIFIC ANTIGEN SCREENING FOR EARLY DETECTION OF PROSTATE CANCER AMONG BLACK MEN

Author

Lee, Jenney R., primary, Morehead, Dante’, additional, Young, Ben, additional, Tolbert, Victor, additional, Masembe, John, additional, Britt, Garrett, additional, Neuenschwander, Lars, additional, Schuppe, Kyle, additional, Pelman, Richard, additional, Johnson, Debi, additional, Kim, Sung Min, additional, Burrola-Mendez, Yohali, additional, Wolff, Erika M., additional, Gore, John L., additional, and Nyame, Yaw A., additional

Published
2024
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10. PD33-06 RENAL SURGERY FOLLOWING HIF2ALPHA; ANTAGONIST THERAPY: GROWTH KINETICS AND SURGICAL OUTCOMES

Author

Nethala, Daniel, primary, Hyman, Jason, additional, Rathi, Nityam, additional, Hsueh, Jessica, additional, Hesswani, Charles, additional, Koller, Christopher, additional, Kenigsberg, Alexander P., additional, Mendhiratta, Neil, additional, Lawson, Keith, additional, Parikh, Sahil, additional, Azar, William, additional, Schuppe, Kyle, additional, Vocke, Cathy, additional, Srinivasan, Ramaprasad, additional, Gurram, Sandeep, additional, Linehan, W. Marston, additional, and Ball, Mark W., additional

Published
2024
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11. MP43-06 IS IT TIME TO ABANDON THE TRANSRECTAL PROBE IN PROSTATE BIOPSY?

Author

Azar, William S., primary, Koller, Christopher R., additional, Parikh, Sahil H., additional, Hesswani, Charles, additional, Schuppe, Kyle C., additional, Azari, Sarah S., additional, Kenigsberg, Alexander P., additional, Mendhiratta, Neil, additional, Hyman, Jason, additional, Noun, Jibriel, additional, Siva, Jayant, additional, Nethala, Daniel, additional, Gelikman, David G., additional, Merino, Maria J., additional, Parnes, Howard S., additional, Wood, Bradford J., additional, Turkbey, Ismail Baris, additional, Gurram, Sandeep, additional, Xu, Sheng, additional, and Pinto, Peter A., additional

Published
2024
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12. PD18-03 NATURAL HISTORY OF METASTATIC RENAL CELL CARCINOMA (RCC) ASSOCIATED WITH HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA (HLRCC)

Author

Nethala, Daniel, primary, Rathi, Nityam, additional, Hyman, Jason, additional, Hsueh, Jessica, additional, Hesswani, Charles, additional, Koller, Christopher, additional, Kenigsberg, Alexander P., additional, Mendhiratta, Neil, additional, Lawson, Keith, additional, Parikh, Sahil, additional, Azar, William, additional, Schuppe, Kyle, additional, Vocke, Cathy, additional, Ball, Mark W., additional, Montenegro, Gabriela Bravo, additional, Gurram, Sandeep, additional, Linehan, W. Marston, additional, and Srinivasan, Ramaprasad, additional

Published
2024
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13. MP31-08 TRANSPERINEAL VERSUS TRANSRECTAL MRI-US FUSION TARGETED PROSTATE BIOPSIES FOR APICAL LESIONS

Author

Siva, Jayant, primary, Mendhiratta, Neil, additional, Kenigsberg, Alexander, additional, Schuppe, Kyle C., additional, Azar, William S., additional, Parikh, Sahil H., additional, Koller, Christopher, additional, Hesswani, Charles, additional, Merino, Maria, additional, Wood, Bradford, additional, Turkbey, Baris, additional, Gurram, Sandeep, additional, and Pinto, Peter A., additional

Published
2024
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14. MP18-15 THE IMPACT OF MAGNETIC RESONANCE IMAGING-DETECTED ZONAL LOCATION ON PROSTATE CANCER RECURRENCE: IMPLICATIONS FOR PREOPERATIVE RISK STRATIFICATION

