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1,184 results on '"Seedat, S"'

7. Improving access to suicide prevention services through the National Suicide Prevention Framework implementation: The community level evidence-based recommendations

Author

Nyasulu, J C Y, primary, Siddiqi, D A, additional, Seedat, S, additional, Bantjies, J, additional, Udedi, M, additional, Gondwe, S, additional, Kambale, S, additional, Mkandawire, M, additional, Silungwe, N, additional, Hendricks, L A, additional, Maposa, I, additional, Vumu, J, additional, and Skinner, D, additional

Published
2024
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9. Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits

Author

Sumner, JA, Duncan, LE, Wolf, EJ, Amstadter, AB, Baker, DG, Beckham, JC, Gelaye, B, Hemmings, S, Kimbrel, NA, Logue, MW, Michopoulos, V, Mitchell, KS, Nievergelt, C, Rothbaum, A, Seedat, S, Shinozaki, G, and Vermetten, E

Subjects
Cardiovascular Diseases, Genome-Wide Association Study, Humans, Metabolic Syndrome, Multifactorial Inheritance, Stress Disorders, Post-Traumatic, Neurosciences, Public Health and Health Services, Psychology, Psychiatry
Published
2017

10. Associations between neurocognitive functioning and social and occupational resilience among South African women exposed to childhood trauma

Author

Denckla, CA, Consedine, NS, Spies, G, Cherner, M, Henderson, DC, Koenen, KC, and Seedat, S

Subjects
Clinical and Health Psychology, Psychology, Behavioral and Social Science, Basic Behavioral and Social Science, Pediatric, Physical Injury - Accidents and Adverse Effects, Post-Traumatic Stress Disorder (PTSD), Clinical Research, Neurosciences, Mental Health, Trauma, resilience, Sub-Saharan Africa, childhood abuse, Clinical Sciences, Clinical sciences, Applied and developmental psychology, Clinical and health psychology
Abstract

Background: Prior research on adaptation after early trauma among black South African women typically assessed resilience in ways that lacked contextual specificity. In addition, the neurocognitive correlates of social and occupational resilience have not been investigated. Objective: The primary aim of this exploratory study was to identify domains of neurocognitive functioning associated with social and occupational resilience, defined as functioning at a level beyond what would be expected given exposure to childhood trauma. Methods: A sample of black South African women, N = 314, completed a neuropsychological battery, a questionnaire assessing exposure to childhood trauma, and self-report measures of functional status. We generated indices of social and occupational resilience by regressing childhood trauma exposure on social and occupational functioning, saving the residuals as indices of social and occupational functioning beyond what would be expected given exposure to childhood trauma. Results: Women with lower non-verbal memory evidenced greater social and occupational resilience above and beyond the effects attributable to age, education, HIV status, and depressive and posttraumatic stress symptoms. In addition, women with greater occupational resilience exhibited lower semantic language fluency and processing speed. Conclusion: Results are somewhat consistent with prior studies implicating memory effects in impairment following trauma, though our findings suggest that reduced abilities in these domains may be associated with greater resilience. Studies that use prospective designs and objective assessment of functional status are needed to determine whether non-verbal memory, semantic fluency, and processing speed are implicated in the neural circuitry of post-traumatic exposure resilience.

Published
2017

11. Childhood maltreatment is linked to larger preferred interpersonal distances towards friends and strangers across the globe

Author

Haim-Nachum, S., Sopp, M. R., Lüönd, A. M., Afzal, N., Åhs, Fredrik, Allgaier, A. -K, Arévalo, A., Asongwe, C., Bachem, R., Balle, S. R., Belete, H., Belete Mossie, T., Berzengi, A., Capraz, N., Ceylan, D., Dukes, D., Essadek, A., Fares-Otero, N. E., Halligan, S. L., Hemi, A., Iqbal, N., Jobson, L., Levy-Gigi, E., Martin-Soelch, C., Michael, T., Oe, M., Olff, M., Örnkloo, Helena, Prakash, K., Quaatz, S. M., Raghavan, V., Ramakrishnan, Muniarajan, Reis, D., Şar, V., Schnyder, U., Seedat, S., Shihab, I. N., Vandhana, S., Wadji, D. L., Wamser, R., Zabag, R., Spies, G., Pfaltz, Monique C., Haim-Nachum, S., Sopp, M. R., Lüönd, A. M., Afzal, N., Åhs, Fredrik, Allgaier, A. -K, Arévalo, A., Asongwe, C., Bachem, R., Balle, S. R., Belete, H., Belete Mossie, T., Berzengi, A., Capraz, N., Ceylan, D., Dukes, D., Essadek, A., Fares-Otero, N. E., Halligan, S. L., Hemi, A., Iqbal, N., Jobson, L., Levy-Gigi, E., Martin-Soelch, C., Michael, T., Oe, M., Olff, M., Örnkloo, Helena, Prakash, K., Quaatz, S. M., Raghavan, V., Ramakrishnan, Muniarajan, Reis, D., Şar, V., Schnyder, U., Seedat, S., Shihab, I. N., Vandhana, S., Wadji, D. L., Wamser, R., Zabag, R., Spies, G., and Pfaltz, Monique C.

Abstract

Childhood maltreatment (CM) is thought to be associated with altered responses to social stimuli and interpersonal signals. However, limited evidence exists that CM is linked to larger comfortable interpersonal distance (CID) – the physical distance humans prefer towards others during social interactions. However, no previous study has investigated this association in a comprehensive sample, yielding sufficient statistical power. Moreover, preliminary findings are limited to the European region. Finally, it is unclear how CM affects CID towards different interaction partners, and whether CID is linked to social functioning and attachment. To address these outstanding issues, adults (N = 2986) from diverse cultures and socio-economic strata completed a reaction time task measuring CID towards an approaching stranger and friend. Higher CM was linked to a larger CID towards both friends and strangers. Moreover, insecure attachment and less social support were associated with larger CID. These findings demonstrate for the first time that CM affects CID across countries and cultures, highlighting the robustness of this association.

Published
2024
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15. P.1.j.026 Effects of HIV and childhood trauma on brain morphometry and neurocognitive function

Author

Seedat, S, Spies, G, Ahmed-Leitao, F, Fennema-Notestine, C, and Cherner, M

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Medical Microbiology, Clinical Sciences, Pediatric, Mental Health, Behavioral and Social Science, Infectious Diseases, Biomedical Imaging, Clinical Research, HIV/AIDS, Basic Behavioral and Social Science, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Aged, Attention, Brain Injuries, Case-Control Studies, Caudate Nucleus, Child, Cognitive Dysfunction, Corpus Callosum, Executive Function, Female, Gyrus Cinguli, HIV Infections, Hippocampus, Humans, Magnetic Resonance Imaging, Memory, Short-Term, Motor Skills, Neuropsychological Tests, Putamen, Stress, Psychological, Time Factors, Brain volumetrics, Childhood trauma, FreeSurfer, HIV, MRI, Neurocognition, Virology, Clinical sciences, Medical microbiology
Abstract

A wide spectrum of neurocognitive deficits characterises HIV infection in adults. HIV infection is additionally associated with morphological brain abnormalities affecting neural substrates that subserve neurocognitive function. Early life stress (ELS) also has a direct influence on brain morphology. However, the combined impact of ELS and HIV on brain structure and neurocognitive function has not been examined in an all-female sample with advanced HIV disease. The present study examined the effects of HIV and childhood trauma on brain morphometry and neurocognitive function. Structural data were acquired using a 3T Magnetom MRI scanner, and a battery of neurocognitive tests was administered to 124 women: HIV-positive with ELS (n = 32), HIV-positive without ELS (n = 30), HIV-negative with ELS (n = 31) and HIV-negative without ELS (n = 31). Results revealed significant group volumetric differences for right anterior cingulate cortex (ACC), bilateral hippocampi, corpus callosum, left and right caudate and left and right putamen. Mean regional volumes were lowest in HIV-positive women with ELS compared to all other groups. Although causality cannot be inferred, findings also suggest that alterations in the left frontal lobe, right ACC, left hippocampus, corpus callosum, left and right amygdala and left caudate may be associated with poorer neurocognitive performance in the domains of processing speed, attention/working memory, abstraction/executive functions, motor skills, learning and language/fluency with these effects more pronounced in women living with both HIV and childhood trauma. This study highlights the potential contributory role of childhood trauma to brain alterations and neurocognitive decline in HIV-infected individuals.

Published
2014

18. HPA-axis genes as potential risk variants for neurocognitive decline in trauma-exposed, HIV-positive females

Author

Jacobs S, Moxley K, Womersley JS, Spies G, Hemmings SMJ, and Seedat S

Subjects
Neurocognitive impairment, HIV, Childhood trauma, HPA-axis, CRHBP, CRHR1, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Sean Jacobs, Karis Moxley, Jacqueline S Womersley, Georgina Spies, Sian MJ Hemmings, Soraya Seedat Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa Purpose: Previous studies have independently provided evidence for the effects of HIV infection, hypothalamic–pituitary–adrenal (HPA) axis dysfunction and early life trauma on neurocognitive impairment (NCI). This study examined the interaction between single-nucleotide polymorphisms (SNPs) of two HPA axis genes, corticotrophin-releasing hormone receptor 1 (CRHR1; rs110402, rs242924, rs7209436, and rs4792888) and corticotrophin-releasing hormone-binding protein (CRHBP; rs32897, rs10062367, and rs1053989), childhood trauma, and HIV-associated NCI. Patients and methods: The sample comprised 128 HIV-positive Xhosa females of whom 88 (69%) had a history of childhood trauma. NCI was assessed using a battery of 17 measures sensitive to the effects of HIV, and the history of childhood trauma was assessed using the validated retrospective Childhood Trauma Questionnaire-Short Form. Generalized linear regression models were used to compare allelic distribution by trauma status and global NCI. The association between genotype, childhood trauma, and cognitive scores was also evaluated using generalized linear regression models, assuming additive models for the SNPs, and ANOVA. Results: Of the seven polymorphisms assessed, only the rs10062367 variant of CRHBP was significantly associated with global NCI (P=0.034), independent of childhood trauma. This polymorphism was not significantly associated with z-scores on any specific cognitive domain. The interaction of childhood trauma and variants of CRHR1 was associated with poorer learning (rs110402) and/or recall (rs110402 and rs4792888). Conclusion: These findings suggest that CRHBP rs10062367 A allele is a possible risk variant for NCI in HIV, independent of childhood trauma. Furthermore, results show that the interaction of childhood trauma with variants of CRHR1, rs110402 and rs4792888, confer added vulnerability to NCI in HIV-infected individuals in cognitive domains that are known to be impacted by HIV. While these findings need independent replication in larger samples, it adds CRHBP and CRHR1 to the list of known genes linked to HIV- and childhood trauma-associated neurocognitive phenotypes. Keywords: neurocognitive impairment, HIV, childhood trauma, HPA-axis, CRHBP, CRHR1

Published
2018

19. Perceptions of alcohol use in the context of HIV treatment: a qualitative study

Author

Madhombiro M, Marimbe-Dube B, Dube M, Kaiyo-Utete M, Paradzai A, Chibanda D, Rusakaniko S, van der Watt ASJ, and Seedat S

Subjects
alcohol use, HIV, impact, perceptions, Zimbabwe, Immunologic diseases. Allergy, RC581-607
Abstract

Munyaradzi Madhombiro,1 Bazondlile Marimbe-Dube,1 Michelle Dube,1 Malinda Kaiyo-Utete,1 Angeline Paradzai,2 Dixon Chibanda,1 Simbarashe Rusakaniko,3 ASJ van der Watt,4 Soraya Seedat4 1Department of Psychiatry, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 2Department of Linguistics, University of Zimbabwe, Harare, Zimbabwe; 3Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 4Department of Psychiatry, Stellenbosch University, Cape Town, South Africa Background: Alcohol use is associated with poor HIV treatment outcomes. This study aimed to understand patients’ perceptions of the impact of alcohol use in the context of HIV care. Methods: The study design was a descriptive qualitative study of HIV positive individuals receiving antiretroviral treatment. The study involved four focus group discussions with male and female participants at a tertiary center, city clinic, and rural church. We employed convenience sampling and invited patients coming for their routine visits and medication refills to participate. Results: Participants had an awareness of both the direct and indirect effects of alcohol use. The direct effects related to the incompatibility of HIV medication and alcohol. The indirect effects related to the negative impact of alcohol on treatment adherence. Participants proffered reasons why HIV infected individuals on HIV treatment drink and felt that patients had to make a deliberate choice to stop drinking. Participants displayed some knowledge of interventions for drinking cessation and highlighted the use of pharmacological interventions to stop drinking. Participants indicated that they preferred HIV counselors to provide counseling services in view of the existing relationships that patients had with counselors. Conclusion: People living with HIV have adequate knowledge of the effects of alcohol use in the context of HIV treatment. Stigma and the time taken to engage in an alcohol use intervention appeared to be the main impediments to uptake. The current model of HIV treatment, based on trust with the HIV care team, and maintenance of this trust, could bolster the uptake of an intervention. Involvement of HIV patients in their treatment is necessary to improve treatment outcomes in the context of alcohol use. Keywords: alcohol use, HIV, impact, perceptions, Zimbabwe

Published
2018

20. Prospective interepisodal mood monitoring in patients with affective disorders: a feasibility study

Author

Van der Watt ASJ, Suryapranata APSP, and Seedat S

Subjects
affective disorders, anxiety disorder, bipolar disorder, depression, experiences, mood disorders, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Alberta SJ Van der Watt,1 Alexandra PSP Suryapranata,2 Soraya Seedat1 1Department of Psychiatry, Stellenbosch University, Cape Town, South Africa; 2Internal Medicine, Onze Lieve Vrouwe Gasthuis West, Amsterdam, the Netherlands Objectives: Our primary objective was to assess the feasibility of interepisodal telephonic mood monitoring in patients with affective disorders in a low-resource setting. Secondary objectives included gathering data on longitudinal mood trajectories and assessing patient acceptance of mood monitoring. Methods: Inpatients with a primary mood or anxiety disorder were recruited predischarge. Assessment at intake included demographic information, the Life Events Checklist, and the Childhood Trauma Questionnaire. Participants telephonically completed the Altman Self-Rating Mania Scale (ASRM) and Quick Inventory of Depressive Symptomatology (QIDS), weekly, for 26 weeks. Units of alcohol consumed and life events were recorded. Semi-structured interviews were conducted midway through the mood monitoring protocol. Results: Of the 61 eligible participants (77% female; mean age =35.3 years), 28 completed 26 weeks of telephonic mood monitoring. Thirty-three participants (54.1%) withdrew prematurely or were lost to follow-up. Males were more likely to terminate study participation prematurely. Despite the significant decline in depression scores over 26 weeks, participants endorsed persistent mild-to-moderate depressive symptoms. Statistically, participants who were married/in a relationship had higher mean depression scores throughout the study compared to participants who were single. Throughout the study, ASRM scores were not indicative of significant mania. Suicidality (as measured by QIDS item 12) was highest at Week 3 and Week 12 postdischarge for those who completed 26 weeks of monitoring. Conclusion: Despite the high attrition rate, interepisodal telephonic mood monitoring was deemed to be feasible and it can provide useful information to track progress, encourage medication adherence, and manage early warning signs of relapse. Further research is required to determine the benefit of weekly mood monitoring on mood fluctuations and to examine strategies that enhance retention. Keywords: telephonic, anxiety disorder, bipolar disorder, depression, experiences, mood disorders, mixed method

Published
2018

27. Depression in middle childhood: secure base script as a cognitive diathesis in the relationship between daily stress and depressive symptoms

Author

van Aswegen, T., Seedat, S., van Straten, A., Goossens, L., Bosmans, G., van Aswegen, T., Seedat, S., van Straten, A., Goossens, L., and Bosmans, G.

