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16. Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. (Scientific Correspondence)

Author

Schwenn, O., Troost, R., Vogel, A., Grus, F., Beck, S., and Pfeiffer, N.

Subjects
Intraocular pressure -- Measurement, Glaucoma -- Care and treatment, Ocular manifestations of general diseases -- Care and treatment, Open-angle glaucoma -- Care and treatment, Health, Care and treatment, Measurement
Abstract

Background/aim: Intraocular pressure (IOP) is not a fixed constant value but rather has pulsatile components associated with cardiac action. The SmartLens dynamic observing tonometer (odc, Ophthalmic Development Company AG, Zurich, [...]

Published
2002

23. Bilateraler schleichender Sehverlust

Author

Al-Kamali, T and Schwenn, O

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Meningeome sind in der Regel langsam wachsende, gutartige Tumore, die von den Hirnhäuten ausgehen. Sie sind mit 14-20% aller primärer, intracranieller Tumoren häufige Entitäten, welche gewöhnlich im Subduralraum lokalisiert sind. Methode: Fallbericht: Eine[zum vollständigen Text gelangen Sie über die oben angegebene URL], 91. Versammlung des Vereins Rhein-Mainischer Augenärzte

Published
2018
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24. Pränatale Diagnosestellung von postsakkalen Tränenwegsstenosen

Author

von Goessel, A., Bahlmann, F., and Schwenn, O.

Abstract

Zusammenfassung: Wir berichten über 2 Fälle von postsakkalen Tränenwegsstenosen, die im Rahmen einer Schwangerschaftsvorsorgeunteruntersuchung intrauterin sonographisch festgestellt wurden. Die prä- und postpartalen Befunde werden demonstriert.

Published
2024
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26. Der akute Winkelblock, das akute Winkelblockglaukom

Author

Schwenn, O.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Definition: Die aktuelle Glaukomdefinition „progressive structural optic nerve damage“ ist völlig unabhängig vom Augeninnendruck und funktionellen Einschränkungen und stellt das Fortschreiten (Progression) des Krankheitsbildes und die strukturelle Sehnervenveränderung[zum vollständigen Text gelangen Sie über die oben angegebene URL], 90. Versammlung des Vereins Rhein-Mainischer Augenärzte

Published
2017

28. Filtrierende Glaukomoperationen – Trabekulektomie mit MMC

Author

Schwenn, O and Delvenakiotis, A

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Die Trabekulektomie mit Mitomycin C (MMC) ist bei konservativ nicht zu verhindernder Progression und drohender Einbuße an Lebensqualität bei Glaucoma chronicum simplex Therapie der ersten Wahl. Der langfristige Nutzen der intraoperativen Anwendung des Antimetaboliten MMC ist sicher belegt.[for full text, please go to the a.m. URL], 87. Versammlung des Vereins Rhein-Mainischer Augenärzte

Published
2014
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29. The European glaucoma prevention study design and baseline description of the participants

