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1. NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2–related complications

Author

Bodansky, Aaron, Vazquez, Sara E, Chou, Janet, Novak, Tanya, Al-Musa, Amer, Young, Cameron, Newhams, Margaret, Kucukak, Suden, Zambrano, Laura D, Mitchell, Anthea, Wang, Chung-Yu, Moffitt, Kristin, Halasa, Natasha B, Loftis, Laura L, Schwartz, Stephanie P, Walker, Tracie C, Mack, Elizabeth H, Fitzgerald, Julie C, Gertz, Shira J, Rowan, Courtney M, Irby, Katherine, Sanders, Ronald C, Kong, Michele, Schuster, Jennifer E, Staat, Mary A, Zinter, Matt S, Cvijanovich, Natalie Z, Tarquinio, Keiko M, Coates, Bria M, Flori, Heidi R, Dahmer, Mary K, Crandall, Hillary, Cullimore, Melissa L, Levy, Emily R, Chatani, Brandon, Nofziger, Ryan, Investigators, Overcoming COVID-19 Network Study Group, Yates, Masson, Smith, Chelsea, Zinter, MattS, McLaughlin, Gwenn, Randolph, Adrienne G, Newhams, Margaret M, Moon, Hye Kyung, Kobayashi, Takuma, Melo, Jeni, Chen, Sabrina R, Behl, Supriya, Drapeau, Noelle M, McCulloh, Russell J, Nofziger, Ryan A, Staat, Mary Allen, Rohlfs, Chelsea C, Reed, Nelson, Geha, Raif S, DeRisi, Joseph, Campbell, Angela P, and Anderson, Mark

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Vaccine Related, Infectious Diseases, Rare Diseases, Pneumonia, Clinical Research, Prevention, Emerging Infectious Diseases, Biodefense, Pediatric, Genetics, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Adult, Humans, Child, Adolescent, SARS-CoV-2, COVID-19, Autoantibodies, NF-kappa B, Haploinsufficiency, Leukocytes, Mononuclear, Interferon Type I, NF-kappa B p52 Subunit, Anti-interferon autoantibody, MIS-C, NFKB2, inborn errors of immunity, Overcoming COVID-19 Network Study Group Investigators, Immunology, Allergy
Abstract

BackgroundAutoantibodies against type I IFNs occur in approximately 10% of adults with life-threatening coronavirus disease 2019 (COVID-19). The frequency of anti-IFN autoantibodies in children with severe sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is unknown.ObjectiveWe quantified anti-type I IFN autoantibodies in a multicenter cohort of children with severe COVID-19, multisystem inflammatory syndrome in children (MIS-C), and mild SARS-CoV-2 infections.MethodsCirculating anti-IFN-α2 antibodies were measured by a radioligand binding assay. Whole-exome sequencing, RNA sequencing, and functional studies of peripheral blood mononuclear cells were used to study any patients with levels of anti-IFN-α2 autoantibodies exceeding the assay's positive control.ResultsAmong 168 patients with severe COVID-19, 199 with MIS-C, and 45 with mild SARS-CoV-2 infections, only 1 had high levels of anti-IFN-α2 antibodies. Anti-IFN-α2 autoantibodies were not detected in patients treated with intravenous immunoglobulin before sample collection. Whole-exome sequencing identified a missense variant in the ankyrin domain of NFKB2, encoding the p100 subunit of nuclear factor kappa-light-chain enhancer of activated B cells, aka NF-κB, essential for noncanonical NF-κB signaling. The patient's peripheral blood mononuclear cells exhibited impaired cleavage of p100 characteristic of NFKB2 haploinsufficiency, an inborn error of immunity with a high prevalence of autoimmunity.ConclusionsHigh levels of anti-IFN-α2 autoantibodies in children and adolescents with MIS-C, severe COVID-19, and mild SARS-CoV-2 infections are rare but can occur in patients with inborn errors of immunity.

Published
2023

2. On-time childhood vaccination before and during the COVID-19 pandemic in seven communities: Findings from the New Vaccine Surveillance Network

Author

Hofstetter, Annika M., Klein, Eileen J., Strelitz, Bonnie, Selvarangan, Rangaraj, Schuster, Jennifer E., Boom, Julie A., Sahni, Leila C., Halasa, Natasha B., Stewart, Laura S., Staat, Mary Allen, Rohlfs, Chelsea, Szilagyi, Peter G., Weinberg, Geoffrey A., Williams, John V., Michaels, Marian G., Moline, Heidi, Mirza, Sara A., Harrison, Christopher J., and Englund, Janet A.

Published
2024
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3. Underutilization of Influenza Antiviral Treatment Among Children and Adolescents at Higher Risk for Influenza-Associated Complications--United States, 2023-2024

Author

Frutos, Aaron M., Ahmad, Haris M., Ujamaa, Dawud, O'Halloran, Alissa C., Englund, Janet A., Klein, Eileen J., Zerr, Danielle M., Crossland, Melanie, Staten, Holly, Boom, Julie A., Sahni, Leila C., Halasa, Natasha B., Stewart, Laura S., Hamdan, Olla, Stopczynski, Tess, Schaffner, William, Talbot, H. Keipp, Michaels, Marian G., Williams, John V., Sutton, Melissa, Hendrick, M. Andraya, Staat, Mary A., Schlaudecker, Elizabeth P., Tesini, Brenda L., Felsen, Christina B., Weinberg, Geoffrey A., Szilagyi, Peter G., Anderson, Bridget J., Rowlands, Jemma V., Khalifa, Murtada, Martinez, Marc, Selvarangan, Rangaraj, Schuster, Jennifer E., Lynfield, Ruth, McMahon, Melissa, Kim, Sue, Nunez, Val Tellez, Ryan, Patricia A., Monroe, Maya L., Wang, Yun F., Openo, Kyle P., Meek, James, Yousey-Hindes, Kimberly, Alden, Nisha B., Armistead, Isaac, Rao, Suchitra, Chai, Shua J., Kirley, Pam Daily, Toepfer, Ariana P., Dawood, Fatimah S., Moline, Heidi L., Uyeki, Timothy M., Ellington, Sascha, Garg, Shikha, Bozio, Catherine H., and Olson, Samantha M.

Subjects
Merck & Company Inc., Pfizer Inc., Vaccination, Influenza viruses, Influenza vaccines -- Complications and side effects, Influenza -- Complications and side effects -- Drug therapy, Hospital patients -- Drug therapy, Health
Abstract

Introduction Annually, seasonal influenza virus infections among children and adolescents in the United States are estimated to result in millions of medical visits, tens of thousands of hospitalizations, and hundreds [...]

Published
2024

4. Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.

