Search

Your search keyword '"Schwabl, Philipp"' showing total 614 results
Start Over Author "Schwabl, Philipp"
614 results on '"Schwabl, Philipp"'

4. Von Willebrand factor processing in patients with advanced chronic liver disease and its relation to portal hypertension and clinical outcome

Author

Simbrunner, Benedikt, Villesen, Ida Falk, Scheiner, Bernhard, Paternostro, Rafael, Schwabl, Philipp, Stättermayer, Albert Friedrich, Marculescu, Rodrig, Pinter, Matthias, Quehenberger, Peter, Trauner, Michael, Karsdal, Morten, Lisman, Ton, Reiberger, Thomas, Leeming, Diana Julie, and Mandorfer, Mattias

Published
2023
Full Text
View/download PDF

5. Post-treatment LSM rather than change during treatment predicts decompensation in patients with cACLD after HCV cure

Author

Maria Agostini, Sofia, Balcar, Lorenz, Battistella, Sara, Chromy, David, Cornberg, Markus, Deterding, Katja, Fernandez, Inmaculada, Fernandez-Rodriguez, Conrado, Gea, Francisco, Koeck, Fiona, Krawanja, Julia, Neumayer, Daniela, Riado, Daniel, Rincón, Diego, Schwabl, Philipp, Simbrunner, Benedikt, Trauner, Michael, Uson, Clara, Wedemeyer, Heiner, Semmler, Georg, Alonso López, Sonia, Pons, Monica, Lens, Sabela, Dajti, Elton, Griemsmann, Marie, Zanetto, Alberto, Burghart, Lukas, Hametner-Schreil, Stefanie, Hartl, Lukas, Manzano, Marisa, Rodriguez-Tajes, Sergio, Zanaga, Paola, Schwarz, Michael, Gutierrez, María Luisa, Jachs, Mathias, Pocurull, Anna, Polo, Benjamín, Ecker, Dominik, Mateos, Beatriz, Izquierdo, Sonia, Real, Yolanda, Ahumada, Adriana, Bauer, David Josef Maria, Mauz, Jim Benjamin, Casanova-Cabral, Michelle, Gschwantler, Michael, Russo, Francesco Paolo, Azzaroli, Francesco, Maasoumy, Benjamin, Reiberger, Thomas, Forns, Xavier, Genesca, Joan, Bañares, Rafael, and Mandorfer, Mattias

Published
2024
Full Text
View/download PDF

7. Austrian consensus on the diagnosis and management of portal hypertension in advanced chronic liver disease (Billroth IV)

Author

Mandorfer, Mattias, Aigner, Elmar, Cejna, Manfred, Ferlitsch, Arnulf, Datz, Christian, Gräter, Tilmann, Graziadei, Ivo, Gschwantler, Michael, Hametner-Schreil, Stephanie, Hofer, Harald, Jachs, Mathias, Loizides, Alexander, Maieron, Andreas, Peck-Radosavljevic, Markus, Rainer, Florian, Scheiner, Bernhard, Semmler, Georg, Reider, Lukas, Reiter, Silvia, Schoder, Maria, Schöfl, Rainer, Schwabl, Philipp, Stadlbauer, Vanessa, Stauber, Rudolf, Tatscher, Elisabeth, Trauner, Michael, Ziachehabi, Alexander, Zoller, Heinz, Fickert, Peter, and Reiberger, Thomas