Author

Miglior, S, Zeyen, T, Pfeiffer, N, Cunha-Vaz, J, Linsen, M, Pellicci, L, Janssens, A, Van der Veken, A, Nerinckx, F, Boeyden, V, Detry-Morel, M, Kestelijn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Marini, S, Bagno, S, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Manni, G, Cocco, F, Glorialanza, G, Maria Villani, C, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Moura Pereira, J, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Pedro Silva, J, Romano, G, Silva, S, Adamsons, I, Caprioli, J, Torri, V, Poli, D, Nerviani, C, Tinazzi, A, Miglior S., Zeyen T., Pfeiffer N., Cunha-Vaz J., Linsen M. -C., Pellicci L., Janssens A., Van der Veken A., Nerinckx F., Boeyden V., Detry-Morel M., Kestelijn P., Van den Abeele K. V., Jacobs K., Decock C., Goethals M., Pourjavan S., Maris K., Kersten I., Vogel A., Herkel U., Schwenn O., Maser-Wahle M., Funk J., Schmidt B., Akbariyeh N., Burk R., Thomsen A., Grehn F., Marquardt D., Orzalesi N., Rossetti L., Ferrante M., Mandelli L., Marini S., Bagno S., Bertoni G., Blini M., De Molfetta M., Bonomi L., Morbio R., Marraffa M., Maraini G., Gandolfi S., Williams S., Cimino L., Dondi P., Lumbroso B., Manni G., Cocco F., Glorialanza G., Maria Villani C., Pocobelli A., Cesareo M., Cupo G., Neuschuler R., Pernini C., Catalani R., Ribeiro L., Faria I., Moura Pereira J., Chingui S., Duarte L., Carvalheira F., Baltar A., Simao A., Arede J., Magalhaes A., Abrantes P., Reina M., Pedro Silva J., Romano G., Silva S., Adamsons I., Caprioli J., Torri V., Poli D., Nerviani C., Tinazzi A., Miglior, S, Zeyen, T, Pfeiffer, N, Cunha-Vaz, J, Linsen, M, Pellicci, L, Janssens, A, Van der Veken, A, Nerinckx, F, Boeyden, V, Detry-Morel, M, Kestelijn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Marini, S, Bagno, S, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Manni, G, Cocco, F, Glorialanza, G, Maria Villani, C, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Moura Pereira, J, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Pedro Silva, J, Romano, G, Silva, S, Adamsons, I, Caprioli, J, Torri, V, Poli, D, Nerviani, C, Tinazzi, A, Miglior S., Zeyen T., Pfeiffer N., Cunha-Vaz J., Linsen M. -C., Pellicci L., Janssens A., Van der Veken A., Nerinckx F., Boeyden V., Detry-Morel M., Kestelijn P., Van den Abeele K. V., Jacobs K., Decock C., Goethals M., Pourjavan S., Maris K., Kersten I., Vogel A., Herkel U., Schwenn O., Maser-Wahle M., Funk J., Schmidt B., Akbariyeh N., Burk R., Thomsen A., Grehn F., Marquardt D., Orzalesi N., Rossetti L., Ferrante M., Mandelli L., Marini S., Bagno S., Bertoni G., Blini M., De Molfetta M., Bonomi L., Morbio R., Marraffa M., Maraini G., Gandolfi S., Williams S., Cimino L., Dondi P., Lumbroso B., Manni G., Cocco F., Glorialanza G., Maria Villani C., Pocobelli A., Cesareo M., Cupo G., Neuschuler R., Pernini C., Catalani R., Ribeiro L., Faria I., Moura Pereira J., Chingui S., Duarte L., Carvalheira F., Baltar A., Simao A., Arede J., Magalhaes A., Abrantes P., Reina M., Pedro Silva J., Romano G., Silva S., Adamsons I., Caprioli J., Torri V., Poli D., Nerviani C., and Tinazzi A.

Abstract

Objectives: The European Glaucoma Prevention Study seeks to evaluate the efficacy of reducing intraocular pressure (IOP), with dorzolamide to prevent or delay patients affected by ocular hypertension from developing primary open-angle glaucoma. Design: Randomized, double-blinded, controlled clinical trial. Participants: Patients (age ≥ 30 years) were enrolled from 18 European centers. The patients fulfilled a series of inclusion criteria including the measurements of IOP (22-29 mmHg), two normal and reliable visual fields (VFs) (on the basis of mean defect and corrected pattern standard deviation/corrected loss of variance of standard 30/11 Humphrey or Octopus perimetry), and normal optic disc as determined by the Optic Disc Reading Center (vertical and horizontal cup-to-disc ratios; asymmetry between the two eyes ≤ 0.4). Intervention: Patients were randomized to the treatment with dorzolamide or a placebo. Main Outcome Measures: End points are VF and/or optic disc changes. A VF change during the follow-up must be confirmed by two further positive tests. Optic disc change is defined by the agreement of two out of three independent observers evaluating optic disc stereo-slides. Results: One thousand seventy-seven subjects were randomized between January 1, 1997 and May 31, 1999. The mean age was 57.03 ± 10.3 years; 54.41% were women and 99.9% were Caucasian. Mean IOP was 23.6 ± 1.6 mmHg in both eyes. Mean visual acuity was 0.97 ± 0.11 in both eyes; mean refraction was 0.23 ± 1.76 diopters in the right eye and 0.18 ± 1.79 diopters in the left eye. Previous use of medication for ocular hypertension was reported by 38.4% of the patients, systemic hypertension by 28.1%, cardiovascular diseases by 12.9%, and diabetes mellitus by 4.7%. The qualifying VFs were normal and reliable according to protocol criteria. Conclusions: The mean IOP of the patients enrolled in the European Glaucoma Prevention Study is consistent with the estimated mean IOP (within the range of 22-29 mmH

Published
2002

31. Central corneal thickness in the European Glaucoma Prevention Study

Author

Pfeiffer, N, Torri, V, Miglior, S, Zeyen, T, Adamsons, I, Cunha-Vaz, J, Linsen, Mc, Pellicci, L, Janssens, A, van der Veken, A, Nerinckx, F, Boeyden, V, Kestelijn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Marini, G, Centofanti, M, Cocco, F, Glorialanza, G, Villani, Cm, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Pereira, Jm, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Silva, Jp, Romano, G, Silva, S, Floriani, I, Poli, D, Tinazzi, A, Caprioli, J, Wormald, R, Hejil, A, Airaksinen, J, Michaelis, J, Mandelli, La, Bagno, S, Shedden, A, Gottfried, E, Hutzelmann, J, Rusk, C, Reines, S, Spector, R, Hombrey, J, Snyder, H, Gacos, J, Snapinn, S, Getson, A, Amos, J, Serruys, K, Malbecq, W, John, E, Chapman, J, Beck, J, Tessi, C, Rao, N, Bottari, Fp, D'Achille, R, Wilkins, A, Magerl, K, Bauer, C, Derouwaux, C, Cunha, M, Santana, R, Andrade, Lg, Bule, S, Melo, R, Baumont, H, Bonaventura, I, Pfeiffer, N, Torri, V, Miglior, S, and The European Glaucoma Prevention Study, G

