Search

Your search keyword '"Sebastian Gimpfl"' showing total 4 results
Start Over Author "Sebastian Gimpfl"
4 results on '"Sebastian Gimpfl"'

1. Evaluating Various Methods Used by Direct-to-Consumer Products Promising Personalized Nutrition

Author

Sebastian Gimpfl, Kseniia Steinle, and Kurt Gedrich

Subjects
personalized nutrition, nutrition requirements, nutrition guidelines, diet, food, and nutrition, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

The increasing availability of direct-to-consumer personalized nutrition products has raised questions about their scope of personalization and added value compared to general dietary guidelines. This study evaluated eleven personalized nutrition products across six distinct methodologies, including DNA analysis, blood marker analysis, microbiome testing, blood glucose monitoring, questionnaire-based personalization, and consultation with a dietitian, comparatively evaluating their consistency and added value compared to general dietary guidelines. A 24-year-old obese male with no pre-existing illnesses was chosen as the case participant to represent a typical individual seeking personalized nutrition advice for weight loss. Significant variability and inconsistency were observed across and within the different methodologies, particularly in recommendations for energy intake and macronutrient distribution. Most advice was generic and aligned closely with existing dietary guidelines, with a notable lack of behavioral change strategies. This study underscores the challenges in personalized nutrition, highlighting the problem that current practices often fall short of delivering truly tailored recommendations. There is a critical need for clearer definitions, evidence-based guidelines, and more comprehensive approaches to fully realize the potential of personalized nutrition in improving individual health.

Published
2024
Full Text
View/download PDF

2. Does the habitual dietary intake of adults in Bavaria, Germany, match dietary intake recommendations? Results of the 3rd Bavarian Food Consumption Survey

Author

Florian Rohm, Nina Wawro, Sebastian Gimpfl, Nadine Ohlhaut, Melanie Senger, Christine Röger, Martin Kussmann, Kurt Gedrich, and Jakob Linseisen

Subjects
dietary intake, Bavaria, BVS III, NCI method, 24-h-recalls, nutrients, Nutrition. Foods and food supply, TX341-641
Abstract

ObjectiveMonitoring dietary habits is crucial for identifying shortcomings and delineating countermeasures. About 20 years after the last population-based surveys in Bavaria and Germany, dietary habits were assessed to describe the intake distributions and compare these with recommendations at food and nutrient level.MethodsThe 3rd Bavarian Food Consumption Survey (BVS III) was designed as a diet survey representative of adults in Bavaria; from 2021 to 2023, repeated 24-h diet recalls were collected by telephone using the software GloboDiet©. Food (sub-)group and nutrient intake data were modeled with the so-called NCI method, weighted for the deviation from the underlying population. Intake distributions in men and women were described as percentiles. These data were used to estimate the proportion of persons meeting dietary intake recommendations. In addition, food consumption data were compared with the results reported 20 years ago collected by the same methodology (2nd Bavarian Food Consumption Survey, BVS II).ResultsUsing 24-h diet recalls of 550 male and 698 female participants, we estimated intake distributions for food (sub-)groups and nutrients. A major proportion of the adult population does not meet the food-based dietary guidelines; this refers to a series of food groups, including fruit and vegetables, legumes, nuts, cereal products, and especially whole grain products, as well as fresh and processed meat. Regarding selected essential nutrients, a considerable proportion of the population was at higher risk of insufficiency from iron (women), zinc (men), and folate (both men and women), as already described in previous studies.ConclusionA major proportion of the adult Bavarian population does not meet the current food-based dietary guidelines. Compared to BVS II data, favorable changes refer to lower consumption of total meat (especially processed meat) and soft drinks, and an increased intake of vegetables. The conclusions based on the intake of selected essential nutrients hardly changed over time. From a public health perspective, the still low intake of vegetables, fruit, nuts, cereal products, and particularly of whole grain products, and associated higher risks of insufficient supply of several vitamins and minerals call for action for improvement.