Abstract

A better understanding of protective factors against childhood depression may allow for the mitigation of severe and chronic symptoms and the timely implementation of intervention strategies. This study investigated the protective effect of having a secure base script on depressive symptoms when children face daily stressors. To test this hypothesis, moderation analyses were performed in a cross-sectional study with 378 children (48.5% boys, 51.5%) aged 8-12 years (M = 10.20; SD = 0.57). The results provided some support for the moderation effect when secure base script knowledge was investigated as a categorical variable in middle childhood. However, the results did not support the moderation effect when investigating secure base script as a continuous variable. Therefore, future investigations may need to address whether a categorical approach could better elucidate the protective role of secure base script knowledge in childhood depression.

Published
2023
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28. DESKTOP ANALYSIS AND QUALITATIVE INVESTIGATION OF PROGRAMMES AND INITIATIVES FOR THE PREVENTION OF AND RESPONSE TO GENDER BASED VIOLENCE AT SOUTH AFRICAN UNIVERSITIES WITH MEDICAL CAMPUSES.

Author

Hewett, M., Butler-Kruger, L., Foflonker, K., Edge, J., Botha, M. H., and Seedat, S.

Subjects
GENDER-based violence, VIOLENCE against women, UNIVERSITIES & colleges, LITERATURE reviews, TRUST, HIGHER education
Abstract

Gender-based violence (GBV) is pervasive at South African higher education institutions (HEIs). Based on a media statement (dated 6 October 2016) by the Department of Higher Education and Training, GBV programmes at HEIs need to be evidence-informed, responsive, contextually relevant, inclusive and person-centred. The present article aims to explore the nature of GBV programmes currently implemented at HEIs in South Africa. A rapid review of the literature, supported by qualitative interviews with representatives of South African HEIs with medical campuses, was conducted. Findings indicate that there is an urgent need to clearly define GBV and to mention it explicitly in policy documents. In addition, research evidence on the effectiveness of prevention and response interventions at HEIs in South Africa is lacking. Challenges highlighted by the HEIs that were surveyed include the lack of trust by staff and students in the response and action plans of the response/task teams at HEIs, uncertainty with regards to the roles of relevant stakeholders and sectors when reporting incidents, as well as insufficient information about what GBV is. This study is intended to provide a baseline for further research evaluating current GBV programmes on medical campuses at HEIs, and highlights the need for an evidence-informed framework of the key ingredients for effective GBV response and prevention programmes. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Global injury morbidity and mortality from 1990 to 2017: Results from the Global Burden of Disease Study 2017

Author

James, S, Castle, C, Dingels, Z, Fox, J, Hamilton, E, Liu, Z, S Roberts, N, Sylte, D, Henry, N, Legrand, K, Abdelalim, A, Abdoli, A, Abdollahpour, I, Abdulkader, R, Abedi, A, Abosetugn, A, Abushouk, A, Adebayo, O, Agudelo-Botero, M, Ahmad, T, Ahmed, R, Ahmed, M, Eddine Aichour, M, Alahdab, F, Alamene, G, Alanezi, F, Alebel, A, Alema, N, Alghnam, S, Al-Hajj, S, Ali, B, Ali, S, Alikhani, M, Alinia, C, Alipour, V, Aljunid, S, Almasi-Hashiani, A, Almasri, N, Altirkawi, K, Abdeldayem Amer, Y, Amini, S, Loreche Amit, A, Andrei, C, Ansari-Moghaddam, A, T Antonio, C, Yaw Appiah, S, Arabloo, J, Arab-Zozani, M, Arefi, Z, Aremu, O, Ariani, F, Arora, A, Asaad, M, Asghari, B, Awoke, N, Ayala Quintanilla, B, Ayano, G, Ayanore, M, Azari, S, Azarian, G, Badawi, A, Badiye, A, Bagli, E, Baig, A, Bairwa, M, Bakhtiari, A, Balachandran, A, Banach, M, Banerjee, S, Banik, P, Banstola, A, Barker-Collo, S, Barnighausen, T, Barrero, L, Barzegar, A, Bayati, M, Baye, B, Bedi, N, Behzadifar, M, Bekuma, T, Belete, H, Benjet, C, Bennett, D, Bensenor, I, Berhe, K, Bhardwaj, P, Bhat, A, Bhattacharyya, K, Bibi, S, Bijani, A, Bin Sayeed, M, Borges, G, Borzi, A, Boufous, S, Brazinova, A, Briko, N, Budhathoki, S, Car, J, Cardenas, R, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castelpietra, G, Catala-Lopez, F, Cerin, E, Chandan, J, Chanie, W, Chattu, S, Chattu, V, Chatziralli, I, Chaudhary, N, Cho, D, Kabir Chowdhury, M, Chu, D, Colquhoun, S, Constantin, M, Costa, V, Damiani, G, Daryani, A, Davila-Cervantes, C, Demeke, F, Demis, A, Demoz, G, Demsie, D, Derakhshani, A, Deribe, K, Desai, R, Nasab, M, Da Silva, D, Dibaji Forooshani, Z, Doyle, K, Driscoll, T, Dubljanin, E, Adema, B, Eagan, A, Eftekhari, A, Ehsani-Chimeh, E, Sayed Zaki, M, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Ellingsen, C, Emamian, M, Endalew, D, Eskandarieh, S, Faris, P, Faro, A, Farzadfar, F, Fatahi, Y, Fekadu, W, Ferede, T, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Feyissa, G, Filip, I, Fischer, F, Folayan, M, Foroutan, M, Francis, J, Franklin, R, Fukumoto, T, Geberemariyam, B, Gebre, A, Gebremedhin, K, Gebremeskel, G, Gebremichael, B, Gedefaw, G, Geta, B, Ghafourifard, M, Ghamari, F, Ghashghaee, A, Gholamian, A, Gill, T, Goulart, A, Grada, A, Grivna, M, Mohialdeen Gubari, M, Guimaraes, R, Guo, Y, Gupta, G, Haagsma, J, Hafezi-Nejad, N, Bidgoli, H, Hall, B, Hamadeh, R, Hamidi, S, Haro, J, Hasan, M, Hasanzadeh, A, Hassanipour, S, Hassankhani, H, Hassen, H, Havmoeller, R, Hayat, K, Hendrie, D, Heydarpour, F, Hijar, M, Ho, H, Hoang, C, Hole, M, Holla, R, Hossain, N, Hosseinzadeh, M, Hostiuc, S, Hu, G, Ibitoye, S, Ilesanmi, O, Ilic, I, Ilic, M, Inbaraj, L, Indriasih, E, Naghibi Irvani, S, Shariful Islam, S, Islam, M, Ivers, R, Jacobsen, K, Jahani, M, Jahanmehr, N, Jakovljevic, M, Jalilian, F, Jayaraman, S, Jayatilleke, A, Jha, R, John-Akinola, Y, Jonas, J, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, A, Kadel, R, Kahsay, A, Kalankesh, L, Kalhor, R, Kamil, T, Kanchan, T, Kapoor, N, Karami, M, Kasaeian, A, Kassaye, H, Kavetskyy, T, Kebede, H, Keiyoro, P, Kelbore, A, Kelkay, B, Khader, Y, Khafaie, M, Khalid, N, Khalil, I, Khalilov, R, Khammarnia, M, Khan, E, Khan, M, Khanna, T, Khazaie, H, Shadmani, F, Khundkar, R, Kiirithio, D, Kim, Y, Kim, D, Kisa, A, Kisa, S, Komaki, H, M Kondlahalli, S, Korshunov, V, Koyanagi, A, G Kraemer, M, Krishan, K, Bicer, B, Kugbey, N, Kumar, V, Kumar, N, Kumar, G, Kumar, M, Kumaresh, G, Kurmi, O, Kuti, O, Vecchia, C, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Laryea, D, Lasrado, S, Latifi, A, Lauriola, P, Leasher, J, Huey Lee, S, Lenjebo, T, Levi, M, Li, S, Linn, S, Liu, X, Lopez, A, Lotufo, P, Lunevicius, R, Lyons, R, Madadin, M, El Razek, M, Mahotra, N, Majdan, M, Majeed, A, Malagon-Rojas, J, Maled, V, Malekzadeh, R, Malta, D, Manafi, N, Manafi, A, Manda, A, Manjunatha, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Maravilla, J, March, L, Mason-Jones, A, Masoumi, S, Massenburg, B, Maulik, P, Meles, G, Melese, A, Melketsedik, Z, N Memiah, P, Mendoza, W, Menezes, R, Mengesha, M, Meretoja, T, Meretoja, A, Merie, H, Mestrovic, T, Miazgowski, B, Miazgowski, T, Miller, T, Mini, G, Mirica, A, Mirrakhimov, E, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Moghadaszadeh, M, Mohamadi, E, Mohammad, Y, Mohammad, K, Darwesh, A, Gholi Mezerji, N, Mohammadian-Hafshejani, A, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohebi, F, Molokhia, M, Monasta, L, Moodley, Y, Moosazadeh, M, Moradi, M, Moradi, G, Moradi-Lakeh, M, Moradpour, F, Morawska, L, Velasquez, I, Morisaki, N, Morrison, S, Mossie, T, Muluneh, A, Murthy, S, Musa, K, Mustafa, G, Nabhan, A, Nagarajan, A, Naik, G, Naimzada, M, Najafi, F, Nangia, V, Nascimento, B, Naserbakht, M, Nayak, V, Ndwandwe, D, Negoi, I, Ngunjiri, J, Nguyen, C, Thi Nguyen, H, Nikbakhsh, R, Anggraini Ningrum, D, Nnaji, C, Nyasulu, P, Ogbo, F, Oghenetega, O, Oh, I, Okunga, E, Olagunju, A, Olagunju, T, Bali, A, Onwujekwe, O, Asante, K, Orpana, H, Ota, E, Otstavnov, N, Otstavnov, S, Mahesh, P, Padubidri, J, Pakhale, S, Pakshir, K, Panda-Jonas, S, Park, E, Patel, S, Pathak, A, Pati, S, Patton, G, Paulos, K, Peden, A, Filipino Pepito, V, Pereira, J, Pham, H, Phillips, M, Pinheiro, M, Polibin, R, Polinder, S, Poustchi, H, Prakash, S, Angga Pribadi, D, Puri, P, Syed, Z, Rabiee, M, Rabiee, N, Radfar, A, Rafay, A, Rafiee, A, Rafiei, A, Rahim, F, Rahimi, S, Rahimi-Movaghar, V, Rahman, M, Rajabpour-Sanati, A, Rajati, F, Rakovac, I, Ranganathan, K, Rao, S, Rashedi, V, Rastogi, P, Rathi, P, Rawaf, S, Rawal, L, Rawassizadeh, R, Renjith, V, N Renzaho, A, Resnikoff, S, Rezapour, A, Ribeiro, A, Rickard, J, Rios Gonzalez, C, Ronfani, L, Roshandel, G, Saad, A, Sabde, Y, Sabour, S, Saddik, B, Safari, S, Safari-Faramani, R, Safarpour, H, Safdarian, M, Sajadi, S, Salamati, P, Salehi, F, Zahabi, S, Rashad Salem, M, Salem, H, Salman, O, Salz, I, Samy, A, Sanabria, J, Riera, L, Santric Milicevic, M, Sarker, A, Sarveazad, A, Sathian, B, Sawhney, M, Sawyer, S, 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Sawhney, M, Sawyer, S, Saxena, S, Sayyah, M, Schwebel, D, Seedat, S, Senthilkumaran, S, Sepanlou, S, Seyedmousavi, S, Sha, F, Shaahmadi, F, Shahabi, S, Shaikh, M, Shams-Beyranvand, M, Shamsizadeh, M, Sharif-Alhoseini, M, Sharifi, H, Sheikh, A, Shigematsu, M, Shin, J, Shiri, R, Siabani, S, Sigfusdottir, I, Singh, P, Singh, J, Sinha, D, Smarandache, C, R Smith, E, Soheili, A, Soleymani, B, Soltanian, A, Soriano, J, Sorrie, M, Soyiri, I, Stein, D, Stokes, M, Sufiyan, M, Rasul Suleria, H, Sykes, B, Tabares-Seisdedos, R, Tabb, K, Taddele, B, Tadesse, D, Tamiru, A, Tarigan, I, Tefera, Y, Tehrani-Banihashemi, A, Tekle, M, Tekulu, G, Tesema, A, Tesfay, B, Thapar, R, Tilahune, A, Tlaye, K, Tohidinik, H, Topor-Madry, R, Tran, B, Tran, K, Tripathy, J, Tsai, A, Car, L, Ullah, S, Ullah, I, Umar, M, Unnikrishnan, B, Upadhyay, E, Uthman, O, Valdez, P, Vasankari, T, Venketasubramanian, N, Violante, F, Vlassov, V, Waheed, Y, Weldesamuel, G, Werdecker, A, Wiangkham, T, Wolde, H, Woldeyes, D, Wondafrash, 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O., Lasrado S., Latifi A., Lauriola P., Leasher J. L., Huey Lee S. W., Lenjebo T. L., Levi M., Li S., Linn S., Liu X., Lopez A. D., Lotufo P. A., Lunevicius R., Lyons R. A., Madadin M., El Razek M. M. A., Mahotra N. B., Majdan M., Majeed A., Malagon-Rojas J. N., Maled V., Malekzadeh R., Malta D. C., Manafi N., Manafi A., Manda A. -L., Manjunatha N., Mansour-Ghanaei F., Mansouri B., Mansournia M. A., Maravilla J. C., March L. M., Mason-Jones A. J., Masoumi S. Z., Massenburg B. B., Maulik P. K., Meles G. G., Melese A., Melketsedik Z. A., N Memiah P. T., Mendoza W., Menezes R. G., Mengesha M. B., Mengesha M. M., Meretoja T. J., Meretoja A., Merie H. E., Mestrovic T., Miazgowski B., Miazgowski T., Miller T. R., Mini G. K., Mirica A., Mirrakhimov E. M., Mirzaei-Alavijeh M., Mithra P., Moazen B., Moghadaszadeh M., Mohamadi E., Mohammad Y., Mohammad K. A., Darwesh A. M., Gholi Mezerji N. M., Mohammadian-Hafshejani A., Mohammadoo-Khorasani M., Mohammadpourhodki R., Mohammed S., Mohammed J. A., Mohebi F., Molokhia M., Monasta L., Moodley Y., Moosazadeh M., Moradi M., Moradi G., Moradi-Lakeh M., Moradpour F., Morawska L., Velasquez I. M., Morisaki N., Morrison S. D., Mossie T. B., Muluneh A. G., Murthy S., Musa K. I., Mustafa G., Nabhan A. F., Nagarajan A. J., Naik G., Naimzada M. D., Najafi F., Nangia V., Nascimento B. R., Naserbakht M., Nayak V., Ndwandwe D. E., Negoi I., Ngunjiri J. W., Nguyen C. T., Thi Nguyen H. L., Nikbakhsh R., Anggraini Ningrum D. N., Nnaji C. A., Nyasulu P. S., Ogbo F. A., Oghenetega O. B., Oh I. -H., Okunga E. W., Olagunju A. T., Olagunju T. O., Bali A. O., Onwujekwe O. E., Asante K. O., Orpana H. M., Ota E., Otstavnov N., Otstavnov S. S., Mahesh P. A., Padubidri J. R., Pakhale S., Pakshir K., Panda-Jonas S., Park E. -K., Patel S. K., Pathak A., Pati S., Patton G. C., Paulos K., Peden A. E., Filipino Pepito V. C., Pereira J., Pham H. Q., Phillips M. R., Pinheiro M., Polibin R. V., Polinder S., Poustchi H., Prakash S., Angga Pribadi D. R., Puri P., Syed Z. Q., Rabiee M., Rabiee N., Radfar A., Rafay A., Rafiee A., Rafiei A., Rahim F., Rahimi S., Rahimi-Movaghar V., Rahman M. A., Rajabpour-Sanati A., Rajati F., Rakovac I., Ranganathan K., Rao S. J., Rashedi V., Rastogi P., Rathi P., Rawaf S., Rawal L., Rawassizadeh R., Renjith V., N Renzaho A. M., Resnikoff S., Rezapour A., Ribeiro A. I., Rickard J., Rios Gonzalez C. M., Ronfani L., Roshandel G., Saad A. M., Sabde Y. D., Sabour S., Saddik B., Safari S., Safari-Faramani R., Safarpour H., Safdarian M., Sajadi S. M., Salamati P., Salehi F., Zahabi S. S., Rashad Salem M. R., Salem H., Salman O., Salz I., Samy A. M., Sanabria J., Riera L. S., Santric Milicevic M. M., Sarker A. R., Sarveazad A., Sathian B., Sawhney M., Sawyer S. M., Saxena S., Sayyah M., Schwebel D. C., Seedat S., Senthilkumaran S., Sepanlou S. G., Seyedmousavi S., Sha F., Shaahmadi F., Shahabi S., Shaikh M. A., Shams-Beyranvand M., Shamsizadeh M., Sharif-Alhoseini M., Sharifi H., Sheikh A., Shigematsu M., Shin J. I., Shiri R., Siabani S., Sigfusdottir I. D., Singh P. K., Singh J. A., Sinha D. N., Smarandache C. -G., R Smith E. U., Soheili A., Soleymani B., Soltanian A. R., Soriano J. B., Sorrie M. B., Soyiri I. N., Stein D. J., Stokes M. A., Sufiyan M. B., Rasul Suleria H. A., Sykes B. L., Tabares-Seisdedos R., Tabb K. M., Taddele B. W., Tadesse D. B., Tamiru A. T., Tarigan I. U., Tefera Y. M., Tehrani-Banihashemi A., Tekle M. G., Tekulu G. H., Tesema A. K., Tesfay B. E., Thapar R., Tilahune A. B., Tlaye K. G., Tohidinik H. R., Topor-Madry R., Tran B. X., Tran K. B., Tripathy J. P., Tsai A. C., Car L. T., Ullah S., Ullah I., Umar M., Unnikrishnan B., Upadhyay E., Uthman O. A., Valdez P. R., Vasankari T. J., Venketasubramanian N., Violante F. S., Vlassov V., Waheed Y., Weldesamuel G. T., Werdecker A., Wiangkham T., Wolde H. F., Woldeyes D. H., Wondafrash D. Z., Wondmeneh T. G., Wondmieneh A. B., Wu A. -M., Yadav R., Yadollahpour A., Yano Y., Yaya S., Yazdi-Feyzabadi V., Yip P., Yisma E., Yonemoto N., Yoon S. -J., Youm Y., Younis M. Z., Yousefi Z., Yu Y., Yu C., Yusefzadeh H., Moghadam T. Z., Zaidi Z., Zaman S. B., Zamani M., Zamanian M., Zandian H., Zarei A., Zare F., Zhang Z. -J., Zhang Y., Zodpey S., Dandona L., Dandona R., Degenhardt L., Dharmaratne S. D., Hay S. I., Mokdad A. H., Reiner Jr R. C., Sartorius B., and Vos T.

