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1. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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2. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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3. Worldwide Effects of Coronavirus Disease Pandemic on Tuberculosis Services, January-April 2020

Author

Migliori, Giovanni Battista, Thong, Pei Min, Akkerman, Onno, Alffenaar, Jan-Willem, Alvarez-Navascues, Fernando, Assao-Neino, Mourtala Mohamed, Bernard, Pascale Valerie, Biala, Joshua Sorba, Blanc, Francois-Xavier, Bogorodskaya, Elena M., Borisov, Sergey, Buonsenso, Danilo, Calnan, Marianne, Castellotti, Paola Francesca, Centis, Rosella, Chakaya, Jeremiah Muhwa, Cho, Jin-Gun, Codecasa, Luigi Ruffo, D'Ambrosio, Lia, Denholm, Justin, Enwerem, Martin, Ferrarese, Maurizio, Galvao, Tatiana, Garcia-Clemente, Maria, Garcia-Garcia, Jose-Maria, Gualano, Gina, Gullon-Blanco, Jose Antonio, Inwentarz, Sandra, Ippolito, Giuseppe, Kunst, Heinke, Maryandyshev, Andrei, Melazzini, Mario, Mello, Fernanda Carvalho de Queiroz, Munoz-Torrico, Marcela, Njungfiyini, Patrick Bung, Palmero, Domingo Juan, Palmieri, Fabrizio, Piccioni, Pavilio, Piubello, Alberto, Rendon, Adrian, Sabria, Josefina, Saporiti, Matteo, Scognamiglio, Paola, Sharma, Samridhi, Silva, Denise Rossato, Souleymane, Mahamadou Bassirou, Spanevello, Antonio, Tabernero, Eva, Tadolini, Marina, Tchangou, Michel Eke, Thornton, Alice Boi Yatta, Tiberi, Simon, Udwadia, Zarir F., Sotgiu, Giovanni, Ong, Catherine Wei Min, and Goletti, Delia

Subjects
Ambulatory care facilities -- Statistics -- Safety and security measures -- International aspects, Tuberculosis -- Statistics -- Care and treatment -- International aspects, COVID-19 -- International aspects -- Influence, Health
Abstract

The coronavirus disease (COVID-19) pandemic has affected clinical management of tuberculosis (TB) and TB-related services (2,2). Reports of the first cohorts of patients with COVID-19 and TB have been recently [...]

Published
2020
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6. Reporting delays of chikungunya cases during the 2017 outbreak in Lazio region, Italy

Author

Manica, Mattia, primary, Marini, Giovanni, additional, Solimini, Angelo, additional, Guzzetta, Giorgio, additional, Poletti, Piero, additional, Scognamiglio, Paola, additional, Virgillito, Chiara, additional, della Torre, Alessandra, additional, Merler, Stefano, additional, Rosà, Roberto, additional, Vairo, Francesco, additional, and Caputo, Beniamino, additional

Published
2023
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7. How habitat factors affect an Aedes mosquitoes driven outbreak at temperate latitudes: The case of the Chikungunya virus in Italy

Author

Solimini, Angelo, primary, Virgillito, Chiara, additional, Manica, Mattia, additional, Poletti, Piero, additional, Guzzetta, Giorgio, additional, Marini, Giovanni, additional, Rosà, Roberto, additional, Filipponi, Federico, additional, Scognamiglio, Paola, additional, Vairo, Francesco, additional, and Caputo, Beniamino, additional

Published
2023
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9. Outbreaks of autochthonous Dengue in Lazio region, Italy, August to September 2023: preliminary investigation.

Author

De Carli, Gabriella, Carletti, Fabrizio, Spaziante, Martina, Maria Gruber, Cesare Ernesto, Rueca, Martina, Spezia, Pietro Giorgio, Vantaggio, Valentina, Barca, Alessandra, De Liberato, Claudio, Romiti, Federico, Scicluna, Maria Teresa, Vaglio, Stefania, Feccia, Mariano, Di Rosa, Enrico, Gianzi, Francesco Paolo, Giambi, Cristina, Scognamiglio, Paola, Nicastri, Emanuele, Girardi, Enrico, and Maggi, Fabrizio

Published
2023
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10. Genomic and Epidemiologic Surveillance of SARS-CoV-2 in the Pandemic Period: Sequencing Network of the Lazio Region, Italy.

Author

Rueca, Martina, Berno, Giulia, Agresta, Alessandro, Spaziante, Martina, Gruber, Cesare Ernesto Maria, Fabeni, Lavinia, Giombini, Emanuela, Butera, Ornella, Barca, Alessandra, Scognamiglio, Paola, Girardi, Enrico, Maggi, Fabrizio, Valli, Maria Beatrice, and Vairo, Francesco

Subjects
COVID-19 pandemic, PUBLIC health surveillance, COVID-19, INFECTIOUS disease transmission, NUCLEOTIDE sequencing, GENOMICS
Abstract

Since the beginning of the COVID-19 pandemic, large-scale genomic sequencing has immediately pointed out that SARS-CoV-2 has rapidly mutated during the course of the pandemic, resulting in the emergence of variants with a public health impact. In this context, strictly monitoring the circulating strains via NGS has proven to be crucial for the early identification of new emerging variants and the study of the genomic evolution and transmission of SARS-CoV-2. Following national and international guidelines, the Lazio region has created a sequencing laboratory network (WGSnet-Lazio) that works in synergy with the reference center for epidemiological surveillance (SERESMI) to monitor the circulation of SARS-CoV-2. Sequencing was carried out with the aims of characterizing outbreak transmission dynamics, performing the genomic analysis of viruses infecting specific categories of patients (i.e., immune-depressed, travelers, and people with severe symptoms) and randomly monitoring variant circulation. Here we report data emerging from sequencing activities carried out by WGSnet-Lazio (from February 2020 to October 2022) linked with epidemiological data to correlate the circulation of variants with the clinical and demographic characteristics of patients. The model of the sequencing network developed in the Lazio region proved to be a useful tool for SARS-CoV-2 surveillance and to support public health measures for epidemic containment. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Risk of parenterally transmitted hepatitis following exposure to invasive procedures in Italy: SEIEVA surveillance 2000-2021

