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2. Successful weaning versus permanent cerebrospinal fluid diversion after aneurysmal subarachnoid hemorrhage: post hoc analysis of a Swiss multicenter study

Author

El-Garci, Ahmed, primary, Zindel-Geisseler, Olivia, additional, Dannecker, Noemi, additional, Rothacher, Yannick, additional, Schlosser, Ladina, additional, Zeitlberger, Anna, additional, Velz, Julia, additional, Sebök, Martina, additional, Eggenberger, Noemi, additional, May, Adrien, additional, Bijlenga, Philippe, additional, Guerra-Lopez, Ursula, additional, Maduri, Rodolfo, additional, Beaud, Valérie, additional, Starnoni, Daniele, additional, Chiappini, Alessio, additional, Rossi, Stefania, additional, Robert, Thomas, additional, Bonasia, Sara, additional, Goldberg, Johannes, additional, Fung, Christian, additional, Bervini, David, additional, Gutbrod, Klemens, additional, Maldaner, Nicolai, additional, Früh, Severin, additional, Schwind, Marc, additional, Bozinov, Oliver, additional, Neidert, Marian C., additional, Brugger, Peter, additional, Keller, Emanuela, additional, Germans, Menno R., additional, Regli, Luca, additional, Hostettler, Isabel C., additional, Stienen, Martin N., additional, _, _, additional, Krayenbühl, Niklaus, additional, Esposito, Giuseppe, additional, Moiraghi, Alessandro, additional, Rocca, Alda, additional, Seule, Martin A., additional, Weyerbrock, Astrid, additional, Hlavica, Martin, additional, and Mueller, Mandy, additional

Published
2023
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3. Successful weaning versus permanent cerebrospinal fluid diversion after aneurysmal subarachnoid hemorrhage: post hoc analysis of a Swiss multicenter study

Author

El-Garci, Ahmed, Zindel-Geisseler, Olivia, Dannecker, Noemi, Rothacher, Yannick, Schlosser, Ladina, Zeitlberger, Anna, Velz, Julia, Sebök, Martina, Eggenberger, Noemi, May, Adrien, Bijlenga, Philippe, Guerra-Lopez, Ursula, Maduri, Rodolfo, Beaud, Valérie, Starnoni, Daniele, Chiappini, Alessio, Rossi, Stefania, Robert, Thomas, Bonasia, Sara, Goldberg, Johannes, Fung, Christian, Bervini, David, Gutbrod, Klemens, Maldaner, Nicolai, Früh, Severin, Schwind, Marc, Bozinov, Oliver, Neidert, Marian C, Brugger, Peter, Keller, Emanuela, Germans, Menno R, Regli, Luca, Hostettler, Isabel C, and Stienen, Martin N

Subjects
610 Medicine & health
Abstract

OBJECTIVE Acute hydrocephalus is a frequent complication after aneurysmal subarachnoid hemorrhage (aSAH). Among patients needing CSF diversion, some cannot be weaned. Little is known about the comparative neurological, neuropsychological, and health-related quality-of-life (HRQOL) outcomes in patients with successful and unsuccessful CSF weaning. The authors aimed to assess outcomes of patients by comparing those with successful and unsuccessful CSF weaning; the latter was defined as occurring in patients with permanent CSF diversion at 3 months post-aSAH. METHODS The authors included prospectively recruited alert (i.e., Glasgow Coma Scale score 13-15) patients with aSAH in this retrospective study from six Swiss neurovascular centers. Patients underwent serial neurological (National Institutes of Health Stroke Scale), neuropsychological (Montreal Cognitive Assessment), disability (modified Rankin Scale), and HRQOL (EuroQol-5D) examinations at < 72 hours, 14-28 days, and 3 months post-aSAH. RESULTS Of 126 included patients, 54 (42.9%) developed acute hydrocephalus needing CSF diversion, of whom 37 (68.5%) could be successfully weaned and 17 (31.5%) required permanent CSF diversion. Patients with unsuccessful weaning were older (64.5 vs 50.8 years, p = 0.003) and had a higher rate of intraventricular hemorrhage (52.9% vs 24.3%, p = 0.04). Patients who succeed in restoration of physiological CSF dynamics improve on average by 2 points on the Montreal Cognitive Assessment between 48-72 hours and 14-28 days, whereas those in whom weaning fails worsen by 4 points (adjusted coefficient 6.80, 95% CI 1.57-12.04, p = 0.01). They show better neuropsychological recovery between 48-72 hours and 3 months, compared to patients in whom weaning fails (adjusted coefficient 7.60, 95% CI 3.09-12.11, p = 0.02). Patients who receive permanent CSF diversion (ventriculoperitoneal shunt) show significant neuropsychological improvement thereafter, catching up the delay in neuropsychological improvement between 14-28 days and 3 months post-aSAH. Neurological, disability, and HRQOL outcomes at 3 months were similar. CONCLUSIONS These results show a temporary but clinically meaningful cognitive benefit in the first weeks after aSAH in successfully weaned patients. The resolution of this difference over time may be due to the positive effects of permanent CSF diversion and underlines its importance. Patients who do not show progressive neuropsychological improvement after weaning should be considered for repeat CT imaging to rule out chronic (untreated) hydrocephalus.

