37 results on '"Screpis D"'
Search Results
2. The use of augmented reality for limb and component alignment in total knee arthroplasty: systematic review of the literature and clinical pilot study
- Author
-
Iacono, V., Farinelli, L., Natali, S., Piovan, G., Screpis, D., Gigante, A., and Zorzi, C.
- Published
- 2021
- Full Text
- View/download PDF
3. Posterolateral Instability
- Author
-
Zorzi, C., Condello, V., Madonna, V., Piovan, G., Screpis, D., and Volpi, Piero, editor
- Published
- 2016
- Full Text
- View/download PDF
4. Autologous micro-fragmented adipose tissue for the treatment of diffuse degenerative knee osteoarthritis: an update at 3 year follow-up
- Author
-
Russo, A., Screpis, D., Di Donato, S. L., Bonetti, S., Piovan, G., and Zorzi, C.
- Published
- 2018
- Full Text
- View/download PDF
5. Simultaneous Bilateral Total Knee Arthroplasty in Elderly: Are There Factors that Can Influence Safety and Clinical Outcome?
- Author
-
Piovan, G., primary, Screpis, D., additional, Natali, S., additional, Iacono, V., additional, Baldini, M., additional, Farinelli, L., additional, Guerriero, M., additional, and Zorzi, C., additional
- Published
- 2022
- Full Text
- View/download PDF
6. A novel technique for combined medial collateral ligament and posterior oblique ligament reconstruction: technical note
- Author
-
Madonna, V., Screpis, D., Condello, V., Piovan, G., Russo, A., Guerriero, M., and Zorzi, C.
- Published
- 2015
- Full Text
- View/download PDF
7. Ricostruzione di legamento crociato anteriore con tecnica a singolo fascio con tenodesi extra-articolare laterale
- Author
-
ZAFFAGNINI, STEFANO, BONANZINGA, TOMMASO, MARCHEGGIANI MUCCIOLI, GIULIO MARIA, MARCACCI, MAURILIO, Screpis D, Neri MP, Grassi A, Musiani C, Bondi A, Raggi F, Zaffagnini S, Bonanzinga T, Screpis D, Marcheggiani Muccioli GM, Neri MP, Grassi A, Musiani C, Bondi A, Raggi F, and Marcacci M
- Subjects
tenodesi extra articolare laterale ,Ricostruzione del legamento crociato anteriore - Abstract
Ricostruzione del legamento crociato anteriore con tenodesi extra articolare laterale
- Published
- 2013
8. All-inside repair of meniscal bucket handle tears: A retrospective study at mean 4-years follow-up evaluation
- Author
-
Nobile, F., Condello, V., Madonna, V., Screpis, D. U., Di Donato, S. L., Kon, E., Marcacci, M., Berardo Di Matteo, and Zorzi, C.
9. Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up
- Author
-
Simone, Natali, Daniele, Screpis, Michele, Romeo, Stefano, Magnanelli, Giuseppe, Rovere, Amarossi, Andrea, Lawrence, Camarda, Claudio, Zorzi, Natali S., Screpis D., Romeo M., Magnanelli S., Rovere G., Andrea A., Camarda L., and Zorzi C.
- Subjects
Adipose-derived mesenchymal stem cells ,Hip osteoarthritis ,Orthopedics and Sports Medicine ,Surgery ,Autologous micro-fragmented adipose tissue - Abstract
Background Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes. Methods Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery. Results The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days. Conclusion This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results.
- Published
- 2022
- Full Text
- View/download PDF
10. Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients
- Author
-
Matteo Cadossi, Luca Cevolani, Davide Maria Donati, Francesca de Terlizzi, Giuseppe Bianchi, Enrico Bonicoli, Giovanni Ciani, Francesco Benazzo, Leo Massari, François Cornelis, Daniele Screpis, Mario Mosconi, Costantino Errani, Barbara Rossi, Flavio Fazioli, Michele Boffano, Andrea Tognù, M. Nicolosi, Paolo Spinnato, Laura Campanacci, Giancarlo Facchini, Raimondo Piana, Campanacci L., Bianchi G., Cevolani L., Errani C., Ciani G., Facchini G., Spinnato P., Tognu A., Massari L., Cornelis F.H., Mosconi M., Screpis D., Benazzo F., Rossi B., Bonicoli E., Fazioli F., Nicolosi M., Boffano M., Piana R., De Terlizzi F., Cadossi M., and Donati D.M.
- Subjects
Male ,Electrochemotherapy ,Palliative care ,Bone disease ,medicine.medical_treatment ,Bone Nails ,030218 nuclear medicine & medical imaging ,Antineoplastic Agent ,Electrochemotherapy (ECT) ,0302 clinical medicine ,Prospective Studies ,Prospective cohort study ,Pain control ,Aged, 80 and over ,Cancer Pain ,General Medicine ,Middle Aged ,Bone metastases ,Metastatic bone disease (MBD) ,Fracture Fixation, Intramedullary ,Oncology ,030220 oncology & carcinogenesis ,Disease Progression ,Female ,Radiology ,Human ,Adult ,medicine.medical_specialty ,Fractures, Spontaneou ,Antineoplastic Agents ,Bone Neoplasms ,Bone Neoplasm ,behavioral disciplines and activities ,NO ,03 medical and health sciences ,Breast cancer ,mental disorders ,medicine ,Humans ,Adverse effect ,Response Evaluation Criteria in Solid Tumors ,Aged ,Bone Nail ,business.industry ,medicine.disease ,Radiation therapy ,Bone metastase ,Prospective Studie ,Fractures, Spontaneous ,Quality of Life ,Surgery ,business ,Progressive disease - Abstract
Introduction Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions. Materials and methods 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered. Results 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5–52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0–1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up. Conclusion The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy.