Author

Caminada, Susanna, primary, Mele, Annamaria, additional, Ferrigno, Luigina, additional, Alfonsi, Valeria, additional, Crateri, Simonetta, additional, Iantosca, Giuseppina, additional, Sabato, Marise, additional, Tosti, Maria Elena, additional, D’Angelo, Franca, additional, Zotti, Carla, additional, Marengo, Noemi, additional, Cornio, Alessandro Roberto, additional, Russotto, Antonino, additional, Scarvaglieri, Maria Elisabetta, additional, Gallone, Angela, additional, Zoia, Irene, additional, Torchio, Pierfederico, additional, Melcarne, Lucia, additional, Castagno, Paolo, additional, Bassetti, Saveria, additional, Dama, Erika, additional, Orlandi, Silvia, additional, Busso, Stefania, additional, Andreoletti, Michela, additional, Fontana, Manuela, additional, Rametta, Stefania, additional, Cranco, Rosita, additional, Bonacina, Alessandra, additional, Lioce, Duilio, additional, Ciprioti, Rosamary, additional, Cappello, Maria Teresa, additional, Palma, Anna Maria, additional, Musso, Claudia, additional, Bussolino, Paola, additional, Smaniotto, Alessandro, additional, Ruffier, Mario, additional, Verardo, Marina, additional, Cipriani, Alessandro, additional, Cereda, Danilo, additional, Senatore, Sabrina, additional, Donadini, Annalisa, additional, Nespoli, Carla, additional, Gennati, Giorgio, additional, Piro, Antonio, additional, Vezzosi, Luigi, additional, Conca, Matteo, additional, Romani, Michela, additional, Tortorella, Franco Paolo, additional, Merlini, Paola Elvira, additional, Di Caterina, Davide, additional, Faccini, Marino, additional, Lamberti, Anna, additional, Rossetti, Eva, additional, Brugnoli, Rita, additional, Mainardi, Giulia, additional, Vezzoli, Alessandra, additional, Caso, Daniela, additional, Testa, Milena, additional, Costa, Daniela, additional, Senegaglia, Paola, additional, Spagna, Annamaria, additional, Lodola, Silvia, additional, Riboli, Simona, additional, Giompapa, Enza, additional, Roveri, Luigi Guido, additional, Guardigli, Gabriele, additional, Scalvinoni, Vanna, additional, Lombarda, Elena, additional, Gasparri, Serena, additional, Spertini, Silvia, additional, Gamper, Sabine, additional, Moretto, Giacomo, additional, Kofler, Elisabeth, additional, Ploner, Barbara, additional, Runggatscher, Verena, additional, Molinaro, Silvia, additional, Zuccali, Maria Grazia, additional, Franchini, Silvia, additional, Russo, Francesca, additional, Zanella, Francesca, additional, Ballarin, Debora, additional, Fiorito, Nahuel, additional, Zallot, Chiara, additional, Cian, Serena, additional, Bonsembiante, Erminio, additional, Mattiuzzo, Elena, additional, Munarin, Ludovica, additional, Palazzi, Barbara, additional, Sulaj, Arda, additional, Boin, Federica, additional, Carraro, Daniele, additional, Codolo, Antonella, additional, Fragapane, Marilena, additional, Formaglio, Andrea, additional, Giacobbe, Donatella, additional, Fenzi, Federica, additional, Gottardello, Lorena, additional, Cannizzo, Elisabetta, additional, Ceccon, Giulia, additional, De Stefani, Emanuela, additional, Casagrande, Paola, additional, Zotto, Alessandra Dal, additional, Zotto, Rita Dal, additional, Carlotto, Antonio, additional, Zorzi, Gemma, additional, Ivanovska, Sandra, additional, Postiglione, Chiara, additional, Colucci, Laura, additional, Rocco, Giulio, additional, Stacul, Rossana, additional, Breda, Ariella, additional, Bortolossi, Marisa, additional, Iob, Andrea, additional, Micossi, Simonetta, additional, Feltrin, Oriana, additional, Caernelos, Giuseppina, additional, Mela, Marco, additional, Frumento, Virna, additional, Opisso, Anna, additional, Cuccu, Alessandro, additional, Carpi, Antonella, additional, Giuffra, Paola, additional, Torracca, Francesca, additional, Castiglioni, Laura, additional, Mattei, Giovanna, additional, Gualanduzzi, Claudio, additional, Massimiliani, Erika, additional, Rampini, Alessandra, additional, Paglioli, Silvia, additional, Bisaccia, Eufemia, additional, Roversi, Sandra, additional, Resi, Davide, additional, Prengka, Anna, additional, Califano, Annalisa, additional, Santoro, Viviana, additional, Biguzzi, Emilia, additional, Reali, Chiara, additional, Morri, Michela, additional, Senatore, Daniela, additional, Balocchini, Emanuela, additional, Pierozzi, Costanza, additional, Angio, Francesco, additional, Kundisova, Lucia, additional, Isola, Alda, additional, Cecconi, Rossella, additional, Berti, Cristiana, additional, Matarazzo, Francesca, additional, Zini, Paola, additional, Staderini, Chiara, additional, Cordella, Vincenzo, additional, Brugnoli, Sara, additional, Sacchelli, Francesco, additional, Lucchesi, Lara, additional, Luzzoli, Rosa, additional, Gandolfo, Silvia, additional, Cibeca, Piero, additional, Galletti, Nicoletta, additional, Aquino, Francesco, additional, Lari, Maria, additional, Poropat, Roberta, additional, Ferrini, Rita, additional, Barbieri, Alessandro, additional, Conti, Vito, additional, Canale, Alice, additional, Moretti, Katia, additional, Buccino, Aniello, additional, Bartoli, Ilaria, additional, Cioni, Silvia, additional, Gennari, Giulia, additional, Rapaccini, Fabiola, additional, Bekshiu, Lumturi, additional, Zacchini, Federica, additional, Romani, Davide, additional, Sansone, Monica, additional, Foresi, Simona, additional, Piattellini, Giovanni, additional, Pasquale, Anna, additional, Brancaleoni, Maria