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2. International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020).

Author

Farmer, Adam, Strzelczyk, Adam, Finisguerra, Alessandra, Gourine, Alexander, Gharabaghi, Alireza, Hasan, Alkomiet, Burger, Andreas, Jaramillo, Andrés, Mertens, Ann, Majid, Arshad, Verkuil, Bart, Badran, Bashar, Ventura-Bort, Carlos, Gaul, Charly, Beste, Christian, Warren, Christopher, Quintana, Daniel, Hämmerer, Dorothea, Freri, Elena, Frangos, Eleni, Tobaldini, Eleonora, Kaniusas, Eugenijus, Rosenow, Felix, Capone, Fioravante, Panetsos, Fivos, Ackland, Gareth, Kaithwas, Gaurav, OLeary, Georgia, Genheimer, Hannah, Jacobs, Heidi, Van Diest, Ilse, Schoenen, Jean, Redgrave, Jessica, Fang, Jiliang, Deuchars, Jim, Széles, Jozsef, More, Kaushik, Vonck, Kristl, Steenbergen, Laura, Vianna, Lauro, McTeague, Lisa, Ludwig, Mareike, Veldhuizen, Maria, De Couck, Marijke, Casazza, Marina, Keute, Marius, Bikson, Marom, Andreatta, Marta, DAgostini, Martina, Weymar, Mathias, Betts, Matthew, Prigge, Matthias, Kaess, Michael, Roden, Michael, Thai, Michelle, Schuster, Nathaniel, Montano, Nicola, Hansen, Niels, Kroemer, Nils, Rong, Peijing, Fischer, Rico, Howland, Robert, Sclocco, Roberta, Sellaro, Roberta, Garcia, Ronald, Bauer, Sebastian, Gancheva, Sofiya, Stavrakis, Stavros, Kampusch, Stefan, Deuchars, Susan, Wehner, Sven, Laborde, Sylvain, Usichenko, Taras, Polak, Thomas, Zaehle, Tino, Borges, Uirassu, Teckentrup, Vanessa, Jandackova, Vera, Napadow, Vitaly, Koenig, Julian, and Thayer, Julian

Subjects
guidelines & recommendations, minimum reporting standards, transcutaneous auricular vagus nerve stimulation, transcutaneous cervical vagus nerve stimulation, transcutaneous vagus nerve stimulation
Abstract

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation(VNS) and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice.

Published
2020

5. Electroceuticals and Magnetoceuticals in Gastroenterology.

Author

Song, Gengqing, Sclocco, Roberta, Sharma, Amol, Guerrero-López, Ingrid, and Kuo, Braden

Subjects
*VAGUS nerve stimulation, *INFLAMMATORY bowel diseases, *GASTROINTESTINAL motility disorders, *THERAPEUTICS, *ELECTROACUPUNCTURE
Abstract

In the realm of gastroenterology, the inadequacy of current medical treatments for gastrointestinal (GI) motility disorders and inflammatory bowel disease (IBD), coupled with their potential side effects, necessitates novel therapeutic approaches. Neuromodulation, targeting the nervous system's control of GI functions, emerges as a promising alternative. This review explores the promising effects of vagal nerve stimulation (VNS), magnetic neuromodulation, and acupuncture in managing these challenging conditions. VNS offers targeted modulation of GI motility and inflammation, presenting a potential solution for patients not fully relieved from traditional medications. Magnetic neuromodulation, through non-invasive means, aims to enhance neurophysiological processes, showing promise in improving GI function and reducing inflammation. Acupuncture and electroacupuncture, grounded in traditional medicine yet validated by modern science, exert comprehensive effects on GI physiology via neuro-immune-endocrine mechanisms, offering relief from motility and inflammatory symptoms. This review highlights the need for further research to refine these interventions, emphasizing their prospective role in advancing patient-specific management strategies for GI motility disorders and IBD, thus paving the way for a new therapeutic paradigm. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Multimodal ultrasound muscle assessment in patients with rheumatic diseases: a patient-based reliability study

Author

Smerilli, Gianluca, primary, Moscioni, Erica, additional, Sclocco, Roberta, additional, Lommano, Maria Giovanna, additional, Cipolletta, Edoardo, additional, Maccarrone, Vincenzo, additional, Farah, Sonia, additional, De Angelis, Rossella, additional, Salaffi, Fausto, additional, Grassi, Walter, additional, Filippucci, Emilio, additional, and Di Matteo, Andrea, additional

Published
2023
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13. Brain-to-brain mechanisms underlying pain empathy and social modulation of pain in the patient-clinician interaction.

