Search

Your search keyword '"Scigliuolo, Graziana Maria"' showing total 26 results
Start Over Author "Scigliuolo, Graziana Maria"
26 results on '"Scigliuolo, Graziana Maria"'

1. Cord blood transplantation for adult mature lymphoid neoplasms in Europe and Japan

Author

Watanabe, Mizuki, Kanda, Junya, Volt, Fernanda, Ruggeri, Annalisa, Suzuki, Ritsuro, Rafii, Hanadi, Kimura, Fumihiko, Cappelli, Barbara, Kondo, Eisei, Scigliuolo, Graziana Maria, Takahashi, Satoshi, Kenzey, Chantal, Rivera-Franco, Monica M., Okamoto, Shinichiro, Rocha, Vanderson, Chevallier, Patrice, Sanz, Jaime, Fürst, Sabine, Cornelissen, Jan, Milpied, Noel, Uchida, Naoyuki, Sugio, Yasuhiro, Kimura, Takafumi, Ichinohe, Tatsuo, Fukuda, Takahiro, Mohty, Mohamad, Peffault de Latour, Régis, Atsuta, Yoshiko, and Gluckman, Eliane

Published
2024
Full Text
View/download PDF

2. Impact of allele-level HLA matching on outcomes after double cord blood transplantation in adults with malignancies

Author

Fatobene, Giancarlo, Mariano, Livia, Volt, Fernanda, Moreira, Frederico, Conelissen, Jan, Furst, Sabine, Daguindau, Etienne, Sirvent, Anne, Peffault de Latour, Régis, Rafii, Hanadi, Rivera-Franco, Monica M., Kenzey, Chantal, Scigliuolo, Graziana Maria, Cappelli, Barbara, Ruggeri, Annalisa, Gluckman, Eliane, and Rocha, Vanderson

Published
2023
Full Text
View/download PDF

5. Umbilical Cord Blood Transplantation for Fanconi Anemia With a Special Focus on Late Complications: a Study on Behalf of Eurocord and SAAWP-EBMT

Author

Rafii, Hanadi, Volt, Fernanda, Bierings, Marc, Dalle, Jean-Hugues, Ayas, Mouhab, Rihani, Rawad, Faraci, Maura, de Simone, Giuseppina, Sengeloev, Henrik, Passweg, Jakob, Cavazzana, Marina, Costello, Regis, Maertens, Johan, Biffi, Alessandra, Johansson, Jan-Erik, Montoro, Juan, Guepin, Gabrielle Roth, Diaz, Miguel Angel, Sirvent, Anne, Kenzey, Chantal, Rivera Franco, Monica M., Cappelli, Barbara, Scigliuolo, Graziana Maria, Rocha, Vanderson, Ruggeri, Annalisa, Risitano, Antonio, De Latour, Regis Peffault, and Gluckman, Eliane

Published
2024
Full Text
View/download PDF

6. Cord blood transplantation for adult lymphoid neoplasms in Europe and Japan

Author

Watanabe, Mizuki, Kanda, Junya, Volt, Fernanda, Ruggeri, Annalisa, Suzuki, Ritsuro, Rafii-Elayoubi, Hanadi, Kimura, Fumihiko, Cappelli, Barbara, Kondo, Eisei, Scigliuolo, Graziana Maria, Takahashi, Satoshi, Kenzey, Chantal, Rivera Franco, Monica Magdalena, Okamoto, Shinichiro, Rocha, Vanderson, Chevallier, Patrice, Sanz, Jaime, Furst, Sabine, Cornelissen, Jan J., Milpied, Noël J, Uchida, Naoyuki, Sugio, Yasuhiro, Kimura, Takafumi, Ichinohe, Tatsuo, Fukuda, Takahiro, Mohty, Mohamad, Peffault de Latour, Régis, Atsuta, Yoshiko, Gluckman, Eliane, Watanabe, Mizuki, Kanda, Junya, Volt, Fernanda, Ruggeri, Annalisa, Suzuki, Ritsuro, Rafii-Elayoubi, Hanadi, Kimura, Fumihiko, Cappelli, Barbara, Kondo, Eisei, Scigliuolo, Graziana Maria, Takahashi, Satoshi, Kenzey, Chantal, Rivera Franco, Monica Magdalena, Okamoto, Shinichiro, Rocha, Vanderson, Chevallier, Patrice, Sanz, Jaime, Furst, Sabine, Cornelissen, Jan J., Milpied, Noël J, Uchida, Naoyuki, Sugio, Yasuhiro, Kimura, Takafumi, Ichinohe, Tatsuo, Fukuda, Takahiro, Mohty, Mohamad, Peffault de Latour, Régis, Atsuta, Yoshiko, and Gluckman, Eliane