Author

Tang, Juanjie, Novak, Tanya, Hecker, Julian, Grubbs, Gabrielle, Zahra, Fatema Tuz, Bellusci, Lorenza, Pourhashemi, Sara, Chou, Janet, Moffitt, Kristin, Halasa, Natasha B, Schwartz, Stephanie P, Walker, Tracie C, Tarquinio, Keiko M, Zinter, Matt S, Staat, Mary A, Gertz, Shira J, Cvijanovich, Natalie Z, Schuster, Jennifer E, Loftis, Laura L, Coates, Bria M, Mack, Elizabeth H, Irby, Katherine, Fitzgerald, Julie C, Rowan, Courtney M, Kong, Michele, Flori, Heidi R, Maddux, Aline B, Shein, Steven L, Crandall, Hillary, Hume, Janet R, Hobbs, Charlotte V, Tremoulet, Adriana H, Shimizu, Chisato, Burns, Jane C, Chen, Sabrina R, Moon, Hye Kyung, Lange, Christoph, Randolph, Adrienne G, and Khurana, Surender

Subjects
Good Health and Well Being
Published
2022

5. Humoral and cellular response to the COVID-19 vaccine in immunocompromised children

Author

Morgans, Heather A., Bradley, Todd, Flebbe-Rehwaldt, Linda, Selvarangan, Rangaraj, Bagherian, Amber, Barnes, Aliessa P., Bass, Julie, Cooper, Ashley M., Fischer, Ryan, Kleiboeker, Steve, Lee, Brian R., LeMaster, Cas, Markus, Kelsey, Morrison, Stephen, Myers, Angela, Myers, Doug, Payne, Erin, Schuster, Jennifer E., Standley, Sarah, Wieser, Andrea, and Warady, Bradley

Published
2023
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6. Immunophenotypic predictors of influenza vaccine immunogenicity in pediatric hematopoietic cell transplant recipients

Author

Naik, Swati, Williams, Christopher, Russo, Michael, Goyal, Rakesh, Blum, Samantha, Shoemaker, Lauren, Lacombe, Kirsten, Smith, Hannah, Allison, Kim J., Truong, Kenny, Dvorak, Christopher, Hamdan, Lubna, Batarseh, Einas, Haddadin, Zaid, Stewart, Laura S., Stahl, Anna, Potter, Molly, Rahman, Herdi, McHenry, Rendie, Bender, Margaret, Barto, Shari, Amarin, Justin Z., Dulek, Daniel E., Simmons, Joshua, Hayek, Haya, Chappell, James D., Nochowicz, Cindy Hager, Kitko, Carrie L., Schuster, Jennifer E., Muñoz, Flor M., Bocchini, Claire E., Moulton, Elizabeth A., Coffin, Susan E., Freedman, Jason L., Ardura, Monica I., Wattier, Rachel L., Maron, Gabriela, Grimley, Michael, Paulsen, Grant, Danziger-Isakov, Lara, Carpenter, Paul A., Englund, Janet A., Halasa, Natasha B., Spieker, Andrew J., and Kalams, Spyros A.

Published
2024
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7. Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C

Author

Tang, Juanjie, Novak, Tanya, Hecker, Julian, Grubbs, Gabrielle, Zahra, Fatema Tuz, Bellusci, Lorenza, Pourhashemi, Sara, Chou, Janet, Moffitt, Kristin, Halasa, Natasha B, Schwartz, Stephanie P, Walker, Tracie C, Tarquinio, Keiko M, Zinter, Matt S, Staat, Mary A, Gertz, Shira J, Cvijanovich, Natalie Z, Schuster, Jennifer E, Loftis, Laura L, Coates, Bria M, Mack, Elizabeth H, Irby, Katherine, Fitzgerald, Julie C, Rowan, Courtney M, Kong, Michele, Flori, Heidi R, Maddux, Aline B, Shein, Steven L, Crandall, Hillary, Hume, Janet R, Hobbs, Charlotte V, Tremoulet, Adriana H, Shimizu, Chisato, Burns, Jane C, Chen, Sabrina R, Moon, Hye Kyung, Lange, Christoph, Randolph, Adrienne G, and Khurana, Surender

Subjects
Pediatric, Pneumonia, Emerging Infectious Diseases, Infectious Diseases, Biodefense, Immunization, Prevention, Vaccine Related, Lung, Clinical Research, Good Health and Well Being, Adolescent, Antibodies, Viral, COVID-19, Child, Child, Preschool, Humans, Membrane Glycoproteins, Neutralization Tests, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Systemic Inflammatory Response Syndrome, Viral Envelope Proteins
Abstract

Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses (5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.

Published
2022

8. Characteristics and Clinical Outcomes of Vaccine-Eligible US Children Under-5 Years Hospitalized for Acute COVID-19 in a National Network

Author

Zambrano, Laura D., Newhams, Margaret M., Simeone, Regina M., Fleming-Dutra, Katherine E., Halasa, Natasha, Wu, Michael, Orzel-Lockwood, Amber O., Kamidani, Satoshi, Pannaraj, Pia S., Chiotos, Kathleen, Cameron, Melissa A., Maddux, Aline B., Schuster, Jennifer E., Crandall, Hillary, Kong, Michele, Nofziger, Ryan A., Staat, Mary A., Bhumbra, Samina S., Irby, Katherine, Boom, Julie A., Sahni, Leila C., Hume, Janet R., Gertz, Shira J., Maamari, Mia, Bowens, Cindy, Levy, Emily R., Bradford, Tamara T., Walker, Tracie C., Schwartz, Stephanie P., Mack, Elizabeth H., Guzman-Cottrill, Judith A., Hobbs, Charlotte V., Zinter, Matt S., Cvijanovich, Natalie Z., Bline, Katherine E., Hymes, Saul R., Campbell, Angela P., Randolph, Adrienne G., Murdock, Meghan, Kelley, Heather, Sanders, Ronald C., Miron, Laura, Barkely, Hannah, Jumarang, Jaycee, Hakimi, Daniel, Niell, Liria Muriscot, Baig, Natasha, Temte, Elizabeth, Thayer, Imogene, Petruccelli, Lexi, Zorensky, Frances, Sierra, Yamila, Gonzalez, Mark D., Ciric, Caroline R., Choi, Jong-Ha C., Baida, Nadine, Randolph, Adrienne G., Kucukak, Suden, Listerud, Eve, Clark, Maya, Dittrich, Rylie, Johnson, Brandi A., Drapeau, Noelle M., Martin, Lora, Malloch, Lacy, Martin, Maygan, Sanders, Cameron, Patterson, Kayla, Sullivan, Melissa, Pruitt, Shannon, Hymes, Saul, Harwayne-Gidansky, Ilana, Rohlfs, Chelsea C., Wolfe, Amber, Phengchomphet, Kathlyn, Bush, Jenny, Mohammed, Fatima A., Stewart, Laura S., Fernandez, Kailee, Abojaib, Leenah, Kyles, Molly J., and Campbell, Angela P.

