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2. Minimum Orbital Periods of H-Rich Bodies

Author

Rappaport, S., Vanderburg, A., Schwab, J., and Nelson, L.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

In this work we derive the minimum allowed orbital periods of H-rich bodies ranging in mass from Saturn's mass to 1 $M_{\odot}$, emphasizing gas giants and brown dwarfs over the range $0.0003 - 0.074 \, M_\odot$. Analytic fitting formulae for $P_{\rm min}$ as a function of the mass of the body and as a function of the mean density are presented. We assume that the density of the host star is sufficiently high so as not to limit the minimum period. In many instances this implies that the host star is a white dwarf. This work is aimed, in part, toward distinguishing brown dwarfs from planets that are found transiting the host white dwarf without recourse to near infrared or radial velocity measurements. In particular, orbital periods of $\lesssim 100$ minutes are very likely to be brown dwarfs. The overall minimum period over this entire mass range is $\simeq 37$ minutes., Comment: 10 pages, 7 figures ApJ (accepted April 12, 2021)

Published
2021
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3. The ALF (Algorithms for Lattice Fermions) project release 2.4. Documentation for the auxiliary-field quantum Monte Carlo code

Author

ALF Collaboration, Assaad, F. F., Bercx, M., Goth, F., Götz, A., Hofmann, J. S., Huffman, E., Liu, Z., Toldin, F. Parisen, Portela, J. S. E., and Schwab, J.

Subjects
Condensed Matter - Strongly Correlated Electrons, High Energy Physics - Lattice, Physics - Computational Physics, Quantum Physics
Abstract

The Algorithms for Lattice Fermions package provides a general code for the finite-temperature and projective auxiliary-field quantum Monte Carlo algorithm. The code is engineered to be able to simulate any model that can be written in terms of sums of single-body operators, of squares of single-body operators and single-body operators coupled to a bosonic field with given dynamics. The package includes five pre-defined model classes: SU(N) Kondo, SU(N) Hubbard, SU(N) t-V and SU(N) models with long range Coulomb repulsion on honeycomb, square and N-leg lattices, as well as $Z_2$ unconstrained lattice gauge theories coupled to fermionic and $Z_2$ matter. An implementation of the stochastic Maximum Entropy method is also provided. One can download the code from our Git instance at https://git.physik.uni-wuerzburg.de/ALF/ALF/-/tree/ALF-2.4 and sign in to file issues., Comment: 126 pages, 12 figures. v7: update do ALF 2.4. Submission to SciPost. This article supersedes arXiv:1704.00131

Published
2020
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4. Metallic Plate-Lattice-Structures for a Modular and Lightweight Designed Die Casting Tool

Author

Winter, B., Schwab, J., Hürkamp, A., Müller, S., Dröder, K., Behrens, Bernd-Arno, Series Editor, Grzesik, Wit, Series Editor, Ihlenfeldt, Steffen, Series Editor, Kara, Sami, Series Editor, Ong, Soh-Khim, Series Editor, Tomiyama, Tetsuo, Series Editor, Williams, David, Series Editor, Liewald, Mathias, editor, Verl, Alexander, editor, Bauernhansl, Thomas, editor, and Möhring, Hans-Christian, editor

Published
2023
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5. Minimum Orbital Period of Pre-Cataclysmic Variables

Author

Nelson, L., Schwab, J., Ristic, M., and Rappaport, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

More than 20 pre-cataclysmic variable (pre-CV) systems have now been discovered with very short orbital periods ranging from 250 min down to 68 min. A pre-CV consists of a white dwarf or hot subdwarf primary and a low-mass companion star, where the companion star has successfully ejected the common envelope of the primary progenitor, but mass transfer from the companion star to the primary has not yet commenced. In this short-period range, a substantial fraction of the companion stars are likely to be either brown dwarfs with masses $\lesssim 0.07 \, M_\odot$ or stars at the bottom of the MS ($\lesssim 0.1 M_\odot$). The discovery of these short-period pre-CVs raises the question -- what is the shortest possible orbital period of such systems? We ran 500 brown dwarf/low-mass main sequence models with {\tt MESA} that cover the mass range from 0.002 to 0.1 $M_\odot$. We find the shortest possible orbital period is 40 min with a corresponding brown dwarf mass of 0.07 $M_\odot$ for an age equal to a Hubble time. We discuss the past evolution of these systems through the common envelope and suggest that many of the systems with present day white dwarf primaries may have exited the common envelope with the primary as a helium burning hot subdwarf. We also characterize the future evolution of the observed systems, which includes a phase as CVs below the conventional period minimum., Comment: 13 pages, 7 figures, submitted to ApJ (July 26, 2018), corresponding author email: lnelson@ubishops.ca