Grazia, additional, Santocchia, Franco, additional, Proietti, Maria Laura, additional, Fiacchini, Daniel, additional, Giamprini, Maria Sole, additional, Iacobellis, Mariangela, additional, Van Will, Jacqueline, additional, Vaccaro, Alfredo, additional, Sbarbati, Maria Margherita, additional, Amelio, Alessandra, additional, Cimini, Daniela, additional, Moroni, Vania, additional, Francoletti, Daniela, additional, Marcellini, Mirella, additional, Scaccia, Federica, additional, Branchesi, Elisabetta, additional, Saracino, Selena, additional, Mezzanotte, Catia, additional, Cimica, Susanna, additional, Vitale, Vita, additional, Laici, Franca, additional, Petrelli, Irene, additional, Airini, Barbara, additional, Passarini, Gabriella, additional, Ruffini, Lucia, additional, Lambertucci, Anna Maria, additional, Mogetta, Annarita, additional, Ciarrocchi, Giuseppe, additional, Pistolesi, Marina, additional, Fratello, Erika, additional, Picciotti, Francesca, additional, Contrisciani, Roberta, additional, Angelini, Claudio, additional, Ribiscini, Silvia, additional, Scognamiglio, Paola, additional, Vairo, Francesco, additional, De Santis, Claudia, additional, Miglietta, Antonio Salvatore, additional, Colosi, Alberto, additional, Loffredo, Maria Rosaria, additional, Esterini, Giorgio, additional, Pendenza, Alessio, additional, Nappi, Maria Rosaria, additional, Casagni, Luca, additional, Santucci, Luigi, additional, Montecchi, Margherita, additional, Mangiagli, Franca, additional, Aquilani, Silvia, additional, Di Luzio, Giuseppe, additional, Provvidenti, Luca, additional, Giambi, Cristina, additional, Di Giacomo, Manuela, additional, Giansanti, Enrico, additional, Mancini, Cristiana, additional, Turchi, Claudio, additional, Soldato, Graziella, additional, D'Eugenio, Felesina, additional, Albanesi, Ida, additional, Montanaro, Carmen, additional, Di Giorgio, Giovanni, additional, Prozzo, Alessandra, additional, Sabatini, Paola, additional, Simonelli, Mena, additional, Morrone, Gaetano, additional, Citarella, Annarita, additional, Fossi, Elena, additional, Alfieri, Rosa, additional, Scotto, Milena, additional, Caiazzo, Anna Luisa, additional, Liquori, Antonia, additional, Chironna, Maria, additional, Prato, Rosa, additional, Martinelli, Domenico, additional, Fortunato, Francesca, additional, Cappelli, Maria Giovanna, additional, Loconsole, Daniela, additional, Morea, Anna, additional, Del Matto, Giulia, additional, Maluccio, Maria Giuseppina, additional, Pedote, Pasquale, additional, Termite, Stefano, additional, Cambria, Roberta, additional, Caputi, Giovanni, additional, Cipriani, Rosati, additional, Desiante, Francesco, additional, Menolascina, Stefania, additional, Laforgia, Vera, additional, Squicciarini, Rosella, additional, Vitale, Viviana, additional, Matera, Anna Maria, additional, Pagone, Onofrio, additional, Avella, Grazia Maria, additional, Madaro, Antonino, additional, Angelillis, Raffaele, additional, Moffa, Giuseppina, additional, Nesta, Maria, additional, De Santis, Carlo, additional, Ferraro, Marisa, additional, Aprile, Valerio, additional, Antonazzo, Marcello, additional, Laugello, Giovanni, additional, Mignuoli, Anna Domenica, additional, Afflitto, Giuseppe, additional, Caroleo, Benedetto, additional, Scrivano, Francesca, additional, Maradei, Antonio, additional, Romeo, Rocco Cataldo, additional, Zucco, Rossella, additional, Coscarelli, Pierluigi, additional, Bisbano, Alessandro, additional, Monesanti, Maria, additional, De Giorgio, Vincenzo, additional, Giordano, Antonella, additional, Mammì, Pier Domenico, additional, Lazzarino, Elisa, additional, Surace, Vittoria, additional, Mangione, Rossana, additional, Meli, Valentina, additional, Cuccia, Mario, additional, Longhitano, Elena, additional, Delogu, Fiorenzo, additional, Fracasso, Donatella, additional, Marceddu, Maria Vittoria, additional, Flore, Loredana, additional, Eugenia Marras, Maria Valentina, additional, Serpi, Rita, additional, Campus, Marco, additional, and Raggio, Alessia, additional