Author

Ellingsen, Dan-Mikael, Isenburg, Kylie, Changjin Jung, Jeungchan Lee, Gerber, Jessica, Mawla, Ishtiaq, Sclocco, Roberta, Grahl, Arvina, Anzolin, Alessandra, Edwards, Robert R., Kelley, John M., Kirsch, Irving, Kaptchuk, Ted J., and Napadow, Vitaly

Subjects
THERAPEUTIC alliance, SOMATOSENSORY cortex, EMPATHY, PREFRONTAL cortex, SOCIAL interaction
Abstract

Social interactions such as the patient-clinician encounter can influence pain, but the underlying dynamic interbrain processes are unclear. Here, we investigated the dynamic brain processes supporting social modulation of pain by assessing simultaneous brain activity (fMRI hyperscanning) from chronic pain patients and clinicians during video-based live interaction. Patients received painful and nonpainful pressure stimuli either with a supportive clinician present (Dyadic) or in isolation (Solo). In half of the dyads, clinicians performed a clinical consultation and intake with the patient prior to hyperscanning (Clinical Interaction), which increased self-reported therapeutic alliance. For the other half, patient--clinician hyperscanning was completed without prior clinical interaction (No Interaction). Patients reported lower pain intensity in the Dyadic, relative to the Solo, condition. In Clinical Interaction dyads relative to No Interaction, patients evaluated their clinicians as better able to understand their pain, and clinicians were more accurate when estimating patients' pain levels. In Clinical Interaction dyads, compared to No Interaction, patients showed stronger activation of the dorsolateral and ventrolateral prefrontal cortex (dlPFC and vlPFC) and primary (S1) and secondary (S2) somatosensory areas (Dyadic-Solo contrast), and clinicians showed increased dynamic dlPFC concordance with patients' S2 activity during pain. Furthermore, the strength of S2-dlPFC concordance was positively correlated with self-reported therapeutic alliance. These findings support that empathy and supportive care can reduce pain intensity and shed light on the brain processes underpinning social modulation of pain in patient-clinician interactions. Our findings further suggest that clinicians' dlPFC concordance with patients' somatosensory processing during pain can be boosted by increasing therapeutic alliance. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Cine gastric MRI reveals altered Gut–Brain Axis in Functional Dyspepsia: gastric motility is linked with brainstem‐cortical fMRI connectivity

Author

Sclocco, Roberta, primary, Fisher, Harrison, additional, Staley, Rowan, additional, Han, Kyungsun, additional, Mendez, April, additional, Bolender, Andrew, additional, Coll‐Font, Jaume, additional, Kettner, Norman W., additional, Nguyen, Christopher, additional, Kuo, Braden, additional, and Napadow, Vitaly, additional

Published
2022
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17. Su1419: TRANSCUTANEOUS AURICULAR VAGUS NERVE STIMULATION INCREASES GASTRIC PERISTALTIC VELOCITY AND MEAL EMPTYING IN FUNCTIONAL DYSPEPSIA – A 4D CINE-MRI STUDY

Author

Sclocco, Roberta, primary, Fisher, Harrison P., additional, Staley, Rowan, additional, Bolender, Andrew, additional, Han, Kyungsun, additional, Coll-Font, Jaume, additional, Nguyen, Christopher, additional, Kettner, Norman W., additional, Napadow, Vitaly, additional, and Kuo, Braden, additional

Published
2022
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21. Neuroimmune signatures in chronic low back pain subtypes

Author

Alshelh, Zeynab, primary, Brusaferri, Ludovica, additional, Saha, Atreyi, additional, Morrissey, Erin, additional, Knight, Paulina, additional, Kim, Minhae, additional, Zhang, Yi, additional, Hooker, Jacob M, additional, Albrecht, Daniel, additional, Torrado-Carvajal, Angel, additional, Placzek, Michael S, additional, Akeju, Oluwaseun, additional, Price, Julie, additional, Edwards, Robert R, additional, Lee, Jeungchan, additional, Sclocco, Roberta, additional, Catana, Ciprian, additional, Napadow, Vitaly, additional, and Loggia, Marco L, additional

Published
2021
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23. Cover Image