Published
2018
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6. A Search for a Surviving White Dwarf Companion in SN 1006

Author

Kerzendorf, W. E., Strampelli, G., Shen, K. J., Schwab, J., Pakmor, R., Do, T., Buchner, J., and Rest, A.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Multiple channels have been proposed to produce Type Ia supernovae, with many scenarios suggesting that the exploding white dwarf accretes from a binary companion pre-explosion. In almost all cases, theory suggests that this companion will survive. However, no such companion has been unambiguously identified in ancient supernova remnants -- possibly falsifying the accretion scenario. Existing surveys, however, have only looked for stars as faint as $\approx 0.1 L_\odot$ and thus would have missed a surviving white dwarf companion. In this work, we present very deep DECAM imaging $(u, g, r, z)$ of the Type Ia supernova remnant SN 1006 specifically to search for a potential surviving white dwarf companion. We find no object within the inner third of the SN 1006 remnant that is consistent with a relatively young cooling white dwarf. We find that if there is a companion white dwarf, it must have formed long ago and cooled undisturbed for $> 10^8$ yr to be consistent with the redder objects in our sample. We conclude that our findings are consistent with the complete destruction of the secondary (such as in a merger) or an unexpectedly cool and thus very dim surviving companion white dwarf., Comment: 9 pages, 5 figure, submitted to MNRAS - comments welcome

Published
2017
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8. Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Author

Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, Robba, Chiara, Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, and Robba, Chiara

Abstract

Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients.

Published
2024

9. Surgical outcomes of patients with diffuse-type tenosynovial giant-cell tumours: an international, retrospective, cohort study

Author

Fiocco, M., Dijkstra, P.D.S., Van der Wal, R.J.P., Daolio, P.A., Picci, P., Gronchi, A., Ferrari, S., Özger, H., Maki, R.G., Schreuder, H.W.B., Van der Geest, I.C.M., Bramer, J.A.M., Mastboom, W.J.B., Boffano, M., Goldenitsch, E., Campanacci, D., Cuomo, P., Ferguson, P.C., Griffin, A.M., Sun, Y., Schubert, T., Patel, K., Aranguren, M.S.J., Blancheton, A., Gouin, F., Dürr, H.R., Capellen, C.F., Schwab, J., Iwata, S., Vyrva, O., Weschenfelder, W., Wang, E.H.M., Wook Joo, M., Kang, Y.K., Chung, Y.G., Ebeid, W., Bruns, J., Ueda, T., Mastboom, Monique J L, Palmerini, Emanuela, Verspoor, Floortje G M, Rueten-Budde, Anja J, Stacchiotti, Silvia, Staals, Eric L, Schaap, Gerard R, Jutte, Paul C, Aston, Will, Gelderblom, Hans, Leithner, Andreas, Dammerer, Dietmar, Takeuchi, Akihiko, Thio, Quirina, Niu, Xiaohui, Wunder, Jay S, and van de Sande, Michiel A J

Published
2019
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11. The Dark-Matter Fraction in the Elliptical Galaxy Lensing the Quasar PG1115+080

Author

Pooley, D., Rappaport, S., Blackburne, J., Schechter, P. L., Schwab, J., and Wambsganss, J.

Subjects
Astrophysics
Abstract

We determine the most likely dark-matter fraction in the elliptical galaxy quadruply lensing the quasar PG1115+080 based on analyses of the X-ray fluxes of the individual images in 2000 and 2008. Between the two epochs, the A2 image of PG1115+080 brightened relative to the other images by a factor of six in X-rays. We argue that the A2 image had been highly demagnified in 2000 by stellar microlensing in the intervening galaxy and has recently crossed a caustic, thereby creating a new pair of micro-images and brightening in the process. Over the same period, the A2 image has brightened by a factor of only 1.2 in the optical. The most likely ratio of smooth material (dark matter) to clumpy material (stars) in the lensing galaxy to explain the observations is ~90% of the matter in a smooth dark-matter component and ~10% in stars., Comment: 7 pages, 9 figures, submitted to ApJ

Published
2008
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12. Chandra X-Ray Observation of the Globular Cluster GLIMPSE-C01

Author

Pooley, D., Rappaport, S., Levine, A., Pfahl, E., and Schwab, J.