Published
2023
Full Text
View/download PDF

10. Genomics and spatial surveillance of Chagas disease and American visceral leishmaniasis

Author

Schwabl, Philipp

Subjects
616.9, Q Science (General), QR Microbiology
Abstract

The Trypanosomatidae are a family of parasitic protozoa that infect various animals and plants. Several species within the Trypanosoma and Leishmania genera also pose a major threat to human health. Among these are Trypanosoma cruzi and Leishmania infantum, aetiological agents of the highly debilitating and often deadly vector-borne zoonoses Chagas disease and American visceral leishmaniasis. Current treatment options are far from safe, only partially effective and rarely available in the impoverished regions of Latin America where these ‘neglected tropical diseases’ prevail. Wider-reaching, sustainable protection against T. cruzi and L. infantum might best be achieved by intercepting key routes of zoonotic transmission, but this prophylactic approach requires a better understanding of how these parasites disperse and evolve at various spatiotemporal scales. This dissertation addresses key questions around trypanosomatid parasite biology and spatial epidemiology based on high-resolution, geo-referenced DNA sequence datasets constructed from disease foci throughout Latin America: Which forms of genetic exchange occur in T. cruzi, and are exchange events frequent enough to significantly alter the distribution of important epidemiological traits? How do demographic histories, for example, the recent invasive expansion of L. infantum into the Americas, impact parasite population structure, and do structural changes pose a threat to public health? Can environmental variables predict parasite dispersal patterns at the landscape scale? Following the first chapter’s review of population genetic and genomic approaches in the study of trypanosomatid diseases in Latin America, Chapter 2 describes how reproductive polymorphism segregates T. cruzi populations in southern Ecuador. The study is the first to clearly demonstrate meiotic sex in this species, for decades thought to exchange genetic material only very rarely, and only by non-Mendelian means. T. cruzi subpopulations from the Ecuadorian study site exhibit all major hallmarks of sexual reproduction, including genome-wide Hardy-Weinberg allele frequencies, rapid decay of linkage disequilibrium with map distance and genealogies that fluctuate among chromosomes. The presence of sex promotes the transfer and transformation of genotypes underlying important epidemiological traits, posing great challenges to disease surveillance and the development of diagnostics and drugs. Chapter 3 demonstrates that mating events are also pivotal to L. infantum population structure in Brazil, where introduction bottlenecks have led to striking genetic discontinuities between sympatric strains. Genetic hybridization occurs genome-wide, including at a recently identified ‘miltefosine sensitivity locus’ that appears to be deleted from the majority of Brazilian L. infantum genomes. The study combines an array of genomic and phenotypic analyses to determine whether rapid population expansion or strong purifying selection has driven this prominent > 12 kb deletion to high abundance across Brazil. Results expose deletion size differences that covary with phylogenetic structure and suggest that deletion-carrying strains do not form a private monophyletic clade. These observations are inconsistent with the hypothesis that the deletion genotype rose to high prevalence simply as the result of a founder effect. Enzymatic assays show that loss of ecto-3’-nucleotidase gene function within the deleted locus is coupled to increased ecto-ATPase activity, raising the possibility that alternative metabolic strategies enhance L. infantum fitness in its introduced range. The study also uses demographic simulation modelling to determine whether L. infantum populations in the Americas have expanded from just one or multiple introduction events. Comparison of observed vs. simulated summary statistics using random forests suggests a single introduction from the Old World, but better spatial sampling coverage is required to rule out other demographic scenarios in a pattern-process modelling approach. Further sampling is also necessary to substantiate signs of convergent selection introduced above. Chapter 4 therefore develops a ‘genome-wide locus sequence typing’ (GLST) tool to summarize parasite genetic polymorphism at a fraction of genomic sequencing cost. Applied directly to the infection source (e.g., vector or host tissue), the method also avoids bias from cell purification and culturing steps typically involved prior to sequencing of trypanosomatid and other obligate parasite genomes. GLST scans genomic pilot data for hundreds of polymorphic sequence fragments whose thermodynamic properties permit simultaneous PCR amplification in a single reaction tube. For proof of principle, GLST is applied to metagenomic DNA extracts from various Chagas disease vector species collected in Colombia, Venezuela, and Ecuador. Epimastigote DNA from several T. cruzi reference clones is also analyzed. The method distinguishes 387 single-nucleotide polymorphisms (SNPs) in T. cruzi sub-lineage TcI and an additional 393 SNPs in non-TcI clones. Genetic distances calculated from these SNPs correlate with geographic distances among samples but also distinguish parasites from triatomines collected at common collection sites. The method thereby appears suitable for agent-based spatio-genetic (simulation) analyses left wanted by Chapter 3 – and further formulated in Chapter 5. The potential to survey parasite genetic diversity abundantly across landscapes compels deeper, more systematic exploration of how environmental variables influence the spread of disease. As environmental context is only marginally considered in the population genetic analyses of Chapters 2 – 4, Chapter 5 proposes a new, spatially explicit modelling framework to predict vector-borne parasite gene flow through heterogeneous environment. In this framework, remotely sensed environmental raster values are re-coded and merged into a composite ‘resistance surface’ that summarizes hypothesized effects of landscape features on parasite transmission among vectors and hosts. Parasite population genetic differentiation is then simulated on this surface and fitted to observed diversity patterns in order to evaluate original hypotheses on how environmental variables modulate parasite gene flow. The chapter thereby makes a maiden step from standard population genetic to ‘landscape genomic’ approaches in understanding the ecology and evolution of vector-borne disease. In summary, this dissertation first demonstrates the power of population genetics and genomics to understand fundamental biological properties of important protist parasites, then identifies areas where analytical tools are missing and creates new technical and conceptual frameworks to help fill these gaps. The general discussion (Chapter 6) also outlines several follow-up projects on the key finding of meiotic genetic signatures in T. cruzi. Exploiting recently developed T. cruzi genome-editing systems for the detection of meiotic gene expression and heterozygosis will help understand why and in which life cycle stage some parasite populations use sex and others do not. Long-read sequencing of parental and recombinant genomes will help understand the extent to which sex is diversifying T. cruzi phenotypes, especially virulence and drug resistance properties conferred by surface molecules with repetitive genetic bases intractable to short-read analysis. Chapter 6 also provides follow-up plans for all other research chapters. Emphasis is placed on advancing the complementarity, transferability and public health benefit of the many different methods and concepts employed in this work.