Author

Schuppe, Kyle C., primary, Kenigsberg, Alexander P., additional, Azar, William S., additional, Hesswani, Charles, additional, Parikh, Sahil H., additional, Koller, Christopher, additional, Mendhiratta, Neil, additional, Azari, Sarah, additional, Gelikman, David G., additional, Nethala, Daniel, additional, Gurram, Sandeep, additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2024
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16. MP07-18 EVALUATION OF A BIPARAMETRIC MRI AI ALGORITHM FOR THE DETECTION OF PROSTATE CANCER USING SPATIAL ANNOTATIONS ON WHOLEMOUNT PROSTATE PATHOLOGY

Author

Hesswani, Charles, primary, Yilmaz, Enis C., additional, Harmon, Stephanie A., additional, Gelikman, David G., additional, Koller, Christopher R., additional, Parikh, Sahil H., additional, Schuppe, Kyle C., additional, Azar, William S., additional, Nethala, Daniel, additional, Mendhiratta, Neil, additional, Kenigsberg, Alexander P., additional, Gurram, Sandeep, additional, Turkbey, Baris, additional, and Pinto, Peter A., additional

Published
2024
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17. TRANSPERINEAL VERSUS TRANSRECTAL MRI-US FUSION TARGETED PROSTATE BIOPSIES FOR APICAL LESIONS

Author

Siva, Jayant, primary, Mendhiratta, Neil, additional, Kenigsberg, Alexander P., additional, Schuppe, Kyle, additional, Azar, William, additional, Parikh, Sahil, additional, Hesswani, Charles, additional, Koller, Christopher, additional, Merino, Maria, additional, Wood, Bradford J., additional, Turkbey, Baris, additional, Gurram, Sandeep, additional, and Pinto, Peter A., additional

Published
2024
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18. FOCAL THERAPY ELIGIBILITY: AN EVALUATION OF INITIAL AND CONTINUED CANDIDACY FOR FOCAL THERAPY IN A GRADE GROUP 2 ACTIVE SURVEILLANCE COHORT

Author

Mason, J. Bradley, primary, Azari, Sarah, additional, Kenigsberg, Alex P., additional, Blake, Zoë, additional, Nemirovsky, Daniel R., additional, Koller, Christopher, additional, Parikh, Sahil, additional, Azar, William, additional, Schuppe, Kyle, additional, Hesswani, Charles, additional, Mendhiratta, Neil, additional, Nethala, Daniel, additional, Merino, Maria, additional, Choyke, Peter L., additional, Parnes, Howard L., additional, Gurram, Sandeep, additional, Turkbey, Baris, additional, Wood, Bradford, additional, Pinto, Peter A., additional, and Mezhiritsky, Vladimir, additional

Published
2024
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19. CLINICAL OUTCOMES OF PATIENTS ON ACTIVE SURVEILLANCE FOR LOW-RISK PROSTATE CANCER WITH SMALL INDEX LESIONS ON MRI

Author

Siva, Jayant, primary, Mendhiratta, Neil, additional, Azar, William, additional, Parikh, Sahil, additional, Schuppe, Kyle, additional, Kenigsberg, Alexander P., additional, Koller, Christopher, additional, Hesswani, Charles, additional, Merino, Maria, additional, Wood, Bradford J., additional, Turkbey, Baris, additional, Gurram, Sandeep, additional, Pinto, Peter A., additional, and Pillai, Anjali, additional

Published
2024
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20. IMPACT OF PI-RADS 5 LESIONS ON ACTIVE SURVEILLANCE FOR GRADE GROUP 1

Author

Azari, Sarah, primary, Mason, J. Bradley, additional, Kenigsberg, Alexander P., additional, Koller, Christopher, additional, Parikh, Sahil, additional, Azar, William, additional, Schuppe, Kyle, additional, Siva, Jayant, additional, Hesswani, Charles, additional, Mendhiratta, Neil, additional, Nethala, Daniel, additional, Merino, Maria, additional, Wood, Bradford J., additional, Choyke, Peter L., additional, Parnes, Howard L., additional, Gurram, Sandeep, additional, Turkbey, Baris, additional, Pinto, Peter A., additional, Blake, Zoë, additional, Nemirovsky, Daniel R., additional, and Mezhiritsky, Vladimir, additional

Published
2024
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25. Safety Aspects and Rational Use of Testosterone Undecanoate in the Treatment of Testosterone Deficiency: Clinical Insights