Published
2023
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4. Longitudinal neuropsychological assessment after aneurysmal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia: a prospective Swiss multicenter study

Author

Stienen, Martin N., primary, Germans, Menno R., additional, Zindel-Geisseler, Olivia, additional, Dannecker, Noemi, additional, Rothacher, Yannick, additional, Schlosser, Ladina, additional, Velz, Julia, additional, Sebök, Martina, additional, Eggenberger, Noemi, additional, May, Adrien, additional, Haemmerli, Julien, additional, Bijlenga, Philippe, additional, Schaller, Karl, additional, Guerra-Lopez, Ursula, additional, Maduri, Rodolfo, additional, Beaud, Valérie, additional, Al-Taha, Khalid, additional, Daniel, Roy Thomas, additional, Chiappini, Alessio, additional, Rossi, Stefania, additional, Robert, Thomas, additional, Bonasia, Sara, additional, Goldberg, Johannes, additional, Fung, Christian, additional, Bervini, David, additional, Maradan-Gachet, Marie Elise, additional, Gutbrod, Klemens, additional, Maldaner, Nicolai, additional, Neidert, Marian C., additional, Früh, Severin, additional, Schwind, Marc, additional, Bozinov, Oliver, additional, Brugger, Peter, additional, Keller, Emanuela, additional, Marr, Angelina, additional, Roux, Sébastien, additional, Regli, Luca, additional, _, _, additional, Krayenbühl, Niklaus, additional, Esposito, Giuseppe, additional, Moiraghi, Alessandro, additional, Starnoni, Daniele, additional, Rocca, Alda, additional, Seule, Martin A., additional, Zeitlberger, Anna-Maria, additional, Weyerbrock, Astrid, additional, Hlavica, Martin, additional, and Müller, Mandy, additional

Published
2022
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5. Longitudinal neuropsychological assessment after aneurysmal subarachnoid hemorrhage and its relationship with delayed cerebral ischemia: a prospective Swiss multicenter study

Author

Stienen, Martin N, Germans, Menno R, Zindel-Geisseler, Olivia, Dannecker, Noemi, Rothacher, Yannick, Schlosser, Ladina, Velz, Julia, Sebök, Martina, Eggenberger, Noemi, May, Adrien, Haemmerli, Julien, Bijlenga, Philippe, Schaller, Karl, Guerra-Lopez, Ursula, Maduri, Rodolfo, Beaud, Valérie, Al-Taha, Khalid, Daniel, Roy Thomas, Chiappini, Alessio, Rossi, Stefania, Robert, Thomas, Bonasia, Sara, Goldberg, Johannes, Fung, Christian, Bervini, David, Maradan-Gachet, Marie Elise, Gutbrod, Klemens, Maldaner, Nicolai, Neidert, Marian C, Früh, Severin, Schwind, Marc, Bozinov, Oliver, Brugger, Peter, Keller, Emanuela, Marr, Angelina, Roux, Sébastien, and Regli, Luca

Subjects
610 Medicine & health
Abstract

OBJECTIVE While prior retrospective studies have suggested that delayed cerebral ischemia (DCI) is a predictor of neuropsychological deficits after aneurysmal subarachnoid hemorrhage (aSAH), all studies to date have shown a high risk of bias. This study was designed to determine the impact of DCI on the longitudinal neuropsychological outcome after aSAH, and importantly, it includes a baseline examination after aSAH but before DCI onset to reduce the risk of bias. METHODS In a prospective, multicenter study (8 Swiss centers), 112 consecutive alert patients underwent serial neuropsychological assessments (Montreal Cognitive Assessment [MoCA]) before and after the DCI period (first assessment, < 72 hours after aSAH; second, 14 days after aSAH; third, 3 months after aSAH). The authors compared standardized MoCA scores and determined the likelihood for a clinically meaningful decline of ≥ 2 points from baseline in patients with DCI versus those without. RESULTS The authors screened 519 patients, enrolled 128, and obtained complete data in 112 (87.5%; mean [± SD] age 53.9 ± 13.9 years; 66.1% female; 73% World Federation of Neurosurgical Societies [WFNS] grade I, 17% WFNS grade II, 10% WFNS grades III-V), of whom 30 (26.8%) developed DCI. MoCA z-scores were worse in the DCI group at baseline (-2.6 vs -1.4, p = 0.013) and 14 days (-3.4 vs -0.9, p < 0.001), and 3 months (-0.8 vs 0.0, p = 0.037) after aSAH. Patients with DCI were more likely to experience a decline of ≥ 2 points in MoCA score at 14 days after aSAH (adjusted OR [aOR] 3.02, 95% CI 1.07-8.54; p = 0.037), but the likelihood was similar to that in patients without DCI at 3 months after aSAH (aOR 1.58, 95% CI 0.28-8.89; p = 0.606). CONCLUSIONS Aneurysmal SAH patients experiencing DCI have worse neuropsychological function before and until 3 months after the DCI period. DCI itself is responsible for a temporary and clinically meaningful decline in neuropsychological function, but its effect on the MoCA score could not be measured at the time of the 3-month follow-up in patients with low-grade aSAH with little or no impairment of consciousness. Whether these findings can be extrapolated to patients with high-grade aSAH remains unclear. Clinical trial registration no.: NCT03032471 (ClinicalTrials.gov).