Abstract

With the aim of identifying the different characteristics and prognostic factors of cord blood transplantation (CBT) in adult patients with lymphoid neoplasms in Europe and Japan, we conducted a collaborative study between European and Japanese registries. Patients aged 18-75 years receiving their first CBT (Europe: single CBT, n=192; double CBT, n=304; Japan: single CBT, n=1150) in 2000-2017 were analyzed. The number of patients with Hodgkin's lymphoma was higher in Europe (26% vs 5%) while that with mature T/NK-cell neoplasms was higher in Japan (20% vs 35%). The Japanese cohort comprised more elderly patients (>=50) (59% vs 39%) with higher refined disease risk index (rDRI) (high-very high: 49% vs 14%). High-very high rDRI (vs. low rDRI) was associated with inferior OS in common (Europe: HR 1.87 p=0.001; Japan: HR 2.34, p<0.001) with higher progression/relapse risks (Europe: HR 2.04, p=0.007; Japan: HR 2.96, p<0.001). Total body irradiation (TBI)-containing conditioning regimens contributed to superior OS both in Europe (vs TBI-RIC, non TBI-RIC: HR 1.93, p<0.001; non TBI-MAC: HR 1.90, p=0.003) and in Japan (non TBI-RIC: HR 1.71, p<0.001; non TBI-MAC: HR 1.50, p=0.007). The impact of HLA mismatches (>=2) on OS differed (Europe: HR 1.52, p=0.007; Japan: HR 1.18, p=0.107). Despite the different patient-disease-transplant characteristics, poor survival of patients receiving CBT for lymphoid neoplasms, especially in those with high rDRI was observed in both registries. The different impact of HLA mismatches on survival in the two registries calls attention to the fundamental differences among these populations. TBI should be considered in conditioning regimens.

Published
2024

8. HLA-Matched Unrelated Donors for Patients with Sickle Cell Disease: Results of International Donor Searches

Author

Tozatto-Maio, Karina, Torres, Margareth Afonso, Degaide, Neifi Hassan Saloum, Cardoso, Juliana Fernandes, Volt, Fernanda, Pinto, Ana Cristina Silva, Oliveira, Danielli, Elayoubi, Hanadi, Kashima, Simone, Loiseau, Pascale, Veelken, Hendrik, Ferster, Alina, Cappelli, Barbara, Rodrigues, Evandra Strazza, Scigliuolo, Graziana Maria, Kenzey, Chantal, Ruggeri, Annalisa, Rocha, Vanderson, Simões, Belinda Pinto, Tamouza, Ryad, and Gluckman, Eliane

Published
2020
Full Text
View/download PDF

9. HLA peptide‐binding pocket diversity modulates immunological complications after cord blood transplant in acute leukaemia.

Author

Boukouaci, Wahid, Rivera‐Franco, Monica M., Volt, Fernanda, Lajnef, Mohamed, Wu, Ching‐Lien, Rafii, Hanadi, Cappelli, Barbara, Scigliuolo, Graziana Maria, Kenzey, Chantal, Ruggeri, Annalisa, Rocha, Vanderson, Gluckman, Eliane, and Tamouza, Ryad

Subjects
ACUTE leukemia, CORD blood, HISTOCOMPATIBILITY antigens, GRAFT versus host disease, STEM cell transplantation, HLA histocompatibility antigens, HISTOCOMPATIBILITY class I antigens
Abstract

