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216 results on '"Scirè, C."'

1. The vacuum and cryogenics system of the SOXS spectrograph

Author

Scuderi, S., Bellassai, G., Di Benedetto, R., Martinetti, E., Micciché, A., Nicotra, G., Occhipinti, G., Sciré, C., Aliverti, M., Genoni, M., Vitali, F., Campana, S., Claudi, R., Schipani, P., Baruffolo, A., Ben-Ami, S., Capasso, G., Cosentino, R., D'Alessio, F., D'Avanzo, P., Hershko, O., Kuncarayakti, H., Landoni, M., Munari, M., Pignata, G., Radhakrishnan, K., Rubin, A., Young, D., Achren, J., Araiza-Duran, J. A., Arcavi, I., Battaini, F., Brucalassi, A., Bruch, R., Cappellaro, E., Colapietro, M., Della Valle, M., D'Orsi, S., Gal-Yam, A., Diaz, M. Hernandez, Kotilainen, J., Causi, G. Li, Marty, L., Mattila, S., Rappaport, M., Ricci, D., Riva, M., Salasnich, B., Smartt, S., Sanchez, R. Zanmar, Stritzinger, M., and Ventura, H. Perez

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

SOXS (Son Of X-Shooter) is a single object spectrograph built by an international consortium for the ESO NTT telescope. SOXS is based on the heritage of the X-Shooter at the ESO-VLT with two arms (UV-VIS and NIR) working in parallel, with a Resolution-Slit product of about 4500, capable of simultaneously observing over the entire band the complete spectral range from the U- to the H-band. SOXS will carry out rapid and long-term Target of Opportunity requests on a variety of astronomical objects. The SOXS vacuum and cryogenic control system has been designed to evacuate, cool down and maintain the UV-VIS detector and the entire NIR spectrograph to their operating temperatures. The design chosen allows the two arms to be operated independently. This paper describes the final design of the cryo-vacuum control system, its functionalities and the tests performed in the integration laboratories., Comment: 12 pages, 6 figures, SPIE proceedings of the conference Advances in Optical and Mechanical Technologies for Telescopes and Instrumentation IV

Published
2022

3. Formation of complex organic molecules in molecular clouds: acetaldehyde, vinyl alcohol, ketene, and ethanol via the 'energetic' processing of C$_2$H$_2$ ice

Author

Chuang, K. -J., Fedoseev, G., Scirè, C., Baratta, G. A., Jäger, C., Henning, Th., Linnartz, H., and Palumbo, M. E.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics, Physics - Chemical Physics
Abstract

The simultaneous detection of organic molecules of the form C$_2$H$_{\text{n}}$O, such as ketene (CH$_2$CO), acetaldehyde (CH$_3$CHO), and ethanol (CH$_3$CH$_2$OH), toward early star-forming regions offers hints of shared chemical history. Several reaction routes have been proposed and experimentally verified under various interstellar conditions to explain the formation pathways involved. Most noticeably, the non-energetic processing of C$_2$H$_2$ ice with OH-radicals and H-atoms was shown to provide formation routes to ketene, acetaldehyde, ethanol, and vinyl alcohol (CH$_2$CHOH) along the H$_2$O formation sequence on grain surfaces. In this work, the non-energetic formation scheme is extended with laboratory measurements focusing on the energetic counterpart, induced by cosmic rays penetrating the H$_2$O-rich ice mantle. The focus here is on the H$^+$ radiolysis of interstellar C$_2$H$_2$:H$_2$O ice analogs at 17 K. Ultra-high vacuum experiments were performed to investigate the 200 keV H$^+$ radiolysis chemistry of predeposited C$_2$H$_2$:H$_2$O ices, both as mixed and layered geometries. Fourier-transform infrared spectroscopy was used to monitor in situ newly formed species as a function of the accumulated energy dose (or H$^+$ fluence). The infrared (IR) spectral assignments are further confirmed in isotope labeling experiments using H$_2$$^{18}$O. The energetic processing of C$_2$H$_2$:H$_2$O ice not only results in the formation of (semi-) saturated hydrocarbons (C$_2$H$_4$ and C$_2$H$_6$) and polyynes as well as cumulenes (C$_4$H$_2$ and C$_4$H$_4$), but it also efficiently forms O-bearing COMs, including vinyl alcohol, ketene, acetaldehyde, and ethanol, for which the reaction cross-section and product composition are derived. A clear composition transition of the product, from H-poor to H-rich species, is observed as a function of the accumulated energy dose., Comment: 14 pages, 7 figures, 2 tables

Published
2021
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6. Broadband spectroscopy of astrophysical ice analogs. I. Direct measurement of complex refractive index of CO ice using terahertz time-domain spectroscopy

Author

Giuliano, B. M., Gavdush, A. A., Müller, B., Zaytsev, K. I., Grassi, T., Ivlev, A. V., Palumbo, M. E., Baratta, G. A., Scirè, C., Komandin, G. A., Yurchenko, S. O., and Caselli, P.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Context: Reliable, directly measured optical properties of astrophysical ice analogs in the infrared (IR) and terahertz (THz) range are missing. These parameters are of great importance to model the dust continuum radiative transfer in dense and cold regions, here thick ice mantles are present, and are necessary for the interpretation of future observations planned in the far-IR region. Aims: Coherent THz radiation allows direct measurement of the complex dielectric function (refractive index) of astrophysically relevant ice species in the THz range. Methods: The time-domain waveforms and the frequency-domain spectra of reference samples of CO ice, deposited at a temperature of 28.5 K and annealed to 33 K at different thicknesses, have been recorded. A new algorithm is developed to reconstruct the real and imaginary parts of the refractive index from the time-domain THz data. Results: The complex refractive index in the wavelength range of 1 mm - 150 ${\mu}$m (0.3 - 2.0 THz) has been determined for the studied ice samples, and compared with available data found in the literature. Conclusions: The developed algorithm of reconstructing the real and imaginary parts of the refractive index from the time-domain THz data enables, for the first time, the determination of optical properties of astrophysical ice analogs without using the Kramers-Kronig relations. The obtained data provide a benchmark to interpret the observational data from current ground based facilities as well as future space telescope missions, and have been used to estimate the opacities of the dust grains in presence of CO ice mantles.