Published
2023
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12. Enterovirus D68-Associated Acute Flaccid Myelitis in Immunocompromised Woman, Italy

Author

Giombini, Emanuela, Rueca, Martina, Barberi, Walter, Iori, Anna Paola, Inghilleri, Maurizio, Castilletti, Concetta, Scognamiglio, Paola, Vairo, Francesco, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, and Valli, Maria Beatrice

Subjects
Myelitis -- Diagnosis -- Care and treatment -- Case studies, Enterovirus diseases -- Case studies -- Diagnosis -- Care and treatment, Health
Abstract

Enteroviruses are the most common viruses circulating worldwide and lead to a broad spectrum of clinical illnesses: respiratory infection; hand, foot, and mouth disease; acute and chronic cardiac disease; meningitis; [...]

Published
2017
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14. Impact of new DAA therapy on real clinical practice: a multicenter region-wide cohort study

Author

Lanini, Simone, Scognamiglio, Paola, Mecozzi, Alessandra, Lombardozzi, Lorella, Vullo, Vincenzo, Angelico, Mario, Gasbarrini, Antonio, Taliani, Gloria, Attili, Adolfo Francesco, Perno, Carlo Federico, De Santis, Adriano, Puro, Vincenzo, Cerqua, Fabio, D’Offizi, Gianpiero, Pellicelli, Adriano, Armignacco, Orlando, Mennini, Francesco Saverio, Siciliano, Massimo, Girardi, Enrico, Panella, Vincenzo, Ippolito, Giuseppe, and members of the Lazio Region HCV treatment group

Published
2018
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17. Air pollution, SARS-CoV-2 incidence and COVID-19 mortality in Rome: a longitudinal study

Author

Nobile, Federica, primary, Michelozzi, Paola, additional, Ancona, Carla, additional, Cappai, Giovanna, additional, Cesaroni, Giulia, additional, Davoli, Marina, additional, Di Martino, Mirko, additional, Nicastri, Emanuele, additional, Girardi, Enrico, additional, Beccacece, Alessia, additional, Scognamiglio, Paola, additional, Sorge, Chiara, additional, Vairo, Francesco, additional, and Stafoggia, Massimo, additional

Published
2022
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18. Molecular Characterization of Autochthonous Chikungunya Cluster in Latium Region, Italy

Author

Bordi, Licia, Carletti, Fabrizio, Lalle, Eleonora, Colavita, Francesca, Meschi, Silvia, Caro, Antonino Di, Nicastri, Emanuele, Scognamiglio, Paola, Vairo, Francesco, Lallo, Domenico Di, Panella, Vincenzo, Capobianchi, Maria R., Ippolito, Giuseppe, and Castilletti, Concetta

Subjects
Mosquitoes -- Health aspects, Epidemics -- Health aspects, Infection -- Health aspects, Health
Abstract

Local transmission of chikungunya virus (CHIKV) has been confirmed in the Lazio region of Italy, with 2 related autochthonous clusters in the cities of Anzio and Rome (1). This event [...]

Published
2018
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20. Hepatitis E virus genotype 4 outbreak, Italy, 2011

Author

Garbuglia, Anna R., Scognamiglio, Paola, Petrosillo, Nicola, Mastroianni, Claudio Maria, Sordillo, Pasquale, Gentile, Daniele, La Scala, Patrizia, Girardi, Enrico, and Capobianchi, Maria R.

Subjects
Hepatitis E -- Genetic aspects -- Analysis, Swine -- Analysis, Infection -- Genetic aspects -- Analysis, Health
Abstract

Hepatitis E virus (HEV) represents the major etiologic agent of enterically transmitted, non-A, non-B hepatitis. One third of the world population is estimated to have been infected with HEV, although [...]

Published
2013
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22. Using an intravenous catheter system to prevent needlestick injury

Author

Sossai, Dimitri, Puro, Vincenzo, Chiappatoli, Luca, Dagna, Giulino, Odone, Bernardo, Polimeri, Annamaria, Ruzza, Laila, Paola, Palombo, Fuscoe, Marian Stella, and Scognamiglio, Paola

Subjects
Cross infection -- Prevention, Nosocomial infections -- Prevention, Disease transmission -- Control, Needlestick injuries -- Prevention, Nurses -- Practice -- Safety and security measures, Health, Health care industry
Abstract

Abstract Aim To identify the effect of a sharps awareness campaign and the introduction of a safety catheter device on the annual incidence of needlestick injuries between 2003 and 2007 [...]

Published
2010

23. Impact of a Nationwide Lockdown on SARS-CoV-2 Transmissibility, Italy

Author

Guzzetta, Giorgio, Riccardo, Flavia, Marziano, Valentina, Poletti, Piero, Trentini, Filippo, Bella, Antonino, Andrianou, Xanthi, del Manso, Martina, Fabiani, Massimo, Bellino, Stefania, Boros, Stefano, Mateo-Urdiales, Alberto, Vescio, Maria Fenicia, Piccioli, Andrea, Brusaferro, Silvio, Rezza, Giovanni, Pezzotti, Patrizio, Ajelli, Marco, Merler, Stefano, Castrucci, Maria Rita, Ciervo, Alessandra, D’Ancona, Fortunato (Paolo), Di Benedetto, Corrado, Filia, Antonietta, Giannitelli, Stefania, Punzo, Ornella, Rota, Maria Cristina, Siddu, Andrea, Stefanelli, Paola, Tallon, Marco, Urciuoli, Roberta, Petrucci, Antonia, Labianca, Michele, Mignuoli, Anna Domenica, D'Argenzio, Angelo, Massimiliani, Erika, Gallo, Tolinda, Scognamiglio, Paola, Sticchi, Camilla, Cereda, Danilo, Fiacchini, Daniel, Sforza, Francesco, Zuccaro, Maria Grazia, Benetollo, Pier Paolo, Tiberti, Donatella, Chironna, Maria, Palmas, Maria Antonietta, Scondotto, Salvatore, Balocchini, Emanuela, Tosti, Anna, Ruffier, Mauro, and Da Re, Filippo

Subjects
Time Factors, Epidemiology, Reproduction number, Expedited, lcsh:Medicine, COVID-19, Italy, SARS, SARS-CoV-2, coronavirus disease, lockdown, reproduction number, respiratory infections, severe acute respiratory syndrome, severe acute respiratory syndrome coronavirus 2, transmissibility, viruses, zoonoses, Communicable Disease Control, Humans, Public Health, Impact of a Nationwide Lockdown on SARS-CoV-2 Transmissibility, Italy, Medical and Health Sciences, 0302 clinical medicine, Zoonoses, Medicine, Severe acute respiratory syndrome coronavirus 2, 030212 general & internal medicine, Dispatch, Transmissibility (vibration), 3. Good health, Coronavirus disease, Infectious Diseases, Severe acute respiratory syndrome, Viruses, COVID-19, ITALY, SARS, SARS-COV-2, CORONAVIRUS DISEASE, LOCKDOWN, REPRODUCTION NUMBER, RESPIRATORY INFECTIONS, SEVERE ACUTE RESPIRATORY SYNDROME, SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2, TRANSMISSIBILITY, VIRUSES, ZOONOSES, COVID-19, COMMUNICABLE DISEASE CONTROL, HUMANS, ITALY, PUBLIC HEALTH, TIME FACTORS, SARS-COV-2, Microbiology (medical), 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030231 tropical medicine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Lockdown, lcsh:RC109-216, business.industry, Transmissibility, lcsh:R, Respiratory infections, Clinical Medicine, business, Coronavirus Infections, Demography
Abstract