Summary: Pocket motifs and their amino acid positions of HLA molecules are known to govern antigen presentation to effector cells. Our objective was to analyse their influence on the risk of graft‐versus‐host disease (GVHD) and relapse after umbilical cord blood transplant (UCBT). The transplant characteristics of 849 patients with acute leukaemia were obtained from the Eurocord/EBMT database. Higher acute (a) GVHD was associated with homozygosity of UCB HLA‐C amino acid positions 77 and 80 (NN/KK) (p = 0.008). Severe aGVHD was associated with HLA‐A pocket B YSAVMENVHY motif (p = 0.002) and NN and RR genotypes of the HLA‐C amino acid positions 77 and 156 (p = 0.006 and p = 0.002). Such risk was also increased in case of recipient and UCB mismatches in P4 (p < 0.0001) and P9 (p = 0.003) pockets of HLA‐DQB1 alleles. For chronic GVHD, the pocket B YYAVMEISNY motif of the HLA‐B*15:01 allele and the absence of mismatch between recipient and UCB in the P6 pocket of HLA‐DRB1 were associated with a lower risk (p = 0.0007 and p = 0.0004). In relapse, both UCB pocket B YFAVMENVHY belonging to HLA‐A*32:01 and recipient pocket B YDSVGENYQY motif of the HLA‐C*07:01 allele were associated with higher risk (p = 0.0026 and p = 0.015). We provide clues on HLA‐mediated cellular interactions and their role in the development of GVHD and relapse. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Use of letermovir in umbilical cord blood transplantation based on risk scores

Author

Rivera Franco, Monica M., primary, Rafii, Hanadi, additional, Volt, Fernanda, additional, Kenzey, Chantal, additional, Cappelli, Barbara, additional, Scigliuolo, Graziana Maria, additional, Rocha, Vanderson, additional, Raus, Nicole, additional, Dalle, Jean-Hugues, additional, Chevallier, Patrice, additional, Robin, Marie, additional, Rubio, Marie Thérèse, additional, Ruggeri, Annalisa, additional, and Gluckman, Eliane, additional

Published
2023
Full Text
View/download PDF

12. Systematic Review/Meta-Analysis on Efficacy of Allogeneic Hematopoietic Cell Transplantation in Sickle Cell Disease: An International Effort on Behalf of the Pediatric Diseases Working Party of European Society for Blood and Marrow Transplantation and the Sickle Cell Transplantation International Consortium

Author

Iqbal, Madiha, Reljic, Tea, Corbacioglu, Selim, de la Fuente, Josu, Gluckman, Eliane, Kumar, Ambuj, Yassine, Farah, Ayala, Ernesto, El-Jawahri, Areej, Murthy, Hemant, Almohareb, Fahad, Hashmi, Shahrukh K., Cappelli, Barbara, Alahmari, Ali, Scigliuolo, Graziana Maria, Kassim, Adetola, Aljurf, Mahmoud, and Kharfan-Dabaja, Mohamed A.

Published
2021
Full Text
View/download PDF

13. Impact of Allele-Level HLA-Matching on Outcomes after Double Unrelated Cord Blood Transplantation in Adults with Malignant Diseases

Author

Fatobene, Giancarlo, primary, Mariano, Livia, additional, Volt, Fernanda, additional, Moreira, Frederico Rafael, additional, Cornelissen, Jan J., additional, Blaise, Didier, additional, Daguindau, Etienne, additional, Fegueux, Nathalie, additional, Peffault de Latour, Régis, additional, Rafii, Hanadi, additional, M Rivera-Franco, Monica, additional, Kenzey, Chantal, additional, Scigliuolo, Graziana Maria, additional, Cappelli, Barbara, additional, Ruggeri, Annalisa, additional, Gluckman, Eliane, additional, and Rocha, Vanderson, additional