- Published
- 2021
- Full Text
- View/download PDF
11. Ricostruzione di LCA con tecnica a doppio fascio non anatomico
- Author
-
MARCACCI, MAURILIO, MARCHEGGIANI MUCCIOLI, GIULIO MARIA, BONANZINGA, TOMMASO, ZAFFAGNINI, STEFANO, a. grassi, m.p. neri, d. screpis, c. musiani, m. nitri, a. scarale, Stefano Zaffagnini, Marcacci M, Marcheggiani Muccioli GM, Grassi A, Bonanzinga T, Neri MP, Screpis D, Musiani C, Nitri M, Scarale A, Zaffagnini S., m. marcacci, g. marcheggiani muccioli, a. grassi, t. bonanzinga, mp. neri, d. screpi, c. musiani, m. nitri, a. scarale, and s. zaffagnini
- Subjects
legamento crociato anteriore ,lca reconstruction ,doppio fascio - Abstract
Indice PARTE GENERALE PARTE SPECIALE - Ginocchio - Lesioni del legamento crociato anteriore - Menisco - Legamento crociato posteriore e plastiche esterne - Cartilagine - Osteotomia tibiale correttiva in associazione a ricostruzione del legamento crociato anteriore MEMBRANA SINOVIALE LA SPALLA - Instabilità della spalla: inquadramento e tecnica chirurgica - Lesioni della cuffia dei rotatori - Miscellanea GOMITO CAVIGLIA E PIEDE POLSO ANCA
- Published
- 2013
12. Simoultaneous bilateral medial opening wedge high tibial osteotomy can be performed safely and effectively without bone grafting: analysis of a monocentric retrospective series.
- Author
-
Screpis D, Baldini M, Piovan G, Santamaria F, Iacono V, Gigante A, and Zorzi C
- Subjects
- Humans, Retrospective Studies, Male, Female, Middle Aged, Treatment Outcome, Aged, Patient Satisfaction, Bone Plates, Knee Joint surgery, Knee Joint diagnostic imaging, Knee Joint physiopathology, Adult, Bone Transplantation methods, Follow-Up Studies, Osteotomy methods, Osteotomy adverse effects, Tibia surgery, Tibia diagnostic imaging, Osteoarthritis, Knee surgery
- Abstract
Background: Simultaneous bilateral high tibial osteotomy (SBHTO) is a potential solution to treat bilateral medial osteoarthritis (OA) associated with tibial varus deformity. Concerns on the potential problems related to bone healing exists, and most of the surgeon performing SBHTO use bone void filler as associated procedure. This paper aim to evaluate safety and efficacy of SBHTO using locking plate, autologous cancellous bone mobilization and no bone void filler with immediate weight bearing at tolerance protocol., Methods: Consecutive patients performing primary SBHTO between January 2019 and December 2022 were retrospectively evaluated. Functional and pain score, subjective satisfaction and complications were noted at 2, 3, 6 months and final follow up, with a minimum of 12 months., Results: A total of 40 patients (80 knees) were included. Mean correction for each limb was 8.67° ± 2.24°. No patients presented with major complications. Pain was reduced but activity level worsened 2 months after surgery. All pain and functional scores improved significantly from months 3 up to final follow up. 95% of patients reported to be subjectively satisfied with surgery., Conclusions: This paper showed that SBHTO can be performed safely and with good results without bone grafting the osteotomy gap, even for correction up to 12°. Pain improved already 2 months after surgery, while activity level and function start to improve at 3 months after surgery., Level of Evidence: IV., Competing Interests: Declarations. Ethics approval and consent to participate: All patients gave informed consent to the use of their anonymized clinical data for the purpose of this research, according to the declaration of Helsinki. IRB of IRCCS Sacro Cuore Don Calabria gave approval to the treatment of personal data for the purpose of this research paper. (Unità per la Ricerca Clinica, IRCCS Sacro Cuore – Don Calabria, Piano Terra – Ex Palazzina, Ufficio Tecnico, Via Don A. Sempreboni, 5, 37024 Negrar di Valpolicella (VR)) Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
13. Mid-term outcomes of medial metal backed and all-polyethylene unicompartmental knee arthroplasty in obese patients: a retrospective propensity-matched analysis.
- Author
-
De Berardinis L, Piovan G, Screpis D, Senarighi M, Baldini M, Povegliano L, Gigante AP, and Zorzi C
- Subjects
- Humans, Retrospective Studies, Male, Female, Aged, Middle Aged, Treatment Outcome, Follow-Up Studies, Time Factors, Prosthesis Design, Patient Reported Outcome Measures, Arthroplasty, Replacement, Knee methods, Obesity surgery, Obesity complications, Propensity Score, Metals, Polyethylene, Knee Prosthesis
- Abstract
Background: This retrospective study compares the outcomes of unicompartmental medial fixed-bearing knee arthroplasty (mUKA), involving a cemented metal-backed (MB) or an all-polyethylene (AP) tibial component, performed in obese patients with a body mass index (BMI) > 30 with a follow-up of at least 5 years., Methods: The institutional database was mined for primary mUKAs involving an MB or an AP tibial component (MB-UKA and AP-UKA groups, respectively) performed from January 2015 to August 2019. Patient demographics and patient-reported outcome measures (PROMs) were compared and a propensity score matching (PSM) analysis (1:1) using multiple variables was conducted., Results: PSM analysis yielded 37 pairs of obese MB-UKA and AP-UKA patients. At 5 years, the Knee Society Function Score (KSFS) was 75.1 ± 10.6 in MB-UKA and 79.4 ± 9.1 in AP-UKA patients (p = 0.029), and the Oxford Knee Score (OKS) was 38.1 ± 4.4 in MB-UKA and 40.6 ± 5.7 in AP-UKA patients (p = 0.011)., Conclusion: At five-year follow-up, in a matched group of obese MB-UKA and AP-UKA patients, the AP-UKA group achieved better KSFSs and OKSs. Both the AP and the MB tibial components were able to bring about a significant improvement of the most widely used PROMs., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
14. Surgical and Biological Treatment with a Platelet-Rich Fibrin Matrix for Patellar Tendinopathy: Clinical Outcomes and Return to Sport at 2-Year Follow-Up.
- Author
-
Iacono V, Padovani L, Qordja F, De Berardinis L, Screpis D, Gigante AP, and Zorzi C
- Abstract
Background: Patellar tendinopathy (PT) involves anterior knee pain and functional. Platelet-rich fibrin matrix (PRFM) is a promising biological therapy for tendinopathies. We examined a cohort of PT patients treated with tendon debridement and autologous PRFM at the 24-month follow-up to assess whether the combined treatment facilitated return to sports and yielded satisfactory clinical and functional scores., Methods: Baseline and 24-month visual analogue scale (VAS), Victorian Institute of Sport Assessment Scale for Patellar Tendinopathy (VISA-P), Tegner Activity Scale (TAS), and Blazina scores were compared to evaluate treatment effectiveness. The Friedman test was used to compare repeated observations of VAS, VISA-P, TAS, and Blazina Score values. Return to sport rate, Tampa Scale of Kinesiophobia (TKS) score and patient satisfaction were collected at 24 months., Results: The postoperative clinical scores demonstrated significant improvement compared with their preoperative values (all p < 0.001). Specifically, the VISA-P score was 80.32 (±20.58), 92.10% of patients had resumed sports activities and patient satisfaction was 9.21 (±1.21) at 24 months., Conclusions: Surgical debridement and autologous PRFM application in patients with chronic PT resulted in a higher rate of return to sports when compared to solely surgical treatment, significantly improved clinical outcomes and excellent patient satisfaction at 24 months.