Published
2020
Full Text
View/download PDF

14. SAT-128 Circulating fibronectin levels are linked to endothelial dysfunction, fibrogenesis, and portal hypertension in advanced chronic liver disease

Author

Simbrunner, Benedikt, primary, Balcar, Lorenz, additional, Hammer, Fabian, additional, Hofer, Benedikt, additional, Semmler, Georg, additional, Jachs, Mathias, additional, Hartl, Lukas, additional, Dominik, Nina, additional, Schwabl, Philipp, additional, Marculescu, Rodrig, additional, Quehenberger, Peter, additional, Scheiner, Bernhard, additional, Trauner, Michael, additional, Mandorfer, Mattias, additional, and Reiberger, Thomas, additional

Published
2024
Full Text
View/download PDF

15. WED-089-YI Characterising the hemodynamic and pro-inflammatory profile of a CCl4/LPS-induced acute-on-chronic liver failure (ACLF) rat model

Author

Taru, Vlad, primary, Sorz-Nechay, Thomas, additional, Hofer, Benedikt, additional, Petrenko, Oleksandr, additional, Königshofer, Philipp, additional, Bonitz, Katharina, additional, Kramer, Georg, additional, Horstmeier, Henriette, additional, Regnat, Katharina, additional, Zinober, Kerstin, additional, Procopet, Bogdan, additional, Trauner, Michael, additional, Schwabl, Philipp, additional, Reiberger, Thomas, additional, and Simbrunner, Benedikt, additional

Published
2024
Full Text
View/download PDF

16. THU-540 Characterization of in vivo mouse models of regressive fibrosis and resolving portal hypertension

Author

Bonitz, Katharina, primary, Königshofer, Philipp, additional, Hofer, Benedikt, additional, Petrenko, Oleksander, additional, Sorz, Thomas, additional, Taru, Vlad, additional, Simbrunner, Benedikt, additional, Horstmeier, Henriette, additional, Zinober, Kerstin, additional, Regnat, Katharina, additional, Scharnagl, Hubert, additional, Trauner, Michael, additional, Gunther Kauschke, Stefan, additional, Pfisterer, Larissa, additional, Sun, Peng, additional, Truebenbach, Ines, additional, Schwabl, Philipp, additional, and Reiberger, Thomas, additional

Published
2024
Full Text
View/download PDF

17. THU-071 Impact of underlying portal hypertension and systemic inflammation on acute-on-chronic liver failure (ACLF) severity and outcome

Author

Taru, Vlad, primary, Kramer, Georg, additional, Balcar, Lorenz, additional, Hofer, Benedikt, additional, Schwarz, Michael, additional, Dominik, Nina, additional, Hartl, Lukas, additional, Jachs, Mathias, additional, Schneeweiss-Gleixner, Mathias, additional, Procopet, Bogdan, additional, Trauner, Michael, additional, Scheiner, Bernhard, additional, Schwabl, Philipp, additional, Mandorfer, Mattias, additional, Reiberger, Thomas, additional, and Simbrunner, Benedikt, additional