Published
2022
Full Text
View/download PDF

14. Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia

Author

Boukouaci, Wahid, primary, Rivera‐Franco, Monica M., additional, Volt, Fernanda, additional, Wu, Ching‐Lien, additional, Rafii, Hanadi, additional, Cappelli, Barbara, additional, Scigliuolo, Graziana Maria, additional, Kenzey, Chantal, additional, Ruggeri, Annalisa, additional, Rocha, Vanderson, additional, Gluckman, Eliane, additional, and Tamouza, Ryad, additional

Published
2022
Full Text
View/download PDF

16. Possible Effect of the use of Mesenchymal Stromal Cells in the Treatment of Autism Spectrum Disorders: A Review

Author

Tamouza, Ryad, primary, Volt, Fernanda, additional, Richard, Jean-Romain, additional, Wu, Ching-Lien, additional, Bouassida, Jihène, additional, Boukouaci, Wahid, additional, Lansiaux, Pauline, additional, Cappelli, Barbara, additional, Scigliuolo, Graziana Maria, additional, Rafii, Hanadi, additional, Kenzey, Chantal, additional, Mezouad, Esma, additional, Naamoune, Soumia, additional, Chami, Leila, additional, Lejuste, Florian, additional, Farge, Dominique, additional, and Gluckman, Eliane, additional

Published
2022
Full Text
View/download PDF

18. Comparative analysis of the variability of the human leukocyte antigen peptide‐binding pockets in patients with acute leukaemia.

Author

Boukouaci, Wahid, Rivera‐Franco, Monica M., Volt, Fernanda, Wu, Ching‐Lien, Rafii, Hanadi, Cappelli, Barbara, Scigliuolo, Graziana Maria, Kenzey, Chantal, Ruggeri, Annalisa, Rocha, Vanderson, Gluckman, Eliane, and Tamouza, Ryad

Subjects
HLA histocompatibility antigens, ACUTE leukemia, HISTOCOMPATIBILITY antigens, ACUTE myeloid leukemia, LYMPHOBLASTIC leukemia, AMINO acids
Abstract

Summary: The association between acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) and the human leukocyte antigens (HLA) has rarely been studied in terms of diversity of peptide‐binding pockets. The objective of this study was to analyse whether motifs of HLA class I and class II peptide‐binding pockets and/or their amino acid positions were differentially associated with ALL and AML. We included 849 patients from the Eurocord/European Blood and Marrow Transplant registry. The HLA peptide‐binding pockets whose amino acid variability was analysed were B and F for HLA class I, P4, P6, and P9 for HLA‐DRB1, and P4 and P9 for HLA‐DQB1. The motif RFDRAY in P4 of HLA‐DRB1*16:01/02/03/05 alleles and the motif YYVSY in P9 of HLA‐DQB1*05:02/04/05 alleles, were statistically associated with ALL (corrected p value [pc] = 0.001 and pc = 0.035 respectively). The frequency of serine 57 in the P9 of HLA‐DQB1 was higher in ALL (odds ratio 2.09, 95% confidence interval: 1.27–3.44; pc = 0.037). Our analysis suggests that specific motifs in terms of HLA class II pockets and amino acids might be unique to ALL. The associations identified in this study encourage further investigation oF the role of HLA peptide‐binding pockets and their amino acids in immune processes underpinning acute leukaemia and ultimately in immunotherapy settings. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

20. Umbilical Cord Blood Transplantation after Graft Failure from a Previous Hematopoietic Stem Cell Transplantation

Author

Volt, Fernanda, primary, Ruggeri, Annalisa, additional, Scigliuolo, Graziana Maria, additional, Peffault De Latour, Regis, additional, Bierings, Marc, additional, Al-Seraihy, Amal, additional, Bittencourt, Henrique, additional, Labussiere-Wallet, Helene, additional, Rocha, Vanderson, additional, Kenzey, Chantal, additional, Cappelli, Barbara, additional, Rafii, Hanadi, additional, Gluckman, Eliane, additional, and Guerino-Cunha, Renato Luiz, additional