On March 11, 2020, Italy imposed a national lockdown to curtail the spread of severe acute respiratory syndrome coronavirus 2. We estimate that, 14 days after lockdown, the net reproduction number had dropped below 1 and remained stable at »0.76 (95% CI 0.67-0.85) in all regions for >3 of the following weeks.

Published
2021

24. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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25. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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27. COVID-19 disease—Temporal analyses of complete blood count parameters over course of illness, and relationship to patient demographics and management outcomes in survivors and non-survivors: A longitudinal descriptive cohort study

Author

Lanini, Simone, primary, Montaldo, Chiara, additional, Nicastri, Emanuele, additional, Vairo, Francesco, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Scognamiglio, Paola, additional, Antinori, Andrea, additional, Puro, Vincenzo, additional, Di Caro, Antonino, additional, De Carli, Gabriella, additional, Navarra, Assunta, additional, Agresta, Alessandro, additional, Cimaglia, Claudia, additional, Palmieri, Fabrizio, additional, D’Offizi, Gianpiero, additional, Marchioni, Luisa, additional, Kobinger, Gary Pignac, additional, Maeurer, Markus, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Zumla, Alimuddin, additional, Locatelli, Franco, additional, and Ippolito, Giuseppe, additional

Published
2020
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28. A biohybrid synapse with neurotransmitter-mediated plasticity

Author

Keene, Scott T., primary, Lubrano, Claudia, additional, Kazemzadeh, Setareh, additional, Melianas, Armantas, additional, Tuchman, Yaakov, additional, Polino, Giuseppina, additional, Scognamiglio, Paola, additional, Cinà, Lucio, additional, Salleo, Alberto, additional, van de Burgt, Yoeri, additional, and Santoro, Francesca, additional

Published
2020
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30. Epidemiology of viral hepatitis in men who have sex with men in Mediterranean Europe: a region-wide sero-surveillance in Rome (Italy)

Author

Lanini, Simone, primary, Meschi, Silvia, additional, Scorzolini, Laura, additional, Adamo, Giovanna, additional, Agresta, Alessandro, additional, Marrazzo, Fabrizio, additional, Angeli, Francesco, additional, Farinella, Massimo, additional, Guarino, Carlo, additional, Barca, Alessandra, additional, Lombardozzi, Lorella, additional, Possi, Adriano, additional, Manganiello, Mirko, additional, Magrini, Patrizia, additional, Scognamiglio, Paola, additional, Puro, Vincenzo, additional, Nicastri, Emanuele, additional, Capobianchi, Maria, additional, Zumla, Alimuddin, additional, and Ippolito, Giuseppe, additional

Published
2020
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31. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Albarello, Fabrizio, primary, Pianura, Elisa, additional, Di Stefano, Federica, additional, Cristofaro, Massimo, additional, Petrone, Ada, additional, Marchioni, Luisa, additional, Palazzolo, Claudia, additional, Schininà, Vincenzo, additional, Nicastri, Emanuele, additional, Petrosillo, Nicola, additional, Campioni, Paolo, additional, Eskild, Petersen, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, Abbonizio, Maria Alessandra, additional, Agrati, Chiara, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonini, Mario, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Branca, Marta, additional, Capobianchi, Maria Rosaria, additional, Caporale, Cinzia, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Castilletti, Concetta, additional, Chiappini, Roberta, additional, Ciaralli, Carmine, additional, Colavita, Francesca, additional, Corpolongo, Angela, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, Angelis, Alessia De, additional, Angelis, Giada De, additional, Lorenzo, Rachele Di, additional, Stefano, Federica Di, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Greci, Maria Cristina, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Marani, Alessandra, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Matusali, Giulia, additional, Meschi, Silvia, additional, Montaldo, Francesco Messina Chiara, additional, Murachelli, Silvia, additional, Noto, Roberto, additional, Pallini, Emanuele, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Petrecchia, Antonella, additional, Pisciotta, Maria, additional, Pittalis, Silvia, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Rinonapoli, Gabriele, additional, Rueca, Martina, additional, Sacchi, Alessandra, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarcia, Silvana, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Vaia, Francesco, additional, Vairo, Francesco, additional, and Valli, Maria Beatrice, additional

Published
2020
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33. Full-length genome sequence of a dengue serotype 1 virus isolate from a traveler returning from Democratic Republic of Congo to Italy, July 2019

Author

Colavita, Francesca, primary, Vairo, Francesco, additional, Carletti, Fabrizio, additional, Boccardo, Chiara, additional, Ferraro, Federica, additional, Iaiani, Giancarlo, additional, Al Moghazi, Samir, additional, Galardo, Gioacchino, additional, Lalle, Eleonora, additional, Selvaggi, Carla, additional, Scognamiglio, Paola, additional, Capobianchi, Maria Rosaria, additional, Ippolito, Giuseppe, additional, and Castilletti, Concetta, additional

Published
2020
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34. Synthesis and characterization of PEDOT-PEGDA blends for bioelectronic applications: surface properties and effects on cell morphology

Author

Polino, Giuseppina, primary, Lubrano, Claudia, additional, Scognamiglio, Paola, additional, Mollo, Valentina, additional, De Martino, Selene, additional, Ciccone, Giuseppe, additional, Matino, Laura, additional, Langella, Angela, additional, Netti, Paolo, additional, Di Carlo, Aldo, additional, Brunetti, Francesca, additional, and Santoro, Francesca, additional