Author

Campbell,Katherine, Muthigi,Akhil, Ghomeshi,Armin, Schuppe,Kyle, Sandler,Max D, Ramasamy,Ranjith, Campbell,Katherine, Muthigi,Akhil, Ghomeshi,Armin, Schuppe,Kyle, Sandler,Max D, and Ramasamy,Ranjith

Abstract

Katherine Campbell,1 Akhil Muthigi,1 Armin Ghomeshi,2 Kyle Schuppe,3 Max D Sandler,4 Ranjith Ramasamy1 1Desai Sethi Urology Institute, University of Miami, Miami, Fl, 33136, USA; 2Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33199, USA; 3Washington State University Elson S. Floyd College of Medicine, Spokane, WA, 99202-2131, USA; 4University of Miami Miller of Medicine, Miami, Fl, USACorrespondence: Ranjith Ramasamy, Desai Sethi Urology Institute, University of Miami, 1120 NW 14th St, Miami, Fl, 33136, USA, Tel +1 305-243-6090, Email ranjithrama@gmail.comAbstract: Testosterone deficiency is diagnosed by a serum total testosterone level below 300 ng/dL in combination with symptoms such as decreased energy and libido. These symptoms can be ameliorated by restoring serum testosterone to the physiologic range with testosterone therapy (TT). There are numerous forms of testosterone therapy, such as injectable, transdermal, nasal, and subcutaneous applications. There are also multiple formulations of injection, such as testosterone cypionate, testosterone enanthate, and testosterone undecanoate. Testosterone undecanoate (TU) is a long-acting ester formulation of testosterone that can be provided in an injectable or oral form. Oral testosterone undecanoate is marketed as Andriol, Jatenzo, Tlando, and Kyzatrex. Oral TU provides a convenient option for many patients, which may increase compliance with TT. Injectable testosterone undecanoate is marketed as Aveed and Nebido. Injectable TT remains the most cost-effective therapeutic option and is appropriate for most patients as an initial therapy. This review describes the pharmacokinetics of these testosterone undecanoate products and provides a guide for prescribers using these medications. While many forms of testosterone are appropriate for TT, a patient-centered discussion focused on goals of care should best guide physician prescription of these medications.Keywords: testosterone, te

Published
2023

30. Seasonal Variation in Serum Testosterone Levels: Evidence from 2 Large Institutional Databases.

Author

Miller, David, Gurayah, Aaron, Weber, Alexander, Schuppe, Kyle, Zarli, Mohamadhusni, Dullea, Alexandra, Hwang, Kathleen, and Ramasamy, Ranjith

Subjects
TEMPERATURE, TESTOSTERONE, LIQUID chromatography, CROSS-sectional method, POPULATION geography, RETROSPECTIVE studies, REGRESSION analysis, SEASONS, T-test (Statistics), COMPARATIVE studies, MASS spectrometry, DESCRIPTIVE statistics, DATA analysis software, LONGITUDINAL method
Abstract

Objective: Seasonal variations in testosterone levels have been reported in some studies, but the results are inconsistent. In this study, we aimed to determine if clinically relevant seasonal variability in testosterone levels exists using a large cohort of men from 2 different institutions, 1 located in an area with seasons (Pittsburgh, Pa) and 1 without seasons (Miami, Fla). Methods: Using 2 institutional databases, testosterone levels were obtained for men ages 18-99 from 2010 to 2021 who had at least 2 morning testosterone levels drawn within a 2-year period. All samples were analyzed with liquid chromatography with tandem mass spectrometry. To avoid potential confounding by testosterone altering medications patients who were currently or previously on exogenous testosterone, endogenous testo stero ne-st imula ting medications, testo stero ne-su ppres sing medications, and aromatase inhibitors were excluded from the study. Results: There were 9495 and 16 171 total testosterone levels measured from Miami and Pittsburgh, respectively, with all men having 2 or more levels. There was no statistically significant variation in testosterone levels for the overall cohort in Pittsburgh or Miami, respectively. Additionally, when stratified by age group, no individual groups were found to have significant seasonal variability. Conclusion: Our findings suggest that although there is differing total testosterone levels between men who reside in 2 different climates, there is no significant variability in testosterone levels between seasons. Therefore, testosterone levels can be checked and interpreted without the need to account for the season during which they were drawn. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Contributors