Abstract

Background: Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods: We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings: In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation: Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.

Published
2020

34. Enhancing discovery of genetic variants for PTSD through integration of quantitative phenotypes and trauma exposure information

Author

Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Borglum, Anders D., Babic, Dragan, Bkvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, J.M., Chen, Chia-Yen, Dale, Anders M., Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Kulenovic, Alma Dzubur, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goci, Aferdita, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue-Jun, Karstoft, Karen-Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Bozo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, D., Mavissakalian, Matig R., McFarlane, Alexander, McGlinchey, Regina E., McLaughlin, Katie A., McLean, Samuel A., Mehta, Divya, Mellor, Rebecca, Michopoulos, Vasiliki, Milberg, William, Miller, Mark W., Morris, Charles Phillip, Mors, Ole, Mortensen, P.B., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., O'Donnell, Meaghan, Orcutt, Holly K., Panizzon, Matthew S., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Rice, John P., Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, P., Ruggiero, Kenneth J., Rung, Ariane, Rutten, Bart P.F., Saccone, Nancy L., Sanchez, Sixto E., Schijven, Dick, Seedat, S., Seligowski, Antonia V., Seng, Julia S., Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stevens, Jennifer S., Teicher, Martin H., Thompson, Wesley K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Luella van den Heuvel, Leigh, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan, Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Yehuda, Rachel, Young, Keith A., Young, Ross McD., Zhao, Hongyu, Zoellner, Lori A., Haas, Magali, Lasseter, Heather, Provost, Allison C., Salem, Rany M., Sebat, Jonathan, Shaffer, Richard A., Wu, Tianying, Ripke, Stephan, Daly, Mark J., Ressler, Kerry J., Koenen, Karestan C., Stein, Murray B., and Nievergelt, Caroline M.

Subjects
trauma, mental disorders, PheWAS, GWAS, PTSD, genetics, heritability, behavioral disciplines and activities
Abstract

Background\ud Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWAS).\ud Methods\ud GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European Ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with LD-score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program (MVP) GWAS of PTSD total symptoms.\ud Results\ud GWAS of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four out of these 9 PTSD loci were independently replicated in MVP.\ud Conclusion\ud Through using a quantitative trait measure of PTSD, we identify novel risk loci not previously identified using prior case/control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.

Published
2022

35. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce

Author

Sarris, J., Ravindran, A., Yatham, L.N., Marx, W., Rucklidge, J.J., McIntyre, R.S., Akhondzadeh, S., Benedetti, F., Caneo, C., Cramer, H., Cribb, L., de Manincor, M., Dean, O., Deslandes, A.C., Freeman, M.P., Gangadhar, B., Harvey, B.H., Kasper, S., Lake, J., Lopresti, A., Lu, L., Metri, N-J, Mischoulon, D., Ng, C.H., Nishi, D., Rahimi, R., Seedat, S., Sinclair, J., Su, K-P, Zhang, Z-J, Berk, M., Sarris, J., Ravindran, A., Yatham, L.N., Marx, W., Rucklidge, J.J., McIntyre, R.S., Akhondzadeh, S., Benedetti, F., Caneo, C., Cramer, H., Cribb, L., de Manincor, M., Dean, O., Deslandes, A.C., Freeman, M.P., Gangadhar, B., Harvey, B.H., Kasper, S., Lake, J., Lopresti, A., Lu, L., Metri, N-J, Mischoulon, D., Ng, C.H., Nishi, D., Rahimi, R., Seedat, S., Sinclair, J., Su, K-P, Zhang, Z-J, and Berk, M.

Abstract

Objectives The therapeutic use of nutrient-based ‘nutraceuticals’ and plant-based ‘phytoceuticals’ for the treatment of mental disorders is common; however, despite recent research progress, there have not been any updated global clinical guidelines since 2015. To address this, the World Federation of Societies of Biological Psychiatry (WFSBP) and the Canadian Network for Mood and Anxiety Disorders (CANMAT) convened an international taskforce involving 31 leading academics and clinicians from 15 countries, between 2019 and 2021. These guidelines are aimed at providing a definitive evidence-informed approach to assist clinicians in making decisions around the use of such agents for major psychiatric disorders. We also provide detail on safety and tolerability, and clinical advice regarding prescription (e.g. indications, dosage), in addition to consideration for use in specialised populations. Methods The methodology was based on the WFSBP guidelines development process. Evidence was assessed based on the WFSBP grading of evidence (and was modified to focus on Grade A level evidence – meta-analysis or two or more RCTs – due to the breadth of data available across all nutraceuticals and phytoceuticals across major psychiatric disorders). The taskforce assessed both the ‘level of evidence’ (LoE) (i.e. meta-analyses or RCTs) and the assessment of the direction of the evidence, to determine whether the intervention was ‘Recommended’ (+++), ‘Provisionally Recommended’ (++), ‘Weakly Recommended’ (+), ‘Not Currently Recommended’ (+/−), or ‘Not Recommended’ (−) for a particular condition. Due to the number of clinical trials now available in the field, we firstly examined the data from our two meta-reviews of meta-analyses (nutraceuticals conducted in 2019, and phytoceuticals in 2020). We then performed a search of additional relevant RCTs and reported on both these data as the primary drivers supporting our clinical recommendations. Lower levels of evidence, including isola

Published
2022

36. Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A)

Author

Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, Marx, Wolf, Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, and Marx, Wolf

Published
2022

37. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic

Author

Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, Berk, Michael, Solmi, M, Estradé, A, Thompson, T, Agorastos, A, Radua, J, Cortese, S, Dragioti, E, Leisch, F, Vancampfort, D, Thygesen, LC, Aschauer, H, Schloegelhofer, M, Akimova, E, Schneeberger, A, Huber, CG, Hasler, G, Conus, P, Cuénod, KQD, von Känel, R, Arrondo, G, Fusar-Poli, P, Gorwood, P, Llorca, PM, Krebs, MO, Scanferla, E, Kishimoto, T, Rabbani, G, Skonieczna-Żydecka, K, Brambilla, P, Favaro, A, Takamiya, A, Zoccante, L, Colizzi, M, Bourgin, J, Kamiński, K, Moghadasin, M, Seedat, S, Matthews, E, Wells, J, Vassilopoulou, E, Gadelha, A, Su, KP, Kwon, JS, Kim, M, Lee, TY, Papsuev, O, Manková, D, Boscutti, A, Gerunda, C, Saccon, D, Righi, E, Monaco, F, Croatto, G, Cereda, G, Demurtas, J, Brondino, N, Veronese, N, Enrico, P, Politi, P, Ciappolino, V, Pfennig, A, Bechdolf, A, Meyer-Lindenberg, A, Kahl, KG, Domschke, K, Bauer, M, Koutsouleris, N, Winter, S, Borgwardt, S, Bitter, I, Balazs, J, Czobor, P, Unoka, Z, Mavridis, D, Tsamakis, K, Bozikas, VP, Tunvirachaisakul, C, Maes, M, Rungnirundorn, T, Supasitthumrong, T, Haque, A, Brunoni, AR, Costardi, CG, Schuch, FB, Polanczyk, G, Luiz, JM, Fonseca, L, Aparicio, LV, Valvassori, SS, Nordentoft, M, Vendsborg, P, Hoffmann, SH, Sehli, J, Sartorius, N, Heuss, S, Guinart, D, Hamilton, J, Kane, J, Rubio, J, Sand, M, and Berk, Michael

Published
2022

38. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce

Author

Sarris, J, Ravindran, A, Yatham, LN, Marx, Wolf, Rucklidge, JJ, McIntyre, RS, Akhondzadeh, S, Benedetti, F, Caneo, C, Cramer, H, Cribb, L, de Manincor, M, Dean, Olivia, Deslandes, AC, Freeman, MP, Gangadhar, B, Harvey, BH, Kasper, S, Lake, J, Lopresti, A, Lu, L, Metri, NJ, Mischoulon, D, Ng, CH, Nishi, D, Rahimi, R, Seedat, S, Sinclair, J, Su, KP, Zhang, ZJ, Berk, Michael, Sarris, J, Ravindran, A, Yatham, LN, Marx, Wolf, Rucklidge, JJ, McIntyre, RS, Akhondzadeh, S, Benedetti, F, Caneo, C, Cramer, H, Cribb, L, de Manincor, M, Dean, Olivia, Deslandes, AC, Freeman, MP, Gangadhar, B, Harvey, BH, Kasper, S, Lake, J, Lopresti, A, Lu, L, Metri, NJ, Mischoulon, D, Ng, CH, Nishi, D, Rahimi, R, Seedat, S, Sinclair, J, Su, KP, Zhang, ZJ, and Berk, Michael