Published
2020
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38. A biohybrid synapse with neurotransmitter-mediated plasticity

Author

Keene, Scott T., Lubrano, Claudia, Kazemzadeh, Setareh, Melianas, Armantas, Tuchman, Yaakov, Polino, Giuseppina, Scognamiglio, Paola, Cinà, Lucio, Salleo, Alberto, van de Burgt, Yoeri B., Santoro, Francesca, Keene, Scott T., Lubrano, Claudia, Kazemzadeh, Setareh, Melianas, Armantas, Tuchman, Yaakov, Polino, Giuseppina, Scognamiglio, Paola, Cinà, Lucio, Salleo, Alberto, van de Burgt, Yoeri B., and Santoro, Francesca

Abstract

Brain-inspired computing paradigms have led to substantial advances in the automation of visual and linguistic tasks by emulating the distributed information processing of biological systems1. The similarity between artificial neural networks (ANNs) and biological systems has inspired ANN implementation in biomedical interfaces including prosthetics2 and brain-machine interfaces3. While promising, these implementations rely on software to run ANN algorithms. Ultimately, it is desirable to build hardware ANNs4,5 that can both directly interface with living tissue and adapt based on biofeedback6,7. The first essential step towards biologically integrated neuromorphic systems is to achieve synaptic conditioning based on biochemical signalling activity. Here, we directly couple an organic neuromorphic device with dopaminergic cells to constitute a biohybrid synapse with neurotransmitter-mediated synaptic plasticity. By mimicking the dopamine recycling machinery of the synaptic cleft, we demonstrate both long-term conditioning and recovery of the synaptic weight, paving the way towards combining artificial neuromorphic systems with biological neural networks.

Published
2020

39. Effects of age and hypertension on adrenoceptor-sensitivity evaluated with CD25 and QT QS2

Author

De Caprio, Lorenzo, Di Palma, Annalisa, De Rosa, Maria Leonarda, Lirato, Carmela, Canonico, Vincenzo, Giordano, Arturo, Scognamiglio, Paola, and Rengo, Franco

Subjects
Hypertension -- Research, Beta adrenoceptors -- Research, Heart -- Contraction, Health, Seniors
Abstract

Examination of patients with hypertension and normal tension reveals the variation of chronotropic dose (CD25) with age in all subjects, while the age-dependence of the ratio of electrical systole (QT) to electromechanical systole (QS2) occurs only in normotensive subjects. Patients above 60 years show no change in beta-adrenoceptor sensitivity, while hypertensives under 60 years exhibit lower sensitivity than normotensives below 60 years. Further analyses reveal the independence of the QT QS2 ratio over beta adrenergic sensitivity.

Published
1995

42. Determinants of access to experimental antiretroviral drugs in an Italian cohort of patients with HIV: a multilevel analysis

Author

Girardi Enrico, Scognamiglio Paola, Angeletti Claudio, Gori Andrea, Buonfrate Dora, Arlotti Massimo, Mazzarello Giovanni, Castagna Antonella, Andreoni Massimo, d'Arminio Monforte Antonella, Antinori Andrea, and Ippolito Giuseppe

Subjects
antiretroviral therapy, experimental drug, HIV, cohort study, clinical trial, expanded access program, multilevel analysis, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Identification of the determinants of access to investigational drugs is important to promote equity and scientific validity in clinical research. We aimed to analyze factors associated with the use of experimental antiretrovirals in Italy. Methods We studied participants in the Italian Cohort of Antiretroviral-Naive Patients (ICoNA). All patients 18 years or older who had started cART (≥ 3 drugs including at least two NRTI) after their enrolment and during 1997-2007 were included in this analysis. We performed a random effect logistic regression analysis to take into account clustering observations within clinical units. The outcome variable was the use of an experimental antiretroviral, defined as an antiretroviral started before commercial availability, in any episode of therapy initiation/change. Use of an experimental antiretroviral obtained through a clinical trial or an expanded access program (EAP) was also analyzed separately. Results A total of 9,441 episodes of therapy initiation/change were analyzed in 3,752 patients. 392 episodes (360 patients) involved an experimental antiretroviral. In multivariable analysis, factors associated with the overall use of experimental antiretrovirals were: number of experienced drugs (≥ 8 drugs versus "naive": adjusted odds ratio [AOR] = 3.71) or failed antiretrovirals(3-4 drugs and ≥ 5 drugs versus 0-2 drugs: AOR = 1.42 and 2.38 respectively); calendar year (AOR = 0.80 per year) and plasma HIV-RNA copies/ml at therapy change (≥ 4 log versus < 2 log: AOR = 1.55). The probability of taking an experimental antiretroviral through a trial was significantly lower for patients suffering from liver co-morbidity(AOR = 0.65) and for those who experienced 3-4 drugs (vs naive) (AOR = 0.55), while it increased for multi-treated patients(AOR = 2.60). The probability to start an experimental antiretroviral trough an EAP progressively increased with the increasing number of experienced and of failed drugs and also increased for patients with liver co-morbidity (AOR = 1.44; p = 0.053). and for male homosexuals (vs heterosexuals: AOR = 1.67). Variability of the random effect associated to clinical units was statistically significant (p < 0.001) although no association was found with specific characteristics of clinical unit examined. Conclusions Among patients with HIV infection in Italy, access to experimental antiretrovirals seems to be influenced mainly by exhaustion of treatment options and not by socio-demographic factors.