Published
2019
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7. Characterization of the silicon+6LiF thermal neutron detection technique

Author

Pappalardo, A., Barbagallo, M., Cosentino, L., Marchetta, C., Musumarra, A., Scirè, C., Scirè, S., Vecchio, G., and Finocchiaro, P.

Subjects
Physics - Instrumentation and Detectors
Abstract

The worldwide need to replace 3He for the neutron detection has triggered R&D on new technologies and methods. A promising one is based on commercial solid state silicon detectors coupled with thin neutron converter layers containing 6Li. After proving the feasibility of this technique, we characterized the behavior of such a detector with different converter layer thicknesses. In this paper we also disentangle other contributions to the overall spectrum shape observed with this kind of detector, proving that its detection efficiency can be made reasonably high and that the gamma/neutron discrimination capability is comparable to the one of 3He tubes., Comment: Submitted to Nuclear Instruments and Methods in Physics Research, section A

Published
2015
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13. One year in review 2021: novelties in the treatment of rheumatoid arthritis

Author

Silvagni, E., Garifallia Sakellariou, Bortoluzzi, A., Giollo, A., Ughi, N., Vultaggio, L., Scirè, C. A., Silvagni, E, Sakellariou, G, Bortoluzzi, A, Giollo, A, Ughi, N, Vultaggio, L, and Scire, C

Subjects
Disease-modifying anti-rheumatic drug, JAK inhibitors, SARS-CoV-2, Precision medicine, Immunology, COVID-19, Comorbidity, Biological agents, Disease-modifying anti-rheumatic drugs, Rheumatoid arthritis, NO, Arthritis, Rheumatoid, JAK inhibitor, Rheumatology, Antirheumatic Agents, Biological agent, Humans, Immunology and Allergy, Rheumatoid arthriti
Abstract

Management of rheumatoid arthritis (RA) has evolved over the years as a result of better understanding of the role of different therapeutic strategies, as well as following an increasing availability of new disease-modifying antirheumatic drugs. However, the role of patients in sharing decisions, as well as the rules informing precision medicine or the principles to follow in case of specific comorbidities or extra-articular manifestations are still areas for improvement. Moreover, in 2020, the novel Coronavirus disease-19 outbreak has completely changed many attitudes in terms of assessment and treatment paradigms in most clinical diseases, including RA. In this narrative review, the authors report their specific point of view on the management of RA, based on a critical revision of literature published in 2020, focusing on relevant novelties and future research directions.

