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4. Zwerchfellparese

Author

Schwarz, Sarah Bettina, Kosse, Nils Jurriaan, Majorski, Daniel Sebastian, Windisch, Wolfram, Kreuter, Michael, editor, Costabel, Ulrich, editor, Herth, Felix JF, editor, and Kirsten, Detlef, editor

Published
2022
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10. Results of the Diaphragmatic Plication Database: 10 Years' Experience.

Author

Kosse, Nils Jurriaan, Galetin, Thomas, Schwarz, Sarah Bettina, Mathes, Tim, Koryllos, Aris, Lopez-Pastorini, Alberto, Beckers, Frank, and Stoelben, Erich

Subjects
FORCED expiratory volume, DATABASES, PULMONARY function tests, POSITIVE pressure ventilation, VITAL capacity (Respiration), LUNG volume measurements, SUPINE position
Abstract

Background Unilateral diaphragmatic paralysis or paresis (UDP) in adults is an often overlooked disease which relevantly impairs the patient's lung function and quality of life. Particularly in idiopathic UDP, there is no evidence for conservative therapy and only little evidence for surgical therapy. Methods The method involves retrospective single-center analysis of patients with UDP persistent for at least 1 year who were operated by diaphragmatic resection, plication, and augmentation with a polypropylene mesh. The patients were tested for lung and diaphragmatic function, six-minute walk test (6MWT), and blood gas analysis before, 3 and 12 months after surgery. Results In total, 85 patients received surgery for UDP. The most frequent reasons for UDP were idiopathic (67%), iatrogenic (mainly cardiac and cervical spine surgery; 24%), and trauma (9%). The mean operation time was 84 ± 24 minutes, the length of hospital stay 8.4 ± 3.9 days, chest tubes were removed after 11.7 ± 4.1 days. Overall morbidity was 42%, mortality 0%. Forced expiratory volume in one second (FEV1) in supine position improved by 12.4% absolute, vital capacity by 11.8% absolute, and sniff nasal inspiratory pressure by 1.4 kPa 12 months after surgery (p <0.001 each). Total lung capacity increased by 6.8% absolute at 12 months (p = 0.001) The 6MWT distance improved by 45.9 m at 3 months and 50.9 m at 12 months (p = 0.001, each). Conclusion Surgical therapy for UDP is highly effective in the long term. The superiority over conservative treatments needs to be evaluated prospectively with standardized physiotherapeutic protocols. FEV1 in supine position and 6MWT are easy to perform tests and represent statistically and patient-relevant outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Die Lunge im Fokus der Therapie

Author

Schumacher, Falk, Berger, Melanie, Wollsching-Strobel, Maximilian, Kroppen, Doreen, Schwarz, Sarah Bettina, Windisch, Wolfram, and Strunk, Johannes

Subjects
Medicine and health
Abstract

Vorgeschichte: Im November 2020 erfolgte die erstmalige Vorstellung einer 50-jährigen Patientin. Vorbekannt war ein effektiv therapierter Morbus Basedow und eine rezidivierende AV-Knoten-Reentry-Tachykardie (AVNRT) mit klinisch erfolgreicher Ablation. Die Patientin gab an nie geraucht zu haben. [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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13. Die Digitalisierung der Pneumologie und die Rolle der Fachgesellschaften

Author

Wollsching-Strobel, Maximilian, additional, Butt, Uta, additional, Majorski, Daniel Sebastian, additional, Mathes, Tim, additional, Stachwitz, Philipp, additional, Hagen, Julia, additional, Kroppen, Doreen, additional, Köhnlein, Thomas, additional, Windisch, Wolfram, additional, and Schwarz, Sarah Bettina, additional

Published
2022
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28. Additional file 1 of Living conditions and autonomy levels in COPD patients receiving non-invasive ventilation: impact on health related quality of life

Author

Schwarz, Sarah Bettina, Mathes, Tim, Majorski, Daniel Sebastian, Wollsching-Strobel, Maximilian, Kroppen, Doreen, Magnet, Friederike Sophie, and Windisch, Wolfram

Subjects
InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMilieux_COMPUTERSANDEDUCATION, Data_FILES, ComputerApplications_COMPUTERSINOTHERSYSTEMS
Abstract

Additional file 1. Supplementary Tables.