- Published
- 2024
- Full Text
- View/download PDF
15. Metal-backed or all-poly tibial components: which are better for medial unicompartmental knee arthroplasty? A propensity-score-matching retrospective study at the 5-year follow-up.
- Author
-
Piovan G, De Berardinis L, Screpis D, Senarighi M, Povegliano L, Natali S, Gigante AP, and Zorzi C
- Subjects
- Humans, Retrospective Studies, Male, Female, Aged, Follow-Up Studies, Middle Aged, Tibia surgery, Polyethylene, Treatment Outcome, Osteoarthritis, Knee surgery, Arthroplasty, Replacement, Knee methods, Propensity Score, Prosthesis Design, Knee Prosthesis, Patient Reported Outcome Measures, Metals
- Abstract
Background: This retrospective medium-term follow-up study compares the outcomes of medial fixed-bearing unicompartmental knee arthroplasty (mUKA) using a cemented metal-backed (MB) or an all-polyethylene (AP) tibial component., Materials and Methods: The database of our institution was mined for primary mUKA patients implanted with an MB or an AP tibial component (the MB-UKA and AP-UKA groups, respectively) from 2015 to 2018. We compared patient demographics, patient-reported outcome measures (PROMs), and motion analysis data obtained with the Riablo™ system (CoRehab, Trento, Italy). We conducted propensity-score-matching (PSM) analysis (1:1) using multiple variables., Results: PSM analysis yielded 77 pairs of MB-UKA and AP-UKA patients. At 5 years, the physical component summary (PCS) score was 52.4 ± 8.3 in MB-UKA and 48.2 ± 8.3 in AP-UKA patients (p < 0.001). The Forgotten Joint Score (FJS-12) was 82.9 ± 18.8 in MB-UKAs and 73.4 ± 22.5 in AP-UKAs (p = 0.015). Tibial pain was reported by 7.8% of the MB-UKA and 35.1% of the AP-UKA patients (p < 0.001). Static postural sway was, respectively, 3.9 ± 2.1 cm and 5.4 ± 2.3 (p = 0.0002), and gait symmetry was, respectively, 92.7% ± 3.7 cm and 90.4% ± 5.4 cm (p = 0.006). Patient satisfaction was 9.2 ± 0.8 in the MB-UKA and 8.3 ± 2.0 in the AP-UKA group (p < 0.003)., Conclusions: MB-UKA patients experienced significantly better 5-year static sway and gait symmetry outcomes than AP-UKA patients. Although the PROMs of the two groups overlapped, MB-UKA patients had a lower incidence of tibial pain, better FJS-12 and PCS scores, and were more satisfied., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
16. Double Vector: A Combined Biomechanical and Anatomical Posterolateral Corner Reconstruction Technique.
- Author
-
Screpis D, Santamaria F, Magnanelli S, De Berardinis L, Natali S, Gigante AP, and Zorzi C
- Abstract
Posterolateral corner (PLC) injuries are complex knee injuries that are becoming increasingly frequent. Often undiagnosed and underestimated, a systematic diagnostic workup is necessary to assess the severity of PLC injury in order to then be able to select the proper surgery approach. Anatomical and nonanatomical PLC-reconstruction techniques have been described. In this Technical Note, we describe our technique of biomechanical reconstruction of PLC in case of severe posterolateral rotational instability., Competing Interests: The authors report no conflicts of interest in the authorship and publication of this article. Full ICMJE author disclosure forms are available for this article online, as supplementary material., (© 2023 The Authors.)
- Published
- 2024
- Full Text
- View/download PDF
17. Efficacy and Long-Term Outcomes of Intra-Articular Autologous Micro-Fragmented Adipose Tissue in Individuals with Glenohumeral Osteoarthritis: A 36-Month Follow-Up Study.
- Author
-
Natali S, Screpis D, Patania E, De Berardinis L, Benoni A, Piovan G, Iacono V, Magnan B, Gigante AP, and Zorzi C
- Abstract
Background: Glenohumeral osteoarthritis (GOA) is associated with disabling shoulder pain that affects everyday life. Its management comprises various treatment approaches, both conservative and surgical. Regenerative medicine has gained a major role in the conservative treatment of osteoarthritis. Intra-articular injection of adipose-derived mesenchymal stem cells (ADMSCs) is a widely used regenerative medicine approach. The aim of this retrospective study was to report the safety and clinical outcomes of intra-articular injection of ADMSCs in patients with GOA over 36-months., Methods: This retrospective observational study involved patients with chronic shoulder pain resistant to standard conservative treatment and a diagnosis of concentric GOA, who received an intra-articular injection of autologous micro-fragmented adipose tissue (μFAT). The values of the Constant-Murley score (CMS), the visual analog scale (VAS), and the simple shoulder test (SST), collected at baseline and at 12, 24, and 36 months, were analyzed to assess treatment efficacy. The single assessment numeric evaluation (SANE) was used to rate patient satisfaction. The Friedman test was used to compare observations of CMS, VAS, and SST values repeated on the same subjects. The significance threshold was set at 0.05., Results: The participants were 65 patients with a mean age of 54.19 years and a nearly equal gender distribution. Most had mild concentric GOA classified as Samilson-Prieto grade 1. The mean follow-up duration was 44.25 months. The postoperative clinical scores showed significant improvement. At 36 months, the CMS was 84.60, the VAS score was 3.34, and the SST score was 10.15 (all p < 0.0001). The SANE score at 36 months indicated that 54 patients (83.08%) were completely satisfied with the treatment., Conclusion: ADMSC treatment exerted favorable effects on the clinical outcomes of patients with GOA, providing pain relief and improving shoulder function. Our data support its use as a conservative treatment option for osteoarthritis.
- Published
- 2023
- Full Text
- View/download PDF
18. Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? A three year follow-up.