Published
2021
Full Text
View/download PDF

22. Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease

Author

Tozatto-Maio, Karina, primary, Girot, Robert, additional, Ly, Indou Deme, additional, Silva Pinto, Ana Cristina, additional, Rocha, Vanderson, additional, Fernandes, Francisco, additional, Diagne, Ibrahima, additional, Benzerara, Yahia, additional, Dinardo, Carla L., additional, Soler, Julia Pavan, additional, Kashima, Simone, additional, Araujo, Itauá Leston, additional, Kenzey, Chantal, additional, Fonseca, Guilherme H. H., additional, Rodrigues, Evandra S., additional, Volt, Fernanda, additional, Jarduli, Luciana, additional, Ruggeri, Annalisa, additional, Mariaselvam, Christina, additional, Gualandro, Sandra F. M., additional, Rafii, Hanadi, additional, Cappelli, Barbara, additional, Nogueira, Felipe Melo, additional, Scigliuolo, Graziana Maria, additional, Guerino-Cunha, Renato Luiz, additional, Malmegrim, Kelen Cristina Ribeiro, additional, Simões, Belinda P., additional, Gluckman, Eliane, additional, and Tamouza, Ryad, additional

Published
2020
Full Text
View/download PDF

23. Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease

Author

Cappelli, Barbara, Volt, Fernanda, Tozatto-Maio, Karina, Scigliuolo, Graziana Maria, Ferster, Alina, Dupont, Sophie, Simões, Belinda Pinto, Al-Seraihy, Amal, Aljurf, Mahmoud D, Almohareb, Fahad, Belendez, Cristina, Matthes, Susanne, Dhedin, Nathalie, Pondarre, Corinne, Dalle, Jean-Hugues, Bertrand, Yves, Vannier, Jean Pierre, Kuentz, Mathieu, Lutz, Patrick, Michel, Gérard, Rafii, Hanadi, Neven, Benedicte, Zecca, Marco, Bader, Peter, Cavazzana, Marina, Labopin, Myriam, Locatelli, Franco, Magnani, Alessandra, Ruggeri, Annalisa, Rocha, Vanderson, Bernaudin, Françoise, de La Fuente, Josu, Corbacioglu, Selim, Gluckman, Eliane, Eurocord, The Cellular Therapy and Immunobiology Working Party (CTIWP), The Paediatric Diseases Working Party (PDWP) of the EBMT, and UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Anemia, Graft vs Host Disease, Disease, Human leukocyte antigen, Anemia, Sickle Cell, Young Adult, HLA Antigens, hemic and lymphatic diseases, Medicine, Humans, Sibling, Young adult, Child, Online Only Articles, Survival rate, business.industry, Incidence (epidemiology), Histocompatibility Testing, Incidence, Age Factors, Hematopoietic Stem Cell Transplantation, Infant, Généralités, thalassemia, children, adults, Hematology, medicine.disease, Prognosis, Transplantation, Europe, Survival Rate, surgical procedures, operative, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Child, Preschool, HSCT, Female, business, Follow-Up Studies
Abstract

SCOPUS: le.j, info:eu-repo/semantics/published

Published
2019

24. Alternative Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease in Europe

Author

Cappelli, Barbara, primary, Scigliuolo, Graziana Maria, additional, Volt, Fernanda, additional, Corbacioglu, Selim, additional, de la Fuente, Josu, additional, Dhedin, Nathalie, additional, Pondarré, Corinne, additional, Foell, Juergen, additional, O' Boyle, Farah, additional, Lankester, Arjan, additional, Calore, Elisabetta, additional, Varotto, Stefania, additional, Zecca, Marco, additional, Al-Seraihy, Amal, additional, Aljurf, Mahmoud, additional, Fasth, Anders, additional, Bonanomi, Sonia, additional, Addari, Maria Carmen, additional, Locatelli, Franco, additional, Ferster, Alina, additional, Labarque, Veerle, additional, Bader, Peter, additional, Simões, Belinda Pinto, additional, Tozatto-Maio, Karina, additional, Rocha, Vanderson, additional, Kuentz, Mathieu, additional, Elayoubi, Hanadi, additional, Ruggeri, Annalisa, additional, Bernaudin, Francoise, additional, and Gluckman, Eliane, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results