Published
2012
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44. Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs

Author

Elia Paola, Giuliani Massimo, Bardacci Stefano, Selleri Marina, Ceccherini-Silberstein Francesca, Ciccozzi Massimo, D'Arrigo Roberta, Gori Caterina, Svicher Valentina, Alteri Claudia, Scognamiglio Paola, Balzano Roberta, Orchi Nicoletta, Girardi Enrico, and Perno Carlo

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background The transmission of HIV-1 drug-resistant strains in drug naive patients may seriously compromise the efficacy of a first-line antiretroviral treatment. To better define this problem, a study in a cohort of newly diagnosed HIV-1 infected individuals has been conducted. This study is aimed to assess the prevalence and the patterns of the mutations recently associated with transmitted drug resistance in the reverse transcriptase (RT) and in protease (PR) of HIV-1. Methods Prevalence of transmitted drug resistant strains is determined in 255 newly diagnosed HIV-1 infected patients enrolled in different counselling and testing (CT) centres in Central Italy; the Avidity Index (AI) on the first available serum sample is also used to estimate time since infection. Logistic regression models are used to determine factors associated with infection by drug resistant HIV-1 strains. Results The prevalence of HIV-1 strains with at least one major drug resistance mutation is 5.9% (15/255); moreover, 3.9% (10/255) of patients is infected with HIV nucleoside reverse transcriptase inhibitor (NRTI)-resistant viruses, 3.5% (9/255) with HIV non-NRTI-resistant viruses and 0.4% (1/255) with HIV protease inhibitor (PI)-resistant viruses. Most importantly, almost half (60.0%) of patients carries HIV-1 resistant strains with more than one major drug resistance mutation. In addition, patients who had acquired HIV through homosexual intercourses are more likely to harbour a virus with at least one primary resistance mutation (OR 7.7; 95% CI: 1.7–35.0, P = 0.008). Conclusion The prevalence of drug resistant HIV-1 strains among newly diagnosed individuals in Central Italy is consistent with the data from other European countries. Nevertheless, the presence of drug-resistance HIV-1 mutations in complex patterns highlights an additional potential risk for public health and strongly supports the extension of wide genotyping to newly diagnosed HIV-1 infected patients.

Published
2009
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45. Lack of implementation of Hepatitis B Virus (HBV) vaccination policy in household contacts of HBV carriers in Italy

Author

Scognamiglio Paola, Girardi Enrico, Fusco Mario, Piselli Pierluca, Spena Silvana, Maione Carmela, Pisanti Francesco, and Serraino Diego

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In Italy, HBV vaccination is recommended and offered free of charge through the National Health Service to selected population groups – e.g., family members of an HBsAg carrier, healthcare workers, newborns and those who were 12-years old in 1991. However, a significant proportion of cases of acute hepatitis B still occur in Italy among persons who should have been vaccinated. We analysed HBV sero-prevalence data of two vaccination target populations (people born after 1980 and household contacts of an HBV carrier) living in a southern Italian area in order to evaluate HBV vaccine coverage and its possible determinants. Methods Between 2003 and 2006, we carried out a cross-sectional, population-based, sero-epidemiological survey on HBV infection on 4496 randomly selected individuals (aged 20 years or more) from the general population of the province of Naples. Sera were tested for antibodies to hepatitis B core antigen (anti-HBc) and to hepatitis B surface antigen (anti-HBsAg) by commercial immunoassays. Prevalence of past or current HBV infection and of HBV vaccination-induced immunity was calculated in two vaccination target populations. To analyze the association of epidemiological and socioeconomic characteristics with HBV vaccination of household contacts, we calculated crude and multiple logistic regression (MLR) odds ratio (OR). Results Prevalence of HBV vaccine-induced immunity (anti-HBs alone) was much lower among household contacts (25%) than among those who had been targeted for universal adolescent vaccination (81.6%). Male sex, older age, unemployment and lower education levels were associated to lower immunization rates. Conclusion Understanding the different uptake of hepatitis B vaccination in these populations may provide useful information for optimizing vaccination campaigns in other contexts. Our data clearly demonstrated the need of improving the uptake of vaccination for household contacts of HBV carriers.

Published
2009
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46. Hepatitis C virus infection and risk of liver-related and non-liver-related deaths: a population-based cohort study in Naples, southern Italy.

Author

Piselli, Pierluca, Serraino, Diego, Fusco, Mario, Girardi, Enrico, Pirozzi, Angelo, Toffolutti, Federica, Cimaglia, Claudia, Taborelli, Martina, on behalf of the Collaborating Study Group, Capobianchi, Mariarosaria, Carletti, Fabrizio, Garbuglia, Anna R., Ippolito, Giuseppe, Scognamiglio, Paola, Di Cicco, Pietro, Gigli, Letizia, Russospena, Silvana, Palombino, Raffaele, Panato, Chiara, and Mattioli, Veronica

Subjects
HEPATITIS C virus, VIRUS diseases, COHORT analysis, CAUSES of death, MORTALITY, INFECTION
Abstract

Background: Hepatitis C virus (HCV) infection represents a global health issue with severe implications on morbidity and mortality. This study aimed to evaluate the impact of HCV infection on all-cause, liver-related, and non-liver-related mortality in a population living in an area with a high prevalence of HCV infection before the advent of Direct-Acting Antiviral (DAA) therapies, and to identify factors associated with cause-specific mortality among HCV-infected individuals.Methods: We conducted a cohort study on 4492 individuals enrolled between 2003 and 2006 in a population-based seroprevalence survey on viral hepatitis infections in the province of Naples, southern Italy. Study participants provided serum for antibodies to HCV (anti-HCV) and HCV RNA testing. Information on vital status to December 2017 and cause of death were retrieved through record-linkage with the mortality database. Hazard ratios (HRs) for cause-specific mortality and 95% confidence intervals (CIs) were estimated using Fine-Grey regression models.Results: Out of 626 deceased people, 20 (3.2%) died from non-natural causes, 56 (8.9%) from liver-related conditions, 550 (87.9%) from non-liver-related causes. Anti-HCV positive people were at higher risk of death from all causes (HR = 1.38, 95% CI: 1.12-1.70) and liver-related causes (HR = 5.90, 95% CI: 3.00-11.59) than anti-HCV negative ones. Individuals with chronic HCV infection reported an elevated risk of death due to liver-related conditions (HR = 6.61, 95% CI: 3.29-13.27) and to any cause (HR = 1.51, 95% CI: 1.18-1.94). The death risk of anti-HCV seropositive people with negative HCV RNA was similar to that of anti-HCV seronegative ones. Among anti-HCV positive people, liver-related mortality was associated with a high FIB-4 index score (HR = 39.96, 95% CI: 4.73-337.54).Conclusions: These findings show the detrimental impact of HCV infection on all-cause mortality and, particularly, liver-related mortality. This effect emerged among individuals with chronic infection while those with cleared infection had the same risk of uninfected ones. These results underline the need to identify through screening all people with chronic HCV infection notably in areas with a high prevalence of HCV infection, and promptly provide them with DAAs treatment to achieve progressive HCV elimination and reduce HCV-related mortality. [ABSTRACT FROM AUTHOR]