- Author
-
Natali S, Screpis D, Romeo M, Magnanelli S, Rovere G, Andrea A, Camarda L, and Zorzi C
- Subjects
- Humans, Follow-Up Studies, Transplantation, Autologous methods, Injections, Intra-Articular methods, Adipose Tissue, Treatment Outcome, Osteoarthritis, Hip surgery, Osteoarthritis, Knee surgery
- Abstract
Background: Recently, increased attention on regenerative medicine and biological injective treatments have been proposed to restore native cartilage. Micro-fragmented adipose tissue (MFAT) has been studied for its anti-inflammatory, paracrine, and immunomodulatory effects. The long-term effects of MFAT are still poorly understood: the aim of the present study is to demonstrate how hip articular injections with autologous MFAT can have an impact on clinical outcomes., Methods: Seventy-one consecutive patients affected by early hip osteoarthritis underwent an ultrasound-guided hip injection of autologous MFAT between June 2017 and December 2018. Patients were divided into four groups according to the Oxford Hip Score. All patients received 4 mL of autologous micro-fragmented adipose tissue under an ultrasound guide. A clinical evaluation was done between 29 and 41 months after the initial treatment. During this follow-up period, we recorded any new treatment the patients had done, whether that be injection or arthroplasty surgery., Results: The study included 55 patients. Out of 55 patients, 28 saw benefits and were in no need of further treatment. Moreover, the score between the beginning and control increased by 6.9 points. Ten patients underwent a new articular injection: the mean time between the two injections was 635.7 ± 180 days. Seventeen patients underwent total hip replacement: the mean period between the autologous MFAT injection and the surgery was 495 days., Conclusion: This study found that intra-articular injections with autologous MFAT achieve beneficial clinical results in patients affected by early to moderate hip osteoarthritis, with an OHS between 48 and 30. Furthermore, these subjects are the ideal patients for whom this treatment obtains good clinical results., (© 2022. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
19. Return to Sports and Functional Outcomes after Autologous Platelet-Rich Fibrin Matrix (PRFM) and Debridement in Midportion Achilles Tendinopathy: A Case Series with 24-Month Follow-Up.
- Author
-
Iacono V, Natali S, De Berardinis L, Screpis D, Gigante AP, and Zorzi C
- Abstract
(1) Background: Achilles tendinopathy (AT) is characterized by load-induced tendon pain, stiffness, and functional impairment that may affect the tendon midportion or insertion. Platelet-rich fibrin matrix (PRFM) is a promising adjunctive therapy for AT. We analyzed 24-month pain and functional outcomes in a cohort of patients managed by tendon debridement and autologous PRFM application to determine whether the combined treatment ensured an early return to sports/work and satisfactory clinical outcomes and functional scores. (2) Methods: The 24-month outcomes of 32 sport-practicing patients with chronic midportion AT treated with debridement and autologous PRFM were evaluated in terms of time to return to sports/work. The AOFAS and VISA-A were computed preoperatively and at 6 and 24 months. Blazina scores were evaluated preoperatively and at 6 months; ankle range of motion was assessed at 1, 6, 12, 24 months; and patient satisfaction was assessed at 24 months. (3) Results: Altogether, all patients had resumed their sport(s) activity, at the same or higher level, after 25.41 days (±5.37). Regarding work, all patients were able to return to their jobs after 16.41 days (±2.43). Ankle dorsiflexion and plantarflexion increased significantly: the AOFAS rose from 54.56 (±6.47) to 97.06 (±4.06) and 98.88 (±2.21) at 6 and 12 months, respectively, and the mean VISA-A score rose from 69.16 (±7.35) preoperatively to 95.03 (±4.67) and 97.28 (±2.43) at 6 and 12 months, respectively, after treatment. There were no complications. Most (90.62%) patients were very satisfied. (4) Conclusions: In symptomatic midportion AT, surgical debridement and autologous PRFM ensured a fast return to sports/work (4 weeks), significantly improving AOFAS and VISA-A and Blazina scores already at 6 months and providing excellent clinical outcomes at 24 months.
- Published
- 2023
- Full Text
- View/download PDF
20. Anatomic Combined Anterior Cruciate Ligament and Antero-Lateral Ligament Reconstruction Using Autologous Gracilis and Semitendinosus Graft With Single Tibial and Femoral Tunnel.
- Author
-
Screpis D, Baldini M, Magnanelli S, Amarossi A, Piovan G, Natali S, and Zorzi C
- Abstract
Anterior cruciate ligament (ACL) injuries are among the most common lesions in orthopaedics practice, but still today, rates up to 24% of unsatisfactory results are reported. Unaddressed anterolateral complex (ALC) injuries have been claimed to be responsible for residual anterolateral rotatory instability (ALRI) after isolate ACL reconstruction and have demonstrated to increase graft failure. In this article, we present our technique for reconstruction of the ACL and anterolateral (ALL) ligament combining the advantages of the anatomical position and the intraosseous femoral fixation to ensure anteroposterior and anterolateral rotational stability., (© 2022 The Authors.)
- Published
- 2023
- Full Text
- View/download PDF
21. The role of antibiotic calcium sulfate beads in acute periprosthetic knee infection: a retrospective cohort study.
- Author
-
Piovan G, Farinelli L, Screpis D, Marocco S, Motta L, Palazzolo G, Natali S, and Zorzi C
- Abstract
Background: The study aimed to compare debridement, antibiotics, and implant retention (DAIR) vs. debridement antibiotic bead and retention of the implant (DABRI) in terms of infection-free success rate and treatment cost for acute periprosthetic joint infections after total knee arthroplasty (TKA)., Method: Between 2017 and 2020, 32 patients with acute periprosthetic joint infection who were treated by total knee arthroplasty were retrospectively reviewed. The patients were divided into a DAIR group (n=15) and a DABRI group (n=17). During the DABRI, additional calcium ulphate antibiotic beads were used. Patient age, the Musculoskeletal Infection Society score, microorganisms involved, and success rate were assessed., Results: The mean age of DAIR group (n=15) was 69 years, with 7 being male, and 8 female. The mean follow-up period lasted 30 months. The success rate was 80% (12/15). The mean age of DABRI group (n=17) was 64 years, with 10 patients being male and 7 female. The mean follow-up period was 16 months. The success rate was 88% (15/17). There were no significant differences in patient age (P>0.05), the Musculoskeletal Infection Society score (P>0.05), and success rate (P>0.05). A significant difference was found in the follow-up period between the two groups (P<0.05)., Conclusion: Both DAIR and DABRI could be used to treat acute periprosthetic joint infections and the outcomes and treatment costs of the two procedures were comparable. Additional use of calcium sulfate beads was safe, but might not improve the treatment result. Randomized controlled studies are warranted for the routine use., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
22. Distal femoral osteotomy versus lateral unicompartmental arthroplasty for isolated lateral tibiofemoral osteoarthritis with intra-articular and extra-articular deformity: a propensity score-matched analysis.