Published
2023
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9. NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2–related complications

Author

Kong, Michele, Sanders, Ronald C., Jr., Yates, Masson, Smith, Chelsea, Cvijanovich, Natalie Z., Zinter, MattS., McLaughlin, Gwenn, Tarquinio, Keiko M., Coates, Bria M., Rowan, Courtney M., Randolph, Adrienne G., Newhams, Margaret M., Kucukak, Suden, Novak, Tanya, Moon, Hye Kyung, Kobayashi, Takuma, Melo, Jeni, Young, Cameron, Chen, Sabrina R., Chou, Janet, Flori, Heidi R., Dahmer, Mary K., Levy, Emily R., Behl, Supriya, Drapeau, Noelle M., Schuster, Jennifer E., Cullimore, Melissa L., McCulloh, Russell J., Gertz, Shira J., Schwartz, Stephanie P., Walker, Tracie C., Nofziger, Ryan A., Staat, Mary Allen, Rohlfs, Chelsea C., Fitzgerald, Julie C., Mack, Elizabeth H., Reed, Nelson, Halasa, Natasha B., Loftis, Laura L., Crandall, Hillary, Bodansky, Aaron, Vazquez, Sara E., Al-Musa, Amer, Newhams, Margaret, Zambrano, Laura D., Mitchell, Anthea, Wang, Chung-Yu, Moffitt, Kristin, Irby, Katherine, Staat, Mary A., Zinter, Matt S., Chatani, Brandon, Nofziger, Ryan, Geha, Raif S., DeRisi, Joseph, Campbell, Angela P., and Anderson, Mark

Published
2023
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11. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agarwal, Aastha, additional, Agwu, Allison L., additional, Albenberg, Lindsey, additional, Albert, Jonathan, additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernndez, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Appiah, Grace D., additional, Ardura, Monica I., additional, Arnon, Stephen S., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Ashkenazi-Hoffnung, Liat, additional, Asturias, Edwin J., additional, Aukstuolis, Kestutis, additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barnett, Elizabeth D., additional, Bechtel, Kirsten, additional, Benitz, William E., additional, Berkovich, Rachel, additional, Berman, David M., additional, Bialek, Stephanie R., additional, Bijker, Else M., additional, Bizzarro, Matthew J., additional, Bloch, Karen C., additional, Bocchini, Joseph A., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Brook, Itzhak, additional, Brown, Kevin Edward, additional, Bryant, Kristina P., additional, Camacho-Gonzalez, Andres F., additional, Caete-Gibas, Connie F., additional, Cantey, Joseph B., additional, Cantey, Paul, additional, Cardemil, Cristina V., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cataldi, Jessica R., additional, Chadwick, Ellen Gould, additional, Chancey, Rebecca J., additional, Cherry, Cara C., additional, Chiang, Silvia S., additional, Choi, Mary, additional, Christenson, John C., additional, Coffin, Susan E., additional, Cohn, Amanda, additional, Contopoulos-Ioannidis, Despina G., additional, Conway, James H., additional, Cortese, Margaret M., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Curtis, Donna, additional, Curtis, Nigel, additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, Teresa de la Morena, M., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Dodson, Daniel S., additional, Dolgner, Stephen J., additional, Dunn, Clinton, additional, Dyal, Jonathan, additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Enane, Leslie A., additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Fisher, Brian T., additional, Fisher, Randall G., additional, Flynn, Patricia Michele, additional, Foster, Monique A., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Gaensbauer, James, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gavigan, Patrick, additional, Gerber, Jeffrey S., additional, Gernez, Yael, additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Gould, Jane M., additional, Graziano, James, additional, Green, Amanda M., additional, Green, Michael, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Griffith, David C., additional, Gupta, Piyush, additional, Gutelius, Bruce J., additional, Gutman, Julie R., additional, Hall, Aron J., additional, Hamdy, Rana F., additional, Han, Jin-Young, additional, Handy, Lori K., additional, Hanisch, Benjamin, additional, Harper, Marvin B., additional, Harris, Aaron M., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Haston, Julia C., additional, Hawkes, Sarah.J., additional, Heald-Sargent, Taylor, additional, Hendley, J. Owen, additional, Hersh, Adam L., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Huang, Felicia Scaggs, additional, Hunstad, David A., additional, Hunt, W. Garrett, additional, Hwang, Loris Y., additional, Ilboudo, Christelle M., additional, Jaggi, Preeti, additional, Jean, Sophonie, additional, Jhaveri, Ravi, additional, Jirk-Pomajbkov, Kateina, additional, Kadry, Nadia A., additional, Kamb, Mary L., additional, Kapadia, Ronak K., additional, Katz, Ben Z., additional, Katz, Sophie E., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Khan, Muhammad Ali, additional, Khurana, Ananta, additional, Kimberlin, David W., additional, Klein, Bruce, additional, Kobayashi, Miwako, additional, Kociolek, Larry K., additional, Koh, Andrew Y., additional, Kotloff, Karen L., additional, Kroger, Andrew T., additional, Kronman, Matthew P., additional, Lalor, Leah, additional, Lauren, Christine T., additional, Leber, Amy, additional, Leshem, Eyal, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Lloyd, Kevin, additional, Loh, Katrina, additional, Long, Sarah S., additional, Lopman, Benjamin A., additional, Lucero, Yalda C., additional, Lugo, Debra J., additional, Lujn-Zilbermann, Jorge, additional, Maldonado, Yvonne A., additional, Manaloor, John J., additional, Manthiram, Kalpana, additional, Martin, Stacey W., additional, Mathew, Roshni, additional, Mazzulli, Tony, additional, McFarland, Elizabeth J., additional, McGann, Kathleen A., additional, McNamara, Lucy A., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejias, Asuncion, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammad Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Miller-Handley, Hilary, additional, Mintz, Eric, additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moorman, Anne C., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Muller, William J., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nayak, Jennifer Lynn, additional, Neely, Michael Noel, additional, Neil, Karen P., additional, Nelson, Christina A., additional, Nelson, Noele P., additional, Nichols, Megin, additional, Nicholson, William, additional, Nopper, Amy Jo, additional, Norton, Laura E., additional, Ochoa, Theresa J., additional, Olarte, Liset, additional, Onarecker, Timothy R., additional, Orenstein, Walter A., additional, ORyan, Miguel, additional, Otto, William R., additional, Ouellette, Christopher P., additional, Paddock, Christopher D., additional, Palazzi, Debra L., additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Paret, Michal, additional, Pastula, Daniel M., additional, Patterson, Thomas F., additional, Petersen, Brett W., additional, Petrosyan, Mikael, additional, Pickering, Larry K., additional, Pindyck, Talia, additional, Pinninti, Swetha, additional, Pittet, Laure F., additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prasanphanich, Nina Salinger, additional, Pritt, Bobbi S., additional, Prober, Charles G., additional, Puar, Neha, additional, Quilter, Laura A.S., additional, Ramilo, Octavio, additional, Rao, Suchitra, additional, Ratner, Adam J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Robinson, Candice L., additional, Romero, Jos R., additional, Rosen, David A., additional, Ross, Shannon A., additional, Rours, G. Ingrid J.G., additional, Rowe, Peter C., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Sacharok, Alexandra, additional, Sandora, Thomas J., additional, Sapp, Sarah G.H., additional, Sardana, Kabir, additional, Sauberan, Jason B., additional, Schaffzin, Joshua K., additional, Schillie, Sarah, additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa-Alvarez, Jose, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shaikh, Nader, additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Shope, Timothy R., additional, Dairiki Shortliffe, Linda M., additional, Shulman, Stanford T., additional, Shust, Gail F., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Upinder, additional, Smith, Christiana, additional, Smith, Lauren L., additional, Song, Eunkyung, additional, Souder, Emily, additional, Spearman, Paul, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Statler, Victoria A., additional, Steinbach, William J., additional, Stensvold, Christen Rune, additional, Stokes, Erin K., additional, Stoner, Bradley P., additional, Storch, Gregory A., additional, Straily, Anne, additional, Sullivan, Kathleen E., additional, Swanson, Douglas S., additional, Tanz, Robert R., additional, Taormina, Gillian, additional, Tate, Jacqueline E., additional, Taveras, Jeanette, additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomsen, Isaac, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tien, Vivian, additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dvke, Russell B., additional, Vaz, Louise Elaine, additional, Vijayan, Vini, additional, Vodzak, Jennifer, additional, Wagner, Thor A., additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wang, Huanyu, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Waters, Valerie, additional, Watson, Joshua R., additional, Weatherhead, Jill E., additional, Weinberg, Geoffrey A., additional, Weng, Mark K., additional, Wiederhold, Nathan P., additional, Wiesenfeld, Harold C., additional, Williams, Cydni, additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wittler, Robert R., additional, Wood, James B., additional, Woods, Charles Reece, additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Wu, Hsi-Yang, additional, Xu, Huan, additional, Yagupsky, Pablo, additional, Yi, Jumi, additional, Yoder, Jonathan, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, Zimmermann, Petra, additional, and Zong, Wenjing, additional