Published
2021

14. The European Solar Telescope

Author

Quintero Noda, C., primary, Schlichenmaier, R., additional, Bellot Rubio, L. R., additional, Löfdahl, M. G., additional, Khomenko, E., additional, Jurčák, J., additional, Leenaarts, J., additional, Kuckein, C., additional, González Manrique, S. J., additional, Gunár, S., additional, Nelson, C. J., additional, de la Cruz Rodríguez, J., additional, Tziotziou, K., additional, Tsiropoula, G., additional, Aulanier, G., additional, Aboudarham, J., additional, Allegri, D., additional, Alsina Ballester, E., additional, Amans, J. P., additional, Asensio Ramos, A., additional, Bailén, F. J., additional, Balaguer, M., additional, Baldini, V., additional, Balthasar, H., additional, Barata, T., additional, Barczynski, K., additional, Barreto Cabrera, M., additional, Baur, A., additional, Béchet, C., additional, Beck, C., additional, Belío-Asín, M., additional, Bello-González, N., additional, Belluzzi, L., additional, Bentley, R. D., additional, Berdyugina, S. V., additional, Berghmans, D., additional, Berlicki, A., additional, Berrilli, F., additional, Berkefeld, T., additional, Bettonvil, F., additional, Bianda, M., additional, Bienes Pérez, J., additional, Bonaque-González, S., additional, Brajša, R., additional, Bommier, V., additional, Bourdin, P.-A., additional, Burgos Martín, J., additional, Calchetti, D., additional, Calcines, A., additional, Calvo Tovar, J., additional, Campbell, R. J., additional, Carballo-Martín, Y., additional, Carbone, V., additional, Carlin, E. S., additional, Carlsson, M., additional, Castro López, J., additional, Cavaller, L., additional, Cavallini, F., additional, Cauzzi, G., additional, Cecconi, M., additional, Chulani, H. M., additional, Cirami, R., additional, Consolini, G., additional, Coretti, I., additional, Cosentino, R., additional, Cózar-Castellano, J., additional, Dalmasse, K., additional, Danilovic, S., additional, De Juan Ovelar, M., additional, Del Moro, D., additional, del Pino Alemán, T., additional, del Toro Iniesta, J. C., additional, Denker, C., additional, Dhara, S. K., additional, Di Marcantonio, P., additional, Díaz Baso, C. J., additional, Diercke, A., additional, Dineva, E., additional, Díaz-García, J. J., additional, Doerr, H.-P., additional, Doyle, G., additional, Erdelyi, R., additional, Ermolli, I., additional, Escobar Rodríguez, A., additional, Esteban Pozuelo, S., additional, Faurobert, M., additional, Felipe, T., additional, Feller, A., additional, Feijoo Amoedo, N., additional, Femenía Castellá, B., additional, Fernandes, J., additional, Ferro Rodríguez, I., additional, Figueroa, I., additional, Fletcher, L., additional, Franco Ordovas, A., additional, Gafeira, R., additional, Gardenghi, R., additional, Gelly, B., additional, Giorgi, F., additional, Gisler, D., additional, Giovannelli, L., additional, González, F., additional, González, J. B., additional, González-Cava, J. M., additional, González García, M., additional, Gömöry, P., additional, Gracia, F., additional, Grauf, B., additional, Greco, V., additional, Grivel, C., additional, Guerreiro, N., additional, Guglielmino, S. L., additional, Hammerschlag, R., additional, Hanslmeier, A., additional, Hansteen, V., additional, Heinzel, P., additional, Hernández-Delgado, A., additional, Hernández Suárez, E., additional, Hidalgo, S. L., additional, Hill, F., additional, Hizberger, J., additional, Hofmeister, S., additional, Jägers, A., additional, Janett, G., additional, Jarolim, R., additional, Jess, D., additional, Jiménez Mejías, D., additional, Jolissaint, L., additional, Kamlah, R., additional, Kapitán, J., additional, Kašparová, J., additional, Keller, C. U., additional, Kentischer, T., additional, Kiselman, D., additional, Kleint, L., additional, Klvana, M., additional, Kontogiannis, I., additional, Krishnappa, N., additional, Kučera, A., additional, Labrosse, N., additional, Lagg, A., additional, Landi Degl’Innocenti, E., additional, Langlois, M., additional, Lafon, M., additional, Laforgue, D., additional, Le Men, C., additional, Lepori, B., additional, Lepreti, F., additional, Lindberg, B., additional, Lilje, P. B., additional, López Ariste, A., additional, López Fernández, V. A., additional, López Jiménez, A. C., additional, López López, R., additional, Manso Sainz, R., additional, Marassi, A., additional, Marco de la Rosa, J., additional, Marino, J., additional, Marrero, J., additional, Martín, A., additional, Martín Gálvez, A., additional, Martín Hernando, Y., additional, Masciadri, E., additional, Martínez González, M., additional, Matta-Gómez, A., additional, Mato, A., additional, Mathioudakis, M., additional, Matthews, S., additional, Mein, P., additional, Merlos García, F., additional, Moity, J., additional, Montilla, I., additional, Molinaro, M., additional, Molodij, G., additional, Montoya, L. M., additional, Munari, M., additional, Murabito, M., additional, Núñez Cagigal, M., additional, Oliviero, M., additional, Orozco Suárez, D., additional, Ortiz, A., additional, Padilla-Hernández, C., additional, Paéz Mañá, E., additional, Paletou, F., additional, Pancorbo, J., additional, Pastor Cañedo, A., additional, Pastor Yabar, A., additional, Peat, A. W., additional, Pedichini, F., additional, Peixinho, N., additional, Peñate, J., additional, Pérez de Taoro, A., additional, Peter, H., additional, Petrovay, K., additional, Piazzesi, R., additional, Pietropaolo, E., additional, Pleier, O., additional, Poedts, S., additional, Pötzi, W., additional, Podladchikova, T., additional, Prieto, G., additional, Quintero Nehrkorn, J., additional, Ramelli, R., additional, Ramos Sapena, Y., additional, Rasilla, J. L., additional, Reardon, K., additional, Rebolo, R., additional, Regalado Olivares, S., additional, Reyes García-Talavera, M., additional, Riethmüller, T. L., additional, Rimmele, T., additional, Rodríguez Delgado, H., additional, Rodríguez González, N., additional, Rodríguez-Losada, J. A., additional, Rodríguez Ramos, L. F., additional, Romano, P., additional, Roth, M., additional, Rouppe van der Voort, L., additional, Rudawy, P., additional, Ruiz de Galarreta, C., additional, Rybák, J., additional, Salvade, A., additional, Sánchez-Capuchino, J., additional, Sánchez Rodríguez, M. L., additional, Sangiorgi, M., additional, Sayède, F., additional, Scharmer, G., additional, Scheiffelen, T., additional, Schmidt, W., additional, Schmieder, B., additional, Scirè, C., additional, Scuderi, S., additional, Siegel, B., additional, Sigwarth, M., additional, Simões, P. J. A., additional, Snik, F., additional, Sliepen, G., additional, Sobotka, M., additional, Socas-Navarro, H., additional, Sola La Serna, P., additional, Solanki, S. K., additional, Soler Trujillo, M., additional, Soltau, D., additional, Sordini, A., additional, Sosa Méndez, A., additional, Stangalini, M., additional, Steiner, O., additional, Stenflo, J. O., additional, Štěpán, J., additional, Strassmeier, K. G., additional, Sudar, D., additional, Suematsu, Y., additional, Sütterlin, P., additional, Tallon, M., additional, Temmer, M., additional, Tenegi, F., additional, Tritschler, A., additional, Trujillo Bueno, J., additional, Turchi, A., additional, Utz, D., additional, van Harten, G., additional, van Noort, M., additional, van Werkhoven, T., additional, Vansintjan, R., additional, Vaz Cedillo, J. J., additional, Vega Reyes, N., additional, Verma, M., additional, Veronig, A. M., additional, Viavattene, G., additional, Vitas, N., additional, Vögler, A., additional, von der Lühe, O., additional, Volkmer, R., additional, Waldmann, T. A., additional, Walton, D., additional, Wisniewska, A., additional, Zeman, J., additional, Zeuner, F., additional, Zhang, L. Q., additional, Zuccarello, F., additional, and Collados, M., additional

Published
2022
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15. OP0168 DEVELOPMENT OF AN ULTRASOUND SCORING SYSTEM FOR CPPD EXTENT: RESULTS FROM A DELPHI PROCESS AND WEB-RELIABILITY EXERCISE BY THE OMERACT US WORKING GROUP

