463 results on '"Sedivy, John M."'
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2. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
3. Guidelines for minimal information on cellular senescence experimentation in vivo
4. Loss of epigenetic information as a cause of mammalian aging
5. Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain
6. The role of retrotransposable elements in ageing and age-associated diseases
7. Loss of epigenetic information as a cause of mammalian aging
8. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
9. Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
10. LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
11. Regulation of the somatotropic axis by MYC-mediated miRNA repression
12. Contribution of Retrotransposable Elements to Aging
13. Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways
14. L1 drives IFN in senescent cells and promotes age-associated inflammation
15. L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia
16. Stat3-Mediated Myc Expression is Required for Src Transformation and PDGF-Induced Mitogenesis
17. Identification of CDK4 as a Target of c-MYC
18. Dissociation Among in vitro Telomerase Activity, Telomere Maintenance, and Cellular Immortalization
19. Can Ends Justify the Means?: Telomeres and the Mechanisms of Replicative Senescence and Immortalization in Mammalian Cells
20. Bypass of Senescence After Distruption of p21$^{CIP1/WAF1}$ Gene in Normal Diploid Human Fibroblasts
21. Mitochondria: Masters of Epigenetics
22. LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq
23. Reduced Expression of MYC Increases Longevity and Enhances Healthspan
24. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
25. Sleeping dogs of the genome: Retrotransposable elements may be agents of somatic diversity, disease, and aging
26. Analysis of somatic mutations in senescent cells using single-cell whole-genome sequencing
27. Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
28. Abstract 5297: ONC201 suppresses cancer cell growth in a reconstructed tumor microenvironment that includes chemotherapy-induced senescent fibroblasts
29. How to Learn New and Interesting Things from Model Systems Based on "Exotic" Biological Species
30. Sirt6 regulates lifespan in Drosophila melanogaster
31. Reduced c-Myc Signaling Triggers Telomere-Independent Senescence by Regulating Bmi-1 and $P16^{INK4a}$
32. The effects of aging on the expression of Wnt pathway genes in mouse tissues
33. A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging
34. LINE-1 derepression in senescent cells triggers interferon and inflammaging
35. Interventions to Slow Aging in Humans: Are We Ready?
36. AMP-Insensitive Fructose Bisphosphatase in Escherichia coli and Its Consequences
37. Raf-1 Protein Kinase Activates the NF-κB Transcription Factor by Dissociating the Cytoplasmic NF-κB-IκB Complex
38. Positive Genetic Selection for Gene Disruption in Mammalian Cells by Homologous Recombination
39. The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK
40. Signaling crossroads: The function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction
41. Cellular senescence and organismal aging
42. Aging by epigenetics—A consequence of chromatin damage?
43. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse
44. HUMAN GENOMICS: Sleeping dogs of the genome
45. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death
46. Single Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity Across Different Forms of Cellular Senescence
47. Telomeres Limit Cancer Growth by Inducing Senescence: Long-Sought In Vivo Evidence Obtained
48. Analysis of cell cycle phases and progression in cultured mammalian cells
49. Accumulation of senescent cells in mitotic tissue of aging primates
50. Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression
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