Published
2023
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12. The Modified Clinical Progression Scale for Pediatric Patients: Evaluation as a Severity Metric and Outcome Measure in Severe Acute Viral Respiratory Illness

Author

Leland, Shannon B., Staffa, Steven J., Newhams, Margaret M., Khemani, Robinder G., Marshall, John C., Young, Cameron C., Maddux, Aline B., Hall, Mark W., Weiss, Scott L., Schwarz, Adam J., Coates, Bria M., Sanders, Ronald C., Jr, Kong, Michele, Thomas, Neal J., Nofziger, Ryan A., Cullimore, Melissa L., Halasa, Natasha B., Loftis, Laura L., Cvijanovich, Natalie Z., Schuster, Jennifer E., Flori, Heidi, Gertz, Shira J., Hume, Janet R., Olson, Samantha M., Patel, Manish M., Zurakowski, David, and Randolph, Adrienne G.

Published
2023
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13. Association of Asthma With Treatments and Outcomes in Children With Critical Influenza

Author

Kong, Michele, Murdock, Meghan, Sanders, Ronald C., Jr., Irby, Katherine, Hefley, Glenda, Maddux, Aline B., Mourani, Peter M., Van, Kevin A., Mansour, Rachel, Miller, Kristen R., Grunwell, Jocelyn R., Coates, Bria M., Shukla, Avani, Chavez, Jairo, Randolph, Adrienne G., Newhams, Margaret M., Chen, Sabrina R., Jung, Emily, Flori, Heidi R., Dahmer, Mary K., Jayachandran, Chaandini, Hume, Janet R., Goertzen, Lexie, Faanes, Brittany, Schuster, Jennifer E., Bledsoe, Megan C., Clark, Shannon E., Cullimore, Melissa L., Wellman, Rachel L., Gertz, Shira J., Nofziger, Ryan A., Twinem, Nicole, Shein, Steven L., Rasal, Rajashri, Hall, Mark W., Flowers, Maggie, Steele, Lisa, Weiss, Scott L., Bush, Jenny L., Burnett, Ryan H., Thomas, Neal J., Spear, Debra, Halasa, Natasha B., Stewart, Laura S., Lynch, Tricia L., Olson, Samantha M., Patel, Manish M., Miller, Kristen, Patel, Manish, Fitzpatrick, Anne M., and Phipatanakul, Wanda

Published
2023
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14. Early Estimate of Nirsevimab Effectiveness for Prevention of Respiratory Syncytial Virus-Associated Hospitalization Among Infants Entering Their First Respiratory Syncytial Virus Season--New Vaccine Surveillance Network, October 2023-February 2024

Author

Moline, Heidi L., Tannis, Ayzsa, Toepfer, Ariana P., Williams, John V., Boom, Julie A., Englund, Janet A., Halasa, Natasha B., Staat, Mary Allen, Weinberg, Geoffrey A., Selvarangan, Rangaraj, Michaels, Marian G., Sahni, Leila C., Klein, Eileen J., Stewart, Laura S., Schlaudecker, Elizabeth P., Szilagyi, Peter G., Schuster, Jennifer E., Goldstein, Leah, Musa, Samar, Piedra, Pedro A., Zerr, Danielle M., Betters, Kristina A., Rohlfs, Chelsea, Albertin, Christina, Banerjee, Dithi, McKeever, Erin R., Kalman, Casey, Clopper, Benjamin R., McMorrow, Meredith L., and Dawood, Fatimah S.

Subjects
Merck & Company Inc., Palivizumab, Vaccination, Diseases -- Pennsylvania -- United States -- Ohio -- Texas, Infants, Vaccines, Pharmaceutical industry, Health
Abstract

Introduction Respiratory syncytial virus (RSV) is the leading cause of hospitalization in U.S. infants, responsible for 50,000-80,000 hospitalizations annually in children aged Methods Data Collection and Inclusion Criteria The New [...]