Author

Sirotti, S., primary, Adinolfi, A., additional, Damiani, A., additional, Becce, F., additional, Cazenave, T., additional, Cipolletta, E., additional, Christiansen, S. N., additional, Delle Sedie, A., additional, Diaz, M., additional, Figus, F., additional, Filippucci, E., additional, Hammer, H. B., additional, Mandl, P., additional, Maccarter, D., additional, Micu, M., additional, Möller, I., additional, Mortada, M. A., additional, Mouterde, G., additional, Naredo, E., additional, Porta, F., additional, Reginato, A., additional, Sakellariou, G., additional, Schmidt, W. A., additional, Scirè, C. A., additional, Serban, T., additional, Vlad, V., additional, Vreju, F. A., additional, Wakefield, R., additional, Zufferey, P., additional, Sarzi-Puttini, P., additional, Iagnocco, A., additional, Pineda, C., additional, Keen, H., additional, D’agostino, M. A., additional, Terslev, L., additional, and Filippou, G., additional

Published
2022
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17. POS0276 TRADITION VS INNOVATION! CONVENTIONAL RADIOGRAPHY AND ULTRASOUND IN THE DIAGNOSIS OF CPPD: INSTRUCTIONS FOR USE

Author

Sirotti, S., primary, Becce, F., additional, Sconfienza, L. M., additional, Terslev, L., additional, Zanetti, A., additional, Naredo, E., additional, Zufferey, P., additional, Gutierrez, M., additional, Adinolfi, A., additional, Serban, T., additional, Maccarter, D., additional, Mouterde, G., additional, Scanu, A., additional, Möller, I., additional, Scirè, C. A., additional, Sarzi-Puttini, P., additional, Novo-Rivas, U., additional, Abhishek, A., additional, Choi, H., additional, Dalbeth, N., additional, Tedeschi, S., additional, Iagnocco, A., additional, Pineda, C., additional, Keen, H., additional, D’agostino, M. A., additional, and Filippou, G., additional

Published
2022
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18. POS0132 THE FIRST ALGORITHM TO INTEGRATE ULTRASONOGRAPHY IN THE DIAGNOSTIC PROCESS OF DIFFERENTIAL DIAGNOSIS OF INFLAMMATORY ARTHROPATHY IN CLINICAL PRACTICE: A STUDY FROM THE MSUS WORKING GROUP OF THE ITALIAN SOCIETY OF RHEUMATOLOGY

Author

Damiani, A., primary, Sakellariou, G., additional, Adinolfi, A., additional, Scirè, C. A., additional, Pacini, G., additional, Fiorentini, E., additional, Carboni, D., additional, Sirotti, S., additional, Sarzi-Puttini, P., additional, Madruga Dias, J., additional, Iagnocco, A., additional, and Filippou, G., additional

Published
2022
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19. OP0125 THE MANAGEMENT OF PREGNANCY IN AUTOIMMUNE RHEUMATIC DISEASES: ANALYSIS OF 758 PREGNANCIES FROM THE PROSPECTIVE NATIONWIDE P-RHEUM.IT STUDY (THE ITALIAN REGISTRY OF PREGNANCY IN THE RHEUMATIC DISEASES)

Author

Andreoli, L., primary, Gerardi, M. C., additional, Crisafulli, F., additional, Zanetti, A., additional, Rozza, D., additional, Gerosa, M., additional, Lini, D., additional, Filippini, M., additional, Fredi, M., additional, Nalli, C., additional, Lazzaroni, M. G., additional, Taglietti, M., additional, Franceschini, F., additional, Caporali, R., additional, Trespidi, L., additional, Erra, R., additional, Mosca, M., additional, Tani, C., additional, Zucchi, D., additional, Melissa, P., additional, Ruffilli, F., additional, Maranini, B., additional, Rovere-Querini, P., additional, Canti, V., additional, De Lorenzo, R., additional, Cutro, M. S., additional, Picerno, V., additional, Montecucco, C., additional, Ramoni, V., additional, Anelli, M. G., additional, Abbruzzese, A., additional, Serale, F., additional, Romeo, N., additional, Chimenti, M. S., additional, Cuomo, G., additional, Larosa, M., additional, Pata, A. P., additional, Iuliano, A., additional, Crepaldi, G., additional, Brucato, A., additional, Landolfi, G., additional, Carrara, G., additional, Bortoluzzi, A., additional, Scirè, C. A., additional, and Tincani, A., additional

Published
2022
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20. OP0252 FACTORS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRY

Author

Yeoh, S. A., primary, Gianfrancesco, M., additional, Lawson-Tovey, S., additional, Hyrich, K., additional, Strangfeld, A., additional, Gossec, L., additional, Carmona, L., additional, Mateus, E., additional, Schaefer, M., additional, Richez, C., additional, Hachulla, E., additional, Holmqvist, M., additional, Scirè, C. A., additional, Hasseli, R., additional, Jayatilleke, A., additional, Hsu, T., additional, D’Silva, K., additional, Pimentel-Quiroz, V., additional, Vasquez del Mercado, M., additional, Katsuyuki Shinjo, S., additional, Reis Neto, E., additional, Rocha, L., additional, Montandon, A. C. D. O. E. S., additional, Jordan, P., additional, Sirotich, E., additional, Hausmann, J., additional, Liew, J., additional, Jacobsohn, L., additional, Gore-Massy, M., additional, Sufka, P., additional, Grainger, R., additional, Bhana, S., additional, Wallace, Z., additional, Robinson, P., additional, Yazdany, J., additional, and Machado, P., additional

Published
2022
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25. A new monolithic silicon detector telescope with bidimensional sensitivity for imaging applications

Author

Amorini, F., Sipala, V., Cardella, G., Auditore, L., Boiano, C., Carbone, B., Castoldi, A., Di Pietro, A., Fallica, G., Figuera, P., Finocchiaro, P., Grassi, L., La Guidara, E., Guazzoni, C., Guazzoni, P., Lombardo, I., Loria, D., Pappalardo, A., Pirrone, S., Randazzo, N., Rizzo, F., Russo, G.V., Russotto, P., Scirè, C., Scirè, S., Trifirò, A., Trimarchi, M., Valvo, G., and Zetta, L.