Published
2022
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9. Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage—Protocol of a Swiss Nationwide Observational Study (MoCA–DCI Study)

Author

Stienen, Martin N, Fung, Christian, Bijlenga, Philippe, Zumofen, Daniel W, Maduri, Rodolfo, Robert, Thomas, Seule, Martin A, Marbacher, Serge, Geisseler, Olivia, Brugger, Peter, Gutbrod, Klemens, Chicherio, Christian, Monsch, Andreas U, Beaud, Valérie, Rossi, Stefania, Früh, Severin, Schmid, Nicole, Smoll, Nicolas R, Keller, Emanuela, Regli, Luca, Bozinov, Oliver, Burkhardt, Jan-Karl, Esposito, Giuseppe, Germans, Menno R, Keller, Emanuela, Krayenbühl, Niklaus, Maldaner, Nicolai, Neidert, Marian C, Regli, Luca, Sebök, Martina, Serra, Carlo, Stienen, Martin N, Velz, Julia, Marbacher, Serge, Fandino, Javier, D’Alonzo, Donato, Galiagousis, Christine, Perren, Carline, Stoller, Andrea, Nedeltchev, Krassen, Guzman, Raphael, Mariani, Luigi, Zumofen, Daniel W, Schulz, Marianne, Neddersen, Heike, Blackham, Kristine, Beck, Jürgen, Fung, Christian, Goldberg, Johannes, Raabe, Andreas, Schöni, Daniel, Bartoli, Andrea, Baticam, Nalla Silva, Bijlenga, Philippe, Constanthin, Paul, Corniola, Marco, Goga, Cristina, Guatta, Ramona, Jannelli, Gianpaolo, May, Adrien, Moiraghi, Alessandro, Molliqaj, Granit, Schaller, Karl, Sprenger, Lima, Wälchli, Thomas, Daniel, Roy Thomas, Maduri, Rodolfo, Rocca, Alda, Chiappini, Alessio, Reinert, Michael, Robert, Thomas, Hlavica, Martin, Killeen, Timothy, Seule, Martin A, Weyerbrock, Astrid, Schmid, Nicole, Kälin, Andrea, Monsch, Andreas U, Waldmeier, Anja Larissa, Albert, Djana, Baas, Ulrike, Cazzoli, Dario, Chavas, Silvia, Gutbrod, Barbara, Gutbrod, Klemens, Heinemann, Dörthe, Hofer, Helene, Chicherio, Christian, Beaud, Valérie, Fiorillo, Léa, Wahl, Laurance, Rossi, Stefania, Zanchi, Fabiana, Früh, Severin, Zimmerer, Sylvia, Schwind, Marc, Brugger, Peter, Dannecker, Noemi, Geisseler, Olivia, Rothacher, Yannick, Schlosser, Ladina, Smoll, Nicolas R, Zweifel-Zehnder, Antoinette E, and Schatlo, Bawarjan

Published
2019
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10. [Relevance of Neuropsychology When Assessing Fitness to Drive After Stroke].

Author

Schwind M

Subjects
Humans, Quality of Life, Neuropsychology, Physicians
Abstract

Relevance of Neuropsychology When Assessing Fitness to Drive After Stroke Abstract: Under normal circumstances, the mobility of oneself is often taken for granted. After a brain injury the quality of life is different and getting back into society may be difficult. Observing the patient's remaining qualities, the doctor or guardian will present guidelines. Often the patient no longer thinks of his former life, but only thinks of his taken away freedom. The doctor or guardian is often blamed for this. The patient will either accept the circumstances or could become aggressive or resentful. It is important for all to come together and present future guidelines. For street safety it is important and a duty for both parties to look into and solve this problem.

Published
2023
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11. [Cognitive Screening by the Doctor - What makes sense?]

Author

Schwind M

Subjects
Cognition, Humans, Mass Screening, Neuropsychological Tests, Cognitive Dysfunction diagnosis, Dementia diagnosis, Physicians
Abstract

For initial cognitive diagnostics in the practice, various screening tools in the form of short paper-pencil-tests are available. Such initial screenings take between 5 and 15 minutes, but do not replace detailed neuropsychological diagnostics. Of the screening-tools reviewed, DemTect is suitable for suspected early onset dementia, while MMSE and MoCA cover other cognitive domains in greater detail. BrainCheck provides clear conclusion results and is recommended for practice. A more comprehensive diagnosis of dementia is not possible with the screening tools reviewed. However, they can help to decide whether a detailed dementia analysis is necessary or whether one can wait with it. The screening methods reviewed are freely available on the internet., Competing Interests: Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt besteht., (Thieme. All rights reserved.)

Published
2022
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