Author

Sclocco, Roberta, primary, Nguyen, Christopher, additional, Staley, Rowan, additional, Fisher, Harrison, additional, Mendez, April, additional, Velez, Christopher, additional, Kettner, Norman W., additional, Kuo, Braden, additional, and Napadow, Vitaly, additional

Published
2021
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27. Causal dynamics of patient/clinician facial expression transfer are associated with insula cortex brain-to-brain concordance

Author

Duggento, Andrea, primary, Ellingsen, Dan-Mikael, additional, Isenburg, Kylie, additional, Jung, Changjin, additional, Lee, Jeungchan, additional, Gerber, Jessica, additional, Mawla, Ishtiaq, additional, Sclocco, Roberta, additional, Edwards, Robert R., additional, Kelley, John M., additional, Kirsch, Irving, additional, Kaptchuk, Ted J., additional, Toschi, Nicola, additional, and Napadow, Vitaly, additional

Published
2021
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31. International Consensus Based Review and Recommendations for Minimum Reporting Standards in Research on Transcutaneous Vagus Nerve Stimulation (Version 2020)

Author

Farmer, Adam D., primary, Strzelczyk, Adam, additional, Finisguerra, Alessandra, additional, Gourine, Alexander V., additional, Gharabaghi, Alireza, additional, Hasan, Alkomiet, additional, Burger, Andreas M., additional, Jaramillo, Andrés M., additional, Mertens, Ann, additional, Majid, Arshad, additional, Verkuil, Bart, additional, Badran, Bashar W., additional, Ventura-Bort, Carlos, additional, Gaul, Charly, additional, Beste, Christian, additional, Warren, Christopher M., additional, Quintana, Daniel S., additional, Hämmerer, Dorothea, additional, Freri, Elena, additional, Frangos, Eleni, additional, Tobaldini, Eleonora, additional, Kaniusas, Eugenijus, additional, Rosenow, Felix, additional, Capone, Fioravante, additional, Panetsos, Fivos, additional, Ackland, Gareth L., additional, Kaithwas, Gaurav, additional, O'Leary, Georgia H., additional, Genheimer, Hannah, additional, Jacobs, Heidi I. L., additional, Van Diest, Ilse, additional, Schoenen, Jean, additional, Redgrave, Jessica, additional, Fang, Jiliang, additional, Deuchars, Jim, additional, Széles, Jozsef C., additional, Thayer, Julian F., additional, More, Kaushik, additional, Vonck, Kristl, additional, Steenbergen, Laura, additional, Vianna, Lauro C., additional, McTeague, Lisa M., additional, Ludwig, Mareike, additional, Veldhuizen, Maria G., additional, De Couck, Marijke, additional, Casazza, Marina, additional, Keute, Marius, additional, Bikson, Marom, additional, Andreatta, Marta, additional, D'Agostini, Martina, additional, Weymar, Mathias, additional, Betts, Matthew, additional, Prigge, Matthias, additional, Kaess, Michael, additional, Roden, Michael, additional, Thai, Michelle, additional, Schuster, Nathaniel M., additional, Montano, Nicola, additional, Hansen, Niels, additional, Kroemer, Nils B., additional, Rong, Peijing, additional, Fischer, Rico, additional, Howland, Robert H., additional, Sclocco, Roberta, additional, Sellaro, Roberta, additional, Garcia, Ronald G., additional, Bauer, Sebastian, additional, Gancheva, Sofiya, additional, Stavrakis, Stavros, additional, Kampusch, Stefan, additional, Deuchars, Susan A., additional, Wehner, Sven, additional, Laborde, Sylvain, additional, Usichenko, Taras, additional, Polak, Thomas, additional, Zaehle, Tino, additional, Borges, Uirassu, additional, Teckentrup, Vanessa, additional, Jandackova, Vera K., additional, Napadow, Vitaly, additional, and Koenig, Julian, additional

Published
2021
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33. Neuroimmune signatures in chronic low back pain subtypes.