Published
2010
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27. The two faces of the same medal… or maybe not? Comparing osteoarthritis and calcium pyrophosphate deposition disease: A laboratory and ultrasonographic study

Author

Georgios Filippou, Scanu, A., Adinolfi, A., Picerno, V., Toscano, C., Bortoluzzi, A., Frediani, B., Govoni, M., Punzi, L., Scirè, C. A., Filippou, G, Scanu, A, Adinolfi, A, Picerno, V, Toscano, C, Bortoluzzi, A, Frediani, B, Govoni, M, Punzi, L, and Scire, C

Subjects
crystal arthropathies, Immunology, Synovial fluid analysi, osteoarthritis, ultrasonography, knee, synovial fluid analysis, calcium pyrophosphate deposition disease, Awards and Prizes, Chondrocalcinosis, Calcium pyrophosphate deposition disease, Calcium Pyrophosphate, NO, Humans, Laboratories, Synovial Fluid, Osteoarthritis, Rheumatology, Immunology and Allergy, LS7_2, Knee, Osteoarthriti, Crystal arthropathie, Ultrasonography
Abstract

Objective Osteoarthritis (OA) and calcium pyrophosphate deposition disease (CPPD) are frequently associated but the real relation between these diseases is not still understood. The aim of this paper is to investigate the characteristics in terms of inflammation, anatomical changes and synovial fluid (SF) features in knees of patients with OA and CPPD. Methods Consecutive patients older than 55 years with knee pain and swelling were enrolled. All patients underwent a complete clinical examination, a US examination of the affected joint, arthrocentesis of the knee and analysis of synovial fluid, including dosing of inorganic ions and number of crystals. The gold standard for the diagnosis was the microscopic analysis of the SF. Results Sixty-seven patients were enrolled, 25 affected by OA and 42 by CPPD. At US, a significantly higher amount of effusion and synovitis was identified in patients with CPPD but there were no significant differences regarding structural changes. At the SF analysis, the white blood cell (WBC) count was higher in patients with CPPD who also presented a higher number of polymorphonuclear cells and a lower number of monocytes. Regarding the inorganic ion concentration, the statistical analysis did not reveal any differences. The number of crystals in the SF, correlated with a larger effusion, higher grade of synovitis and a higher WBC count. Conclusion A higher degree of inflammation was found in patients with CPPD. The findings suggest that longitudinal studies would be useful to better understand the evolution of the diseases and highlight the need for different treatment strategies.

Published
2021

30. OP0223 DEVELOPMENT AND PRELIMINARY VALIDATION OF ULTRASONOGRAPHIC DISEASE ACTIVITY AND DAMAGE SCORES IN PSORIATIC ARTHRITIS PATIENTS: RESULTS FROM THE UPSTREAM (ULTRASOUND IN PSORIATIC ARTHRITIS TREATMENT) STUDY

Author

Zabotti, A., primary, Piga, M., additional, Zanetti, A., additional, Canzoni, M., additional, Boffini, N., additional, Picerno, V., additional, Zanframundo, G., additional, Silvagni, E., additional, Giovannini, I., additional, Raffeiner, B., additional, Scolieri, P., additional, Mancini, P., additional, Parisi, S., additional, Bortoluzzi, A., additional, Sakellariou, G., additional, De Lucia, O., additional, Tinazzi, I., additional, Figus, F., additional, Idolazzi, L., additional, Lorenzin, M., additional, Callegher, S. Z., additional, Cauli, A., additional, Carrara, G., additional, Scirè, C. A., additional, and Iagnocco, A., additional

Published
2021
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31. OP0055 ULTRASOUND HALO SIGN AS A POTENTIAL MONITORING TOOL FOR PATIENTS WITH GIANT CELL ARTERITIS: A PROSPECTIVE ANALYSIS

Author

Ponte, C., primary, Monti, S., additional, Scirè, C. A., additional, Delvino, P., additional, Khmelinskii, N., additional, Milanesi, A., additional, Teixeira, V., additional, Brandolino, F., additional, Diamantino Saraiva, F. M., additional, Montecucco, C., additional, Fonseca, J. E., additional, Schmidt, W. A., additional, and Luqmani, R., additional

Published
2021
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33. POS0476 CAN LOW-DOSE ASPIRIN DURING PREGNANCY PREVENT THE DEVELOPMENT OF ADVERSE PREGNANCY OUTCOMES IN WOMEN WITH ARTHRITIS? DATA FROM THE P-RHEUM.it STUDY

Author

Lini, D., primary, Gerardi, M. C., additional, Zanetti, A., additional, Carrara, G., additional, Bortoluzzi, A., additional, Crisafulli, F., additional, Filippini, M., additional, Fredi, M., additional, Gorla, R., additional, Lazzaroni, M. G., additional, Nalli, C., additional, Taglietti, M., additional, Lojacono, A., additional, Zatti, S., additional, Scirè, C. A., additional, Andreoli, L., additional, Franceschini, F., additional, and Tincani, A., additional

Published
2021
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35. POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP

Author

Adinolfi, A., primary, Sirotti, S., additional, Sakellariou, G., additional, Cipolletta, E., additional, Filippucci, E., additional, Porta, F., additional, Sarzi-Puttini, P., additional, Scirè, C. A., additional, Keen, H., additional, Mandl, P., additional, Mouterde, G., additional, Pineda, C., additional, Terslev, L., additional, D’agostino, M. A., additional, Iagnocco, A., additional, and Filippou, G., additional

Published
2021
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36. POS1183 OUTCOMES OF COVID-19 INFECTION AMONG CHILDREN AND YOUNG PEOPLE WITH PRE-EXISTING RHEUMATIC AND MUSCULOSKELETAL DISEASES