Subjects
Adult, Male, Intraocular pressure, medicine.medical_specialty, genetic structures, Settore MED/06 - Oncologia Medica, Glaucoma, ocular hypertension, central corneal thickness, Ocular hypertension, Glaucoma, Thiophenes, Placebo, law.invention, Cornea, Diabetes Complications, Sex Factors, Double-Blind Method, Randomized controlled trial, Dorzolamide, law, Diabetes mellitus, Ophthalmology, medicine, Humans, Intraocular Pressure, Aged, Ultrasonography, Sulfonamides, business.industry, Age Factors, Middle Aged, medicine.disease, eye diseases, Surgery, medicine.anatomical_structure, Female, Ocular Hypertension, sense organs, business, medicine.drug
Abstract

Purpose: To measure central corneal thickness (CCT) within the participants of the European Glaucoma Prevention Study (EGPS). This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma. Design: Randomized, double-masked, controlled, observational clinical trial. Participants: Eight hundred fifty-four of 1077 ocular hypertensive participants within the EGPS were investigated. Four hundred twenty-nine patients were treated with dorzolamide and 425 patients received placebo. Intervention: Treatment with dorzolamide or placebo (the vehicle of dorzolamide) in 1 or both eyes. Main Outcome Measures: Central corneal thickness as measured by ultrasound pachymetry (DGH-500 Pachette; DGH Technologies, Exton, PA). The CCT measurements were obtained in the morning before measuring IOP. Five measurements were taken from each eye of each patient within 5 minutes of application of anesthetic eye drops. Results: Mean CCT was 572.6±37.4 μm (range, 458.5-695.6 μm). The CCT was higher in younger patients, male patients, and diabetic patients. Mean CCTs for the 429 patients receiving dorzolamide were 574.2±38.48 μm (range, 458.5-695.6 μm) and 571.0±36.21 μm (469.7-690.1 μm) for the 425 patients receiving placebo (P = 0.205). Central corneal thickness did not correlate with refraction, baseline IOP, or systemic hypertension. Conclusion: Central corneal thickness measurements within the EGPS were greater than those reported in other studies of normal eyes without ocular hypertension. Larger CCT measurements correlated with male gender, younger age, and diabetes. © 2007 American Academy of Ophthalmology.

Published
2007

39. Reproducibility of evaluation of optic disc change for glaucoma with stereo optic disc photographs

Author

Miglior, S, Zeyen, T, Pfeiffer, N, Cunha-Vaz, J, Linsen, Mc, Pellicci, L, Janssens, A, van der Veken, A, Nerinckx, F, Boeyden, V, Czupper, M, Wendrix, G, Detry-Morel, M, Kestelyn, P, Van den Abeele, K, Jacobs, K, Decock, C, Goethals, M, Pourjavan, S, Maris, K, Deghislage, C, Kersten, I, Vogel, A, Herkel, U, Schwenn, O, Maser-Wahle, M, Funk, J, Schmidt, B, Akbariyeh, N, Burk, R, Thomsen, A, Grehn, F, Marquardt, D, Orzalesi, N, Rossetti, L, Ferrante, M, Mandelli, L, Marini, S, Bertoni, G, Blini, M, De Molfetta, M, Bonomi, L, Morbio, R, Marraffa, M, Maraini, G, Gandolfi, S, Williams, S, Cimino, L, Dondi, P, Lumbroso, B, Manni, G, Cocco, F, Glorialanza, G, Villani, Cm, Pocobelli, A, Cesareo, M, Cupo, G, Neuschuler, R, Pernini, C, Catalani, R, Ribeiro, L, Faria, I, Pereira, Jm, Chingui, S, Duarte, L, Carvalheira, F, Baltar, A, Simao, A, Arede, J, Magalhaes, A, Abrantes, P, Reina, M, Silva, Jp, Romano, G, Silva, S, Torri, V, Poli, D, Nerviani, C, Tinazzi, A, Floriani, I, Adamsons, I, Caprioli, J, Wormald, R, Heijl, A, Airaksinen, J, Michaelis, J, Shedden, A, Gottfried, E, Hutzelmann, J, Rusk, C, Reines, S, Spector, R, Hombrey, J, Snyder, H, Gacos, J, Snapinn, S, Getson, A, Amos, J, Serruys, K, Malbecq, W, John, E, Chapman, J, Beck, J, Tessi, C, Rao, N, Bottari, Fp, D'Achille, R, Wilkins, A, Bauer, C, Derouwaux, C, Van der Straeten, A, Cunha, M, Santana, R, Andrade, Lg, Bule, S, Melo, R, Baumont, H, and Bonaventura, I