Published
2022

39. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Author

Maihofer, AX, Choi, KW, Coleman, JR, Daskalakis, NP, Denckla, CA, Ketema, E, Morey, RA, Polimanti, R, Ratanatharathorn, A, Torres, K, Wingo, AP, Zai, CC, Aiello, AE, Almli, LM, Amstadter, AB, Andersen, SB, Andreassen, OA, Arbisi, PA, Ashley-Koch, AE, Austin, SB, Avdibegovic, E, Borglum, AD, Babic, D, Baekvad-Hansen, M, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Boks, MP, Bolger, EA, Bradley, B, Brashear, M, Breen, G, Bryant, RA, Bustamante, AC, Bybjerg-Grauholm, J, Calabrese, JR, Caldas-de-Almeida, JM, Chen, C-Y, Dale, AM, Dalvie, S, Deckert, J, Delahanty, DL, Dennis, MF, Disner, SG, Domschke, K, Duncan, LE, Kulenovic, AD, Erbes, CR, Evans, A, Farrer, LA, Feeny, NC, Flory, JD, Forbes, D, Franz, CE, Galea, S, Garrett, ME, Gautam, A, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, CF, Goci, A, Gordon, SD, Guffanti, G, Hammamieh, R, Hauser, MA, Heath, AC, Hemmings, SMJ, Hougaard, DM, Jakovljevic, M, Jett, M, Johnson, EO, Jones, I, Jovanovic, T, Qin, X-J, Karstoft, K-I, Kaufman, ML, Kessler, RC, Khan, A, Kimbrel, NA, King, AP, Koen, N, Kranzler, HR, Kremen, WS, Lawford, BR, Lebois, LAM, Lewis, C, Liberzon, I, Linnstaedt, SD, Logue, MW, Lori, A, Lugonja, B, Luykx, JJ, Lyons, MJ, Maples-Keller, JL, Marmar, C, Martin, NG, Maurer, D, Mavissakalian, MR, McFarlane, A, McGlinchey, RE, McLaughlin, KA, McLean, SA, Mehta, D, Mellor, R, Michopoulos, V, Milberg, W, Miller, MW, Morris, CP, Mors, O, Mortensen, PB, Nelson, EC, Nordentoft, M, Norman, SB, O'Donnell, M, Orcutt, HK, Panizzon, MS, Peters, ES, Peterson, AL, Peverill, M, Pietrzak, RH, Polusny, MA, Rice, JP, Risbrough, VB, Roberts, AL, Rothbaum, AO, Rothbaum, BO, Roy-Byrne, P, Ruggiero, KJ, Rung, A, Rutten, BPF, Saccone, NL, Sanchez, SE, Schijven, D, Seedat, S, Seligowski, A, Seng, JS, Sheerin, CM, Silove, D, Smith, AK, Smoller, JW, Sponheim, SR, Stein, DJ, Stevens, JS, Teicher, MH, Thompson, WK, Trapido, E, Uddin, M, Ursano, RJ, van den Heuvel, LL, Van Hooff, M, Vermetten, E, Vinkers, CH, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, MA, Williamson, DE, Winternitz, S, Wolf, C, Wolf, EJ, Yehuda, R, Young, KA, Young, RM, Zhao, H, Zoellner, LA, Haas, M, Lasseter, H, Provost, AC, Salem, RM, Sebat, J, Shaffer, RA, Wu, T, Ripke, S, Daly, MJ, Ressler, KJ, Koenen, KC, Stein, MB, Nievergelt, CM, Maihofer, AX, Choi, KW, Coleman, JR, Daskalakis, NP, Denckla, CA, Ketema, E, Morey, RA, Polimanti, R, Ratanatharathorn, A, Torres, K, Wingo, AP, Zai, CC, Aiello, AE, Almli, LM, Amstadter, AB, Andersen, SB, Andreassen, OA, Arbisi, PA, Ashley-Koch, AE, Austin, SB, Avdibegovic, E, Borglum, AD, Babic, D, Baekvad-Hansen, M, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Boks, MP, Bolger, EA, Bradley, B, Brashear, M, Breen, G, Bryant, RA, Bustamante, AC, Bybjerg-Grauholm, J, Calabrese, JR, Caldas-de-Almeida, JM, Chen, C-Y, Dale, AM, Dalvie, S, Deckert, J, Delahanty, DL, Dennis, MF, Disner, SG, Domschke, K, Duncan, LE, Kulenovic, AD, Erbes, CR, Evans, A, Farrer, LA, Feeny, NC, Flory, JD, Forbes, D, Franz, CE, Galea, S, Garrett, ME, Gautam, A, Gelaye, B, Gelernter, J, Geuze, E, Gillespie, CF, Goci, A, Gordon, SD, Guffanti, G, Hammamieh, R, Hauser, MA, Heath, AC, Hemmings, SMJ, Hougaard, DM, Jakovljevic, M, Jett, M, Johnson, EO, Jones, I, Jovanovic, T, Qin, X-J, Karstoft, K-I, Kaufman, ML, Kessler, RC, Khan, A, Kimbrel, NA, King, AP, Koen, N, Kranzler, HR, Kremen, WS, Lawford, BR, Lebois, LAM, Lewis, C, Liberzon, I, Linnstaedt, SD, Logue, MW, Lori, A, Lugonja, B, Luykx, JJ, Lyons, MJ, Maples-Keller, JL, Marmar, C, Martin, NG, Maurer, D, Mavissakalian, MR, McFarlane, A, McGlinchey, RE, McLaughlin, KA, McLean, SA, Mehta, D, Mellor, R, Michopoulos, V, Milberg, W, Miller, MW, Morris, CP, Mors, O, Mortensen, PB, Nelson, EC, Nordentoft, M, Norman, SB, O'Donnell, M, Orcutt, HK, Panizzon, MS, Peters, ES, Peterson, AL, Peverill, M, Pietrzak, RH, Polusny, MA, Rice, JP, Risbrough, VB, Roberts, AL, Rothbaum, AO, Rothbaum, BO, Roy-Byrne, P, Ruggiero, KJ, Rung, A, Rutten, BPF, Saccone, NL, Sanchez, SE, Schijven, D, Seedat, S, Seligowski, A, Seng, JS, Sheerin, CM, Silove, D, Smith, AK, Smoller, JW, Sponheim, SR, Stein, DJ, Stevens, JS, Teicher, MH, Thompson, WK, Trapido, E, Uddin, M, Ursano, RJ, van den Heuvel, LL, Van Hooff, M, Vermetten, E, Vinkers, CH, Voisey, J, Wang, Y, Wang, Z, Werge, T, Williams, MA, Williamson, DE, Winternitz, S, Wolf, C, Wolf, EJ, Yehuda, R, Young, KA, Young, RM, Zhao, H, Zoellner, LA, Haas, M, Lasseter, H, Provost, AC, Salem, RM, Sebat, J, Shaffer, RA, Wu, T, Ripke, S, Daly, MJ, Ressler, KJ, Koenen, KC, Stein, MB, and Nievergelt, CM

Abstract

BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. RESULTS: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. CONCLUSIONS: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.

Published
2022

40. Changes in telepsychiatry regulations during the COVID-19 pandemic: 17 countries and regions' approaches to an evolving healthcare landscape

Author

Kinoshita, S, Cortright, K, Crawford, A, Mizuno, Y, Yoshida, K, Hilty, D, Guinart, D, Torous, J, Correll, CU, Castle, DJ, Rocha, D, Yang, Y, Xiang, Y-T, Kolbaek, P, Dines, D, ElShami, M, Jain, P, Kallivayalil, R, Solmi, M, Favaro, A, Veronese, N, Seedat, S, Shin, S, Salazar de Pablo, G, Chang, C-H, Su, K-P, Karas, H, Kane, JM, Yellowlees, P, Kishimoto, T, Kinoshita, S, Cortright, K, Crawford, A, Mizuno, Y, Yoshida, K, Hilty, D, Guinart, D, Torous, J, Correll, CU, Castle, DJ, Rocha, D, Yang, Y, Xiang, Y-T, Kolbaek, P, Dines, D, ElShami, M, Jain, P, Kallivayalil, R, Solmi, M, Favaro, A, Veronese, N, Seedat, S, Shin, S, Salazar de Pablo, G, Chang, C-H, Su, K-P, Karas, H, Kane, JM, Yellowlees, P, and Kishimoto, T

Abstract

BACKGROUND: During the COVID-19 pandemic, the use of telemedicine as a way to reduce COVID-19 infections was noted and consequently deregulated. However, the degree of telemedicine regulation varies from country to country, which may alter the widespread use of telemedicine. This study aimed to clarify the telepsychiatry regulations for each collaborating country/region before and during the COVID-19 pandemic. METHODS: We used snowball sampling within a global network of international telepsychiatry experts. Thirty collaborators from 17 different countries/regions responded to a questionnaire on barriers to the use and implementation of telepsychiatric care, including policy factors such as regulations and reimbursement at the end of 2019 and as of May 2020. RESULTS: Thirteen of 17 regions reported a relaxation of regulations due to the pandemic; consequently, all regions surveyed stated that telepsychiatry was now possible within their public healthcare systems. In some regions, restrictions on prescription medications allowed via telepsychiatry were eased, but in 11 of the 17 regions, there were still restrictions on prescribing medications via telepsychiatry. Lower insurance reimbursement amounts for telepsychiatry consultations v. in-person consultations were reevaluated in four regions, and consequently, in 15 regions telepsychiatry services were reimbursed at the same rate (or higher) than in-person consultations during the COVID-19 pandemic. CONCLUSIONS: Our results confirm that, due to COVID-19, the majority of countries surveyed are altering telemedicine regulations that had previously restricted the spread of telemedicine. These findings provide information that could guide future policy and regulatory decisions, which facilitate greater scale and spread of telepsychiatry globally.

Published
2022

41. Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019

Author

Haakenstad, A., Irvine, C.M.S., Knight, M., Bintz, C., Aravkin, A.Y., Zheng, P., Gupta, V., Abrigo, M.R.M., Abushouk, A.I., Adebayo, O.M., Agarwal, G., Alahdab, F., Al-Aly, Z., Alam, K., Alanzi, T.M., Alcalde-Rabanal, J.E., Alipour, V., Alvis-Guzman, N., Amit, A.M.L., Andrei, C.L., Andrei, T., Antonio, C.A.T., Arabloo, J., Aremu, O., Ayanore, M.A., Banach, M., Bärnighausen, T.W., Barthelemy, C.M., Bayati, M., Benzian, H., Berman, A.E., Bienhoff, K., Bijani, A., Bikbov, B., Biondi, A., Boloor, A., Busse, R., Butt, Z.A., Cámera, L.A., Campos-Nonato, I.R., Cárdenas, R., Carvalho, F., Chansa, C., Chattu, S.K., Chattu, V.K., Chu, D-T, Dai, X., Dandona, L., Dandona, R., Dangel, W.J., Daryani, A., De Neve, J-W, Dhimal, M., Dipeolu, I.O., Djalalinia, S., Do, H.T., Doshi, C.P., Doshmangir, L., Ehsani-Chimeh, E., El Tantawi, M., Fernandes, E., Fischer, F., Foigt, N.A., Fomenkov, A.A., Foroutan, M., Fukumoto, T., Fullman, N., Gad, M.M., Ghadiri, K., Ghafourifard, M., Ghashghaee, A., Glucksman, T., Goudarzi, H., Gupta, R.D., Hamadeh, R.R., Hamidi, S., Haro, J.M., Hasanpoor, E., Hay, S.I., Hegazy, M.I., Heibati, B., Henry, N.J., Hole, M.K., Hossain, N., Househ, M., Ilesanmi, O.S., Imani-Nasab, M-H, Irvani, S.S.N., Islam, S.M.S., Jahani, M.A., Joshi, A., Kalhor, R., Kayode, G.A., Khalid, N., Khatab, K., Kisa, A., Kochhar, S., Krishan, K., Kuate Defo, B., Lal, D.K., Lami, F.H., Larsson, A.O., Leasher, J.L., LeGrand, K.E., Lim, L-L, Mahotra, N.B., Majeed, A., Maleki, A., Manjunatha, N., Massenburg, B.B., Mestrovic, T., Mini, G.K., Mirica, A., Mirrakhimov, E.M., Mohammad, Y., Mohammed, S., Mokdad, A.H., Morrison, S.D., Naghavi, M., Ndwandwe, D.E., Negoi, I., Negoi, R.I., Ngunjiri, J.W., Nguyen, C.T., Nigatu, Y.T., Onwujekwe, O.E., Ortega-Altamirano, D.V., Otstavnov, N., Otstavnov, S.S., Owolabi, M.O., Pakhare, A.P., Pepito, V.C.F., Perico, N., Pham, H.Q., Pigott, D.M., Pokhrel, K.N., Rabiee, M., Rabiee, N., Rahimi-Movaghar, V., Rawaf, D.L., Rawaf, S., Rawal, L., Remuzzi, G., Renzaho, A.M.N., Resnikoff, S., Rezaei, N., Rezapour, A., Rickard, J., Roever, L., Sahu, M., Samy, A.M., Sanabria, J., Santric-Milicevic, M.M., Saraswathy, S.Y.I., Seedat, S., Senthilkumaran, S., Serván-Mori, E., Shaikh, M.A., Sheikh, A., Silva, D.A.S., Stein, C., Stein, D.J., Titova, M.V., Topp, S.M., Tovani-Palone, M.R., Ullah, S., Unnikrishnan, B., Vacante, M., Valdez, P.R., Vasankari, T.J., Venketasubramanian, N., Vlassov, V., Vos, T., Yearwood, J.A., Yonemoto, N., Younis, M.Z., Yu, C., Zadey, S., Zaman, S.B., Zerfu, T.A., Zhang, Z-J, Ziapour, A., Zodpey, S., Lim, S.S., Murray, C.J.L., Lozano, R., Haakenstad, A., Irvine, C.M.S., Knight, M., Bintz, C., Aravkin, A.Y., Zheng, P., Gupta, V., Abrigo, M.R.M., Abushouk, A.I., Adebayo, O.M., Agarwal, G., Alahdab, F., Al-Aly, Z., Alam, K., Alanzi, T.M., Alcalde-Rabanal, J.E., Alipour, V., Alvis-Guzman, N., Amit, A.M.L., Andrei, C.L., Andrei, T., Antonio, C.A.T., Arabloo, J., Aremu, O., Ayanore, M.A., Banach, M., Bärnighausen, T.W., Barthelemy, C.M., Bayati, M., Benzian, H., Berman, A.E., Bienhoff, K., Bijani, A., Bikbov, B., Biondi, A., Boloor, A., Busse, R., Butt, Z.A., Cámera, L.A., Campos-Nonato, I.R., Cárdenas, R., Carvalho, F., Chansa, C., Chattu, S.K., Chattu, V.K., Chu, D-T, Dai, X., Dandona, L., Dandona, R., Dangel, W.J., Daryani, A., De Neve, J-W, Dhimal, M., Dipeolu, I.O., Djalalinia, S., Do, H.T., Doshi, C.P., Doshmangir, L., Ehsani-Chimeh, E., El Tantawi, M., Fernandes, E., Fischer, F., Foigt, N.A., Fomenkov, A.A., Foroutan, M., Fukumoto, T., Fullman, N., Gad, M.M., Ghadiri, K., Ghafourifard, M., Ghashghaee, A., Glucksman, T., Goudarzi, H., Gupta, R.D., Hamadeh, R.R., Hamidi, S., Haro, J.M., Hasanpoor, E., Hay, S.I., Hegazy, M.I., Heibati, B., Henry, N.J., Hole, M.K., Hossain, N., Househ, M., Ilesanmi, O.S., Imani-Nasab, M-H, Irvani, S.S.N., Islam, S.M.S., Jahani, M.A., Joshi, A., Kalhor, R., Kayode, G.A., Khalid, N., Khatab, K., Kisa, A., Kochhar, S., Krishan, K., Kuate Defo, B., Lal, D.K., Lami, F.H., Larsson, A.O., Leasher, J.L., LeGrand, K.E., Lim, L-L, Mahotra, N.B., Majeed, A., Maleki, A., Manjunatha, N., Massenburg, B.B., Mestrovic, T., Mini, G.K., Mirica, A., Mirrakhimov, E.M., Mohammad, Y., Mohammed, S., Mokdad, A.H., Morrison, S.D., Naghavi, M., Ndwandwe, D.E., Negoi, I., Negoi, R.I., Ngunjiri, J.W., Nguyen, C.T., Nigatu, Y.T., Onwujekwe, O.E., Ortega-Altamirano, D.V., Otstavnov, N., Otstavnov, S.S., Owolabi, M.O., Pakhare, A.P., Pepito, V.C.F., Perico, N., Pham, H.Q., Pigott, D.M., Pokhrel, K.N., Rabiee, M., Rabiee, N., Rahimi-Movaghar, V., Rawaf, D.L., Rawaf, S., Rawal, L., Remuzzi, G., Renzaho, A.M.N., Resnikoff, S., Rezaei, N., Rezapour, A., Rickard, J., Roever, L., Sahu, M., Samy, A.M., Sanabria, J., Santric-Milicevic, M.M., Saraswathy, S.Y.I., Seedat, S., Senthilkumaran, S., Serván-Mori, E., Shaikh, M.A., Sheikh, A., Silva, D.A.S., Stein, C., Stein, D.J., Titova, M.V., Topp, S.M., Tovani-Palone, M.R., Ullah, S., Unnikrishnan, B., Vacante, M., Valdez, P.R., Vasankari, T.J., Venketasubramanian, N., Vlassov, V., Vos, T., Yearwood, J.A., Yonemoto, N., Younis, M.Z., Yu, C., Zadey, S., Zaman, S.B., Zerfu, T.A., Zhang, Z-J, Ziapour, A., Zodpey, S., Lim, S.S., Murray, C.J.L., and Lozano, R.