Author

Kearsley-Fleet, L., primary, Lawson-Tovey, S., additional, Costello, R. E., additional, Belot, A., additional, Aeschlimann, F., additional, Melki, I., additional, Koné-Paut, I., additional, Clemente, D., additional, Pinedo Gago, M. C., additional, Svestkova, N., additional, Vinšová, N., additional, Hamad Saied, M., additional, Berkun, Y., additional, Wulffraat, N., additional, Eulert, S., additional, Scirè, C. A., additional, Strangfeld, A., additional, Mateus, E., additional, Machado, P., additional, Uziel, Y., additional, and Hyrich, K., additional

Published
2021
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37. POS0055 SARS-COV-2 OUTBREAK IN AUTOIMMUNE DISEASES: THE EURO-COVIMID STUDY

Author

Saadoun, D., primary, Vieira, M., additional, Vautier, M., additional, Baraliakos, X., additional, Andreica, I., additional, Da Silva, J. A. P., additional, Sousa, M., additional, Luis, M., additional, Khmelinskii, N., additional, Alvaro-Gracia, J. M., additional, Castrejon, I., additional, Nieto González, J. C., additional, Scirè, C. A., additional, Silvagni, E., additional, Bortoluzzi, A., additional, Penn, H., additional, Hamdulay, S., additional, Machado, P., additional, Fautrel, B., additional, Cacoub, P., additional, Resche-Rigon, M., additional, and Gossec, L., additional

Published
2021
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38. AB0822 BREASTFEEDING AMONG WOMEN WITH RHEUMATIC DISEASES: ANALYSIS OF DATA FROM THE P-RHEUM.IT STUDY

Author

Panaro, S., primary, Gerardi, M. C., additional, Filippini, M., additional, Crisafulli, F., additional, Fredi, M., additional, Gorla, R., additional, Lazzaroni, M. G., additional, Lini, D., additional, Nalli, C., additional, Moschetti, L., additional, Regola, F., additional, Taglietti, M., additional, Bortoluzzi, A., additional, Zanetti, A., additional, Lojacono, A., additional, Zatti, S., additional, Scirè, C. A., additional, Carrara, G., additional, Ramazzotto, F., additional, Andreoli, L., additional, Franceschini, F., additional, and Tincani, A., additional

Published
2021
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39. POS1132 DIAGNOSTIC ACCURACY OF CONVENTIONAL RADIOGRAPHY OF THE KNEE FOR CALCIUM PYROPHOSPHATE DEPOSITION DISEASE: AN ANCILLARY STUDY OF THE OMERACT ULTRASOUND – CPPD GROUP

Author

Sirotti, S., primary, Becce, F., additional, Sconfienza, L. M., additional, Pineda, C., additional, Gutierrez, M., additional, Serban, T., additional, Maccarter, D., additional, Adinolfi, A., additional, Naredo, E., additional, Scanu, A., additional, Scirè, C. A., additional, Möller, I., additional, Sarzi-Puttini, P., additional, Abhishek, A., additional, Choi, H., additional, Dalbeth, N., additional, Tedeschi, S., additional, D’agostino, M. A., additional, Keen, H., additional, Terslev, L., additional, Iagnocco, A., additional, and Filippou, G., additional

Published
2021
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40. POS1406 DEVELOPMENT OF A DIAGNOSTIC ALGORITHM FOR THE DIFFERENTIAL DIAGNOSIS OF INTERSTITIAL LUNG DISEASE: PRELIMINARY DATA FROM A MULTICENTER RETROSPECTIVE CASE-CONTROL STUDY

Author

Maranini, B., primary, Chiodin, T., additional, Scirè, C. A., additional, Govoni, M., additional, Lucioni, E., additional, Chiarello, S., additional, Scabbia, F., additional, Marchi, I., additional, Zanframundo, G., additional, Cavagna, L., additional, Bellis, E., additional, Silva, M., additional, Tringali, G., additional, and Carnevale, A., additional

Published
2021
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41. Imaging monolithic silicon detector telescopes

Author

Amorini, F., Sipala, V., Cardella, G., Boiano, C., Carbone, B., Cosentino, L., Costa, E., Di Pietro, A., Emanuele, U., Fallica, G., Figuera, P., Finocchiaro, P., La Guidara, E., Marchetta, C., Pappalardo, A., Piazza, A., Randazzo, N., Rizzo, F., Russo, G.V., Russotto, P., Scirè, C., Scirè, S., Trifirò, A., Trimarchi, M., and Valvo, G.

Published
2008
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42. OP0317 ACCURACY OF THE OMERACT DEFINITIONS FOR IDENTIFICATION OF CALCIUM PYROPHOSPHATE CRYSTALS WITH ULTRASOUND: FINAL RESULTS OF THE OMERACT US IN CPPD SUB-TASK FORCE STUDY

Author

Filippou, G., primary, Scanu, A., additional, Adinolfi, A., additional, Toscano, C., additional, Gambera, D., additional, Largo, R., additional, Naredo, E., additional, Calvo, E., additional, Herrero-Beaumont, G., additional, Zufferey, P., additional, Madelaine-Bonjour, C., additional, Maccarter, D., additional, Makman, S., additional, Weber, Z., additional, Figus, F., additional, Möller, I., additional, Gutierrez, M., additional, Pineda, C., additional, Clavijo Cornejo, D., additional, García, H., additional, Ilizaliturri, V., additional, Mendoza Torres, J., additional, Pichardo, R., additional, Rodriguez Delgado, L. C., additional, Filippucci, E., additional, Cipolletta, E., additional, Serban, T., additional, Cirstoiu, C., additional, Vreju, F. A., additional, Grecu, D., additional, Mouterde, G., additional, Govoni, M., additional, Punzi, L., additional, Damjanov, N., additional, Terslev, L., additional, Scirè, C. A., additional, and Iagnocco, A., additional