- Author
-
Piovan G, Farinelli L, Screpis D, Iacono V, Povegliano L, Bonomo M, Auregli L, and Zorzi C
- Abstract
Purpose: Lateral unicompartmental arthroplasty (UKA) and distal femoral osteotomy (DFO) represent surgical solutions in cases of valgus malalignment and isolated lateral osteoarthritis (OA) of the knee. The aim of the present study was to assess the clinical results, complications, and the overall postoperative alignment of a series of DFO and lateral UKA with a minimum 2-year follow-up in active middle-aged patients., Methods: Patients with valgus knee and isolated lateral OA who underwent opening-wedge DFO or UKA from 2017 to 2019 were reviewed. Each patient was characterized by a joint line convergence angle (JLCA) > 3° and mechanical lateral distal femoral angle (mLDFA) < 87°. We excluded patients who underwent meniscus or osteochondral allograft during DFO. The Oxford Knee Score (OKS), Knee Injury and Osteoarthritis Outcome Score (KOOS), complications, and postoperative alignment were assessed. Propensity score matching was used to identify comparable patients., Results: The DFO and lateral UKA groups consisted of 29 patients each. No statistically significant differences in gender, age, body mass index (BMI), length of follow-up, or limb deformity were reported between the two groups. In the DFO group, OKS was reported to improve from 27.51 to 38.59 (p < 0.05) and KOOS from 51.14 to 67.2 (p < 0.05). Similarly, in the UKA group, OKS improved from 26.23 to 35.43 (p < 0.05) and KOOS from 50.12 to 65.91 (p < 0.05). However, the improvement in OKS and KOOS (delta) did not differ between groups (p = 0.35 and p = 0.95). The DFO and UKA groups were characterized by similar postoperative hip-knee-ankle (HKA) angle measurements of -3.26 and -3.00, respectively (p = 0.65). No patients in the UKA group underwent revision or other knee surgeries during follow-up. No infections were detected in either group. In the DFO group, no cases of nonunion or delayed union were reported. However, 40% of DFO patients underwent plate removal. One patient in each group was characterized by progression of medial OA with Kellgren-Lawrence (KL) grade > 3., Conclusion: UKA and DFO represent an effective treatment in lateral knee OA with intra-articular and extra-articular deformity. Both surgeries were able to provide a significant and comparable clinical improvement., Level of Evidence: III, comparative retrospective cohort study., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
23. Human Amniotic Suspension Allograft Improves Pain and Function in Knee Osteoarthritis: A Prospective Not Randomized Clinical Pilot Study.
- Author
-
Natali S, Farinelli L, Screpis D, Trojan D, Montagner G, Favaretto F, and Zorzi C
- Abstract
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of joints. Among various cell therapies, mesenchymal stem cell (MSC) therapy appears to provide encouraging results. Human amniotic suspension allografts (HASA) have anti-inflammatory and chondroregenerative potential and represent a promising treatment strategy. The purpose of the present study was to prospectively assess the safety, clinical effectiveness, and feasibility of intra-articular injections of human amniotic suspension allograft (HASA) in unilateral knee OA in order to assess the improvement of symptoms and delay the necessity for invasive surgical procedures. A total of 25 symptomatic patients, affected by knee OA were treated with 3 mL of HASA. Clinical evaluations before the treatment and after 3, 6, and 12 months were performed through International Knee Documentation Committee (IKDC) score and Visual Analogue Scale (VAS) scores. Adverse events were recorded. No severe complications were noted during the treatment and the follow-up period. A statistically significant improvement from basal evaluation to the 3-, 6-, and 12-month follow-up visits was observed. The present pilot study indicates that a single intra-articular injection of HASA seems safe and able to provide positive clinical outcomes, potentially offering a new minimally invasive therapeutic option for patients with knee OA.
- Published
- 2022
- Full Text
- View/download PDF
24. Lateral extra-articular tenodesis and anterior cruciate ligament reconstruction in young patients: clinical results and return to sport.
- Author
-
Guarino A, Farinelli L, Iacono V, Screpis D, Piovan G, Rizzo M, Mariconda M, and Zorzi C
- Abstract
Lateral extra-articular tenodesis (L.E.T.) have been proposed to reduce the tibia's anterior translation and internal rotation in concomitant to Anterior cruciate ligament (A.C.L.) reconstruction. Recent studies show that the addition of L.E.T. to A.C.L. reconstruction results in a statistically significant reduction in graft failure. The purpose of the present study was to evaluate the clinical outcomes, complications, and rate of return to preinjury sports level in pediatric patients who underwent combined A.C.L. reconstruction with L.E.T. at a minimum 2-year follow-up. The authors retrospectively evaluated 42 pediatric patients at high risk of graft failure who experienced ACLR connected to L.E.T. IKDC and Tegner-Lysholm Knee Scores Scale were used to assess clinical outcomes, and the Tegner Activity Scale to evaluate the return to sport. No graft failure or subsequent surgery related to A.C.L. reconstruction occurred. Furthermore, 88% of patients returned to the sport. Satisfactory clinical results were obtained on a short and medium-term follow-up. These findings help to consider this procedure for active adolescents at a high risk of graft failure to enhance A.C.L. reconstruction., Competing Interests: All authors declare that there is no conflict of interest.
- Published
- 2022
- Full Text
- View/download PDF
25. Tibial Tubercle Screw Fixation on Custom Metaphyseal Cone: Surgical Tip in Severe Metaphyseal Tibia Bone Loss.
- Author
-
Piovan G, Farinelli L, Screpis D, Povegliano L, Gigante AP, and Zorzi C
- Abstract
Tibial tubercle osteotomy (TTO) facilitates exposure in knee arthroplasty revision. However, it comes with complications, especially if it invades the intramedullary canal. Most revisions are characterized by compromised femur and/or tibia bone stock, and the use of metaphyseal cones or sleeves for implant fixation has become increasingly frequent. Several methods of fixation of the tibial tubercle have been proposed, such as screw fixation, cerclage wiring, and suture repair. Despite screws providing the strongest fixation for TTO, their placement around a tibial intramedullary stem or a metaphyseal tibial cone may be difficult. We described the use of a custom-made metaphyseal tibial cone with holes in its anterior surface that allow the surgeon to achieve accurate TTO fixation by screws., (© 2022 The Authors.)
- Published
- 2022
- Full Text
- View/download PDF
26. Autologous Microfragmented Adipose Tissue for the Treatment of Knee Osteoarthritis: Real-World Data at Two Years Follow-Up.