Author

Alshelh, Zeynab, Brusaferri, Ludovica, Saha, Atreyi, Morrissey, Erin, Knight, Paulina, Kim, Minhae, Zhang, Yi, Hooker, Jacob M, Albrecht, Daniel, Torrado-Carvajal, Angel, Placzek, Michael S, Akeju, Oluwaseun, Price, Julie, Edwards, Robert R, Lee, Jeungchan, Sclocco, Roberta, Catana, Ciprian, Napadow, Vitaly, and Loggia, Marco L

Abstract

We recently showed that patients with different chronic pain conditions (such as chronic low back pain, fibromyalgia, migraine and Gulf War illness) demonstrated elevated brain and/or spinal cord levels of the glial marker 18-kDa translocator protein (TSPO), which suggests that neuroinflammation might be a pervasive phenomenon observable across multiple aetiologically heterogeneous pain disorders. Interestingly, the spatial distribution of this neuroinflammatory signal appears to exhibit a degree of disease specificity (e.g. with respect to the involvement of the primary somatosensory cortex), suggesting that different pain conditions may exhibit distinct 'neuroinflammatory signatures'. To explore this hypothesis further, we tested whether neuroinflammatory signal can characterize putative aetiological subtypes of chronic low back pain patients based on clinical presentation. Specifically, we explored neuroinflammation in patients whose chronic low back pain either did or did not radiate to the leg (i.e. 'radicular' versus 'axial' back pain). Fifty-four patients with chronic low back pain, 26 with axial back pain [43.7 ± 16.6 years old (mean ± SD)] and 28 with radicular back pain (48.3 ± 13.2 years old), underwent PET/MRI with 11C-PBR28, a second-generation radioligand for TSPO. 11C-PBR28 signal was quantified using standardized uptake values ratio (validated against volume of distribution ratio; n = 23). Functional MRI data were collected simultaneously to the 11C-PBR28 data (i) to functionally localize the primary somatosensory cortex back and leg subregions; and (ii) to perform functional connectivity analyses (in order to investigate possible neurophysiological correlations of the neuroinflammatory signal). PET and functional MRI measures were compared across groups, cross-correlated with one another and with the severity of 'fibromyalgianess' (i.e. the degree of pain centralization, or 'nociplastic pain'). Furthermore, statistical mediation models were used to explore possible causal relationships between these three variables. For the primary somatosensory cortex representation of back/leg, 11C-PBR28 PET signal and functional connectivity to the thalamus were: (i) higher in radicular compared to axial back pain patients; (ii) positively correlated with each other; (iii) positively correlated with fibromyalgianess scores, across groups; and finally (iv) fibromyalgianess mediated the association between 11C-PBR28 PET signal and primary somatosensory cortex-thalamus connectivity across groups. Our findings support the existence of 'neuroinflammatory signatures' that are accompanied by neurophysiological changes and correlate with clinical presentation (in particular, with the degree of nociplastic pain) in chronic pain patients. These signatures may contribute to the subtyping of distinct pain syndromes and also provide information about interindividual variability in neuroimmune brain signals, within diagnostic groups, that could eventually serve as targets for mechanism-based precision medicine approaches. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Dynamic brain-to-brain concordance and behavioral mirroring as a mechanism of the patient-clinician interaction

Author

Ellingsen, Dan-Mikael, primary, Isenburg, Kylie, additional, Jung, Changjin, additional, Lee, Jeungchan, additional, Gerber, Jessica, additional, Mawla, Ishtiaq, additional, Sclocco, Roberta, additional, Jensen, Karin B., additional, Edwards, Robert R., additional, Kelley, John M., additional, Kirsch, Irving, additional, Kaptchuk, Ted J., additional, and Napadow, Vitaly, additional

Published
2020
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44. SPARC: Respiratory‐Gated Transcutaneous Vagus Nerve Stimulation Modulates Gastric Function in Functional Dyspepsia

Author

Sclocco, Roberta, primary, Nguyen, Christopher, additional, Staley, Rowan, additional, Fisher, Harrison P., additional, Velez, Christopher, additional, Mendez, April, additional, Lu, Kun-Han, additional, Liu, Zhongming, additional, Ward, Matthew P., additional, Powley, Terry, additional, Kettner, Norman W., additional, Kuo, Braden, additional, and Napadow, Vitaly, additional

Published
2020
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48. The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study

Author

Sclocco, Roberta, primary, Garcia, Ronald G., additional, Kettner, Norman W., additional, Isenburg, Kylie, additional, Fisher, Harrison P., additional, Hubbard, Catherine S., additional, Ay, Ilknur, additional, Polimeni, Jonathan R., additional, Goldstein, Jill, additional, Makris, Nikos, additional, Toschi, Nicola, additional, Barbieri, Riccardo, additional, and Napadow, Vitaly, additional

Published
2019
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