Published
2020
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44. OP0063 QUANTITATIVE COMPUTED TOMOGRAPHY PREDICTS 10-YEAR MORTALITY IN INTERSTITIAL LUNG DISEASE RELATED TO SYSTEMIC SCLEROSIS

Author

Ariani, A., primary, Bravi, E., additional, De Santis, M., additional, Hax, V., additional, Parisi, S., additional, Lumetti, F., additional, Girelli, F., additional, Saracco, M., additional, De Gennaro, F., additional, Giollo, A., additional, Abdel Jaber, M., additional, Bozzao, F., additional, Silva, M., additional, Ditto, M. C., additional, Lomater, C., additional, Mozzani, F., additional, Santilli, D., additional, Di Donato, E., additional, Becciolini, A., additional, Pucciarini, F., additional, Canziani, L., additional, Bodini, F. C., additional, Arrigoni, E., additional, Bredemeier, M., additional, Mendonça Da Silva Chakr, R., additional, Spinella, A., additional, Idolazzi, L., additional, Bortolotti, R., additional, Tomietto, P., additional, Baratella, E., additional, Tollot, S., additional, Giuggioli, D., additional, Fischetti, F., additional, Fusaro, E., additional, Sverzellati, N., additional, and Scirè, C. A., additional

Published
2020
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45. SAT0412 ACCURACY OF AN INSTRUMENT FOR SCREENING PSORIATIC ARTHRITIS AMONG PSORIATIC PATIENTS: RESULTS FROM THE MULTICENTRE ITALIAN STUDY HERACLES (SCREENING STRATEGIES FOR RHEUMATOLOGICAL REFERRAL OF PSORIATIC SUBJECTS AIMED TO DISCLOSE PSORIATIC ARTHRITIS)

Author

De Marco, G., primary, Manara, M., additional, Gisondi, P., additional, Idolazzi, L., additional, Ramonda, R., additional, Piaserico, S., additional, Cauli, A., additional, Cimmino, M. A., additional, Tomatis, V., additional, Salvarani, C., additional, Scrivo, R., additional, Zanetti, A., additional, Carrara, G., additional, Scirè, C. A., additional, Cattaneo, A., additional, and Marchesoni, A., additional

Published
2020
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46. Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept

Author

Generali, E., Carrara, G., Selmi, C., Verstappen, S., Zambon, A., Bortoluzzi, A., Ettore Silvagni, Scirè, C. A., Generali, E, Carrara, G, Selmi, C, Verstappen, S, Zambon, A, Bortoluzzi, A, Silvagni, E, and Scirè, C

Subjects
Adult, Male, Risk, ResearchInstitutes_Networks_Beacons/MICRA, Epidemiology, Middle Aged, Antibodies, Monoclonal, Humanized, Cardiovascular disease, NO, Etanercept, Arthritis, Rheumatoid, Hospitalization, Manchester Institute for Collaborative Research on Ageing, Retrospective Studie, Cardiovascular Diseases, Humans, Female, Biological therapy, Rheumatoid arthritis, Rheumatoid arthriti, Human, Aged, Retrospective Studies
Abstract

Objective. To verify if tocilizumab (TCZ) is associated with an increased risk of cardiovascular (CV) events compared with etanercept (ETN) in rheumatoid arthritis (RA). Methods. This is a retrospective cohort study on administrative healthcare databases (AHD) in Italy. Patients were identified using a validated algorithm based on AHD. Exposure to specific drugs was estimated by the drug prescription recorded in the AHD. The occurrence of acute CV events (myocardial infarction, stroke, other CV events) was derived from the hospital discharge forms. The association between TCZ or ETN and CV events was estimated using competing risk models, adjusting for pre-specified confounders. Results. We identified 1,752 subjects with RA, 1,086 treated with ETN and 666 with TCZ. TCZ did not increase the overall risk of acute CV events, even when adjusted for pre-specified confounders (hazard ratio HR 0.95, 95% confidence interval 95%CI 0.54-1.66), specifically of acute myocardial infarction (HR 0.39, 95%CI 0.15-1.06), stroke (HR 1.44, 95%CI 0.24-8.68) or other CV event (1.07, 95%CI 0.59-1.92). Conclusion. RA patients with TCZ do not have a medium-term excess of CV risk in patients compared with ETN.

Published
2018

47. One year in review 2019: novelties in the treatment of rheumatoid arthritis

Author

Ettore Silvagni, Di Battista, M., Bonifacio, A. F., Zucchi, D., Governato, G., Scirè, C. A., Silvagni, E, Di Battista, M, Bonifacio, A, Zucchi, D, Governato, G, and Scire, C

Subjects
rheumatoid arthritis, treatment, rheumatoid arthriti, biological DMARDs, rheumatoid arthritis, biological DMARDs, targeted synthetic DMARDs, conventional synthetic DMARDs, management, conventional synthetic DMARDs, targeted synthetic DMARDs, NO, Arthritis, Rheumatoid, Antirheumatic Agents, Quality of Life, Humans, Drug Therapy, Combination, management
Abstract

The current treatment approach in rheumatoid arthritis (RA) follows a stepwise management, starting from early introduction of conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs), moving to biological (b) DMARDs and targeted synthetic (ts) DMARDs. In the last few years, new drugs with different mechanisms of action have demonstrated their efficacy in treating such a disabling condition, and their approval, along with other more "experienced" treatments, has established their effectiveness on disease activity, damage accrual prevention, patients' quality of life improvement, confirming their safety profile. Moreover, new molecular pathways are under investigation as potential targets of new advanced therapies. Clinicians' capability of stratifying treatment strategies and decisions has improved, with several new tools for the optimisation of long-term management of RA; however, a high proportion of patients are refractory to the available drugs. Finally, as RA is a systemic disease, the knowledge in multi-systemic complications of the disease has grown, as well as the possibility in improving extra-articular manifestations of the disease, although certain drugs have potentially relevant non-articular effects, which need to be monitored. This narrative review summarises the most relevant studies published over the last year in the field of treatment of RA, with the major aim to let clinicians and researchers reflect on "what is new", "what is effective" and "what is safe".