Published
2024

16. Risk Factors for Multisystem Inflammatory Syndrome in Children: A Case-control Investigation

Author

Zambrano, Laura D., Wu, Michael J., Martin, Lora, Malloch, Lacy, Chen, Sabrina, Newhams, Margaret M., Kucukak, Suden, Son, Mary Beth, Sanders, Cameron, Patterson, Kayla, Halasa, Natasha, Fitzgerald, Julie C., Leroue, Matthew K., Hall, Mark, Irby, Katherine, Rowan, Courtney M., Wellnitz, Kari, Sahni, Leila C., Loftis, Laura, Bradford, Tamara T., Staat, Mary, Babbitt, Christopher, Carroll, Christopher L., Pannaraj, Pia S., Kong, Michele, Schuster, Jennifer E., Chou, Janet, Patel, Manish M., Randolph, Adrienne G., Campbell, Angela P., and Hobbs, Charlotte V.

Published
2023
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17. Respiratory Syncytial Virus-Associated Hospitalizations in Children <5 Years: 2016–2022

Author

McMorrow, Meredith L., primary, Moline, Heidi L., additional, Toepfer, Ariana P., additional, Halasa, Natasha B., additional, Schuster, Jennifer E., additional, Staat, Mary A., additional, Williams, John V., additional, Klein, Eileen J., additional, Weinberg, Geoffrey A., additional, Clopper, Benjamin R., additional, Boom, Julie A., additional, Stewart, Laura S., additional, Selvarangan, Rangaraj, additional, Schlaudecker, Elizabeth P., additional, Michaels, Marian G., additional, Englund, Janet A., additional, Albertin, Christina S., additional, Mahon, Barbara E., additional, Hall, Aron J., additional, Sahni, Leila C., additional, and Curns, Aaron T., additional

Published
2024
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18. Accuracy of Influenza ICD-10 Diagnosis Codes in Identifying Influenza Illness in Children

Author

Antoon, James W., primary, Stopczynski, Tess, additional, Amarin, Justin Z., additional, Stewart, Laura S., additional, Boom, Julie A., additional, Sahni, Leila C., additional, Michaels, Marian G., additional, Williams, John V., additional, Englund, Janet A., additional, Klein, Eileen J., additional, Staat, Mary A., additional, Schlaudecker, Elizabeth P., additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E., additional, Weinberg, Geoffrey A., additional, Szilagyi, Peter G., additional, Perez, Ariana, additional, Moline, Heidi L., additional, Spieker, Andrew J., additional, Grijalva, Carlos G., additional, Olson, Samantha M., additional, and Halasa, Natasha B., additional

Published
2024
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19. Approach for defining human adenovirus infection and disease for central review adjudication in clinical studies

Author

Fisher, Brian T., primary, Blumenstock, Jesse, additional, Boge, Craig L. K., additional, Shuster, Sydney, additional, Seif, Alix E., additional, Green, Michael, additional, Michaels, Marian G., additional, Alexander, Jessie L., additional, Ardura, Monica I., additional, Miller, Tamara P., additional, Hijano, Diego R., additional, Muller, William J., additional, Schuster, Jennifer E., additional, Green, Abby M., additional, Dulek, Daniel E., additional, Kajon, Adriana E., additional, and Danziger‐Isakov, Lara, additional

Published
2024
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20. Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents

Author

Geva, Alon, Patel, Manish M., Newhams, Margaret M., Young, Cameron C., Son, Mary Beth F., Kong, Michele, Maddux, Aline B., Hall, Mark W., Riggs, Becky J., Singh, Aalok R., Giuliano, John S., Hobbs, Charlotte V., Loftis, Laura L., McLaughlin, Gwenn E., Schwartz, Stephanie P., Schuster, Jennifer E., Babbitt, Christopher J., Halasa, Natasha B., Gertz, Shira J., Doymaz, Sule, Hume, Janet R., Bradford, Tamara T., Irby, Katherine, Carroll, Christopher L., McGuire, John K., Tarquinio, Keiko M., Rowan, Courtney M., Mack, Elizabeth H., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Spinella, Philip C., Staat, Mary A., Clouser, Katharine N., Soma, Vijaya L., Dapul, Heda, Maamari, Mia, Bowens, Cindy, Havlin, Kevin M., Mourani, Peter M., Heidemann, Sabrina M., Horwitz, Steven M., Feldstein, Leora R., Tenforde, Mark W., Newburger, Jane W., Mandl, Kenneth D., and Randolph, Adrienne G.

Published
2021
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21. Maternal Vaccination and Risk of Hospitalization for Covid-19 Among Infants

Author

Halasa, Natasha B., Olson, Samantha M., Staat, Mary A., Newhams, Margaret M., Price, Ashley M., Pannaraj, Pia S., Boom, Julie A., Sahni, Leila C., Chiotos, Kathleen, Cameron, Melissa A., Bline, Katherine E., Hobbs, Charlotte V., Maddux, Aline B., Coates, Bria M., Michelson, Kelly N., Heidemann, Sabrina M., Irby, Katherine, Nofziger, Ryan A., Mack, Elizabeth H., Smallcomb, Laura, Schwartz, Stephanie P., Walker, Tracie C., Gertz, Shira J., Schuster, Jennifer E., Kamidani, Satoshi, Tarquinio, Keiko M., Bhumbra, Samina S., Maamari, Mia, Hume, Janet R., Crandall, Hillary, Levy, Emily R., Zinter, Matt S., Bradford, Tamara T., Flori, Heidi R., Cullimore, Melissa L., Kong, Michele, Cvijanovich, Natalie Z., Gilboa, Suzanne M., Polen, Kara N., Campbell, Angela P., Randolph, Adrienne G., and Patel, Manish M.

Published
2023
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22. SARS-CoV-2 Epidemiology and COVID-19 mRNA Vaccine Effectiveness Among Infants and Children Aged 6 Months-4 Years--New Vaccine Surveillance Network, United States, July 2022-September 2023

Author

Tannis, Ayzsa, Englund, Janet A., Perez, Ariana, Harker, Elizabeth J., Staat, Mary Allen, Schlaudecker, Elizabeth P., Halasa, Natasha B., Stewart, Laura S., Williams, John V., Michaels, Marian G., Selvarangan, Rangaraj, Schuster, Jennifer E., Sahni, Leila C., Boom, Julie A., Weinberg, Geoffrey A., Szilagyi, Peter G., Clopper, Benjamin R., Zhou, Yingtao, McMorrow, Meredith L., Klein, Eileen J., and Moline, Heidi L.

Subjects
United States. National Institutes of Health, Merck & Company Inc., Pfizer Inc., Vaccination, Medical research, Medicine, Experimental, Messenger RNA, Infection, Children -- Health aspects, Epidemiology, Vaccines, Disease susceptibility, Pharmaceutical industry, Health
Abstract

Introduction SARS-CoV-2 infection in young children and adolescents commonly manifests as a mild or asymptomatic illness; however, some children are at risk for severe disease, including those with certain chronic [...]

Published
2023

24. Pre-existing Immunocompromising Conditions and Outcomes of Acute COVID-19 Patients Admitted for Pediatric Intensive Care.