- Author
-
Screpis D, Natali S, Farinelli L, Piovan G, Iacono V, de Girolamo L, Viganò M, and Zorzi C
- Abstract
The purpose of the present study was to assess, prospectively, the safety, clinical effectiveness, and feasibility of a single intra-articular injection of microfragmented adipose tissue in different stages of knee osteoarthritis (OA). The study included patients (aged 18−70 years), affected by OA (Kellgren−Lawrence I-IV). Unselected patients were evaluated before and prospectively after 6, 12, and 24 months from the injection. Visual analog scale (VAS) and knee injury and osteoarthritis outcome score (KOOS) were used for clinical evaluations. A total of 202 patients were eligible. The mean follow-up time in the cohort of patients was 24.5 ± 9.6 months. Total KOOS significantly improved from pre-operative baseline levels to 6-month follow-up (p < 0.001), and again between 6- and 12-month follow-ups (p < 0.001). The VAS showed a prompt reduction at 6 months (p < 0.001 vs. baseline), but then it increased again at 12 months compared to the 6-month assessment (p < 0.001), even though it remained lower than baseline (p < 0.001). At 24 months, patients with KL-IV demonstrated a lower improvement compared to baseline; patients that had undergone previous corticosteroid injections had a greater risk to further injection treatment. The collected clinical results suggest that MFAT may represent a safe and effective treatment for OA symptoms, offering a low-demanding and minimally invasive treatment.
- Published
- 2022
- Full Text
- View/download PDF
27. The use of autologous platelet-rich fibrin matrix combined with meniscal repair in the treatment of parameniscal cyst: clinical results and cyst recurrence after 2-year of follow up.
- Author
-
Screpis D, Piovan G, Natali S, Pasqualotto S, Magnanelli S, Iacono V, Farinelli L, Grassi M, and Zorzi C
- Abstract
Purpose: Parameniscal cysts are associate with horizontal meniscal tears. Arthroscopic meniscal repair and the excision of the cyst by mini-open approach represent a valid treatment. However, the recurrence of cyst is still a current issue. Therefore, biological factors may be considered to promote the biological repair and avoid recurrence. The aim of the present study was to report the clinical results and the rate of recurrence of the cyst after minimum 2-year of follow up in a cohort of patients treated by meniscal repair and autologous platelet-rich fibrin matrix augment., Methods: Patients with lateral parameniscal cyst undergoing arthroscopic meniscal repair and autologous platelet-rich fibrin matrix augment between 2016 and 2019 were retrospectively reviewed in March 2021. Inclusion criteria were absence of prior surgery on the affected knee with minimum 2-year of follow-up. Exclusion criteria were concomitant ligament lesions, rheumatic diseases and knee osteoarthritis. After reviewing the database, each selected patient was contacted and asked to participate in the study; at the follow-up evaluation all patient signed an informed consent. Tegner-Lysholm knee score, IKDC and NRS were collected before surgery and at follow-up., Results: This study included 15 patients (8 male) with mean age of 32.8 years old. No recurrence of the cysts was observed. The Tegner-Lysholm knee score and IKDC subjective scores increased respectively from 41.3 ± 5.4 and 37.6 ± 5.1 at baseline to 92.3 ± 4.6 and 89.4 ± 2.6 at the final follow up. Concerning pain relief, the Numeric Pain Rating Scale (NRS) displayed a significant improvement reaching at the follow up a score of 1,3 ± 1.1 in comparison to 6.8 ± 0.9 at the baseline., Conclusion: Surgical management of symptomatic lateral parameniscal cyst with cyst excision, autologous PRP membrane application and meniscus repair demonstrated excellent subjective clinical outcome with any cyst reoccurrence., Level of Evidence: III, retrospective cohort study., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
28. Operating procedures for electrochemotherapy in bone metastases: Results from a multicenter prospective study on 102 patients.
- Author
-
Campanacci L, Bianchi G, Cevolani L, Errani C, Ciani G, Facchini G, Spinnato P, Tognù A, Massari L, Cornelis FH, Mosconi M, Screpis D, Benazzo F, Rossi B, Bonicoli E, Fazioli F, Nicolosi M, Boffano M, Piana R, De Terlizzi F, Cadossi M, and Donati DM
- Subjects
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents administration & dosage, Bone Nails, Bone Neoplasms complications, Bone Neoplasms surgery, Cancer Pain drug therapy, Cancer Pain etiology, Disease Progression, Electrochemotherapy adverse effects, Female, Fracture Fixation, Intramedullary, Fractures, Spontaneous etiology, Humans, Male, Middle Aged, Prospective Studies, Quality of Life, Response Evaluation Criteria in Solid Tumors, Bone Neoplasms drug therapy, Bone Neoplasms secondary, Electrochemotherapy methods, Fractures, Spontaneous surgery
- Abstract
Introduction: Bone metastases are frequent in patients with cancer. Electrochemotherapy (ECT) is a minimally invasive treatment. Preclinical and clinical studies supported the use of ECT in patients with metastatic bone disease (MBD). The purposes of this multicentre study are to confirm the safety and efficacy of ECT, and to identify appropriate operating procedures in different MBD conditions., Materials and Methods: 102 patients were treated in 11 Centres and recorded in the REINBONE registry (a shared database protected by security passwords): clinical and radiological information, ECT session, adverse events, response, quality of life indicators and duration of follow-up were registered., Results: 105 ECT sessions were performed (one ECT session in 99 patients, two ECT sessions in 3 patients). 24 patients (23.5%) received a programmed intramedullary nail after ECT, during the same surgical procedure. Mean follow-up was 5.9 ± 5.1 months (range 1.5-52). The response to treatment by RECIST criteria was 40.4% objective responses, 50.6% stable disease and 9% progressive disease. According to PERCIST criteria the response was: 31.4% OR; 51.7% SD, 16.9% PD with no significant differences between the 2 criteria. Diagnosis of breast cancer and ECOG values 0-1 were significantly associated to objective response. A significant decrease in pain intensity and significant better quality of life was observed after ECT session at follow-up., Conclusion: The results are encouraging on pain and tumour local control. ECT proved to be an effective and safe treatment for MBD and it should be considered as an alternative treatment as well as in combination with radiation therapy., Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest with the trademarks included in the manuscript. All authors disclose no personal, financial or non-financial competing interests. Francesca de Terlizzi and Matteo Cadossi are IGEA employers. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
29. Autologous Platelet-Rich Fibrin Matrix-Augmented Repair for Parameniscal Cysts: Surgical Technique.
- Author
-
Screpis D, Natali S, Piovan G, Iacono V, Magnanelli S, Farinelli L, and Zorzi C
- Abstract
Parameniscal cysts are defined as an internal disorder of the knee joint. It is known that parameniscal cysts are associated with horizontal meniscal tears that could lead to the collection of synovial fluid within the cyst. Despite the treatment of meniscal tears, cyst recurrence is still an issue that needs to be addressed. In this regard, there has been an increasing interest in the use of biologic agents to enhance the vascularity and healing of the meniscus. Preliminary results for biologic therapeutic agents, such as growth factors, bone marrow, and aspirate concentrate, have been encouraging. However, these options are more demanding in regards to time, financial burden, resources, and so on. Autologous platelet-rich plasma is readily available, easy to use, affordable, and minimally invasive. This Technical Note will describe a step-by-step and reproducible technique for the harvesting, preparation, and use of an autologous platelet-rich fibrin matrix used to augment the healing of meniscal repairs., (© 2021 by the Arthroscopy Association of North America. Published by Elsevier.)