Published
2019

48. Italian recommendations for influenza and pneumococcal vaccination in adult patients with autoimmune rheumatic diseases

Author

Guerrini, G., Franzetti, F., Giacomelli, R., Meroni, L., Riva, A., Scirè, C. A., Scrivo, R., Tavio, M., Agostinone, A., Airò, P., Atzeni, F., Bartalesi, F., Bazzichi, L., Berardicurti, O., Cassola, G., antonella castagna, Castelli, F., Cattelan, A., Citriniti, G., Cristini, F., Rosa, F., Fracassi, E., Galloway, J., La Paglia, G. M. C., Moioli, M. C., Ripamonti, D., Saracino, A., Tani, C., Tascini, C., Tieghi, T., Tinelli, M., Zabotti, A., Sarzi-Puttini, P., Galli, M., Guerrini, G, Franzetti, F, Giacomelli, R, Meroni, L, Riva, A, Scire, C, Scrivo, R, Tavio, M, Agostinone, A, Airo, P, Atzeni, F, Bartalesi, F, Bazzichi, L, Berardicurti, O, Cassola, G, Castagna, A, Castelli, F, Cattelan, A, Citriniti, G, Cristini, F, De Rosa, F, Fracassi, E, Galloway, J, La Paglia, G, Moioli, M, Ripamonti, D, Saracino, A, Tani, C, Tascini, C, Tieghi, T, Tinelli, M, Zabotti, A, Sarzi-Puttini, P, Galli, M, Guerrini, Giulio, Franzetti, Fabio, Giacomelli, Roberto, Meroni, Luca, Riva, Agostino, Scirè, Carlo Alberto, Scrivo, Rossana, Tavio, Marcello, Agostinone, Adriana, Airò, Paolo, Atzeni, Fabiola, Bartalesi, Filippo, Bazzichi, Laura, Berardicurti, Onorina, Cassola, Giovanni, Castagna, Antonella, Castelli, Francesco, Cattelan, Annamaria, Citriniti, Giorgia, Cristini, Francesco, De Rosa, Francesco, Fracassi, Elena, Galloway, Jame, La Paglia, Giuliana Maria Concetta, Moioli, Maria Cristina, Ripamonti, Diego, Saracino, Annalisa, Tani, Chiara, Tascini, Carlo, Tieghi, Tiziana, Tinelli, Marco, Zabotti, Alen, Sarzi-Puttini, Piercarlo, and Galli, Massimo

Subjects
Adult, Male, pneumococcal vaccine, Consensus, infuenza vaccine, Immunology, vaccination, autoimmune disease, NO, recommendations, influenza vaccination, pneumococcal vaccination, autoimmune rheumatic diseases, Autoimmune Diseases, Pneumococcal Vaccines, Rheumatology, Rheumatic Diseases, Influenza, Human, Pneumonia, Staphylococcal, Immunology and Allergy, Humans, disease-modifying anti-rheumatic drugs, Evidence-Based Medicine, Vaccination, Pneumonia, Influenza, disease-modifying anti-rheumatic drugs, autoimmune rheumatic diseases, infuenza vaccine, pneumococcal vaccine, Italy, Influenza Vaccines, Staphylococcal, Female, Immunosuppressive Agents, Human
Abstract

OBJECTIVES: To provide evidence-based recommendations for vaccination against influenza virus and S. pneumoniae in patients with autoimmune rheumatic diseases (ARDs). METHODS: A Consensus Committee including physicians with expertise in rheumatic and infectious diseases was established by two Italian scientific societies, Società Italiana di Reumatologia (SIR) and Società Italiana di Malattie Infettive e Tropicali (SIMIT). The experts were invited to develop evidence-based recommendations concerning vaccinations in ARDs patients, based on their clinical status before and after undergoing immunosuppressive treatments. Key clinical questions were formulated for the systematic literature reviews, based on the clinical pathway. A search was made in Medline (via PubMed) according to the original MeSH strategy from October 2009 and a keyword strategy from January 2016 up to December 2017, updating existing EULAR recommendations. Specific recommendations were separately voted and scored from 0 (no agreement with) to 100 (maximal agreement) and supporting evidence graded. The mean and standard deviation of the scores were calculated to determine the level of agreement among the experts' panel for each recommendation. Total cumulative agreement ≥70 defined consensus for each statement. RESULTS: Nine recommendations, based on 6 key clinical questions addressed by the expert committee, were proposed. The aim of this work is to integrate the 2011 EULAR recommendations on vaccination against influenza and S. pneumoniae in ARDs patients. An implementation plan was proposed to improve the vaccination status of these patients and their safety during immunosuppressive treatments. CONCLUSIONS: Influenza and pneumococcus vaccinations are effective and safe in patients with ARDs. More efforts should be made to translate the accumulated evidence into practice.

Published
2019

49. A Robotic arm for optical and gamma radwaste inspection

Author

Russo L., Cosentino L., Pappalardo A., Piscopo M., Scirè C., Scirè S., Vecchio G., Muscato G., and Finocchiaro P.

Subjects
Physics, QC1-999
Abstract

We propose Radibot, a simple and cheap robotic arm for remote inspection, which interacts with the radwaste environment by means of a scintillation gamma detector and a video camera representing its light (< 1 kg) payload. It moves vertically thanks to a crane, while the other three degrees of freedom are obtained by means of revolute joints. A dedicated algorithm allows to automatically choose the best kinematics in order to reach a graphically selected position, while still allowing to fully drive the arm by means of a standard videogame joypad.

Published
2014
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