Author

Aborode, Abdullahi Tunde, Abouhashem, Ahmed S., Abramovich, Dalhia, Adebisi, Yusuff Adebayo, Águila, Niurka Molina, Ahmed, Khabab Abbasher Hussien Mohamed, Ait Belkacem, Narimene, Aiyenuro, Ademola Emmanuel, Alcántara-Quintana, Luz Eugenia, Arcaro, Giovanna, Aswar, Manoj, Auriti, Cinzia, Awasthi, Snigdha, Azzazy, Hassan M.E., Banach, Maciej, Bansal, Vikas, Baral, Budhadev, Barcenilla, Fernando, Barcenilla-Guitard, Maria, Bashir, Dalia A., Basyoni, Nashwa Ismail, Bednarczyk, Robert A., Bérard, Anick, Bjørklund, Geir, Bordaquievich, Mayra, Borg, Bindi, Borkoles, Erika, Budak, Ferah, Burcher, Paul, Campbell, Katherine, Carter, Jessica, Chan, Kylie K.Y., Chen, Jia, Chisti, Mohammod Jobayer, Chukwu, Udochiamaka Amarauche, Chung, Gary Ka-Ki, Clavel, Iván, Cohen, Clay T., de Diego-Cabanes, Cinta, De Rose, Domenico Umberto, DeAnnuntis, Taylor, del Pozo-Niubo, Albert, Delgado, Artur Figueiredo, Di Profio, Elisabetta, Díaz de León-Martínez, Lorena, Dimitriou, Gabriel, dos Santos, Maria Lúcia Barbosa Maia, Elbaz, Ahmed A., Espart, Anna, Flores-Ramírez, Rogelio, Forcadell-Peris, María-José, Francis, Sarah L., Gasmi, Amin, Gatto, Marino, Gkentzi, Despoina, Gorgui, Jessica, Gribble, Karleen, Gruchoła, Małgorzata, Guarnieri, Gabriella, Guitard Quer, Alba, Guitard-Sein Echaluce, Luisa, Gupta, Dhruv S., Guzmán, María G., Gyamfi, Daniel, Ha, Kyoo-Man, Hatzidaki, Eleftheria, Henderson, Ariana C., Herrero, Yamila, Hozak, Svitlana, Iglesias-Soler, Eliseo, Ivanovska, Olha, Jakhmola, Shweta, Jessel, Rebecca H., Jha, Hem Chandra, Jimoh, Nafisat Dasola, Kacar, Sedat, Kashyap, Rahul, Khodamoradi, Kajal, Khosravizadeh, Zahra, Kim, Young T., Kızmaz, Muhammed Ali, Koblianska, Alla, Kodama, Kota, Kontou, Angeliki, Kulkarni, Nikhil, Kumar, Maushmi S., Kundu, Pratik, Kuss, Miguel Pedromingo, Lahoz, Ana Lúcia Capelari, Lazova, Snezhina, Ledesma, Braian, Lee, Ashley Sunjae, Lesseur, Corina, Lewek, Joanna, Li, Muzi, Licciardi, Paul V., Lionello, Federico, Lococo, Sara, López-Mendoza, Carlos Miguel, Maddaloni, Chiara, Maheshwari, Anu, Malek, Habib, Malek, Rafiaa, Małek, Łukasz A., Marrón, Honorato Ortiz, Martín-Luján, Francisco M., Mascolo, Cristina, Mazarakis, Nadia, Mazzoni, Beatriz Polisel, Meng, Xiangfei, Meral, Bekir Fatih, Miccoli, Stefano, Micetic, Becky, Mody, Kartik, Mohakud, Nirmal Kumar, Moore, Kendall, Mostafa, Aya, Muduli, Kartik, Naruse, Takashi, Nehaoua, Amine, Neira, Melanie, Nguyen, Kimberly H., Nine, Iván, Niwa, Makoto, Noor, Sadaf, Nozella, Camila, Nuzhat, Sharika, Ogunsola, Samuel, Okereke, Promise Udohchukwu, Onyeani, Chijioke Obiwe, Ortiz-Pinto, Maira Alejandra, Paccagnella, Omar, Parats, Alla, Parborell, Fernanda, Patel, Vinood B., Patro, Shubhransu, Pemde, Harish K., Polka, Nadiya, Preedy, Victor R., Procianoy, Guilherme Silveira, Rahman, Farah, Rajendram, Rajkumar, Ramasamy, Ranjith, Religa, Dorota, Rial-Vázquez, Jessica, Robillard, Christina L., Rodríguez, Elba Cruz, Rodríguez, Waldemar Baldoquin, Rosaria, Marchili Maria, Rout, Nikunj Kumar, Rúa-Alonso, María, Rudolph, Catherine S., Saber, Sherine K., Saini, Vaishali, Santana, Belkys María Galindo, Sarafidis, Kosmas, Sartain, Sarah E., Satué-Gracia, Eva M., Scanlon, Christina L., Schultz, Savannah, Schuppe, Kyle, Seiffert, Piotr, Semenova, Yuliya, Sen, Chandan K., Sengoku, Shintaro, Shen, Alice, Shinde, Milind, Shomuyiwa, Deborah Oluwaseun, Silveira, Rita C, Simsek, Abdurrahman, Singh, Kanhaiya, Singh, Vidit, Sławek-Czochra, Małgorzata, Spina, Giulia, Srivastava, Amit, Stankevych, Tetiana, Su, Yingying, Surma, Stanisław, Taymur, Bilge Dogan, Tekin, Arzu Bilge, Tenorio-Salazar, Ana Jared, Toh, Zheng Quan, Turner, Brianna J., Uche, Nneka Catherine, Vasudevan, Lavanya, Velikova, Tsvetelina, Verduci, Elvira, Vianello, Andrea, Vila-Córcoles, Angel, Villani, Alberto, Wade, Christine, Wang, Ming-Te, Ward, Jeremy D., Williams, Jahnea, Yamaguchi, Munekage, Yang, Xue, Yelizarova, Olena, Yeoh, Eng-Kiong, Zamberlan, Patrícia, Zarli, Mohammed, and Zuccotti, Gianvincenzo