Subjects
medicine.medical_specialty, genetic structures, Optic Disk, Optic disk, Glaucoma, Interobserver reproducibility, Cohen's kappa, Double-Blind Method, Ophthalmology, Optic Nerve Diseases, medicine, Photography, Humans, Observer Variation, Reproducibility, business.industry, Outcome measures, Reproducibility of Results, medicine.disease, eye diseases, Confidence interval, medicine.anatomical_structure, sense organs, business, Optic disc
Abstract

PURPOSE To determine the reproducibility of the assessment for glaucomatous change in serial optic disc stereo-slides. DESIGN Masked interobserver variability study. PARTICIPANTS Serial optic disc stereo-slides from 40 patients. METHODS Three independent ophthalmologists evaluated for change a set of two serial 20 degrees optic disc color stereo-slides of 40 patients. This test set was not from European Glaucoma Prevention Study (EGPS) patients. Each observer performed two evaluations at least 30 days apart and was masked from the temporal sequence of the slides and his or her previous evaluation. Each patient was graded as changed or stable by two-out-of-three agreement. A kappa statistic was used to calculate the intra- and interobserver reproducibility as well as the assignment reproducibility (first consensus versus second consensus). The same procedure was followed to test the reproducibility when another experienced ophthalmologist was added to one of the three reading centers. MAIN OUTCOME MEASURES Reproducibility in evaluating glaucomatous optic disc change. RESULTS The intraobserver reproducibility (95% confidence interval [CI]) in the evaluation of change ranged between 0.79 (0.45-1.14) and 1.00 (0.69-1.31). The interobserver reproducibility (95% CI) in the evaluation of change ranged between 0.45 (0.15-0.75) and 0.75 (0.44-1.06). The assignment reproducibility (first consensus versus second consensus in the evaluation of change) between the senior EGPS readers was 0.94 (0.63-1.25). The assignment reproducibility when another experienced ophthalmologist replaced one of the readers was 0.94 (0.63-1.25). CONCLUSIONS The assignment reproducibility of three expert readers looking for glaucomatous change in serial optic disc stereo-slides was excellent. It remained so when one of the three experts was replaced by another experienced reader.

Published
2003

42. Effect of head position on refraction in aphakic and phakic silicone-filled eyes

Author

Norbert Pfeiffer, Dick Hb, Schwenn O, Sima Pavlovic, and Jacobi Fk

Subjects
Male, medicine.medical_specialty, Supine position, Visual acuity, genetic structures, Pseudophakia, Posture, Visual Acuity, Aphakia, Postcataract, Refraction, Ocular, chemistry.chemical_compound, Silicone, Refractometer, Ophthalmology, Medicine, Humans, Silicone Oils, skin and connective tissue diseases, Dioptre, Lenses, Intraocular, business.industry, Retinal Detachment, General Medicine, Middle Aged, Refraction, eye diseases, Silicone oil, Refractometry, chemistry, Head position, Female, sense organs, medicine.symptom, business, Head
Abstract

BACKGROUND The refraction of the eye is altered significantly after the instillation of silicone oil into the vitreous cavity because of the silicone oil's high refractive index. The degree of the refractive change shows diurnal variation and depends on the patient's head position. PATIENTS AND METHODS To analyze the degree and time course of refractive changes with respect to head position, the authors performed objective refraction in five aphakic and five phakic silicone oil-instilled eyes with attached maculae using an automatic hand-held refractometer. In each patient, 25 measurements were taken at short intervals using a hand-held autorefractometer with the patient in different positions (supine, head tilted down, and primary eye position). RESULTS The highest shift of refraction was +5.95 +/- 2.63 diopters spherical equivalent in aphakic eyes and +2.45 +/- 0.71 diopters in the phakic eyes after the patient's position was changed from supine to head tilted down. Three minutes after the position change the refractive shift was stable in almost all eyes. Only slight changes in cylinder and the respective corresponding axis with a mean cylinder shift of 10.1 +/- 5.1 degrees were noted. CONCLUSIONS Immediately after the head position was changed, aphakic eyes demonstrated more pronounced refractive shifts than phakic eyes. The results of this study explain patients' reports of diurnal changes in visual acuity after intraocular silicone oil instillation. Refractive changes caused by silicone oil stabilized a few minutes after a change in head position.

Published
1997

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