Subjects
Astrophysics
Abstract

We have observed the recently discovered rich star cluster GLIMPSE-C01 for 46 ks with the Chandra X-ray Observatory. Seventeen X-ray sources with luminosities greater than 0.6e31 ergs/s were discovered, one of which is likely a quiescent low-mass X-ray binary. The spatial distribution of these X-ray sources with respect to the NIR and IR images of the cluster, combined with the luminosity and spectral hardness distributions of the sources, provide strong evidence that GLIMPSE-C01 is a rich Galactic globular cluster., Comment: 4 pages, submitted to ApJ Letters

Published
2007

13. Variational multichannel multiclass segmentation using unsupervised lifting with CNNs.

Author

Gruber, N., Schwab, J., Court, S., Gizewski, E., and Haltmeier, M.

Subjects
*CONVOLUTIONAL neural networks, *IMAGE segmentation, *FEATURE extraction
Abstract

We propose an unsupervised image segmentation approach, that combines a variational energy functional and deep con-volutional neural networks. The variational part is based on a recent multichannel multiphase Chan-Vese model, which is capable to extract useful information from multiple input images simultaneously. We implement a flexible multiclass segmentation method that divides a given image into K different regions. We use convolutional neural networks (CNNs) targeting a pre-decomposition of the image. By subsequently minimising the segmentation functional, the final segmentation is obtained in a fully unsupervised manner. Special emphasis is given to the extraction of informative feature maps serving as a starting point for the segmentation. The initial results indicate that the proposed method is able to decompose and segment the different regions of various types of images, such as texture and medical images and compare its performance with another multiphase segmentation method. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection)

Author

Anderson, Deverick J, Moehring, Rebekah W, Weber, David J, Lewis, Sarah S, Chen, Luke F, Schwab, J Conrad, Becherer, Paul, Blocker, Michael, Triplett, Patricia F, Knelson, Lauren P, Lokhnygina, Yuliya, Rutala, William A, and Sexton, Daniel J

Published
2018
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19. Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study

Author

Anderson, Deverick J, Chen, Luke F, Weber, David J, Moehring, Rebekah W, Lewis, Sarah S, Triplett, Patricia F, Blocker, Michael, Becherer, Paul, Schwab, J Conrad, Knelson, Lauren P, Lokhnygina, Yuliya, Rutala, William A, Kanamori, Hajime, Gergen, Maria F, and Sexton, Daniel J

Published
2017
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21. Grundlegende Strukturmerkmale eines kardiologischen Telemedizinzentrums für Patienten mit Herzinsuffizienz und implantierten Devices, Herzrhythmusstörungen und erhöhtem Risiko für den plötzlichen Herztod: Empfehlungen der Arbeitsgruppe 33 Telemonitoring in der Deutschen Gesellschaft für Kardiologie, Herz- und Kreislaufforschung e. V.

Author

Helms, T. M., Stockburger, M., Köhler, F., Leonhardt, V., Müller, A., Rybak, K., Sack, S., Schwab, J. O., Störk, S., Zippel-Schultz, B., and Perings, C. A.

Published
2019
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23. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.