Published
2021
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29. Anemia Severely Reduces Health-Related Quality of Life in COPD Patients Receiving Long-Term Home Non-Invasive Ventilation

Author

Wollsching-Strobel,Maximilian, Schwarz,Sarah Bettina, Mathes,Tim, Majorski,Daniel Sebastian, Heidari,Pouya, Kroppen,Doreen, Magnet,Friederike Sophie, Windisch,Wolfram, Wollsching-Strobel,Maximilian, Schwarz,Sarah Bettina, Mathes,Tim, Majorski,Daniel Sebastian, Heidari,Pouya, Kroppen,Doreen, Magnet,Friederike Sophie, and Windisch,Wolfram

Abstract

Maximilian Wollsching-Strobel, Sarah Bettina Schwarz, Tim Mathes, Daniel Sebastian Majorski, Pouya Heidari, Doreen Kroppen, Friederike Sophie Magnet, Wolfram Windisch Cologne Merheim Hospital, Department of Pneumology, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne and Witten, North Rhine-Westphalia, GermanyCorrespondence: Wolfram WindischCologne Merheim Hospital, Department of Pneumology, Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Ostmerheimer Str. 200, Cologne and Witten, North Rhine-Westphalia, D-51109, GermanyTel +49 221 8907 18929Fax +49 221 8907 8305Email windischw@kliniken-koeln.dePurpose: To assess the influence of anemia on health-related quality of life (HRQL) in COPD patients receiving long-term non-invasive ventilation (NIV).Patients and Methods: In this prospective single-center cohort study, COPD patients on long-term NIV were analyzed between June 2015 and May 2020. Linear multiple regression analyses were performed using the results of the Severe Respiratory Insufficiency Questionnaire (SRI) along with the following variables: sex, age, body mass index, duration of NIV, exacerbation history (≤ 1 versus > 1 in the previous year), the updated Charlson comorbidity index, hemoglobin levels and anemia (WHO criteria).Results: Anemia was identified in 32.8% (N=128). Anemia (mean difference − 8.4, 95% CI − 2.0/-14.9 SRI points, P=0.011) and exacerbations (mean difference − 9.9, 95% CI − 4.3/-15.5 SRI points, P=0.001) each had a negative impact on SRI summary scores. Exacerbations were negatively associated with six out of seven SRI subscale scores, while anemia was negatively associated with four out of seven. SRI summary scores dropped by 1.5 points for every g/dl of hemoglobin (P=0.08). No other variables had an influence on the SRI scores.Conclusion: The present study has shown that within a cohort of COPD patients undergoing long

Published
2021

34. Sind ambulante Kontrollen einer außerklinischen nichtinvasiven Beatmung bei COPD Patienten möglich?

Author

Schwarz, Sarah Bettina, Callegari, Jens, Hamm, Christine, Windisch, Wolfram, and Magnet, Friederike Sophie

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Die aktualisierte Leitlinie zur außerklinischen Beatmung empfiehlt weiterhin die stationäre Verlaufskontrolle einer nichtinvasiven Beatmung (NIV), weist aber darauf hin, dass ambulante Versorgungsstrukturen zukünftig zu evaluieren sind. Dabei muss das Ziel einer modernen Versorgungsstruktur[zum vollständigen Text gelangen Sie über die oben angegebene URL], 26. Jahreskongress der Deutschen Interdisziplinären Gesellschaft für Außerklinische Beatmung (DIGAB) e.V.

Published
2018

35. Home noninvasive ventilatory support for patients with chronic obstructive pulmonary disease: patient selection and perspectives

Author

Storre,Jan Hendrik, Callegari,Jens, Magnet,Friederike Sophie, Schwarz,Sarah Bettina, Duiverman,Marieke Leontine, Wijkstra,Peter Jan, and Windisch,Wolfram

Subjects
International Journal of Chronic Obstructive Pulmonary Disease
Abstract

Jan Hendrik Storre,1,2 Jens Callegari,3 Friederike Sophie Magnet,3 Sarah Bettina Schwarz,3 Marieke Leontine Duiverman,4,5 Peter Jan Wijkstra,4,5 Wolfram Windisch3 1Department of Intensive Care, Sleep Medicine and Mechanical Ventilation, Asklepios Fachkliniken Munich-Gauting, Gauting, Germany; 2Department of Pneumology, University Medical Hospital, Freiburg, Germany; 3Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany; 4Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; 5Groningen Research Institute of Asthma and COPD (GRIAC), University of Groningen, Groningen, the Netherlands Abstract: Long-term or home mechanical noninvasive ventilation (Home-NIV) has become a well-established form of therapy over the last few decades for chronic hypercapnic COPD patients in European countries. However, meta-analyses and clinical guidelines do not recommend Home-NIV for COPD patients on a routine basis. In particular, there is ongoing debate about Home-NIV in chronic hypercapnic COPD regarding the overall effects, the most favorable treatment strategy, the selection of eligible patients, and the time point at which it is prescribed. The current review focuses on specific aspects of patient selection and discusses the various scientific as well as clinical-guided perspectives on Home-NIV in patients suffering from chronic hypercapnic COPD. In addition, special attention will be given to the topic of ventilator settings and interfaces. Keywords: exacerbation, pulmonary emphysema, hypercapnia, mechanical ventilation, respiratory insufficiency

