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366 results on '"Secil, Mustafa"'

1. The role of the radiologist in the evaluation of male infertility: recommendations of the European Society of Urogenital Radiology-Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for scrotal imaging

Author

Lotti, Francesco, Studniarek, Michal, Balasa, Cristina, Belfield, Jane, De Visschere, Pieter, Freeman, Simon, Kozak, Oliwia, Markiet, Karolina, Ramanathan, Subramaniyan, Richenberg, Jonathan, Secil, Mustafa, Skrobisz, Katarzyna, Tsili, Athina C., Bertolotto, Michele, and Rocher, Laurence

Published
2024
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4. Unusual Presentations of LMNA-Associated Lipodystrophy with Complex Phenotypes and Generalized Fat Loss: When the Genetic Diagnosis Uncovers Novel Features

Author

de Andrade, Natalia Xavier S., Adiyaman, Suleyman Cem, De Yuksel, Bernamir, Ferrari, Carla T., Eldin, Abdelwahab Jalal, Saydam, Basak Ozgen, Altay, Canan, Sharma, Pratima, Bhave, Nicole, Little, Ann, McKeever, Paul, Onay, Huseyin, Ozkal, Sermin, Secil, Mustafa, Yenerel, Mustafa Nuri, Akinci, Baris, and Oral, Elif A.

Published
2020
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8. Clinical presentations, metabolic abnormalities and end-organ complications in patients with familial partial lipodystrophy

Author

Akinci, Baris, Onay, Huseyin, Demir, Tevfik, Savas-Erdeve, Şenay, Gen, Ramazan, Simsir, Ilgin Yildirim, Keskin, Fatma Ela, Erturk, Mehmet Sercan, Uzum, Ayse Kubat, Yaylali, Guzin Fidan, Ozdemir, Nilufer Kutbay, Atik, Tahir, Ozen, Samim, Yurekli, Banu Sarer, Apaydin, Tugce, Altay, Canan, Akinci, Gulcin, Demir, Leyla, Comlekci, Abdurrahman, Secil, Mustafa, and Oral, Elif Arioglu

Published
2017
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11. N-NITRO-L-ARGININE METHYL ESTER HYDROCHLORIDE INDUCED ENDOTHELIAL DYSFUNCTION AND ATHEROSCLEROSIS MODEL IN RATS.

Author

Simsek, Muhammet Kursat, Baris, Mustafa Mahmut, Yilmaz, Osman, Altun, Zekiye Sultan, Aktas, Safiye, Cakir, Yasemin, Buyukcoban, Sibel, and Secil, Mustafa

Subjects
SALT, BIOLOGICAL models, NITRIC-oxide synthases, ENDOTHELIUM, CAROTID intima-media thickness, ANIMAL experimentation, IMMUNOHISTOCHEMISTRY, ARGININE, INTRAPERITONEAL injections, ATHEROSCLEROSIS, RATS, OXIDOREDUCTASES
Abstract

Purpose: Atherosclerosis (AS) related diseases are the most common causes of mortality worldwide. N-Nitro-LArginine Methyl Ester Hydrochloride (L-NAME)-induced endothelial dysfunction (ED) and AS models require invasive methods for diagnosis. We aimed to establish noninvasive ultrasonography (USG) model for evaluating ED and AS in rats. Material and Methods: 23 Wistar Albino rats were divided into four groups. Right CCA (rCCA), left CCA (lCCA), abdominal aorta (AA), and right iliac artery (rIA) IMT values of all rats were measured at the beginning of the experiment and before sacrification by USG. Right kidney RI values were calculated at similar times also. Histopathological and immunohistochemical analyzes were performed. In the sham group, rats received intraperitoneally (IP) sodium chloride. In the L-NAME groups, IP L-NAME was administered. Results: In the early effect group, significant increase was found in IMT measurements compared to the sham group. In the late effect group, significant increase was found in IMT measurements compared to the sham group. In addition, rRI increased significantly in the group at the end of the experiment. Conclusion: In small animal experiments which ED and AS were studied, a whole-body diagnostic noninvasive model was created for the first time with ultrasonography. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Many Faces of Adrenal Lesions in a Large Patient Cohort: What Has Changed Over the Last Two Decades?

Author

Saydam, Basak Ozgen, Baris, Mustafa, Adiyaman, Suleyman Cem, Demir, Tevfik, Kocdor, Mehmet Ali, Demir, Omer, Secil, Mustafa, and Yener, Serkan

Subjects
ADRENAL tumors, CUSHING'S syndrome, HYPERALDOSTERONISM, ADRENALECTOMY
Abstract

Objective To review the presentation characteristics, clinical and hormonal evaluations, and histopathological results of patients with adrenal lesions over a 21-year period and evaluate the changes across the two decades. Methods This single-center, retrospective study included 1003 patients with adrenal lesions who presented to our department between 2000 and 2021. Clinical, metabolic, hormonal, radiological, and pathological data of the patients were collected. Results Forty-seven percent of the lesions were non-functioning adrenal adenomas. Possible autonomous and autonomous cortisol secretion were detected in 22.2% of the patients. The percentages of the patients diagnosed with pheochromocytoma, primary hyperaldosteronism, adrenal Cushing syndrome, adrenocortical carcinoma, and adrenal metastasis were 7.4%, 4.8%, 4.7%, 0.9%, and 5.6%, respectively. Adrenalectomy was performed in 31.3% of the patients. Functional adrenal lesions were the leading cause of surgery (46.5%), followed by large size and/or suspicious imaging features (38.6%). Among the patients referred to surgery due to large size (≥6 cm), the diagnosis in 19% was metastasis, and in 12.1%, it was primary adrenocortical carcinoma. In patients with adrenal lesions with a size of 4–6 cm and suspicious imaging properties, the rates of metastasis and primary adrenocortical carcinoma were 44.4% and 4.8%, respectively. From the first to the second decade, major differences in presentation characteristics were increased detection of bilateral lesions and increased prevalence of possible autonomous and autonomous cortisol secretion. Conclusions Adrenal lesions are common in the adult population, and while it is important to avoid overtreatment, hormone secretion, and malignancy should not be overlooked. [ABSTRACT FROM AUTHOR]

Published
2023
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