Author

Rowan, Courtney M, LaBere, Brenna, Young, Cameron C, Zambrano, Laura D, Newhams, Margaret M, Kucukak, Suden, McNamara, Elizabeth R, Mack, Elizabeth H, Fitzgerald, Julie C, Irby, Katherine, Maddux, Aline B, Schuster, Jennifer E, Kong, Michele, Dapul, Heda, Schwartz, Stephanie P, Bembea, Melania M, Loftis, Laura L, Kolmar, Amanda R, Babbitt, Christopher J, and Nofziger, Ryan A

Subjects
PUBLIC health surveillance, PRIMARY immunodeficiency diseases, LEUKOCYTE count, HEMATOLOGIC malignancies, TRANSPLANTATION of organs, tissues, etc., PLATELET count, CRITICALLY ill, PATIENTS, IMMUNOCOMPROMISED patients, HOSPITAL care, TREATMENT effectiveness, HOSPITALS, HOSPITAL mortality, AGE distribution, SEVERITY of illness index, PEDIATRICS, INTENSIVE care units, AUTOIMMUNE diseases, LENGTH of stay in hospitals, KIDNEY diseases, COVID-19, CRITICAL care medicine, COMORBIDITY, MIXED infections, EVALUATION, CHILDREN
Abstract

Background We aimed to determine if pre-existing immunocompromising conditions (ICCs) were associated with the presentation or outcome of patients with acute coronavirus disease 2019 (COVID-19) admitted for pediatric intensive care. Methods Fifty-five hospitals in 30 US states reported cases through the Overcoming COVID-19 public health surveillance registry. Patients <21 years admitted 12 March 2020–30 December 2021 to the pediatric intensive care unit (PICU) or high-acuity unit for acute COVID-19 were included. Results Of 1274 patients, 105 (8.2%) had an ICC, including 33 (31.4%) hematologic malignancies, 24 (22.9%) primary immunodeficiencies and disorders of hematopoietic cells, 19 (18.1%) nonmalignant organ failure with solid-organ transplantation, 16 (15.2%) solid tumors, and 13 (12.4%) autoimmune disorders. Patients with ICCs were older, had more underlying renal conditions, and had lower white blood cell and platelet counts than those without ICCs, but had similar clinical disease severity upon admission. In-hospital mortality from COVID-19 was higher (11.4% vs 4.6%, P =.005) and hospitalization was longer (P =.01) in patients with ICCs. New major morbidities upon discharge were not different between those with and without ICC (10.5% vs 13.9%, P =.40). In patients with ICCs, bacterial coinfection was more common in those with life-threatening COVID-19. Conclusions In this national case series of patients <21 years of age with acute COVID-19 admitted for intensive care, existence of a prior ICCs were associated with worse clinical outcomes. Reassuringly, most patients with ICCs hospitalized in the PICU for severe acute COVID-19 survived and were discharged home without new severe morbidities. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Respiratory Syncytial Virus-Associated Hospitalizations in Children <5 Years: 2016-2022.

Author

McMorrow, Meredith L., Moline, Heidi L., Toepfer, Ariana P., Halasa, Natasha B., Schuster, Jennifer E., Staat, Mary A., Williams, John V., Klein, Eileen J., Weinberg, Geoffrey A., Clopper, Benjamin R., Boom, Julie A., Stewart, Laura S., Selvarangan, Rangaraj, Schlaudecker, Elizabeth P., Michaels, Marian G., Englund, Janet A., Albertin, Christina S., Mahon, Barbara E., Hall, Aron J., and Sahni, Leila C.

Published
2024
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27. Reemergence of Mycoplasma pneumoniae Infections in Children and Adolescents After the COVID-19 Pandemic, United States, 2018-2024

Author

Edens, Chris, Clopper, Benjamin R., DeVies, Jourdan, Benitez, Alvaro, McKeever, Erin R., Johns, Dylan, Wolff, Bernard, Selvarangan, Rangaraj, Schuster, Jennifer E., Weinberg, Geoffrey A., Szilagyi, Peter G., Dawood, Fatimah S., Radhakrishnan, Lakshmi, Quigley, Christina, Sahni, Leila C., Halasa, Natasha, Stewart, Laura S., McMorrow, Meredith L., Whitaker, Brett, Zerr, Danielle M., Avadhanula, Vasanthi, Williams, John V., Michaels, Marian G., Kite-Powell, Aaron, Englund, Janet A., Staat, Mary Allen, Hartnett, Kathleen, Moline, Heidi L., Cohen, Adam L., and Diaz, Maureen

Subjects
Bacterial pneumonia -- Health aspects, Drug resistance in microorganisms -- Health aspects, Pneumonia -- Health aspects, Health
Abstract

Mycoplasma pneumoniae is a common cause of respiratory infections, particularly in school-aged children. Most infections display as a mild respiratory illness sometimes referred to as 'walking pneumonia.' However, some persons [...]

Published
2024

28. Understanding Variation in Rotavirus Vaccine Effectiveness Estimates in the United States: The Role of Rotavirus Activity and Diagnostic Misclassification

Author

Amin, Avnika B., Lash, Timothy L., Tate, Jacqueline E., Waller, Lance A., Wikswo, Mary E., Parashar, Umesh D., Stewart, Laura S., Chappell, James D., Halasa, Natasha B., Williams, John V., Michaels, Marian G., Hickey, Robert W., Klein, Eileen J., Englund, Janet A., Weinberg, Geoffrey A., Szilagyi, Peter G., Staat, Mary Allen, McNeal, Monica M., Boom, Julie A., Sahni, Leila C., Selvarangan, Rangaraj, Harrison, Christopher J., Moffatt, Mary E., Schuster, Jennifer E., Pahud, Barbara A., Weddle, Gina M., Azimi, Parvin H., Johnston, Samantha H., Payne, Daniel C., Bowen, Michael D., and Lopman, Benjamin A.

Published
2022
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29. Notes from the Field: Reemergence of Mycoplasma pneumoniae Infections in Children and Adolescents After the COVID-19 Pandemic, United States, 2018–2024

Author

Edens, Chris, primary, Clopper, Benjamin R., additional, DeVies, Jourdan, additional, Benitez, Alvaro, additional, McKeever, Erin R., additional, Johns, Dylan, additional, Wolff, Bernard, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E., additional, Weinberg, Geoffrey A., additional, Szilagyi, Peter G., additional, Dawood, Fatimah S., additional, Radhakrishnan, Lakshmi, additional, Quigley, Christina, additional, Sahni, Leila C., additional, Halasa, Natasha, additional, Stewart, Laura S., additional, McMorrow, Meredith L., additional, Whitaker, Brett, additional, Zerr, Danielle M., additional, Avadhanula, Vasanthi, additional, Williams, John V., additional, Michaels, Marian G., additional, Kite-Powell, Aaron, additional, Englund, Janet A., additional, Staat, Mary Allen, additional, Hartnett, Kathleen, additional, Moline, Heidi L., additional, Cohen, Adam L., additional, and Diaz, Maureen, additional

Published
2024
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30. School-Based Surveillance of Mycoplasma pneumoniae Trends and Impact on School Attendance by Students and Staff Members -- Missouri, Fall 2024.