Published
2024
Full Text
View/download PDF

18. WED-125 Differential regulation of soluble guanylate cyclase signaling during liver fibrosis regression

Author

Sorz-Nechay, Thomas, primary, Brusilovskaya, Ksenia, additional, Königshofer, Philipp, additional, Hofer, Benedikt, additional, Petrenko, Oleksandr, additional, Simbrunner, Benedikt, additional, Taru, Vlad, additional, Zinober, Kerstin, additional, Regnat, Katharina, additional, Bonitz, Katharina, additional, Horstmeier, Henriette, additional, Truebenbach, Ines, additional, Sun, Peng, additional, Günther Kauschke, Stefan, additional, Pfisterer, Larissa, additional, Trauner, Michael, additional, Schwabl, Philipp, additional, and Reiberger, Thomas, additional

Published
2024
Full Text
View/download PDF

19. Non-invasive tests for clinically significant portal hypertension after HCV cure

Author

Semmler, Georg, Lens, Sabela, Meyer, Elias L., Baiges, Anna, Alvardo-Tapias, Edilmar, Llop, Elba, Tellez, Luis, Schwabl, Philipp, Mauro, Ezequiel, Escudé, Laia, Díez, Cristina, Ibañez-Samaniego, Luis, Puente, Ángela, Fortea, José Ignacio, Abadía, Marta, Zanetto, Alberto, Conthe, Andrés, Hernandez-Évole, Helena, Luzko Scheid, Irina Sofia, Jia, Jidong, Yoshiji, Hitoshi, Francque, Sven M., Tsochatzis, Emmanuel A., Russo, Francesco Paolo, Crespo, Gonzalo, Forns, Xavier, Bañares, Rafael, Villanueva, Càndid, Hernández-Gea, Virginia, Reiberger, Thomas, Bosch, Jaume, García Pagán, Juan Carlos, and Mandorfer, Mattias

Published
2022
Full Text
View/download PDF

24. Clinical Course of Porto-Sinusoidal Vascular Disease Is Distinct From Idiopathic Noncirrhotic Portal Hypertension

Author

Wöran, Katharina, Semmler, Georg, Jachs, Mathias, Simbrunner, Benedikt, Bauer, David Josef Maria, Binter, Teresa, Pomej, Katharina, Stättermayer, Albert Friedrich, Schwabl, Philipp, Bucsics, Theresa, Paternostro, Rafael, Lampichler, Katharina, Pinter, Matthias, Trauner, Michael, Mandorfer, Mattias, Stift, Judith, Reiberger, Thomas, and Scheiner, Bernhard

Published
2022
Full Text
View/download PDF

27. Subcutaneous Administration of a Monoclonal Antibody to Prevent Malaria

Author

Kayentao, Kassoum, primary, Ongoiba, Aissata, additional, Preston, Anne C., additional, Healy, Sara A., additional, Hu, Zonghui, additional, Skinner, Jeff, additional, Doumbo, Safiatou, additional, Wang, Jing, additional, Cisse, Hamidou, additional, Doumtabe, Didier, additional, Traore, Abdrahamane, additional, Traore, Hamadi, additional, Djiguiba, Adama, additional, Li, Shanping, additional, Peterson, Mary E., additional, Telscher, Shinyi, additional, Idris, Azza H., additional, Adams, William C., additional, McDermott, Adrian B., additional, Narpala, Sandeep, additional, Lin, Bob C., additional, Serebryannyy, Leonid, additional, Hickman, Somia P., additional, McDougal, Andrew J., additional, Vazquez, Sandra, additional, Reiber, Matthew, additional, Stein, Judy A., additional, Gall, Jason G., additional, Carlton, Kevin, additional, Schwabl, Philipp, additional, Traore, Siriman, additional, Keita, Mamadou, additional, Zéguimé, Amatigué, additional, Ouattara, Adama, additional, Doucoure, M’Bouye, additional, Dolo, Amagana, additional, Murphy, Sean C., additional, Neafsey, Daniel E., additional, Portugal, Silvia, additional, Djimdé, Abdoulaye, additional, Traore, Boubacar, additional, Seder, Robert A., additional, and Crompton, Peter D., additional