Published
2024
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35. A survey of exposure to the use of Xiaflex for the treatment of Peyronie’s disease among United States urology residency programs

Author

Loloi, Justin, Schuppe, Kyle, Reddy, Raghuram V., Rahman, Farah, Bernstein, Ari, Reddy, Pritika, Kulkarni, Nikhil, Masterson, Thomas, and Ramasamy, Ranjith

Abstract

Xiaflex® (collagenase clostridium histolyticum) is a Food and Drug Administration-approved treatment for patients with Peyronie’s disease. Despite its approval and implementation, there is concern that urologists in training are offered minimal exposure to its use. Thus, the purpose of this study was to evaluate the exposure of urology residents to Peyronie’s disease and its management, particularly Xiaflex®. A Google Forms survey regarding the exposure of residents to Peyronie’s disease and use of Xiaflex® was created and disseminated through email to urology programs. Overall, 47 institutional responses were received. At 45 institutions (95.7%), residents receive training in directly evaluating and caring for patients with Peyronie’s disease. At 46 institutions (97.9%), residents receive training in observing and/or performing surgical procedures for Peyronie’s disease. Residents at 31 institutions (66.0%) receive observational or procedural training for non-surgical management of Peyronie’s disease, specifically Xiaflex®. Residents receive non-surgical training from an academic faculty who is fellowship trained in sexual medicine at 25 institutions and an academic faculty not trained in sexual medicine at six institutions. There exists a glaring disparity in residency exposure to Xiaflex®. Further research is warranted to elucidate how programs can provide residents with further exposure to the use of Xiaflex® in patients with Peyronie’s disease.

Published
2023
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36. A Prostate Imaging‐Reporting and Data System version 2.1‐based predictive model for clinically significant prostate cancer diagnosis.

Author

Gelikman, David G., Azar, William S., Yilmaz, Enis C., Lin, Yue, Shumaker, Luke A., Fang, Andrew M., Harmon, Stephanie A., Huang, Erich P., Parikh, Sahil H., Hyman, Jason A., Schuppe, Kyle, Nix, Jeffrey W., Galgano, Samuel J., Merino, Maria J., Choyke, Peter L., Gurram, Sandeep, Wood, Bradford J., Rais‐Bahrami, Soroush, Pinto, Peter A., and Turkbey, Baris

Subjects
*MAGNETIC resonance imaging, *RECEIVER operating characteristic curves, *CANCER diagnosis, *STATISTICAL models, *PROSTATE cancer
Abstract