- Published
- 2021
- Full Text
- View/download PDF
30. The use of intra-articular injection of autologous micro-fragmented adipose tissue as pain treatment for ankle osteoarthritis: a prospective not randomized clinical study.
- Author
-
Natali S, Screpis D, Farinelli L, Iacono V, Vacca V, Gigante A, and Zorzi C
- Subjects
- Adipose Tissue, Humans, Injections, Intra-Articular, Pain, Prospective Studies, Transplantation, Autologous, Treatment Outcome, Ankle, Osteoarthritis, Knee
- Abstract
Purpose: The objective of this study was to evaluate the safety and the efficacy of intra-articular injections of autologous micro-fragmented adipose tissue in patients affected by early or moderate ankle osteoarthritis (AOA)., Methods: A total of 31 symptomatic patients, aged 28-71 years, affected by AOA, were treated with 5 ml of autologous micro-fragmented adipose tissue. Clinical evaluations before the treatment and after six, 12, and 24 months were performed through American Orthopaedic Foot and Ankle Society (AOFAS) scale, the Foot and Ankle Disability Index (FADI), and Visual Analogue Scale (VAS) scores. Adverse events were recorded., Results: No severe complications were noted during the treatment and the follow-up period. A statistically significant improvement from basal evaluation to the six, 12-, and 24-month follow-up visit was observed, whereas a statistically significant worsening from the 12-month to the 24-month follow-up visit was showed., Conclusion: The autologous micro-fragmented adipose tissue for the treatment of pain in ankle osteoarthritis seems safe and able to provide positive clinical outcomes, potentially offering a new minimally invasive therapeutic option for patients who are not eligible for more invasive approaches. Further high-quality studies are needed to confirm these findings., (© 2021. SICOT aisbl.)
- Published
- 2021
- Full Text
- View/download PDF
31. Open-Wedge High Tibial Osteotomy Associated With Lipogems® Intra-Articular Injection For The Treatment Of Varus Knee Osteoarthritis - Retrospective Study.
- Author
-
Magnanelli S, Screpis D, Di Benedetto P, Natali S, Causero A, and Zorzi C
- Subjects
- Humans, Injections, Intra-Articular, Osteotomy, Retrospective Studies, Tibia surgery, Treatment Outcome, Osteoarthritis, Knee complications, Osteoarthritis, Knee drug therapy, Osteoarthritis, Knee surgery
- Abstract
Background and Aim: Open-wedge high tibial osteotomy (HTO) is a good choice in the treatment of varus knee medial osteoarthritis, with the restore of the correct mechanical axis of the lower limb. Autologous adipose derived stem cells (aASCs) are used in cartilage regeneration and in the treatment of early osteoarthritis. Aim of this study is to retrospectively analyze clinical (and radiological) results in two populations of patients with initial varus medial knee osteoarthritis, treated with HTO, with or without associated intra-articular injection of aASCs., Methods: In this study we analyze 85 patients treated with HTO for varus knee osteoarthritis with or without Lipogems® intra-articular injection. It was used of a single model of HTO plate. No associated procedure was performed., Results: Significant improvement in the daily life activity assessment (KOOS score) was observed in the group treated also with aASCs compared with group treated with isolated HTO., Conclusions: We suggest, in these patients, the surgical indication of an open-wedge high tibial osteotomy (HTO) and simultaneous injection with aASCs associated procedure to improve cartilage regeneration, with clinical improvement.
- Published
- 2020
- Full Text
- View/download PDF
32. Elective Orthopaedic Surgery During COVID-19: A Safe Way to Get Back on Track.
- Author
-
Zorzi C, Piovan G, Screpis D, Natali S, Marocco S, and Iacono V
- Abstract
The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has greatly changed our way of living and working. We have developed a method to treat urgent patients in a safe way, and we applied the same protocol to resume elective surgical procedures., Methods: We reorganized the system and the management of our orthopaedic department to perform elective surgical procedures in a safe way. During the COVID-19 lockdown, 614 patients underwent elective orthopaedic procedures., Results: No major postoperative complications were recorded. None of the orthopaedic surgeons, health-care personnel, or hospitalized patients was infected in this period of activity., Conclusions: During COVID-19, it is possible to perform elective surgical procedures in a safe way., Competing Interests: Disclosure: The authors indicated that no external funding was received for any aspect of this work. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSOA/A223)., (Copyright © 2020 The Authors. Published by The Journal of Bone and Joint Surgery, Incorporated. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
33. All-inside repair of meniscal bucket handle tears: a retrospective study at mean 4-years follow-up evaluation.
- Author
-
Nobile F, Condello V, Madonna V, Screpis DU, Di Donato SL, Kon E, Marcacci M, Di Matteo B, and Zorzi C
- Subjects
- Arthroscopy, Follow-Up Studies, Humans, Menisci, Tibial surgery, Retrospective Studies, Tibial Meniscus Injuries surgery
- Abstract
Bucket-handle tears represent approximately 10% of all meniscal tears. Despite the common treatment is subtotal meniscectomy, repair is technically feasible although complex, and represents a key strategy to avoid severe meniscal tissue loss that could accelerate joint degeneration over time. The aim of this retrospective study was to determine the outcomes of arthroscopically-assisted bucket-handle tear repair, and to identify factors correlating with clinical results. Fifty-four patients affected by meniscal bucket handle tear were included in the present retrospective analysis and evaluated up to mean 4-years follow-up. All patients were treated by arthroscopic-assisted all-inside repair. The primary outcome was considered the need for a re-operation due to failure of meniscal repair. Patients were also evaluated by the following items: KOOS, Lysholm, Tegner, IKDC-subjective and Quadruple-VAS score. Subgroup analysis was performed to identify whether concurrent ACL reconstruction, side of the lesion, age at surgery and time from injury to repair could influence clinical outcome. Ten out 54 patients (18.5%) were considered failed and needed reoperation, mainly within one year from surgery. Overall, there was a significant increase in all clinical scores considered and patients were able to get back to previous sport activity level. Patients with concurrent ACL reconstruction presented a lower risk of failure (p=0.025). Patients with lateral meniscus repair showed better clinical outcome compared to medial meniscus. Timing from injury and age at surgery did not correlated with clinical outcome. Our series showed fair results in bucket handle repair up to middle term evaluation. Concomitant ACL reconstruction was associated with lower failure rate whereas lateral meniscus involvement was associated with higher functional scores at final follow-up evaluation., (Copyright 2020 Biolife Sas. www.biolifesas.org.)