Author

Cali, E., Suri, M., Scala, M., Ferla, M.P., Alavi, S., Faqeih, E.A., Bijlsma, E.K., Wigby, K.M., Baralle, D., Mehrjardi, M.Y.V., Schwab, J., Platzer, K., Steindl, K., Hashem, M., Jones, M., Niyazov, Dmitriy, Jacober, J., Littlejohn, R.O., Weis, D., Zadeh, N., Rodan, L., Goldenberg, A., Lecoquierre, F., Dutra-Clarke, M., Horvath, G., Young, D., Orenstein, N., Bawazeer, S., Vulto-van Silfhout, A.T., Herenger, Y., Dehghani, M., Seyedhassani, S.M., Bahreini, A., Nasab, M.E., Ercan-Sencicek, A.G., Firoozfar, Z., Movahedinia, M., Efthymiou, S., Striano, P., Karimiani, E.G., Salpietro, V., Taylor, J.C., Redman, M., Stegmann, A.P.A., Laner, A., Abdel-Salam, G., Li, M., Bengala, M., Müller, A.J., Digilio, M.C., Rauch, A., Gunel, M., Titheradge, H., Schweitzer, D.N., Kraus, A., Valenzuela, I., McLean, S.D., Phornphutkul, C., Salih, M., Begtrup, A., Schnur, R.E., Torti, E., Haack, T.B., Prada, C.E., Alkuraya, F.S., Houlden, H., Maroofian, R., Cali, E., Suri, M., Scala, M., Ferla, M.P., Alavi, S., Faqeih, E.A., Bijlsma, E.K., Wigby, K.M., Baralle, D., Mehrjardi, M.Y.V., Schwab, J., Platzer, K., Steindl, K., Hashem, M., Jones, M., Niyazov, Dmitriy, Jacober, J., Littlejohn, R.O., Weis, D., Zadeh, N., Rodan, L., Goldenberg, A., Lecoquierre, F., Dutra-Clarke, M., Horvath, G., Young, D., Orenstein, N., Bawazeer, S., Vulto-van Silfhout, A.T., Herenger, Y., Dehghani, M., Seyedhassani, S.M., Bahreini, A., Nasab, M.E., Ercan-Sencicek, A.G., Firoozfar, Z., Movahedinia, M., Efthymiou, S., Striano, P., Karimiani, E.G., Salpietro, V., Taylor, J.C., Redman, M., Stegmann, A.P.A., Laner, A., Abdel-Salam, G., Li, M., Bengala, M., Müller, A.J., Digilio, M.C., Rauch, A., Gunel, M., Titheradge, H., Schweitzer, D.N., Kraus, A., Valenzuela, I., McLean, S.D., Phornphutkul, C., Salih, M., Begtrup, A., Schnur, R.E., Torti, E., Haack, T.B., Prada, C.E., Alkuraya, F.S., Houlden, H., and Maroofian, R.

Abstract

01 januari 2023, Item does not contain fulltext, PURPOSE: Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyzes the methylation of arginine residues on several protein substrates. Biallelic pathogenic PRMT7 variants have previously been associated with a syndromic neurodevelopmental disorder characterized by short stature, brachydactyly, intellectual developmental disability, and seizures. To our knowledge, no comprehensive study describes the detailed clinical characteristics of this syndrome. Thus, we aim to delineate the phenotypic spectrum of PRMT7-related disorder. METHODS: We assembled a cohort of 51 affected individuals from 39 different families, gathering clinical information from 36 newly described affected individuals and reviewing data of 15 individuals from the literature. RESULTS: The main clinical characteristics of the PRMT7-related syndrome are short stature, mild to severe developmental delay/intellectual disability, hypotonia, brachydactyly, and distinct facial morphology, including bifrontal narrowing, prominent supraorbital ridges, sparse eyebrows, short nose with full/broad nasal tip, thin upper lip, full and everted lower lip, and a prominent or squared-off jaw. Additional variable findings include seizures, obesity, nonspecific magnetic resonance imaging abnormalities, eye abnormalities (i.e., strabismus or nystagmus), and hearing loss. CONCLUSION: This study further delineates and expands the molecular, phenotypic spectrum and natural history of PRMT7-related syndrome characterized by a neurodevelopmental disorder with skeletal, growth, and endocrine abnormalities.

Published
2023

24. Analysis of complications and revisions after spine surgery in 270 multiple myeloma patients with spinal involvement

Author

MS Orthopaedie Algemeen, Cancer, MS Radiotherapie, Regenerative Medicine and Stem Cells, Zijlstra, H, Pierik, R J, Crawford, A M, Tobert, D G, Wolterbeek, N, Oosterhoff, J H F, Delawi, D, Terpstra, W E, Kempen, D H R, Verlaan, J J, Schwab, J H, MS Orthopaedie Algemeen, Cancer, MS Radiotherapie, Regenerative Medicine and Stem Cells, Zijlstra, H, Pierik, R J, Crawford, A M, Tobert, D G, Wolterbeek, N, Oosterhoff, J H F, Delawi, D, Terpstra, W E, Kempen, D H R, Verlaan, J J, and Schwab, J H

Published
2023

25. Neurologic Outcomes After Radiation Therapy for Severe Spinal Cord Compression in Multiple Myeloma: A Study of 162 Patients

Author

Cancer, MS Orthopaedie Algemeen, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Zijlstra, H, Striano, B M, Crawford, A M, Groot, O Q, Raje, N, Tobert, D G, Patel, C G, Wolterbeek, N, Delawi, D, Kempen, D H R, Verlaan, J J, Schwab, J H, Cancer, MS Orthopaedie Algemeen, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Zijlstra, H, Striano, B M, Crawford, A M, Groot, O Q, Raje, N, Tobert, D G, Patel, C G, Wolterbeek, N, Delawi, D, Kempen, D H R, Verlaan, J J, and Schwab, J H