Objectives Patients and Methods Results Conclusion To develop and validate a Prostate Imaging‐Reporting and Data System (PI‐RADS) version 2.1 (v2.1)‐based predictive model for diagnosis of clinically significant prostate cancer (csPCa), integrating clinical and multiparametric magnetic resonance imaging (mpMRI) data, and compare its performance with existing models.We retrospectively analysed data from patients who underwent prospective mpMRI assessment using the PI‐RADS v2.1 scoring system and biopsy at our institution between April 2019 and December 2023. A ‘Clinical Baseline’ model using patient demographics and laboratory results and an ‘MRI Added’ model additionally incorporating PI‐RADS v2.1 scores and prostate volumes were created and validated on internal and external patients. Both models were compared against two previously published MRI‐based algorithms for csPCa using area under the receiver operating characteristic curve (AUC) and decision curve analysis.A total of 1319 patients across internal and external cohorts were included. Our ‘MRI Added’ model demonstrated significantly improved discriminative ability (AUCinternal 0.88, AUCexternal 0.79) compared to our ‘Clinical Baseline’ model (AUCinternal 0.75, AUCexternal 0.68) (P < 0.001). The ‘MRI Added’ model also showed higher net benefits across various clinical threshold probabilities and compared to a ‘biopsy all’ approach, it reduced unnecessary biopsies (defined as biopsies without Gleason Grade Group ≥2 csPCa) by 27% in the internal cohort and 10% in the external cohort at a risk threshold of 25%. However, there was no significant difference in predictive ability and reduction in unnecessary biopsies between our model and comparative ones developed for PI‐RADS v2 and v1.Our PI‐RADS v2.1‐based mpMRI model significantly enhances csPCa prediction, outperforming the traditional clinical model in accuracy and reduction of unnecessary biopsies. It proves promising across diverse patient populations, establishing an updated, integrated approach for detection and management of prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Reducing False-Positives Due to Urinary Stagnation in the Prostatic Urethra on 18 F-DCFPyL PSMA PET/CT With MRI.

Author

Gelikman DG, Mena E, Lindenberg L, Azar WS, Rathi N, Yilmaz EC, Harmon SA, Schuppe KC, Hsueh JY, Huth H, Wood BJ, Gurram S, Choyke PL, Pinto PA, and Turkbey B

Subjects
Humans, Male, False Positive Reactions, Aged, Middle Aged, Retrospective Studies, Lysine analogs & derivatives, Prostate diagnostic imaging, Urea analogs & derivatives, Urea pharmacokinetics, Glutamate Carboxypeptidase II, Prostatic Neoplasms diagnostic imaging, Antigens, Surface, Aged, 80 and over, Positron Emission Tomography Computed Tomography, Magnetic Resonance Imaging, Urethra diagnostic imaging
Abstract

Purpose: Prostate-specific membrane antigen (PSMA)-targeting PET radiotracers reveal physiologic uptake in the urinary system, potentially misrepresenting activity in the prostatic urethra as an intraprostatic lesion. This study examined the correlation between midline 18 F-DCFPyL activity in the prostate and hyperintensity on T2-weighted (T2W) MRI as an indication of retained urine in the prostatic urethra., Patients and Methods: Eighty-five patients who underwent both 18 F-DCFPyL PSMA PET/CT and prostate MRI between July 2017 and September 2023 were retrospectively analyzed for midline radiotracer activity and retained urine on postvoid T2W MRIs. Fisher's exact tests and unpaired t tests were used to compare residual urine presence and prostatic urethra measurements between patients with and without midline radiotracer activity. The influence of anatomical factors including prostate volume and urethral curvature on urinary stagnation was also explored., Results: Midline activity on PSMA PET imaging was seen in 14 patients included in the case group, whereas the remaining 71 with no midline activity constituted the control group. A total of 71.4% (10/14) and 29.6% (21/71) of patients in the case and control groups had urethral hyperintensity on T2W MRI, respectively ( P < 0.01). Patients in the case group had significantly larger mean urethral dimensions, larger prostate volumes, and higher incidence of severe urethral curvature compared with the controls., Conclusions: Stagnated urine within the prostatic urethra is a potential confounding factor on PSMA PET scans. Integrating PET imaging with T2W MRI can mitigate false-positive calls, especially as PSMA PET/CT continues to gain traction in diagnosing localized prostate cancer., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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