Abstract

Background Human resources for health (HRH) include a range of occupations that aim to promote or improve human health. The UN Sustainable Development Goals (SDGs) and the WHO Health Workforce 2030 strategy have drawn attention to the importance of HRH for achieving policy priorities such as universal health coverage (UHC). Although previous research has found substantial global disparities in HRH, the absence of comparable cross-national estimates of existing workforces has hindered efforts to quantify workforce requirements to meet health system goals. We aimed to use comparable and standardised data sources to estimate HRH densities globally, and to examine the relationship between a subset of HRH cadres and UHC effective coverage performance. Methods Through the International Labour Organization and Global Health Data Exchange databases, we identified 1404 country-years of data from labour force surveys and 69 country-years of census data, with detailed microdata on health-related employment. From the WHO National Health Workforce Accounts, we identified 2950 country-years of data. We mapped data from all occupational coding systems to the International Standard Classification of Occupations 1988 (ISCO-88), allowing for standardised estimation of densities for 16 categories of health workers across the full time series. Using data from 1990 to 2019 for 196 of 204 countries and territories, covering seven Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) super-regions and 21 regions, we applied spatiotemporal Gaussian process regression (ST-GPR) to model HRH densities from 1990 to 2019 for all countries and territories. We used stochastic frontier meta-regression to model the relationship between the UHC effective coverage index and densities for the four categories of health workers enumerated in SDG indicator 3.c.1 pertaining to HRH: physicians, nurses and midwives, dentistry personnel, and pharmaceutical personnel. We identified minimum workfor

Published
2022

42. Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Haakenstad, A, Irvine, CMS, Knight, M, Bintz, C, Aravkin, AY, Zheng, P, Gupta, V, Abrigo, MRM, Abushouk, A, Adebayo, OM, Agarwal, G, Alahdab, F, Al-Aly, Z, Alam, K, Alanzi, TM, Alcalde-Rabanal, JE, Alipour, V, Alvis-Guzman, N, Amit, AML, Liliana Andrei, C, Andrei, T, Antonio, CAT, Arabloo, J, Aremu, O, Ayanore, MA, Banach, M, Barnighausen, TW, Barthelemy, CM, Bayati, M, Benzian, H, Berman, AE, Bienhoff, K, Bijani, A, Bikbov, B, Biondi, A, Boloor, A, Busse, R, Butt, ZA, Camera, LA, Campos-Nonato, IR, Cardenas, R, Carvalho, F, Chansa, C, Chattu, SK, Chattu, VK, Chu, D-T, Dai, X, Dandona, L, Dandona, R, Dangel, WJ, Daryani, A, De Neve, J-W, Dhimal, M, Dipeolu, IO, Djalalinia, S, Hoa, TD, Doshi, CP, Doshmangir, L, Ehsani-Chimeh, E, El Tantawi, M, Fernandes, E, Fischer, F, Foigt, NA, Fomenkov, AA, Foroutan, M, Fukumoto, T, Fullman, N, Gad, MM, Ghadiri, K, Ghafourifard, M, Ghashghaee, A, Glucksman, T, Goudarzi, H, Das Gupta, R, Hamadeh, RR, Hamidi, S, Haro, JM, Hasanpoor, E, Hay, S, Hegazy, M, Heibati, B, Henry, NJ, Hole, MK, Hossain, N, Househ, M, Ilesanmi, OS, Imani-Nasab, M-H, Irvani, SSN, Islam, SMS, Jahani, MA, Joshi, A, Kalhor, R, Kayode, GA, Khalid, N, Khatab, K, Kisa, A, Kochhar, S, Krishan, K, Defo, BK, Lal, DK, Lami, FH, Larsson, AO, Leasher, JL, LeGrand, KE, Lim, L-L, Mahotra, NB, Majeed, A, Maleki, A, Manjunatha, N, Massenburg, BB, Mestrovic, T, Mini, GK, Mirica, A, Mirrakhimov, EM, Mohammad, Y, Mohammed, S, Mokdad, AH, Morrison, SD, Naghavi, M, Ndwandwe, DE, Negoi, I, Negoi, RI, Ngunjiri, JW, Cuong, TN, Nigatu, YT, Onwujekwe, OE, Ortega-Altamirano, D, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Pakhare, AP, Filipino Pepito, VC, Perico, N, Pham, HQ, Pigott, DM, Pokhrel, KN, Rabiee, M, Rabiee, N, Rahimi-Movaghar, V, Rawaf, DL, Rawaf, S, Rawal, L, Remuzzi, G, Renzaho, AMN, Resnikoff, S, Rezaei, N, Rezapour, A, Rickard, J, Roever, L, Sahu, M, Samy, AM, Sanabria, J, Santric-Milicevic, MM, Saraswathy, SYI, Seedat, S, Senthilkumaran, S, Servan-Mori, E, Shaikh, MA, Sheikh, A, Silva, DAS, Stein, C, Stein, DJ, Titova, MV, Topp, SM, Tovani-Palone, MR, Ullah, S, Unnikrishnan, B, Vacante, M, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Vlassov, V, Vos, T, Yearwood, JA, Yonemoto, N, Younis, MZ, Yu, C, Zadey, S, Bin Zaman, S, Zerfu, TA, Zhang, Z-J, Ziapour, A, Zodpey, S, Lim, SS, Murray, CJL, Lozano, R, Haakenstad, A, Irvine, CMS, Knight, M, Bintz, C, Aravkin, AY, Zheng, P, Gupta, V, Abrigo, MRM, Abushouk, A, Adebayo, OM, Agarwal, G, Alahdab, F, Al-Aly, Z, Alam, K, Alanzi, TM, Alcalde-Rabanal, JE, Alipour, V, Alvis-Guzman, N, Amit, AML, Liliana Andrei, C, Andrei, T, Antonio, CAT, Arabloo, J, Aremu, O, Ayanore, MA, Banach, M, Barnighausen, TW, Barthelemy, CM, Bayati, M, Benzian, H, Berman, AE, Bienhoff, K, Bijani, A, Bikbov, B, Biondi, A, Boloor, A, Busse, R, Butt, ZA, Camera, LA, Campos-Nonato, IR, Cardenas, R, Carvalho, F, Chansa, C, Chattu, SK, Chattu, VK, Chu, D-T, Dai, X, Dandona, L, Dandona, R, Dangel, WJ, Daryani, A, De Neve, J-W, Dhimal, M, Dipeolu, IO, Djalalinia, S, Hoa, TD, Doshi, CP, Doshmangir, L, Ehsani-Chimeh, E, El Tantawi, M, Fernandes, E, Fischer, F, Foigt, NA, Fomenkov, AA, Foroutan, M, Fukumoto, T, Fullman, N, Gad, MM, Ghadiri, K, Ghafourifard, M, Ghashghaee, A, Glucksman, T, Goudarzi, H, Das Gupta, R, Hamadeh, RR, Hamidi, S, Haro, JM, Hasanpoor, E, Hay, S, Hegazy, M, Heibati, B, Henry, NJ, Hole, MK, Hossain, N, Househ, M, Ilesanmi, OS, Imani-Nasab, M-H, Irvani, SSN, Islam, SMS, Jahani, MA, Joshi, A, Kalhor, R, Kayode, GA, Khalid, N, Khatab, K, Kisa, A, Kochhar, S, Krishan, K, Defo, BK, Lal, DK, Lami, FH, Larsson, AO, Leasher, JL, LeGrand, KE, Lim, L-L, Mahotra, NB, Majeed, A, Maleki, A, Manjunatha, N, Massenburg, BB, Mestrovic, T, Mini, GK, Mirica, A, Mirrakhimov, EM, Mohammad, Y, Mohammed, S, Mokdad, AH, Morrison, SD, Naghavi, M, Ndwandwe, DE, Negoi, I, Negoi, RI, Ngunjiri, JW, Cuong, TN, Nigatu, YT, Onwujekwe, OE, Ortega-Altamirano, D, Otstavnov, N, Otstavnov, SS, Owolabi, MO, Pakhare, AP, Filipino Pepito, VC, Perico, N, Pham, HQ, Pigott, DM, Pokhrel, KN, Rabiee, M, Rabiee, N, Rahimi-Movaghar, V, Rawaf, DL, Rawaf, S, Rawal, L, Remuzzi, G, Renzaho, AMN, Resnikoff, S, Rezaei, N, Rezapour, A, Rickard, J, Roever, L, Sahu, M, Samy, AM, Sanabria, J, Santric-Milicevic, MM, Saraswathy, SYI, Seedat, S, Senthilkumaran, S, Servan-Mori, E, Shaikh, MA, Sheikh, A, Silva, DAS, Stein, C, Stein, DJ, Titova, MV, Topp, SM, Tovani-Palone, MR, Ullah, S, Unnikrishnan, B, Vacante, M, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Vlassov, V, Vos, T, Yearwood, JA, Yonemoto, N, Younis, MZ, Yu, C, Zadey, S, Bin Zaman, S, Zerfu, TA, Zhang, Z-J, Ziapour, A, Zodpey, S, Lim, SS, Murray, CJL, and Lozano, R

Abstract

BACKGROUND: Human resources for health (HRH) include a range of occupations that aim to promote or improve human health. The UN Sustainable Development Goals (SDGs) and the WHO Health Workforce 2030 strategy have drawn attention to the importance of HRH for achieving policy priorities such as universal health coverage (UHC). Although previous research has found substantial global disparities in HRH, the absence of comparable cross-national estimates of existing workforces has hindered efforts to quantify workforce requirements to meet health system goals. We aimed to use comparable and standardised data sources to estimate HRH densities globally, and to examine the relationship between a subset of HRH cadres and UHC effective coverage performance. METHODS: Through the International Labour Organization and Global Health Data Exchange databases, we identified 1404 country-years of data from labour force surveys and 69 country-years of census data, with detailed microdata on health-related employment. From the WHO National Health Workforce Accounts, we identified 2950 country-years of data. We mapped data from all occupational coding systems to the International Standard Classification of Occupations 1988 (ISCO-88), allowing for standardised estimation of densities for 16 categories of health workers across the full time series. Using data from 1990 to 2019 for 196 of 204 countries and territories, covering seven Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) super-regions and 21 regions, we applied spatiotemporal Gaussian process regression (ST-GPR) to model HRH densities from 1990 to 2019 for all countries and territories. We used stochastic frontier meta-regression to model the relationship between the UHC effective coverage index and densities for the four categories of health workers enumerated in SDG indicator 3.c.1 pertaining to HRH: physicians, nurses and midwives, dentistry personnel, and pharmaceutical personnel. We identified minimum workf

Published
2022

43. Resilience of people with chronic medical conditions during the COVID-19 pandemic: a 1-year longitudinal prospective survey.

Author

Tarsitani, L, Pinucci, I, Tedeschi, F, Patanè, M, Papola, D, Palantza, C, Acarturk, C, Björkenstam, E, Bryant, R, Burchert, S, Davisse-Paturet, C, Díaz-García, A, Farrel, R, Fuhr, DC, Hall, BJ, Huizink, AC, Lam, AIF, Kurt, G, Leijen, I, Mittendorfer-Rutz, E, Morina, N, Panter-Brick, C, Purba, FD, Quero, S, Seedat, S, Setyowibowo, H, van der Waerden, J, Pasquini, M, Sijbrandij, M, Barbui, C, Tarsitani, L, Pinucci, I, Tedeschi, F, Patanè, M, Papola, D, Palantza, C, Acarturk, C, Björkenstam, E, Bryant, R, Burchert, S, Davisse-Paturet, C, Díaz-García, A, Farrel, R, Fuhr, DC, Hall, BJ, Huizink, AC, Lam, AIF, Kurt, G, Leijen, I, Mittendorfer-Rutz, E, Morina, N, Panter-Brick, C, Purba, FD, Quero, S, Seedat, S, Setyowibowo, H, van der Waerden, J, Pasquini, M, Sijbrandij, M, and Barbui, C

Abstract

BACKGROUNDS: Individuals with chronic medical conditions are considered highly exposed to COVID-19 pandemic stress, but emerging evidence is demonstrating that resilience is common even among them. We aimed at identifying sustained resilient outcomes and their predictors in chronically ill people during the first year of the pandemic. METHODS: This international 4-wave 1-year longitudinal online survey included items on socio-demographic characteristics, economic and living situation, lifestyle and habits, pandemic-related issues, and history of mental disorders. Adherence to and approval of imposed restrictions, trust in governments and in scientific community during the pandemic were also investigated. The following tools were administered: the Patient Health Questionnaire, the Generalized Anxiety Disorder scale, the PTSD Checklist DSM-5, the Oslo Social Support Scale, the Padua Inventory, and the Portrait Values Questionnaire. RESULTS: One thousand fifty-two individuals reporting a chronic condition out of 8011 total participants from 13 countries were included in the study, and 965 had data available for the final model. The estimated probability of being "sustained-resilient" was 34%. Older male individuals, participants employed before and during the pandemic or with perceived social support were more likely to belong to the sustained-resilience group. Loneliness, a previous mental disorder, high hedonism, fear of COVID-19 contamination, concern for the health of loved ones, and non-approving pandemic restrictions were predictors of not-resilient outcomes in our sample. CONCLUSIONS: We found similarities and differences from established predictors of resilience and identified some new ones specific to pandemics. Further investigation is warranted and could inform the design of resilience-building interventions in people with chronic diseases.

Published
2022

44. Symptoms of anxiety and depression during the COVID-19 pandemic in six European countries and Australia - Differences by prior mental disorders and migration status.

Author

Gémes, K, Bergström, J, Papola, D, Barbui, C, Lam, AIF, Hall, BJ, Seedat, S, Morina, N, Quero, S, Campos, D, Pinucci, I, Tarsitani, L, Deguen, S, van der Waerden, J, Patanè, M, Sijbrandij, M, Acartürk, C, Burchert, S, Bryant, RA, Mittendorfer-Rutz, E, Gémes, K, Bergström, J, Papola, D, Barbui, C, Lam, AIF, Hall, BJ, Seedat, S, Morina, N, Quero, S, Campos, D, Pinucci, I, Tarsitani, L, Deguen, S, van der Waerden, J, Patanè, M, Sijbrandij, M, Acartürk, C, Burchert, S, Bryant, RA, and Mittendorfer-Rutz, E

Abstract

BACKGROUND: Little is known about changes of mental health during the COVID-19 pandemic in potentially disadvantaged groups. We investigated changes in anxiety and depression symptoms during the first year of the pandemic in six European countries and Australia by prior mental disorders and migration status. METHODS: Overall, 4674 adults answered a web-based survey in May-June 2020 and were followed by three repeated surveys up to February 2021. Information on psychosocial, financial and demographic, living conditions, prior mental disorders, depression and anxiety symptoms during the pandemic and migration status was collected. Weighted general estimation equations modelling was used to investigate the association between prior mental disorders, migration status, and symptoms over time. RESULTS: Most participants were <40 years old (48%), women (78%) and highly educated (62%). The baseline prevalence of depressive and anxiety symptoms ranged between 19%-45% and 13%-35%, respectively. In most countries, prevalence rates remained unchanged throughout the pandemic and were higher among people with prior mental disorders than without even after adjustment for several factors. We observed interactions between previous mental disorders and symptoms of anxiety or depression over time in two countries. No difference by migration status was noted. LIMITATIONS: Convenience sampling limits generalizability. Self-assessed symptoms of depression and anxiety might involve some misclassification. CONCLUSIONS: Depression and anxiety symptoms were worse among individuals with prior mental disorders than without, but there was no clear trend of worsening mental health in the observed groups during the observed period.