- Published
- 2020
34. Use of a Biomimetic Scaffold for the Treatment of Osteochondral Lesions in Early Osteoarthritis.
- Author
-
Condello V, Filardo G, Madonna V, Andriolo L, Screpis D, Bonomo M, Zappia M, Dei Giudici L, and Zorzi C
- Subjects
- Adult, Animals, Bone Development drug effects, Collagen Type I chemistry, Durapatite administration & dosage, Female, Horses, Humans, Knee Joint diagnostic imaging, Knee Joint drug effects, Knee Joint physiopathology, Knee Joint surgery, Lysholm Knee Score, Magnetic Resonance Imaging, Male, Middle Aged, Osteoarthritis diagnostic imaging, Osteoarthritis physiopathology, Osteoarthritis surgery, Pain diagnostic imaging, Pain physiopathology, Pain surgery, Regeneration, Reoperation, Tissue Scaffolds chemistry, Biomimetics, Collagen Type I administration & dosage, Osteoarthritis drug therapy, Pain drug therapy
- Abstract
The aim of this study is to investigate clinical and radiographic outcomes of a biomimetic scaffold for the treatment of osteochondral knee lesions in patients with early OA. Study population was represented by 26 patients with a mean age of 44 years affected by early OA. Inclusion criteria were two episodes of knee pain for more than 10 days in the last year, Kellgren-Lawrence OA grade 0 or I or II, and arthroscopic findings of cartilage defects. Nineteen patients had a previous surgery, 11 of which were revision surgeries of osteochondral unit. All patients were treated with a biomimetic scaffold with a tri-layered structure of type I equine collagen and magnesium-enriched hydroxyapatite. Clinical outcomes were evaluated using the IKDC, Lysholm, VAS, KOOS, and Tegner scores at baseline and at an average follow-up of 35 months. Magnetic resonance imaging (MRI) was performed at follow-up time in 19 patients. Clinical outcomes showed significant improvement in VAS, Lysholm, IKDC subjective score, and KOOS subscales in 69% of the patients. Complication rate of this cases series was 11%, with no surgical failure, although 31% of patients did not reach a significant improvement and were thus considered as clinical failure. MRI analysis showed integration of the scaffold only in 47% of the patients, with partial regeneration of the subchondral bone. No correlation between clinics and radiological images was found. The use of a biomimetic osteochondral scaffold in the setting of an early OA, alone or associated with other procedures, appeared to be a valid and safe option, able to provide good and stable clinical outcomes with high patient's satisfaction and low complication rate.
- Published
- 2018
- Full Text
- View/download PDF
35. Use of the KineSpring system in the treatment of medial knee osteoarthritis: preliminary results.
- Author
-
Madonna V, Condello V, Piovan G, Screpis D, and Zorzi C
- Abstract
Purpose: the purpose of this study was to analyze our preliminary results obtained with the KineSpring system in patients suffering from medial compartment knee osteoarthritis (OA)., Methods: between September 2012 and May 2014, 53 patients underwent treatment with the KineSpring system. Patient self-assessment was performed pre-operatively and at 3, 6 and 12 months postoperatively, and included the KOOS, Tegner activity score, Lysholm functional knee score, VAS knee pain score, and IKDC score. Device- and procedure-related adverse events were recorded., Results: mean KOOS subscales, except for the Sport/Recreation subscale at six months, improved over time. Mean WOMAC Pain and Function domains, Lysholm score, IKDC score and VAS knee pain score improved over the follow-up period and were significantly improved at 3, 6 and 12 months postoperatively compared to baseline. Mean Tegner score improved slightly over time. In 5 of the 53 (9.4%) patients re-operation was necessary. In 3 patients the device was removed due to infection (one case) or persistent knee pain (two cases). Surgical arthrolysis was performed in two patients., Conclusions: in our preliminary experience, the KineSpring system gave good short-term clinical results., Level of Evidence: Level IV, therapeutic case series.
- Published
- 2016
- Full Text
- View/download PDF
36. A new hydrogel for the conservative treatment of meniscal lesions: a randomized controlled study.
- Author
-
Zorzi C, Rigotti S, Screpis D, Giordan N, and Piovan G
- Abstract
Purpose: this study aimed to investigate the efficacy of intra-articular (IA) administration of a hydrogel formulation obtained from a hyaluronic acid (HA) derivative (HYADD4(®)) in the management of meniscal tears and in meniscal tear repair., Methods: fifty subjects with degenerative meniscal tears were enrolled into this single-site, observer-blind, parallel-group study. Clinical evaluations were performed at baseline and after 14, 30 and 60 days. Clinical outcomes included: pain reduction (Visual Analog Scale), improvement of knee functionality (WOMAC questionnaire), reduction in length and depth of the meniscal lesion (MRI-confirmed) and SF-36 questionnaire scores. Local tolerability and safety were also investigated., Results: a significant reduction in VAS pain (p< 0.001) in favor of HYADD4(®) was recorded at day 14 and maintained at all the follow-up assessments. Data on knee functionality were in line with the VAS pain assessment results. A significant reduction in length and depth of the meniscal lesion, assessed using MRI, was found in the HYADD4(®) group compared to the control group (p<0.001)., Conclusions: the results of this study may indicate a new treatment option in the conservative management of patients complaining of pain due to meniscal tears. The MRI data suggest that the hydrogel formulation of HA used in this study may also play a role in the healing process of the lesion., Level of Evidence: Level I, prospective randomized clinical trial.
- Published
- 2016
- Full Text
- View/download PDF
37. The first case of Nocardia beijingensis isolated infection to lumbar spine.
- Author
-
Rigotti S, Marocco S, Angheben A, Screpis D, Piovan G, and Zorzi C
- Published
- 2015
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.