Published
2021
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47. People living with undiagnosed HIV infection and a low CD4 count: Estimates from surveillance data, Italy, 2012 to 2014

Author

Regine, Vincenza, Dorrucci, Maria, Pezzotti, Patrizio, Mammone, Alessia, Quinten, Chantal, Pharris, Anastasia, Suligoi, Barbara, Di Giacomo, Manuela, Faggioni, Viviana, Scancella, Luigi, Locuratolo, Francesco, Cauzillo, Gabriella, Mignuoli, Anna Domenica, Chirico, Daniele Giuseppe, Borgia, Guglielmo, Massimiliani, Erika, Gallo, Tolinda, Braida, Cinzia, Puro, Vincenzo, Scognamiglio, Paola, Icardi, Giancarlo, Lai, Piero Luigi, Gramegna, Maria, Coppola, Liliana, Piatti, Alessandra, Rosa, Annamaria, Cereda, Danilo, Filippetti, Fabio, Prozzo, Alessandra, Pasqualini, Chiara, Mian, Peter, Moling, Oswald, Pagani, Leonardo, Lanzafame, Paolo, Collini, Lucia, Bassetti, Danila, Chironna, Maria, Palmas, Maria Antonietta, Dardanoni, Gabriella, Voller, Fabio, Puglia, Monia, Pecori, Lucia, Tosti, Anna, Papili, Rita, Ruffier, Mauro, Verardo, Marina Giulia, Echarlod, Elisa Francesca, Amoroso, Saveria, Russo, Francesca, and Da Re, Filippo

Subjects
Adult, Male, 0301 basic medicine, Surveillance data, Epidemiology, HIV diagnosis, Prevalence, Human immunodeficiency virus (HIV), HIV Infections, surveillance data, medicine.disease_cause, modelling, Sexual and Gender Minorities, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Virology, Humans, Medicine, 030212 general & internal medicine, Heterosexuality, Hiv transmission, Disease Notification, Hiv surveillance, business.industry, low CD4 count, Environmental and Occupational Health, Public Health, Environmental and Occupational Health, virus diseases, Middle Aged, HIV infection, 030112 virology, Confidence interval, undiagnosed HIV infection, CD4 Lymphocyte Count, Italy, Population Surveillance, Epidemiological Monitoring, Female, Disease prevention, Public Health, business, Research Article, Demography
Abstract

Background and aims Late HIV diagnosis is associated with onward HIV transmission, higher morbidity, mortality and healthcare costs. In Italy, more than half of people living with HIV were diagnosed late during the last decade, with a CD4 count 3 at diagnosis. We aimed to determine the number and characteristics of people living with undiagnosed HIV infection and low CD4 counts in Italy. Methods: Data on newly reported HIV diagnoses from 2012 –2014 were obtained from the national HIV surveillance system. We used the European Centre for Disease Prevention and Control HIV modelling tool to calculate the undiagnosed prevalence and yearly diagnosed fraction (YDF) in people with low CD4 count. Results: The estimated annual number undiagnosed HIV infections with low CD4 count was on average 6,028 (95% confidence interval (CI): 4,954–8,043) from 2012–2014. In 2014, most of the undiagnosed people with low CD4 count were men (82.8%), a third acquired HIV through sex between men (MSM) (35.0%), and heterosexual transmission (33.4%), respectively. The prevalence of undiagnosed HIV infection was 11.3 (95% CI: 9.3–14.9) per 100,000 residents ranging from 0.7 to 20.8 between Italian regions. Nationally the prevalence rate was 280.4 (95% CI: 173.3–450.2) per 100,000 MSM, 8.3 (95% CI: 4.9–13.6) per 100,000 heterosexual men, and 3.0 (95% CI: 1.4–5.6) per 100,000 women. The YDF was highest among heterosexual women (27.1%; 95% CI: 16.9–45.2%). Conclusions: These findings highlight the importance of improving efforts to identify undiagnosed HIV infections primarily among men, both MSM and heterosexual men.

Published
2018

48. Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Author

Abbonizio, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vita, Serena, Di Bari, Virginia, Goletti, Delia, Espinosa, Joaquin, Petracca, Sebastiano, and Palmieri, Fabrizio

Published
2021
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50. Epidemiology of Viral Hepatitis in Men Who Have Sex with Men in Mediterranean Europe: A Region-Wide Sero-Surveillance in Rome (Italy)

Author

Lanini, Simone, primary, Meschi, Silvia, additional, Scorzolini, Laura, additional, Adamo, Giovanna, additional, Agresta, Alessandro, additional, Marrazzo, Fabrizio, additional, Angeli, Francesco, additional, Farinella, Massimo, additional, Guarino, Carlo, additional, Barca, Alessandra, additional, Lombardozzi, Lorella, additional, Possi, Adriano, additional, Manganiello, Mirko, additional, Magrini, Patrizia, additional, Scognamiglio, Paola, additional, Puro, Vincenzo, additional, Nicastri, Emanuele, additional, Capobianchi, Maria Rosaria, additional, Zumla, Alimuddin, additional, Ippolito, Giuseppe, additional, and Group, PrEV Study, additional

Published
2019
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