Published
2022

45. The Associations of Intimate Partner Violence and Non-Partner Sexual Violence with Hypertension in South African Women

Author

Nguyen, K.A., Abrahams, N., Jewkes, R., Mhlongo, S., Seedat, S., Myers-Franchi, Bronwyn, Lombard, C., Garcia-Moreno, C., Chirwa, E., Kengne, A.P., Peer, N., Nguyen, K.A., Abrahams, N., Jewkes, R., Mhlongo, S., Seedat, S., Myers-Franchi, Bronwyn, Lombard, C., Garcia-Moreno, C., Chirwa, E., Kengne, A.P., and Peer, N.

Abstract

This study describes associations of intimate partner violence (IPV), non-partner sexual violence (NPSV) and sexual harassment (SH) exposures with hypertension in South African women aged 18–40 years. Baseline data (n = 1742) from the Rape Impact Cohort Evaluation study, including a history of sexual, physical, emotional and economic IPV, NPSV and SH were examined. Hypertension was based on blood pressure ≥140/90 mmHg or a previous diagnosis. Logistic regressions were adjusted for traditional hypertension risk factors and previous trauma (e.g., recent rape). Hypertension was more prevalent in women with a history of all forms of IPV, NPSV, and SH, all p ≤ 0.001, compared to women without. Frequent NPSV (adjusted odds ratio: 1.63; 95% CI: 1.27–2.67) any SH (2.56; 1.60–4.03), frequent physical (1.44; 1.06–1.95) and emotional IPV (1.45; 1.06–1.98), and greater severity of emotional IPV (1.05; 1.02–1.08) were associated with hypertension. Current depression, post-traumatic stress symptoms and/or alcohol binge-drinking completely or partially mediated these associations. This study shows that exposure to gender-based violence is associated with hypertension in young women. Understanding the role of psychological stress arising from abuse may enable the development of prevention and management strategies for hypertension among women with histories of abuse.

Published
2022

46. Symptoms of anxiety and depression during the COVID-19 pandemic in six European countries and Australia - differences by prior mental disorders and migration status

Author

Acartürk, Zeynep Ceren (ORCID 0000-0001-7093-1554 & YÖK ID 39271), Gemes, K.; Bergstrom, J.; Papola, D.; Barbui, C.; Lam, A.I.F.; Hall, B.J.; Seedat, S.; Morina, N.; Quero, S.; Campos, D.; Pinucci, I.; Tarsitani, L.; Deguen, S.; van der Waerden, J.; Patane, M.; Sijbrandij, M.; Burchert, S.; Bryant, R.A.; Mittendorfer-Rutz, E., College of Social Sciences and Humanities, Department of Psychology, Acartürk, Zeynep Ceren (ORCID 0000-0001-7093-1554 & YÖK ID 39271), Gemes, K.; Bergstrom, J.; Papola, D.; Barbui, C.; Lam, A.I.F.; Hall, B.J.; Seedat, S.; Morina, N.; Quero, S.; Campos, D.; Pinucci, I.; Tarsitani, L.; Deguen, S.; van der Waerden, J.; Patane, M.; Sijbrandij, M.; Burchert, S.; Bryant, R.A.; Mittendorfer-Rutz, E., College of Social Sciences and Humanities, and Department of Psychology

Abstract

Background: little is known about changes of mental health during the COVID-19 pandemic in potentially disadvantaged groups. We investigated changes in anxiety and depression symptoms during the first year of the pandemic in six European countries and Australia by prior mental disorders and migration status. Methods: overall, 4674 adults answered a web-based survey in May-June 2020 and were followed by three repeated surveys up to February 2021. Information on psychosocial, financial and demographic, living conditions, prior mental disorders, depression and anxiety symptoms during the pandemic and migration status was collected. Weighted general estimation equations modelling was used to investigate the association between prior mental disorders, migration status, and symptoms over time. Results: most participants were <40 years old (48%), women (78%) and highly educated (62%). The baseline prevalence of depressive and anxiety symptoms ranged between 19%-45% and 13%-35%, respectively. In most countries, prevalence rates remained unchanged throughout the pandemic and were higher among people with prior mental disorders than without even after adjustment for several factors. We observed interactions between previous mental disorders and symptoms of anxiety or depression over time in two countries. No difference by migration status was noted. Limitations: convenience sampling limits generalizability. Self-assessed symptoms of depression and anxiety might involve some misclassification. Conclusions: depression and anxiety symptoms were worse among individuals with prior mental disorders than without, but there was no clear trend of worsening mental health in the observed groups during the observed period., European Union (EU); Horizon 2020; Research and Innovation Programme Societal Challenges

Published
2022

47. Social functioning in individuals affected by childhood maltreatment: establishing a research agenda to inform interventions

Author

Ceylan, Deniz (ORCID 0000-0002-1438-8240 & YÖK ID 137755), Pfaltz, M.C.; Halligan, S.L.; Haim-Nachum, S.; Sopp, M.R.; Ahs, F.; Bachem, R.; Bartoli, E.; Belete, H.; Belete, T.; Berzengi, A.; Dukes, D.; Essadek, A.; Iqbal, N.; Jobson, L.; Langevin, R.; Levy-Gigi, E.; Lüönd, A.M.; Martin-Soelch, C.; Michael, T.; Oe, M.; Olff, M.; Raghavan, V.; Ramakrishnan, M.; Sar V.; Spies, G.; Wadji, D.L.; Wamser-Nanney, R.; Fares-Otero, N.E.; Schnyder, U.; Seedat, S., School of Medicine, Ceylan, Deniz (ORCID 0000-0002-1438-8240 & YÖK ID 137755), Pfaltz, M.C.; Halligan, S.L.; Haim-Nachum, S.; Sopp, M.R.; Ahs, F.; Bachem, R.; Bartoli, E.; Belete, H.; Belete, T.; Berzengi, A.; Dukes, D.; Essadek, A.; Iqbal, N.; Jobson, L.; Langevin, R.; Levy-Gigi, E.; Lüönd, A.M.; Martin-Soelch, C.; Michael, T.; Oe, M.; Olff, M.; Raghavan, V.; Ramakrishnan, M.; Sar V.; Spies, G.; Wadji, D.L.; Wamser-Nanney, R.; Fares-Otero, N.E.; Schnyder, U.; Seedat, S., and School of Medicine

Abstract

Childhood maltreatment (CM) is linked to impairments in various domains of social functioning. Here, we argue that it is critical to identify factors that underlie impaired social functioning as well as processes that mediate the beneficial health effects of positive relationships in individuals exposed to CM. Key research recommendations are presented, focusing on: (1) identifying attachment-related alterations in specific inter- and intrapersonal processes (e.g., regulation of closeness and distance) that underlie problems in broader domains of social functioning (e.g., lack of perceived social support) in individuals affected by CM; (2) identifying internal (e.g., current emotional state) and external situational factors (e.g., cultural factors, presence of close others) that modulate alterations in specific social processes; and (3) identifying mechanisms that explain the positive health effects of intact social functioning. Methodological recommendations include: (1) assessing social processes through interactive and (close to) real-life assessments inside and outside the laboratory; (2) adopting an interdisciplinary, lifespan perspective to assess social processes, using multi-method assessments; (3) establishing global research collaborations to account for cultural influences on social processes and enable replications across laboratories and countries. The proposed line of research will contribute to globally develop and refine interventions that prevent CM and further positive relationships, which - likely through buffering the effects of chronic stress and corresponding allostatic load - foster resilience and improve mental and physical health, thereby reducing personal suffering and the societal and economic costs of CM and its consequences. Interventions targeting euthymia and psychological well-being are promising therapeutic concepts in this context., Swiss National Science Foundation; CIBERSAM; Biomedical Research Networking Center for Mental Health Network; German Academic Exchange Service (DAAD)