Published
2018

37. Capillary PO2 does not adequately reflect arterial PO2 in hypoxemic COPD patients

Author

Magnet,Friederike Sophie, Majorski,Daniel, Sebastian, Callegari,Jens, Schwarz,Sarah Bettina, Schmoor,Claudia, Windisch,Wolfram, and Storre,Jan Hendrik

Subjects
respiratory system, International Journal of Chronic Obstructive Pulmonary Disease, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Friederike Sophie Magnet,1 Daniel Sebastian Majorski,1 Jens Callegari,1 Sarah Bettina Schwarz,1 Claudia Schmoor,2 Wolfram Windisch,1 Jan Hendrik Storre3,4 1Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH Witten/Herdecke University, Faculty of Health/School of Medicine, Cologne, Germany; 2Clinical Trials Unit, Medical Center– University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 3Department of Intensive Care, Sleep Medicine and Mechanical Ventilation, Asklepios Fachkliniken Munich-Gauting, Gauting, Germany; 4Department of Pneumology, University Medical Hospital, Freiburg, Germany Purpose: To compare arterial (PaO2) with capillary (PcO2) partial pressure of oxygen in hypoxemic COPD patients because capillary blood gas analysis (CBG) is increasingly being used as an alternative to arterial blood gas analysis (ABG) in a non-intensive care unit setting, although the agreement between PcO2 and PaO2 has not been evaluated in hypoxemic COPD patients.Patients and methods: Bland–Altman comparison of PaO2 and PcO2 served as the primary outcome parameter if PcO2 values were ≤60 mmHg and the secondary outcome parameter if PcO2 values were ≤55 mmHg. Pain associated with the measurements was assessed using a 100-mm visual analog scale.Results: One hundred and two PaO2/PcO2 measurement pairs were obtained. For PcO2 values ≤60 mmHg, the mean difference between PaO2 and PcO2 was 5.99±6.05 mmHg (limits of agreement: -5.88 to 17.85 mmHg). For PcO2 values ≤55 mmHg (n=73), the mean difference was 5.33±5.52 mmHg (limits of agreement: -5.48 to 16.15 mmHg). If PaO2 ≤55 (≤60) mmHg was set as the cut-off value, in 20.6% (30.4%) of all patients, long-term oxygen therapy have been unnecessarily prescribed if only PcO2 would have been assessed. ABG was rated as more painful compared with CBG.Conclusions: PcO2 does not adequately reflect PaO2 in hypoxemic COPD patients, which can lead to a relevant number of unnecessary long-term oxygen therapy prescriptions. Keywords: blood gas analysis, COPD, respiratory insufficiency, hypoxemia

Published
2017

48. Is Outpatient Control of Long-Term Non-Invasive Ventilation Feasible in Chronic Obstructive Pulmonary Disease Patients?

Author

Schwarz, Sarah Bettina, Callegari, Jens, Hamm, Christine, Windisch, Wolfram, and Magnet, Friederike Sophie

Subjects
*OBSTRUCTIVE lung disease treatment, *ARTIFICIAL respiration, *CARBON dioxide, *HOSPITAL care, *HOSPITAL wards, *HOSPITAL admission & discharge, *OUTPATIENT services in hospitals, *HOSPITAL respiratory services, *PATIENTS, *QUESTIONNAIRES, *PILOT projects, *RETROSPECTIVE studies, *SEVERITY of illness index, *TREATMENT duration, *PARTIAL pressure
Abstract

Background: Long-term non-invasive ventilation (NIV) is an established and increasingly used treatment option for patients with chronic hypercapnic chronic obstructive pulmonary disease (COPD). Following inpatient NIV establishment, inpatient control visits regularly occur thereafter. However, it remains unclear whether such control visits can also be performed in an outpatient setting, which, in turn, would reduce costs, patient burden and the complications related to hospitalization. Objectives: To investigate an outpatient setting with predefined criteria for hospitalization for patients with chronic hypercapnic COPD. Methods: An outpatient clinic located within the hospital in the vicinity of the respiratory care unit provided predefined criteria for hospitalization of COPD patients receiving long-term NIV therapy. The results of this setting were retrospectively analysed. Results: A total of 130 outpatient visits (80 patients) were analysed. In 93 cases (71.5%), hospital admission was not necessary, while hospitalization was performed in 37 cases (28.5%). Out of these, 7 cases with acute conditions required prompt hospitalization. Patients without hospitalization had better PaCO2 values (45.40 ± 5.27 vs. 50.05 ± 8.04, p = 0.002) and Severe Respiratory Insufficiency Questionnaire Summary scores (55.54 ± 19.74 vs. 41.82 ± 19.59, p = 0.012). Conclusion: Outpatient control of long-term NIV in a hospital setting is feasible and has the capacity to identify stable COPD patients in whom NIV therapy is sufficient according to predefined criteria. These patients may not require hospitalization and may account for more than two thirds of cases. [ABSTRACT FROM AUTHOR]

Published
2018
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