Published
2023

29. The Dramaturgy of Ophelia’s Bouquet

Author

Phillips, Chelsea, primary, Bradley, Kenzie Lynn, additional, Brown, Veshonte, additional, Davis, Luke, additional, Fischer, Kate, additional, Gonzalez, Alycia, additional, Bean Schwab, J., additional, Storey, Timothy, additional, and Stryker, Sarah, additional

Published
2023
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31. The Full Event Interpretation: An Exclusive Tagging Algorithm for the Belle II Experiment

Author

Keck, T., Abudinén, F., Bernlochner, Florian U., Cheaib, R., Cunliffe, S., Feindt, M., Ferber, T., Gelb, M., Gemmler, J., Goldenzweig, P., Heck, M., Hollitt, S., Kahn, J., Krohn, J.-F., Kuhr, T., Komarov, I., Ligioi, L., Lubej, M., Metzner, F., Prim, M., Pulvermacher, C., Ritter, M., Schwab, J., Sutcliffe, W., Tamponi, U., Tenchini, F., Toutounji, N. E., Urquijo, P., Weyland, D., and Zupanc, A.

Published
2019
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37. Neurologic Outcomes After Radiation Therapy for Severe Spinal Cord Compression in Multiple Myeloma: A Study of 162 Patients.

Author

Zijlstra, H., Striano, B. M., Crawford, A. M., Groot, O. Q., Raje, N., Tobert, D. G., Patel, C. G., Wolterbeek, N., Delawi, D., Kempen, D. H. R., Verlaan, J. J., and Schwab, J. H.

Abstract

Background: Bone destruction is the most frequent disease-defining clinical feature of multiple myeloma (MM), resulting in skeletal-related events such as back pain, pathological fractures, or neurologic compromise including epidural spinal cord compression (ESCC). Up to 24% of patients with MM will be affected by ESCC. Radiation therapy has been proven to be highly effective in pain relief in patients with MM. However, a critical knowledge gap remains with regard to neurologic outcomes in patients with high-grade ESCC treated with radiation. Methods: We retrospectively included 162 patients with MM and high-grade ESCC (grade 2 or 3) who underwent radiation therapy of the spine between January 2010 and July 2021. The primary outcome was the American Spinal Injury Association (ASIA) score after 12 to 24 months, or the last known ASIA score if the patient had had a repeat treatment or died. Multivariable logistic regression was used to assess factors associated with poor neurologic outcomes after radiation, defined as neurologic deterioration or lack of improvement. Results: After radiation therapy, 34 patients (21%) had no improvement in their impaired neurologic function and 27 (17%) deteriorated neurologically. Thirty-six patients (22%) underwent either surgery or repeat irradiation after the initial radiation therapy. There were 100 patients who were neurologically intact at baseline (ASIA score of E), of whom 16 (16%) had neurologic deterioration. Four variables were independently associated with poor neurologic outcomes: baseline ASIA (odds ratio [OR] = 6.50; 95% confidence interval [CI] = 2.70 to 17.38; p < 0.001), Eastern Cooperative Oncology Group (ECOG) performance status (OR = 6.19; 95% CI = 1.49 to 29.49; p = 0.015), number of levels affected by ESCC (OR = 4.02; 95% CI = 1.19 to 14.18; p = 0.026), and receiving steroids prior to radiation (OR = 4.42; 95% CI = 1.41 to 16.10; p = 0.015). Conclusions: Our study showed that 38% of patients deteriorated or did not improve neurologically after radiation therapy for high-grade ESCC. The results highlight the need for multidisciplinary input and efforts in the treatment of highgrade ESCC in patients with MM. Future studies will help to improve patient selection for specific and standardized treatments and to clearly delineate which patients are likely to benefit from radiation therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Therapy monitoring