Published
2022

48. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author

Abbafati, C., Machado, D.B., Cislaghi, B., Salman, O.M., Karanikolos, M., McKee, M., Abbas, K.M., Brady, O.J., Larson, H.J., Trias-Llimós, S., Cummins, S., Langan, S.M., Sartorius, B., Hafiz, A., Jenabi, E., Mohammad Gholi Mezerji, N., Borzouei, S., Azarian, G., Khazaei, S., Abbasi, M., Asghari, B., Masoumi, S., Komaki, H., Taherkhani, A., Adabi, M., Abbasifard, M., Bazmandegan, G., Kamiab, Z., Vakilian, A., Anjomshoa, M., Mokari, A., Sabour, S., Shahbaz, M., Saeedi, R., Ahmadieh, H., Yousefinezhadi, T., Haj-Mirzaian, A., Nikbakhsh, R., Safi, S., Asgari, S., Irvani, S.N., Jahanmehr, N., Ramezanzadeh, K., Abbasi-Kangevari, M., Khayamzadeh, M., Abbastabar, H., Shirkoohi, R., Fazlzadeh, M., Janjani, H., Hosseini, M., Mansournia, M., Tohidinik, H., Bakhtiari, A., Fazaeli, A., Mousavi, S., Hasanzadeh, A., Nabavizadeh, B., Malekzadeh, R., Hashemian, M., Pourshams, A., Salimzadeh, H., Sepanlou, S.G., Afarideh, M., Esteghamati, A., Esteghamati, S., Ghajar, A., Heidari, B., Rezaei, N., Mohamadi, E., Rahimi-Movaghar, A., Rahim, F., Eskandarieh, S., Sahraian, M., Mohebi, F., Aminorroaya, A., Ebrahimi, H., Farzadfar, F., Mohajer, B., Pishgar, F., Saeedi Moghaddam, S., Shabani, M., Zarafshan, H., Abolhassani, H., Hafezi-Nejad, N., Heidari-Soureshjani, R., Abdollahi, M., Farahmand, M., Salamati, P., Mehrabi Nasab, E., Tajdini, M., Aghamir, S., Mirzaei, R., Dibaji Forooshani, Z., Khater, M.M., Abd-Allah, F., Abdelalim, A., Abualhasan, A., El-Jaafary, S.I., Hassan, A., Elsharkawy, A., Khater, A.M., Elhabashy, H.R., Salem, M.R.R., Salem, H., Sadeghi, M., Jafarinia, M., Amini-Rarani, M., Mohammadifard, N., Sarrafzadegan, N., Abdollahpour, I., Sarveazad, A., Tehrani-Banihashemi, A., Yoosefi Lebni, J., Manafi, N., Pazoki Toroudi, H., Dorostkar, F., Alipour, V., Sheikhtaheri, A., Arabloo, J., Azari, S., Ghashghaee, A., Rezapour, A., Naserbakht, M., Kabir, A., Mehri, F., Yousefifard, M., Asadi-Aliabadi, M., Babaee, E., Eshrati, B., Goharinezhad, S., Moradi-Lakeh, M., Abedi, P., Rashedi, V., Kumar, V., Elgendy, I.Y., Basu, S., Park, J., Pereira, A., Norheim, O.F., Eagan, A.W., Cahill, L.E., Sheikh, A., Abushouk, A.I., Kraemer, M.U.G., Thakur, B., Bärnighausen, T.W., Shrime, M.G., Abedi, A., Doshi, C.P., Abegaz, K.H., Geberemariyam, B.S., Aynalem, Y.A., Shiferaw, W.S., Abosetugn, A.E., Aboyans, V., Abrams, E.M., Gitimoghaddam, M., Kissoon, N., Stubbs, J.L., Brauer, M., Iyamu, I.O., Kopec, J.A., Pourmalek, F., Ribeiro, A.P., Malta, D.C., Gomez, R.S., Abreu, L.G., Abrigo, M.R.M., Almulhim, A.M., Dahlawi, S.M.A., Pottoo, F.H., Menezes, R.G., Alanzi, T.M., Alumran, A.K., Abu Haimed, A.K., Madadin, M., Alanezi, F.M., Abu-Gharbieh, E., Saddik, B., Abu-Raddad, L.J., Samy, A.M., El Nahas, N., Shalash, A.S., Nabhan, A.F., Kamath, A.M., Kassebaum, N.J., Aravkin, A.Y., Kochhar, S., Sorensen, R.J.D., Afshin, A., Burkart, K., Cromwell, E.A., Dandona, L., Dharmaratne, S.D., Gakidou, E., Hay, S.I., Kyu, H.H., Lopez, A.D., Lozano, R., Misganaw, A.T., Mokdad, A.H., Naghavi, M., Pigott, D.M., Reiner Jr, R.C., Roth, G.A., Stanaway, J.D., Vollset, S., Vos, T., Wang, H., Lim, S.S., Murray, C.J.L., Kalani, R., Ikuta, K.S., Cho, D.Y., Kneib, C.J., Crowe, C.S., Massenburg, B.B., Morrison, S.D., Acebedo, A., Adelson, J.D., Agesa, K.M., Alam, T., Albertson, S.B., Anderson, J.A., Antony, C.M., Ashbaugh, C., Assmus, M., Azhar, G., Balassyano, S., Bannick, M.S., Barthelemy, C.M., Bender, R.G., Bennitt, F.B., Bertolacci, G.J., Biehl, M.H., Bisignano, C., Boon-Dooley, A.S., Briant, P.S., Bryazka, D., Bumgarner, B.R., Callender, C.S., Cao, J., Castle, C.D., Castro, E., Causey, K., Cercy, K.M., Chalek, J., Charlson, F.J., Cohen, A.J., Comfort, H., Compton, K., Croneberger, A.J., Cruz, J.A., Cunningham, M., Dandona, R., Dangel, W.J., Dean, F.E., DeCleene, N.K., Deen, A., Degenhardt, L., Dingels, Z.V., Dippenaar, I.N., Dirac, M.A., Dolgert, A.J., Emmons-Bell, S., Estep, K., Farag, T., Feigin, V.L., Feldman, R., Ferrara, G., Ferrari, A.J., Fitzgerald, R., Force, L.M., Fox, J.T., Frank, T.D., Fu, W., Fukutaki, K., Fuller, J.E., Fullman, N., Galles, N.C., Gardner, W.M., Gershberg Hayoon, A., Goren, E., Gorman, T.M., Gottlich, H.C., Guo, G., Haddock, B., Hagins, H., Haile, L.M., Hamilton, E.B., Han, C., Han, H., Harvey, J.D., Henny, K., Henrikson, H.J., Henry, N.J., Herbert, M.E., Hsiao, T., Huynh, C.K., Iannucci, V.C., Ippolito, H., Irvine, C.M.S., Jafari, H., Jahagirdar, D., James, S.L., Johnson, C.O., Johnson, S.C., Keller, C., Kemmer, L., Kendrick, P.J., Knight, M., Kocarnik, J.M., Krohn, K.J., Larson, S.L., Lau, K.M., Ledesma, J.R., Leever, A.T., LeGrand, K.E., Lescinsky, H., Lin, C., Liu, H., Liu, Z., Lo, J., Lu, A., Ma, J., Maddison, E.R., Manguerra, H., Marks, A., Martopullo, I., Mastrogiacomo, C.I., May, E.A., Mooney, M.D., Mosser, J.F., Mullany, E.C., Mumford, J., Munro, S.B., Nandakumar, V., Nguyen, J., Nguyen, M., Nichols, E., Nixon, M.R., Odell, C.M., Ong, K.L., Orji, A.U., Ostroff, S.M., Pasovic, M., Paulson, K.R., Pease, S.A., Pennini, A., Pierce, M., Pilz, T.M., Pletcher, M., Rao, P.C., Razo, C., Redford, S.B., Reinig, N., Reitsma, M.B., Rhinehart, P., Robalik, T., Roberts, S., Roberts, N.L.S., Rolfe, S., Sbarra, A.N., Schaeffer, L.E., Shackelford, K.A., Shadid, J., Sharara, F., Shaw, D.H., Sheena, B.S., Simpson, K.E., Smith, A., Spencer, C.N., Spurlock, E.E., Stark, B.A., Steiner, C., Steuben, K.M., Sylte, D.O., Tang, M., Taylor, H.J., Terrason, S., Thomson, A.M., Torre, A.E., Travillian, R., Troeger, C.E., Vongpradith, A., Walters, M.K., Wang, J., Watson, A., Watson, S., Whisnant, J.L., Whiteford, H.A., Wiens, K.E., Wilner, L.B., Wilson, S., Wool, E.E., Wozniak, S.S., Wu, J., Wulf Hanson, S., Wunrow, H., Xu, R., Yadgir, S., Yearwood, J.A., York, H.W., Yuan, C., Zhao, J.T., Zheng, P., Zimsen, S.R.M., Zlavog, B.S., Chang, A.Y., Oren, E., Buchbinder, R., Chin, K.L., Guo, Y., Polkinghorne, K.R., Thrift, A.G., Lee, S.W.H., Ackerman, I.N., Cicuttini, F.M., Li, S., Zaman, S., Suleria, H., Zhang, J., Cowie, B.C., Wijeratne, T., Patton, G.C., Sawyer, S.M., Adair, T., Meretoja, A., Adetokunboh, O.O., Adamu, A.A., Iwu, C.J., Parry, C.D.H., Seedat, S., Ndwandwe, D.E., Mahasha, P.W., Stein, D.J., Nnaji, C.A., Sambala, E.Z., Wiysonge, C.S., Adebayo, O.M., Ilesanmi, O.S., Owolabi, M.O., Adeoye, A.M., Adedeji, I.A., Adekanmbi, V., Ibitoye, S.E., John-Akinola, Y.O., Oluwasanu, M.M., Oghenetega, O.B., Akinyemi, R.O., Zandian, H., Adham, D., Zahirian Moghadam, T., Advani, S.M., Teagle, W.L., Braithwaite, D., Agasthi, P., Saadatagah, S., Afshari, M., Agardh, E.E., Allebeck, P., Danielsson, A., Deuba, K., Carrero, J.J., Mohammad, D.K., Fereshtehnejad, S., Ärnlöv, J., Nowak, C., Cederroth, C.R., Ahmadi, A., Pathak, A., Mills, E.J., Kurmi, O.P., Olagunju, A.T., Agarwal, G., Sathish, T., Aghaali, M., Mohammadbeigi, A., Agrawal, A., Ahmad, T., Ahmadi, K., Maleki, S., Naderi, M., Salahshoor, M.R., Pourmirza Kalhori, R., Almasi, A., Salimi, Y., Siabani, S., Ziapour, A., Barzegar, A., Khazaie, H., Kianipour, N., Amiri, F., Salehi Zahabi, S., Mirzaei, M., Shamsi, M., Najafi, F., Jalali, A., Ghadiri, K., Heydarpour, F., Fattahi, N., Karami Matin, B., Kazemi Karyani, A., Pirsaheb, M., Rajati, F., Sadeghi, E., Safari, Y., Sharafi, K., Soltani, S., Vasseghian, Y., Atafar, Z., Jalilian, F., Mirzaei-Alavijeh, M., Saeidi, S., Soofi, M., Zangeneh, A., Mansouri, B., Ahmadi, M., Khafaie, M.A., Safiri, S., Moghadaszadeh, M., Asghari Jafarabadi, M., Doshmangir, L., Jadidi-Niaragh, F., Ghafourifard, M., Spotin, A., Khodayari, M., Samadi Kafil, H., Kalankesh, L.R., Ahmadpour, E., Yousefi, B., Ansari, F., Hassankhani, H., Karimi, S., Haririan, H., Mereta, S., Ahmed, M.B., Feyissa, G.T., Ciobanu, L.G., Aji, B., Aynalem, G.L., Gebresillassie, B., Tefera, Y.G., Akalu, T.Y., Baraki, A.G., Tesema, G.A., Tessema, Z.T., Tamiru, A.T., Azene, Z.N., Netsere, H.B., Yano, Y., Akinyemiju, T., Wu, C., Zadey, S., Samad, Z., Ji, J.S., Doshi, P.P., John, O., Jha, V., Maulik, P.K., Pesudovs, K., Resnikoff, S., Mitchell, P.B., Sachdev, P.S., Akombi, B., Godinho, M.A., Ivers, R.Q., Peden, A.E., Biswas, R., Boufous, S., Akunna, C.J., Alahdab, F., Hammer, M.S., van Donkelaar, A., Al-Aly, Z., Dellavalle, R.P., Alam, S., Martin, R.V., Alam, N., De Leo, D., Tadakamadla, S.K., Alam, K., Alcalde-Rabanal, J.E., Avila-Burgos, L., Serván-Mori, E., Denova-Gutiérrez, E., Rodríguez-Ramírez, S., Morales, L., Poznańska, A., Wojtyniak, B., Rivera, J.A., Campos-Nonato, I.R., Campuzano Rincon, J., Sánchez-Pimienta, T.G., Mengesha, M.B., Welay, F.T., Alema, N.M., Demsie, D.G., Teame, H., Teklehaimanot, B.F., Alemu, B.W., Gultie, T., Bante, A.B., Yeshitila, Y.G., Geramo, Y.C.D., Glagn, M., Sorrie, M.B., W/hawariat, F.G., Amare, A., Kasa, A., Alemu, Y., Mihretie, K.M., Atnafu, D.D., Demeke, F.M., Melese, A., Bante, S.A., Dessie, G.A., Mengesha, E.W., Nigatu, D., Almadi, M.A.H., Alhabib, K.F., Mohammad, Y., Altirkawi, K.A., Temsah, M., Kugbey, N., Ayanore, M.A., Alhassan, R.K., Ali, M., Ali, S., Alicandro, G., Kalhor, R., Alijanzadeh, M., Alinia, C., Yusefzadeh, H., Didarloo, A., Alizade, H., Nikpoor, A., Aljunid, S.M., Alla, F., Leal, L.F., Almasi-Hashiani, A., Moradzadeh, R., Zamanian, M., Nazari, J., Amini, S., Ghamari, F., Almasri, N.A., Khan, M., Al-Mekhlafi, H.M., Bedi, N., Alonso, J., Ciber, E.S.P., Al-Raddadi, R.M., Zakzuk, J., Alvis-Guzman, N., Alvis-Zakzuk, N.J., Castañeda-Orjuela, C.A., Malagón-Rojas, J.N., Gezae, K., Gesesew, H.A., Muthupandian, S., Gebremeskel, G.G., Berhe, K., Amare, B., Ayza, M.A., Gebremeskel, L.G., Gebreslassie, A.A.A., Bitew, H., Zewdie, K.A., Tela, F.G.G., Gill, T.K., Noubiap, J., Lassi, Z.S., Bhandari, D., Amit, A.L., Antonio, C.T., Faraon, E.A., Lopez, J.F., Atre, S.R., Ballew, S.H., Matsushita, K., Khoja, A.T., Daneshpajouhnejad, P., Ghadimi, M., Shafaat, O., Fanzo, J., Amugsi, D.A., Amul, G.H., Koh, D.S.Q., Venketasubramanian, N., Anbesu, E.W., Mohammed, J.A., Wondmeneh, T.G., Andrei, C., Negoi, R.I., Davitoiu, D.V., Manda, A., Negoi, I., Preotescu, L., Hostiuc, M., Hostiuc, S., Ancuceanu, R., Hasan, M., Leung, J., Anderlini, D., Mamun, A.A., Maravilla, J.C., McGrath, J.J., Lalloo, R., Uddin, R., Erskine, H.E., Knibbs, L.D., Mantilla Herrera, A.M., Santomauro, D.F., Mirica, A., Ausloos, M., Herteliu, C., Oţoiu, A., Pana, A., Andrei, T., Ştefan, S., Androudi, S., Angus, C., Ansari, I., Pourjafar, H., Shams-Beyranvand, M., Ansari-Moghaddam, A., Khammarnia, M., Antonazzo, I., Ferrara, P., Conti, S., Cortesi, P.A., Fornari, C., Lee, P.H., Antriyandarti, E., Yousefi, Z., Rafiei, A., Javidnia, J., Faridnia, R., Anvari, D., Goudarzian, A., Moosazadeh, M., Rezai, M., Daryani, A., Fareed, M., Anwer, R., Appiah, S., Paudel, D., Dichgans, M., Riahi, S., Rajabpour-Sanati, A., Arab-Zozani, M., Arba, A.A.K., Aremu, O., Ariani, F., Aripov, T., Armoon, B., Mahdavi, M.M., Arowosegbe, O.O., Tediosi, F., Aryal, K.K., Mosapour, A., Yaminfirooz, M., Arzani, A., Bijani, A., Jahani, M.A., Mouodi, S., Zamani, M., Asaad, M., Dianatinasab, M., Bahrami, M., Pakshir, K., Asadi-Pooya, A.A., Bayati, M., Shahabi, S., Athari, S., Atout, M.M.W., Atteraya, M.S., Brugha, T., Ausloos, F., Avokpaho, E.F.G., Room, R., Islam, M., Edvardsson, D., Rahman, M., Ayala Quintanilla, B., Gething, P.W., Briggs, A.M., Ayano, G., Hendrie, D., Miller, T.R., Azzopardi, P.S., Hoogar, P., B, D.B., Kulkarni, V., Kumar, N., Mithra, P., Shetty, R.S., Thapar, R., Padubidri, J., Bakkannavar, S.M., Nayak, V.C., Rastogi, P., Shetty, B.K., Bhageerathy, R., Gudi, N., Boloor, A., Holla, R., Rathi, P., Unnikrishnan, B., Janodia, M.D., Lang, J.J., Badawi, A., Orpana, H.M., Bhutta, Z.A., Shield, K.D., Chattu, V., Badiye, A.D., Kapoor, N., Bagherzadeh, M., Rabiee, N., Bagli, E., Baig, A.A., Bairwa, M., Lodha, R., Sagar, R., Rath, G.K., Bhardwaj, P., Charan, J., Kanchan, T., Joshi, A., Pakhare, A.P., Bakhshaei, M., Naghshtabrizi, B., Balachandran, A., Hoek, H.W., Postma, M.J., Geremew, A., Gebrehiwot, A.M., Balakrishnan, S., Desalew, A., Bojia, H.A., Mohammed, A.S., Regassa, L.D., Parmar, P.G.K., Balalla, S., Baldasseroni, A., Stokes, M.A., Ball, K., Islam, S., Maddison, R., Balzi, D., Levi, M., Banach, M., Banerjee, S.K., Banik, P.C., Barua, L., Faruque, M., Barboza, M.A., Barker-Collo, S.L., Jonas, J.B., Panda-Jonas, S., De Neve, J., Kohler, S., Moazen, B., Mohammed, S., Barrero, L.H., Basaleem, H., Bassat, Q., Haro, J.M., Koyanagi, A., Car, J., Greaves, F., Majeed, A., Davis, A.C., Steiner, T.J., Kusuma, D., Palladino, R., Rawaf, S., Saxena, S., Rawaf, D.L., Baune, B.T., Karch, A., Baye, B.A., Darega Gela, J., Kolola, T., Becker, J.S., DeLang, M., West, J., Gad, M.M., Serre, M.L., Gallus, S., Lugo, A., Beghi, E., Pupillo, E., Bosetti, C., Giussani, G., Bikbov, B., Perico, N., Remuzzi, G., Imani-Nasab, M., Nouraei Motlagh, S., Sharafi, Z., Behzadifar, M., Béjot, Y., Bekuma, T.T., Yilma, M.T., Bell, M.L., Bello, A.K., Rafiee, A., Keddie, S.H., Lucas, T.C.D., Dolecek, C., Dunachie, S.J., Rumisha, S.F., Weiss, D.J., Lewington, S., Collins, E.L., Nandi, A.K., Zhao, Y., Bennett, D.A., Karim, M.A., Lacey, B., Khundkar, R., Yaya, S., Goulart, A.C., Santos, I.S., Bensenor, I.M., Lotufo, P.A., Tovani-Palone, M.R., Castaldelli-Maia, J., Wang, Y., Furtado, J.M., Benziger, C.P., Berman, A.E., Mazidi, M., Bernabe, E., Dargan, P.I., Molokhia, M., Shibuya, K., Douiri, A., Wolfe, C.D.A., Hay, R.J., Flohr, C., Suchdev, P.S., Ram, P., Bernstein, R.S., Liu, Y., Bhagavathula, A.S., Khan, G., Grivna, M., Bhala, N., Chandan, J.S., Gaidhane, A.M., Quazi Syed, Z., Saxena, D., Khatib, M., Bhat, A.G., Bhattacharyya, K., Bhattarai, S., Das, J.K., Bibi, S., Bilano, V., Bin Sayeed, M., Cherbuin, N., D'Amico, E., Grosso, G., Borzì, A.M., Biondi, A., Vacante, M., Valli, A., Birihane, B.M., Bisanzio, D., Hassan, S., Bjørge, T., Øverland, S., Bockarie, M.J., Mensah, G.A., Sliwa, K., Gholamian, A., Bohlouli, S., Esmaeilnejad, S., Bohluli, M., Bolla, S.R., Borges, G., Bose, D., Bourne, R., Brayne, C., Breitborde, N.J.K., Fisher, J.L., Breitner, S., Brenner, H., Breusov, A.V., Rakovac, I., Briko, N.I., Lopukhov, P.D., Glushkova, E.V., Korshunov, V.A., Polibin, R.V., Jakovljevic, M., Briko, A.N., Britton, G.B., Castro, F., Moreno Velásquez, I., Burnett, R.T., Burugina Nagaraja, S., Busse, R., Butt, Z.A., Caetano dos Santos, F., Cai, T., Hall, B.J., Cahuana Hurtado, Lucero, Cámera, L.A., Valdez, P.R., Tudor Car, L., Cárdenas, R., Gorini, G., Carreras, G., Fernandes, E., Freitas, M., Pereira, D.M., Santos, J.V., Ribeiro, D., Pinheiro, M., Massano, J., das Neves, J., Dias da Silva, D., Carvalho, F., Costa, V.M., Silva, J.P., Morgado-da-Costa, J., Castelpietra, G., Catalá-López, F., Pakhale, S., Cerin, E., Yip, P., Ho, H., Chang, J., Chang, A.R., Chang, K., Cooper, O.R., Chaturvedi, S., Chimed-Ochir, O., Chirinos-Caceres, J.L., Choi, J.J., Christensen, H., Truelsen, T.C., Chu, D., Kivimäki, M., Chung, S., Kumar, M., Ward, J.L., Chung, M.T., Cirillo, M., Virclo, R., Classen, T.K.D., Lauriola, P., Corso, B., Hugo, F.N., Kieling, C., Cousin, E., Duncan, B.B., Goulart, B.N.G., Schmidt, 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Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Advani, Shailesh M, Afshin, Ashkan, Aghaali, Mohammad, Agrawal, Anurag, Ahmadi, Keivan, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Al-Aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-Rabanal, Jacqueline Elizabeth, Ali, Muhammad, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyru, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M, Altirkawi, Khalid A, Alumran, Arwa Khalid, Alvis-Guzman, Nelson, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amit, Arianna Maever L, Ancuceanu, Robert, Andrei, Catalina Liliana, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y, Aremu, 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Mekonnen, Gebremedhin, Ketema Bizuwork, Gething, Peter W, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gitimoghaddam, Mojgan, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Gopalani, Sameer Vali, Goulart, Alessandra C, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rajeev, Gupta, Subodh Sharan, Haagsma, Juanita A, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Halvaei, Iman, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Han, Chieh, Handiso, Demelash Woldeyohanne, Hankey, Graeme J, Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I, Hassanipour, Soheil, Hassankhani, Hadi, Hay, Simon I, Heibati, Behzad, Heidari-Soureshjani, Reza, Henny, Kiana, Henry, Nathaniel J, Herteliu, Claudiu, Heydarpour, Fatemeh, Hole, Michael K, Hoogar, Praveen, Hosgood, H Dean, Hossain, Naznin, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hoy, Damian G, Hu, Guoqing, Huda, Tanvir M, Ibitoye, Segun Emmanuel, Ikuta, Kevin S, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imani-Nasab, Mohammad Hasan, Islam, Mdmohaimenul, Iso, Hiroyasu, Iwu, Chinwe Juliana, Jaafari, Jalil, Jacobsen, Kathryn H, Jahagirdar, Deepa, Jahanmehr, Nader, Jalali, Amir, Jalilian, Farzad, James, Spencer L, Janjani, Hosna, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Jonas, Jost B, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Zubair, Kalani, Hamed, Kalankesh, Leila R, Kamiab, Zahra, Kanchan, Tanuj, Kapoor, Neeti, Karch, André, Karimi, Salah Eddin, Karimi, Seyed Asaad, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kayode, Gbenga A, Keiyoro, Peter Njenga, Keller, Cathleen, Khader, Yousef Saleh, Khalid, Nauman, Khan, Ejaz Ahmad, Khan, Maseer, Khang, Young-Ho, Khater, Amir M, Khater, Mona M, Khazaei, Salman, Khazaie, Habibolah, Khodayari, Mohammad Taghi, Khubchandani, Jagdish, Kianipour, Neda, Kim, Cho-il, Kim, Young-Eun, Kim, Yun Jin, Kinfu, Yohanne, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kivimäki, Mika, Komaki, Hamidreza, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael A, Krishan, Kewal, Krohn, Kris J, Kuate Defo, Barthelemy, Kumar, G Anil, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lami, Faris Hasan, Lansky, Sonia, Larson, Samantha Leigh, Larsson, Anders O, Lasrado, Savita, Lassi, Zohra S, Lazarus, Jeffrey V, Lee, Paul H, Lee, Shaun Wen Huey, Leever, Andrew T, Legrand, Kate E, Leonardi, Matilde, Li, Shanshan, Lim, Lee-Ling, Lim, Stephen S, Linn, Shai, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lopukhov, Platon D, Lotufo, Paulo A, Lozano, Rafael, Lu, Alton, Lunevicius, Raimunda, Madadin, Mohammed, Maddison, Emilie R, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Malekzadeh, Reza, Mamun, Abdullah A, Manafi, Navid, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Mastrogiacomo, Claudia I, Mathur, Manu Raj, May, Erin A, Mcalinden, Colm, Mcgrath, John J, Mckee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M, Meitei, Wahengbam Bigyananda, Memiah, Peter T N, Mendoza, Walter, Menezes, Ritesh G, Mengesha, Endalkachew Worku, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mestrovic, Tomislav, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R, Mills, Edward J, Milne, George J, Mirrakhimov, Erkin M, Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Moazen, Babak, Moghadaszadeh, Masoud, Mohamadi, Efat, Mohammad, Dara K, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadpourhodki, Reza, Mohammed, Hussen, Mohammed, Shafiu, Mohebi, Farnam, Mohseni Bandpei, Mohammad A, Mokari, Amin, Mokdad, Ali H, Momen, Natalie C, Monasta, Lorenzo, Mooney, Meghan D, Moradi, Ghobad, Moradi, Masoud, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Moreno Velásquez, Ilai, Morgado-da-Costa, Joana, Morrison, Shane Dougla, Mosser, Jonathan F, Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Musa, Kamarul Imran, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Nigatu, Yeshambel T, Nikbakhsh, Rajan, Nikpoor, Amin Reza, Nixon, Molly R, Nnaji, Chukwudi A, Nomura, Shuhei, Noubiap, Jean Jacque, Nouraei Motlagh, Soraya, Nowak, Christoph, Oţoiu, Adrian, Odell, Christopher M, Oh, In-Hwan, Oladnabi, Morteza, Olagunju, Andrew T, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omar Bali, Ahmed, Ong, Kanyin L, Onwujekwe, Obinna E, Ortiz, Alberto, Otstavnov, Nikita, Otstavnov, Stanislav S, Øverland, Simon, Owolabi, Mayowa O, P A, Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Palladino, Raffaele, Pana, Adrian, Panda-Jonas, Songhomitra, Park, Jame, Pasupula, Deepak Kumar, Patel, Jenil R, Patel, Sangram Kishor, Patton, George C, Paulson, Katherine R, Pazoki Toroudi, Hamidreza, Pease, Spencer A, Peden, Amy E, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K, Pereira, Alexandre, Pereira, David M, Perico, Norberto, Pigott, David M, Pilgrim, Thoma, Pilz, Tessa M, Piradov, Michael A, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Poznańska, Anna, Prada, Sergio I, Prakash, Sanjay, Preotescu, Liliana, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Ram, Pradhum, Ranabhat, Chhabi Lal, Rao, Sowmya J, Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawal, Lal, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M N, Resnikoff, Serge, Rezaei, Nima, Rezai, Mohammad sadegh, Rezapour, Aziz, Rickard, Jennifer, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostamian, Morteza, Rubagotti, Enrico, Rwegerera, Godfrey M, Sabour, Siamak, Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salahshoor, Mohammad Reza, Salama, Joseph S, Salamati, Payman, Salem, Marwa R Rashad, Salimi, Yahya, Salomon, Joshua A, Salz, Inbal, Samad, Zainab, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saraswathy, Sivan Yegnanarayana Iyer, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saylan, Mete, Schaeffer, Lauren E, Schiavolin, Silvia, Schwebel, David C, Schwendicke, Falk, Sekerija, Mario, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Shabani, Mahsima, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A, Shaikh, Masood Ali, Shalash, Ali S, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomar, Sharafi, Zeinab, Sharara, Fablina, Sharma, Rajesh, Shaw, David H, Sheikh, Aziz, Shin, Jae Il, Shiri, Rahman, Shrime, Mark G, Shuval, Kerem, Siabani, Soraya, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, Diego Augusto Santo, Simonetti, Biagio, Simpson, Kyle E, Singh, Jasvinder A, Skiadaresi, Eirini, Skryabin, Valentin Yurievich, Soheili, Amin, Sokhan, Anton, Sorensen, Reed J D, Soriano, Joan B, Sorrie, Muluken Bekele, Soyiri, Ireneous N, Spurlock, Emma Elizabeth, Sreeramareddy, Chandrashekhar T, Stockfelt, Leo, Stokes, Mark A, Stubbs, Jacob L, Sudaryanto, Agu, Sufiyan, Mu'awiyyah Babale, Suliankatchi Abdulkader, Rizwan, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Tadakamadla, Santosh Kumar, Taherkhani, Amir, Tang, Muming, Taveira, Nuno, Taylor, Heather Jean, Teagle, Whitney L, Tehrani-Banihashemi, Arash, Teklehaimanot, Berhane Fseha, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thomas, Nihal, Thrift, Amanda G, Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tovani-Palone, Marcos Roberto Roberto, Traini, Eugenio, Tran, Bach Xuan, Travillian, Ravensara, Trias-Llimós, Sergi, Truelsen, Thomas Clement, Tudor Car, Lorainne, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Vakilian, Alireza, Valdez, Pascual R, Valli, Alessandro, Vardavas, Constantine, Vasankari, Tommi Juhani, Vasconcelos, Ana Maria Nogale, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Vidale, Simone, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vujcic, Isidora S, Vukovic, Ana, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Walters, Magdalene K, Wang, Hongbo, Wang, Yuan-Pang, Watson, Stefanie, Wei, Jingkai, Weiss, Jordan, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wiangkham, Taweewat, Wiens, Kirsten E, Wijeratne, Tissa, Wiysonge, Charles Shey, Wojtyniak, Bogdan, Wolfe, Charles D A, Wondmieneh, Adam Belay, Wool, Eve E, Wu, Ai-Min, Wu, Junjie, Xu, Gelin, Yamada, Tomohide, Yamagishi, Kazumasa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yearwood, Jamal A, Yeheyis, Tomas Y, Yilgwan, Christopher Sabo, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yoosefi Lebni, Javad, York, Hunter W, Younis, Mustafa Z, Younker, Theodore Patrick, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zakzuk, Josefina, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zhang, Zhi-Jiang, Zheng, Peng, Zhou, Maigeng, Ziapour, Arash, Murray, Christopher J L, Collaborators, GBD 2019 Demographics, GBD 2019 Demographics Collaborator, Violante FS, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Department of Earth Systems Analysis, Biomechanical Engineering, TechMed Centre, Biomolecular Nanotechnology, Research Methodology, Measurement and Data Analysis, Materials Science and Technology of Polymers, Inorganic Materials Science, MESA+ Institute, Biomedical and Environmental Sensorsystems, Mesoscale Chemical Systems, Faculty of Engineering Technology, Nonlinear Solid Mechanics, Digital Society Institute, Pervasive Systems, Nanobiophysics, Faculty of Geo-Information Science and Earth Observation, Multi Scale Mechanics, Engineering Fluid Dynamics, Physics of Complex Fluids, Developmental BioEngineering, Physics of Fluids, Elastomer Technology and Engineering, Medical Cell Biophysics, European Membrane Institute, Department of Earth Observation Science, Biomaterials Science and Technology, Sustainable Process Technology, Department of Urban and Regional Planning and Geo-Information Management, Department of Natural Resources, XUV Optics, Databases (Former), Department of Water Resources, Psychology, Health & Technology, Membrane Science & Technology, Department of Public Health, Clinicum, HUS Neurocenter, HUS Comprehensive Cancer Center, and Environmental Sciences