Author

Almendares, Olivia M., Fritschmann, Brittney, Selvarangan, Rangaraj, Lee, Brian R., Edens, Chris, Diaz, Maureen, Whitaker, Brett, Tilsworth, Shannon, Porter, Janelle, Sagar, Nibha, Schuster, Jennifer E., Goldman, Jennifer L., and Kirking, Hannah L.

Subjects
PNEUMONIA, SCHOOL attendance, ADULT respiratory distress syndrome, STUDENT health, DISEASE prevalence
Abstract

The article presents examines Mycoplasma pneumonia trends and its impact on school attendance among students and staff in Missouri during fall 2024. Topics include school-based acute respiratory illness surveillance methods, findings on infection prevalence and symptoms, and implications for prevention and clinical management in educational settings.

Published
2024

31. Influenza C virus in U.S. children with acute respiratory infection 2016–2019

Author

Sederdahl, Bethany K., Weinberg, Geoffrey A., Campbell, Angela P., Selvarangan, Rangaraj, Schuster, Jennifer E., Lively, Joana Y., Olson, Samantha M., Boom, Julie A., Piedra, Pedro A., Halasa, Natasha B., Stewart, Laura, Szilagyi, Peter G., Balasubramani, G.K., Sax, Theresa, Martin, Judith M., Hickey, Robert W., Michaels, Marian G., and Williams, John V.

Published
2024
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33. Contributors

Author

Chang, Yeh-Chung, primary, Barbas, Andrew, additional, Dara, Jasmeen, additional, Dvorak, Christopher C., additional, Patel, Neil, additional, Green, Abby, additional, Madan, Rebecca Pellett, additional, Danziger-Isakov, Lara A., additional, Michaels, Marian G., additional, Green, Michael D., additional, Marón Alfaro, Gabriela M., additional, Gans, Hayley A., additional, Estabrook, Michele, additional, Ardura, Monica I., additional, Fisher, Brian T., additional, Sung, Lillian, additional, Posfay-Barbe, Klara M., additional, Halasa, Natasha, additional, Kelly, Matthew S., additional, Silverman, Michael A., additional, Wolf, Joshua, additional, Gerber, Jeffrey S., additional, Smith, Michael J., additional, Akinboyo, Ibukunoluwa C., additional, Nolt, Dawn, additional, Gonzalez, Blanca E., additional, Arshad, Mehreen, additional, Nowalk, Andrew, additional, Tamma, Pranita D., additional, Dulek, Daniel, additional, Statler, Victoria A., additional, Munoz, Flor M., additional, Lin, Philana Ling, additional, Sharma, Tanvi, additional, Gross, Thomas, additional, Allen, Upton D., additional, Muller, William J., additional, Herold, Betsy C., additional, Lugo, Debra J., additional, Zerr, Danielle M., additional, Waghmare, Alpana, additional, Englund, Janet A., additional, Florescu, Diana F., additional, Stohs, Erica J., additional, Laskin, Benjamin L., additional, Hirsch, Hans H., additional, Steinbach, William J., additional, Wattier, Rachel L., additional, Schuster, Jennifer E., additional, Lee, Philip, additional, Goldman, David L., additional, Christenson, John C., additional, Fox, Thomas G., additional, Chen, Sharon F., additional, Paulsen, Grant C., additional, Sue, Paul K., additional, Burton, Catherine, additional, Hanisch, Benjamin, additional, Gonzalez, Ivan A., additional, Stillwell, Terri, additional, Yildirim, Inci, additional, Doby Knackstedt, Elizabeth, additional, Mayer Arispe, Erick F., additional, and Shane, Andi L., additional

Published
2021
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35. Durability of Original Monovalent mRNA Vaccine Effectiveness Against COVID-19 Omicron–Associated Hospitalization in Children and Adolescents — United States, 2021–2023.

Author

Zambrano, Laura D., Newhams, Margaret M., Simeone, Regina M., Payne, Amanda B., Michael Wu, OrzelLockwood, Amber O., Halasa, Natasha B., Calixte, Jemima M., Pannaraj, Pia S., Mongkolrattanothai, Kanokporn, Boom, Julie A., Sahni, Leila C., Kamidani, Satoshi, Chiotos, Kathleen, Cameron, Melissa A., Maddux, Aline B., Irby, Katherine, Schuster, Jennifer E., Mack, Elizabeth H., and Biggs, Austin

Subjects
COVID-19 vaccines, HEALTH outcome assessment, VACCINE effectiveness, HOSPITAL care, VASOCONSTRICTORS
Abstract

Pediatric COVID-19 vaccination is effective in preventing COVID-19–related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021–October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19–related hospitalization and critical illness among U.S. children and adolescents aged 5–18 years, using a case-control design. Too few children and adolescents received bivalent or updated monovalent vaccines to separately evaluate their effectiveness. Most case-patients (persons with a positive SARS-CoV-2 test result) were unvaccinated, despite the high frequency of reported underlying conditions associated with severe COVID-19. VE of the original monovalent vaccine against COVID-19–related hospitalizations was 52% (95% CI = 33%–66%) when the most recent dose was administered <120 days before hospitalization and 19% (95% CI = 2%–32%) if the interval was 120–364 days. VE of the original monovalent vaccine against COVID-19–related hospitalization was 31% (95% CI = 18%–43%) if the last dose was received any time within the previous year. VE against critical COVID-19–related illness, defined as receipt of noninvasive or invasive mechanical ventilation, vasoactive infusions, extracorporeal membrane oxygenation, and illness resulting in death, was 57% (95% CI = 21%–76%) when the most recent dose was received <120 days before hospitalization, 25% (95% CI = –9% to 49%) if it was received 120–364 days before hospitalization, and 38% (95% CI = 15%–55%) if the last dose was received any time within the previous year. VE was similar after excluding children and adolescents with *These senior authors contributed equally to this report. documented immunocompromising conditions. Because of the low frequency of children who received updated COVID-19 vaccines and waning effectiveness of original monovalent doses, these data support CDC recommendations that all children and adolescents receive updated COVID-19 vaccines to protect against severe COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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36. 2644. Presence of Respiratory Viruses in the Upper Respiratory Tract of Febrile Infants ≤90 Days Old is Associated with Lower Prevalence of Invasive Bacterial Infection