Author

Kühne, I., Ceballos-Baumann, A. O., Conrad, B., Kruggel, F., von Einsiedel, H. Gräfin, Schneider, R., Kluge, R., Willmes, K., Stephan, K. M., Netz, J., Hömberg, V., Schönle, P. W., Schwall, D., Bischoff, C., Machetanz, J., Meyer, B.-U., Pallmann, F., Ohlmann, D., Krick, C., Jäger, H., Nachtigall, W., Schimrigk, K., Forster, J., Meyer, B. U., Bresser, B., Thomas, W., Schmitt, R. M., Mielke, U., Welsch, H. J., Lagler, E., Dillmann, U., Krämer, G., Lüder, G., Hopf, H. C., Haupt, W. F., Borberg, H., Rosenow, F., Stoll, M., Hamann, G., Donauer, E., Steudel, W. I., Elek, J. M., Orfgen, Th., Sieb, J. P., Dengler, R., Strittmatter, M., Holzer, G., Haaß, A., Rose, A., Westarp, M. E., Flügel, R. M., Bartmann, P., Fuchs, D., Hoff-Jörgensen, R., Clausen, D., Westarp, M. P., Kornhuber, H. H., Westphal, K. P., Bauer, J., Laupheimer, H., Hülser, P., Schreiber, H., Baumgärtner, K., Wollinsky, K. H., van Eick, H., Heidenreich, F., Leifeld, L., Benecke, R., Jost, Wolfgang H., Schimrigk, Klaus, Bergemann, N., Baas, H., Demisch, L., Fischer, P.-A., Alesch°, F., Fertl, E., Auff, E., Koos, W., Bauer, B., Schmidt, B., Grau, G., Henschel, S., Braus, Dieter F., Schwechheimer, Karl, Volk, Benedikt, Claus, D., Beck, E., Gmeiner, H. J., Puschmann, E., Brunhölzl, C., Jäger, W., Neundörfer, B., Seitz, R. J., Schlaug, G., Kleinschmidt, A., Reifenberger, G., Wechsler, W., Wirrwar, A., Nebeling, B., Treede, R.-D., Hansen, H. C., Kunze, K., Bufler, J., Toyka, K. V., Maelicke, A., Franke, Ch., Melms, A., Malcherek, G., Link, H., Kalbacher, H., Lindstrom, J., Oksenberg, J., Steinman, L., Müller, C., Platz, T., Denzler, P., Mauritz, K.-H., Binkofski, F., Kunesch, E., Kuhlmann, H., Hefter, H., Freund, H-J., Weindl, A., Boecker, H., Kuwert, T., Mayer, T., Winkler, B., Herzog, H., Feinendegen, L. E., Arnold, G., Eichhorn, T., Mai, N., Gasser, T., Marquard, C., Oertel, W. H., Werhahn, K. J., Fong, J., Rothwell, J. C., Shorvon, S., Thompson, P. D., Marsden, C. D., Elger, C. E., Hefner, G., Güldenberg, V., Meierkord, H., Lightman, St., Trimble, M., Jaspert, A., Spitzer, A., Grehl, H., Henningsen, H., Pause, M., Mundinger, F., Schwab, J., Günther, T., Kaendler, S. H., Enzensberger, W., Fischer, P-A., Raitzig, M., Müller, J., Zinner, J., Kasper, S., Stuerenburg, H. J., Hase, M., Hinse, P., Neunzig, P., Weis, M., Rechlin, T., Hilz, M. J., and Schimrigk, K.

Published
1992
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48. Clinical Experience

Author

Kiesewetter, H., Angelkort, B., Blume, J., Jung, F., Spitzer, S., Gerhards, M., Wenzel, E., Leipnitz, G., Bach, R., Birk, A., Schieffer, H., Böhme, H., Bulik, I., Erlenwein, S., Vogel, W., Dyckmans, J., Berg, G., Bette, L., Haass, A., Schwab, J., Heilmann, L., Wolf, S., Bertram, B., Reim, M., Wilhelm, H.-J., Hubertus, R., Simon, J., Tormann, T., Holbach, T., Koscielny, J., editor, Kiesewetter, H., editor, Jung, F., editor, and Haaß, A., editor

Published
1992
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50. Klinische Erfahrung

Author

Kiesewetter, H., Angelkort, B., Blume, J., Jung, F., Spitzer, S., Gerhards, M., Wenzel, E., Leipnitz, G., Bach, R., Birk, A., Schieffer, H., Böhme, H., Bulik, I., Erlenwein, S., Vogel, W., Dyckmans, J., Berg, G., Bette, L., Haaß, A., Schwab, J., Heilmann, L., Wolf, S., Bertram, B., Reim, M., Wilhelm, H.-J., Hubertus, R., Simon, J., Tormann, T., Holbach, T., Koscielny, J., editor, Kiesewetter, H., editor, Jung, F., editor, and Haaß, A., editor

Published
1991
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