Subjects
Male, very elderly, Demographic transition, HALE, 030204 cardiovascular system & hematology, preschool child, Global Burden of Disease, Carga Global de Enfermedades, 0302 clinical medicine, newborn, Risk Factors, Surveys and Questionnaires, and Risk Factors Study, 80 and over, 030212 general & internal medicine, Birth Rate, Child, Migration, 11 Medical and Health Sciences, Aged, 80 and over, education.field_of_study, Injuries, Geography, Mortality rate, 1. No poverty, DEATH, Censuses, General Medicine, SDG 10 - Reduced Inequalities, Middle Aged, Demographic analysis, 3142 Public health care science, environmental and occupational health, 3. Good health, demographic analysis, Estilo de Vida Saludable, risk factor, Child, Preschool, Demography/statistics & numerical data, Global Burden of Diseases, Injuries, Risk Factors, Fertility, Mortality, Migration, Population, epidemiology, Female, A990 Medicine and Dentistry not elsewhere classified, CHILD-MORTALITY, Live Birth, Global Health Metrics, TRANSITION, demographics, GBD, fertility, mortality, hale, Adult, Adolescent, Total fertility rate, Population, Global Burden of Diseases, Injuries, and Risk Factors Study, Birth rate, 03 medical and health sciences, Young Adult, Life Expectancy, SDG 3 - Good Health and Well-being, General & Internal Medicine, SYSTEMATIC ANALYSIS, Demografía, Humans, Global Burden of Disease Study, human, Mortality, education, Preschool, Aged, Demography, Spatial Analysis, questionnaire, Infant, Newborn, Klinisk medicin, HIV, Infant, Global Burden of Diseases, sex-specific fertility, Live Birth/epidemiology, purl.org/pe-repo/ocde/ford#3.02.00 [https], MODEL, Fertilidad, Fertility, Demographic change, Life expectancy, NA, global disease burden, Clinical Medicine, population research
Abstract

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10-14 and 50-54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings The global TFR decreased from 2.72 (95% uncertainty interval [UI] 2.66-2.79) in 2000 to 2.31 (2.17-2.46) in 2019. Global annual livebirths increased from 134.5 million (131.5-137.8) in 2000 to a peak of 139.6 million (133.0-146.9) in 2016. Global livebirths then declined to 135.3 million (127.2-144.1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2.1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27.1% (95% UI 26.4-27.8) of global livebirths. Global life expectancy at birth increased from 67.2 years (95% UI 66.8-67.6) in 2000 to 73.5 years (72.8-74.3) in 2019. The total number of deaths increased from 50.7 million (49.5-51.9) in 2000 to 56.5 million (53.7-59.2) in 2019. Under-5 deaths declined from 9.6 million (9.1-10.3) in 2000 to 5.0 million (4.3-6.0) in 2019. Global population increased by 25.7%, from 6.2 billion (6.0-6.3) in 2000 to 7.7 billion (7.5-8.0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58.6 years (56.1-60.8) in 2000 to 63.5 years (60.8-66.1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

Published
2020

49. Untargeted Metabolome Analysis of Alcohol-Exposed Pregnancies Reveals Metabolite Differences That Are Associated with Infant Birth Outcomes

Author

Mooney, S.M., Seedat, S., Hasken, J.M., Smith, S.M., May, P.A., de Vries, M.M., Parry, C.D.H., and Marais, A.-S.

Abstract

Prenatal alcohol exposure can produce offspring growth deficits and is a leading cause of neurodevelopmental disability. We used untargeted metabolomics to generate mechanistic insight into how alcohol impairs fetal development. In the Western Cape Province of South Africa, 52 women between gestational weeks 5–36 (mean 18.5 ± 6.5) were recruited, and they provided a finger-prick fasting bloodspot that underwent mass spectrometry. Metabolomic data were analyzed using partial least squares-discriminant analyses (PLS-DA) to identify metabolites that correlated with alcohol exposure and infant birth outcomes. Women who consumed alcohol in the past seven days were distinguished by a metabolite profile that included reduced sphingomyelins, cholesterol, and pregnenolones, and elevated fatty acids, acyl and amino acyl carnitines, and androsterones. Using PLS-DA, 25 of the top 30 metabolites differentiating maternal groups were reduced by alcohol with medium-chain free fatty acids and oxidized sugar derivatives having the greatest influence. A separate ortho-PLS-DA analysis identified a common set of 13 metabolites that were associated with infant length, weight, and head circumference. These included monoacylglycerols, glycerol-3-phosphate, and unidentified metabolites, and most of their associations were negative, implying they represent processes having adverse consequences for fetal development.

Published
2022
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