Author

Nicholson, Erin G, primary, Stopczynski, Tess, additional, Sahni, Leila C, additional, Avadhanula, Vasanthi, additional, Piedra, Pedro A, additional, Amarin, Justin Z, additional, Chappell, James, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Williams, John V, additional, Michaels, Marian G, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Burkel, Veronica, additional, Moline, Heidi L, additional, Halasa, Natasha B, additional, and Boom, Julie A, additional

Published
2023
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37. 1755. Hospitalizations for Respiratory Viruses among Children 5–17 Years of Age in the Pre-COVID-19 Pandemic Era, the New Vaccine Surveillance Network, 2016–2020

Author

Sahni, Leila C, primary, Amarin, Justin Z, additional, Stopczynski, Tess, additional, Spieker, Andrew J, additional, Stewart, Laura S, additional, Staat, Mary A, additional, Quigley, Christina M, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Michaels, Marian G, additional, Williams, John V, additional, Szilagyi, Peter G, additional, Weinberg, Geoffrey A, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Clopper, Benjamin R, additional, Moline, Heidi L, additional, Avadhanula, Vasanthi, additional, Munoz, Flor M, additional, Piedra, Pedro A, additional, Halasa, Natasha B, additional, and Boom, Julie A, additional

Published
2023
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39. 1733. Effectiveness of Influenza Vaccination Against Influenza-Associated Emergency Department (ED) Visits and Hospitalizations Among Children With and Without Underlying Medical Conditions, New Vaccine Surveillance Network (NVSN), 2015-2016 through 2019-2020 Influenza Seasons

Author

Noble, Emma K, primary, Hayek, Haya, additional, Stewart, Laura S, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Michaels, Marian G, additional, Williams, John V, additional, Englund, Janet A, additional, Klein, Eileen J, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Clopper, Benjamin R, additional, Moline, Heidi L, additional, Halasa, Natasha B, additional, and Olson, Samantha M, additional

Published
2023
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40. 1752. Seasonal Human Coronavirus in Pediatric Patients enrolled by the New Vaccine Surveillance Network, 2016-2020

Author

Musa, Samar, primary, Zhang, Xueyan, additional, Balasubramani, G K, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Avadhanula, Vasanthi, additional, Piedra, Pedro A, additional, Quigley, Christina M, additional, Staat, Mary A, additional, Perez, Ariana, additional, Moline, Heidi L, additional, Williams, John V, additional, and Michaels, Marian G, additional

Published
2023
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42. 1104. Characteristics and Seasonality of Children Hospitalized with Parainfluenza Virus Infections (PIV), including PIV-4, New Vaccine Surveillance Network, 2016–2020

Author

de St. Maurice, Annabelle M, primary, Qwaider, Yasmeen Z, additional, Stopczynski, Tess, additional, Williams, John V, additional, Michaels, Marian G, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Spieker, Andrew J, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Selvarangan, Rangaraj, additional, Schuster, Jennifer E, additional, Zhou, Yingtao, additional, Moline, Heidi L, additional, Szilagyi, Peter G, additional, Halasa, Natasha B, additional, and Weinberg, Geoffrey A, additional

Published
2023
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43. 1101. Antiviral Prescription in Children with Influenza in Emergency Departments (ED): New Vaccine Surveillance Network (NVSN), 2016–2020

Author

Stopczynski, Tess, primary, Amarin, Justin Z, additional, Antoon, James W, additional, Hamdan, Olla, additional, Stewart, Laura S, additional, Chappell, James, additional, Spieker, Andrew J, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Hickey, Robert, additional, Michaels, Marian G, additional, Munoz, Flor M, additional, Boom, Julie A, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Campbell, Angela P, additional, Moline, Heidi L, additional, Burkel, Veronica, additional, Olson, Samantha M, additional, and Halasa, Natasha B, additional

Published
2023
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45. 905. Epidemiology of Enterovirus D68 in the US: New Vaccine Surveillance Network, 2017–2022

Author

Clopper, Benjamin R, primary, Moline, Heidi L, additional, Midgley, Claire, additional, Lopez, Adriana S, additional, Ng, Terry Fei Fan, additional, Perez, Ariana, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Sahni, Leila C, additional, Boom, Julie A, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Halasa, Natasha B, additional, Stewart, Laura S, additional, Hickey, Robert, additional, Michaels, Marian G, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Klein, Eileen J, additional, and Englund, Janet A, additional

Published
2023
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47. 2652. Detection of respiratory viruses by air sampling and student and staff surveillance testing in two elementary schools

Author

Gard, Luke C, primary, Goldman, Jennifer, additional, Selvarangan, Rangaraj, additional, Sasidharan, Anjana, additional, Banerjee, Dithi, additional, Hayes, Amanda M, additional, Petty, Sydnie, additional, Almendares, Olivia, additional, Sleweon, Sadia, additional, Kirking, Hannah L, additional, and Schuster, Jennifer E, additional

Published
2023
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48. 1742. Predictors of Antiviral Receipt for Influenza in Hospitalized U.S. Children, New Vaccine Surveillance Network (NVSN), 2016–2020

Author

Amarin, Justin Z, primary, Hamdan, Olla, additional, Antoon, James W, additional, Spieker, Andrew J, additional, Stewart, Laura S, additional, Michaels, Marian G, additional, Williams, John V, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Weinberg, Geoffrey A, additional, Szilagyi, Peter G, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Boom, Julie A, additional, Munoz, Flor M, additional, Staat, Mary A, additional, Schlaudecker, Elizabeth P, additional, Chappell, James, additional, Clopper, Benjamin R, additional, Moline, Heidi L, additional, Campbell, Angela P, additional, Olson, Samantha M, additional, and Halasa, Natasha B, additional

Published
2023
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49. 1754. Parainfluenza Virus Co-detection With Respiratory Syncytial Virus or Influenza is Associated with Higher Odds of Hospitalization in Children &lt; 2 Years Old, New Vaccine Surveillance Network (NVSN), 2016–2020

Author

Qwaider, Yasmeen Z, primary, De St. Maurice, Annabelle, additional, Amarin, Justin Z, additional, Stopczynski, Tess, additional, Spieker, Andrew J, additional, Stewart, Laura S, additional, Chappell, James, additional, Klein, Eileen J, additional, Englund, Janet A, additional, Williams, John V, additional, Michaels, Marian G, additional, Schlaudecker, Elizabeth P, additional, Staat, Mary A, additional, Piedra, Pedro A, additional, Avadhanula, Vasanthi, additional, Schuster, Jennifer E, additional, Selvarangan, Rangaraj, additional, Moline, Heidi L, additional, Halasa, Natasha B, additional, Perez, Ariana, additional, Szilagyi, Peter G, additional, and Weinberg, Geoffrey A, additional

Published
2023
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