Published
2024
Full Text
View/download PDF

28. Contrasting genomic epidemiology between sympatricPlasmodium falciparumandPlasmodium vivaxpopulations

Author

Schwabl, Philipp, primary, Camponovo, Flavia, additional, Clementson, Collette, additional, Early, Angela M, additional, Laws, Margaret, additional, Forero-Peña, David A, additional, Noya, Oscar, additional, Grillet, María E, additional, Vanhove, Mathieu, additional, Anthony, Frank, additional, James, Kashana, additional, Singh, Narine, additional, Cox, Horace, additional, Niles-Robin, Reza, additional, Buckee, Caroline O, additional, and Neafsey, Daniel E, additional

Published
2024
Full Text
View/download PDF

29. The differential activation of cardiovascular hormones across distinct stages of portal hypertension predicts clinical outcomes

Author

Hartl, Lukas, Jachs, Mathias, Desbalmes, Christopher, Schaufler, Dunja, Simbrunner, Benedikt, Paternostro, Rafael, Schwabl, Philipp, Bauer, David Josef Maria, Semmler, Georg, Scheiner, Bernhard, Bucsics, Theresa, Eigenbauer, Ernst, Marculescu, Rodrig, Szekeres, Thomas, Peck-Radosavljevic, Markus, Kastl, Stefan, Trauner, Michael, Mandorfer, Mattias, and Reiberger, Thomas

Published
2021
Full Text
View/download PDF

30. Placental growth factor levels neither reflect severity of portal hypertension nor portal-hypertensive gastropathy in patients with advanced chronic liver disease

Author

Simbrunner, Benedikt, Stadlmann, Alexander, Schwabl, Philipp, Paternostro, Rafael, Bauer, David J.M., Bucsics, Theresa, Scheiner, Bernhard, Lampichler, Katharina, Wöran, Katharina, Beer, Andrea, Eigenbauer, Ernst, Pinter, Matthias, Stättermayer, Albert-Friedrich, Marculescu, Rodrig, Szekeres, Thomas, Trauner, Michael, Mandorfer, Mattias, and Reiberger, Thomas

Published
2021
Full Text
View/download PDF

33. Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana.

Author

Vanhove, Mathieu, Schwabl, Philipp, Clementson, Collette, Early, Angela M., Laws, Margaret, Anthony, Frank, Florimond, Célia, Mathieu, Luana, James, Kashana, Knox, Cheyenne, Singh, Narine, Buckee, Caroline O., Musset, Lise, Cox, Horace, Niles-Robin, Reza, and Neafsey, Daniel E.

Subjects
*PLASMODIUM, *PLASMODIUM falciparum, *WHOLE genome sequencing, *MOLECULAR cloning, *DRUG resistance, *INFECTIOUS disease transmission
Abstract

Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. In low transmission settings, parasites recombine with themselves, and the clonal lineage is propagated rather than broken up by outcrossing. We investigated whether stochastic/neutral factors drive the persistence and abundance of Plasmodium falciparum clonal lineages in Guyana, a country with relatively low malaria transmission, but the only setting in the Americas in which an important artemisinin resistance mutation (pfk13 C580Y) has been observed. We performed whole genome sequencing on 1,727 Plasmodium falciparum samples collected from infected patients across a five-year period (2016–2021). We characterized the relatedness between each pair of monoclonal infections (n = 1,409) through estimation of identity-by-descent (IBD) and also typed each sample for known or candidate drug resistance mutations. A total of 160 multi-isolate clones (mean IBD ≥ 0.90) were circulating in Guyana during the study period, comprising 13 highly related clusters (mean IBD ≥ 0.40). In the five-year study period, we observed a decrease in frequency of a mutation associated with artemisinin partner drug (piperaquine) resistance (pfcrt C350R) and limited co-occurence of pfcrt C350R with duplications of plasmepsin 2/3, an epistatic interaction associated with piperaquine resistance. We additionally observed 61 nonsynonymous substitutions that increased markedly in frequency over the study period as well as a novel pfk13 mutation (G718S). However, P. falciparum clonal dynamics in Guyana appear to be largely driven by stochastic factors, in contrast to other geographic regions, given that clones carrying drug resistance polymorphisms do not demonstrate enhanced persistence or higher abundance than clones carrying polymorphisms of comparable frequency that are unrelated to resistance. The use of multiple artemisinin combination therapies in Guyana may have contributed to the disappearance of the pfk13 C580Y mutation. Author summary: Malaria is caused by eukaryotic Plasmodium parasites, which undergo sexual recombination within mosquitoes. In settings with low transmission, such as Guyana, these parasites often recombine with themselves, leading to the propagation of identical clones. We explored the population genomics of Plasmodium falciparum malaria parasites in Guyana over five years to characterize clonal transmission dynamics and understand whether they were influenced by local drug resistance mutations under strong selection, including pfk13 C580Y, which confers resistance to artemisinin, and pfcrt C350R, which confers resistance to piperaquine. Based on whole genome sequencing results from 1,409 monoclonal (single-strain) samples, we identified 160 multi-isolate clones, in which all parasites share at least 90% of their genomes through recent common ancestry. We observed a decrease in frequency of the pfcrt C350R mutation, as well as the disappearance of pfk13 C580Y. Our findings contrast with the deterministic rise of drug resistance mutations observed in other geographic regions, sometimes associated with clonality. The simultaneous use of at least two different artemisinin combination therapies may have prevented the spread of an artemisinin-resistant clone in Guyana, suggesting a strategy for resistance management in other geographic regions. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Temporal and spatial dynamics of Plasmodium falciparum clonal lineages in Guyana

Author

Vanhove, Mathieu, primary, Schwabl, Philipp, additional, Clementson, Colette, additional, Early, Angela M, additional, Laws, Margaret, additional, Anthony, Frank, additional, Florimond, Célia, additional, Mathieu, Luana, additional, James, Kashana, additional, Knox, Cheyenne, additional, Singh, Narine, additional, Buckee, Caroline O., additional, Musset, Lise, additional, Niles-Robin, Reza, additional, Cox, Horace, additional, and Neafsey, Daniel E., additional

Published
2024
Full Text
View/download PDF

35. Decreased platelet activation predicts hepatic decompensation and mortality in patients with cirrhosis

Author

Hofer, Benedikt Silvester, primary, Brusilovskaya, Ksenia, additional, Simbrunner, Benedikt, additional, Balcar, Lorenz, additional, Eichelberger, Beate, additional, Lee, Silvia, additional, Hartl, Lukas, additional, Schwabl, Philipp, additional, Mandorfer, Mattias, additional, Panzer, Simon, additional, Reiberger, Thomas, additional, and Gremmel, Thomas, additional

Published
2023
Full Text
View/download PDF

38. Colonization and genetic diversification processes of Leishmania infantum in the Americas

Author

Schwabl, Philipp, Boité, Mariana C., Bussotti, Giovanni, Jacobs, Arne, Andersson, Bjorn, Moreira, Otacilio, Freitas-Mesquita, Anita L., Meyer-Fernandes, Jose Roberto, Telleria, Erich L., Traub-Csekö, Yara, Vaselek, Slavica, Leštinová, Tereza, Volf, Petr, Morgado, Fernanda N., Porrozzi, Renato, Llewellyn, Martin, Späth, Gerald F., and Cupolillo, Elisa

Published
2021
Full Text
View/download PDF

41. Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region

Author

Grillet, Maria E, Hernández-Villena, Juan V, Llewellyn, Martin S, Paniz-Mondolfi, Alberto E, Tami, Adriana, Vincenti-Gonzalez, Maria F, Marquez, Marilianna, Mogollon-Mendoza, Adriana C, Hernandez-Pereira, Carlos E, Plaza-Morr, Juan D, Blohm, Gabriella, Grijalva, Mario J, Costales, Jaime A, Ferguson, Heather M, Schwabl, Philipp, Hernandez-Castro, Luis E, Lamberton, Poppy H L, Streicker, Daniel G, Haydon, Daniel T, Miles, Michael A, Acosta-Serrano, Alvaro, Acquattela, Harry, Basañez, Maria G, Benaim, Gustavo, Colmenares, Luis A, Conn, Jan E, Espinoza, Raul, Freilij, Hector, Graterol-Gil, Mary C, Hotez, Peter J, Kato, Hirotomo, Lednicky, John A, Martinez, Clara E, Mas-Coma, Santiago, Morris, J Glen, Jr, Navarro, Juan C, Ramirez, Jose L, Rodriguez, Marlenes, Urbina, Julio A, Villegas, Leopoldo, Segovia, Maikell J, Carrasco, Hernan J, Crainey, James L, Luz, Sergio L B, Moreno, Juan D, Noya Gonzalez, Oscar O, Ramírez, Juan D, and Alarcón-de Noya, Belkisyolé