Published
2025
Full Text
View/download PDF

3. Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

Author

James R. A. Skipworth, Sebastian Krug, Florence Bühler, Sebastian Gimpfl, Joachim Mössner, Anke Tönjes, Atsushi Masamune, Adrian Saftoiu, Roland H. Pfützer, Marcella Rietschel, Heiko Witt, Felix Stickel, Jens Werner, Peter Kovacs, Nicole Soranzo, Constantin Zimmer, Martin Ziegler, Helmut Laumen, Holger Kirsten, Marco J. Bruno, Joost P.H. Drenth, Markus M. Lerch, Markus M. Nöthen, Claus Hellerbrand, Annette Peters, Philippe Lévy, Jian-Min Chen, Monika Ridinger, Giulia Martina Cavestro, Emmanuelle Masson, Milena Di Leo, Peter Simon, Peter Bugert, Péter Hegyi, Karl Mann, Miklós Sahin-Tóth, Pier Alberto Testoni, Núria Malats, Rene H. M. te Morsche, Konstantin Strauch, Stephen P. Pereira, Josef Frank, Norbert Wodarz, Halina Cichoż-Lach, Jonas Rosendahl, Alexander Schneider, Marcus Hollenbach, Olfert Landt, Markus Löffler, Sergio Pedrazzoli, Volker Keim, Matthias Löhr, Marie Motyka, Sebastian Mueller, Ralph Burkhardt, Antoni Farré, Heidi Griesmann, Falk Kiefer, Giovanni Malerba, Claudia Ruffert, Markus Scholz, Francisco X. Real, Maren Ludwig, Eszter Hegyi, Harald Grallert, Hana Algül, Vinciane Rebours, Eva Rösmann, Frank Ulrich Weiss, Sonja Mohr, Robert Grützmann, Sevastitia Iordache, Michael Soyka, Milan Macek, Peter Lichtner, Patrick Michl, Claude Férec, Giovanni Gambaro, Michael Stumvoll, Katharina Seltsam, Thomas Müller, Grazyna Jurkowska, Ewa Małecka-Panas, Sebastian Beer, Julia Mayerle, Hans-Ulrich Schulz, Lena Werner, Publica, Rosendahl, Jona, Kirsten, Holger, Hegyi, Eszter, Kovacs, Peter, Weiss, Frank Ulrich, Laumen, Helmut, Lichtner, Peter, Ruffert, Claudia, Chen, Jian min, Masson, Emmanuelle, Beer, Sebastian, Zimmer, Constantin, Seltsam, Katharina, Algül, Hana, Bühler, Florence, Bruno, Marco J, Bugert, Peter, Burkhardt, Ralph, Cavestro, GIULIA MARTINA, Cichoz lach, Halina, Farré, Antoni, Frank, Josef, Gambaro, Giovanni, Gimpfl, Sebastian, Grallert, Harald, Griesmann, Heidi, Grützmann, Robert, Hellerbrand, Clau, Hegyi, Péter, Hollenbach, Marcu, Iordache, Sevastitia, Jurkowska, Grazyna, Keim, Volker, Kiefer, Falk, Krug, Sebastian, Landt, Olfert, Leo, Milena Di, Lerch, Markus M, Lévy, Philippe, Löffler, Marku, Löhr, Matthia, Ludwig, Maren, Macek, Milan, Malats, Nuria, Malecka panas, Ewa, Malerba, Giovanni, Mann, Karl, Mayerle, Julia, Mohr, Sonja, Te Morsche, Rene H. M, Motyka, Marie, Mueller, Sebastian, Müller, Thoma, Nöthen, Markus M, Pedrazzoli, Sergio, Pereira, Stephen P, Peters, Annette, Pfützer, Roland, Real, Francisco X, Rebours, Vinciane, Ridinger, Monika, Rietschel, Marcella, Rösmann, Eva, Saftoiu, Adrian, Schneider, Alexander, Schulz, Hans ulrich, Soranzo, Nicole, Soyka, Michael, Simon, Peter, Skipworth, Jame, Stickel, Felix, Strauch, Konstantin, Stumvoll, Michael, Testoni, PIER ALBERTO, Tönjes, Anke, Werner, Lena, Werner, Jen, Wodarz, Norbert, Ziegler, Martin, Masamune, Atsushi, Mössner, Joachim, Férec, Claude, Michl, Patrick, Joost, P. H. Drenth, Witt, Heiko, Scholz, Marku, Sahin tóth, Miklós, and Gastroenterology & Hepatology

Subjects
0301 basic medicine, Linkage disequilibrium, medicine.medical_specialty, Settore MED/12 - GASTROENTEROLOGIA, Population, Genome Wide Association Study, Chronic Pancreatitis, Genetic Rearrangement, Locus (genetics), Single-nucleotide polymorphism, Genome-wide association study, Biology, Gastroenterology, chronic pancreatitis, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Genetic predisposition, medicine, Allele, education, Genetics, education.field_of_study, medicine.disease, ddc, genetic rearrangement, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, Genome wide association study, Pancreatitis, chronic pancreatiti, Chronic pancreatitis, Genetic rearrangement
Abstract

ObjectiveAlcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.Design1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.ResultsWe replicated previously reported risk loci CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 in alcoholic CP patients. We identified CTRB1-CTRB2 (chymotrypsin B1 and B2) as a new risk locus with lead single-nucleotide polymorphism (SNP) rs8055167 (OR 1.35, 95% CI 1.23 to 1.6). We found that a 16.6 kb inversion in the CTRB1-CTRB2 locus was in linkage disequilibrium with the CP-associated SNPs and was best tagged by rs8048956. The association was replicated in three independent European non-alcoholic CP cohorts of 1650 patients and 6695 controls (OR 1.62, 95% CI 1.42 to 1.86). The inversion changes the expression ratio of the CTRB1 and CTRB2 isoforms and thereby affects protective trypsinogen degradation and ultimately pancreatitis risk.ConclusionAn inversion in the CTRB1-CTRB2 locus modifies risk for alcoholic and non-alcoholic CP indicating that common pathomechanisms are involved in these inflammatory disorders.

Published
2018

4. Genome-wide association study identifies inversion in the

Author

Jonas, Rosendahl, Holger, Kirsten, Eszter, Hegyi, Peter, Kovacs, Frank Ulrich, Weiss, Helmut, Laumen, Peter, Lichtner, Claudia, Ruffert, Jian-Min, Chen, Emmanuelle, Masson, Sebastian, Beer, Constantin, Zimmer, Katharina, Seltsam, Hana, Algül, Florence, Bühler, Marco J, Bruno, Peter, Bugert, Ralph, Burkhardt, Giulia Martina, Cavestro, Halina, Cichoz-Lach, Antoni, Farré, Josef, Frank, Giovanni, Gambaro, Sebastian, Gimpfl, Harald, Grallert, Heidi, Griesmann, Robert, Grützmann, Claus, Hellerbrand, Péter, Hegyi, Marcus, Hollenbach, Sevastitia, Iordache, Grazyna, Jurkowska, Volker, Keim, Falk, Kiefer, Sebastian, Krug, Olfert, Landt, Milena Di, Leo, Markus M, Lerch, Philippe, Lévy, Markus, Löffler, Matthias, Löhr, Maren, Ludwig, Milan, Macek, Nuria, Malats, Ewa, Malecka-Panas, Giovanni, Malerba, Karl, Mann, Julia, Mayerle, Sonja, Mohr, Rene H M, Te Morsche, Marie, Motyka, Sebastian, Mueller, Thomas, Müller, Markus M, Nöthen, Sergio, Pedrazzoli, Stephen P, Pereira, Annette, Peters, Roland, Pfützer, Francisco X, Real, Vinciane, Rebours, Monika, Ridinger, Marcella, Rietschel, Eva, Rösmann, Adrian, Saftoiu, Alexander, Schneider, Hans-Ulrich, Schulz, Nicole, Soranzo, Michael, Soyka, Peter, Simon, James, Skipworth, Felix, Stickel, Konstantin, Strauch, Michael, Stumvoll, Pier Alberto, Testoni, Anke, Tönjes, Lena, Werner, Jens, Werner, Norbert, Wodarz, Martin, Ziegler, Atsushi, Masamune, Joachim, Mössner, Claude, Férec, Patrick, Michl, Joost, P H Drenth, Heiko, Witt, Markus, Scholz, and Miklós, Sahin-Tóth

Subjects
Adult, Europe, Male, Pancreatitis, Alcoholic, Chymotrypsin, Humans, Female, Genetic Predisposition to Disease, Middle Aged, Polymorphism, Single Nucleotide, Aged
Abstract

Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis (CP) is poorly characterised. To identify risk genes for alcoholic CP and to evaluate their relevance in non-alcoholic CP, we performed a genome-wide association study and functional characterisation of a new pancreatitis locus.1959 European alcoholic CP patients and population-based controls from the KORA, LIFE and INCIPE studies (n=4708) as well as chronic alcoholics from the GESGA consortium (n=1332) were screened with Illumina technology. For replication, three European cohorts comprising 1650 patients with non-alcoholic CP and 6695 controls originating from the same countries were used.We replicated previously reported risk lociAn inversion in the

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results