Published
2019
Full Text
View/download PDF

43. Resurgence of Vaccine-Preventable Diseases in Venezuela as a Regional Public Health Threat in the Americas

Author

Paniz-Mondolfi, Alberto E., Tami, Adriana, Grillet, Maria E., Marquez, Marilianna, Hernandez-Villena, Juan, Escalona- Rodriguez, Maria A., Blohm, Gabriela M., Mejias, Isis, Urbina-Medina, Huniades, Risquez, Alejandro, Castro, Julio, Carvajal, Ana, Walter, Carlos, Lopez, Maria G., Schwabl, Philipp, Hernandez-Castro, Luis, Miles, Michael A., Hotez, Peter J., Lednicky, John, Morris, J. Glenn, Jr., Crainey, James, Luz, Sergio, Ramirez, Juan D., Sordillo, Emilia, Llewellyn, Martin, Canache, Merari, Araque, Maria, and Oletta, Jose

Subjects
Measles -- Health aspects, Vaccines -- Health aspects, Disease transmission -- Health aspects, Public health -- Health aspects, Medical personnel, Scientists, Poliomyelitis, Diphtheria, Health, World Health Organization, Pan American Health Organization
Abstract

Residents of Venezuela are struggling to survive in a country with the world's highest annual inflation rate, 46,305% (1), and a minimum monthly wage of just USD $1.79 (5,196,000 Bolivars). [...]

Published
2019
Full Text
View/download PDF

45. Re-bleeding rates and survival after early transjugular intrahepatic portosystemic shunt (TIPS) in clinical practice

Author

Bucsics, Theresa, Schoder, Maria, Goeschl, Nicolas, Schwabl, Philipp, Mandorfer, Mattias, Diermayr, Magdalena, Feldner, Maria, Riedl, Florian, Bauer, David, Angermayr, Bernhard, Cejna, Manfred, Ferlitsch, Arnulf, Sieghart, Wolfgang, Trauner, Michael, Peck-Radosavljevic, Markus, Karner, Josef, Karnel, Franz, and Reiberger, Thomas

Published
2017
Full Text
View/download PDF

46. Diabetes impairs the haemodynamic response to non‐selective betablockers in compensated cirrhosis and predisposes to hepatic decompensation

Author

Paternostro, Rafael, primary, Jachs, Mathias, additional, Hartl, Lukas, additional, Simbrunner, Benedikt, additional, Scheiner, Bernhard, additional, Bauer, David, additional, Schwabl, Philipp, additional, Semmler, Georg, additional, Trauner, Michael, additional, Mandorfer, Mattias, additional, and Reiberger, Thomas, additional

Published
2023
Full Text
View/download PDF

47. Hepatic recompensation according to Baveno VII criteria is linked to a significant survival benefit in decompensated alcohol‐related cirrhosis

Author

Hofer, Benedikt Silvester, primary, Simbrunner, Benedikt, additional, Hartl, Lukas, additional, Jachs, Mathias, additional, Balcar, Lorenz, additional, Paternostro, Rafael, additional, Schwabl, Philipp, additional, Semmler, Georg, additional, Scheiner, Bernhard, additional, Trauner, Michael, additional, Mandorfer, Mattias, additional, and Reiberger, Thomas, additional

Published
2023
Full Text
View/download PDF

49. Clinical course of congestive hepatopathy pre/post heart transplantation

Author

Balcar, Lorenz, primary, Semmler, Georg, additional, Scheiner, Bernhard, additional, Stättermayer, Albert Friedrich, additional, Ćosić, Stefan, additional, Schwabl, Philipp, additional, Kazem, Niema, additional, Mandorfer, Mattias, additional, Hülsmann, Martin, additional, Zuckermann, Andreas, additional, and Reiberger, Thomas, additional

Published
2023
Full Text
View/download PDF

50. Systemic inflammation remains a critical determinant of the dynamic component of portal hypertension in abstinent patients with alcohol-related cirrhosis

Author

Hofer, Benedikt, primary, Simbrunner, Benedikt, additional, Zinober, Kerstin, additional, Semmler, Georg, additional, Königshofer, Philipp, additional, Sorz, Thomas, additional, Taru, Vlad, additional, Trauner, Michael, additional, Schwabl, Philipp, additional, Mandorfer, Mattias, additional, and Reiberger, Thomas, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results